isoxazoles has been researched along with Ache in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (9.64) | 18.7374 |
| 1990's | 5 (6.02) | 18.2507 |
| 2000's | 42 (50.60) | 29.6817 |
| 2010's | 26 (31.33) | 24.3611 |
| 2020's | 2 (2.41) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, L; Wang, C; Wu, Z; Xu, H; Yao, Y; Zheng, F; Zhou, J | 1 |
| Ahmed, S; Anwar, T; Arif, M; Khan, A; Nadeem, H; Naureen, H; Sarwar, S | 1 |
| Aikawa, Y; Ito, H; Kawaguchi, Y; Kimura, T; Makino, H; Motomura, H; Nogami, M; Sainoh, T; Seki, S; Shiozawa, S; Tsumaki, N; Watanabe, K; Yahara, Y; Yamazaki, M | 1 |
| Duan, XL; He, YT; Hu, XD; Liu, JP; Suo, ZW; Yang, X | 1 |
| Song, ZS; Sun, JY; Xiao, XY; Zhang, XP | 1 |
| Bartzatt, R | 1 |
| Li, H; Liu, Y; Rui, Q; Shu, L; Si, T; Su, Y; Zhang, H | 1 |
| Kong, Y; Yang, X | 1 |
| Mejia, GL; Pasteris, RJ; Pember, SO; Price, TJ | 1 |
| Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM | 1 |
| Brack, A; Broscheit, JA; Rittner, HL; Roewer, N; Sauer, RS; Shityakov, S; Sohajda, T | 1 |
| Jia, Y; Miao, H; Wang, L; Yang, Y; Zhang, XY; Zhou, YS | 1 |
| Bhatti, R; Gupta, V; Mahajan, A; Singh Ishar, MP; Singh, G; Singh, P | 1 |
| Murakami, T; Ono, H; Tanabe, M | 1 |
| Herrndobler, F; Koppert, W; Maihöfner, C; Ringler, R | 1 |
| Abbadie, C; Felix, JP; Gao, YD; Garcia, ML; Kaczorowski, GJ; Li, X; Lyons, KA; Martin, WJ; McGowan, E; McMasters, DR; Parsons, WH; Priest, BT; Shao, PP; Smith, MM; Weber, AE; Williams, BS; Ye, F | 2 |
| Angst, MS; Bradshaw, MH; Felden, L; Geisslinger, G; Greer, JJ; Johnson, S; Lötsch, J; Oertel, BG; Schmidt, H; Tran, PV; Varney, MA | 1 |
| Li, XX; Peng, YZ; Wang, YW | 1 |
| Mateos, JL | 1 |
| Bala, I; Ghai, B; Makkar, JK; Wig, J | 1 |
| Gopal, S; Herben, V; Kusumakar, V; Lim, P; Lindenmayer, JP; Lull, J; Palumbo, J; Pandina, GJ; Yuen, E | 1 |
| Perrone, MG; Scilimati, A; Simone, L; Vitale, P | 1 |
| Gao, ZY; Gong, N; Hashimoto, K; Huang, JL; Li, XY; Wang, YC; Wang, YX | 1 |
| Draegni, T; Heyerdahl, F; Lenz, H; Raeder, J; Schmelz, M; Stubhaug, A | 1 |
| Abernethy, L; Clarkson, T; Dempster, M; Easson, AM; Edwards, D; Everett, K; Feilden, H; Littlewood, P; Maclean, J; McArthur, D; McGregor, D; McLuskey, H; Nimz, O; Nisbet, LA; Palin, R; Ratcliffe, P; Tracey, H; Walker, G | 1 |
| Arvidsson, PI; Besidski, Y; Bueters, T; Bylund, J; Eriksson, AB; Ginman, T; Gravenfors, Y; Lund, PE; Macsari, I; Sandberg, L; Venyike, E | 1 |
| Gong, N; Lu, JM; Wang, YC; Wang, YX | 1 |
| Gong, N; Hashimoto, K; Ma, AN; Wang, HL; Wang, YC; Wang, YX | 1 |
| Liu, J; Xiang, Y; Zhang, Y | 1 |
| Chen, XL; Guo, C; Huang, JL; Wang, YX | 1 |
