kainic acid has been researched along with Aging in 165 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (13.94) | 18.7374 |
| 1990's | 70 (42.42) | 18.2507 |
| 2000's | 53 (32.12) | 29.6817 |
| 2010's | 18 (10.91) | 24.3611 |
| 2020's | 1 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| Cha, M; Kim, UJ; Lee, BH; Lee, KH | 1 |
| Huang, S; Li, B; Li, Z; Liu, J; Sun, R; Yin, P; Zhu, X | 1 |
| Bouras, C; Fugistier, P; Leuba, G; Marin, P; Piotton, F; Savioz, A; Vallet, PG | 1 |
| Gulland, FM; Ramsdell, JS | 1 |
| Aoyama, Y; Itakura, C; Kim, TY; Niimi, K; Takahashi, E; Yoshimoto, T | 1 |
| Avvisati, R; Di Tommaso, M; Fezza, F; Lanuti, M; Maccarrone, M; Marinelli, S; Marrone, MC; Mercuri, NB; Rapino, C | 1 |
| Carrión, AM; Delgado-García, JM; Fontán-Lozano, A; Múnera, A; Romero-Granados, R; Troncoso, J | 1 |
| Carroll, JC; Pike, CJ; Rosario, ER | 1 |
| Hiraga, K; Ishii, Y; Kato, I; Kawaguchi, H; Mohafez, OM; Sasahara, M; Shehata, MH; Takasawa, A; Takasawa, K; Yoshida, T | 1 |
| Hata, Y; Kaneko, T; Nakamura, KC; Satoh, T; Yoshida, M | 1 |
| Chung, HY; Handa, S; Ishigami, A; Kim, K; Kim, MS; Kim, SJ; Lee, J; Maruyama, N; Park, HR; Son, TG | 1 |
| Foote, LT; Kazl, C; Kim, MJ; Koh, S | 1 |
| Hamilton, JB; Lu, CB; Powell, AD; Toescu, EC; Vreugdenhil, M | 1 |
| Anderson, NJ; Bastlund, JF; Gill, DA; Tasker, RA | 1 |
| Kardos, J; Lasztóczi, B; Nyitrai, G | 1 |
| Hattiangady, B; Rao, MS; Shetty, AK | 2 |
| Hattiangady, B; Rao, MS; Shetty, AK; Shuai, B | 1 |
| Jin, T; Mix, E; Quezada, HC; Winblad, B; Zhang, XM; Zhu, J | 1 |
| Brandt, AM; Holopainen, IE; Laurén, HB; Lopez-Picon, FR; Rios-Rojas, CJ | 1 |
| Bhattarai, JP; Han, SK; Kim, CJ; Lee, JC; Park, SA; Park, SJ; Yin, H | 1 |
| He, W; Hu, X; Wilson, CG; Wong, P; Xiong, W; Yan, R; Yang, J; Zhou, X | 1 |
| Chiba, Y; Furukawa, A; Hasegawa-Ishii, S; Hosokawa, M; Inaba, M; Kawamura, N; Shimada, A; Takei, S; Umegaki, H | 1 |
| Brown-Borg, H; Dahlheimer, K; Rakoczy, S; Sharma, S | 1 |
| Friedman, LK; Leheste, JR; Rafiuddin, A; Rudenko, V | 1 |
| Lu, CB; Toescu, EC; Vreugdenhil, M | 1 |
| Alfaro, JM; Burgos, JS; Sánchez, S; Sierra, S | 1 |
| Jinno, S; Yamada, J | 1 |
| Haugvicová, R; Kubová, H; Mares, P | 1 |
| Crawford, N; Kerr, DS; Razak, A | 1 |
| Gray, WP; May, K; Sundström, LE | 1 |
| Shetty, AK; Zaman, V | 2 |
| Dubé, C; Koning, E; Nehlig, A | 1 |
| Amato, G; Belluardo, N; Condorelli, DF; Mirone, MB; Mudò, G; Trovato-Salinaro, A | 1 |
| Hashimoto, K; Nakamura, R; Suzuki, Y; Takagi, Y; Umemura, K | 1 |
| Pérez-Cruz, C; Rocha, L | 1 |
| Li, QY; Patel, M | 1 |
| Azcoitia, I; Garcia-Segura, LM; Hales, DB; Lavaque, E; Perez-Martin, M; Sierra, A | 1 |
| Chu, Y; Csernansky, CA; Csernansky, JG; Dong, H | 1 |
| Belluardo, N; Condorelli, DF; Mirone, MB; Mudò, G; Trovato-Salinaro, A | 1 |
| Aliprandi, M; Colella, D; De Simoni, MG; Moshé, SL; Perego, C; Ravizza, T; Richichi, C; Rizzi, M; Velískŏvá, J; Vezzani, A | 1 |
| Chen, Z; Ljunggren, HG; Winblad, B; Zhu, J; Zhu, SW | 1 |
| Abrahamson, EE; Armstrong, DM; Hentosz, TM; Ikonomovic, MD; Kelly, KM; Kharlamov, EA | 1 |
| Brecht, WJ; Buttini, M; Chang, S; Dee Fish, J; Harris, FM; Huang, Y; Mahley, RW; Mucke, L; Tesseur, I; Wyss-Coray, T; Xu, Q; Yu, GQ | 1 |
| Danzer, SC; He, X; McNamara, JO | 1 |
| Abdel-Rahman, A; Rao, MS; Shetty, AK | 1 |
| Darbin, O; Naritoku, D; Patrylo, PR | 1 |
| Hattiangady, B; Rao, MS; Shetty, AK; Shetty, GA; Zaman, V | 1 |
| Toescu, EC; Vreugdenhil, M | 1 |
| Holopainen, IE; Korpi, ER; Laurén, HB; Lopez-Picon, FR | 1 |
| Friedman, LK; Kaur, J; Liu, H | 1 |
| Cole, TB; Luquet, S; Palmiter, RD; Ste Marie, L | 1 |
| Benkovic, SA; Miller, DB; O'Callaghan, JP | 1 |
| Holopainen, IE; Jalava, NS; Kukko-Lukjanov, TK; Lopez-Picon, FR | 1 |
| Avallone, JM; Friedman, LK; Magrys, B | 1 |
| Avallone, J; Friedman, LK; Gashi, E; Webster, T | 1 |
| Billard, JM; Rouaud, E | 1 |
| Beaudoin, ME; Fritz, MJ; Fulton, R; Liang, LP; Patel, M | 1 |
| Clarkson, AN; Hesp, BR; Kerr, DS; Sawant, PM | 1 |
| Chae, JS; Kim, HC; Kim, HJ; Kim, WK; Ko, KH; Shin, EJ; Wie, MB; Yen, TP | 1 |
| Duan, RS; Mohammed, AH; Winblad, B; Zhang, XM; Zhu, J; Zhu, SW | 1 |
| Ichiba, H; Saito, M; Tokuhara, D; Yamano, T; Yokoi, T | 1 |
| Bloom, CS; Chancer, ZO; Lorenzana, A; McCord, MC; Schauwecker, PE | 1 |
| Coyle, JT; Slevin, JT | 1 |
| Hambley, JW; Rogers, LJ | 1 |
| Garthwaite, J; Gilligan, GJ | 1 |
| Finch, CE | 1 |
| Krey, LC; McEwen, BS; Sapolsky, RM | 1 |
| Brookes, N; Burt, DR | 1 |
| Oja, SS; Saransaari, P | 4 |
| Horimoto, N; Kawamoto, I; Nabekura, J; Ogawa, T | 1 |
| Ferraro, TN; Golden, GT; Reyes, PF; Smith, GG | 1 |
| Cotman, CW; Kesslak, JP; Neeper, S; Yuan, D | 1 |
| Cutler, RC; Joseph, JA | 1 |
| Chang, CM; Chang, LW; Wei, JW | 1 |
| Janáky, R; Marnela, KM; Oja, SS; Saransaari, P; Varga, V | 1 |
| Cabrera, RJ; Donoso, AO; Navarro, CE | 1 |
| Navetta, MS; Ribak, CE | 1 |
| Chronopoulos, A; Gatt, A; Holmes, GL; Hyde, P; Liu, Z; Mikati, MA; Stafstrom, CE; Thurber, S; Werner, S | 1 |
| Dakshinamurti, K; Sharma, SK; Sundaram, M; Watanabe, T | 1 |
| Ghosh, A; Shatz, CJ | 1 |
| Baudry, M; Najm, I; Schreiber, SS; Thompson, RF; Tocco, G | 1 |
