Compounds > isoxazoles
Page last updated: 2024-08-21

isoxazoles and Edema

isoxazoles has been researched along with Edema in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19906 (13.64)18.7374
1990's7 (15.91)18.2507
2000's15 (34.09)29.6817
2010's14 (31.82)24.3611
2020's2 (4.55)2.80

Authors

AuthorsStudies
Alves, D; Barcellos, T; da Silva, MS; Dalberto, B; Lenardão, EJ; Lopes, EF; Luchese, C; Penteado, F; Pinz, M; Reis, AS; Thurow, S; Wilhelm, EA1
Abdelall, EKA1
Balaini, A; Bali, A; Chaudhari, BB1
Ahmed, M; Hameed, A; Imran, M; Muddassar, M; Qadir, MA1
Govardhan Reddy, K; Nagaraju, D; Rajanarendar, E; Ramakrishna, S; Reddy, YN1
Abdel Wahab, AE; El-Ashmawey, IM; El-Hawash, SA; Elzahhar, PA; Ragab, HM; Shaat, IA; Soliman, R; Youssef, AM1
Chen, HJ; Cheng, KD; Hsu, HC; Lin, ST; Tsang, HY1
Gotoh, M; Morohoshi, T; Murakami-Murofushi, K; Murofushi, H; Nagano, A; Otsuka, K; Tsukahara, R1
Govardhan Reddy, K; Kishore, B; Nagaraju, D; Rajanarendar, E; Rama Krishna, S; Reddy, YN1
Fowler, N; Hagemeister, F; Knickerbocker, J; Kwak, L; Nastoupil, L; Oki, Y; Romaguera, J; Samaniego, F; Westin, J; Younes, A1
Asirvatham, S; Mahajan, S1
Artym, J; Kochanowska, I; Kocięba, M; Mączyński, M; Ryng, S; Zimecki, M1
Herschman, HR; Ishikawa, TO; Jain, NK; Spigelman, I1
Safdar, Z1
Barry, GD; Cotterell, AJ; Fairlie, DP; Halili, MA; Le, GT; Lohman, RJ; Suen, JY1
Jain, S; Özadalı, K; Özkanlı, F; Rao, PP; Velázquez-Martínez, CA1
Nagi Reddy, M; Rajam, MV; Rajanarendar, E; Rama Krishna, S; Rama Murthy, K; Reddy, YN1
Chiu, HF; Huang, WH; Lee, AR; Yang, CL1
Jain, NK; Kulkarni, SK; Padi, SS; Singh, S1
Ruppen, W; Schüpfer, GK1
Madhusudan, S; Pralhad, T; Rajendrakumar, K1
Mallesha, H; Nataraju, A; Rajesh, R; Rangappa, KS; Sadashiva, MP; Vishwanath, BS1
Khan, MO; Ko, DH; Lee, HJ; Park, KK; You, Z1
Fischer, J; Kis-Varga, A; Szabó, G1
Joshi, M; Patravale, V1
Deray, G; Héloire, F; Valat, JP1
Ilavarasan, R; Kesavanarayanan, KS; Nappinnai, M1
Benetello, V; Calvo, AM; Colombini, BL; Dionísio, TJ; Faria, FA; Giglio, FP; Lauris, JR; Modena, KC; Sakai, VT; Sakamoto, FC; Santos, CF1
Ahmed, AA; Albert, DH; Bouska, JJ; Bousquet, PF; Cunha, GA; Davidsen, SK; Diaz, G; Glaser, KB; Guo, J; Harris, CM; Ji, Z; Li, J; Marcotte, PA; Michaelides, MR; Moskey, MD; Oie, T; Pease, L; Soni, NB; Stewart, KD1
Czugler, M; Erdélyi, P; Fischer, J; Fodor, T; Gere, A; Varga, AK1
Heiman, AS; Kwon, T; Lee, HJ; Oriaku, ET; Yoon, K1
Fossa, P; Mattioli, F; Menozzi, G; Schenone, P1
Connolly, KM; Noel, LS; Smith-Oliver, T; Stimpson, SS; Yarnall, DP1
Arshad, F; Bailey, SC; Kurtz, ES; Lee, AA; Przekop, PA1
Ko, DH; Lee, HJ1
Brown, DL; Carter, JS; Graneto, MJ; Koboldt, CM; Masferrer, JL; Perkins, WE; Rogers, RS; Seibert, K; Shaffer, AF; Talley, JJ; Zhang, YY; Zweifel, BS1
Diamantis, W; Ludwig, BJ; Sofia, RD2
Saunders, JC; Williamson, WR1
Sofia, RD1
Bekemeier, H; Giessler, J; Pilopp, H; Schmidt, K1
Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y1
Georgiev, VS; Mullen, GB; Swift, PA1
Bajardi, ML; Daidone, G; Plescia, S; Raffa, D1