| Carroll, FI; Damaj, MI; Freitas, K | 1 |
| Bible, R; Findlay, JW; Karim, A; Yang, DC; Yuan, JJ; Zhang, JY | 1 |
| Backonja, MM | 1 |
| Ormrod, D; Wagstaff, AJ; Wellington, K | 1 |
| Hayes, EC; Rock, JA | 1 |
| Rowbotham, DJ | 1 |
| Korttila, K | 1 |
| Alsalameh, S; Burian, M; Geisslinger, G; Mahr, G; Woodcock, BG | 1 |
| Amara, I; Cohen, S; Crawford, B; Felson, D; Koch, G; Pincus, T; Strand, V; Wolfe, F | 1 |
| Goldstein, JL; Kent, JD; Kivitz, AJ; Palmer, RC; Recker, DP; Verburg, KM | 1 |
| Burian, M; Geisslinger, G | 1 |
| Bevan, S; Courade, JP; Dawson, J; Fox, A; Glatt, M; Gonzalez, I; Medhurst, S; Urban, L | 1 |
| Granados, J; Jakez-Ocampo, J; Llorente, L; Richaud-Patin, Y; Sánchez-Guerrero, J | 1 |
| Jain, NK; Kulkarni, SK; Padi, SS; Singh, S | 1 |
| Hashimoto, K; Takahashi, Y; Tsuji, S | 1 |
| Hasegawa, H | 1 |
| Harris, SI; Hubbard, RC; LeComte, D; Stoltz, RR | 1 |
| Boggie, DT; Delattre, ML; Morreale, AP; Plowman, BK; Schaefer, MG; Tran, F | 1 |
| Guay, DR | 1 |
| Gulla, J; Lovell, SJ; Rodriguez, E; Singer, AJ; Taira, T; Wackett, A | 1 |
| Taéron, C | 1 |
| Querna, E | 1 |
| Joshi, GP | 1 |
| Dalpiaz, AS; Peterson, D | 1 |
| Lang, L | 1 |
| Honda, M; Ono, H; Sakaue, A; Takasu, K; Tanabe, M | 1 |
| Zareba, G | 1 |
| Bouhassira, D; Chauvin, M; Fletcher, D; Martin, F | 1 |
| Bey, M; Kohles, JD; Pan, S; Sanner, KM; Schachtel, BP; Schachtel, EP | 1 |
| Anagnostou, T; Gravas, S; Karatzas, A; Melekos, MD; Mitsogiannis, IC; Poulakis, V; Tzortzis, V | 1 |
| Czugler, M; Erdélyi, P; Fischer, J; Fodor, T; Gere, A; Varga, AK | 1 |
| Sawynok, J | 1 |
| Kjaer, M; Nielsen, H | 1 |
| Følsgård, S; Jacobsen, E; Kehlet, H; Lindeburg, T; Sillesen, H | 1 |
| Clark, WG; Menon, MK; Vivonia, C | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Manelli, AM; Puttfarcken, PS | 1 |
| Kusuhara, H; Matsuyuki, H; Okumoto, T | 1 |
| Goto, K; Imayoshi, T; Kusuhara, H; Matsuyuki, H; Ochi, H; Okumoto, T; Yasunaga, Y | 1 |
| Ghanipoor, N; Parvini, S; Rezayat, M; Zarrindast, MR | 1 |
| Parvini, S; Pirali, M; Rezayat, M; Tabarrai, E; Zarrindast, MR | 1 |
| Debroe, S; Hewitson, PJ; McBride, A; Milne, R | 1 |
| Cheer, SM; Goa, KL | 1 |
| Baum, D; Desjardins, PJ; Dhadda, S; Grossman, EH; Hubbard, RC; Kuss, ME; Talwalker, S | 1 |
| Hiida, M; Hoshi, K | 1 |
| Dafny, N; Enna, SJ; Reyes-Vazquez, C | 1 |
| Enna, SJ; Zorn, SH | 1 |
| Drower, EJ; Hammond, DL | 1 |
| Pelley, KA; Vaught, JL | 1 |
14 review(s) available for isoxazoles and Ache
| Article | Year |
|---|---|
[Selective inhibitors of cyclooxygenase-2 (COX-2), celecoxib and parecoxib: a systematic review].
Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Administration Routes; Evidence-Based Medicine; Humans; Inflammation; Isoxazoles; Pain; Pain Measurement; Pyrazoles; Structure-Activity Relationship; Sulfonamides; Treatment Outcome | 2010 |
Selective COX-1 inhibition: A therapeutic target to be reconsidered.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Endothelial Cells; Female; Humans; Isoxazoles; Neoplasms; Nervous System Diseases; Obstetric Labor, Premature; Pain; Pregnancy | 2010 |
Use of anticonvulsants for treatment of neuropathic pain.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nervous System Diseases; Pain; Phenytoin; Triazines; Zonisamide | 2002 |
Valdecoxib.
Topics: Arthritis; Clinical Trials as Topic; Dysmenorrhea; Female; Humans; Isoxazoles; Pain; Sulfonamides | 2002 |
COX-2 inhibitors and their role in gynecology.
Topics: Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Administration Schedule; Dysmenorrhea; Endometriosis; Female; Genital Diseases, Female; Humans; Infertility, Female; Isoenzymes; Isoxazoles; Labor, Obstetric; Membrane Proteins; Menorrhagia; Menstrual Cycle; Ovary; Ovulation; Pain; Polycystic Ovary Syndrome; Pregnancy; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
COX-2-selective inhibitors: clinical relevance in surgical and acute pain.
Topics: Acute Disease; Analgesics; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain; Pain, Postoperative; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides | 2002 |
Review article: The pharmacological properties and clinical use of valdecoxib, a new cyclo-oxygenase-2-selective inhibitor.
Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biological Availability; Bone Diseases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Interactions; Dysmenorrhea; Female; Humans; Isoenzymes; Isoxazoles; Liver Diseases; Male; Membrane Proteins; Middle Aged; Mouth Diseases; Osteoarthritis; Pain; Prostaglandin-Endoperoxide Synthases; Rats; Sulfonamides | 2003 |
[Clinical pharmacology of the selective COX-2 inhibitors].
Topics: Acute Disease; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Isoxazoles; Lactones; Naproxen; Osteoarthritis; Pain; Pain, Postoperative; Placebos; Pyrazoles; Sulfonamides; Sulfones | 2003 |
Oxcarbazepine, topiramate, zonisamide, and levetiracetam: potential use in neuropathic pain.
Topics: Aged; Analgesics, Non-Narcotic; Animals; Carbamazepine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Fructose; Humans; Isoxazoles; Levetiracetam; Oxcarbazepine; Pain; Peripheral Nervous System Diseases; Piracetam; Topiramate; Zonisamide | 2003 |
Valdecoxib for the management of chronic and acute pain.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Drug Evaluation; Expert Testimony; Humans; Isoxazoles; Narcotics; Pain; Product Surveillance, Postmarketing; Sulfonamides | 2005 |
Parecoxib: a shift in pain management?
Topics: Animals; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Humans; Isoxazoles; Pain; Pain Measurement | 2004 |
Zonisamide: review of its use in epilepsy therapy.
Topics: Animals; Anticonvulsants; Biological Availability; Child; Child, Preschool; Drug Interactions; Epilepsy; Half-Life; Humans; Infant; Isoxazoles; Migraine Disorders; Pain; Parkinson Disease; Randomized Controlled Trials as Topic; Tissue Distribution; Zonisamide | 2005 |
Leflunomide and rheumatoid arthritis: a systematic review of effectiveness, safety and cost implications.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Cost-Benefit Analysis; Disease Progression; Drug Costs; Humans; Isoxazoles; Leflunomide; Pain; Treatment Outcome | 2000 |
[Rheumatic pain].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Cytokines; Etanercept; Humans; Immunoglobulin G; Infliximab; Isoxazoles; Leflunomide; Neoplasm Proteins; Pain; Pain Management; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Steroids; Tumor Necrosis Factor Decoy Receptors | 2001 |
18 trial(s) available for isoxazoles and Ache
| Article | Year |
|---|---|
Efficacy and Safety of COX-2 Inhibitor Parecoxib for Rigid Cystoscopy-related Pain Management in Male Patients: A Prospective, Randomized and Controlled Study.
