ibuprofen has been researched along with Ache in 479 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this prospective, double-blind, randomized controlled trial was to compare the effect of oral premedication of meloxicam, ketorolac, dexamethasone, ibuprofen, or placebo on the success of inferior alveolar nerve blocks (IANB) of mandibular posterior teeth in patients experiencing symptomatic irreversible pulpitis." | 9.69 | Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial. ( Elnaghy, AM; Elsaka, SE; Elshazli, AH, 2023) |
| "Our aim was to evaluate pain reduction provided by intranasal fentanyl (INF) compared with placebo in addition to ibuprofen." | 9.69 | Additive Value of Intranasal Fentanyl on Ibuprofen for Pain Management of Children With Moderate to Severe Headaches: A Randomized Controlled Trial. ( Bailey, B; Boutin, A; Gouin, S; Gravel, J; Lebel, D, 2023) |
| "This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM." | 9.51 | The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022) |
| "Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM." | 9.41 | Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023) |
| "The goal of this study was to compare the effects of ibuprofen and low-level laser therapy in alleviating orthodontic pain observed after elastomeric separator placement (ESP) by means of the analysis of interleukin 1‑beta (IL-1β) and substance P (SP) levels in gingival crevicular fluid (GCF) and visual analog scale (VAS)." | 9.41 | Effects of ibuprofen and low-level laser therapy on orthodontic pain by means of the analysis of interleukin 1-beta and substance P levels in the gingival crevicular fluid. ( Alkan, Ö; Kaya, Y; Keskin, S; Kömüroglu, AU, 2021) |
| "To determine individual responses to ibuprofen gel or capsaicin cream for painful, radiographic knee OA using a series of n-of-1 trials." | 9.41 | Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials. ( Doherty, M; Fernandes, G; Persson, MSM; Sarmanova, A; Stocks, J; Walsh, DA; Zhang, W, 2021) |
| "We did not find any statistically significant difference among CYP2C9 phenotypes related to ibuprofen response, although CYP2C9 poor metabolizers had a longer effect (higher pain relief at 6 hours)." | 9.41 | Influence of Genetic Polymorphisms on the Response to Tramadol, Ibuprofen, and the Combination in Patients With Moderate to Severe Pain After Dental Surgery. ( Abad-Santos, F; Acero, J; Borobia, AM; Burgueño, M; Cabaleiro, T; Carcas, AJ; Gálvez-Múgica, MÁ; Llanos, L; Martínez-Pérez, D; Muñoz-Guerra, MF; Ochoa, D; Puerro, M; Saiz-Rodríguez, M; Valdez-Acosta, S, 2021) |
| "This study aimed to investigate the effectiveness of using bite wafers and chewing gum in relieving pain after the activation of the first archwire among Saudi orthodontic patients and evaluating them in comparison with ibuprofen use." | 9.34 | Comparative Assessment between Ibuprofen, Chewing Gum, and Bite Wafers in Pain Control Following First Archwire Placement in Orthodontic Patients. ( Al Shayea, EI, 2020) |
| "The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial." | 9.34 | Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020) |
| "To evaluate the effectiveness of verbal behavior modification, acetaminophen, and the combined effectiveness of verbal behavior modification along with acetaminophen on orthodontic pain." | 9.30 | A randomized, single-blind, placebo-controlled trial to evaluate the effectiveness of verbal behavior modification and acetaminophen on orthodontic pain. ( Abraham, R; Bansal, N; Kaur, H, 2019) |
| "There was no difference in analgesic effects or side effects observed using oral paracetamol, ibuprofen or a combination of both in patients with mild to moderate pain after soft tissue injuries attending the ED." | 9.27 | Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial. ( Cattermole, GN; Graham, CA; Hung, KKC; Leung, LY; Leung, YK; Lo, RSL; Man, SY; Rainer, TH; Woo, WK, 2018) |
| "The first-line use of ibuprofen rather than acetaminophen for postpartum pain did not lengthen the duration of severe-range hypertension in women with preeclampsia with severe features." | 9.27 | Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. ( Blue, NR; Drake-Lavelle, S; Holbrook, BD; Katukuri, VR; Leeman, L; Mozurkewich, EL; Murray-Krezan, C; Weinberg, D, 2018) |
| " One arm was given sugar-free chewing gum and the other arm ibuprofen for pain relief." | 9.24 | Chewing gum vs. ibuprofen in the management of orthodontic pain, a multi-centre randomised controlled trial - the effect of anxiety. ( Atack, NE; Bradley, R; Deacon, S; Ellis, P; Ewings, P; Griffiths, H; House, K; Ireland, AJ; Jordan, A; Moore, MB; Sandy, JR; Scaysbrook, E; Wenger, N; Williams, JC; Worth, V, 2017) |
| "The aim of this randomized clinical study was to investigate the effectiveness of acetaminophen 650 mg or liquefied ibuprofen 400 mg in pain control of orthodontic patients during separation with an elastic separator." | 9.22 | Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial. ( Ghadirian, H; Hosseinzadeh Nik, T; Ostad, SN; Shahsavari, N, 2016) |
| "Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking." | 9.22 | Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016) |
| "Although liposomal bupivacaine had some effect on soft tissue anesthesia, it did not reduce pain to manageable clinical levels in patients presenting with untreated, symptomatic irreversible pulpitis." | 9.22 | Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial. ( Beck, M; Bultema, K; Drum, M; Fowler, S; Nusstein, J; Reader, A, 2016) |
| "To evaluate if ibuprofen 800mg reduces pain with intrauterine device (IUD) insertion among U." | 9.20 | Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial. ( Bednarek, PH; Creinin, MD; Cwiak, C; Espey, E; Jensen, JT; Reeves, MF, 2015) |
| "This study aims to evaluate and compare the effect of pre-procedural administration of acetaminophen, ibuprofen, and meloxicam in reducing pain after separator placement." | 9.20 | Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial. ( Babanouri, N; Oshagh, M; Salehi, P; Torkan, S; Zarif Najafi, H, 2015) |
| " Our objective was to determine whether morphine administered orally has superior efficacy to ibuprofen in fracture-related pain." | 9.19 | Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial. ( Ali, S; Bale, M; Bhullar, G; Howard, J; Langford, C; Lim, R; Lin, K; Mainprize, D; Papini, A; Poonai, N; Rieder, MJ; Stitt, L; Teefy, J, 2014) |
| "To compare the efficacy of a combination of codeine with ibuprofen to ibuprofen alone on the intensity of pain experienced by children presenting to the ED with a musculoskeletal trauma to a limb." | 9.17 | Efficacy of an ibuprofen/codeine combination for pain management in children presenting to the emergency department with a limb injury: a pilot study. ( Fortin, C; Gouin, S; Julien, M; Le May, S; Messier, A; Robert, MA, 2013) |
| "Pre-emptive ibuprofen treatment was found to be more effective than a placebo in pain prevention, as determined by a significantly lower need for additional analgesia: 11 of 29 (38%) vs." | 9.16 | Pre-emptive effect of ibuprofen versus placebo on pain relief and success rates of medical abortion: a double-blind, randomized, controlled study. ( Avraham, S; Duvdevani, NR; Frenkel, Y; Gat, I; Haas, J; Seidman, DS, 2012) |
| "Dalteparin is superior to the NSAID ibuprofen in preventing extension of superficial thrombophlebitis during the 14-day treatment period with similar relief of pain and no increase in bleeding." | 9.16 | A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis. ( Aston, CE; Rathbun, SW; Whitsett, TL, 2012) |
| "Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis." | 9.15 | A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. ( Aspley, S; Doherty, M; Gibb, I; Goulder, M; Hawkey, C; Hill, N; Reader, S, 2011) |
| "To investigate the effect of 12 weeks of strength training in combination with a nonsteroidal anti-inflammatory drug (NSAID), glucosamine, or placebo on muscle cross-sectional area (CSA), strength (primary outcome parameters), and function, power, pain, and satellite cell number (secondary outcome parameters) in patients with knee osteoarthritis (OA)." | 9.15 | Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients. ( Aagaard, P; Beyer, N; Hansen, M; Holm, L; Kjaer, M; Mackey, AL; Petersen, SG, 2011) |
| "In patients experiencing acute visceral pain as a result of primary dysmenorrhea, dexibuprofen was associated with a dose-dependent effective analgesia; this effect was at least equivalent to that of the double dose of ibuprofen." | 9.14 | ADIDAC trial: analgesia with dexibuprofen versus ibuprofen in patients suffering from primary dysmenorrhea: a crossover trial. ( Kaehler, ST; Kollenz, C; Phleps, W, 2009) |
| "This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting." | 9.14 | Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial. ( Friday, JH; Harley, JR; Kanegaye, JT; McCaslin, I; Zheng, A, 2009) |
| "We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)." | 9.14 | A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. ( Brousseau, DC; Drendel, AL; Gorelick, MH; Kim, MK; Lyon, R; Weisman, SJ, 2009) |
| "Group A, receiving ibuprofen before and after separator placement, experienced significantly less pain (P <0." | 9.14 | Effects of preoperative ibuprofen on pain after separator placement. ( Fillingim, R; Logan, H; Marris, CK; McGorray, SP; Minor, V; Wheeler, TT; Yezierski, R, 2009) |
| "In a randomized double-blinded clinical trial, 150 patients (50 per group) with irreversible pulpitis were given placebo, 600 mg ibuprofen, or 75 mg indomethacin 1 hour before local anesthesia." | 9.14 | The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis. ( Abbott, PV; Ashouri, R; Askarifard, S; Nakhaee, N; Pardakhti, A; Parirokh, M; Rekabi, AR, 2010) |
| " They were randomized to receive ibuprofen or paracetamol when pain relief was necessary." | 9.14 | Ibuprofen and paracetamol for pain relief during medical abortion: a double-blind randomized controlled study. ( David, LB; Livshits, A; Machtinger, R; Moshe-Zahav, A; Seidman, DS; Spira, M, 2009) |
| "To test the efficacy of ibuprofen in reducing needle electromyography (EMG) pain we studied 30 healthy volunteers randomized to receive placebo or ibuprofen (400 mg) 2 h before EMG using concentric needle electrodes in four muscles." | 9.13 | Prospective double-blind crossover trial of ibuprofen in reducing EMG pain. ( El-Salem, K; Shakhatreh, M, 2008) |
| "To compare an ibuprofen-releasing foam dressing (Biatain Ibu, ColoplastA/S) with local best practice in the treatment of painful exuding wounds." | 9.13 | Effect of an ibuprofen-releasing foam dressing on wound pain: a real-life RCT. ( Altindas, M; Johannesen, N; Jortikka, A; Orsted, H; Palao i Domenech, R; Persson, LM; Ram, A; Romanelli, M; Schäfer, E; Slonková, V; Tsiftsis, DD, 2008) |
| "The study was conducted to determine whether tramadol is more effective than ibuprofen for reducing pain during uterine aspiration for abortion." | 9.13 | A randomized trial of tramadol versus ibuprofen as an adjunct to pain control during vacuum aspiration abortion. ( Gilliam, M; Romero, I; Turok, D, 2008) |
| "Cobrotoxin produces intense analgesia but it has an onset of response of 1-3 h which hampers its clinical use in cancer pain." | 9.12 | Cobrotoxin-containing analgesic compound to treat chronic moderate to severe cancer pain: results from a randomized, double-blind, cross-over study and from an open-label study. ( Bruno, M; Feng, FY; Huang, FL; Paradiso, A; Song, ST; Xie, GR; Xu, JM; Xu, LG; Yang, Y; Zhang, CZ, 2006) |
| "This study was undertaken to determine whether 400 mg of prophylactic ibuprofen can alleviate pain from insertion of an intrauterine device (IUD) and to measure level of pain with improved techniques." | 9.12 | Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen. ( Chen, PL; Croxatto, H; Hubacher, D; Lillo, S; Reyes, V; Zepeda, A, 2006) |
| "Our goal was to determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries." | 9.12 | A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. ( Clark, E; Correll, R; Gaboury, I; Passi, B; Plint, AC, 2007) |
| "The aim of the study was to evaluate a novel foam dressing with continuous low-level release of ibuprofen (Biatain-Ibu foam dressing, Coloplast A/S, Humlebaek, Denmark) in persons with leg ulcers compared to local best practice." | 9.12 | A pilot (real-life) randomised clinical evaluation of a pain-relieving foam dressing: (ibuprofen-foam versus local best practice). ( Coutts, P; Fierheller, M; Sibbald, RG; Woo, K, 2007) |
| "To compare efficacy of pain syndrome relief in osteoarthrosis at conventional administration and ultraphonophoresis of ibuprofen (nurofen gel), we applied ultraphonophoresis of 5% gel nurofen to affected joints of 20 patients of the study group (twice a day with a 5-6 hour interval; the third time the gel was applied locally in the evening)." | 9.12 | [Efficacy of ibuprofen (nurofen gel) ultraphonophoresis for pain relief in osteoarthrosis]. ( Serikov, NP, 2007) |
| "This prospective, randomized, double-blinded, clinical trial compared the effectiveness of oxycodone, ibuprofen, and the combination in children (age, 6-18 years), with pain from a suspected orthopedic injury." | 9.12 | Effectiveness of oxycodone, ibuprofen, or the combination in the initial management of orthopedic injury-related pain in children. ( Godambe, SA; Koller, DM; Lorenz, D; Myers, AB, 2007) |
| "This study will provide new evidence on the overall costs and benefits of treating chronic knee pain with either oral or topical ibuprofen." | 9.11 | TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care: a randomised controlled trial with patient preference study. [ISRCTN79353052]. ( Ashby, D; Cross, PL; Harding, G; Hennessy, EM; Letley, L; Parsons, S; Spencer, AE; Underwood, M, 2005) |
| "The goal of this study was to compare the efficacy and safety of OTC doses of naproxen (400 mg) and naproxen/naproxen sodium (200/220 mg) with acetaminophen (1000 mg), ibuprofen (200 mg), and placebo in the treatment of primary dysmenorrhea." | 9.10 | Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. ( Akin, MD; Dawood, MY; Milsom, I; Minic, M; Niland, NF; Spann, J; Squire, RA, 2002) |
| "2 g daily), aspirin and paracetamol (both up to 3 g daily) for up to seven days, in patients with mild to moderate pain resulting from cold/flu symptoms or sore throat (CF/ST) (n = 2,815)." | 9.10 | Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. ( Cairns, R; Le Parc, JM; Moore, N; Schneid, H; van Ganse, E; Wall, R, 2002) |
| "Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor used to treat pain." | 9.10 | A randomized, clinical trial comparing oral celecoxib 200 mg, celecoxib 400 mg, and ibuprofen 600 mg for acute pain. ( Goldberg, J; Kenwood, A; Lavery, R; Salo, DF; Shapiro, T; Varma, V, 2003) |
| "Pretreatment with ibuprofen before major hip surgery does not improve the pain scores or reduce morphine requirement but significantly increases blood loss." | 9.10 | Prior ibuprofen exposure does not augment opioid drug potency or modify opioid requirements for pain inhibition in total hip surgery. ( Bugter, ML; Dirksen, R; Jhamandas, K; Milne, B; Slappendel, R; Weber, EW, 2003) |
| "Sore throat pain provided a sensitive model to assess the analgesic efficacy of class I analgesics and discriminated between the analgesic efficacy of ibuprofen and paracetamol." | 9.09 | Use of a simple pain model to evaluate analgesic activity of ibuprofen versus paracetamol. ( Bhagat, K; Lala, I; Leech, P; Montgomery, L, 2000) |
| " A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain." | 9.09 | Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model. ( Dallob, A; De Lepeleire, I; De Schepper, P; Ehrich, EW; Gertz, BJ; Mehlisch, DR; Porras, A; Riendeau, D; Seibold, JR; Van Hecken, A; Wittreich, J; Yuan, W, 1999) |
| "5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain." | 9.09 | Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain. ( Damask, MJ; de Padova, A; Doyle, RT; Jiang, JG; Landau, CJ; Morris, E; Palangio, M, 2000) |
| "None of the therapies-standard care (ice, elevation, immobilization), standard care with ibuprofen, or standard care with music distraction-provided clinically significant pain relief to patients who had minor musculoskeletal trauma (ie, sprains and fractures) and moderate pain at triage." | 9.09 | The effect of standard care, ibuprofen, and music on pain relief and patient satisfaction in adults with musculoskeletal trauma. ( Marcantonio, R; Paice, J; Spiller, M; Tanabe, P; Thomas, R, 2001) |
| "To determine whether greater pain intensity at initiation of treatment predicted better response to ibuprofen than to acetaminophen in subjects with knee osteoarthritis (OA)." | 9.09 | Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis. ( Bradley, JD; Brandt, KD; Katz, BP, 2001) |
| "To compare the treatment potential of glucosamine sulfate (GS) and ibuprofen in patients diagnosed with temporomandibular joint (TMJ) osteoarthritis (OA)." | 9.09 | Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. ( Major, PW; Prasad, NG; Thie, NM, 2001) |
| "Ibuprofen and acetaminophen with codeine had similar analgesic properties in the first 24 hours post partum (mean pain rating 3." | 9.09 | Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial. ( Douglas, MJ; Grange, CS; Janssen, PA; Peter, EA, 2001) |
| "To evaluate the efficacy of IM ketorolac versus that of oral ibuprofen in acute musculoskeletal pain." | 9.08 | Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995) |
| "Sixty female out-patients suffering from moderate to severe primary dysmenorrhea, aged 14-40 years (mean 27 years), entered this randomized, double-blind, 3-period, within-patient study, evaluating the efficacy and tolerability of diclofenac dispersible 46." | 9.08 | Comparative efficacy of diclofenac dispersible 50 mg and ibuprofen 400 mg in patients with primary dysmenorrhea. A randomized, double-blind, within-patient, placebo-controlled study. ( Bakshi, R; Fedele, L; Marchini, M; Pistai, R; Tozzi, L, 1995) |
| " ketorolac is superior to oral ibuprofen in patients presenting to an ED in moderate to severe pain." | 9.08 | Intramuscular ketorolac vs oral ibuprofen in emergency department patients with acute pain. ( Neighbor, ML; Puntillo, KA, 1998) |
| "We used electrically induced pain in healthy young subjects to study gender differences in nociception and the analgesic efficacy of ibuprofen." | 9.08 | Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen. ( Carmody, JJ; Walker, JS, 1998) |
| " The aim of this study was to investigate the dose-related effects of ibuprofen (placebo, 400 and 800 mg rac-ibuprofen [Aktren], administered orally) on experimentally-induced tonic and phasic pain." | 9.07 | Dose-related effects of ibuprofen on pain-related potentials. ( Geisslinger, G; Gruber, M; Hummel, C; Hummel, T; Kobal, G, 1994) |
| "To compare carbon dioxide and nitrous oxide pneumoperitoneum with respect to intraoperative and postoperative pain during laparoscopic sterilization under local anesthesia." | 9.07 | The effect of nitrous oxide and carbon dioxide pneumoperitoneum on operative and postoperative pain during laparoscopic sterilization under local anesthesia. ( Ling, FW; Lipscomb, GH; McCord, ML; Summitt, RL, 1994) |
| "In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day." | 9.07 | Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991) |
| " The analgesic efficacy of single oral doses (400 mg, 800 mg) of ibuprofen on argon laser-induced pain was studied in a double-blind, placebo controlled, three way cross-over comparison." | 9.06 | A double-blind, placebo controlled, cross-over comparison of the analgesic effect of ibuprofen 400 mg and 800 mg on laser-induced pain. ( Arendt-Nielsen, L; Bjerring, P; Nielsen, JC; Petterson, KJ, 1990) |
| "Thirty subjects with chronic moderate to severe pain who were receiving oxycodone/acetaminophen (oxy/APAP) for analgesia were initially evaluated for at least 7 days for oxy/APAP requirements for pain control." | 9.06 | The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain. ( Drew, J; Stambaugh, JE, 1988) |
| "Under double-blind, crossover conditions, 43 women with primary dysmenorrhea received ketoprofen, ibuprofen, and placebo during three consecutive menstrual cycles." | 9.06 | Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison. ( Mehlisch, DR, 1988) |
| "A randomized, single-blind crossover trial tested the effect of 1,000 mg of ibuprofen on jaw muscle pain induced by maximum voluntary teeth clenching (MVC)." | 9.06 | Effect of ibuprofen on isometric contractions and associated pain of the human masseter muscle. ( Christensen, LV, 1987) |
| "Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children." | 9.05 | Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis. ( Braithwaite, I; Dalziel, SR; McKinlay, CJD; Tan, E, 2020) |
| "43 patients with osteoarthritis of the knee and/or hip(s) were treated with suprofen 800 mg/day or ibuprofen 1,600 mg/day for 14 days." | 9.05 | Comparison of suprofen and ibuprofen in the treatment of pain secondary to osteoarthritis. ( Schuermans, Y, 1983) |
| "In a double-blind parallel group randomised study 191 patients with acute sprains and strains of ankle, hip, shoulder or knees were treated with either 400 mg sulindac or 1200 mg ibuprofen per day for 4 days; of these, 176 completed the trial." | 9.05 | Sulindac versus ibuprofen in sprains and strains. ( Currie, WJ; Fyvie, A; Hayes, TB; Janke, PG; Vandenburg, MJ, 1984) |
| "The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study." | 9.05 | Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea. ( Andersch, B; Milsom, I, 1984) |
| "An open, multi-centre study in general practice was carried out in 1842 patients presenting with non-serious painful conditions to assess the effectiveness and tolerance of ibuprofen." | 9.05 | A multi-centre general practice study evaluating the efficacy and tolerance of ibuprofen in common painful conditions. ( Benvenuti, C; Beretta, A; Longoni, A; Pickvance, NJ, 1984) |
| "A double-blind crossover study compared sodium meclofenamate (300 mg daily) and ibuprofen (900 mg daily) in thirty patients with osteoarthritis." | 9.05 | Short-term treatment of osteoarthritis: a comparison of sodium meclofenamate and ibuprofen. ( Accardo, S; Cimmino, MA; Cutolo, M; Samantà, E, 1982) |
| "The efficacy of ibuprofen and naproxen-sodium for the treatment of primary dysmenorrhea was evaluated in a double-blind cross-over study in 57 otherwise healthy women." | 9.05 | Ibuprofen and naproxen-sodium in the treatment of primary dysmenorrhea: a double-blind cross-over study. ( Andersch, B; Milsom, I, 1985) |
| "Benorylate and ibuprofen appear to be useful drugs for pain relief in rheumatoid arthritis but benorylate would appear to have a slightly better effect on the pain score and it improved the grip strength more than the moderate doses of ibuprofen." | 9.04 | Comparison of benorylate and ibuprofen in the treatment of established rheumatoid arthritis. ( Coomes, EN; Darlington, LG, 1975) |