| Castrén, E; Cooper, J; da Penha Berzaghi, M; Lindholm, D; Sofroniew, M; Thoenen, H; Zafra, F | 1 |
| Baudry, M; Najm, I; Schreiber, SS | 1 |
| Baudry, M; Najm, I; Schreiber, SS; Tocco, G | 1 |
| Chronopoulos, A; Holmes, GL; Hyde, PA; Mikati, MA; Stafstrom, CE; Thompson, JL; Thurber, SJ | 1 |
| Benz, AM; Izumi, Y; Kurby, CO; Labruyere, J; Olney, JW; Price, MT; Zorumski, CF | 1 |
| Carmant, L; Holmes, GL; Liu, Z; Mikati, MA; Werner, SJ | 1 |
| Brann, DW; Mahesh, VB; Zamorano, PL; Zuo, Z | 1 |
| Atsuta, M; Fukumoto, S; Furukawa, K; Haraguchi, M; Shiku, H; Yamamoto, A; Yamashiro, S | 1 |
| Bizon, JL; Gallagher, M; Nicolle, MM | 1 |
| Aguilar, E; Aguilar, R; González, D; Pinilla, L; Tena-Sempere, M | 1 |
| Holmes, GL; Liu, Z | 1 |
| Gallagher, M; Gill, TM; Nicolle, MM; Shivers, A | 1 |
| Folbergrová, J; Haugvicová, R; Lisý, V; Stastný, F | 1 |
| Holmes, GL; Hori, A; Liu, Z; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y | 1 |
| Massieu, L; Tapia, R | 1 |
| Joseph, JA; Roth, GS; Zhang, L | 1 |
| Blue, ME; Brennan, EM; Johnston, MV; Martin, LJ | 1 |
| Fujii, Y; Kubo, T; Nakamura, S; Nishiike, S; Takeda, N | 1 |
| Aronica, EM; Bennett, MV; Gorter, JA; Grooms, SY; Paupard, MC; Zukin, RS | 1 |
| Akaike, N; Rhee, JS | 1 |
| Bednarski, E; Gall, CM; Lauterborn, JC; Lynch, G | 1 |
| Longone, P; Manev, H; Pesold, C; Uz, T | 1 |
| Holmes, GL; Liu, Z; Sarkisian, MR; Stafstrom, CE; Tandon, P; Yang, Y | 1 |
| Barr, GA; Goodwin, GA | 1 |
| Corriveau, RA; Huh, GS; Shatz, CJ | 1 |
| Baram, TZ; Brunson, KL; Schultz, L | 1 |
| Bolton, SJ; Perry, VH | 1 |
| Arkinstall, S; Boschert, U; Camps, M; Dickinson, R; Muda, M | 1 |
| Bardgett, ME; Csernansky, CA; Csernansky, JG; Lall, B; Montgomery, EM | 1 |
| Baldwin, RA; Katsumori, H; Wasterlain, CG | 1 |
| Aguado, F; Ferrer, I; Pozas, E | 1 |
| Akeefe, H; Bellosta, S; Buttini, M; Mahley, RW; Mucke, L; Orth, M; Pitas, RE; Wyss-Coray, T | 1 |
| Chabot, JG; Doré, S; Kar, S; Quirion, R | 1 |
| Górecki, DC; Kaczmarek, L; Lukasiuk, K; Simons, JP; Szklarczyk, A | 1 |
| Shetty, AK; Turner, DA | 2 |
| Anderson, KJ; Burchfield, DJ; Mason, KL; McGraw, TS; Sapper, MS; Theophilopoulos, DT | 1 |
| Huettner, JE; Wilding, TJ | 1 |
| Brene, S; Jubran, M; Lundströmer, K; Olson, L; Widenfalk, J | 1 |
| Henley, JM; Olivera, S; Rodriguez-Ithurralde, D | 1 |
| Buhl, EH; Hormuzdi, SG; LeBeau, FE; Monyer, H; Pais, I; Rozov, A; Towers, SK; Whittington, MA | 1 |
| Condie, BG; Fujishima, S; Hensch, TK; Mataga, N | 1 |
| Holopainen, IE; Lauren, HB; Lopez-Picon, FR; Romppanen, A | 1 |
| Haas, KZ; Moshé, SL; Opanashuk, LA; Sperber, EF; Stanton, PK | 1 |
| Bing, G; Choi, YS; Jhoo, WK; Kim, HC; Kim, WK; Ko, KH; Lee, DW; Park, ES; Ryu, JR; Shin, CY; Shin, EJ | 1 |
| Honegger, P; Richelson, E | 1 |
| Britt, MD; Gaddy, JR; Haigler, HJ; Neill, DB | 1 |
| Dawson, R; Glenton, P; Meldrum, MJ | 1 |
| Guzmán-Godínez, G; Schliebs, R | 1 |
| Lanius, RA; Shaw, C | 1 |
| Jankásková, B; Lisý, V; Stastný, F | 1 |
| Carpenter, MK; Miledi, R; Parker, I | 2 |
| Joseph, JA; Mesco, ER; Roth, GS | 1 |
| Le Gal La Salle, G; Rougon, G; Valin, A | 1 |
| Holmes, GL; Stafstrom, CE; Thompson, JL | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Gupta, M; Han, Z; Joseph, JA; Roth, GS | 1 |
| Matthews, JC; Scallet, AC | 1 |
| Barish, ME; Mansdorf, NB | 1 |
| Eybalin, M; Lenoir, M; Puel, JL; Pujol, R; Rebillard, G; Recasens, M | 1 |
| Gil-Loyzaga, P; Pujol, R | 1 |
| Ikeda, H; Kay, CD; Robbins, J | 1 |
| Benavides, J; Capdeville, C; Dauphin, F; Dubois, A; Duverger, D; Fage, D; Gotti, B; MacKenzie, ET; Scatton, B | 1 |
| Akagi, H; Miledi, R; Patton, DE | 1 |
| Erdö, SL; Wolff, JR | 1 |
| Kubová, H; Mares, P; Roztocilová, L; Velísek, L | 1 |
| Angelatoy, F; Kouvelas, ED; Voukelatou, G | 1 |
| Garthwaite, J | 1 |
| Arlis, S; Balm, M; Coyle, JT; Drucker, H; Zaczek, R | 1 |
| Garthwaite, G; Garthwaite, J | 1 |
| Garthwaite, G; Garthwaite, J; Yamini, B | 1 |
| Pettigrew, JD; Wildsoet, CF | 1 |
| Holmes, GL; Thompson, JL | 1 |
| Ehrlich, D; Morgan, IG; Tung, NN | 1 |
| Sapolsky, RM | 1 |
| Carpenter, P; Dreher, B; Lim, WL; Sefton, AJ | 1 |
| Anderson, KJ; DeKosky, ST; Scheff, SW | 1 |
| Pei, YQ; Wu, XR; Zhao, DY; Zuo, QH | 1 |
3 review(s) available for kainic acid and Aging
| Article | Year |
|---|---|
Domoic acid epileptic disease.
Topics: Aged; Aged, 80 and over; Aging; Amnesia; Animal Diseases; Animals; Behavior, Animal; Bivalvia; Epilepsy; Epilepsy, Temporal Lobe; Female; Food Contamination; Hippocampus; Humans; Kainic Acid; Male; Marine Toxins; Middle Aged; Neuromuscular Depolarizing Agents; Neurotoxins; Olfactory Pathways; Rats; Recurrence; Sea Lions; Seizures; Shellfish Poisoning | 2014 |
The relationships of aging changes in the basal ganglia to manifestations of Huntington's chorea.
Topics: Adenylyl Cyclases; Aging; Animals; Basal Ganglia; Cell Survival; Disease Models, Animal; Dopamine; Humans; Huntington Disease; Kainic Acid; Mice; Mice, Inbred CBA; Rats; Receptors, Dopamine; Species Specificity; Substantia Nigra | 1980 |
The role of oxidative stress in signal transduction changes and cell loss in senescence.
