jzl195 and Stroke

jzl195 has been researched along with Stroke* in 1 studies

Other Studies

1 other study(ies) available for jzl195 and Stroke

Article	Year
Long-term depression induced by endogenous cannabinoids produces neuroprotection via astroglial CB Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019, Volume: 39, Issue:6 Ischemia not only activates cell death pathways but also triggers endogenous protective mechanisms. However, it is largely unknown what is the essence of the endogenous neuroprotective mechanisms induced by preconditioning. In this study we demonstrated that systemic injection of JZL195, a selective inhibitor of eCB clearance enzymes, induces in vivo long-term depression at CA3-CA1 synapses and at PrL-NAc synapses produces neuroprotection. JZL195-elicited long-term depression is blocked by AM281, the antagonist of cannabinoid 1 receptor (CB Topics: Animals; Astrocytes; Cannabinoids; Carbamates; Long-Term Synaptic Depression; Mice; Neuroprotection; Piperazines; Receptor, Cannabinoid, CB1; Receptors, Glutamate; Rodentia; Stroke	2019

Article

Year

Long-term depression induced by endogenous cannabinoids produces neuroprotection via astroglial CB

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2019, Volume: 39, Issue:6

Ischemia not only activates cell death pathways but also triggers endogenous protective mechanisms. However, it is largely unknown what is the essence of the endogenous neuroprotective mechanisms induced by preconditioning. In this study we demonstrated that systemic injection of JZL195, a selective inhibitor of eCB clearance enzymes, induces in vivo long-term depression at CA3-CA1 synapses and at PrL-NAc synapses produces neuroprotection. JZL195-elicited long-term depression is blocked by AM281, the antagonist of cannabinoid 1 receptor (CB

Topics: Animals; Astrocytes; Cannabinoids; Carbamates; Long-Term Synaptic Depression; Mice; Neuroprotection; Piperazines; Receptor, Cannabinoid, CB1; Receptors, Glutamate; Rodentia; Stroke

2019