| "In a double-blind, multiclinic study, 437 patients with osteoarthritis were treated sequentially with ibuprofen, 1,800 mg/day, and placebo, or with aspirin, 3,600 mg/day, and placebo." | 9.04 | Ibuprofen in osteoarthritis. ( Brooks, CD; Donaldson, MS; Giansiracusa, JE; Koonce, ML; Lefton, TE; Ruoff, GE, 1977) |
| "A randomized double-blind study in ambulatory patients with osteoarthritis of hip and/or knee was conducted, comparing the efficacy and safety of diflunisal 500 mg daily with ibuprofen 1200 mg daily, and a period of 8 weeks." | 9.04 | A comparative clinical trial of diflunisal and ibuprofen in the control of pain in osteoarthritis. ( Keet, JG, 1979) |
| "In a double-blind multiclinic trial, a new nonsteroidal anti-inflammatory agent (ibuprofen) was compared with an established therapeutic agent (phenylbutazone-alka) for the treatment of osteoarthritis." | 9.04 | Ibuprofen versus buffered phenylbutazone in the treatment of osteoarthritis: double-blind trial. ( Donovan, JF; Hearron, MS; Levi, L; Moxley, TE; Royer, GL, 1975) |
| "To systematically review high-quality randomized controlled trials (RCTs) and meta-analysis on the effectiveness of use of ibuprofen and low-level laser therapy (LLLT) for pain control during fixed orthodontic appliance therapy." | 8.95 | Ibuprofen and Low-level Laser Therapy for Pain Control during Fixed Orthodontic Therapy: A Systematic Review of Randomized Controlled Trials and Meta-analysis. ( Bagheri, F; Eslamipour, F; Motamedian, SR, 2017) |
| "Ibuprofen is used to prevent high altitude headache (HAH) but its efficacy remains controversial." | 8.95 | Efficacy of ibuprofen on prevention of high altitude headache: A systematic review and meta-analysis. ( Jia, Z; Lu, H; Wang, R; Xiong, J, 2017) |
| "Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM." | 8.93 | Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016) |
| " For many years, ketorolac was the only intravenous NSAID available in the US, but in 2009 intravenous ibuprofen was approved by the US FDA for the treatment of pain and fever in adults." | 8.88 | Pharmacokinetics of intravenous ibuprofen: implications of time of infusion in the treatment of pain and fever. ( Smith, HS; Voss, B, 2012) |
| "To analyse major sources of evidence-based information on the efficacy and gastrointestinal tolerability of aspirin, used short-term, in over-the-counter (OTC) doses, to relieve acute pain and cold symptoms, including associated feverishness." | 8.88 | Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold. ( McCarthy, DM, 2012) |
| "Acetylsalicylic acid (ASA [aspirin]) is a commonly used over-the-counter drug for the treatment of pain, fever, or colds, but data on the safety of this use are very limited." | 8.87 | Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials. ( Baron, JA; Brueckner, A; Lanas, A; McCarthy, D; Senn, S; Voelker, M, 2011) |
| "To summarize studies testing the efficacy and safety of single-dose acetaminophen and ibuprofen for treating children's pain or fever." | 8.82 | Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. ( Champion, GD; Goodenough, B; Perrott, DA; Piira, T, 2004) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 8.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| " Effect of ibuprofen on muscle, hematological and renal function, hydric balance, pain, and performance during intense long-distance running." | 7.96 | Effect of Ibuprofen on Muscle, Hematological and Renal Function, Hydric Balance, Pain, and Performance During Intense Long-Distance Running. ( Aidar, FJ; Barros, NA; Cercato, LM; Chilibeck, P; da Silva, DS; de Matos, DG; de Souza, RF; Ferreira, ARP; Oliveira, AS, 2020) |
| "Severe hyponatremia is rare when carbamazepine is used as monotherapy." | 7.88 | Walking hyponatremia syndrome of inappropriate antidiuretic hormone secretion secondary to carbamazepine use: a case report. ( Palacios Argueta, PJ; Pineda, A; Sánchez Rosenberg, GF, 2018) |
| " The aim of this study was to assess whether differences in dissolution rates would affect the onset, magnitude, and duration of the time course of ibuprofen-mediating pain relief." | 7.83 | Bridging the Gap Between In Vitro Dissolution and the Time Course of Ibuprofen-Mediating Pain Relief. ( Cristofoletti, R; Dressman, JB, 2016) |
| "Ibuprofen and acetaminophen are frequently alternated or simultaneously used to treat fever or pain in children, while the evidence for the safety of such a combination is lacking." | 7.80 | Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system. ( Jiang, P; Sun, H; Wu, J; Yue, Z, 2014) |
| "Children who have unresolved pain despite the use of either ibuprofen or acetaminophen should have their medication regimen reviewed to ensure they are receiving the medication at an adequate dose and interval." | 7.78 | Alternating acetaminophen and ibuprofen for pain in children. ( Goldman, RD; Smith, C, 2012) |
| "To examine if wound aetiology has an effect on the pain-relieving properties of an ibuprofen-releasing foam dressing, which was previously shown to reduce pain in wounds of various aetiologies, compared with local best practice (LBP)." | 7.77 | Analgesic efficacy of an ibuprofen-releasing foam dressing compared with local best practice for painful exuding wounds. ( Arapoglou, V; Dimakakos, EP; Gjødsbøl, K; Glynn, C; Katsenis, K; Petersen, B; Schäfer, E; Syrigos, KN; Tsoutos, D; Zakopoulou, N, 2011) |
| "Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients." | 7.75 | Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009) |
| ", synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats." | 7.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| " The present study was undertaken to assess markers of inflammation, arthritis and pain in rats with adjuvant arthritis undergoing treatment with ibuprofen cream (Dolgit cream) and placebo." | 7.72 | Quantitative assessment of markers of inflammation, arthritis and pain in rats with adjuvant arthritis following the treatment with ibuprofen cream and placebo. ( Istok, R; Rovenský, J; Stancíková, M; Svík, K, 2003) |
| "(1) This codeine-based syrup is indicated for the treatment of pain in children." | 7.70 | Codeine for child pain: new preparation. Helpful in some cases. ( , 1999) |
| "The effects of combined single oral treatments with non-steroidal anti-inflammatory drugs (NSAIDs) and the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dextromethorphan (DM) on arthritic pain were examined in a rat model of adjuvant-induced arthritis." | 7.69 | Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats. ( Caruso, FS; Frenk, H; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1996) |
| "We report a case of biopsy-proven acute tubulointerstitial nephritis associated with a second course of flurbiprofen, a nonsteroidal anti-inflammatory drug of the propionic acid class." | 7.68 | Flurbiprofen-associated acute tubulointerstitial nephritis. ( Kaufhold, J; McCabe, K; Wilkowski, M, 1991) |
| "A double-blind three-way crossover design in the treatment of dysmenorrhea comparing a propionic acid derivative (ibuprofen) and a fenamate (mefenamic acid) with a placebo showed that both ibuprofen and mefenamic acid are generally superior to placebo." | 7.66 | A double-blind comparison of a propionic acid derivative (ibuprofen) and a fenamate (mefenamic acid) in the treatment of dysmenorrhea. ( Roy, S, 1983) |
| "Pain is often cited as one of the worst features of medical abortion." | 6.82 | Two prophylactic medication approaches in addition to a pain control regimen for early medical abortion < 63 days' gestation with mifepristone and misoprostol: study protocol for a randomized, controlled trial. ( Dragoman, MV; Dung, DL; Grossman, D; Habib, N; Huong, NM; Kapp, N; Tamang, A, 2016) |
| "More subjects reached the strict time limit of 30 min (analysed by logistic regression and adjusted OR as a post-hoc analysis) under EA compared with most other experimental conditions." | 6.77 | The effect of electroacupuncture and tramadol on experimental tourniquet pain. ( Choi, KE; Dobos, G; Gabriel, T; Lüdtke, R; Michalsen, A; Musial, F; Rampp, T, 2012) |
| "Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment." | 6.73 | Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. ( Dionne, RA; Hamza, M; Ramsay, ES; Wahl, SM; Wang, XM; Wu, TX, 2007) |
| " Serial blood sample were collected for bioavailability studies." | 6.73 | Rapidly dissolving formulations for quick absorption during pain episodes: ibuprofen. ( Aghazadeh-Habashi, A; Jamali, F, 2008) |
| "Naproxen and ibuprofen were more effective than acetaminophen in minimizing physical side effects of IFN beta-1a." | 6.71 | A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis. ( Filipi, M; Healey, K; Leuschen, MP, 2004) |
| "Ibuprofen was also better tolerated than diclofenac sodium (100 mg/day), the latter being associated with gastrointestinal side effects in a significant proportion of patients." | 6.68 | Ibuprofen and diclofenac sodium in the treatment of osteoarthritis: a comparative trial of two once-daily sustained-release NSAID formulations. ( Baumgartner, H; Blum, W; Bruhin, A; Gallachi, G; Goldinger, G; Saxer, M; Schwarz, HA; Trost, H, 1996) |
| " The 30% increase in analgesic effect may be of clinical benefit, and this trial design, cross-over with multiple dosing in out-patients, may be a sensitive test for analgesics, potentially more predictive of side-effect problems than single-dose studies." | 6.66 | Codeine 20 mg increases pain relief from ibuprofen 400 mg after third molar surgery. A repeat-dosing comparison of ibuprofen and an ibuprofen-codeine combination. ( Carroll, D; Juniper, RP; McQuay, HJ; Moore, RA; Watts, PG, 1989) |
| "The pharmacological agents approved for treating pain in these patients are few, also considering the recent limitation for codeine in children younger than 12 years." | 6.61 | Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview. ( Barbagallo, M; Sacerdote, P, 2019) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 6.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| " It is generally well tolerated after single or multiple doses and short-term use is not expected to produce any of the serious adverse effects typically associated with the long-term use of opioids or NSAIDs." | 6.43 | Oxycodone/Ibuprofen combination tablet: a review of its use in the management of acute pain. ( Oldfield, V; Perry, CM, 2005) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 6.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| "These data do not support the hypothesis that occasional intake of a small dose of caffeine as part of pain medication imposes a health risk due to vital sign changes." | 5.69 | Lack of Evidence for Blood Pressure Effects of Caffeine Added to Ibuprofen. ( Lampert, A; Lange, R; Weiser, T, 2023) |
| "The aim of this prospective, double-blind, randomized controlled trial was to compare the effect of oral premedication of meloxicam, ketorolac, dexamethasone, ibuprofen, or placebo on the success of inferior alveolar nerve blocks (IANB) of mandibular posterior teeth in patients experiencing symptomatic irreversible pulpitis." | 5.69 | Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial. ( Elnaghy, AM; Elsaka, SE; Elshazli, AH, 2023) |
| "Our aim was to evaluate pain reduction provided by intranasal fentanyl (INF) compared with placebo in addition to ibuprofen." | 5.69 | Additive Value of Intranasal Fentanyl on Ibuprofen for Pain Management of Children With Moderate to Severe Headaches: A Randomized Controlled Trial. ( Bailey, B; Boutin, A; Gouin, S; Gravel, J; Lebel, D, 2023) |
| "We aimed to characterize the current pain experience of patients completing an evidence-based mifepristone-misoprostol medication abortion regimen using real-time pain scores." | 5.51 | The experience of pain in real-time during medication abortion. ( Davis, J; Fontanilla, T; Friedlander, EB; Horiuchi, W; Kaneshiro, B; Raidoo, S; Salcedo, J; Soon, R; Tschann, M, 2022) |
| "This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM." | 5.51 | The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022) |
| "Ibuprofen (15 mg/kg) was administered once a day." | 5.43 | Ibuprofen intake increases exercise time to exhaustion: A possible role for preventing exercise-induced fatigue. ( Bobinski, F; Bresciani, G; Della Pace, ID; Ferreira, J; Fighera, MR; Ineu, RP; Lima, FD; Pereira, ME; Rambo, LM; Ribeiro, LR; Rossato, MF; Royes, LF; Santos, AR; Silva, MA; Stamm, DN, 2016) |
| "Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM." | 5.41 | Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023) |
| "To investigate the feasibility, and perform a pilot study, of a randomised clinical trial, investigating whether children experience less pain, fear and/or distress when they receive oral ibuprofen vs placebo before a needle is inserted in a subcutaneously implanted intravenous port." | 5.41 | Ibuprofen in needle procedures in children with cancer-A feasibility and pilot study. ( Hedén, L; Kamsvåg, T; Ljungman, G; von Essen, L, 2021) |
| "The goal of this study was to compare the effects of ibuprofen and low-level laser therapy in alleviating orthodontic pain observed after elastomeric separator placement (ESP) by means of the analysis of interleukin 1‑beta (IL-1β) and substance P (SP) levels in gingival crevicular fluid (GCF) and visual analog scale (VAS)." | 5.41 | Effects of ibuprofen and low-level laser therapy on orthodontic pain by means of the analysis of interleukin 1-beta and substance P levels in the gingival crevicular fluid. ( Alkan, Ö; Kaya, Y; Keskin, S; Kömüroglu, AU, 2021) |
| "To compare the overnight maximum pain scores after osmotic dilator placement prior to a dilation and evacuation (D&E) procedure in participants assigned to a prescription for ibuprofen alone or to ibuprofen plus oxycodone." | 5.41 | Opioid prescription for pain after osmotic dilator placement in abortion care: A randomized controlled trial. ( McAllister, A; Nagendra, D; Roe, AH; Sammel, MD; Schreiber, CA; Schurr, D; Shorter, JM; Sonalkar, S, 2021) |
| "To determine individual responses to ibuprofen gel or capsaicin cream for painful, radiographic knee OA using a series of n-of-1 trials." | 5.41 | Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials. ( Doherty, M; Fernandes, G; Persson, MSM; Sarmanova, A; Stocks, J; Walsh, DA; Zhang, W, 2021) |
| "We did not find any statistically significant difference among CYP2C9 phenotypes related to ibuprofen response, although CYP2C9 poor metabolizers had a longer effect (higher pain relief at 6 hours)." | 5.41 | Influence of Genetic Polymorphisms on the Response to Tramadol, Ibuprofen, and the Combination in Patients With Moderate to Severe Pain After Dental Surgery. ( Abad-Santos, F; Acero, J; Borobia, AM; Burgueño, M; Cabaleiro, T; Carcas, AJ; Gálvez-Múgica, MÁ; Llanos, L; Martínez-Pérez, D; Muñoz-Guerra, MF; Ochoa, D; Puerro, M; Saiz-Rodríguez, M; Valdez-Acosta, S, 2021) |
| "Ibuprofen is a well established analgesic, anti-inflammatory and antipyretic NSAID." | 5.38 | Intravenous ibuprofen: in adults for pain and fever. ( Scott, LJ, 2012) |
| "To evaluate whether prophylactic dronabinol, a synthetic tetrahydrocannabinol, reduces pain during medical abortion." | 5.34 | Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial. ( Alton, K; Bayer, LL; Beardsworth, K; Bednarek, PH; Colwill, AC; Edelman, A; Garg, B; Jensen, JT, 2020) |
| "This study aimed to investigate the effectiveness of using bite wafers and chewing gum in relieving pain after the activation of the first archwire among Saudi orthodontic patients and evaluating them in comparison with ibuprofen use." | 5.34 | Comparative Assessment between Ibuprofen, Chewing Gum, and Bite Wafers in Pain Control Following First Archwire Placement in Orthodontic Patients. ( Al Shayea, EI, 2020) |
| "The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial." | 5.34 | Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020) |
| "He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated." | 5.34 | Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007) |
| "To evaluate the effectiveness of verbal behavior modification, acetaminophen, and the combined effectiveness of verbal behavior modification along with acetaminophen on orthodontic pain." | 5.30 | A randomized, single-blind, placebo-controlled trial to evaluate the effectiveness of verbal behavior modification and acetaminophen on orthodontic pain. ( Abraham, R; Bansal, N; Kaur, H, 2019) |
| "There was no difference in analgesic effects or side effects observed using oral paracetamol, ibuprofen or a combination of both in patients with mild to moderate pain after soft tissue injuries attending the ED." | 5.27 | Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial. ( Cattermole, GN; Graham, CA; Hung, KKC; Leung, LY; Leung, YK; Lo, RSL; Man, SY; Rainer, TH; Woo, WK, 2018) |
| "The first-line use of ibuprofen rather than acetaminophen for postpartum pain did not lengthen the duration of severe-range hypertension in women with preeclampsia with severe features." | 5.27 | Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. ( Blue, NR; Drake-Lavelle, S; Holbrook, BD; Katukuri, VR; Leeman, L; Mozurkewich, EL; Murray-Krezan, C; Weinberg, D, 2018) |
| "A 21-year-old woman with systemic lupus erythematosus (SLE) had meningismus, conjunctivitis, lymphadenopathy, and elevation of liver function values following ibuprofen therapy." | 5.26 | Tolmetin-induced aseptic meningitis. ( Barth, WF; Ruppert, GB, 1981) |
| "To investigate the efficacy and safety of a recently developed ibuprofen medicated plaster in the treatment of acute sports impact injuries/contusions." | 5.24 | Efficacy and safety assessment of acute sports-related traumatic soft tissue injuries using a new ibuprofen medicated plaster: results from a randomized controlled clinical trial. ( Bhatt, A; Connolly, MP; Giannetti, B; Predel, HG, 2017) |
| "An observational study nested within a randomised controlled trial comparing oral paracetamol, ibuprofen or a combination of the two in 884 community-derived people with chronic knee pain." | 5.24 | Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial. ( Doherty, M; Hussain, S; McWilliams, D; Papou, A; Zhang, W, 2017) |
| " One arm was given sugar-free chewing gum and the other arm ibuprofen for pain relief." | 5.24 | Chewing gum vs. ibuprofen in the management of orthodontic pain, a multi-centre randomised controlled trial - the effect of anxiety. ( Atack, NE; Bradley, R; Deacon, S; Ellis, P; Ewings, P; Griffiths, H; House, K; Ireland, AJ; Jordan, A; Moore, MB; Sandy, JR; Scaysbrook, E; Wenger, N; Williams, JC; Worth, V, 2017) |
| "Ibuprofen is included on websites and frequently referenced lists as medium risk for inducing hemolysis in children with glucose-6-phosphate dehydrogenase (G6PD) deficiency." | 5.22 | Safety of Ibuprofen in Children With G6PD Deficiency: A Systematic Review. ( Chandar, A; Isaacson, G; Pankey, AN, 2022) |
| " Only one study found evidence of an effect between interventions on pain score: a prophylactic dose of ibuprofen 1600 mg likely reduces the pain score when compared to a dose of paracetamol 2000 mg (mean difference (MD) 2." | 5.22 | Pain management for medical abortion before 14 weeks' gestation. ( Cameron, S; Morroni, C; Reynolds-Wright, JJ; Woldetsadik, MA, 2022) |
| " Only one study found evidence of an effect between interventions on pain score: a prophylactic dose of ibuprofen 1600mg likely reduces the pain score when compared to a dose of paracetamol 2000mg (MD 2." | 5.22 | Pain management for medical abortion before 14 weeks' gestation: A systematic review. ( Cameron, ST; Morroni, C; Reynolds-Wright, JJ; Woldetsadik, MA, 2022) |
| "The combination of ibuprofen/paracetamol, taken immediately after initial endodontic therapy and root canal preparation in teeth with irreversible pulpitis, reduced post-endodontic pain (ClinicalTrials." | 5.22 | Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain. ( Abubakr, NH; Elzaki, WM; Ibrahim, YE; Ziada, HM, 2016) |
| "Sickle With Ibuprofen and Morphine (SWIM) trial was designed to assess whether co-administration of ibuprofen (a non-steroidal anti-inflammatory drug) resulted in a reduction of opioid consumption delivered by patient-controlled analgesia (PCA) for acute pain in sickle cell disease." | 5.22 | SWIM (sickle with ibuprofen and morphine) randomised controlled trial fails to recruit: lessons learnt. ( Alexander, L; Amos, C; Anie, KA; Buckton, J; Cho, G; Doré, CJ; Hemmaway, C; Kahan, B; Kiilu, P; Layton, M; Meredith, S; Sutton, D, 2016) |
| "The aim of this randomized clinical study was to investigate the effectiveness of acetaminophen 650 mg or liquefied ibuprofen 400 mg in pain control of orthodontic patients during separation with an elastic separator." | 5.22 | Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial. ( Ghadirian, H; Hosseinzadeh Nik, T; Ostad, SN; Shahsavari, N, 2016) |
| "Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking." | 5.22 | Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016) |
| "Although liposomal bupivacaine had some effect on soft tissue anesthesia, it did not reduce pain to manageable clinical levels in patients presenting with untreated, symptomatic irreversible pulpitis." | 5.22 | Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial. ( Beck, M; Bultema, K; Drum, M; Fowler, S; Nusstein, J; Reader, A, 2016) |
| "To evaluate if ibuprofen 800mg reduces pain with intrauterine device (IUD) insertion among U." | 5.20 | Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial. ( Bednarek, PH; Creinin, MD; Cwiak, C; Espey, E; Jensen, JT; Reeves, MF, 2015) |
| "The main purpose of the study was to determine the safety profile and efficacy of intravenous ibuprofen administered over 5 to 10 minutes for the treatment of pain or fever in hospitalized patients." | 5.20 | The shortened infusion time of intravenous ibuprofen part 1: a multicenter, open-label, surveillance trial to evaluate safety and efficacy. ( Ayad, SS; Bergese, SD; Candiotti, K; Gan, TJ; Soghomonyan, S, 2015) |
| "This study aims to evaluate and compare the effect of pre-procedural administration of acetaminophen, ibuprofen, and meloxicam in reducing pain after separator placement." | 5.20 | Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial. ( Babanouri, N; Oshagh, M; Salehi, P; Torkan, S; Zarif Najafi, H, 2015) |
| "The aim of this double-blind, randomized, placebo-controlled clinical study was to evaluate the analgesic effects of preoperative/postoperative ibuprofen and acetaminophen use after bonding and to find a relation between the pain level and the amount of prostaglandin released." | 5.19 | Effects of various analgesics on the level of prostaglandin E2 during orthodontic tooth movement. ( Bostanoglu, E; Demirbilek, M; Polat-Ozsoy, O; Tunçer, Z, 2014) |