Topics: Aging; Animals; Antioxidants; Brain; Brain Diseases; Cyclic N-Oxides; Free Radicals; Humans; Hydroxyl Radical; Kainic Acid; Neurons; Nitrogen Oxides; Oxidative Stress; Signal Transduction; Spin Labels | 1994 |
162 other study(ies) available for kainic acid and Aging
| Article | Year |
|---|---|
Chronic Treatment of Ascorbic Acid Leads to Age-Dependent Neuroprotection against Oxidative Injury in Hippocampal Slice Cultures.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Neurons; Neuroprotection; Neuroprotective Agents; Organ Culture Techniques; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2021 |
Neuroprotective effects of anti-high-mobility group box 1 antibody in juvenile rat hippocampus after kainic acid-induced status epilepticus.
Topics: Aging; Animals; Antibodies; Cytokines; Disease Models, Animal; Hippocampus; HMGB1 Protein; Kainic Acid; Male; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2013 |
Comparison of frailty of primary neurons, embryonic, and aging mouse cortical layers.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons; Okadaic Acid; Peptide Fragments; Plaque, Amyloid | 2014 |
Age-dependent kainate sensitivity in heterozygous rolling Nagoya Cav2.1 channel mutant mice.
Topics: Aging; Animals; Blotting, Western; Calcium Channels, N-Type; Female; Hippocampus; In Situ Hybridization; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; p38 Mitogen-Activated Protein Kinases; Real-Time Polymerase Chain Reaction | 2014 |
Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting.
Topics: Aging; Animals; Arachidonic Acids; Endocannabinoids; Glycerides; Hippocampus; Kainic Acid; Neurons; Polyunsaturated Alkamides; Rats; Seizures | 2014 |
Histone deacetylase inhibitors improve learning consolidation in young and in KA-induced-neurodegeneration and SAMP-8-mutant mice.
Topics: Acetylation; Aging; Analysis of Variance; Animals; Association Learning; Blinking; Conditioning, Classical; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Kainic Acid; Male; Memory; Mice; Mice, Mutant Strains; Neurodegenerative Diseases; Pattern Recognition, Visual; Time Factors | 2008 |
Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats.
Topics: Aging; Animals; Cell Death; Estrogens; Female; Hippocampus; Kainic Acid; Neurons; Neuroprotective Agents; Ovariectomy; Progesterone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures | 2008 |
Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice.
Topics: Aging; Amino Acid Substitution; Animals; Brain; Cell Nucleus; Dementia; Endoplasmic Reticulum; Excitatory Amino Acid Agonists; Gene Dosage; Genetic Diseases, Inborn; Humans; Inclusion Bodies; Kainic Acid; Lysosomes; Mice; Mice, Transgenic; Mutation, Missense; Neurons; Neuropeptides; Neuroserpin; Seizures; Serpins; Spinal Cord | 2008 |
Cortical activity regulates corticothalamic synapses in dorsal lateral geniculate nucleus of rats.
Topics: Aging; Animals; Early Growth Response Protein 1; Geniculate Bodies; Immunoenzyme Techniques; Immunohistochemistry; Kainic Acid; Muscimol; Neuronal Plasticity; Neurotoxins; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Synapses; Vesicular Glutamate Transport Protein 1; Visual Cortex; Visual Pathways | 2009 |
Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis.
Topics: Aging; Animals; Calcium-Binding Proteins; Carboxylic Ester Hydrolases; Cell Line; Cerebellum; Cerebral Cortex; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Oxidative Stress; Rats; Rats, Inbred F344; Seizures; Signal Transduction; Specific Pathogen-Free Organisms | 2009 |
Early-life experience alters response of developing brain to seizures.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Brain; Convulsants; Disease Models, Animal; Encephalitis; Environmental Exposure; Epilepsy; Exploratory Behavior; Female; Gliosis; Hippocampus; Kainic Acid; Male; Maternal Deprivation; Microglia; Nerve Degeneration; Physical Stimulation; Rats; Time | 2009 |
Effect of ageing on CA3 interneuron sAHP and gamma oscillations is activity-dependent.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aging; Animals; CA3 Region, Hippocampal; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Chelating Agents; Excitatory Amino Acid Agonists; Fura-2; Interneurons; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Nimodipine; Periodicity | 2011 |
Reductions in paradoxical sleep time in adult rats treated neonatally with low dose domoic acid.
Topics: Aging; Animals; Animals, Newborn; Brain; Electrodes, Implanted; Electroencephalography; Electromyography; Kainic Acid; Male; Neurotoxins; Photoperiod; Rats; Rats, Sprague-Dawley; Sleep Stages; Sleep Wake Disorders; Sleep, REM; Telemetry; Time Factors | 2009 |
Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
Topics: Aging; Animals; Aspartic Acid; CA3 Region, Hippocampal; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epilepsy; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; Magnesium Deficiency; Male; Neurons; Neurotransmitter Transport Proteins; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Pyrrolidines; Rats; Rats, Wistar; Synaptic Transmission | 2010 |
Vulnerability of hippocampal GABA-ergic interneurons to kainate-induced excitotoxic injury during old age.
Topics: Aging; Animals; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Kainic Acid; Male; Rats; Rats, Inbred F344 | 2009 |
Deafferentation enhances neurogenesis in the young and middle aged hippocampus but not in the aged hippocampus.
Topics: Age Factors; Aging; Animals; Bromodeoxyuridine; Cell Count; Cell Differentiation; Cell Proliferation; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; Fluorescent Antibody Technique; Humans; Kainic Acid; Male; Microtubule-Associated Proteins; Models, Animal; Neural Stem Cells; Neurogenesis; Neurons; Neuropeptides; Rats; Rats, Inbred F344 | 2011 |
Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice.
Topics: Aging; Animals; Brain; Excitatory Amino Acid Agonists; Female; Flow Cytometry; Immunohistochemistry; Interleukin-10; Interleukin-18; Interleukin-6; Kainic Acid; Macrophage Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Motor Activity; Neurodegenerative Diseases; Seizures; Tumor Necrosis Factor-alpha | 2010 |
Transcriptome analysis of the hippocampal CA1 pyramidal cell region after kainic acid-induced status epilepticus in juvenile rats.
Topics: Aging; Animals; Calcium-Binding Proteins; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation, Developmental; Hippocampus; Immunohistochemistry; Kainic Acid; Long-Term Potentiation; Male; Microdissection; Neurons; Oligonucleotide Array Sequence Analysis; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Signal Transduction; Status Epilepticus; Synaptic Transmission | 2010 |
Postnatal change of GluR5 kainate receptor expression in the substantia gelatinosa neuron of the trigeminal subnucleus caudalis in mice.
Topics: Aging; Animals; Benzodiazepines; Blotting, Western; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Immunohistochemistry; Kainic Acid; Male; Mice; Neurons; Patch-Clamp Techniques; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substantia Gelatinosa; Tetrodotoxin; Trigeminal Nuclei | 2010 |
BACE1 deficiency causes altered neuronal activity and neurodegeneration.
Topics: Action Potentials; Aging; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Axons; Brain; Cell Membrane; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Phenotype; Seizures; Sodium Channels | 2010 |
Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse.
Topics: Aging; Animals; Astrocytes; Cell Size; Cytokines; Gene Expression; Hippocampus; Hyaluronan Receptors; Immunohistochemistry; Kainic Acid; Mice; Mice, Neurologic Mutants; Microglia; Neuroglia; Neurons; Neurotoxins; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Up-Regulation | 2011 |
The hippocampus of Ames dwarf mice exhibits enhanced antioxidative defenses following kainic acid-induced oxidative stress.
Topics: Aging; Animals; Excitatory Amino Acid Agonists; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hippocampus; Kainic Acid; Lipid Peroxidation; Male; Mice; Mice, Mutant Strains; Models, Animal; NF-E2-Related Factor 2; Oxidative Stress | 2010 |
Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Benzoxazines; Cannabinoids; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Kainic Acid; Male; Morpholines; Naphthalenes; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Seizures; Severity of Illness Index; Status Epilepticus | 2012 |
The effect of aging-associated impaired mitochondrial status on kainate-evoked hippocampal gamma oscillations.
Topics: Aging; Animals; Calcium; Electrophysiological Phenomena; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mitochondria; Neurons | 2012 |
Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish.