Reviews

2 review(s) available for isoxazoles and Edema

ArticleYear
Paliperidone-related peripheral edema: a case report and review of the literature.
    Journal of clinical psychopharmacology, 2014, Volume: 34, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Child; Edema; Female; Humans; Isoxazoles; Male; Middle Aged; Paliperidone Palmitate; Pyrimidines; Young Adult

2014
[Are there any differences in the cardiovascular tolerance between classical NSAIDs and coxibs?].
    Presse medicale (Paris, France : 1983), 2006, Volume: 35, Issue:9 Spec No

    Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Case-Control Studies; Celecoxib; Cohort Studies; Cyclooxygenase 2 Inhibitors; Diclofenac; Edema; Heart Failure; Humans; Hypertension; Isoxazoles; Lactones; Meta-Analysis as Topic; Middle Aged; Odds Ratio; Placebos; Prospective Studies; Pyrazoles; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonamides; Sulfones; Thrombosis; Time Factors

2006

Trials

2 trial(s) available for isoxazoles and Edema

ArticleYear
Experience with HSP90 inhibitor AUY922 in patients with relapsed or refractory non-Hodgkin lymphoma.
    Haematologica, 2015, Volume: 100, Issue:7

    Topics: Antineoplastic Agents; Diarrhea; Drug Administration Schedule; Edema; Fatigue; Female; Gene Expression; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Male; Recurrence; Remission Induction; Resorcinols; Retrospective Studies; Survival Analysis; Thrombocytopenia; Treatment Outcome

2015
The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2007, Volume: 40, Issue:8

    Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Edema; Female; Humans; Isoxazoles; Male; Molar, Third; Pain, Postoperative; Piroxicam; Sulfonamides; Tooth Extraction; Treatment Outcome; Trismus

2007

Other Studies

40 other study(ies) available for isoxazoles and Edema

ArticleYear
Synthesis of Isoxazolines by the Electrophilic Chalcogenation of β,γ-Unsaturated Oximes: Fishing Novel Anti-Inflammatory Agents.
    The Journal of organic chemistry, 2019, 10-04, Volume: 84, Issue:19

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Croton Oil; Dose-Response Relationship, Drug; Ear; Edema; Isoxazoles; Male; Mice; Molecular Structure; Oximes

2019
Synthesis and biological evaluations of novel isoxazoles and furoxan derivative as anti-inflammatory agents.
    Bioorganic chemistry, 2020, Volume: 94

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Isoxazoles; Molecular Structure; Oxadiazoles; Rats; Rats, Wistar; Structure-Activity Relationship

2020
Design and Synthesis of Novel Anti-inflammatory/Anti-ulcer Hybrid Molecules with Antioxidant Activity.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2021, Volume: 17, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Chalcone; Drug Design; Drug Evaluation, Preclinical; Edema; Female; Isoxazoles; Male; Molecular Structure; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship

2021
Screening of curcumin-derived isoxazole, pyrazoles, and pyrimidines for their anti-inflammatory, antinociceptive, and cyclooxygenase-2 inhibition.
    Chemical biology & drug design, 2018, Volume: 91, Issue:1

    Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Binding Sites; Catalytic Domain; Curcumin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Humans; Isoxazoles; Mice; Molecular Docking Simulation; Protein Binding; Pyrazoles; Pyrimidines; Stomach; Structure-Activity Relationship

2018
A facile synthesis, anti-inflammatory and analgesic activity of isoxazolyl-2,3-dihydrospiro[benzo[f]isoindole-1,3'-indoline]-2',4,9-triones.
    Bioorganic & medicinal chemistry letters, 2013, Jul-01, Volume: 23, Issue:13

    Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationship, Drug; Edema; Female; Isoindoles; Isoxazoles; Male; Molecular Conformation; Rats; Rats, Wistar

2013
Design, synthesis and biological screening of some pyridinylpyrazole and pyridinylisoxazole derivatives as potential anti-inflammatory, analgesic, antipyretic and antimicrobial agents.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2014, Volume: 10, Issue:3

    Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Design; Edema; Escherichia coli; Formaldehyde; Isoxazoles; Male; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pseudomonas aeruginosa; Pyrazoles; Pyridines; Rats; Rats, Wistar; Structure-Activity Relationship

2014
Cyclic phosphatidic acid relieves osteoarthritis symptoms.
    Molecular pain, 2014, Aug-14, Volume: 10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokines; Disease Models, Animal; Edema; Female; Follow-Up Studies; Humans; Isoxazoles; Joint Capsule; Male; Middle Aged; Osteoarthritis; Pain Measurement; Phosphatidic Acids; Propionates; Rabbits; RNA, Messenger; Synovial Membrane; Time Factors

2014
Environmentally benign synthesis, molecular properties prediction and anti-inflammatory activity of novel isoxazolo[5,4-d]isoxazol-3-yl-aryl-methanones via vinylogous Henry nitroaldol adducts as synthons.
    Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Heterocyclic Compounds, 3-Ring; Isoxazoles; Molecular Structure; Nitro Compounds; Rats; Rats, Wistar; Structure-Activity Relationship

2015
Synthesis, Biological Evaluation and QSAR Studies of Newer Isoxazole Derivatives.
    Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2015, Volume: 14, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Chalcones; Edema; Female; Hydroxylamine; Indomethacin; Isoxazoles; Male; Quantitative Structure-Activity Relationship; Rats; Rats, Wistar

2015
Anti-inflammatory properties of an isoxazole derivative - MZO-2.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Proliferation; Cells, Cultured; Edema; Female; Humans; Hypersensitivity, Delayed; Immunity, Humoral; Inflammation; Isoxazoles; Leukocytes, Mononuclear; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Ovalbumin; Phytohemagglutinins; Sheep; Tumor Necrosis Factor-alpha

2016
COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.
    Prostaglandins, leukotrienes, and essential fatty acids, 2008, Volume: 79, Issue:6

    Topics: Animals; Blotting, Western; Brain; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Gene Expression Regulation, Enzymologic; Hindlimb; Hyperalgesia; Inflammation; Isoxazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Zymosan

2008
Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension.
    Vascular health and risk management, 2011, Volume: 7

    Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Drug Substitution; Dyspnea; Edema; Endothelin A Receptor Antagonists; Exercise Test; Exercise Tolerance; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Isoxazoles; Liver Function Tests; Male; Middle Aged; Natriuretic Peptide, Brain; Oxygen; Phenylpropionates; Pyridazines; Retrospective Studies; Texas; Thiophenes; Time Factors; Treatment Outcome; Walking

2011
Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110).
    British journal of pharmacology, 2012, Volume: 165, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Calcium; Cell Line; Dipeptides; Edema; HT29 Cells; Humans; Inflammation; Isoxazoles; Oligopeptides; Peptides; Piperidines; Rats; Receptor, PAR-1; Receptor, PAR-2; Spiro Compounds; Trypsin

2012
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
    Bioorganic & medicinal chemistry, 2012, May-01, Volume: 20, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Binding Sites; Catalytic Domain; Computer Simulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Enzyme Activation; Humans; Isoxazoles; Lipoxygenase Inhibitors; Protein Binding; Pyridazines; Rats

2012
Design, synthesis, antimicrobial, anti-inflammatory and analgesic activity of novel isoxazolyl pyrimido[4,5-b]quinolines and isoxazolyl chromeno[2,3-d]pyrimidin-4-ones.
    European journal of medicinal chemistry, 2012, Volume: 55

    Topics: Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Behavior, Animal; Chemistry Techniques, Synthetic; Drug Design; Edema; Fungi; Isoxazoles; Microbial Sensitivity Tests; Pyrimidinones; Quinolines; Rats

2012
Leflunomide analogues as potential antiinflammatory agents.
    Chemical & pharmaceutical bulletin, 2003, Volume: 51, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Edema; Inflammation; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley

2003
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
    European journal of pharmacology, 2004, Apr-26, Volume: 491, Issue:1

    Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Endotoxins; Female; Fever; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Mice; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach

2004
Exacerbation of carpal tunnel syndrome under treatment with valdecoxib.
    Anesthesia and analgesia, 2005, Volume: 100, Issue:4

    Topics: Adult; Carpal Tunnel Syndrome; Contusions; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Humans; Isoxazoles; Knee Injuries; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Sulfonamides

2005
Cyclodextrin complexes of valdecoxib: properties and anti-inflammatory activity in rat.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2005, Volume: 60, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Circular Dichroism; Cyclodextrins; Edema; Excipients; Isoxazoles; Kinetics; Magnetic Resonance Spectroscopy; Rats; Solubility; Spectroscopy, Fourier Transform Infrared; Sulfonamides; X-Ray Diffraction

2005
Synthesis and evaluation of trimethoxyphenyl isoxazolidines as inhibitors of secretory phospholipase A2 with anti-inflammatory activity.
    International journal of molecular medicine, 2005, Volume: 16, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Enzyme Inhibitors; Group II Phospholipases A2; Isoxazoles; Mice; Mice, Inbred Strains; Molecular Structure; Phospholipases A; Phospholipases A2

2005
In vitro anti-inflammatory activities of new steroidal antedrugs: [16alpha,17alpha-d] Isoxazoline and [16alpha,17alpha-d]-3'-hydroxy-iminoformyl isoxazoline derivatives of prednisolone and 9alpha-fluoroprednisolone.
    Steroids, 2006, Volume: 71, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Cytosol; Ear Diseases; Edema; In Vitro Techniques; Isoxazoles; Lipopolysaccharides; Liver; Macrophages; Male; Nitric Oxide; Prednisolone; Pregnadienetriols; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid

2006
Synthesis of the pyrazole isostere of valdecoxib.
    Die Pharmazie, 2006, Volume: 61, Issue:6

    Topics: Animals; Carrageenan; Cyclooxygenase 2 Inhibitors; Edema; Foot; Indicators and Reagents; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Pyrazoles; Rats; Rats, Wistar; Sulfonamides

2006
Formulation and evaluation of Nanostructured Lipid Carrier (NLC)-based gel of Valdecoxib.
    Drug development and industrial pharmacy, 2006, Volume: 32, Issue:8

    Topics: Animals; Chemistry, Pharmaceutical; Drug Carriers; Edema; Gels; Isoxazoles; Lipids; Male; Nanostructures; Rabbits; Rats; Rats, Wistar; Skin Irritancy Tests; Solubility; Sulfonamides

2006
Topical dosage form of valdecoxib: preparation and pharmacological evaluation.
    Acta pharmaceutica (Zagreb, Croatia), 2007, Volume: 57, Issue:2

    Topics: Acrylic Resins; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Dose-Response Relationship, Drug; Drug Compounding; Drug Evaluation, Preclinical; Drug Stability; Edema; Gels; Hindlimb; Hydrogen-Ion Concentration; Hyperalgesia; Isoxazoles; Male; Ointments; Pain Measurement; Rats; Rats, Wistar; Skin Irritancy Tests; Sulfonamides; Surface Properties; Time Factors; Treatment Outcome

2007
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
    Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Binding Sites; Biological Availability; Capillary Permeability; Cell Line; Cell Line, Tumor; Edema; Female; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Models, Molecular; NIH 3T3 Cells; Oxazoles; Phenylurea Compounds; Phosphorylation; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Structure-Activity Relationship; Uterus; Xenograft Model Antitumor Assays

2008
Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib.
    Bioorganic & medicinal chemistry, 2008, May-01, Volume: 16, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cattle; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; Hyperalgesia; Inflammation; Isoxazoles; Male; Models, Molecular; Molecular Structure; Pain; Pain Measurement; Rabbits; Rats; Rats, Wistar; Recombinant Proteins; Stereoisomerism; Sulfonamides; Time Factors

2008
New steroidal antiinflammatory antedrugs: steroidal [16 alpha,17 alpha-d]-3'-carbethoxyisoxazolines.
    Journal of medicinal chemistry, 1995, Mar-17, Volume: 38, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Croton Oil; Dose-Response Relationship, Drug; Drug Administration Schedule; Ear, External; Edema; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Steroids