Topics: Ambulatory Care Facilities; Cyclooxygenase 2 Inhibitors; Cystoscopy; Double-Blind Method; Humans; Injections, Intramuscular; Isoxazoles; Male; Middle Aged; Pain; Pain Management; Pain Measurement; Prospective Studies; Tetracaine; Treatment Outcome | 2019 |
Pharmacokinetics and tolerability of paliperidone palmitate injection in Chinese subjects.
Topics: Antipsychotic Agents; Asian People; Chromatography, High Pressure Liquid; Constipation; Dose-Response Relationship, Drug; Female; Humans; Injections, Intramuscular; Isoxazoles; Linear Models; Male; Middle Aged; Pain; Paliperidone Palmitate; Palmitates; Prolactin; Schizophrenia; Tandem Mass Spectrometry; Time Factors; Treatment Outcome; Tremor | 2014 |
[Study on the preemptive analgesia effects of both the parecoxib sodium and the pentazocine in patients undergoing nasal endoscopic surgery].
Topics: Analgesia; Analgesics; Double-Blind Method; Endoscopy; Humans; Isoxazoles; Nasal Surgical Procedures; Nose; Pain; Pain, Postoperative; Pentazocine | 2014 |
[Modulation of cortical pain processing by cyclooxygenase inhibition: a functional MRI study].
Topics: Acute Disease; Adult; Analgesics; Aspirin; Brain Mapping; Cerebral Cortex; Cyclooxygenase Inhibitors; Dominance, Cerebral; Double-Blind Method; Female; Frontal Lobe; Gyrus Cinguli; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Isoxazoles; Magnetic Resonance Imaging; Male; Motor Cortex; Pain; Pain Measurement; Pain Threshold; Parietal Lobe; Psychophysics; Somatosensory Cortex | 2009 |
Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia.
Topics: Administration, Oral; Adult; Alfentanil; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Humans; Hypercapnia; Isoxazoles; Male; Naloxone; Narcotic Antagonists; Oxygen; Pain; Respiratory Insufficiency; Young Adult | 2010 |
Effect of parecoxib pretreatment and venous occlusion on propofol injection pain: a prospective, randomized, double-blinded, placebo-controlled study.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Injections, Intravenous; Isoxazoles; Male; Middle Aged; Pain; Pain Measurement; Propofol; Prospective Studies; Tourniquets; Treatment Outcome; Young Adult | 2010 |
A randomized, placebo-controlled study to assess the efficacy and safety of 3 doses of paliperidone palmitate in adults with acutely exacerbated schizophrenia.
Topics: Acute Disease; Adult; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Isoxazoles; Male; Pain; Paliperidone Palmitate; Palmitates; Schizophrenia; Treatment Outcome; Young Adult | 2010 |
Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans.
Topics: Adult; Analgesics, Opioid; Blood Pressure; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Interactions; Humans; Hyperalgesia; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Remifentanil; Time Factors; Young Adult | 2011 |
Prevention of pain on injection of rocuronium: a comparison of lidocaine with different doses of parecoxib.
Topics: Academic Medical Centers; Adult; Androstanols; Anesthetics, Local; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections; Isoxazoles; Lidocaine; Male; Middle Aged; Neuromuscular Nondepolarizing Agents; Pain; Pain Measurement; Prospective Studies; Rocuronium; Severity of Illness Index | 2012 |
Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human.