Topics: Aging; Animals; Docosahexaenoic Acids; Embryo, Nonmammalian; Female; Kainic Acid; Male; Seizures; Zebrafish | 2012 |
Upregulation of calcium binding protein, S100A6, in activated astrocytes is linked to glutamate toxicity.
Topics: Aging; Animals; Astrocytes; Axotomy; CA3 Region, Hippocampal; Cell Count; Cell Cycle Proteins; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Glutamic Acid; Hippocampus; Hypoglossal Nerve; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Rats; Rats, Wistar; S100 Calcium Binding Protein A6; S100 Proteins; Tissue Fixation; Up-Regulation | 2012 |
Interaction of excitatory amino acid agonists with cortical afterdischarges in developing rats.
Topics: Aging; Animals; Cerebral Cortex; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Homocysteine; Kainic Acid; N-Methylaspartate; Rats; Rats, Wistar | 2002 |
Age-related changes in tolerance to the marine algal excitotoxin domoic acid.
Topics: Aging; Animals; Calcium Channel Blockers; Drug Tolerance; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Neuromuscular Depolarizing Agents; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 2002 |
Seizure induced dentate neurogenesis does not diminish with age in rats.
Topics: Aging; Animals; Bromodeoxyuridine; Cell Count; Dentate Gyrus; Excitatory Amino Acid Agonists; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Seizures | 2002 |
Survival of fetal hippocampal CA3 cell grafts in the middle-aged and aged hippocampus: effect of host age and deafferentation.
Topics: Age Factors; Aging; Animals; Brain Tissue Transplantation; Bromodeoxyuridine; Cell Count; Cell Survival; Fetal Tissue Transplantation; Graft Survival; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Rats; Rats, Inbred F344 | 2002 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures.
Topics: Aging; Animals; Animals, Newborn; Cerebellar Cortex; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Kainic Acid; Lithium; Male; Muscarinic Agonists; Pentylenetetrazole; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Reaction Time; Status Epilepticus | 2002 |
Connexin-30 mRNA is up-regulated in astrocytes and expressed in apoptotic neuronal cells of rat brain following kainate-induced seizures.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Astrocytes; Brain; Cell Communication; Connexins; Excitatory Amino Acid Agonists; Gene Expression; Immunohistochemistry; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; RNA, Messenger; Seizures; Status Epilepticus; Up-Regulation | 2002 |
Ability of NMDA and non-NMDA receptor antagonists to inhibit cerebral ischemic damage in aged rats.
Topics: Aging; Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Telencephalon | 2003 |
Kainic acid modifies mu-receptor binding in young, adult, and elderly rat brain.
Topics: Aging; Animals; Animals, Newborn; Binding Sites; Brain; Convulsants; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Epilepsy; Kainic Acid; Male; Neurons; Opioid Peptides; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, mu; Status Epilepticus; Up-Regulation | 2002 |
Age dependence of seizure-induced oxidative stress.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aconitate Hydratase; Aging; Animals; Cerebral Cortex; Deoxyguanosine; DNA Damage; Excitatory Amino Acid Agonists; Fumarate Hydratase; Hippocampus; Immunoblotting; Kainic Acid; Mitochondria; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures; Superoxide Dismutase; Superoxides | 2003 |
Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury.
Topics: Aging; Animals; Animals, Newborn; Brain Chemistry; Brain Injuries; Bromodeoxyuridine; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Immunohistochemistry; Kainic Acid; Male; Neurons; Phosphoproteins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2003 |
Intracerebroventricular kainic acid administration to neonatal rats alters interneuron development in the hippocampus.
Topics: Aging; Animals; Animals, Newborn; Calbindin 1; Calbindins; Cell Count; Excitatory Amino Acid Agonists; Female; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Interneurons; Isoenzymes; Kainic Acid; Male; Parvalbumins; Rats; S100 Calcium Binding Protein G; Staining and Labeling | 2003 |
Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Autoradiography; Brain; Connexins; Densitometry; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation, Developmental; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Kainic Acid; Male; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Time Factors; Tubulin | 2003 |
Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development.
Topics: Aging; Animals; Animals, Newborn; Cytokines; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Gliosis; Hippocampus; Inflammation Mediators; Interleukin 1 Receptor Antagonist Protein; Kainic Acid; Male; Nerve Degeneration; Neuroglia; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Status Epilepticus; Up-Regulation | 2003 |
Reduced susceptibility to kainic acid-induced excitoxicity in T-cell deficient CD4/CD8(-/-) and middle-aged C57BL/6 mice.
Topics: Aging; Animals; CD4 Antigens; CD4-Positive T-Lymphocytes; CD8 Antigens; CD8-Positive T-Lymphocytes; Kainic Acid; Lymphopenia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity | 2004 |
Alterations in hippocampal voltage-gated calcium channel alpha 1 subunit expression patterns after kainate-induced status epilepticus in aging rats.
Topics: Aging; Animals; Calcium Channels; Calcium Channels, R-Type; Cation Transport Proteins; Gene Expression Regulation; Hippocampus; Ion Channel Gating; Kainic Acid; Male; Nerve Tissue Proteins; Protein Subunits; Rats; Rats, Inbred F344; Status Epilepticus | 2003 |
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.
Topics: Aging; Alzheimer Disease; Animals; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Astrocytes; Brain; Brain Chemistry; Female; Gene Targeting; Glial Fibrillary Acidic Protein; Humans; Kainic Acid; Mice; Mice, Transgenic; Neurons; Neurotoxins; Peptide Fragments; Phosphopyruvate Hydratase; Phosphorylation; Promoter Regions, Genetic; tau Proteins | 2004 |
Ontogeny of seizure-induced increases in BDNF immunoreactivity and TrkB receptor activation in rat hippocampus.
Topics: Aging; Animals; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Disease Models, Animal; Epilepsy; Hippocampus; Immunohistochemistry; Kainic Acid; Mossy Fibers, Hippocampal; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkB; Status Epilepticus; Up-Regulation | 2004 |
Nestin expression in hippocampal astrocytes after injury depends on the age of the hippocampus.
Topics: Aging; Animals; Astrocytes; Denervation; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; Intermediate Filament Proteins; Kainic Acid; Male; Nerve Degeneration; Nerve Tissue Proteins; Nestin; Rats; Rats, Inbred F344; S100 Proteins | 2004 |
Aging alters electroencephalographic and clinical manifestations of kainate-induced status epilepticus.
Topics: Age Factors; Aging; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Kainic Acid; Male; Motor Activity; Rats; Rats, Inbred F344; Reaction Time; Status Epilepticus | 2004 |
Hippocampal neurotrophin levels after injury: Relationship to the age of the hippocampus at the time of injury.
Topics: Aging; Animals; Behavior, Animal; Brain Chemistry; Brain Injuries; CD11b Antigen; Cell Count; Enzyme-Linked Immunosorbent Assay; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Nerve Growth Factors; Rats; Rats, Inbred F344 | 2004 |
Age-dependent reduction of gamma oscillations in the mouse hippocampus in vitro.
Topics: Age Factors; Aging; Animals; Carbachol; Cholinergic Agonists; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Hippocampus; Kainic Acid; Male; Mice; Organ Culture Techniques | 2005 |
Kainic acid-induced status epilepticus alters GABA receptor subunit mRNA and protein expression in the developing rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Fluoresceins; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Organic Chemicals; Phenothiazines; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Staining and Labeling; Status Epilepticus | 2005 |
Perinatal seizures preferentially protect CA1 neurons from seizure-induced damage in prepubescent rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Agonists; Female; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Status Epilepticus | 2006 |
Modulation of neuropeptide Y expression in adult mice does not affect feeding.
Topics: Aging; Alleles; Animals; Appetite; Body Weight; Brain; Feeding Behavior; Gene Expression Regulation; Half-Life; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuropeptide Y; RNA, Messenger; Seizures | 2005 |
Regional neuropathology following kainic acid intoxication in adult and aged C57BL/6J mice.