| " In a randomized controlled trial, we evaluated whether oral acetaminophen or ibuprofen reduced the pain experienced during pin removal." | 5.19 | Percutaneous pin removal in the outpatient clinic--do children require analgesia?: a randomized controlled trial. ( Abdullah, SN; Allen, JC; Lim, KB; Ong, LL; Tan, SS; Wong, ML, 2014) |
| "Administration of 1 g paracetamol and 600 mg ibuprofen one hour prior to office hysteroscopy decreased statistically the occurrence of non-pain side effects such as nausea, emesis, and hypotension." | 5.19 | Evaluation of pain in office hysteroscopy with prior analgesic medication: a prospective randomized study. ( De Santiago, J; Teran-Alonso, MJ; Usandizaga, R; Zapardiel, I, 2014) |
| " Our objective was to determine whether morphine administered orally has superior efficacy to ibuprofen in fracture-related pain." | 5.19 | Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial. ( Ali, S; Bale, M; Bhullar, G; Howard, J; Langford, C; Lim, R; Lin, K; Mainprize, D; Papini, A; Poonai, N; Rieder, MJ; Stitt, L; Teefy, J, 2014) |
| "To compare the efficacy of a combination of codeine with ibuprofen to ibuprofen alone on the intensity of pain experienced by children presenting to the ED with a musculoskeletal trauma to a limb." | 5.17 | Efficacy of an ibuprofen/codeine combination for pain management in children presenting to the emergency department with a limb injury: a pilot study. ( Fortin, C; Gouin, S; Julien, M; Le May, S; Messier, A; Robert, MA, 2013) |
| "Pre-emptive ibuprofen treatment was found to be more effective than a placebo in pain prevention, as determined by a significantly lower need for additional analgesia: 11 of 29 (38%) vs." | 5.16 | Pre-emptive effect of ibuprofen versus placebo on pain relief and success rates of medical abortion: a double-blind, randomized, controlled study. ( Avraham, S; Duvdevani, NR; Frenkel, Y; Gat, I; Haas, J; Seidman, DS, 2012) |
| "The aim of this study was to compare the efficacy of ibuprofen, viscoelastic bite wafers, and chewing gum in reducing orthodontic pain." | 5.16 | Pain reduction after initial archwire placement in orthodontic patients: a randomized clinical trial. ( Ahrari, F; Alizadeh, S; Farzanegan, F; Zebarjad, SM, 2012) |
| "We measured detection and tolerance thresholds for electrically induced pain in the ear lobe in healthy subjects (10 male, 10 female) to study sex differences in expectancy following either ibuprofen 800 mg or placebo in four different expectancy states." | 5.16 | Sex differences in analgesic response to ibuprofen are influenced by expectancy: a randomized, crossover, balanced placebo-designed study. ( Butcher, BE; Carmody, JJ, 2012) |
| "Dalteparin is superior to the NSAID ibuprofen in preventing extension of superficial thrombophlebitis during the 14-day treatment period with similar relief of pain and no increase in bleeding." | 5.16 | A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis. ( Aston, CE; Rathbun, SW; Whitsett, TL, 2012) |
| "Ibuprofen is a non-selective cyclo-oxygenase (COX)-1/COX-2 inhibitor used to treat pain conditions and inflammation." | 5.16 | Characteristics and clinical implications of the pharmacokinetic profile of ibuprofen in patients with knee osteoarthritis. ( Corigliano, A; De Sarro, G; Falcone, D; Galasso, O; Gallelli, L; Gasparini, G; Longo, P; Palleria, C; Saccà, S; Savino, R; Southworth, SR; Terracciano, R; Urzino, A, 2012) |
| "Acetaminophen alone may not be as effective in reducing pain-related physiological and behavioral changes as acetaminophen plus codeine or ibuprofen plus midazolam during diagnostic tympanocentesis." | 5.15 | Pain management in young children undergoing diagnostic tympanocentesis. ( Chandra, A; Colborn, DK; Hoberman, A; Hooper, EG; Kurs-Lasky, M; Reis, EC; Rockette, HE; Shaikh, N, 2011) |
| "This double-blind, randomized controlled study evaluated etoricoxib (90 and 120 mg), ibuprofen (600 mg), and acetaminophen (600 mg/codeine) (60 mg, (A/C)) in patients aged ≥ 18 years with moderate or severe pain after surgical extraction of ≥ 2 third molars (≥ 1 impacted)." | 5.15 | Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model. ( Bandy, DP; Boice, J; Christensen, SE; Daniels, SE; Liu, H; Losada, MC; Mehta, A; Peloso, PM, 2011) |
| "Our objective was too assess the effectiveness of 3 analgesics (ibuprofen, naproxen sodium, and acetaminophen) and a placebo administered before and after the placement of separators in reducing the severity of postseparator placement pain." | 5.15 | Effects of analgesics on orthodontic pain. ( Fillingim, R; Logan, H; McGorray, SP; Patel, S; Wheeler, TT; Yezierski, R, 2011) |
| "The objective of this study was to evaluate the benefit of a seven-day buprenorphine transdermal patch for patients with chronic musculoskeletal pain previously receiving long-term treatment with ibuprofen or diclofenac alone." | 5.15 | [Application of a seven-day buprenorphine transdermal patch in multimorbid patients on long-term ibuprofen or diclofenac]. ( Böhme, K; Heckes, B; Thomitzek, K, 2011) |
| "Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis." | 5.15 | A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. ( Aspley, S; Doherty, M; Gibb, I; Goulder, M; Hawkey, C; Hill, N; Reader, S, 2011) |
| "To investigate the effect of 12 weeks of strength training in combination with a nonsteroidal anti-inflammatory drug (NSAID), glucosamine, or placebo on muscle cross-sectional area (CSA), strength (primary outcome parameters), and function, power, pain, and satellite cell number (secondary outcome parameters) in patients with knee osteoarthritis (OA)." | 5.15 | Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients. ( Aagaard, P; Beyer, N; Hansen, M; Holm, L; Kjaer, M; Mackey, AL; Petersen, SG, 2011) |
| "In patients experiencing acute visceral pain as a result of primary dysmenorrhea, dexibuprofen was associated with a dose-dependent effective analgesia; this effect was at least equivalent to that of the double dose of ibuprofen." | 5.14 | ADIDAC trial: analgesia with dexibuprofen versus ibuprofen in patients suffering from primary dysmenorrhea: a crossover trial. ( Kaehler, ST; Kollenz, C; Phleps, W, 2009) |
| "In this cohort of adult ED patients with distal ureteral calculi, treatment with tamsulosin did not substantially improve any of the studied outcome measures compared with treatment with ibuprofen and oxycodone alone." | 5.14 | Tamsulosin for ureteral stones in the emergency department: a randomized, controlled trial. ( Ferre, RM; Perron, AD; Strout, TD; Wasielewski, JN, 2009) |
| "This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting." | 5.14 | Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial. ( Friday, JH; Harley, JR; Kanegaye, JT; McCaslin, I; Zheng, A, 2009) |
| "One-hundred and seven (107) patients with primary knee osteoarthritis (OA) with pain score of > or =5 were randomized to receive ibuprofen 800 mg per day or C." | 5.14 | Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. ( Chinswangwatanakul, P; Kuptniratsaikul, V; Thamlikitkul, V; Thanakhumtorn, S; Wattanamongkonsil, L, 2009) |
| "We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)." | 5.14 | A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. ( Brousseau, DC; Drendel, AL; Gorelick, MH; Kim, MK; Lyon, R; Weisman, SJ, 2009) |
| "Group A, receiving ibuprofen before and after separator placement, experienced significantly less pain (P <0." | 5.14 | Effects of preoperative ibuprofen on pain after separator placement. ( Fillingim, R; Logan, H; Marris, CK; McGorray, SP; Minor, V; Wheeler, TT; Yezierski, R, 2009) |
| " In allodynic patients with moderate-to-severe headache, rizatriptan resulted in greater pain relief compared with ibuprofen." | 5.14 | A comparison of migraine patients with and without allodynic symptoms. ( Kalita, J; Misra, UK; Yadav, RK, 2009) |
| "To study the effects of a paracervical block with combined ketorolac and lidocaine on perceived pain during first-trimester surgical abortion." | 5.14 | Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial. ( Burke, A; Cansino, C; Edelman, A; Jamshidi, R, 2009) |
| "In a randomized double-blinded clinical trial, 150 patients (50 per group) with irreversible pulpitis were given placebo, 600 mg ibuprofen, or 75 mg indomethacin 1 hour before local anesthesia." | 5.14 | The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis. ( Abbott, PV; Ashouri, R; Askarifard, S; Nakhaee, N; Pardakhti, A; Parirokh, M; Rekabi, AR, 2010) |
| " They were randomized to receive ibuprofen or paracetamol when pain relief was necessary." | 5.14 | Ibuprofen and paracetamol for pain relief during medical abortion: a double-blind randomized controlled study. ( David, LB; Livshits, A; Machtinger, R; Moshe-Zahav, A; Seidman, DS; Spira, M, 2009) |
| " Forty-eight hours after the first dressing application, the mean concentration of ibuprofen in the wound exudate reached a constant level of 35 +/- 21 microg/ml." | 5.13 | Combined use of an ibuprofen-releasing foam dressing and silver dressing on infected leg ulcers. ( Bech-Thomsen, N; Gottrup, F; Jørgensen, B; Karlsmark, T; Sibbald, RG, 2008) |
| "To test the efficacy of ibuprofen in reducing needle electromyography (EMG) pain we studied 30 healthy volunteers randomized to receive placebo or ibuprofen (400 mg) 2 h before EMG using concentric needle electrodes in four muscles." | 5.13 | Prospective double-blind crossover trial of ibuprofen in reducing EMG pain. ( El-Salem, K; Shakhatreh, M, 2008) |
| "To compare an ibuprofen-releasing foam dressing (Biatain Ibu, ColoplastA/S) with local best practice in the treatment of painful exuding wounds." | 5.13 | Effect of an ibuprofen-releasing foam dressing on wound pain: a real-life RCT. ( Altindas, M; Johannesen, N; Jortikka, A; Orsted, H; Palao i Domenech, R; Persson, LM; Ram, A; Romanelli, M; Schäfer, E; Slonková, V; Tsiftsis, DD, 2008) |
| "To explore the factors that influence older people's decision making regarding use of topical or oral ibuprofen for their knee pain." | 5.13 | Influences on older people's decision making regarding choice of topical or oral NSAIDs for knee pain: qualitative study. ( Anwer, Y; Carnes, D; Harding, G; Parsons, S; Underwood, M, 2008) |
| "The study was conducted to determine whether tramadol is more effective than ibuprofen for reducing pain during uterine aspiration for abortion." | 5.13 | A randomized trial of tramadol versus ibuprofen as an adjunct to pain control during vacuum aspiration abortion. ( Gilliam, M; Romero, I; Turok, D, 2008) |
| "We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol." | 5.13 | [Influence of adjuvant pain medication on quality of life in the treatment of postmenopausal osteoporosis]. ( Buttgereit, F; Krocker, D; Perka, C; Ullrich, H, 2008) |
| "Mild moxibustion cannot only effectively treat PD but also relieve pain in comparison with ibuprofen." | 5.12 | Comparative efficacy and dysmenorrhea score of 6 object-separated moxibustions for the treatment of Chinese patients with dysmenorrhea: A systematic review and network meta-analysis. ( Cai, MJ; Chen, JY; Huang, PD; Huang, XY; Lv, ZH; Wu, ZX, 2021) |
| "Acetaminophen 650 mg or ibuprofen 400 mg taken 1 hour prior to separator placement can reduce pain associated with the procedure." | 5.12 | Pharmacological Means of Pain Control during Separator Placement: A Systematic Review. ( Arishi, SA; Ghazwani, LY; Ghoussoub, MS; Jafer, MA; Patil, S; Sharawi, NA; Somaili, AMH; Somaili, RM; Sumayli, AH; Sumayli, MA, 2021) |
| "Cobrotoxin produces intense analgesia but it has an onset of response of 1-3 h which hampers its clinical use in cancer pain." | 5.12 | Cobrotoxin-containing analgesic compound to treat chronic moderate to severe cancer pain: results from a randomized, double-blind, cross-over study and from an open-label study. ( Bruno, M; Feng, FY; Huang, FL; Paradiso, A; Song, ST; Xie, GR; Xu, JM; Xu, LG; Yang, Y; Zhang, CZ, 2006) |
| "This study was undertaken to determine whether 400 mg of prophylactic ibuprofen can alleviate pain from insertion of an intrauterine device (IUD) and to measure level of pain with improved techniques." | 5.12 | Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen. ( Chen, PL; Croxatto, H; Hubacher, D; Lillo, S; Reyes, V; Zepeda, A, 2006) |
| "Our goal was to determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries." | 5.12 | A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. ( Clark, E; Correll, R; Gaboury, I; Passi, B; Plint, AC, 2007) |
| "The aim of the study was to evaluate a novel foam dressing with continuous low-level release of ibuprofen (Biatain-Ibu foam dressing, Coloplast A/S, Humlebaek, Denmark) in persons with leg ulcers compared to local best practice." | 5.12 | A pilot (real-life) randomised clinical evaluation of a pain-relieving foam dressing: (ibuprofen-foam versus local best practice). ( Coutts, P; Fierheller, M; Sibbald, RG; Woo, K, 2007) |
| "To compare efficacy of pain syndrome relief in osteoarthrosis at conventional administration and ultraphonophoresis of ibuprofen (nurofen gel), we applied ultraphonophoresis of 5% gel nurofen to affected joints of 20 patients of the study group (twice a day with a 5-6 hour interval; the third time the gel was applied locally in the evening)." | 5.12 | [Efficacy of ibuprofen (nurofen gel) ultraphonophoresis for pain relief in osteoarthrosis]. ( Serikov, NP, 2007) |
| "This prospective, randomized, double-blinded, clinical trial compared the effectiveness of oxycodone, ibuprofen, and the combination in children (age, 6-18 years), with pain from a suspected orthopedic injury." | 5.12 | Effectiveness of oxycodone, ibuprofen, or the combination in the initial management of orthopedic injury-related pain in children. ( Godambe, SA; Koller, DM; Lorenz, D; Myers, AB, 2007) |
| "Patients with mild to moderate pain were randomised to either: paracetamol up to 3 g/d, aspirin up to 3 g/d or ibuprofen up to 1200 mg/d for 7 days." | 5.11 | A large simple clinical trial prototype for assessment of OTC drug effects using patient-reported data. ( Jones, JK; Moore, N; Parc, JM; Schneid, H; Van Ganse, E; Wall, R, 2005) |
| "There was a statistically significant difference between pain measured by VAS, skin temperature and pain detection threshold measured at pad sites with pre-applied ibuprofen 5% cream and those with pre-applied aqueous cream, after elective DC cardioversion." | 5.11 | The effect of topical non-steroidal anti-inflammatory cream on the incidence and severity of cutaneous burns following external DC cardioversion. ( Ambler, JJ; Deakin, CD; Zideman, DA, 2005) |
| "This study will provide new evidence on the overall costs and benefits of treating chronic knee pain with either oral or topical ibuprofen." | 5.11 | TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care: a randomised controlled trial with patient preference study. [ISRCTN79353052]. ( Ashby, D; Cross, PL; Harding, G; Hennessy, EM; Letley, L; Parsons, S; Spencer, AE; Underwood, M, 2005) |
| "The goal of this study was to compare the efficacy and safety of OTC doses of naproxen (400 mg) and naproxen/naproxen sodium (200/220 mg) with acetaminophen (1000 mg), ibuprofen (200 mg), and placebo in the treatment of primary dysmenorrhea." | 5.10 | Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. ( Akin, MD; Dawood, MY; Milsom, I; Minic, M; Niland, NF; Spann, J; Squire, RA, 2002) |
| "The purpose of this study was to determine whether a common bromelain regimen or common ibuprofen regimen are effective in resolving pain and muscle dysfunction associated with delayed onset muscle soreness of the elbow flexors." | 5.10 | Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management. ( Edwards, JE; Ingersoll, CD; Merrick, MA; Stone, MB, 2002) |
| "2 g daily), aspirin and paracetamol (both up to 3 g daily) for up to seven days, in patients with mild to moderate pain resulting from cold/flu symptoms or sore throat (CF/ST) (n = 2,815)." | 5.10 | Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain. ( Cairns, R; Le Parc, JM; Moore, N; Schneid, H; van Ganse, E; Wall, R, 2002) |
| "Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor used to treat pain." | 5.10 | A randomized, clinical trial comparing oral celecoxib 200 mg, celecoxib 400 mg, and ibuprofen 600 mg for acute pain. ( Goldberg, J; Kenwood, A; Lavery, R; Salo, DF; Shapiro, T; Varma, V, 2003) |
| "Pretreatment with ibuprofen before major hip surgery does not improve the pain scores or reduce morphine requirement but significantly increases blood loss." | 5.10 | Prior ibuprofen exposure does not augment opioid drug potency or modify opioid requirements for pain inhibition in total hip surgery. ( Bugter, ML; Dirksen, R; Jhamandas, K; Milne, B; Slappendel, R; Weber, EW, 2003) |
| "Sore throat pain provided a sensitive model to assess the analgesic efficacy of class I analgesics and discriminated between the analgesic efficacy of ibuprofen and paracetamol." | 5.09 | Use of a simple pain model to evaluate analgesic activity of ibuprofen versus paracetamol. ( Bhagat, K; Lala, I; Leech, P; Montgomery, L, 2000) |
| " A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain." | 5.09 | Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model. ( Dallob, A; De Lepeleire, I; De Schepper, P; Ehrich, EW; Gertz, BJ; Mehlisch, DR; Porras, A; Riendeau, D; Seibold, JR; Van Hecken, A; Wittreich, J; Yuan, W, 1999) |
| "5 mg and ibuprofen 200 mg with that of combination codeine 30 mg and acetaminophen 300 mg for the treatment of chronic pain." | 5.09 | Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain. ( Damask, MJ; de Padova, A; Doyle, RT; Jiang, JG; Landau, CJ; Morris, E; Palangio, M, 2000) |
| "None of the therapies-standard care (ice, elevation, immobilization), standard care with ibuprofen, or standard care with music distraction-provided clinically significant pain relief to patients who had minor musculoskeletal trauma (ie, sprains and fractures) and moderate pain at triage." | 5.09 | The effect of standard care, ibuprofen, and music on pain relief and patient satisfaction in adults with musculoskeletal trauma. ( Marcantonio, R; Paice, J; Spiller, M; Tanabe, P; Thomas, R, 2001) |
| "To determine whether greater pain intensity at initiation of treatment predicted better response to ibuprofen than to acetaminophen in subjects with knee osteoarthritis (OA)." | 5.09 | Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis. ( Bradley, JD; Brandt, KD; Katz, BP, 2001) |
| "To compare the treatment potential of glucosamine sulfate (GS) and ibuprofen in patients diagnosed with temporomandibular joint (TMJ) osteoarthritis (OA)." | 5.09 | Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. ( Major, PW; Prasad, NG; Thie, NM, 2001) |
| "Ibuprofen and acetaminophen with codeine had similar analgesic properties in the first 24 hours post partum (mean pain rating 3." | 5.09 | Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial. ( Douglas, MJ; Grange, CS; Janssen, PA; Peter, EA, 2001) |
| "Phase 1: ibuprofen reduced pain scores more than placebo with the improvement being greatest for the postoperative period." | 5.08 | Pain control in abortion. ( Rawling, M; Wiebe, ER, 1995) |
| "To evaluate the efficacy of IM ketorolac versus that of oral ibuprofen in acute musculoskeletal pain." | 5.08 | Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995) |
| "Sixty female out-patients suffering from moderate to severe primary dysmenorrhea, aged 14-40 years (mean 27 years), entered this randomized, double-blind, 3-period, within-patient study, evaluating the efficacy and tolerability of diclofenac dispersible 46." | 5.08 | Comparative efficacy of diclofenac dispersible 50 mg and ibuprofen 400 mg in patients with primary dysmenorrhea. A randomized, double-blind, within-patient, placebo-controlled study. ( Bakshi, R; Fedele, L; Marchini, M; Pistai, R; Tozzi, L, 1995) |
| "Since both (R)- and (S)-enantiomers of ibuprofen may act on the central nervous system, we investigated their plasma and cerebrospinal fluid (CSF) concentrations in 46 patients with nerve-root compression pain requiring a lumbar puncture." | 5.08 | Stereoselective disposition of ibuprofen enantiomers in human cerebrospinal fluid. ( Bannwarth, B; Dehais, J; Gaucher, A; Gillet, P; Laborde, C; Lapicque, F; Netter, P; Pehourcq, F; Schaeverbeke, T, 1995) |
| "The aim of this study was to compare the dose-related effects of both ibuprofen tablets and ibuprofen effervescent [placebo, 400 and 800 mg ibuprofen (Aktren)] on phasic pain." | 5.08 | Comparison of the antinociception produced by two oral formulations of ibuprofen: ibuprofen effervescent vs ibuprofen tablets. ( Cramer, O; Geisslinger, G; Hummel, T; Kobal, G; Mohammadian, P; Pauli, E, 1997) |
| "As described earlier, administration of ibuprofen was followed by a decrease in tonic pain but-relative to placebo-an increase in correlates of phasic pain, indicating a specific effect of ibuprofen on the interaction between the pain stimuli under these special experimental conditions." | 5.08 | The negative mucosal potential: separating central and peripheral effects of NSAIDs in man. ( Hummel, T; Kobal, G; Kraetsch, H; Lötsch, J, 1997) |
| " ketorolac is superior to oral ibuprofen in patients presenting to an ED in moderate to severe pain." | 5.08 | Intramuscular ketorolac vs oral ibuprofen in emergency department patients with acute pain. ( Neighbor, ML; Puntillo, KA, 1998) |
| "We used electrically induced pain in healthy young subjects to study gender differences in nociception and the analgesic efficacy of ibuprofen." | 5.08 | Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen. ( Carmody, JJ; Walker, JS, 1998) |
| " The aim of this study was to investigate the dose-related effects of ibuprofen (placebo, 400 and 800 mg rac-ibuprofen [Aktren], administered orally) on experimentally-induced tonic and phasic pain." | 5.07 | Dose-related effects of ibuprofen on pain-related potentials. ( Geisslinger, G; Gruber, M; Hummel, C; Hummel, T; Kobal, G, 1994) |
| "To assess the sore throat pain model in children as an assay for systemic analgesic agents in children under double-blind, placebo-controlled conditions, we conducted a single-dose parallel study that compared 10 mg/kg ibuprofen (n = 39), a new analgesic agent for children, and 15 mg/kg acetaminophen (n = 38), an approved analgesic for children, to placebo (n = 39) in children from 2 to 12 years of age with acute sore throat." | 5.07 | A placebo-controlled model for assaying systemic analgesics in children. ( Schachtel, BP; Thoden, WR, 1993) |
| "To compare carbon dioxide and nitrous oxide pneumoperitoneum with respect to intraoperative and postoperative pain during laparoscopic sterilization under local anesthesia." | 5.07 | The effect of nitrous oxide and carbon dioxide pneumoperitoneum on operative and postoperative pain during laparoscopic sterilization under local anesthesia. ( Ling, FW; Lipscomb, GH; McCord, ML; Summitt, RL, 1994) |