Topics: Acute Disease; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antipruritics; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Feces; Glucuronidase; Humans; Isoenzymes; Isoxazoles; Male; Mass Spectrometry; Membrane Proteins; Pain; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 2002 |
An index of the three core data set patient questionnaire measures distinguishes efficacy of active treatment from that of placebo as effectively as the American College of Rheumatology 20% response criteria (ACR20) or the Disease Activity Score (DAS) in
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Health Status; Humans; Isoxazoles; Joints; Leflunomide; Methotrexate; Pain; Pain Measurement; Placebos; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2003 |
A comparison of the upper gastrointestinal mucosal effects of valdecoxib, naproxen and placebo in healthy elderly subjects.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Gastrointestinal Diseases; Humans; Intestinal Mucosa; Isoxazoles; Naproxen; Osteoarthritis; Pain; Risk Factors; Sulfonamides | 2003 |
Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects.
Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Humans; Isoxazoles; Ketorolac; Male; Middle Aged; Pain; Treatment Outcome | 2004 |
Therapeutic interchange involving replacement of rofecoxib or celecoxib with valdecoxib.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Celecoxib; Chronic Disease; Cost Savings; Cyclooxygenase 2; Drug Utilization Review; Endpoint Determination; Female; Hospitals, Veterans; Humans; Isoenzymes; Isoxazoles; Lactones; Male; Membrane Proteins; Osteoarthritis; Pain; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Therapeutic Equivalency | 2004 |
Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Combinations; Emergency Medicine; Female; Humans; Isoxazoles; Male; Musculoskeletal Diseases; Oxycodone; Pain; Pain Measurement; Prospective Studies; Sulfonamides; Treatment Outcome | 2004 |
Constitutive cyclooxygenase-2 is involved in central nociceptive processes in humans.
Topics: Adult; Cross-Over Studies; Cyclooxygenase 2; Double-Blind Method; Female; Humans; Isoxazoles; Male; Pain; Pain Threshold; Reflex; Spinal Cord | 2007 |
Utility and sensitivity of the sore throat pain model: results of a randomized controlled trial on the COX-2 selective inhibitor valdecoxib.
Topics: Adolescent; Adult; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Humans; Isoxazoles; Male; Middle Aged; Models, Biological; Pain; Pain Measurement; Pharyngitis; Sensitivity and Specificity; Sulfonamides | 2007 |
Analgesia during extracorporeal shockwave lithotripsy: fentanyl citrate versus parecoxib sodium.
Topics: Adult; Aged; Analgesics, Opioid; Cyclooxygenase Inhibitors; Female; Fentanyl; Humans; Isoxazoles; Lithotripsy; Male; Middle Aged; Pain | 2008 |
51 other study(ies) available for isoxazoles and Ache
| Article | Year |
|---|---|
Nano-Carbon-Based Application of Parecoxib Sodium Combined with Hydromorphone in Preventing Anesthesia Hyperalgesia Caused by Remifentanil after Thyroidectomy.
Topics: Analgesics, Opioid; Anesthesia; Humans; Hydromorphone; Hyperalgesia; Isoxazoles; Pain; Piperidines; Remifentanil; Thyroidectomy | 2022 |
Investigation of antioxidant and anti-nociceptive potential of isoxazolone, pyrazolone derivatives, and their molecular docking studies.
Topics: Analgesics; Animals; Antioxidants; Biphenyl Compounds; Isoxazoles; Mice; Molecular Docking Simulation; Pain; Picrates; Pyrazolones | 2020 |
A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain.
Topics: Animals; Benzophenones; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Interleukin-1beta; Intervertebral Disc Degeneration; Isoxazoles; Mice, Inbred C57BL; Molecular Targeted Therapy; Nucleus Pulposus; Pain; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Transcription Factor AP-1 | 2017 |
Enhanced Activities of δ Subunit-containing GABA
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; GABA-A Receptor Agonists; Isoxazoles; Long-Term Potentiation; Male; Nerve Fibers, Unmyelinated; Pain; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Spinal Cord; Synapses | 2018 |
Drug analogs of COX-2 selective inhibitors lumiracoxib and valdecoxib derived from in silico search and optimization.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Computer Simulation; Cyclooxygenase 2 Inhibitors; Diclofenac; Drug Design; Humans; Isoxazoles; Models, Molecular; Neoplasms; Pain; Sulfonamides | 2014 |
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties.