Topics: Aging; Animals; Brain; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hippocampus; Histocytochemistry; Immunoglobulin G; Immunohistochemistry; Kainic Acid; Lectins; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Seizures; Staining and Labeling | 2006 |
Changes in microtubule-associated protein-2 (MAP2) expression during development and after status epilepticus in the immature rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Axons; Convulsants; Dentate Gyrus; Hippocampus; Immunohistochemistry; Kainic Acid; Microtubule-Associated Proteins; Molecular Weight; Protein Isoforms; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2007 |
Maturational effects of single and multiple early-life seizures on AMPA receptors in prepubescent hippocampus.
Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sexual Maturation; Staining and Labeling; Status Epilepticus | 2007 |
Altered excitability and distribution of NMDA receptor subunit proteins in cortical layers of rat pups following multiple perinatal seizures.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Cerebral Cortex; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Up-Regulation | 2007 |
Deficit of NMDA receptor activation in CA1 hippocampal area of aged rats is rescued by D-cycloserine.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloserine; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Long-Term Potentiation; Male; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2007 |
Kainate-induced seizures, oxidative stress and neuronal loss in aging rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Behavior, Animal; Cell Death; Deoxyguanosine; Dose-Response Relationship, Drug; Kainic Acid; Male; Neurons; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Time Factors | 2007 |
Domoic acid preconditioning and seizure induction in young and aged rats.
Topics: Aging; Animals; Kainic Acid; Male; Motor Activity; Neurotoxins; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats.
Topics: Aging; Animals; Antioxidants; Drug Resistance; Enzyme Activation; Epilepsy; Excitatory Amino Acid Agonists; Genetic Predisposition to Disease; Glutathione; Glutathione Peroxidase; Hippocampus; Kainic Acid; Lipid Peroxidation; Male; Nerve Degeneration; Neuroglia; Neurotoxins; Oxidative Stress; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxide Dismutase-1 | 2008 |
Plasticity of hippocampal stem/progenitor cells to enhance neurogenesis in response to kainate-induced injury is lost by middle age.
Topics: Adult Stem Cells; Aging; Animals; Bromodeoxyuridine; Cell Count; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Survival; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; Kainic Acid; Microtubule-Associated Proteins; Neurons; Neuropeptides; Rats; Rats, Inbred F344; Stem Cells | 2008 |
Gender differences in susceptibility to kainic acid-induced neurodegeneration in aged C57BL/6 mice.
Topics: Aging; Animals; Astrocytes; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Degeneration; Nerve Growth Factors; Seizures; Sex Characteristics | 2008 |
Hippocampal BDNF and TrkB expression in young rats after status epilepticus.
Topics: Aging; Animals; Brain-Derived Neurotrophic Factor; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Receptor, trkB; Status Epilepticus | 2007 |
Effect of age on kainate-induced seizure severity and cell death.
Topics: Aging; Animals; Cell Count; Cell Death; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Seizures; Species Specificity | 2008 |
Ontogeny of receptor binding sites for [3H]glutamic acid and [3H]kainic acid in the rat cerebellum.
Topics: Aging; Animals; Animals, Newborn; Cerebellum; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Pyrrolidines; Rats; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Kainic Acid | 1981 |
Specific and non-specific effects of neuro-excitatory amino acids on learning and other behaviours in the chicken.
Topics: Aggression; Aging; Animals; Aspartic Acid; Behavior, Animal; Chickens; Copulation; Glutamates; Glutamic Acid; Habituation, Psychophysiologic; Humans; Kainic Acid; Learning; N-Methylaspartate; Pattern Recognition, Visual; Pyrrolidines; Visual Perception | 1982 |
Kainate-glutamate interactions in rat cerebellar slices.
Topics: Aging; Animals; Cell Survival; Cerebellum; Cyclic GMP; Drug Interactions; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Pyrrolidines; Rats; Rats, Inbred Strains | 1984 |
Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.
Topics: Adrenal Cortex; Adrenalectomy; Aging; Animals; Cold Temperature; Corticosterone; Hippocampus; Humans; Kainic Acid; Male; Neurons; Rats; Rats, Brattleboro; Rats, Inbred F344; Receptors, Glucocorticoid; Receptors, Steroid; Restraint, Physical; Stress, Physiological; Stress, Psychological; Vibration | 1984 |
Development of muscarinic receptor binding in spinal cord cell cultures and its reduction by glutamic and kainic acids.
Topics: Aging; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glutamates; Kainic Acid; Mice; Mice, Inbred Strains; Pyrrolidines; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Cholinergic; Receptors, Muscarinic; Spinal Cord | 1980 |
Glycine release from hippocampal slices in developing and ageing mice: modulation by glutamatergic receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Dizocilpine Maleate; Female; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Potassium; Quisqualic Acid; Receptors, Glutamate; Tetrazoles | 1994 |
Developmental change of the potentiation of NMDA response by spermine.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Synergism; Electrophysiology; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Nystatin; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spermine; Ventromedial Hypothalamic Nucleus | 1995 |
Rat strain and age differences in kainic acid induced seizures.
Topics: Aging; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Kainic Acid; Male; Rats; Rats, Inbred F344; Rats, Inbred WF; Rats, Sprague-Dawley; Seizures; Species Specificity; Status Epilepticus | 1995 |
Vulnerability of the hippocampus to kainate excitotoxicity in the aged, mature and young adult rat.
Topics: Aging; Animals; Hippocampus; Kainic Acid; Male; Neurotoxins; Rats; Rats, Sprague-Dawley | 1995 |
Differential responses in cyclic GMP formation induced by excitatory amino acids (EAA) and sodium nitroprusside (SNP) in various regions of the brain and of rats of varied age.
Topics: Aging; Amino Acids; Animals; Brain; Cyclic GMP; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Nitroprusside; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 1993 |
Interactions of gamma-L-glutamyltaurine with excitatory aminoacidergic neurotransmission.
Topics: Aging; Animals; Aspartic Acid; Brain; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Cyclic GMP; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kainic Acid; Mice; Neurons; Potassium; Rats; Rats, Wistar; Receptors, Glutamate; Stereoisomerism; Synaptic Transmission; Synaptosomes; Taurine | 1994 |
Release of 3H-noradrenaline by excitatory amino acids from rat mediobasal hypothalamus and the influence of aging.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acids; Animals; Glutamates; Glutamic Acid; Hypothalamus, Middle; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Rats; Tritium | 1994 |
Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Quisqualic Acid; Receptors, GABA; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Taurine | 1994 |
An immature mossy fiber innervation of hilar neurons may explain their resistance to kainate-induced cell death in 15-day-old rats.
Topics: Aging; Animals; Axons; Carbocyanines; Cell Death; Hippocampus; Kainic Acid; Microscopy, Electron; Nerve Fibers; Neurons; Rats; Rats, Sprague-Dawley; Synapses | 1994 |
Phenobarbital modifies seizure-related brain injury in the developing brain.
Topics: Aging; Analysis of Variance; Animals; Brain Diseases; Kainic Acid; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus | 1994 |
Hippocampal changes in developing postnatal mice following intrauterine exposure to domoic acid.
Topics: Aging; Analysis of Variance; Animals; Brain; Calcium; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Kinetics; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Neurons; Neurotoxins; Pregnancy; Pyramidal Tracts; Receptors, Kainic Acid; Seizures | 1993 |
Segregation of geniculocortical afferents during the critical period: a role for subplate neurons.
Topics: Aging; Animals; Animals, Newborn; Axons; Cats; Cerebral Cortex; Functional Laterality; Geniculate Bodies; Kainic Acid; Neurons; Neurons, Afferent; Ocular Physiological Phenomena; Time Factors; Visual Cortex | 1994 |
Cycloheximide prevents kainate-induced neuronal death and c-fos expression in adult rat brain.
Topics: Aging; Animals; Autoradiography; Brain; Cell Death; Cycloheximide; Gene Expression; Genes, fos; In Situ Hybridization; Kainic Acid; Male; Neurons; Organ Specificity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sulfur Radioisotopes | 1993 |
Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cerebral Ventricles; Dizocilpine Maleate; Gene Expression; Hippocampus; In Situ Hybridization; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Neurotrophin 3; Pilocarpine; Pyramidal Tracts; Rats; Rats, Wistar; RNA Probes; RNA, Messenger; Scopolamine; Transcription, Genetic | 1993 |
Transcriptional activation of ornithine decarboxylase in adult and neonatal hippocampal slices.
