inp-0341 and Keratitis
inp-0341 has been researched along with Keratitis* in 1 studies
Other Studies
1 other study(ies) available for inp-0341 and Keratitis
Article | Year |
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Attenuation of
is an opportunistic pathogen and a major cause of corneal infections worldwide. The bacterium secretes several toxins through its type III secretion system (T3SS) to subvert host immune responses. In addition, it is armed with intrinsic as well as acquired antibiotic resistance mechanisms that make treatment a significant challenge and new therapeutic interventions are needed. Type III secretion inhibitors have been studied as an alternative or in accompaniment to traditional antibiotics to inhibit virulence of bacteria. In this study, INP0341, a T3SS inhibitor, inhibited cytotoxicity by Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Cell Line; Cornea; Disease Models, Animal; Epithelial Cells; Humans; Hydrazines; Keratitis; Mice; Mice, Inbred C57BL; Pseudomonas aeruginosa; Pseudomonas Infections; Type III Secretion Systems; Virulence | 2020 |