Topics: Amidohydrolases; Analgesics; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Isoxazoles; Kinetics; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; Pain; Pain Measurement; Piperidines; Structure-Activity Relationship; Thiazoles | 2016 |
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intraperitoneal; Isoxazoles; Ligands; Mice; Mice, Inbred Strains; Molecular Structure; Pain; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship | 2016 |
A Novel Approach for the Control of Inflammatory Pain: Prostaglandin E2 Complexation by Randomly Methylated β-Cyclodextrins.
Topics: Animals; beta-Cyclodextrins; Computer Simulation; Cyclooxygenase 2 Inhibitors; Dinoprostone; Electrophoresis, Capillary; Hyperalgesia; Inflammation; Inflammation Mediators; Isoxazoles; Male; Methylation; Pain; Pain Measurement; Pain Threshold; Postural Balance; Rats; Rats, Wistar | 2017 |
[Clinical characteristics of 4 cases of scleritis associated with systemic lupus erythematosus].
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Arthritis; Cyclophosphamide; Disease Progression; Female; Hematologic Diseases; Humans; Isoxazoles; Leflunomide; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Middle Aged; Pain; Prognosis; Raynaud Disease; Recurrence; Scleritis; Serositis; Treatment Outcome; Triamcinolone Acetonide; Uveitis; Vision Disorders | 2016 |
Rationally designed benzopyran fused isoxazolidines and derived β
Topics: Amino Alcohols; Analgesics; Animals; Benzopyrans; Cell Line; Chemistry Techniques, Synthetic; Drug Design; Female; Humans; Isoxazoles; Male; Mice; Molecular Docking Simulation; Pain; Prostaglandin-Endoperoxide Synthases; Protein Conformation; Receptors, Opioid | 2017 |
Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Formaldehyde; Inflammation; Isoxazoles; Male; Mice; Pain; Streptozocin; Zonisamide | 2008 |
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
Topics: Animals; Isoxazoles; Models, Molecular; Molecular Structure; Pain; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Spinal Nerves; Structure-Activity Relationship | 2009 |
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
Topics: Animals; Cell Line; Chronic Disease; Humans; Isoxazoles; Pain; Rats; Sodium Channel Blockers; Sodium Channels; Spinal Nerves; Structure-Activity Relationship | 2009 |
Effects of Parecoxib and Fentanyl on nociception-induced cortical activity.
Topics: Action Potentials; Analgesics, Opioid; Animals; Arousal; Cerebral Cortex; Cyclooxygenase 2 Inhibitors; Electroencephalography; Electrophysiology; Evoked Potentials; Fentanyl; Gyrus Cinguli; Heart Rate; Isoxazoles; Neurons; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Respiration; Somatosensory Cortex | 2010 |
A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.
Topics: Animals; Benzoic Acid; D-Amino-Acid Oxidase; Enzyme Inhibitors; Formaldehyde; Isoxazoles; Male; Pain; Pain Measurement; Rats; Rats, Wistar | 2011 |
Identification of potent, soluble, and orally active TRPV1 antagonists.
Topics: Administration, Oral; Amides; Animals; Disease Models, Animal; Humans; Isoxazoles; Pain; Rats; TRPV Cation Channels | 2011 |
Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship.
Topics: Administration, Oral; Animals; Carbamates; Humans; Infusion Pumps; Inhibitory Concentration 50; Isoxazoles; Molecular Structure; Pain; Rats; Sodium Channel Blockers; Structure-Activity Relationship | 2011 |
D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.
Topics: Analgesics; Animals; Behavior, Animal; D-Amino-Acid Oxidase; Formaldehyde; Hydrogen Peroxide; Hyperalgesia; Isoxazoles; Male; Mice; Pain; Rats; Rats, Wistar; Serine; Spine | 2012 |
Interactions of the potent D-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia.
Topics: Analgesics, Opioid; Animals; D-Amino-Acid Oxidase; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Injections, Spinal; Injections, Subcutaneous; Isoxazoles; Male; Mice; Morphine; N-Methylaspartate; Pain; Pain Measurement; Reaction Time; Receptors, N-Methyl-D-Aspartate | 2012 |
Contributions of spinal D-amino acid oxidase to bone cancer pain.