Topics: Aging; Animals; Animals, Newborn; Asparagine; Blotting, Northern; Dactinomycin; Enzyme Activation; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Ornithine Decarboxylase; Polyamines; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Transcription, Genetic | 1993 |
Seizure activity causes a rapid increase in sulfated glycoprotein-2 messenger RNA in the adult but not the neonatal rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Clusterin; Glycoproteins; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Molecular Chaperones; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1993 |
Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility.
Topics: Administration, Inhalation; Aging; Animals; Animals, Newborn; Behavior, Animal; Disease Susceptibility; Electric Stimulation; Flurothyl; Handling, Psychological; Kainic Acid; Kindling, Neurologic; Learning; Male; Memory; Rats; Rats, Sprague-Dawley; Seizures | 1993 |
An ex vivo rat retinal preparation for excitotoxicity studies.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chick Embryo; Excitatory Amino Acid Agonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Rats; Rats, Sprague-Dawley; Retina | 1995 |
Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals.
Topics: Aging; Animals; Brain Diseases; Excitatory Amino Acids; Inositol Phosphates; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 1995 |
Decreased gonadotropin-releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging?
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arcuate Nucleus of Hypothalamus; Base Sequence; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Gonadotropin-Releasing Hormone; Kainic Acid; Luteinizing Hormone; Median Eminence; Molecular Sequence Data; N-Methylaspartate; Preoptic Area; Proestrus; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1996 |
Site restricted and neuron dominant expression of alpha 2,8sialyltransferase gene in the adult mouse brain and retina.
Topics: Aging; Animals; Astrocytes; Base Sequence; Blotting, Southern; Brain; Colchicine; DNA Primers; Embryonic and Fetal Development; Female; Gangliosides; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; In Situ Hybridization; Kainic Acid; Male; Mesencephalon; Mice; Mice, Inbred BALB C; Neurons; Organ Specificity; Polymerase Chain Reaction; Retina; RNA, Messenger; Sialyltransferases | 1996 |
In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: relationship to spatial learning.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; Kainic Acid; Male; Maze Learning; N-Methylaspartate; Organ Specificity; Prosencephalon; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Tritium | 1996 |
Effects of N-methyl-D-aspartate and kainic acid on prolactin secretion in prepubertal female rats.
Topics: Aging; Animals; Dopamine; Enzyme Inhibitors; Female; Kainic Acid; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Pituitary Gland; Prolactin; Rats; Rats, Wistar; Serotonin; Sexual Maturation | 1996 |
Basic fibroblast growth factor is highly neuroprotective against seizure-induced long-term behavioural deficits.
Topics: Aging; Animals; Behavior, Animal; Cognition Disorders; Excitatory Amino Acid Agonists; Fibroblast Growth Factor 2; Flurothyl; Handling, Psychological; Kainic Acid; Learning Disabilities; Male; Maze Learning; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus | 1997 |
Hippocampal N-methyl-D-aspartate and kainate binding in response to entorhinal cortex aspiration or 192 IgG-saporin lesions of the basal forebrain.
Topics: Acetylcholinesterase; Aging; Animals; Antibodies, Monoclonal; Cholinergic Agents; Entorhinal Cortex; Glutamic Acid; Hippocampus; Immunotoxins; Kainic Acid; Kinetics; Male; N-Glycosyl Hydrolases; N-Methylaspartate; Neurons; Prosencephalon; Pyramidal Tracts; Radioligand Assay; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Ribosome Inactivating Proteins, Type 1; Saporins; Tritium | 1997 |
Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Binding Sites; Cerebral Cortex; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Wistar; Reference Values; Seizures; Synaptic Membranes; Tritium | 1997 |
Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study.
Topics: Aging; Animals; Brain Chemistry; Electroencephalography; Excitatory Amino Acid Agonists; Extracellular Space; Glutamic Acid; Kainic Acid; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Glutamate uptake impairment and neuronal damage in young and aged rats in vivo.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dicarboxylic Acids; Glutamic Acid; Hippocampus; Kainic Acid; Kinetics; Male; Microdialysis; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar | 1997 |
Effect of aging on vulnerability of striatal D1 and D2 dopamine receptor-containing neurons to kainic acid.
Topics: Aging; Animals; Corpus Striatum; Excitatory Amino Acid Agonists; Kainic Acid; Neurons; Neurotoxins; Protein Binding; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1997 |
Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: II. Alpha-AMPA and kainate receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Autoradiography; Gene Expression Regulation, Developmental; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Immunohistochemistry; Kainic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Tritium; Vibrissae | 1997 |
Sensory response of the locus ceruleus: neonatal and adult studies.
Topics: Aging; Animals; Animals, Newborn; Electric Stimulation; Epinephrine; Fetus; Frontal Lobe; Functional Laterality; Kainic Acid; Locus Coeruleus; Neurons; Neurons, Afferent; Physical Stimulation; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Tympanic Membrane; Vestibule, Labyrinth | 1998 |
Status epilepticus-induced alterations in metabotropic glutamate receptor expression in young and adult rats.
Topics: Aging; Animals; Animals, Suckling; Cell Death; Dentate Gyrus; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; Glutamic Acid; In Situ Hybridization, Fluorescence; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Degeneration; Nerve Tissue Proteins; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger; Status Epilepticus | 1997 |
Age-related functional changes of the glutamate receptor channels in rat Meynert neurones.
Topics: Acetylcholinesterase; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Electric Stimulation; Electrophysiology; Histocytochemistry; In Vitro Techniques; Ion Channels; Kainic Acid; Membrane Potentials; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Substantia Innominata | 1997 |
Kainate potentiates D-aspartate release from hippocampal slices from developing and ageing mice.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Excitatory Amino Acid Agonists; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Stimulation, Chemical | 1997 |
Taurine release from the developing and ageing hippocampus: stimulation by agonists of ionotropic glutamate receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, Glutamate; Taurine | 1997 |
Lysosomal dysfunction reduces brain-derived neurotrophic factor expression.
Topics: Aging; Animals; Brain-Derived Neurotrophic Factor; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Densitometry; Dentate Gyrus; Diazomethane; Endopeptidases; Gene Expression Regulation; Hippocampus; Kainic Acid; Lysosomes; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability.
Topics: Aging; Animals; Arachidonate 5-Lipoxygenase; Caffeic Acids; DNA; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Hippocampus; Kainic Acid; Lipoxygenase Inhibitors; Male; Neurons; Rats; Rats, Inbred F344; RNA, Messenger; Up-Regulation | 1998 |
Synaptic reorganization following kainic acid-induced seizures during development.
Topics: Aging; Animals; Dentate Gyrus; Excitatory Amino Acid Agonists; GAP-43 Protein; Immunohistochemistry; Kainic Acid; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Synapses | 1998 |
Behavioral and heart rate effects of infusing kainic acid into the dorsal midbrain during early development in the rat.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Body Temperature; Escape Reaction; Heart Rate; Injections; Kainic Acid; Mesencephalon; Rats; Rats, Inbred Strains | 1998 |
Regulation of class I MHC gene expression in the developing and mature CNS by neural activity.
Topics: Aging; Animals; Brain; Cats; Cell Communication; Embryonic and Fetal Development; Fetus; Gene Expression Regulation; Gene Expression Regulation, Developmental; Genes, MHC Class I; Histocompatibility Antigens Class I; Kainic Acid; Neurons; Organ Specificity; Polymerase Chain Reaction; Rats; RNA, Messenger; Seizures; Synapses; Tetrodotoxin; Transcription, Genetic | 1998 |
The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation.
Topics: Aging; Animals; Animals, Newborn; Corticotropin-Releasing Hormone; Differential Threshold; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hormone Antagonists; Kainic Acid; Kindling, Neurologic; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures | 1998 |
Differential blood-brain barrier breakdown and leucocyte recruitment following excitotoxic lesions in juvenile and adult rats.
Topics: Aging; Animals; Astrocytes; Biomarkers; Blood-Brain Barrier; Brain; Excitatory Amino Acid Agonists; Immunoenzyme Techniques; Inflammation; Kainic Acid; Leukocytes; Male; Microglia; N-Methylaspartate; Nerve Degeneration; Permeability; Rats; Rats, Wistar; Time Factors | 1998 |
Regulated expression of dual specificity protein phosphatases in rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Cell Cycle Proteins; Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 6; Dual-Specificity Phosphatases; Immediate-Early Proteins; In Situ Hybridization; Kainic Acid; Male; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Rats; Rats, Wistar; RNA, Messenger; Seizures; Time Factors; Tissue Distribution | 1998 |
Delayed neuronal loss after administration of intracerebroventricular kainic acid to preweanling rats.