| "In order to compare the efficacy and tolerance of two drug formulations of ibuprofen, conventional tablets 600 mg QID (CI) and sustained-release tablets 1200 mg BID (SRI), a total of 147 patients in 7 centres in Denmark with nontraumatic shoulder pain were included in a double-blind dummy study." | 5.07 | Comparison of two ibuprofen formulations in the treatment of shoulder tendonitis. ( Andersen, F; Christensen, K; Christophersen, J; Friis, J; Ibfeldt, HH; Jarner, D; Korsgaard, J; Skinhøj, A; Toft, B, 1992) |
| "The pharmacokinetics and the relative bioavailability of a soluble granular form (sachets) of a pharmaceutical formulation containing ibuprofen (CAS 15687-27-1) and 1-arginine were investigated in healthy volunteers." | 5.07 | Activity and pharmacokinetics of a new oral dosage form of soluble ibuprofen. ( Ceppi Monti, N; Gazzaniga, A; Gianesello, V; Lodola, E; Stroppolo, F, 1992) |
| "In a randomized, double-blind trial, 184 patients with chronic knee pain due to osteoarthritis were given either 2400 or 1200 mg of ibuprofen per day or 4000 mg of acetaminophen per day." | 5.07 | Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. ( Bradley, JD; Brandt, KD; Kalasinski, LA; Katz, BP; Ryan, SI, 1991) |
| " The analgesic efficacy of single oral doses (400 mg, 800 mg) of ibuprofen on argon laser-induced pain was studied in a double-blind, placebo controlled, three way cross-over comparison." | 5.06 | A double-blind, placebo controlled, cross-over comparison of the analgesic effect of ibuprofen 400 mg and 800 mg on laser-induced pain. ( Arendt-Nielsen, L; Bjerring, P; Nielsen, JC; Petterson, KJ, 1990) |
| "Thirty subjects with chronic moderate to severe pain who were receiving oxycodone/acetaminophen (oxy/APAP) for analgesia were initially evaluated for at least 7 days for oxy/APAP requirements for pain control." | 5.06 | The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain. ( Drew, J; Stambaugh, JE, 1988) |
| "Under double-blind, crossover conditions, 43 women with primary dysmenorrhea received ketoprofen, ibuprofen, and placebo during three consecutive menstrual cycles." | 5.06 | Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison. ( Mehlisch, DR, 1988) |
| "The analgesic efficacy of single doses of oral morphine sulphate solution (10 mg) and ibuprofen 600 mg was compared in 12 volunteers using a double-blind, double-dummy, placebo-controlled design on the cold pressor experimental pain model." | 5.06 | Morphine and ibuprofen compared using the cold pressor test. ( Hand, CW; Jones, SF; McQuay, HJ; Moore, RA, 1988) |
| " Patients with tonsillopharyngitis randomly received either 400 mg ibuprofen (n = 39), 1000 mg acetaminophen (n = 40), or placebo (n = 41)." | 5.06 | Sore throat pain in the evaluation of mild analgesics. ( Baybutt, RI; Fillingim, JM; Lane, AC; Schachtel, BP; Thoden, WR, 1988) |
| "A randomized, single-blind crossover trial tested the effect of 1,000 mg of ibuprofen on jaw muscle pain induced by maximum voluntary teeth clenching (MVC)." | 5.06 | Effect of ibuprofen on isometric contractions and associated pain of the human masseter muscle. ( Christensen, LV, 1987) |
| "A clinical trial comparing ibuprofen, 400, 600, and 800 mg, with aluminum ibuprofen, 400 mg, and placebo was conducted in patients with moderate or severe pain subsequent to third molar extraction." | 5.06 | The correlation between blood levels of ibuprofen and clinical analgesic response. ( Laska, EM; Marrero, I; McCormick, N; Olson, N; Siegel, C; Sunshine, A, 1986) |
| "This is a narrative review of the published literature on IV ibuprofen (IVIB) as one of the drugs used in multimodal pain management in inpatients and outpatients pre- and postoperatively and for nonsurgical pain or fever." | 5.05 | Narrative Summary of Recently Published Literature on Intravenous Ibuprofen. ( Sellers, JA; Southworth, SR, 2020) |
| "Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children." | 5.05 | Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis. ( Braithwaite, I; Dalziel, SR; McKinlay, CJD; Tan, E, 2020) |
| "43 patients with osteoarthritis of the knee and/or hip(s) were treated with suprofen 800 mg/day or ibuprofen 1,600 mg/day for 14 days." | 5.05 | Comparison of suprofen and ibuprofen in the treatment of pain secondary to osteoarthritis. ( Schuermans, Y, 1983) |
| "In a double-blind parallel group randomised study 191 patients with acute sprains and strains of ankle, hip, shoulder or knees were treated with either 400 mg sulindac or 1200 mg ibuprofen per day for 4 days; of these, 176 completed the trial." | 5.05 | Sulindac versus ibuprofen in sprains and strains. ( Currie, WJ; Fyvie, A; Hayes, TB; Janke, PG; Vandenburg, MJ, 1984) |
| "The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study." | 5.05 | Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea. ( Andersch, B; Milsom, I, 1984) |
| "An open, multi-centre study in general practice was carried out in 1842 patients presenting with non-serious painful conditions to assess the effectiveness and tolerance of ibuprofen." | 5.05 | A multi-centre general practice study evaluating the efficacy and tolerance of ibuprofen in common painful conditions. ( Benvenuti, C; Beretta, A; Longoni, A; Pickvance, NJ, 1984) |
| "A double-blind crossover study compared sodium meclofenamate (300 mg daily) and ibuprofen (900 mg daily) in thirty patients with osteoarthritis." | 5.05 | Short-term treatment of osteoarthritis: a comparison of sodium meclofenamate and ibuprofen. ( Accardo, S; Cimmino, MA; Cutolo, M; Samantà, E, 1982) |
| "1 Twenty-four patients suffering from severe pain due to chronic occlusive arterial disease of the legs were given oral doses of indoprofen (200 mg), ibuprofen (300 mg) and placebo." | 5.05 | Response of pathological ischaemic muscle pain to analgesics. ( Battistini, C; Lampugnani, R; Mandelli, V; Sacchetti, G, 1980) |
| "The efficacy of ibuprofen and naproxen-sodium for the treatment of primary dysmenorrhea was evaluated in a double-blind cross-over study in 57 otherwise healthy women." | 5.05 | Ibuprofen and naproxen-sodium in the treatment of primary dysmenorrhea: a double-blind cross-over study. ( Andersch, B; Milsom, I, 1985) |
| "Benorylate and ibuprofen appear to be useful drugs for pain relief in rheumatoid arthritis but benorylate would appear to have a slightly better effect on the pain score and it improved the grip strength more than the moderate doses of ibuprofen." | 5.04 | Comparison of benorylate and ibuprofen in the treatment of established rheumatoid arthritis. ( Coomes, EN; Darlington, LG, 1975) |
| "In a double-blind, multiclinic study, 437 patients with osteoarthritis were treated sequentially with ibuprofen, 1,800 mg/day, and placebo, or with aspirin, 3,600 mg/day, and placebo." | 5.04 | Ibuprofen in osteoarthritis. ( Brooks, CD; Donaldson, MS; Giansiracusa, JE; Koonce, ML; Lefton, TE; Ruoff, GE, 1977) |
| "A randomized double-blind study in ambulatory patients with osteoarthritis of hip and/or knee was conducted, comparing the efficacy and safety of diflunisal 500 mg daily with ibuprofen 1200 mg daily, and a period of 8 weeks." | 5.04 | A comparative clinical trial of diflunisal and ibuprofen in the control of pain in osteoarthritis. ( Keet, JG, 1979) |
| "Ninety patients with rheumatoid arthritis completed a double-blind crossover trial comparing fenoprofen, ibuprofen, ketoprofen, and naproxen." | 5.04 | Four new anti-inflammatory drugs: responses and variations. ( Balme, HW; Franklin, S; Huskisson, EC; Scott, J; Woolf, DL, 1976) |
| "In a double-blind multiclinic trial, a new nonsteroidal anti-inflammatory agent (ibuprofen) was compared with an established therapeutic agent (phenylbutazone-alka) for the treatment of osteoarthritis." | 5.04 | Ibuprofen versus buffered phenylbutazone in the treatment of osteoarthritis: double-blind trial. ( Donovan, JF; Hearron, MS; Levi, L; Moxley, TE; Royer, GL, 1975) |
| "- Paracetamol or ibuprofen should only be given when there is a combination of fever and pain." | 4.95 | [Revision of the Dutch College of General Practitioners practice guideline 'Children with fever']. ( Eizenga, WE; Opstelten, W, 2017) |
| "Ibuprofen is a non-steroidal anti-inflammatory drug frequently administered to children of various ages for relief of fever and pain and is approved as an over-the-counter medication in many countries worldwide." | 4.95 | Efficacy and Safety of Ibuprofen in Infants Aged Between 3 and 6 Months. ( Erb, TO; van den Anker, JN; Ziesenitz, VC; Zutter, A, 2017) |
| "Ibuprofen is the most widely used non-steroidal anti-inflammatory drug (NSAID) for the treatment of inflammation, mild-to-moderate pain and fever in children, and is the only NSAID approved for use in children aged ≥3 months." | 4.95 | Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal. ( Boner, A; Chiarugi, A; de Martino, M; De' Angelis, GL; Montini, G, 2017) |
| "To systematically review high-quality randomized controlled trials (RCTs) and meta-analysis on the effectiveness of use of ibuprofen and low-level laser therapy (LLLT) for pain control during fixed orthodontic appliance therapy." | 4.95 | Ibuprofen and Low-level Laser Therapy for Pain Control during Fixed Orthodontic Therapy: A Systematic Review of Randomized Controlled Trials and Meta-analysis. ( Bagheri, F; Eslamipour, F; Motamedian, SR, 2017) |
| "Ibuprofen is used to prevent high altitude headache (HAH) but its efficacy remains controversial." | 4.95 | Efficacy of ibuprofen on prevention of high altitude headache: A systematic review and meta-analysis. ( Jia, Z; Lu, H; Wang, R; Xiong, J, 2017) |
| "Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM." | 4.93 | Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016) |
| " All treatments except acetaminophen showed clinically significant improvement from baseline pain." | 4.91 | Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. ( Bannuru, RR; Kent, DM; McAlindon, TE; Schmid, CH; Vaysbrot, EE; Wong, JB, 2015) |
| " Lidocaine 2% gel, misoprostol, and most NSAIDs did not help reduce pain." | 4.91 | Interventions for pain with intrauterine device insertion. ( Allen, RH; Bartz, D; Bernholc, A; Hubacher, D; Lopez, LM; O'Brien, PA; Zeng, Y, 2015) |
| " Ibuprofen is widely available as an over-the-counter treatment for pain and fever." | 4.89 | Ibuprofen blood plasma levels and onset of analgesia. ( Mehlisch, DR; Sykes, J, 2013) |
| " In paediatric populations, ibuprofen and paracetamol (acetaminophen) are both commonly used over-the-counter medicines for the management of fever or mild-to-moderate pain associated with sore throat, otitis media, toothache, earache and headache." | 4.89 | Optimising the management of fever and pain in children. ( van den Anker, JN, 2013) |
| " For many years, ketorolac was the only intravenous NSAID available in the US, but in 2009 intravenous ibuprofen was approved by the US FDA for the treatment of pain and fever in adults." | 4.88 | Pharmacokinetics of intravenous ibuprofen: implications of time of infusion in the treatment of pain and fever. ( Smith, HS; Voss, B, 2012) |
| "To analyse major sources of evidence-based information on the efficacy and gastrointestinal tolerability of aspirin, used short-term, in over-the-counter (OTC) doses, to relieve acute pain and cold symptoms, including associated feverishness." | 4.88 | Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold. ( McCarthy, DM, 2012) |
| "Two trials (470 participants with venous leg ulcers) evaluated ibuprofen slow-release foam dressings for persistent venous leg ulcer pain." | 4.88 | Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Martyn-St James, M; Nelson, EA, 2012) |
| "Acetylsalicylic acid (ASA [aspirin]) is a commonly used over-the-counter drug for the treatment of pain, fever, or colds, but data on the safety of this use are very limited." | 4.87 | Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials. ( Baron, JA; Brueckner, A; Lanas, A; McCarthy, D; Senn, S; Voelker, M, 2011) |
| "Ibuprofen is as or more efficacious than acetaminophen for the treatment of pain and fever in adult and pediatric populations and is equally safe." | 4.86 | Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review. ( Pierce, CA; Voss, B, 2010) |
| "There is no evidence that ibuprofen dressings offer pain relief, as measured at the first evening of use, to people with painful venous leg ulcers compared with foam dressings or best practice." | 4.86 | Topical agents or dressings for pain in venous leg ulcers. ( Briggs, M; Nelson, EA, 2010) |
| "Ibuprofen is prescribed for children for the treatment of acute pain and fever, and for juvenile idiopathic arthritis." | 4.82 | A general overview of the use of ibuprofen in paediatrics. ( Autret-Leca, E, 2003) |
| "To summarize studies testing the efficacy and safety of single-dose acetaminophen and ibuprofen for treating children's pain or fever." | 4.82 | Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis. ( Champion, GD; Goodenough, B; Perrott, DA; Piira, T, 2004) |
| "Celecoxib is the first COX-2-specific inhibitor approved for relief of the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA), as well as for treatment of familial adenomatous polyposis." | 4.80 | Celecoxib clinical profile. ( Tive, L, 2000) |
| "Injections of diclofenac induced antinociception in visceral pain models (writhing test, colorectal distension test), but not in two models of somatosensory pain (tail-flick and hot-plate test)." | 4.79 | Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat. ( Björkman, R, 1995) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 4.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "This JAMA Patient Page describes the common oral nonprescription pain medications acetaminophen, aspirin, ibuprofen, and naproxen sodium." | 4.31 | Oral Nonprescription Pain Medications for Adults. ( Vordenberg, SE, 2023) |
| "To quantify the frequency and intensity of adverse events (AEs), commonly known as side effects, experienced by children receiving either ibuprofen or oxycodone for pain management following an acute fracture." | 4.12 | Quantifying the intensity of adverse events with ibuprofen and oxycodone: an observational cohort study. ( Ali, S; Carleton, B; Drendel, AL; Gourlay, K; Johnson, DW; Le May, S; Ortiz, S; Rosychuk, RJ; Watts, R; Yukseloglu, A, 2022) |
| " Pain medication consisted of ibuprofen 600 mg and paracetamol 1000 mg, first doses taken simultaneously with misoprostol and repeated, if needed, up to three times daily." | 3.96 | Pain during medical abortion in early pregnancy in teenage and adult women. ( Heikinheimo, O; Kemppainen, V; Mentula, M; Palkama, V, 2020) |
| " Effect of ibuprofen on muscle, hematological and renal function, hydric balance, pain, and performance during intense long-distance running." | 3.96 | Effect of Ibuprofen on Muscle, Hematological and Renal Function, Hydric Balance, Pain, and Performance During Intense Long-Distance Running. ( Aidar, FJ; Barros, NA; Cercato, LM; Chilibeck, P; da Silva, DS; de Matos, DG; de Souza, RF; Ferreira, ARP; Oliveira, AS, 2020) |
| " After being administered pregabalin, the subjects' pain tolerance thresholds in the cold pressor and pressure stimulation tests were significantly increased compared to the placebo group." | 3.91 | Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs. ( Butt, RP; Denney, WS; Dua, P; Groeneveld, GJ; Hay, JL; Okkerse, P; Siebenga, PS; van Amerongen, G, 2019) |
| " To assess the usefulness of this model for testing potential analgesics, three known synthetic pain medications were assessed (ibuprofen, acetaminophen and tramadol) along with three naturally occurring products (honokiol, tetrahydrocannabinol and cannabidiol)." | 3.88 | Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception. ( Achenbach, JC; Berrue, F; Ellis, LD; Hill, J; McDougall, JJ; Morash, M, 2018) |
| "Severe hyponatremia is rare when carbamazepine is used as monotherapy." | 3.88 | Walking hyponatremia syndrome of inappropriate antidiuretic hormone secretion secondary to carbamazepine use: a case report. ( Palacios Argueta, PJ; Pineda, A; Sánchez Rosenberg, GF, 2018) |
| "We recommend transdermal buprenorphine or codeine/ibuprofen for pain management during rehabilitation after distal radius fracture stabilized with VLP." | 3.88 | Pain Management during Rehabilitation after Distal Radius Fracture Stabilized with Volar Locking Plate: A Prospective Cohort Study. ( Lou, J; Luo, P; Yang, S, 2018) |
| "Women who used naproxen or opioids had slightly lower fecundability than women who did not use any pain-relieving medications; use of acetaminophen, aspirin and ibuprofen was not appreciably associated with fecundability." | 3.85 | Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study. ( Hatch, EE; McInerney, KA; Mikkelsen, EM; Rothman, KJ; Wesselink, AK; Wise, LA, 2017) |
| "In patients with multiple comorbidities, naproxen- and ibuprofen-containing regimens are more effective and cost-effective in managing OA pain than opioids, celecoxib or SOC." | 3.83 | Cost-effectiveness of nonsteroidal anti-inflammatory drugs and opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities. ( Collins, JE; Hunter, DJ; Jordan, JM; Katz, JN; Losina, E; Paltiel, AD; Smith, SR; Solomon, DH; Suter, LG; Yelin, E, 2016) |
| " The aim of this study was to assess whether differences in dissolution rates would affect the onset, magnitude, and duration of the time course of ibuprofen-mediating pain relief." | 3.83 | Bridging the Gap Between In Vitro Dissolution and the Time Course of Ibuprofen-Mediating Pain Relief. ( Cristofoletti, R; Dressman, JB, 2016) |
| " In particular, 14 and 15 were found to be more potent than morphine for both acute and inflammatory pain models and 100-fold more potent than gabapentin in a diabetic neuropathic pain model." | 3.81 | Antinociceptive Grayanoids from the Roots of Rhododendron molle. ( Li, Y; Liu, Y; Liu, YB; Lv, HN; Ma, SG; Qu, J; Yu, SS; Zhang, JJ, 2015) |
| " To investigate whether innate rodent burrowing is a useful alternative behavioural readout for assessment of analgesic efficacy, a complete Freund's adjuvant (CFA)-induced model of sub-chronic inflammation was used to compare the effects of naproxen, ibuprofen and pregabalin in weight-bearing (WB), open-field (OF) and burrowing assays." | 3.80 | Burrowing as a non-reflex behavioural readout for analgesic action in a rat model of sub-chronic knee joint inflammation. ( Christoph, T; Leipelt, A; Pasqualon, T; Read, SJ; Robens, A; Rutten, K; Schiene, K, 2014) |
| " These results suggest that ceftriaxone, particularly in combinations with ibuprofen, celecoxib, paracetamol, or levetiracetam, may provide useful approach to the clinical treatment of inflammation-related pain." | 3.80 | Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. ( Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA, 2014) |
| "The primary objective was to assess whether patients with a fever are treated with acetaminophen or ibuprofen more promptly than they are treated for pain." | 3.80 | Is fever treated more promptly than pain in the pediatric emergency department? ( Bair, J; Dvorkin, R; Glantz, S; Marguilies, J; Patel, H; Rosalia, A; Yens, DP, 2014) |
| "Ibuprofen and acetaminophen are frequently alternated or simultaneously used to treat fever or pain in children, while the evidence for the safety of such a combination is lacking." | 3.80 | Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system. ( Jiang, P; Sun, H; Wu, J; Yue, Z, 2014) |
| "9 mg/kg, CARR) hypersensitivity, whereas ibuprofen (CARR, mechanical allodynia) and celecoxib (CARR, thermal hyperalgesia; CFA, mechanical allodynia) failed to reach maximum efficacy." | 3.80 | S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. ( Gris, G; Merlos, M; Portillo-Salido, E; Vela, JM; Zamanillo, D, 2014) |
| " Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia." | 3.79 | Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. ( Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A, 2013) |
| " After adjusting for the use of ibuprofen and other PD risk factors, subjects with preceding pain symptoms had a higher incidence of PD than those without pain at baseline, and the hazard ratio was 1." | 3.79 | Preceding pain symptoms and Parkinson's disease: a nationwide population-based cohort study. ( Chang, HY; Chiang, YT; Lin, CH; Lin, HH; Wu, RM, 2013) |
| " Twenty-one patients with traumatic rib fractures treated with both narcotics and intravenous ibuprofen (IVIb) (Treatment) were retrospectively compared with 21 age- and rib fracture-matched patients who received narcotics alone (Control)." | 3.79 | Early intravenous ibuprofen decreases narcotic requirement and length of stay after traumatic rib fracture. ( Bayouth, L; Birrer, KL; Cheatham, ML; Promes, JT; Safcsak, K; Smith, CP, 2013) |
| "The aim of the study was to determine the most effective dose of Ibuprofen - one of the non-steroidal anti-inflammatory drugs frequently used in dental practice for pain management." | 3.79 | [Pain management in dentistry]. ( Gumberidze, NSh; Kandreli, MG; Mandzhavidze, NA; Vadachkoriia, NR, 2013) |
| "Children who have unresolved pain despite the use of either ibuprofen or acetaminophen should have their medication regimen reviewed to ensure they are receiving the medication at an adequate dose and interval." | 3.78 | Alternating acetaminophen and ibuprofen for pain in children. ( Goldman, RD; Smith, C, 2012) |
| " This study was undertaken to determine the nature of the interaction between codeine and celecoxib or etoricoxib in peritoneal irritation-induced visceral pain in mice." | 3.77 | Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice. ( Janovsky, M; Krsiak, M, 2011) |
| "To examine if wound aetiology has an effect on the pain-relieving properties of an ibuprofen-releasing foam dressing, which was previously shown to reduce pain in wounds of various aetiologies, compared with local best practice (LBP)." | 3.77 | Analgesic efficacy of an ibuprofen-releasing foam dressing compared with local best practice for painful exuding wounds. ( Arapoglou, V; Dimakakos, EP; Gjødsbøl, K; Glynn, C; Katsenis, K; Petersen, B; Schäfer, E; Syrigos, KN; Tsoutos, D; Zakopoulou, N, 2011) |
| "Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients." | 3.75 | Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009) |
| "A model of visceral pain consisting of intraperitoneal injection of acetic acid (writhing test) was used." | 3.75 | Guaifenesin enhances the analgesic potency of ibuprofen, nimesulide and celecoxib in mice. ( Dolezal, T; Krsiak, M; Sliva, J; Sykora, D; Vosmanska, M, 2009) |
| ", synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats." | 3.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| "Duloxetine, a selective but balanced serotonergic and noradrenergic reuptake inhibitor, was evaluated in the acute nociceptive pain models of tail flick and hot plate in mice and in the persistent and/or inflammatory pain models of acetic acid-induced writhing in mice, carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats, and capsaicin-induced mechanical allodynia in rats." | 3.73 | Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2005) |