Topics: Analgesia; Analgesics, Opioid; Animals; Astrocytes; Bone Neoplasms; Carcinoma 256, Walker; D-Amino-Acid Oxidase; Enzyme Inhibitors; Female; Gene Expression; Hyperalgesia; Injections, Spinal; Isoxazoles; Morphine; Nerve Tissue Proteins; Pain; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Opioid, mu; Spinal Cord; Tibia | 2012 |
The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Butadienes; Cholinergic Agents; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Injections, Spinal; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Motor Activity; Nitriles; Pain; Pain Measurement; Phenylurea Compounds; Physical Stimulation; Postural Balance; Reaction Time; Receptors, Nicotinic | 2013 |
[Rapid and safe pain management. Promising new cyclooxygenase inhibitor].
Topics: Clinical Trials as Topic; Cyclooxygenase Inhibitors; Delayed-Action Preparations; Humans; Isoxazoles; Pain; Sulfonamides | 2002 |
Concluding remarks. C0X-2-selective inhibition: a new advance in pain management.
Topics: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain; Premedication; Prostaglandin-Endoperoxide Synthases | 2002 |
[Adverse effect-free analgesia. New COX-2 inhibitor is even more selective].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Isoxazoles; Membrane Proteins; Pain; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Treatment Outcome | 2003 |
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Density; Bone Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Isoenzymes; Isoxazoles; Organic Chemicals; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Radiology; Rats; Rats, Sprague-Dawley; Sulfonamides; Time Factors; Tumor Cells, Cultured | 2004 |
Weekly leflunomide as monotherapy for recent-onset rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Isoxazoles; Joints; Leflunomide; Male; Outpatients; Pain; Treatment Outcome | 2004 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Endotoxins; Female; Fever; Formaldehyde; Hindlimb; Hyperalgesia; Injections, Intravenous; Isoenzymes; Isoxazoles; Ketorolac; Male; Mice; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach | 2004 |
Successful use of zonisamide for central poststroke pain.
Topics: Anticonvulsants; Calcium Channel Blockers; Calcium Channels, T-Type; Cerebral Infarction; Diabetes Complications; gamma-Aminobutyric Acid; Humans; Isoxazoles; Magnetic Resonance Imaging; Male; Middle Aged; Pain; Stroke; Zonisamide | 2004 |
Utilization of zonisamide in patients with chronic pain or epilepsy refractory to other treatments: a retrospective, open label, uncontrolled study in a VA hospital.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Chronic Disease; Epilepsy; Humans; Isoxazoles; Male; Middle Aged; Pain; Retrospective Studies; Treatment Outcome; Zonisamide | 2004 |
[Review of analgesics].
Topics: Analgesics; Delayed-Action Preparations; Drug and Narcotic Control; Drug Prescriptions; Drug Therapy; France; Humans; Isoxazoles; Oxycodone; Pain; Patient Selection; Tramadol | 2004 |
Another popular painkiller gets the government's hook.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug and Narcotic Control; Drug Labeling; Humans; Isoxazoles; Pain; Sulfonamides; United States; United States Food and Drug Administration | 2005 |
Parecoxib: renal failure.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Australia; Humans; Isoxazoles; Middle Aged; Pain; Renal Insufficiency | 2005 |
Pfizer withdraws Bextra in South Africa.