Topics: Aging; Animals; Animals, Suckling; Cell Count; Female; Glial Fibrillary Acidic Protein; Hippocampus; HSP70 Heat-Shock Proteins; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; Neurons; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Reverse transport of glutamate during depolarization in immature hippocampal slices.
Topics: Aging; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; Calcium; Dicarboxylic Acids; Extracellular Space; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Neurotransmitter Uptake Inhibitors; Potassium; Pyrrolidines; Rats; Rats, Wistar; Sodium | 1999 |
Fra-1 immunoreactivity in the rat brain during normal postnatal development and after injury in adulthood.
Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Brain; Brain Injuries; Gene Expression Regulation; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Immunohistochemistry; Kainic Acid; Neurons; Organ Specificity; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1999 |
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.
Topics: Aging; Alzheimer Disease; Animals; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Brain Chemistry; Dendrites; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Genotype; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurotoxins; Presynaptic Terminals; RNA, Messenger; Synaptophysin | 1999 |
Impact of neonatal kainate treatment on hippocampal insulin-like growth factor receptors.
Topics: Aging; Animals; Animals, Newborn; Binding Sites; Hippocampus; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Kainic Acid; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Receptors, Somatomedin | 1999 |
Differential seizure-induced and developmental changes of neurexin expression.
Topics: Aging; Animals; Animals, Newborn; Gene Expression; Isomerism; Kainic Acid; Male; Nerve Tissue Proteins; Pentylenetetrazole; Rats; Rats, Wistar; RNA Splicing; Seizures | 1999 |
Vulnerability of the dentate gyrus to aging and intracerebroventricular administration of kainic acid.
Topics: Aging; Animals; Cerebral Ventricles; Dentate Gyrus; Injections, Intraventricular; Kainic Acid; Male; Neurons; Rats; Rats, Inbred F344 | 1999 |
Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation.
Topics: Aging; Animals; Axons; Cell Size; Denervation; Excitatory Amino Acid Agonists; Injections, Intraventricular; Kainic Acid; Male; Mossy Fibers, Hippocampal; Pyramidal Cells; Rats; Rats, Inbred F344 | 1999 |
The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Embryonic and Fetal Development; Fetus; Glutamic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Sheep | 1999 |
Functional diversity and developmental changes in rat neuronal kainate receptors.
Topics: Aging; Animals; Animals, Newborn; Cells, Cultured; Electric Conductivity; Embryo, Mammalian; Excitatory Amino Acid Agonists; Ganglia, Spinal; Hippocampus; Isoxazoles; Kainic Acid; Neurons; Propionates; Rats; Rats, Long-Evans; Receptors, Kainic Acid; Spinal Cord | 2001 |
Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Axotomy; Disease Models, Animal; Female; Gene Expression Regulation; Kainic Acid; Meninges; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; Receptors, Nerve Growth Factor; RNA, Messenger; Schwann Cells; Spinal Cord; Spinal Cord Injuries; Wounds, Nonpenetrating | 2001 |
Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain.
Topics: Acetylcholinesterase; Aging; Alanine; Animals; Autoradiography; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Binding, Competitive; Brain; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Pyrimidines; Rats; Rats, Wistar; Receptors, AMPA; Solubility; Tritium | 2001 |
Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice.
Topics: Aging; Animals; Brain; Carbachol; Cerebral Cortex; Connexins; Electroencephalography; Gap Junction delta-2 Protein; Gap Junctions; Gene Expression Regulation, Developmental; Hippocampus; In Vitro Techniques; Kainic Acid; Mice; Mice, Knockout; Nerve Net; Neurons; Oscillometry; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription, Genetic | 2001 |
Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268.
Topics: Aging; Animals; Biomarkers; Dark Adaptation; DNA-Binding Proteins; Dominance, Ocular; Early Growth Response Protein 1; Early Growth Response Protein 2; Early Growth Response Protein 3; Gene Targeting; Immediate-Early Proteins; Kainic Acid; Mice; Mice, Knockout; Neuronal Plasticity; Neurons; Photic Stimulation; Proto-Oncogene Proteins c-fos; RNA, Messenger; Sensory Deprivation; Transcription Factors; Visual Cortex; Visual Perception | 2001 |
Fetal hippocampal CA3 cell grafts transplanted to lesioned CA3 region of the adult hippocampus exhibit long-term survival in a rat model of temporal lobe epilepsy.
Topics: Aging; Animals; Biomarkers; Brain Tissue Transplantation; Bromodeoxyuridine; Cell Count; Epilepsy, Temporal Lobe; Fetal Tissue Transplantation; Graft Survival; Hippocampus; Immunohistochemistry; Kainic Acid; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Pyramidal Cells; Rats; Rats, Inbred F344 | 2001 |
Changes in neurofilament protein-immunoreactivity after kainic acid treatment of organotypic hippocampal slice cultures.
Topics: Aging; Animals; Animals, Newborn; Cell Death; Down-Regulation; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunoblotting; Immunohistochemistry; Kainic Acid; Neurofilament Proteins; Neuronal Plasticity; Neurotoxins; Organ Culture Techniques; Pyramidal Cells; Rats; Rats, Wistar; Up-Regulation | 2001 |
Resistance of immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling.
Topics: Aging; Animals; Animals, Newborn; Cell Count; Electric Stimulation; Excitatory Amino Acid Agonists; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; Male; Mossy Fibers, Hippocampal; Neural Inhibition; Neuronal Plasticity; Neurons; Perforant Pathway; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2001 |
Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment.
Topics: Aging; Animals; Brain Chemistry; Cell Count; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Lipid Peroxidation; Lipofuscin; Malondialdehyde; Mice; Mice, Inbred Strains; Microscopy, Electron; Nerve Tissue Proteins; Neurotoxicity Syndromes; Oxidative Stress; Seizures | 2002 |
Kainic acid alters neurochemical development in fetal rat brain aggregating cell cultures.
Topics: Acetylcholinesterase; Aging; Animals; Brain; Cell Aggregation; Choline O-Acetyltransferase; Cyclic GMP; Dopa Decarboxylase; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Kainic Acid; Monoamine Oxidase; Neurons; Organ Culture Techniques; Pyrrolidines; Rats; Tryptophan; Tyrosine 3-Monooxygenase | 1977 |
Susceptibility of rat neostriatum to damage by kainic acid: age dependence.
Topics: Aging; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Kainic Acid; Pyrrolidines; Rats | 1979 |
[3H]D-aspartic acid release in brain slices of adult and aged Fischer 344 rates.
Topics: Aging; Animals; Aspartic Acid; Brain; Calcium Channels; Electric Stimulation; Hippocampus; Kainic Acid; Male; omega-Conotoxin GVIA; Peptides, Cyclic; Rats; Rats, Inbred F344; Temporal Lobe | 1992 |
Effect of kainic acid administration to prepubescent rats on cholinergic markers in selected brain regions of adult rats.
Topics: Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Flunitrazepam; Kainic Acid; Male; Organ Specificity; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Muscarinic | 1992 |
Cortical AMPA receptors: age-dependent regulation by cellular depolarization and agonist stimulation.
Topics: Aging; Animals; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Male; Membrane Potentials; Muscimol; N-Methylaspartate; Neuronal Plasticity; Quisqualic Acid; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, AMPA; Receptors, Neurotransmitter; Veratridine | 1992 |
Effect of gamma-glutamyl transpeptidase inhibitors on the transport of glutamate into neuronal and glial primary cultures.
Topics: Aging; Animals; Biological Transport; Borates; Brain; Cells, Cultured; Chickens; Diazooxonorleucine; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Kainic Acid; Neuroglia; Neurons; Serine | 1992 |
Messenger RNAs coding for receptors and channels in the cerebral cortex of adult and aged rats.