| " The present study was undertaken to assess markers of inflammation, arthritis and pain in rats with adjuvant arthritis undergoing treatment with ibuprofen cream (Dolgit cream) and placebo." | 3.72 | Quantitative assessment of markers of inflammation, arthritis and pain in rats with adjuvant arthritis following the treatment with ibuprofen cream and placebo. ( Istok, R; Rovenský, J; Stancíková, M; Svík, K, 2003) |
| "(1) First-line treatment for both acute and chronic pain is paracetamol or, if necessary, ibuprofen, a nonsteroidal antiinflammatory drug." | 3.72 | Paracetamol + tramadol: new preparation. No advance. ( , 2003) |
| " Data from 46 trials of the effect of single-dose ibuprofen on post-operative pain are analysed and the results contrasted with those derived from classical and Bayesian summary statistic methods." | 3.71 | Bayesian random effects meta-analysis of trials with binary outcomes: methods for the absolute risk difference and relative risk scales. ( Spiegelhalter, DJ; Thompson, SG; Warn, DE, 2002) |
| "The aim of this study was to evaluate whether dexibuprofen meets the basic requirements of Dutch General Practitioners (GPs) for acceptance as an analgesic in mild to moderate pain." | 3.71 | Treatment of non-malignant pain in the Dutch GP population: an analysis of treatment standards, prescription habits and basic attitudes. ( Bon, A; Jongejan, RC, 2001) |
| "(1) This codeine-based syrup is indicated for the treatment of pain in children." | 3.70 | Codeine for child pain: new preparation. Helpful in some cases. ( , 1999) |
| "To compare the clinical efficacy of single doses of intramuscular ketorolac and oral ibuprofen in the emergency department (ED) treatment of acute pain." | 3.69 | NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac. ( Price, SD; Watson, WA; Wright, JM, 1994) |
| "The effects of combined single oral treatments with non-steroidal anti-inflammatory drugs (NSAIDs) and the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dextromethorphan (DM) on arthritic pain were examined in a rat model of adjuvant-induced arthritis." | 3.69 | Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats. ( Caruso, FS; Frenk, H; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1996) |
| " The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| "We report a case of biopsy-proven acute tubulointerstitial nephritis associated with a second course of flurbiprofen, a nonsteroidal anti-inflammatory drug of the propionic acid class." | 3.68 | Flurbiprofen-associated acute tubulointerstitial nephritis. ( Kaufhold, J; McCabe, K; Wilkowski, M, 1991) |
| "A double-blind three-way crossover design in the treatment of dysmenorrhea comparing a propionic acid derivative (ibuprofen) and a fenamate (mefenamic acid) with a placebo showed that both ibuprofen and mefenamic acid are generally superior to placebo." | 3.66 | A double-blind comparison of a propionic acid derivative (ibuprofen) and a fenamate (mefenamic acid) in the treatment of dysmenorrhea. ( Roy, S, 1983) |
| "Pain is one of the most common reasons for seeking medical intervention, and self-medication with over-the-counter medications and/or traditional herbal remedies has become increasingly popular." | 3.01 | Pharmacokinetic and pharmacodynamic herb-drug interactions of common over-the-counter pain medications. ( Sun, CK; Tsai, TH, 2023) |
| " Globally, the pharmacologic treatment of pain in pediatric patients is limited largely to nonopioid analgesics, and dosing must account for differences in age, weight, metabolism, and risk of adverse effects." | 3.01 | Common Selfcare Indications of Pain Medications in Children. ( Bell, J; Kachroo, P; Mossali, VM; Siddiqui, K; Zempsky, W, 2023) |
| " No difference in adverse events was observed between the two groups." | 2.87 | Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: An open-label randomized controlled trial. ( Wang, J, 2018) |
| " angustifolia alone and in combination with B." | 2.84 | Evaluation of the effect of Elaeagnus angustifolia alone and combined with Boswellia thurifera compared with ibuprofen in patients with knee osteoarthritis: a randomized double-blind controlled clinical trial. ( Hajhashemi, V; Karimifar, M; Sarrafchi, S; Soltani, R, 2017) |
| " Adverse drug reactions may be renal, gastrointestinal, hematological, or immunologic." | 2.82 | Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years. ( Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC, 2022) |
| "Pain is often cited as one of the worst features of medical abortion." | 2.82 | Two prophylactic medication approaches in addition to a pain control regimen for early medical abortion < 63 days' gestation with mifepristone and misoprostol: study protocol for a randomized, controlled trial. ( Dragoman, MV; Dung, DL; Grossman, D; Habib, N; Huong, NM; Kapp, N; Tamang, A, 2016) |
| "More subjects reached the strict time limit of 30 min (analysed by logistic regression and adjusted OR as a post-hoc analysis) under EA compared with most other experimental conditions." | 2.77 | The effect of electroacupuncture and tramadol on experimental tourniquet pain. ( Choi, KE; Dobos, G; Gabriel, T; Lüdtke, R; Michalsen, A; Musial, F; Rampp, T, 2012) |
| "Osteoporotic vertebral compression fractures (VCFs) are a major cause of increased morbidity in older patients." | 2.76 | Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures. ( Alibai, E; Farrokhi, MR; Maghami, Z, 2011) |
| "Endometriosis is associated with an inflammatory response." | 2.73 | Anti-TNF-alpha treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial. ( Cornillie, F; Craessaerts, M; Kennedy, S; Koninckx, PR; Timmerman, D, 2008) |
| "Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment." | 2.73 | Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. ( Dionne, RA; Hamza, M; Ramsay, ES; Wahl, SM; Wang, XM; Wu, TX, 2007) |
| "The ibuprofen-foam was regarded successful, if the pain relief on a 5-point verbal rating scale was higher than the comparator without compromising safety, including appropriate healing rate." | 2.73 | Less pain with Biatain-Ibu: initial findings from a randomised, controlled, double-blind clinical investigation on painful venous leg ulcers. ( Ahokas, TL; Arenbergerova, M; Ettler, K; Gottrup, F; Harding, K; Jünger, M; Jørgensen, B; Karlsmark, T; Price, P; Rimdeika, R; Sibbald, RG; Sulcaite, R; Venning, V; Vilkevicius, G; Vowden, P; Wortmann, S, 2007) |
| " Serial blood sample were collected for bioavailability studies." | 2.73 | Rapidly dissolving formulations for quick absorption during pain episodes: ibuprofen. ( Aghazadeh-Habashi, A; Jamali, F, 2008) |
| "In addition to providing acute postoperative pain relief, preoperative PVB seems to reduce the prevalence of chronic pain 1 yr after breast cancer surgery." | 2.72 | Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery. ( Bachmann, MS; Kairaluoma, PM; Pere, PJ; Rosenberg, PH, 2006) |
| "Diclofenac-K was superior to placebo (P < 0." | 2.71 | A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms. ( Frank, WO; Gold, MS; Grebe, W; Ionescu, E; Liu, JM, 2003) |
| "Naproxen and ibuprofen were more effective than acetaminophen in minimizing physical side effects of IFN beta-1a." | 2.71 | A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis. ( Filipi, M; Healey, K; Leuschen, MP, 2004) |
| " The main parameter was the incidence of clinical adverse events." | 2.70 | Efficacy and long-term safety of dexibuprofen [S(+)-ibuprofen]: a short-term efficacy study in patients with osteoarthritis of the hip and a 1-year tolerability study in patients with rheumatic disorders. ( Mayrhofer, F, 2001) |
| "Pain was evaluated at time 0 and at 30, 60, 90, and 120 minutes on a 10-mm visual analog scale (VAS)." | 2.69 | Patients' perceptions of route of nonsteroidal anti-inflammatory drug administration and its effect on analgesia. ( Istvan, DJ; Larkin, GL; Schwartz, NA; Turturro, MA, 2000) |
| "Ibuprofen was also better tolerated than diclofenac sodium (100 mg/day), the latter being associated with gastrointestinal side effects in a significant proportion of patients." | 2.68 | Ibuprofen and diclofenac sodium in the treatment of osteoarthritis: a comparative trial of two once-daily sustained-release NSAID formulations. ( Baumgartner, H; Blum, W; Bruhin, A; Gallachi, G; Goldinger, G; Saxer, M; Schwarz, HA; Trost, H, 1996) |
| " These data indicate that a prophylactic dosage of ibuprofen does not prevent CK release from muscle, but does decrease muscle soreness perception and may assist in restoring muscle function." | 2.67 | Effect of ibuprofen use on muscle soreness, damage, and performance: a preliminary investigation. ( Daniels, JC; Divine, JG; Hasson, SM; Niebuhr, BR; Richmond, S; Stein, PG; Williams, JH, 1993) |
| " Ibuprofen is associated with certain well-known gastrointestinal adverse effects that are related to dose and patient population." | 2.66 | Ibuprofen Safety at the Golden Anniversary: Are all NSAIDs the Same? A Narrative Review. ( Dowling, P; Paladini, A; Pergolizzi, JV; Varrassi, G, 2020) |
| " The 30% increase in analgesic effect may be of clinical benefit, and this trial design, cross-over with multiple dosing in out-patients, may be a sensitive test for analgesics, potentially more predictive of side-effect problems than single-dose studies." | 2.66 | Codeine 20 mg increases pain relief from ibuprofen 400 mg after third molar surgery. A repeat-dosing comparison of ibuprofen and an ibuprofen-codeine combination. ( Carroll, D; Juniper, RP; McQuay, HJ; Moore, RA; Watts, PG, 1989) |
| "Nabumetone is an appropriate choice of nonsteroidal anti-inflammatory drug for the treatment of sports injury." | 2.66 | Nabumetone in the treatment of skin and soft tissue injury. ( Jenner, PN, 1987) |
| "Twenty-eight patients presenting with sports injuries were randomly allocated to receive either 200 mg sulindac twice daily or 400 mg ibuprofen 3-times daily." | 2.65 | Differential efficacy of two non-steroidal anti-inflammatory drugs in the treatment of sports injuries. ( Currie, WJ; VandenBurg, MJ; Walker, JW, 1984) |
| "Indoprofen was well tolerated, and no side-effects were observed." | 2.65 | Indoprofen versus ibuprofen in osteoarthrosis: a short-term, double-blind, crossover trial. ( Bruni, G; Ferrati, GC; Innocenti, PF; Mandelli, V, 1979) |
| "The pharmacological agents approved for treating pain in these patients are few, also considering the recent limitation for codeine in children younger than 12 years." | 2.61 | Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview. ( Barbagallo, M; Sacerdote, P, 2019) |
| " Data suggesting that conditions associated with chronic liver damage reduce the dosing threshold for induction of liver failure are of particular concern." | 2.61 | Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered? ( Fernandes, L; Kellstein, D, 2019) |
| "Pain is an unpleasant side-effect that can be experienced during orthodontic procedures including debonding of fixed appliances." | 2.61 | Effectiveness of different debonding techniques and adjunctive methods on pain and discomfort perception during debonding fixed orthodontic appliances: a systematic review. ( Alharbi, F; Almuzian, M; Alomari, S; Mohammed, H; Rizk, MZ; Ulhaq, A, 2019) |
| "Fear of dental pain is a major barrier to treatment for children who need dental care." | 2.53 | Preoperative analgesics for additional pain relief in children and adolescents having dental treatment. ( Anand, P; Ashley, PF; MacDonald, LC; Moles, DR; Parekh, S, 2016) |
| "Ibuprofen (IBU) is an efficacious over-the-counter analgesic/antipyretic with adverse event (AE) rates comparable to placebo." | 2.52 | Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo. ( Jayawardena, S; Kellstein, D; Leyva, R, 2015) |
| "Fear of dental pain is a major barrier to children needing dental care." | 2.48 | Preoperative analgesics for additional pain relief in children and adolescents having dental treatment. ( Anand, P; Ashley, PF; Behbehani, A; Moles, DR; Parekh, S, 2012) |
| "Pain is the most common reason for seeking health care in the Western world and is a contributing factor in up to 80% of all emergency department (ED) visits." | 2.46 | Pain management of musculoskeletal injuries in children: current state and future directions. ( Ali, S; Beno, S; Drendel, AL; Kircher, J, 2010) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 2.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| " The evidence for modes of action of ibuprofen are considered in relation to its actions in controlling inflammation, pain and fever, as well as the adverse effects of the drug." | 2.45 | Ibuprofen: pharmacology, efficacy and safety. ( Rainsford, KD, 2009) |
| "Tramadol seems to be a potential useful analgesic for term neonates and infants, but has limited indications in (extreme) preterm neonates." | 2.44 | Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists. ( Allegaert, K; de Hoon, J; Naulaers, G; Van De Velde, M, 2008) |
| " It is generally well tolerated after single or multiple doses and short-term use is not expected to produce any of the serious adverse effects typically associated with the long-term use of opioids or NSAIDs." | 2.43 | Oxycodone/Ibuprofen combination tablet: a review of its use in the management of acute pain. ( Oldfield, V; Perry, CM, 2005) |
| "Pain is one of the most common reasons patients seek dental treatment." | 2.43 | Drugs for pain management in dentistry. ( Abbott, PV; Hargreaves, K, 2005) |
| " The review establishes that aspirin, paracetamol and ibuprofen are safe in OTC doses and that there is no evidence for any difference between the medicines as regards efficacy and safety for treatment of colds and flu (except in certain cases such as the use of aspirin in feverish children)." | 2.43 | Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. ( Eccles, R, 2006) |
| "Ibuprofen 400 mg has been shown to be as effective as aspirin 600 or 900 mg/day in models of moderate pain but superior to aspirin or paracetamol in more sensitive models such as dental pain." | 2.42 | Review of the analgesic efficacy of ibuprofen. ( Beaver, WT, 2003) |
| "Carprofen is a propionic acid-derived NSAID that has anti-inflammatory, analgesic, and antipyretic activity." | 2.40 | Use of carprofen for the treatment of pain and inflammation in dogs. ( Fox, SM; Johnston, SA, 1997) |
| "Chronic pain affects 75 million US citizens." | 2.40 | Non-NSAID pharmacologic treatment options for the management of chronic pain. ( Schnitzer, TJ, 1998) |
| " ECa 233 may be alternatively and safely used for treating chronic inflammatory TMD pain, showing an inverted U-shaped dose-response relationship with maximal effect at 100 mg/kg." | 1.91 | Standardized Centella asiatica (ECa 233) extract decreased pain hypersensitivity development in a male mouse model of chronic inflammatory temporomandibular disorder. ( Care, C; Chindasri, W; Pakaprot, N; Rotpenpian, N; Tantisira, MH; Tapechum, S; Tilokskulchai, K; Vattarakorn, A; Wanasuntronwong, A, 2023) |
| "The in-vivo pharmacodynamic (PD) studies were performed in mice." | 1.72 | Pharmacodynamic/pharmacokinetic correlation of optimized ibuprofen nanosuspensions having enhanced anti-inflammatory and antinociceptive activity. ( Bandarkar, F; Masocha, W; Nada, A, 2022) |
| " A two-compartment pharmacokinetic model with first-order elimination described disposition for both drugs." | 1.72 | Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers. ( Anderson, BJ; Atkinson, HC; Morse, JD; Stanescu, I, 2022) |
| "Pain is a major problem that burdens the health and economy of societies worldwide." | 1.72 | Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats. ( Al-Mousa, AA; Alsalem, MI; Altarifi, AA; Neubert, JK; Nuseir, KQ; Qaoud, AK; Younis, BA, 2022) |
| "Mechanical allodynia, heat hyperalgesia, biased weight-bearing, and hindpaw thickness were assessed 0." | 1.62 | Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats. ( Britch, SC; Craft, RM; Hewitt, KA, 2021) |
| "Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and anti-inflammatory actions." | 1.51 | The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel. ( De Logu, F; De Siena, G; Geppetti, P; Landini, L; Li Puma, S; Nassini, R; Patacchini, R; Poli, G; Preti, D; Tsagareli, MG; Tuccinardi, T, 2019) |
| " We determined prevalence of NSAID dosing exceeding the daily limit (EDL) and identified related user characteristics and dosing patterns among current ibuprofen users." | 1.48 | Exceeding the daily dosing limit of nonsteroidal anti-inflammatory drugs among ibuprofen users. ( Battista, DR; Kaufman, DW; Kelly, JP; Malone, MK; Shiffman, S; Weinstein, RB, 2018) |
| "The consequences of chronic insufficient sleep for health remain uncertain." | 1.46 | Decreased alertness due to sleep loss increases pain sensitivity in mice. ( Alexandre, C; Ferreira, A; Latremoliere, A; Miracca, G; Scammell, TE; Woolf, CJ; Yamamoto, M, 2017) |
| "When ibuprofen alone was administered, pain scores equal to or lower than 5/10 were associated with the greatest sensitivity and specificity for discharge." | 1.46 | Factors Associated With Discharge After Initial Emergency Treatment of Pediatric Migraine. ( Aravamuthan, BR; Mar, SS; Williams, KG, 2017) |
| "Acetaminophen was administered 2." | 1.46 | Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study. ( Moody, MA; Saleh, E; Swamy, GK; Walter, EB, 2017) |
| "Ibuprofen (15 mg/kg) was administered once a day." | 1.43 | Ibuprofen intake increases exercise time to exhaustion: A possible role for preventing exercise-induced fatigue. ( Bobinski, F; Bresciani, G; Della Pace, ID; Ferreira, J; Fighera, MR; Ineu, RP; Lima, FD; Pereira, ME; Rambo, LM; Ribeiro, LR; Rossato, MF; Royes, LF; Santos, AR; Silva, MA; Stamm, DN, 2016) |
| "Inflammatory and pain are major areas for drug discovery." | 1.42 | Evaluation of anti-inflammatory and analgesic effects of synthesized derivatives of ibuprofen. ( Dai, D; Deng, X; Huang, W; Lin, H; Qian, H; Qiu, Q; Wang, J, 2015) |
| "Diclofenac treatment produced dose-related reversal of CRANE at 0." | 1.42 | Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats. ( Bannon, AW; Joshi, SK; Zhu, CZ, 2015) |
| "Ibuprofen is a well established analgesic, anti-inflammatory and antipyretic NSAID." | 1.38 | Intravenous ibuprofen: in adults for pain and fever. ( Scott, LJ, 2012) |
| "Ibuprofen was used as a reference compound in each test." | 1.38 | Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu. ( Brownell, L; Hodges, M; Jia, Q; Yimam, M, 2012) |
| "For aspirin, differences were seen for male gender (relative risk (RR): 0." | 1.37 | Demographic, medical, and behavioral characteristics associated with over the counter non-steroidal anti-inflammatory drug use in a population-based cohort: results from the Multi-Ethnic Study of Atherosclerosis. ( Biggs, ML; Delaney, JA; Kronmal, RA; Psaty, BM, 2011) |
| "Although the diagnosis and treatment of slipped capital femoral epiphysis have been well described, the search for its cause and a method of early identification continues." | 1.37 | Three cases of slipped capital femoral epiphysis in one family. ( Leu, D; Papp, DF; Sargent, MC; Skelley, NW, 2011) |
| "Ibuprofen plasma concentration reached a Cmax of 74." | 1.36 | Ibuprofen transdermal ethosomal gel: characterization and efficiency in animal models. ( Ainbinder, D; Bercovich, R; Duchi, S; Shumilov, M; Touitou, E, 2010) |
| "Ibuprofen was used as reference." | 1.35 | Antinociceptive activity of Buddleja globosa (matico) in several models of pain. ( Apablaza, C; Arrau, S; Backhouse, N; Castro, C; Delporte, C; Farías, M; Goïty, L; Miranda, H; Negrete, R, 2008) |
| "He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated." | 1.34 | Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007) |
| "Thermal hyperalgesia was induced by mild heat injury (51 degrees C water for 20 s) which led to a 7-8 degrees C decrease of the noxious heat threshold." | 1.34 | Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model. ( Bölcskei, K; Horváth, D; Petho, G; Szolcsányi, J, 2007) |
| "Immunization pain is a global public health issue." | 1.34 | Routine immunization practices: use of topical anesthetics and oral analgesics. ( Ipp, M; Manley, J; Potash, L; Sgro, M; Shah, V; Taddio, A, 2007) |
| " Etoricoxib is partly metabolised by the cytochrome P450 isoenzyme CYP 3A4 and increases the bioavailability of ethinylestradiol." | 1.34 | Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain. ( , 2007) |
| "Ibuprofen based drugs were the most frequently used OTC in both surveys (57% Roper, 33% NCL)." | 1.33 | Patterns of use and public perception of over-the-counter pain relievers: focus on nonsteroidal antiinflammatory drugs. ( Cryer, B; Triadafilopoulos, G; Wilcox, CM, 2005) |
| "Colitis was induced in rats by an enema containing 2,4,6-trinitrobenzen sulfonic acid." | 1.32 | Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats. ( Ardid, D; Eschalier, A; Etienne, M; Jourdan, D; Millecamps, M, 2004) |
| "The writhing reaction reached a peak at 5-10 min after the injection of kaolin (0." | 1.28 | A new writhing model of factor XII activator-induced pain for assessment of non-steroidal anti-inflammatory agents. I. Kaolin-induced writhing in mice. ( Fujiyoshi, T; Iida, H; Kuwashima, M; Uematsu, T, 1989) |
| "Uterine leiomyomas are found in approximately 2% of pregnant women." | 1.28 | Complications of uterine leiomyomas in pregnancy. ( Dotters, DJ; Droegemeuller, W; Katz, VL, 1989) |
| "A 21-year-old woman with systemic lupus erythematosus (SLE) had meningismus, conjunctivitis, lymphadenopathy, and elevation of liver function values following ibuprofen therapy." | 1.26 | Tolmetin-induced aseptic meningitis. ( Barth, WF; Ruppert, GB, 1981) |
| " Long-term use of analgesic drugs in chronic pain usually produces negative behavioral complications that are more difficult to manage than the pain it was desired to eliminate." | 1.26 | Analgesic drugs in the management of pain. ( Halpern, LM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (10.86) | 18.7374 |
| 1990's | 56 (11.69) | 18.2507 |
| 2000's | 141 (29.44) | 29.6817 |
| 2010's | 174 (36.33) | 24.3611 |
| 2020's | 56 (11.69) | 2.80 |
| Authors | Studies |
|---|---|
| Tamura, Y | 1 |
| Yoshimoto, Y | 1 |
| Kunimoto, K | 1 |
| Tada, S | 1 |
| Tomita, T | 1 |
| Hino, K | 1 |
| Nakamura, H | 1 |
| Nagai, Y | 1 |
| Uno, H | 1 |
| Nishimura, H | 1 |
| Chatterjee, NR | 1 |
| Kulkarni, AA | 1 |
| Ghulekar, SP | 1 |
| Sujith, KV | 1 |
| Rao, JN | 1 |
| Shetty, P | 1 |
| Kalluraya, B | 1 |
| Nieto, FR | 1 |
| Cobos, EJ | 1 |
| Entrena, JM | 1 |
| Parra, A | 1 |
| García-Granados, A | 1 |
| Baeyens, JM | 1 |
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Li, Y | 1 |
| Liu, YB | 1 |
| Zhang, JJ | 1 |
| Liu, Y | 1 |
| Ma, SG | 1 |
| Qu, J | 1 |
| Lv, HN | 1 |
| Yu, SS | 1 |