Topics: Cyclooxygenase Inhibitors; Drug Industry; Humans; Isoxazoles; Pain; South Africa; Sulfonamides | 2005 |
Valdecoxib withdrawal leaves pain relief treatment gap.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Decision Making; Drug Industry; Humans; Isoxazoles; Pain; Public Policy; Risk Factors; Sulfonamides; United States; United States Food and Drug Administration | 2005 |
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
Topics: Animals; Antioxidants; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Isoxazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Sciatic Nerve; Time Factors; Touch; Zonisamide | 2005 |
Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cattle; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Humans; Hyperalgesia; Inflammation; Isoxazoles; Male; Models, Molecular; Molecular Structure; Pain; Pain Measurement; Rabbits; Rats; Rats, Wistar; Recombinant Proteins; Stereoisomerism; Sulfonamides; Time Factors | 2008 |
GABAergic mechanisms in antinociception.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Analgesics; Animals; Baclofen; Bicuculline; Central Nervous System; gamma-Aminobutyric Acid; Isoxazoles; Mice; Muscimol; Pain; Rats; Stereoisomerism; Substance P; Synaptic Transmission; Vigabatrin | 1984 |
The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. A phase-1-2 study.
Topics: Adult; Aged; Analgesics; Analysis of Variance; Chronic Disease; Drug Evaluation; Female; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Oxazoles; Pain | 1983 |
Analgesic, respiratory and endocrine responses in normal man to THIP, a GABA-agonist.
Topics: Adult; Analgesics; Dental Pulp Test; Double-Blind Method; Hormones; Humans; Hydrocortisone; Isoxazoles; Male; Oxazoles; Pain; Prolactin; Random Allocation; Respiration; Sensory Thresholds | 1983 |
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications.
Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Motor Activity; Muscimol; Pain; Phencyclidine; Reflex | 1980 |
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Dimethylphenylpiperazinium Iodide; Ganglia, Spinal; Hybrid Cells; Isoxazoles; Mice; Neuroblastoma; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Rubidium; Substance P; Synaptic Transmission | 1997 |
Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Pain; Peritoneal Cavity; Prostaglandin-Endoperoxide Synthases; RNA, Messenger | 1998 |
Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cyclooxygenase 1; Cyclooxygenase 2; Female; Isoenzymes; Isoxazoles; Membrane Proteins; Mice; Mice, Inbred Strains; Pain; Prostaglandin-Endoperoxide Synthases; Time Factors | 1998 |
Interactions between antinociception induced by cholecystokinin antagonists and GABA agonists in the tail-flick test.
Topics: Animals; Baclofen; Benzodiazepinones; Devazepide; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; Isoxazoles; Male; Mice; Motor Activity; Pain; Pain Measurement; Phenylurea Compounds; Proglumide; Receptors, Cholecystokinin; Tail | 1998 |
Effects of CCK antagonists on GABA mechanism-induced antinociception in the formalin test.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Baclofen; Dose-Response Relationship, Drug; Formaldehyde; GABA Agents; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Morphine; Pain; Pain Measurement; Receptors, Cholecystokinin | 1999 |
Parecoxib (parecoxib sodium).
Topics: Abdominal Pain; Cyclooxygenase Inhibitors; Dizziness; Headache; Humans; Infusions, Intravenous; Injections, Intramuscular; Isoxazoles; Nausea; Pain; Randomized Controlled Trials as Topic | 2001 |
The injectable cyclooxygenase-2-specific inhibitor parecoxib sodium has analgesic efficacy when administered preoperatively.
Topics: Adolescent; Adult; Analgesics; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Female; Humans; Injections, Intravenous; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Molar, Third; Oral Surgical Procedures; Pain; Pain Measurement; Pain, Postoperative; Preoperative Care; Prostaglandin-Endoperoxide Synthases; Tooth Extraction | 2001 |
The parafasciculus thalami as a site for mediating the antinociceptive response to GABAergic drugs.
Topics: Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Opioid; Synaptic Transmission; Thalamic Nuclei | 1986 |
The GABA agonist THIP, attenuates antinociception in the mouse by modifying central cholinergic transmission.
Topics: Afferent Pathways; Analgesics; Animals; Central Nervous System; Cholinergic Fibers; GABA Antagonists; Isoxazoles; Male; Mice; Oxazoles; Pain; Physostigmine; Synaptic Transmission | 1987 |
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds | 1988 |
An antinociceptive profile of kojic amine: an analogue of gamma-aminobutyric acid (GABA).
Topics: Animals; Atropine; Atropine Derivatives; Baclofen; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Motor Activity; Pain; Pyrans; Pyrones | 1987 |