Topics: Acetylcholine; Aging; Animals; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Male; Membrane Potentials; Oocytes; Poly A; Rats; Rats, Inbred F344; Receptors, Neurotransmitter; RNA, Messenger; Serotonin; Xenopus | 1992 |
Selective susceptibility of cultured striatal neurons to kainic acid.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Autoradiography; Cells, Cultured; Corpus Striatum; Glial Fibrillary Acidic Protein; Kainic Acid; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1992 |
The embryonic form of neural cell surface molecule (E-NCAM) in the rat hippocampus and its reexpression on glial cells following kainic acid-induced status epilepticus.
Topics: Aging; Animals; Animals, Newborn; Brain; Cell Adhesion Molecules, Neuronal; Embryo, Mammalian; Hippocampus; Immunoblotting; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Male; Neuroglia; Rats; Rats, Inbred Strains; Status Epilepticus; Tissue Distribution | 1992 |
Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures.
Topics: Aging; Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Electrodes; Electroencephalography; Flurothyl; Kainic Acid; Male; Myoclonus; Rats; Rats, Inbred Strains; Recurrence; Seizures; Status Epilepticus | 1992 |
Transient postnatal increases in excitatory amino acid binding sites in rat ventral mesencephalon.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Corpus Striatum; Glutamates; Ibotenic Acid; Kainic Acid; Mesencephalon; N-Methylaspartate; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
The deleterious effects of aging and kainic acid may be selective for similar striatal neuronal populations.
Topics: Acetylcholinesterase; Aging; Animals; Corpus Striatum; Enkephalin, Methionine; Kainic Acid; Neurons; Rats; Rats, Wistar; Receptors, Dopamine D2; Tyrosine 3-Monooxygenase | 1991 |
Changes in messenger RNAs coding for neurotransmitter receptors and voltage-operated channels in the developing rat cerebral cortex.
Topics: Aging; Animals; Cerebral Cortex; Electric Conductivity; Embryonic and Fetal Development; Female; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; Membrane Proteins; Microinjections; Oocytes; Poly A; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
Nutrition, neurotoxicants and age-related neurodegeneration.
Topics: Aging; Amino Acids; Animals; Avoidance Learning; Brain Diseases; Diet; Dietary Proteins; Energy Intake; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Rats; Rats, Inbred F344; Risk Factors; Trimethyltin Compounds | 1991 |
Development of intracellular calcium responses to depolarization and to kainate and N-methyl-D-aspartate in cultured mouse hippocampal neurons.
Topics: Aging; Animals; Calcium; Cells, Cultured; Hippocampus; Image Processing, Computer-Assisted; Kainic Acid; Magnesium; Membrane Potentials; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Video Recording | 1991 |
Glutamate neurotoxicity in the cochlea: a possible consequence of ischaemic or anoxic conditions occurring in ageing.
Topics: Aging; Animals; Cell Hypoxia; Cochlea; Glutamates; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Humans; Ischemia; Kainic Acid; Neurotransmitter Agents; Presbycusis; Vestibulocochlear Nerve | 1990 |
Neurotoxicity of kainic acid in the rat cochlea during early developmental stages.
Topics: Aging; Animals; Cochlea; Hair Cells, Auditory; Hair Cells, Auditory, Inner; Kainic Acid; Nerve Fibers; Neurons, Afferent; Organ of Corti; Rats; Rats, Inbred Strains; Synapses | 1990 |
Excitatory amino acid receptors on sustained retinal ganglion cells in the kitten during the critical period of development.
Topics: Action Potentials; Aging; Animals; Aspartic Acid; Cats; Kainic Acid; N-Methylaspartate; Oxadiazoles; Photic Stimulation; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Retinal Ganglion Cells; Visual Pathways | 1990 |
The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration.
Topics: Affinity Labels; Aging; Animals; Autoradiography; Brain; Brain Ischemia; Disease Models, Animal; Isoquinolines; Kainic Acid; Male; Mice; Nerve Degeneration; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Discrimination of heterogenous mRNAs encoding strychnine-sensitive glycine receptors in Xenopus oocytes by antisense oligonucleotides.
Topics: Aging; Animals; Base Sequence; beta-Alanine; Female; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Membrane Potentials; Molecular Sequence Data; Oligonucleotide Probes; Oocytes; Poly A; Protein Biosynthesis; Rats; Receptors, Glycine; Receptors, Neurotransmitter; RNA; RNA, Antisense; RNA, Messenger; Serotonin; Spinal Cord; Strychnine; Xenopus | 1989 |
Transient increase in ligand binding to quisqualate and kainate sites in cerebral cortex of immature rats.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebral Cortex; Ibotenic Acid; Kainic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1989 |
Effects of carbamazepine and phenobarbital on kainic acid-induced model of psychomotor seizures during ontogenesis in the rat.
Topics: Aging; Animals; Carbamazepine; Dose-Response Relationship, Drug; Kainic Acid; Male; Phenobarbital; Rats; Rats, Inbred Strains; Seizures | 1989 |
The binding properties and regional ontogeny for [3H]glutamic acid Na+-independent and [3H]kainic acid binding sites in chick brain.
Topics: Aging; Animals; Binding, Competitive; Brain; Chick Embryo; Chickens; Kainic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1986 |
Cellular uptake disguises action of L-glutamate on N-methyl-D-aspartate receptors. With an appendix: diffusion of transported amino acids into brain slices.
Topics: Aging; Animals; Aspartic Acid; Biological Transport; Brain; Cyclic GMP; Diffusion; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1985 |
Quisqualate-sensitive, chloride-dependent transport of glutamate into rat brain synaptosomes.
Topics: Aging; Animals; Anions; Brain; Corpus Striatum; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Male; Oxadiazoles; Potassium Chloride; Quisqualic Acid; Rats; Rats, Inbred Strains; Sodium Chloride; Synaptosomes | 1987 |
In vitro neurotoxicity of excitatory acid analogues during cerebellar development.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Female; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1986 |
Selective loss of Purkinje and granule cell responsiveness to N-methyl-D-aspartate in rat cerebellum during development.
Topics: Aging; Animals; Aspartic Acid; Cerebellum; Convulsants; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats | 1987 |
Kainic acid-induced eye enlargement in chickens: differential effects on anterior and posterior segments.
Topics: Aging; Animals; Animals, Newborn; Anterior Eye Segment; Chickens; Eye; Kainic Acid; Male; Refractive Errors | 1988 |
Effects of kainic acid on seizure susceptibility in the developing brain.
Topics: Aging; Animals; Brain; Electroencephalography; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Status Epilepticus | 1988 |
Intravitreal kainic acid severely reduces the size of the developing optic tectum in newly hatched chickens.
Topics: Aging; Animals; Chickens; Kainic Acid; Retina; Retinal Ganglion Cells; Superior Colliculi; Vitreous Body | 1987 |
Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels.
Topics: 3-Hydroxybutyric Acid; Adrenalectomy; Aging; Animals; Cell Survival; Corticosterone; Drug Synergism; Energy Metabolism; Fructose; Glucocorticoids; Glucose; Hippocampus; Hydroxybutyrates; Kainic Acid; Male; Mannose; Neurons; Pyridines; Rats; Rats, Inbred Strains | 1986 |
Role of target tissue in regulating the development of retinal ganglion cells in the albino rat: effects of kainate lesions in the superior colliculus.
Topics: Aging; Animals; Cell Count; Horseradish Peroxidase; Ibotenic Acid; Kainic Acid; Microinjections; Nerve Crush; Nerve Degeneration; Neurotoxins; Rats; Rats, Inbred Strains; Retina; Retinal Ganglion Cells; Superior Colliculi; Time Factors; Visual Pathways | 1986 |
Reactive synaptogenesis in hippocampal area CA1 of aged and young adult rats.
Topics: Aging; Animals; Brain Diseases; Hippocampus; Kainic Acid; Male; Microscopy, Electron; Neuronal Plasticity; Rats; Rats, Inbred F344; Synapses | 1986 |
Long-term effects of febrile convulsion on seizure susceptibility in P77PMC rat--resistant to acoustic stimuli but susceptible to kainate-induced seizures.
Topics: Acoustic Stimulation; Aging; Animals; Disease Susceptibility; Female; Fever; Immunity, Innate; Kainic Acid; Male; Rats; Rats, Inbred Strains; Reaction Time; Seizures; Time Factors | 1985 |