| Yan, L | 1 |
| Pan, M | 1 |
| Fu, M | 1 |
| Wang, J | 4 |
| Huang, W | 3 |
| Qian, H | 2 |
| Bagal, SK | 1 |
| Andrews, M | 1 |
| Bechle, BM | 1 |
| Bian, J | 1 |
| Bilsland, J | 1 |
| Blakemore, DC | 1 |
| Braganza, JF | 1 |
| Bungay, PJ | 1 |
| Corbett, MS | 1 |
| Cronin, CN | 1 |
| Cui, JJ | 1 |
| Dias, R | 1 |
| Flanagan, NJ | 1 |
| Greasley, SE | 1 |
| Grimley, R | 1 |
| James, K | 1 |
| Johnson, E | 1 |
| Kitching, L | 1 |
| Kraus, ML | 1 |
| McAlpine, I | 1 |
| Nagata, A | 1 |
| Ninkovic, S | 1 |
| Omoto, K | 1 |
| Scales, S | 1 |
| Skerratt, SE | 1 |
| Sun, J | 1 |
| Tran-Dubé, M | 1 |
| Waldron, GJ | 1 |
| Wang, F | 1 |
| Warmus, JS | 1 |
| Shirahashi, H | 1 |
| Toriihara, E | 1 |
| Suenaga, Y | 1 |
| Yoshida, H | 1 |
| Akaogi, K | 1 |
| Endou, Y | 1 |
| Wakabayashi, M | 1 |
| Takashima, M | 1 |
| Koppitz, M | 1 |
| Bräuer, N | 1 |
| Ter Laak, A | 1 |
| Irlbacher, H | 1 |
| Rotgeri, A | 1 |
| Coelho, AM | 1 |
| Walter, D | 1 |
| Steinmeyer, A | 1 |
| Zollner, TM | 1 |
| Peters, M | 1 |
| Nagel, J | 1 |
| Bua, S | 1 |
| Lucarini, L | 1 |
| Micheli, L | 2 |
| Menicatti, M | 1 |
| Bartolucci, G | 1 |
| Selleri, S | 1 |
| Di Cesare Mannelli, L | 2 |
| Ghelardini, C | 2 |
| Masini, E | 1 |
| Carta, F | 1 |
| Gratteri, P | 1 |
| Nocentini, A | 1 |
| Supuran, CT | 1 |
| Panda, SS | 3 |
| Girgis, AS | 3 |
| Thomas, SJ | 1 |
| Capito, JE | 1 |
| George, RF | 2 |
| Salman, A | 1 |
| El-Manawaty, MA | 1 |
| Samir, A | 1 |
| Wang, Y | 1 |
| Hu, X | 1 |
| Huang, H | 1 |
| Jin, Z | 1 |
| Gao, J | 1 |
| Guo, Y | 1 |
| Zhong, Y | 1 |
| Li, Z | 1 |
| Zong, X | 1 |
| Wang, K | 1 |
| Zhang, L | 1 |
| Liu, Z | 1 |
| Pankey, AN | 1 |
| Chandar, A | 1 |
| Isaacson, G | 1 |
| Bandarkar, F | 1 |
| Masocha, W | 1 |
| Nada, A | 1 |
| Ghanim, AM | 1 |
| Kariuki, BM | 1 |
| Samir, N | 1 |
| Said, MF | 1 |
| Abdelnaser, A | 1 |
| Nasr, S | 1 |
| Bekheit, MS | 1 |
| Abdelhameed, MF | 1 |
| Almalki, AJ | 1 |
| Ibrahim, TS | 1 |
| Friedlander, EB | 1 |
| Raidoo, S | 1 |
| Soon, R | 1 |
| Salcedo, J | 1 |
| Davis, J | 1 |
| Tschann, M | 1 |
| Fontanilla, T | 1 |
| Horiuchi, W | 1 |
| Kaneshiro, B | 1 |
| Kara, A | 1 |
| Büyükcam, A | 1 |
| Sütçü, M | 1 |
| Sali, E | 1 |
| Bozdemir, ŞE | 1 |
| Kara, M | 1 |
| İlarslan, EÇ | 1 |
| Kaya, C | 1 |
| Karakaşlılar, S | 1 |
| Sönmez, G | 1 |
| Kara, SS | 1 |
| Bedir, T | 1 |
| Albayrak, E | 1 |
| Kara, TT | 1 |
| Çelebi, S | 1 |
| Öz, FN | 1 |
| Karbuz, A | 1 |
| Somer, A | 1 |
| Alabaz, D | 1 |
| Tezer, H | 1 |
| Özdemir, H | 1 |
| Çiftçi, E | 1 |
| Zhang, XY | 1 |
| Barakat, A | 1 |
| Diaz-delCastillo, M | 1 |
| Vollert, J | 1 |
| Sena, ES | 1 |
| Heegaard, AM | 1 |
| Rice, ASC | 1 |
| Soliman, N | 1 |
| Morse, JD | 1 |
| Stanescu, I | 1 |
| Atkinson, HC | 1 |
| Anderson, BJ | 1 |
| Lampert, A | 1 |
| Lange, R | 1 |
| Weiser, T | 1 |
| Reynolds-Wright, JJ | 2 |
| Woldetsadik, MA | 2 |
| Morroni, C | 2 |
| Cameron, S | 1 |
| Khalilzadeh, E | 1 |
| Mousavi, S | 1 |
| Dolatyarieslami, M | 1 |
| Bahadori, R | 1 |
| Khanna, R | 1 |
| Ziesenitz, VC | 2 |
| Welzel, T | 1 |
| van Dyk, M | 1 |
| Saur, P | 1 |
| Gorenflo, M | 1 |
| van den Anker, JN | 4 |
| Ali, S | 4 |
| Gourlay, K | 1 |
| Yukseloglu, A | 1 |
| Rosychuk, RJ | 1 |
| Ortiz, S | 1 |
| Watts, R | 1 |
| Johnson, DW | 1 |
| Carleton, B | 1 |
| Le May, S | 2 |
| Drendel, AL | 3 |
| Cameron, ST | 1 |
| Altarifi, AA | 1 |
| Younis, BA | 1 |
| Nuseir, KQ | 2 |
| Al-Mousa, AA | 1 |
| Qaoud, AK | 1 |
| Alsalem, MI | 1 |
| Neubert, JK | 1 |
| Elnaghy, AM | 3 |
| Elshazli, AH | 3 |
| Elsaka, SE | 3 |
| Jabr, L | 1 |
| Altuhafy, M | 1 |
| Barmak, AB | 1 |
| Rossouw, PE | 1 |
| Michelogiannakis, D | 1 |
| Sun, CK | 1 |
| Tsai, TH | 1 |
| Zempsky, W | 1 |
| Bell, J | 1 |
| Mossali, VM | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prophylactic Pregabalin to Decrease Pain During Medical Abortion: a Randomized Controlled Trial[NCT02782169] | Phase 4 | 110 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| PAIN CONTROL IN FIRST TRIMESTER MEDICAL ABORTION: A Randomized Trial[NCT01457521] | Phase 4 | 250 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| The Effect of Prophylactic Ibuprofen Versus Placebo on Pain Relief and Success Rates of Medical Abortion: A Double-blind Randomized Placebo Controlled Study[NCT00997074] | Phase 3 | 61 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| An Open-label, Randomized, 3-way Crossover Study to Evaluate the Pharmacokinetics of Investigational Product Ibuprofen Modified-Release Tablets 800 mg Compared to Ibuprofen Tablets 800 mg in Healthy Volunteers[NCT05329454] | Phase 1 | 30 participants (Actual) | Interventional | 2020-12-24 | Completed | ||
| Cannabinoid Analgesia for Medical Abortion: A Randomized Controlled Trial[NCT03604341] | Phase 4 | 72 participants (Actual) | Interventional | 2018-11-01 | Completed | ||
| A Study of Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries: The No OUCH Trials[NCT03767933] | Phase 2 | 710 participants (Actual) | Interventional | 2019-04-20 | Completed | ||
| An Open-label, Single-dose, Pharmacokinetic Study of Acetaminophen/Naproxen Sodium Fixed Combination Tablets in Adolescents 12 to <17 Years of Age With Orthodontic Pain[NCT05844995] | Phase 1 | 30 participants (Anticipated) | Interventional | 2023-09-13 | Recruiting | ||
| Identifying Treatment Responders to a Topical Non-steroidal Anti-inflammatory Drug (NSAID) or Topical Capsaicin in Painful Knee Osteoarthritis: A Pilot Series of N-of-1 Trials[NCT03146689] | 22 participants (Actual) | Interventional | 2017-08-04 | Completed | |||
| Cost-effectiveness Analysis of Oral Paracetamol and Ibuprofen for Treating Pain After Soft Tissue Limb Injuries: Double-blind, Randomised Controlled Trial[NCT00528658] | Phase 2 | 782 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Clinical Evaluation of the Effectiveness of Different Methods in Reducing Pain During Debonding of Orthodontic Fixed Appliance: a Randomized Clinical Trial[NCT05904587] | 128 participants (Anticipated) | Interventional | 2023-03-19 | Recruiting | |||
| Comparison of Topical 1% Diclofenac and Topical 2.5% Hydrocortisone for TMJ Arthralgia[NCT05816226] | Phase 3 | 90 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | ||
| Comparison of Serratus Plane Block With Parenteral Opioid Analgesia Versus Patient Controlled Analgesia Alone in Acute Rib fracturEs[NCT03919916] | 58 participants (Anticipated) | Interventional | 2021-05-28 | Recruiting | |||
| Assessing the Efficacy of IV Ibuprofen for Treatment of Pain in Orthopedic Trauma Patients[NCT02152163] | Phase 4 | 99 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| Percutaneous Pin Removal in the Outpatient Clinic - do Children Require Analgesia? A Randomized Controlled Trial[NCT01944085] | 240 participants (Actual) | Interventional | 2008-10-31 | Completed | |||
| Comparison of Analgesic Efficacy of Dexketoprofen and Ibuprofen in Long Bone Fractures: Randomised Controlled Double-blind Study[NCT06060236] | Phase 4 | 100 participants (Anticipated) | Interventional | 2023-09-01 | Recruiting | ||
| Oral Morphine Versus Ibuprofen for Post-fracture Pain Management in Children: a Randomized Controlled Study[NCT01690780] | 183 participants (Actual) | Interventional | 2012-09-30 | Completed | |||
| Multi-dose Ibuprofen Prophylaxis for IUD-insertion (MIPI): A Triple Blinded[NCT03868137] | 86 participants (Anticipated) | Interventional | 2020-09-28 | Recruiting | |||
| Immediate Versus Delayed IUD Insertion Following Suction Aspiration Between 5 and 12 Weeks Gestation: a Randomized Trial[NCT00562276] | Phase 4 | 578 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| Evaluation Of The Efficacy Of A Novel Ibuprofen Formulation In The Treatment Of Post-Surgical Dental Pain: Study I[NCT01098747] | Phase 3 | 335 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Evaluation Of The Efficacy Of A Novel Ibuprofen Formulation In The Treatment Of Episodic Tension-Type Headache[NCT01077973] | Phase 3 | 200 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| Evaluation Of The Efficacy Of A Novel Ibuprofen Formulation In The Treatment Of Post-Surgical Dental Pain[NCT01216163] | Phase 3 | 218 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Ibuprofen Sodium Tension Headache Study[NCT01362491] | Phase 3 | 226 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Evaluation Of The Antipyretic Efficacy Of Ibuprofen Sodium Tablets In Subjects With An Uncomplicated Acute Infection[NCT01035346] | Phase 3 | 16 participants (Actual) | Interventional | 2010-01-31 | Terminated | ||
| Pilot, Open Non-controled Trial to Assess the Feasibility of Implementing Objective Parameters as Primary Endpoints in a Clinical Trial With Patients Affected by Knee Osteoarthritis[NCT03421054] | 8 participants (Actual) | Interventional | 2018-03-19 | Completed | |||
| Double Blind, Placebo Controlled Trial to Evaluate the Effects of a Nutraceutical Containing High-Molecular-Weight Hyaluronic Acid (HA) and Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) in Patients Affected by Knee Osteoarthritis[NCT03612986] | 72 participants (Actual) | Interventional | 2018-08-22 | Completed | |||
| Lidocaine for Pain Control During Intrauterine Device Insertion: A Randomized Clinical Trial[NCT03362905] | Phase 4 | 123 participants (Anticipated) | Interventional | 2017-12-03 | Not yet recruiting | ||
| Does LI4 Acupuncture Provide an Effective Analgesia During Intrauterine Device[NCT04963582] | 72 participants (Actual) | Interventional | 2021-07-05 | Completed | |||
| Effect of Adding Vaginal Isosorbide Mononitrate to Misoprostol Prior to Intrauterine Device Insertion in Women Delivered Only by Elective Cesarean Section: a Randomized Double-blind Controlled Clinical Trial[NCT03587077] | 113 participants (Anticipated) | Interventional | 2018-09-30 | Not yet recruiting | |||
| Comparison of the Effects of Ibuprofen and Low-Level Laser Therapy on Orthodontic Pain By Means of Interleukin 1-Beta and Substance P Levels in the Gingival Crevicular Fluid[NCT04070001] | 60 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| Efficacy of Pain Control Following Root Canal Treatment Using Paracetamol Alone and in Combination With Three Different Non-Steroidal Anti-Inflammatory Analgesics[NCT02417337] | Phase 2 | 170 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| Effect of Preoperative, Single-dose Diclofenac Potassium on Postoperative Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Double Blind Randomized Controlled Trial[NCT03341260] | Phase 2/Phase 3 | 70 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| The Copenhagen Analgesic Study[NCT04369222] | 600 participants (Anticipated) | Observational | 2020-03-01 | Recruiting | |||
| An Evaluation of the Effectiveness of Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease: a Double-blind, Placebo-controlled Randomised Trial[NCT00880373] | Phase 4 | 320 participants (Anticipated) | Interventional | 2011-03-31 | Terminated (stopped due to The funding withdrawal and early termination of the trial is based upon lack of suitable recruitment figures in order to reach the required trial endpoints.) | ||
| Childrens' Experiences of Pain in Conjunction With Tooth Extraction - a Grounded Theory[NCT04064853] | 12 participants (Actual) | Observational | 2019-04-05 | Completed | |||
| Comparison of Pre-emptive Ibuprofen, Acetaminophen, and Placebo Administration in Reducing Local Anesthesia Injection Pain and Post-operative Pain in Primary Tooth Extraction. A Clinical Study[NCT03786029] | Phase 2/Phase 3 | 66 participants (Actual) | Interventional | 2019-04-01 | Completed | ||
| Effect of Preoperative Administration of Ibuprofen in Children Undergoing Extraction for Reducing Postoperative Pain: A Double-blind Randomized Controlled Clinical Trial[NCT04476069] | Phase 3 | 56 participants (Actual) | Interventional | 2019-01-10 | Completed | ||
| Acetaminophen vs. Ibuprofen in Children With Asthma[NCT01606319] | Phase 3 | 300 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| A Study of the Efficacy and Tolerability of Once Daily Celebrex (Celecoxib) and Three Times Daily Ibuprofen vs. Placebo in the Treatment of Subjects With Osteoarthritis of the Knee[NCT00630929] | Phase 4 | 388 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Anti TNFa Treatment for Deep Endometriosis Associated Pain : a Randomised Placebo Controlled Trial.[NCT00604864] | Phase 2 | 20 participants (Actual) | Interventional | 2004-02-29 | Completed | ||
| The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electromyography in Pediatric Population-A Randomized Controlled Trial[NCT04337814] | 113 participants (Actual) | Interventional | 2019-12-30 | Completed | |||
| Postoperative Effects of Chewing Gum, Ibuprofen and Acetaminophen on Pain After Initial Archwire Placement: a Randomized Controlled Trial[NCT03568721] | Phase 4 | 81 participants (Actual) | Interventional | 2015-01-25 | Completed | ||
| The Effect of the Chewing Gum in Alleviating Orthodontic Pain After Separator and Initial Arch Wire Placement: A Randomized Clinical Trial[NCT04836234] | 108 participants (Anticipated) | Interventional | 2019-03-06 | Recruiting | |||
| Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain of Initial Orthodontic Wire Insertion: a Randomized Controlled Trial[NCT04059172] | Early Phase 1 | 375 participants (Anticipated) | Interventional | 2019-12-10 | Recruiting | ||
| Pain Control for Intrauterine Device Placement: A Randomized, Double Blind Control Trial of Ketorolac Prior to Intrauterine Device Placement.[NCT01664559] | 67 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| Postplacental Intrauterine Device Insertion: A Mixed Methods Assessment of Women's Experience[NCT02312726] | 135 participants (Actual) | Observational | 2013-11-30 | Completed | |||
| Pain Control for Intrauterine Device Placement: A Randomized Controlled Trial of Paracervical Block[NCT02219308] | 67 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| Nitrous Oxide for Pain Management of Intrauterine Device Insertion[NCT02391714] | 80 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| Randomized Controlled Trial of Cervical Lidocaine for Intrauterine Device Insertion Pain[NCT01411995] | 200 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Study of Pain Control With Hormonal IUS Insertion (SOPHI Study)[NCT02352714] | Phase 4 | 98 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Impact of the Combined Treatment of Curcumin and Resveratrol Liposomed Polyphenols With G04CB02 on the Clinical Improvement of ALS Patients[NCT04654689] | Phase 2 | 90 participants (Actual) | Interventional | 2021-11-20 | Completed | ||
| Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis[NCT00833157] | Phase 1 | 36 participants (Actual) | Interventional | 2005-02-28 | Active, not recruiting | ||
| A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy[NCT01267136] | Phase 4 | 84 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Ibuprofen vs. Codeine. Is One Better for Post-operative Pain Relief Following Reduction of Paediatric Forearm Fractures?[NCT01605240] | 50 participants (Anticipated) | Interventional | 2012-07-31 | Recruiting | |||
| "Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623] | 300 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| A Randomized Clinical Trial of Buzzy Versus Vapocoolant in Pain Relief During Phlebotomy and IV Catheterization in the Pediatric ED[NCT06182631] | Phase 3 | 176 participants (Actual) | Interventional | 2019-07-15 | Completed | ||
| Paracervical Block for Pain Control During Osmotic Dilator Placement: a Randomized Controlled Trial[NCT02354092] | 14 participants (Actual) | Interventional | 2015-04-02 | Terminated | |||
| Paracervical Block With Ketorolac and Lidocaine in First Trimester Surgical Abortions[NCT00617097] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy[NCT03385057] | Phase 1 | 0 participants (Actual) | Interventional | 2018-09-30 | Withdrawn (stopped due to Study design flaws; research design needed to be reconfigured) | ||
| The Effect of Electroacupuncture (EA) on the Success of Inferior Alveolar Nerve Block (IANB) and Post-operative Pain Relief in Mandibular Molar With Symptomatic Irreversible Pulpitis (SIP) Among Malaysians: A Study Protocol for Randomized Double-Blinded C[NCT04804761] | 20 participants (Anticipated) | Interventional | 2023-01-01 | Recruiting | |||
| Placebo-controlled, Dose-response Study of Ibuprofen Effects on Brain Function[NCT02507219] | Phase 2/Phase 3 | 24 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Assessment of Low-level Laser Therapy Versus Paracetamol-caffeine Efficacy in Controlling Pain During Fixed Orthodontic Treatment and Their Role in Enhancing Oral-health-related Quality of Life: A Randomized Controlled Trial[NCT03400111] | 60 participants (Actual) | Interventional | 2017-09-15 | Completed | |||
| Assessment of the Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic[NCT02268955] | 22 participants (Actual) | Interventional | 2014-09-09 | Completed | |||
| Management of Superficial Thrombophlebitis[NCT00264381] | Phase 4 | 72 participants (Actual) | Interventional | 2002-10-31 | Completed | ||
| A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755] | 62 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| Double-blind Randomized Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo, in the Outpatients Area.[NCT03676556] | Phase 3 | 46 participants (Anticipated) | Interventional | 2021-06-16 | Recruiting | ||
| Randomised, Double-blind Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo[NCT02584335] | Phase 4 | 7 participants (Actual) | Interventional | 2015-07-31 | Terminated (stopped due to Difficulties with the recruitment) | ||
| A Randomised, Double-blind, Double-dummy, Parallel-group, Single Dose, Active and Placebo-controlled Efficacy and Pharmacokinetics/Pharmacodynamics Study of 2 x 200 mg Ibuprofen Liquid Capsules for the Treatment of Pain After Surgical Removal of Impacted [NCT05484401] | Phase 3 | 294 participants (Actual) | Interventional | 2022-08-09 | Completed | ||
| A Randomized, Crossover, Pilot Trial of the Feasibility and Safety of Acupoint Injection of Vitamin K for Treatment of Primary Dysmenorrhea[NCT00995917] | 18 participants (Actual) | Interventional | 2009-10-31 | Completed | |||
| Comparison of the Efficacy of Topical Ibuprofen to Oral Ibuprofen in Adolescent Athletes[NCT00567528] | 60 participants (Actual) | Interventional | 2006-05-31 | Terminated (stopped due to Study was not producing meaningful data.) | |||
| A Multicentre Randomised Placebo-Controlled Trail of Ibuprofen for the Prevention of Ectopic Bone-Related Pain and Disability After Elective Hip Replacement Surgery (HIPAID)[NCT00145730] | Phase 4 | 1,000 participants | Interventional | 2002-02-28 | Completed | ||
| A Trial of Prednisone and Acetaminophen Versus Acetaminophen Alone in Minimizing Flu-like Symptoms From Pegylated Interferon Beta-1a[NCT03424733] | Phase 4 | 50 participants (Anticipated) | Interventional | 2017-09-25 | Recruiting | ||
| Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain[NCT05311774] | 400 participants (Anticipated) | Interventional | 2022-04-30 | Not yet recruiting | |||
| Analgesia Efficacy of Pre-operative and Post-operative PEC I/II Block for Bilateral Mastectomy With Reconstruction[NCT03653988] | 35 participants (Actual) | Interventional | 2019-03-12 | Completed | |||
| Comparison Between Serratus Anterior Plane Block, and Transversus Thoracic Plane Block Combined With Serratus Anterior Plane Block, for the Management of Post-mastecomy Pain.[NCT04375111] | 54 participants (Actual) | Interventional | 2021-06-15 | Completed | |||
| Phase III Clinical Trial Studying Analgesic Efficacy of Morphine Alone or Combined With Paracetamol and/or Ibuprofen for Long-bones Fractures in Children[NCT02477007] | Phase 3 | 304 participants (Actual) | Interventional | 2015-12-03 | Completed | ||
| Acute Kidney Injury and Nonsteroidal Anti-inflammatory Drugs in Patients Undergoing High-risk Abdominal or Thoracic Surgery[NCT02553174] | 50 participants (Actual) | Observational | 2016-06-01 | Terminated (stopped due to unable to recruit sufficient patients to satisfy study protocols) | |||
| Effective Analgesia Using the 5 S's During Routine Immunizations at 2 and 4 Months[NCT01368861] | 230 participants (Actual) | Observational | 2010-06-30 | Completed | |||
| Childhood Immunization: Reducing Immunization Distress (RID) Using Multi-Modal Distraction[NCT01379885] | 77 participants (Actual) | Interventional | 2011-06-30 | Terminated (stopped due to Estimated sample size not achieved due to decline in number of eligible patients and difficulty recruiting and retaining research staff.) | |||
| An Evaluation of Hydrocodone/Acetaminophen for Pain Control in First Trimester Surgical Abortion[NCT01330459] | Phase 4 | 121 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| Ibuprofen Supplementation After Resistance Training and Its Effects on Bone in Older Women[NCT01886196] | 90 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| An Evaluation of the Paracervical Block for Pain Control in First Trimester Surgical Abortion[NCT01094366] | Phase 4 | 121 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Buffered Lidocaine for Paracervical Block to Decrease Injection Pain During First Trimester Uterine Aspirations[NCT03107754] | Phase 4 | 98 participants (Actual) | Interventional | 2017-05-15 | Completed | ||
| A Randomized Double-blinded Trial Comparing the Clinical Efficacy and Pharmacokinetic Parameters of Oral Diclofenac and Intramuscular Diclofenac in Patients With Acute Limb Injuries[NCT03472339] | Phase 4 | 300 participants (Anticipated) | Interventional | 2018-01-15 | Recruiting | ||
| Hypoalgesic Effect of Median Nerve Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group[NCT02596815] | 51 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Hypoalgesic Effect of Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group[NCT02595294] | 52 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Randomized Double Blind Clinical Trial on the Effect of Levobupivacaine Infiltration Versus Placebo on the Post Partum Perineal Pain in Episiotomy in Primiparous Women After Instrumental Delivery[NCT02796547] | Phase 2 | 0 participants (Actual) | Interventional | 2016-07-14 | Withdrawn (stopped due to Lack of human ressources) | ||
| [NCT00005192] | 0 participants | Observational | 1986-07-31 | Completed | |||
| [NCT00005231] | 0 participants | Observational | 1988-07-31 | Completed | |||
| Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722772] | 60 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| Efficacy of Subcutaneous Injection of Etanercept for Moderate and Severe Knee Osteoarthritis[NCT02722811] | 60 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| Comparison of the Effects of Instrumental Assisted Soft Tissue Mobilization and Foam Roller on Delayed Muscle Pain.[NCT05328830] | 42 participants (Actual) | Interventional | 2022-01-04 | Completed | |||