1995
5-substituted 4-isoxazoleacetic acids with analgesic activity.
    Farmaco (Societa chimica italiana : 1989), 1994, Volume: 49, Issue:1

    Topics: Acetates; Analgesics; Animals; Behavior, Animal; Carrageenan; Edema; Isoxazoles; Lethal Dose 50; Magnetic Resonance Spectroscopy; Mice; Pain Measurement; Rats; Spectrophotometry, Infrared

1994
Elevated levels of TNF in the joints of adjuvant arthritic rats.
    Cytokine, 1993, Volume: 5, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Assay; Cells, Cultured; Cyclosporine; Edema; Freund's Adjuvant; Ibuprofen; Isoxazoles; Joints; L Cells; Leflunomide; Macrophages, Peritoneal; Male; Methotrexate; Mice; Mycobacterium tuberculosis; Rabbits; Rats; Rats, Inbred Lew; Tumor Necrosis Factor-alpha

1993
Leflunomide: an active antiinflammatory and antiproliferative agent in models of dermatologic disease.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bromodeoxyuridine; Cell Division; Chronic Disease; Edema; Humans; Isoxazoles; Leflunomide; Leukotriene B4; Male; Mice; Mice, Inbred Strains; Neutral Red; Peroxidase; Phorbol Esters; Skin Diseases

1995
A novel approach to the discovery of non-systemic anti-inflammatory steroids; antedrug.
    Archives of pharmacal research, 1999, Volume: 22, Issue:3

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Body Weight; Carboxylic Acids; Corticosterone; Croton Oil; Drug Evaluation; Ear Diseases; Edema; Isoxazoles; Male; Organ Size; Prednisolone; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley

1999
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.
    Journal of medicinal chemistry, 2000, Mar-09, Volume: 43, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase 2; Edema; Enzyme Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Recombinant Proteins; Sulfonamides

2000
Pharmacological properties of 2,3-dihydro-9H-isoxazolo [3,2-b] quinazolin-9-one (W-2429. Part 1: Analgesic, antipyretic and antiedema activity.
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:4

    Topics: Administration, Oral; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Body Temperature; Dextropropoxyphene; Drug Interactions; Drug Tolerance; Edema; Fever; Humans; Injections, Intravenous; Isoxazoles; Lethal Dose 50; Male; Mice; Narcotic Antagonists; Oxazoles; Quinazolines; Rats; Substance-Related Disorders; Time Factors

1977
Potential antiinflammatory compounds. 2. Acidic antiinflammatory 1,2-benzisoxazoles.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Isoxazoles; Oxazoles; Rats; Structure-Activity Relationship

1979
Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models.
    Pharmacology, 1978, Volume: 16, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Benzoxazines; Drug Evaluation, Preclinical; Edema; Hydrocortisone; Indomethacin; Isoxazoles; Male; Oxazines; Phenylbutazone; Rats; Salicylates

1978
Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats.
    Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:8

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Body Temperature; Edema; Isoxazoles; Male; Oxazines; Oxazoles; Rats; Salicylates; Stomach Ulcer

1975
Immunomodulating effects of T-44 in comparison to HWA 486.
    Agents and actions, 1991, Volume: 32, Issue:1-2

    Topics: 1-Naphthylamine; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclosporins; Edema; Female; Graft vs Host Reaction; Hypersensitivity, Delayed; Isoxazoles; Leflunomide; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Picryl Chloride

1991
[Pharmacological profile of mofezolac, a new non-steroidal analgesic anti-inflammatory drug].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1990, Volume: 95, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Capillary Permeability; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Isoxazoles; Mice; Organ Size; Oxazoles; Platelet Aggregation Inhibitors; Rabbits; Rats

1990
Substituted spiro[isoxazolidine-3,2'-tricyclo[3.3.1.1(3,7)]decane] derivatives.
    Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Chemistry; Edema; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Spiro Compounds

1987
Potential biologically active agents. Note II. Synthesis and pharmacological evaluation of some new 3-isoxazolyl-substituted-1,2,3-benzotriazin-4(3H)-ones.
    Bollettino chimico farmaceutico, 1985, Volume: 124, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Edema; Isoxazoles; Oxazoles; Rats; Rats, Inbred Strains; Triazines

1985