| Inhaled Glucocorticoids for Acute Pharyngitis: A Randomized Clinical Trial[NCT04027322] | Phase 2/Phase 3 | 200 participants (Actual) | Interventional | 2019-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
reported on an 11-point numerical rating scale (NRS 0-10) where 0 indicates no pain and 10 indicates the most severe pain (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)
| Intervention | units on a scale (Mean) |
|---|---|
| Pregabalin | 5.0 |
| Placebo | 5.5 |
summed number of tablets used by each participant over the 72 hour study period (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)
| Intervention | tablets (Median) |
|---|---|
| Pregabalin | 1 |
| Placebo | 2 |
summed number of tablets used by each participant over the 72 hour study period (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)
| Intervention | tablets (Median) |
|---|---|
| Pregabalin | 0 |
| Placebo | 0.5 |
A participant was included once if they ever reported a symptom during the 72 hour study period, not reflective of how long the symptom lasted. These were all commonly reported side effects during previous research on medication abortions and commonly reported side effects of pregabalin, so they were not included as adverse events. (NCT02782169)
Timeframe: Over 72 hours (measured at 0, 2, 6, 12, 24, and 72 hours)
| Intervention | participants (Number) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Nausea | Vomiting | Sleepiness | Dizziness | Headache | Blurred Vision | Diarrhea | Constipation | Dry Mouth | |
| Placebo | 42 | 30 | 39 | 26 | 17 | 7 | 29 | 15 | 25 |
| Pregabalin | 43 | 28 | 47 | 45 | 28 | 15 | 28 | 6 | 22 |
Participant pain was assessed using an 11-point Visual Analog Scale for Pain. Scores ranged from 0 (no pain) to 10 (worst pain possible) (NCT01457521)
Timeframe: 1-2 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Prophylactic | 7.1 |
| Therapeutic | 7.3 |
Women will text responds to surveys within 24 hours after misoprostol administration indicating their maximum self-reported pain using an 11-point numeric rating scale (NRS 0-10) where 0=no pain and 10=worst possible pain. (NCT03604341)
Timeframe: 24 hours after misoprostol administration
| Intervention | score on a scale (Median) |
|---|---|
| Gestational Age up to 10w0d - Dronabinol | 7 |
| Gestational Age up to 10w0d - Placebo | 7 |
Outcome measure based on morphine equivalent dosage comparing the two groups (NCT02152163)
Timeframe: morphine equivalent dosage in over 48 hours after admission
| Intervention | morphine equivalent dosage, mg (Least Squares Mean) |
|---|---|
| IV Ibuprofen 800 mg | 74.9 |
| IV Saline | 97.8 |
Participant global evaluation of study medication was performed at the 8-hour time point or immediately before taking the rescue medication. It was scored on a 6-point categorical scale where 0 = Very poor, 1 = Poor, 2 = Fair, 3 = Good, 4 = Very Good, and 5 = Excellent. (NCT01098747)
Timeframe: 8 hours
| Intervention | Units on a scale (Mean) |
|---|---|
| Placebo | 1.1 |
| Ibuprofen Sodium | 3.8 |
| Ibuprofen (Advil + Motrin IB) | 3.7 |
Participants evaluated the time to first perceptible relief by stopping a stopwatch labeled 'first perceptible relief' at the moment they first began to experience any relief. Stopwatch was active up to 8 hours after dosing or until stopped by the participant, or rescue medication was administered. The first perceptible relief was considered confirmed if the participant also stopped the second stopwatch indicating meaningful relief. (NCT01098747)
Timeframe: 0 to 8 hours
| Intervention | Minutes (Median) |
|---|---|
| Placebo | NA |
| Ibuprofen Sodium | 16.4 |
| Ibuprofen (Advil + Motrin IB) | 25.7 |
Participants evaluated the time to meaningful relief by stopping a second stopwatch labeled 'meaningful relief' at the moment they first began to experience meaningful relief. Stopwatch was active up to 8 hours after dosing or until stopped by the participant, or rescue medication was administered. (NCT01098747)
Timeframe: 0 to 8 hours
| Intervention | Minutes (Median) |
|---|---|
| Placebo | NA |
| Ibuprofen Sodium | 42.4 |
| Ibuprofen (Advil + Motrin IB) | 55.3 |
Median time of dropping out of the participants from the study due to lack of efficacy or rescue medication, whichever came first. (NCT01098747)
Timeframe: 0 to 8 hours
| Intervention | Hours (Median) |
|---|---|
| Placebo | 1.7 |
| Ibuprofen Sodium | NA |
| Ibuprofen (Advil + Motrin IB) | NA |
SPRID: time-weighted sum of pain relief rating combined with pain intensity difference (PRID) over 8 hours. SPRID 0-8 score range: -8 (worst) to 56 (best). PRID: sum of Pain intensity differences (PID) and pain relief rating (PRR) at each time point. PRID score range: -1=worst to 7=best. PID: baseline pain severity score minus pain severity score at a given time point (pain severity score range 0=none to 3=severe; baseline score range 2=moderate to 3=severe). PID score range: -1(worst) to 3 (best). PRR: assessed on 5-point pain relief rating scale (0=No relief to 4=Complete relief). (NCT01098747)
Timeframe: 0 to 8 hours
| Intervention | Units on a scale (Mean) |
|---|---|
| Placebo | 5.4 |
| Ibuprofen Sodium | 29.8 |
Complete relief was defined as a PRR of 4. PRR was assessed on a 5-point categorical pain relief rating scale where 0=No relief to 4=Complete relief. (NCT01098747)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8 hours
| Intervention | Percentage of participants (Number) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | 7 hours | 8 hours | |
| Ibuprofen (Advil + Motrin IB) | 0.0 | 3.5 | 20.8 | 32.4 | 43.9 | 54.9 | 61.8 | 63.0 | 63.6 | 64.2 | 64.2 |
| Ibuprofen Sodium | 0.0 | 6.3 | 27.4 | 41.1 | 48.4 | 52.6 | 54.7 | 54.7 | 54.7 | 54.7 | 54.7 |
| Placebo | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 6.3 | 6.3 | 6.3 | 6.3 | 6.3 |
Percentage of participants with first perceptible relief was evaluated by stopping a stopwatch labeled 'first perceptible relief' at the moment the participant first began to experience any relief. Stopwatch was active up to 8 hours after dosing or until stopped by the participant, or rescue medication was administered. The first perceptible relief was considered confirmed if the participant also stopped the second stopwatch indicating meaningful relief. (NCT01098747)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8 hours
| Intervention | Percentage of participants (Number) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | 7 hours | 8 hours | |
| Ibuprofen (Advil + Motrin IB) | 12.1 | 60.7 | 84.4 | 87.3 | 87.9 | 88.4 | 88.4 | 88.4 | 88.4 | 88.4 | 88.4 |
| Ibuprofen Sodium | 26.3 | 84.2 | 94.7 | 95.8 | 95.8 | 95.8 | 95.8 | 95.8 | 95.8 | 95.8 | 95.8 |
| Placebo | 6.3 | 14.6 | 20.8 | 22.9 | 22.9 | 22.9 | 22.9 | 22.9 | 22.9 | 22.9 | 22.9 |
Percentage of participants with meaningful relief evaluated by stopping the stopwatch labeled 'meaningful relief' at the moment the participant first began to experience meaningful relief. Stopwatch was active up to 8 hours after dosing or until stopped by the participant, or rescue medication was administered. (NCT01098747)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8 hours
| Intervention | Percentage of participants (Number) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | 7 hours | 8 hours | |
| Ibuprofen (Advil + Motrin IB) | 0.6 | 16.8 | 52.6 | 69.9 | 79.8 | 86.7 | 87.9 | 87.9 | 87.9 | 87.9 | 88.4 |
| Ibuprofen Sodium | 1.1 | 28.4 | 73.7 | 87.4 | 91.6 | 94.7 | 94.7 | 94.7 | 94.7 | 95.8 | 95.8 |
| Placebo | 0.0 | 4.2 | 12.5 | 14.6 | 18.8 | 20.8 | 20.8 | 20.8 | 20.8 | 20.8 | 22.9 |
Percentage of participants who withdrew from the study due to lack of efficacy or received rescue medication. (NCT01098747)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8 hours
| Intervention | Percentage of participants (Number) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | 7 hours | 8 hours | |
| Ibuprofen (Advil + Motrin IB) | 0.0 | 0.0 | 0.0 | 2.3 | 5.8 | 8.1 | 8.1 | 10.4 | 12.1 | 16.2 | 20.2 |
| Ibuprofen Sodium | 0.0 | 0.0 | 0.0 | 1.1 | 2.1 | 4.2 | 9.5 | 10.5 | 13.7 | 20.0 | 26.3 |
| Placebo | 0.0 | 0.0 | 0.0 | 25.0 | 54.2 | 70.8 | 70.8 | 70.8 | 72.9 | 77.1 | 79.2 |
PID was derived by subtracting the pain severity score at a given post-dosing time point (pain severity score range 0 [none] to 3 [severe]) from the baseline score (Baseline pain severity score range 2 [moderate] to 3 [severe]). Total possible score range for PID: -1 (worst) to 3 (best). (NCT01098747)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8 hours
| Intervention | Units on a scale (Mean) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hour | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | 7 hours | 8 hours | |
| Ibuprofen (Advil + Motrin IB) | 0.1 | 0.6 | 1.3 | 1.5 | 1.7 | 1.7 | 1.7 | 1.6 | 1.5 | 1.2 | 1.1 |
| Ibuprofen Sodium | 0.3 | 1.0 | 1.5 | 1.7 | 1.8 | 1.6 | 1.5 | 1.4 | 1.2 | 0.9 | 0.8 |
| Placebo | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | -0.0 | -0.0 | -0.0 |
PRR was evaluated at different time points during the study up to 8 hours after taking the study medication, and immediately before rescue medication was taken (if necessary). PRR was assessed on a 5-point categorical pain relief rating scale where 0=No relief to 4=Complete relief. (NCT01098747)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8 hours
| Intervention | Units on a scale (Mean) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | 7 hours | 8 hours | |
| Ibuprofen (Advil + Motrin IB) | 0.5 | 1.5 | 2.5 | 2.8 | 3.0 | 3.0 | 3.0 | 2.8 | 2.6 | 2.3 | 2.2 |
| Ibuprofen Sodium | 0.7 | 2.0 | 2.9 | 3.1 | 3.1 | 2.9 | 2.8 | 2.6 | 2.3 | 1.9 | 1.7 |
| Placebo | 0.4 | 0.5 | 0.6 | 0.7 | 0.7 | 0.7 | 0.8 | 0.7 | 0.7 | 0.5 | 0.5 |
PRID was sum of PID and PRR at each post-dosing time point. The overall possible score range, for PRID was -1 (worst) to 7 (best). PID was derived by subtracting the pain severity score at a given post-dosing time point (pain severity score range 0 [none] to 3 [severe]) from the baseline score (Baseline pain severity score range 2 [moderate] to 3 [severe]). Total possible score range for PID: -1 (worst) to 3 (best). PRR was assessed on 5-point categorical pain relief rating scale (0=No relief to 4=Complete relief). (NCT01098747)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8 hours
| Intervention | Units on a scale (Mean) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | 7 hours | 8 hours | |
| Ibuprofen (Advil + Motrin IB) | 0.6 | 2.1 | 3.8 | 4.3 | 4.7 | 4.7 | 4.8 | 4.4 | 4.1 | 3.5 | 3.2 |
| Ibuprofen Sodium | 1.1 | 3.0 | 4.4 | 4.8 | 4.9 | 4.5 | 4.3 | 4.0 | 3.5 | 2.9 | 2.6 |
| Placebo | 0.4 | 0.6 | 0.7 | 0.7 | 0.8 | 0.7 | 0.9 | 0.8 | 0.6 | 0.5 | 0.5 |
SPID: time-weighted sum of PID over 2, 3, 6 and 8 hours. SPID scores range was -2 (worst) to 6 (best) for SPID 0-2, -3 (worst) to 9 (best) for SPID 0-3, -6 (worst) to 18 (best) for SPID 0-6, -8 (worst) to 24 (best) for SPID 0-8. PID: baseline pain severity score minus pain severity score at a given time point (pain severity score range 0=none to 3=severe; baseline score range 2=moderate to 3=severe). Total score range for PID: -1(worst) to 3 (best). (NCT01098747)
Timeframe: 0-2, 0-3, 0-6, 0-8 hours
| Intervention | Units on a scale (Mean) | |||
|---|---|---|---|---|
| SPID 0-2 | SPID 0-3 | SPID 0-6 | SPID 0-8 | |
| Ibuprofen (Advil + Motrin IB) | 2.4 | 4.1 | 8.9 | 11.1 |
| Ibuprofen Sodium | 2.8 | 4.4 | 8.5 | 10.2 |
| Placebo | 0.1 | 0.1 | 0.2 | 0.1 |
TOTPAR: time-weighted sum of PRR scores over 2, 3, 6 and 8 hours. TOTPAR score range was 0 (worst) to 8 (best) for TOTPAR 0-2, 0 (worst) to 12 (best) for TOTPAR 0-3, 0 (worst) to 24 (best) for TOTPAR 0-6, 0 (worst) to 32 (best) for TOTPAR 0-8. PRR was evaluated at different time points during the study up to 8 hours, and immediately after taking rescue medication (if necessary). PRR was assessed on a 5-point categorical pain relief rating scale wherein 0=No relief to 4=Complete relief. (NCT01098747)
Timeframe: 0-2, 0-3, 0-6, 0-8 hours
| Intervention | Units on a scale (Mean) | |||
|---|---|---|---|---|
| TOTPAR 0-2 | TOTPAR 0-3 | TOTPAR 0-6 | TOTPAR 0-8 | |
| Ibuprofen (Advil + Motrin IB) | 4.6 | 7.6 | 16.1 | 20.6 |
| Ibuprofen Sodium | 5.2 | 8.1 | 15.9 | 19.5 |
| Placebo | 1.3 | 2.0 | 4.2 | 5.2 |
SPRID: time-weighted sum of PRID over 2, 3, 6 and 8 hours. SPRID score range:-2 (worst) to 14(best) for SPRID 0-2, -3(worst) to 21(best) for SPRID 0-3, -6(worst) to 42(best) for SPRID 0-6, -8(worst) to 56(best) for SPRID 0-8. PRID:sum of PID and PRR at each time point. Total score range for PRID: -1=worst to 7=best. PID:baseline pain severity score minus pain severity score at given time(score range 0=none to 3=severe; baseline score range 2=moderate to 3=severe). Total score range for PID: -1(worst) to 3(best), PRR: scored on 5-point pain relief rating scale(0=No relief to 4=Complete relief). (NCT01098747)
Timeframe: 0-2, 0-3, 0-6, 0-8 hours
| Intervention | Units on a scale (Mean) | |||
|---|---|---|---|---|
| SPRID 0-2 | SPRID 0-3 | SPRID 0-6 | SPRID 0-8 | |
| Ibuprofen (Advil + Motrin IB) | 7.0 | 11.8 | 25.0 | 31.7 |
| Ibuprofen Sodium | 8.0 | 12.6 | 24.3 | 29.8 |
| Placebo | 1.3 | 2.1 | 4.4 | 5.4 |
"Participants evaluated the time to first perceptible relief by stopping a stopwatch labeled 'first perceptible relief' at the moment the participant first began to experience any relief. Stopwatch was active up to 3 hours after dosing or until stopped by the participant, or rescue medication was administered. First perceptible relief was considered confirmed by meaningful relief if the participant achieved both first perceptible and meaningful relief by either depressing the second stopwatch or by indicating that his/her first perceptible relief was also meaningful." (NCT01077973)
Timeframe: 0 to 3 hours
| Intervention | Minutes (Median) |
|---|---|
| Placebo | 42.3 |
| Ibuprofen Sodium | 41.7 |
| Ibuprofen (Motrin IB) | 43.8 |
"Participants evaluated the time to meaningful relief by stopping a second stopwatch labeled 'meaningful relief' at the moment the participant first began to experience meaningful relief. It was also considered achieved if the participant stated meaningful relief at the time the first stopwatch was depressed. Stopwatch was active up to 3 hours after dosing or until stopped by the participant, or rescue medication was administered." (NCT01077973)
Timeframe: 0 to 3 hours
| Intervention | Minutes (Median) |
|---|---|
| Ibuprofen Sodium | 50.3 |
| Ibuprofen (Motrin IB) | 55.5 |
"Participants evaluated the time to meaningful relief by stopping a second stopwatch labeled 'meaningful relief' at the moment the participant first began to experience meaningful relief. It was also considered achieved if the participant stated meaningful relief at the time the first stopwatch was depressed. Stopwatch was active up to 3 hours after dosing or until stopped by the participant, or rescue medication was administered." (NCT01077973)
Timeframe: 0 to 3 hours
| Intervention | Minutes (Median) |
|---|---|
| Placebo | 48.2 |
| Ibuprofen Sodium | 50.3 |
| Ibuprofen (Motrin IB) | 55.5 |
SPRID:time-weighted sum of pain relief rating combined with pain intensity difference (PRID) over 3 hours. SPRID score range:-3 (worst) to 21 (best) for SPRID 0-3. PRID: sum of pain intensity differences (PID) and pain relief rating(PRR) at each time point. PRID score range: -1=worst to 7=best. PID: baseline pain severity score minus pain severity score at a given time point (score range 0=none to 3=severe; baseline score range 2=moderately severe to 3=severe). Total score range for PID: -1(worst) to 3 (best). PRR:assessed on 5-point pain relief rating scale (0=No relief to 4=Complete relief). (NCT01077973)
Timeframe: 0 to 3 hours
| Intervention | Units on a scale (Mean) |
|---|---|
| Placebo | 11.2 |
| Ibuprofen Sodium | 10.8 |
Complete relief was defined as a PRR of 4. PRR was assessed on a 5-point categorical pain relief rating scale where 0=No relief to 4=Complete relief. (NCT01077973)
Timeframe: 1, 2, 3 hours
| Intervention | Percentage of participants (Number) | ||
|---|---|---|---|
| 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 1.3 | 15.0 | 35.0 |
| Ibuprofen Sodium | 6.3 | 21.5 | 40.5 |
| Placebo | 2.4 | 17.1 | 41.5 |
"Percentage of participants with first perceptible relief evaluated by stopping a stopwatch labeled 'first perceptible relief' at the moment the participant first began to experience any relief. Stopwatch was active up to 3 hours after dosing or until stopped by the participant, or rescue medication was administered. First perceptible relief was considered confirmed by meaningful relief if the participant achieved both first perceptible and meaningful relief by either depressing the second stopwatch or by indicating that his/her first perceptible relief was also meaningful." (NCT01077973)
Timeframe: 0.5, 1, 2, 3 hours
| Intervention | Percentage of participants (Number) | |||
|---|---|---|---|---|
| 0.5 hours | 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 28.8 | 72.5 | 82.5 | 82.5 |
| Ibuprofen Sodium | 30.4 | 67.1 | 81.0 | 81.0 |
| Placebo | 24.4 | 80.5 | 85.4 | 85.4 |
"Percentage of participants with meaningful relief evaluated by stopping a second stopwatch labeled 'meaningful relief' at the moment the participant first began to experience meaningful relief. It was also considered achieved if the participant stated meaningful relief at the time the first stopwatch was depressed. Stopwatch was active up to 3 hours after dosing or until stopped by the participant, or rescue medication was administered." (NCT01077973)
Timeframe: 0.5, 1, 2, 3 hours
| Intervention | Percentage of participants (Number) | |||
|---|---|---|---|---|
| 0.5 hours | 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 10.0 | 60.0 | 81.3 | 82.5 |
| Ibuprofen Sodium | 17.7 | 58.2 | 79.7 | 81.0 |
| Placebo | 14.6 | 65.9 | 85.4 | 85.4 |
PID was derived by subtracting the pain severity score at a given post-dosing time point [pain severity score range 0 (none) to 3 (severe)] from the baseline score [Baseline pain severity score range 2 (moderately severe) to 3 (severe)]. Total possible score range for PID: -1 (worst) to 3 (best). (NCT01077973)
Timeframe: 1, 2, 3 hours
| Intervention | Units on a scale (Mean) | ||
|---|---|---|---|
| 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 0.8 | 1.2 | 1.4 |
| Ibuprofen Sodium | 0.9 | 1.3 | 1.5 |
| Placebo | 0.9 | 1.3 | 1.5 |
PRR was assessed on a 5-point categorical pain relief rating scale wherein 0=No relief to 4=Complete relief. (NCT01077973)
Timeframe: 1, 2, 3 hours
| Intervention | Units on a scale (Mean) | ||
|---|---|---|---|
| 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 1.6 | 2.4 | 2.7 |
| Ibuprofen Sodium | 1.9 | 2.5 | 2.8 |
| Placebo | 1.9 | 2.6 | 3.0 |
PRID was sum of PID and PRR at each post-dosing time point. The overall possible score range, for PRID was -1 (worst) to 7 (best). PID was derived by subtracting the pain severity score at a given post-dosing time point [pain severity score range 0 (none) to 3 (severe)] from the baseline score [Baseline pain severity score range 2 (moderately severe) to 3 (severe)]. Total possible score range for PID: -1 (worst) to 3 (best). PRR was assessed on 5-point categorical pain relief rating scale (0=No relief to 4=Complete relief). (NCT01077973)
Timeframe: 1, 2, 3 hours
| Intervention | Units on a scale (Mean) | ||
|---|---|---|---|
| 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 2.4 | 3.6 | 4.1 |
| Ibuprofen Sodium | 2.8 | 3.7 | 4.3 |
| Placebo | 2.8 | 3.9 | 4.5 |
SPID: time-weighted sum of PID over 2 and 3 hours. SPID score range was -2(worst) to 6 (best) for SPID 0-2 and -3 (worst) to 9 (best) for SPID 0-3. PID: baseline pain severity score minus pain severity score at a given time point (score range 0=none to 3=severe; baseline score range 2=moderately severe to 3=severe). Total score range for PID: -1(worst) to 3 (best). (NCT01077973)
Timeframe: 0 to 2, 0 to 3 hours
| Intervention | Units on a scale (Mean) | |
|---|---|---|
| SPID 0-2 | SPID 0-3 | |
| Ibuprofen (Motrin IB) | 2.0 | 3.4 |
| Ibuprofen Sodium | 2.2 | 3.6 |
| Placebo | 2.2 | 3.8 |
TOTPAR: time-weighted sum of PRR over 2 and 3 hours. TOTPAR score range was 0 (worst) to 8 (best) for TOTPAR 0-2 and 0 (worst) to 12 (best) for TOTPAR 0-3. PRR was assessed on a 5-point categorical pain relief rating scale wherein 0=No relief to 4=Complete relief. (NCT01077973)
Timeframe: 0 to 2, 0 to 3 hours
| Intervention | Units on a scale (Mean) | |
|---|---|---|
| TOTPAR 0-2 | TOTPAR 0-3 | |
| Ibuprofen (Motrin IB) | 4.1 | 6.8 |
| Ibuprofen Sodium | 4.4 | 7.2 |
| Placebo | 4.5 | 7.5 |
SPRID: time-weighted sum of PRID over 2 and 3 hours. SPRID score range was -2(worst) to 14(best) for SPRID 0-2 and -3 (worst) to 21 (best) for SPRID 0-3. PRID: sum of PID and PRR at each time point. Total score range for PRID: -1=worst to 7=best. PID: baseline pain severity score minus pain severity score at a given time point (score range 0=none to 3=severe; baseline score range 2=moderately severe to 3=severe). Total score range for PID: -1(worst) to 3(best), PRR: assessed on 5-point pain relief rating scale (0=No relief to 4=Complete relief). (NCT01077973)
Timeframe: 0 to 2, 0 to 3 hours
| Intervention | Units on a scale (Mean) | |
|---|---|---|
| SPRID 0-2 | SPRID 0-3 | |
| Ibuprofen (Motrin IB) | 6.1 | 10.2 |
| Ibuprofen Sodium | 6.5 | 10.8 |
| Placebo | 6.7 | 11.2 |
Participant global evaluation of study medication was performed at the 6-hour time point or immediately before taking the rescue medication. It was scored on a 6-point categorical scale where 0 = Very poor, 1 = Poor, 2 = Fair, 3 = Good, 4 = Very Good, and 5 = Excellent. (NCT01216163)
Timeframe: 6 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 0.9 |
| Ibuprofen Sodium | 3.5 |
| Acetaminophen | 3.0 |
Participants evaluated the time to first perceptible relief by stopping a stopwatch labeled 'first perceptible relief' at the moment they first began to experience any relief. Stopwatch was active up to 6 hours after dosing or until stopped by the participant, or rescue medication was administered. The first perceptible relief was considered confirmed if the participant also stopped the second stopwatch indicating meaningful relief. (NCT01216163)
Timeframe: 0 to 6 hours
| Intervention | minutes (Median) |
|---|---|
| Placebo | NA |
| Ibuprofen Sodium | 16.0 |
| Acetaminophen | 23.7 |
Participants evaluated the time to meaningful relief by stopping a second stopwatch labeled 'meaningful relief' at the moment they first began to experience meaningful relief. Stopwatch was active up to 6 hours after dosing or until stopped by the participant, or rescue medication was administered. (NCT01216163)
Timeframe: 0 to 6 hours
| Intervention | minutes (Median) |
|---|---|
| Placebo | NA |
| Ibuprofen Sodium | 58.0 |
| Acetaminophen | 53.4 |
Median time of dropping out of the participants from the study due to lack of efficacy or use of rescue medication, whichever comes first. (NCT01216163)
Timeframe: 0 to 6 hours
| Intervention | hours (Median) |
|---|---|
| Placebo | 1.6 |
| Ibuprofen Sodium | NA |
| Acetaminophen | NA |
SPRID: time-weighted sum of pain relief rating combined with pain intensity difference (PRID) over 6 hours. Score range: -6(worst) to 42(best) for SPRID 0-6. PRID: sum of pain intensity difference (PID) and pain relief rating (PRR) at each time point. Score range for PRID: -1(worst) to 7(best). PID: baseline pain severity score minus pain severity score at a given time point (score range 0=none to 3=severe; baseline score range 2=moderate to 3=severe). Total score range for PID: -1 (worst) to 3 (best). PRR: assessed on 5-point pain relief rating scale (0=No relief to 4=Complete relief). (NCT01216163)
Timeframe: 0 to 6 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 2.8 |
| Ibuprofen Sodium | 20.0 |
| Acetaminophen | 17.1 |
Complete relief was defined as a PRR of 4. PRR was assessed on a 5-point categorical pain relief rating scale where 0=No relief to 4=Complete relief. (NCT01216163)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6 hours
| Intervention | percentage of participants (Number) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hours | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | |
| Acetaminophen | 1.2 | 4.7 | 15.3 | 24.7 | 29.4 | 32.9 | 35.3 | 35.3 | 35.3 |
| Ibuprofen Sodium | 0.0 | 6.8 | 23.9 | 29.5 | 36.4 | 42.0 | 45.5 | 45.5 | 46.6 |
| Placebo | 0.0 | 0.0 | 0.0 | 0.0 | 4.4 | 4.4 | 6.7 | 8.9 | 8.9 |
Percentage of participants with first perceptible relief evaluated by stopping the stopwatch labeled 'first perceptible relief' at the moment participant first began to experience any relief. First perceptible relief was considered confirmed if the participant also stopped the second stopwatch indicating meaningful relief. Stopwatch was active up to 6 hours after dosing or until stopped by the participant, or rescue medication was administered. (NCT01216163)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6 hours
| Intervention | percentage of participants (Number) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | |
| Acetaminophen | 24.7 | 62.4 | 72.9 | 74.1 | 74.1 | 74.1 | 74.1 | 74.1 | 74.1 |
| Ibuprofen Sodium | 28.4 | 64.8 | 78.4 | 79.5 | 79.5 | 79.5 | 79.5 | 79.5 | 79.5 |
| Placebo | 2.2 | 4.4 | 11.1 | 11.1 | 13.3 | 13.3 | 13.3 | 13.3 | 13.3 |
Percentage of participants with meaningful relief evaluated by stopping the stopwatch labeled 'meaningful relief' at the moment participant first began to experience meaningful relief. Stopwatch was active up to 6 hours after dosing or until stopped by the participant, or rescue medication was administered. (NCT01216163)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6 hours
| Intervention | percentage of participants (Number) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | |
| Acetaminophen | 0.0 | 20.0 | 56.5 | 64.7 | 70.6 | 71.8 | 74.1 | 74.1 | 74.1 |
| Ibuprofen Sodium | 0.0 | 21.6 | 53.4 | 72.7 | 75.0 | 77.3 | 78.4 | 79.5 | 79.5 |
| Placebo | 0.0 | 0.0 | 0.0 | 2.2 | 8.9 | 11.1 | 13.3 | 13.3 | 13.3 |
Percentage of participants who withdrew from the study due to lack of efficacy or received rescue medication. (NCT01216163)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6 hours
| Intervention | percentage of participants (Number) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | |
| Acetaminophen | 0.0 | 0.0 | 0.0 | 2.4 | 12.9 | 21.2 | 27.1 | 32.9 | 35.3 |
| Ibuprofen Sodium | 0.0 | 0.0 | 0.0 | 2.3 | 5.7 | 11.4 | 15.9 | 25.0 | 29.5 |
| Placebo | 0.0 | 0.0 | 0.0 | 42.2 | 68.9 | 82.2 | 82.2 | 82.2 | 82.2 |
PID was derived by subtracting the pain severity score at a given post-dosing time point (pain severity score range 0 [none] to 3 [severe]) from the baseline score (Baseline pain severity score range 2 [moderate] to 3 [severe]). Total possible score range for PID: -1 (worst) to 3 (best). (NCT01216163)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6 hours
| Intervention | units on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | |
| Acetaminophen | 0.2 | 0.5 | 1.0 | 1.1 | 1.1 | 0.9 | 0.9 | 0.8 | 0.6 |
| Ibuprofen Sodium | 0.3 | 0.8 | 1.3 | 1.3 | 1.3 | 1.2 | 1.1 | 0.9 | 0.9 |
| Placebo | -0.1 | -0.1 | 0.0 | -0.0 | -0.0 | -0.0 | -0.0 | 0.0 | -0.0 |
PRR was evaluated at different time points during the study up to 6 hours after taking the study medication, and immediately before rescue medication was taken (if necessary). PRR was assessed on a 5-point categorical pain relief rating scale where 0=No relief to 4=Complete relief. (NCT01216163)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6 hours
| Intervention | units on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | |
| Acetaminophen | 0.4 | 1.5 | 2.4 | 2.5 | 2.5 | 2.2 | 2.1 | 1.9 | 1.7 |
| Ibuprofen Sodium | 0.7 | 1.8 | 2.6 | 2.8 | 2.8 | 2.5 | 2.4 | 2.0 | 2.0 |
| Placebo | 0.1 | 0.3 | 0.6 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
PRID was sum of PID and PRR at each post-dosing time point. The overall possible score range, for PRID was -1 (worst) to 7 (best). PID was derived by subtracting the pain severity score at a given post-dosing time point (pain severity score range 0 [none] to 3 [severe]) from the baseline score (Baseline pain severity score range 2 [moderate] to 3 [severe]). Total possible score range for PID: -1 (worst) to 3 (best). PRR was assessed on 5-point categorical pain relief rating scale (0=No relief to 4=Complete relief). (NCT01216163)
Timeframe: 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6 hours
| Intervention | units on a scale (Mean) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 1.5 hours | 2 hours | 3 hours | 4 hours | 5 hours | 6 hours | |
| Acetaminophen | 0.6 | 2.0 | 3.4 | 3.7 | 3.6 | 3.1 | 3.0 | 2.7 | 2.3 |
| Ibuprofen Sodium | 0.9 | 2.5 | 3.9 | 4.1 | 4.1 | 3.7 | 3.6 | 2.9 | 2.8 |
| Placebo | 0.1 | 0.2 | 0.6 | 0.5 | 0.5 | 0.4 | 0.5 | 0.5 | 0.5 |
SPID: time-weighted sum of PID over 2, 3 and 6 hours. Total score range: -2 (worst) to 6 (best) for SPID 0-2, -3 (worst) to 9 (best) for SPID 0-3, and -6 (worst) to 18 (best) for SPID 0-6. PID: baseline pain severity score minus pain severity score at a given time point (score range 0=none to 3=severe; baseline score range 2=moderate to 3=severe). Total score range for PID: -1 (worst) to 3 (best). (NCT01216163)
Timeframe: 0 to 2, 0 to 3, 0 to 6 hours
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| SPID 0-2 | SPID 0-3 | SPID 0-6 | |
| Acetaminophen | 1.8 | 2.8 | 5.1 |
| Ibuprofen Sodium | 2.2 | 3.4 | 6.3 |
| Placebo | -0.1 | -0.1 | -0.1 |
TOTPAR: time-weighted sum of PRR over 2, 3, and 6 hours. Total score range: 0 (worst) to 8 (best) for TOTPAR 0-2, 0 (worst) to 12 (best) for TOTPAR 0-3, and 0 (worst) to 24 (best) for TOTPAR 0-6. PRR was evaluated at different time points during the study up to 6 hours, and immediately after taking rescue medication (if necessary). PRR was assessed on a 5-point categorical pain relief rating scale where 0=No relief to 4=Complete relief. (NCT01216163)
Timeframe: 0 to 2, 0 to 3, 0 to 6 hours
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| TOTPAR 0-2 | TOTPAR 0-3 | TOTPAR 0-6 | |
| Acetaminophen | 4.2 | 6.4 | 12.0 |
| Ibuprofen Sodium | 4.7 | 7.2 | 13.6 |
| Placebo | 0.9 | 1.4 | 2.9 |
SPRID: time-weighted sum of PRID over 2 and 3 hours. Total score range: -2 (worst) to 14 (best) for SPRID 0-2, and -3 (worst) to 21 (best) for SPRID 0-3. PRID: sum of PID and PRR at each time point. Total score range for PRID: -1=worst to 7=best. PID: baseline pain severity score minus pain severity score at a given time point (score range 0=none to 3=severe; baseline score range 2=moderate to 3=severe). Total score range for PID: -1 (worst) to 3 (best). PRR: assessed on 5-point pain relief rating scale (0=No relief to 4=Complete relief). (NCT01216163)
Timeframe: 0 to 2, 0 to 3 hours
| Intervention | units on a scale (Mean) | |
|---|---|---|
| SPRID 0-2 | SPRID 0-3 | |
| Acetaminophen | 6.0 | 9.1 |
| Ibuprofen Sodium | 6.9 | 10.6 |
| Placebo | 0.9 | 1.3 |
Percentage of participants who withdrew from the study due to lack of efficacy or received rescue medication. (NCT01362491)
Timeframe: 1, 2, 3 hours post-dose
| Intervention | percentage of participants (Number) |
|---|---|
| Ibuprofen Sodium | 0 |
| Ibuprofen (Motrin IB) | 0 |
| Placebo | 0 |
"Participants evaluated the time to first perceptible relief by stopping a stopwatch labeled 'first perceptible relief' at the moment the participant first began to experience any relief. Stopwatch was active up to 3 hours after dosing or until stopped by the participant, or rescue medication was administered. First perceptible relief was considered confirmed by meaningful relief if the participant achieved both first perceptible and meaningful relief by either depressing the second stopwatch or by indicating that his/her first perceptible relief was also meaningful." (NCT01362491)
Timeframe: 0 to 3 hours
| Intervention | minutes (Median) |
|---|---|
| Ibuprofen Sodium | 36.9 |
| Ibuprofen (Motrin IB) | 43.6 |
| Placebo | NA |
"Participants evaluated the time to meaningful relief by stopping a second stopwatch labeled 'meaningful relief' at the moment the participant first began to experience meaningful relief. It was also considered achieved if the participant stated meaningful relief at the time the first stopwatch was depressed. Stopwatch was active up to 3 hours after dosing or until stopped by the participant, or rescue medication was administered." (NCT01362491)
Timeframe: 0 to 3 hours
| Intervention | minutes (Median) |
|---|---|
| Ibuprofen Sodium | 40.6 |
| Ibuprofen (Motrin IB) | 48.5 |
"Participants evaluated the time to meaningful relief by stopping a second stopwatch labeled 'meaningful relief' at the moment the participant first began to experience meaningful relief. It was also considered achieved if the participant stated meaningful relief at the time the first stopwatch was depressed. Stopwatch was active up to 3 hours after dosing or until stopped by the participant, or rescue medication was administered." (NCT01362491)
Timeframe: 0 to 3 hours
| Intervention | minutes (Median) |
|---|---|
| Ibuprofen Sodium | 40.6 |
| Ibuprofen (Motrin IB) | 48.5 |
| Placebo | NA |
SPRID:time-weighted sum of pain relief rating combined with pain intensity difference (PRID) over 3 hours. SPRID score range:-3 (worst) to 21 (best) for SPRID 0-3. PRID: sum of pain intensity differences (PID) and pain relief rating(PRR) at each time point. PRID score range: -1=worst to 7=best. PID: baseline pain severity score minus pain severity score at a given time point (score range 0=none to 3=severe; baseline score range 2=moderately severe to 3=severe). Total score range for PID: -1(worst) to 3 (best). PRR:assessed on 5-point pain relief rating scale (0=No relief to 4=Complete relief). (NCT01362491)
Timeframe: 0-3 Hours
| Intervention | units on scale (Mean) |
|---|---|
| Ibuprofen Sodium | 9.6 |
| Placebo | 3.5 |
Complete relief was defined as a PRR of 4. PRR was assessed on a 5-point categorical pain relief rating scale where 0=No relief to 4=Complete relief (NCT01362491)
Timeframe: 1, 2, & 3 hours post-dose
| Intervention | percentage of participants (Number) | ||
|---|---|---|---|
| 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 0 | 4.5 | 38.2 |
| Ibuprofen Sodium | 0 | 5.5 | 37.4 |
| Placebo | 0 | 2.2 | 8.7 |
"Percentage of participants with first perceptible relief evaluated by stopping a stopwatch labeled 'first perceptible relief' at the moment the participant first began to experience any relief. Stopwatch was active up to 3 hours after dosing or until stopped by the participant, or rescue medication was administered. First perceptible relief was considered confirmed by meaningful relief if the participant achieved both first perceptible and meaningful relief by either depressing the second stopwatch or by indicating that his/her first perceptible relief was also meaningful." (NCT01362491)
Timeframe: 0.5, 1, 2, 3 hours
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| 0.5 hours | 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 7.9 | 74.2 | 86.5 | 86.5 |
| Ibuprofen Sodium | 18.7 | 76.9 | 85.7 | 85.7 |
| Placebo | 0 | 15.2 | 45.7 | 45.7 |
"Percentage of participants with meaningful relief evaluated by stopping a second stopwatch labeled 'meaningful relief' at the moment the participant first began to experience meaningful relief. It was also considered achieved if the participant stated meaningful relief at the time the first stopwatch was depressed. Stopwatch was active up to 3 hours after dosing or until stopped by the participant, or rescue medication was administered." (NCT01362491)
Timeframe: 0.5, 1, 2, 3 hours
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| 0.5 hours | 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 4.5 | 65.2 | 86.5 | 86.5 |
| Ibuprofen Sodium | 12.1 | 71.4 | 85.7 | 85.7 |
| Placebo | 0 | 13 | 39.1 | 45.7 |
PID was derived by subtracting the pain severity score at a given post-dosing time point [pain severity score range 0 (none) to 3 (severe)] from the baseline score [Baseline pain severity score range 2 (moderately severe) to 3 (severe)]. Total possible score range for PID: -1 (worst) to 3 (best). (NCT01362491)
Timeframe: 1, 2 & 3 hours post-dose
| Intervention | units on scale (Mean) | ||
|---|---|---|---|
| 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 0.7 | 1.0 | 1.4 |
| Ibuprofen Sodium | 0.7 | 1.0 | 1.3 |
| Placebo | 0.2 | 0.4 | 0.5 |
PRR was assessed on a 5-point categorical pain relief rating scale wherein 0=No relief to 4=Complete relief. (NCT01362491)
Timeframe: 1, 2 & 3 hours post-dose
| Intervention | units on scale (Mean) | ||
|---|---|---|---|
| 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 1.6 | 2.2 | 2.9 |
| Ibuprofen Sodium | 1.5 | 2.3 | 2.8 |
| Placebo | 0.3 | 1.0 | 1.2 |
PRID was sum of PID and PRR at each post-dosing time point. The overall possible score range, for PRID was -1 (worst) to 7 (best). PID was derived by subtracting the pain severity score at a given post-dosing time point [pain severity score range 0 (none) to 3 (severe)] from the baseline score [Baseline pain severity score range 2 (moderately severe) to 3 (severe)]. Total possible score range for PID: -1 (worst) to 3 (best). PRR was assessed on 5-point categorical pain relief rating scale (0=No relief to 4=Complete relief). (NCT01362491)
Timeframe: 1, 2 & 3 hours post-dose
| Intervention | units on scale (Mean) | ||
|---|---|---|---|
| 1 hour | 2 hours | 3 hours | |
| Ibuprofen (Motrin IB) | 2.2 | 3.2 | 4.3 |
| Ibuprofen Sodium | 2.3 | 3.2 | 4.1 |
| Placebo | 0.5 | 1.4 | 1.7 |
SPID: time-weighted sum of PID over 2 and 3 hours. SPID score range was -2(worst) to 6 (best) for SPID 0-2 and -3 (worst) to 9 (best) for SPID 0-3. PID: baseline pain severity score minus pain severity score at a given time point (score range 0=none to 3=severe; baseline score range 2=moderately severe to 3=severe). Total score range for PID: -1(worst) to 3 (best). (NCT01362491)
Timeframe: 0 to 2, 0 to 3 hours
| Intervention | units on scale (Mean) | |
|---|---|---|
| SPID 0-2 | SPID 0-3 | |
| Ibuprofen (Motrin IB) | 1.7 | 3.1 |
| Ibuprofen Sodium | 1.7 | 3.0 |
| Placebo | 0.5 | 1.0 |
TOTPAR: time-weighted sum of PRR over 2 and 3 hours. TOTPAR score range was 0 (worst) to 8 (best) for TOTPAR 0-2 and 0 (worst) to 12 (best) for TOTPAR 0-3. PRR was assessed on a 5-point categorical pain relief rating scale wherein 0=No relief to 4=Complete relief. (NCT01362491)
Timeframe: 0 to 2, 0 to 3 hours
| Intervention | units on scale (Mean) | |
|---|---|---|
| TOTPAR 0-2 | TOTPAR 0-3 | |
| Ibuprofen (Motrin IB) | 3.8 | 6.6 |
| Ibuprofen Sodium | 3.8 | 6.6 |
| Placebo | 1.3 | 2.5 |
SPRID: time-weighted sum of PRID over 2 and 3 hours. SPRID score range was -2(worst) to 14(best) for SPRID 0-2 and -3 (worst) to 21 (best) for SPRID 0-3. PRID: sum of PID and PRR at each time point. Total score range for PRID: -1=worst to 7=best. PID: baseline pain severity score minus pain severity score at a given time point (score range 0=none to 3=severe; baseline score range 2=moderately severe to 3=severe). Total score range for PID: -1(worst) to 3(best), PRR: assessed on 5-point pain relief rating scale (0=No relief to 4=Complete relief). (NCT01362491)
Timeframe: 0 to 2, 0 to 3 hours
| Intervention | units on scale (Mean) | |
|---|---|---|
| SPRID 0-2 | SPRID 0-3 | |
| Ibuprofen (Motrin IB) | 5.5 | 9.8 |
| Ibuprofen Sodium | 5.5 | 9.6 |
| Placebo | 1.8 | 3.5 |
Global assessment of study medication was performed at the 8-hours time point or immediately before taking rescue medication (if necessary). It was scored on a 5-point categorical scale where 0=poor, 1=fair, 2=good, 3=very good, and 4=excellent. (NCT01035346)
Timeframe: 8 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 1.8 |
| Ibuprofen Sodium | 2.5 |
Rating of study medication was performed at the 8-hours time point or immediately before taking rescue medication (if necessary). It was scored on a 5-point categorical scale where 0=poor, 1=fair, 2=good, 3=very good, and 4=excellent. (NCT01035346)
Timeframe: 8 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 1.5 |
| Ibuprofen Sodium | 2.4 |
Median time of dropping out of the participants from the study due to lack of efficacy or use of rescue medication, whichever comes first. (NCT01035346)
Timeframe: 0 to 8 hours
| Intervention | hours (Median) |
|---|---|
| Placebo | NA |
| Ibuprofen Sodium | NA |
STEMPD 0-6 was defined as time-weighted sum of temperature differences over 6 hours, weighted by the time elapsed between each 2 consecutive time points. Temperature difference was defined as baseline temperature minus post-baseline temperature at each time point, where positive value indicated improvement in body temperature. (NCT01035346)
Timeframe: 0 to 6 hours
| Intervention | Degrees Fahrenheit (Mean) |
|---|---|
| Placebo | 3.0 |
| Ibuprofen Sodium | 10.8 |
Change from baseline in temperature was calculated as baseline temperature minus post-baseline temperature at each time point, where positive value indicated improvement in body temperature. (NCT01035346)
Timeframe: Baseline, 0.25, 0.5, 1, 2, 4, 6, 8 hours
| Intervention | Degrees Fahrenheit (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 2 hours | 4 hours | 6 hours | 8 hours | |
| Ibuprofen Sodium | 0.4 | 0.7 | 1.2 | 1.9 | 2.0 | 2.1 | 1.3 |
| Placebo | 0.4 | 0.5 | 0.3 | 0.8 | 0.3 | 0.7 | 1.3 |
Percentage of participants who withdrew from the study due to lack of efficacy or received rescue medication. (NCT01035346)
Timeframe: 0.25, 0.5, 1, 2, 4, 6, 8 hours
| Intervention | percentage of participants (Number) | ||||||
|---|---|---|---|---|---|---|---|
| 0.25 hours | 0.5 hours | 1 hour | 2 hours | 4 hours | 6 hours | 8 hours | |
| Ibuprofen Sodium | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 11.1 |
| Placebo | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
STEMPD 0-4 and STEMPD 0-8 were defined as the time-weighted sum of temperature differences over 4 hours and 8 hours, weighted by the time elapsed between each 2 consecutive time points. Temperature difference was defined as baseline temperature minus post-baseline temperature at each time point, where positive value indicated improvement in body temperature. (NCT01035346)
Timeframe: 0 to 4, 0 to 8 hours
| Intervention | Degrees Fahrenheit (Mean) | |
|---|---|---|
| STEMPD 0-4 | STEMPD 0-8 | |
| Ibuprofen Sodium | 6.7 | 13.4 |
| Placebo | 1.7 | 5.7 |
proportion of study days on which asthma was controlled, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | proportion of days (Mean) |
|---|---|
| Acetaminophen | .86 |
| Ibuprofen | .87 |
average albuterol rescue use per week, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | inhalations per week (Mean) |
|---|---|
| Acetaminophen | 2.8 |
| Ibuprofen | 3 |
the number of asthma exacerbations requiring systemic corticosteroids (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | asthma exacerbations per 46 weeks (Mean) |
|---|---|
| Acetaminophen | 0.81 |
| Ibuprofen | .87 |
frequency of unscheduled physician visits, emergency department visits or hospitalizations for asthma (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | unscheduled health visits per 46 weeks (Mean) |
|---|---|
| Acetaminophen | .75 |
| Ibuprofen | .76 |
The patient marked their pain on a 0 to 10cm visual analogue scale, where 0 cm is no pain and 10 cm is the worst pain ever. (NCT01664559)
Timeframe: Pain with IUD placement, measured immediately after placement
| Intervention | units on a scale (Median) |
|---|---|
| Placebo With 1cc Normal Saline IM | 5.2 |
| Toradol, 30mg in 1cc IM | 3.6 |
"The patient marked their pain on a 0 to 10cm visual analogue scale, where 0 cm is no pain and 10 cm is the worst pain ever.~Prior to injection of study drug, anticipated pain~Pain from study drug injection, measured immediately after injection~Pain from speculum insertion, measured immediately after insertion~Pain with tenaculum placement, measured immediately after placement~Pain with uterine sounding, measured immediately after removal of the sound~Pain at 5 minutes after placement of the intrauterine device~Pain at 15 minutes after placement of the intrauterine device" (NCT01664559)
Timeframe: immediately after each step (see description)
| Intervention | cm (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| 1) Anticipated pain | 2) Pain with injection | 3) Speculum insertion | 4) Tenaculum placement | 5) Uterine sounding | 6) Pain with IUD placement | 7) 5 min after placement | 8) 15 min after placement | |
| Placebo With 1cc Normal Saline IM | 2.8 | 1.8 | 2.3 | 6.3 | 8.4 | 8.1 | 3.7 | 4.8 |
| Toradol, 30mg in 1cc IM | 3.6 | 1.2 | 1.5 | 4.3 | 6.0 | 5.4 | 2.7 | 1.8 |
"The patient marked their pain on a 0 to 10cm visual analogue scale, where 0 cm is no pain and 10 cm is the worst pain ever.~Prior to injection of study drug, anticipated pain~Pain from study drug injection, measured immediately after injection~Pain from speculum insertion, measured immediately after insertion~Pain with tenaculum placement, measured immediately after placement~Pain with uterine sounding, measured immediately after removal of the sound~Pain at 5 minutes after placement of the intrauterine device~Pain at 15 minutes after placement of the intrauterine device" (NCT01664559)
Timeframe: immediately after each step (see description)
| Intervention | cm (Median) | ||||||
|---|---|---|---|---|---|---|---|
| Anticipated pain | Pain with injection | Speculum insertion | Tenaculum placement | Uterine sounding | 5 min after procedure | 15 min after procedure | |
| Placebo With 1cc Normal Saline IM | 4.4 | 1.0 | 2.6 | 3.9 | 5.0 | 2.2 | 1.6 |
| Toradol, 30mg in 1cc IM | 3.5 | 0.6 | 1.5 | 2.5 | 4.3 | 0.3 | 0.1 |
"Questions assessed in multiple choice format:~Side effects~injection site pain~overall satisfaction with IUD insertion experience~would they still recommend IUD placement to a friend?~significant pain for which they desired acetaminophen prior to leaving the office?" (NCT01664559)
Timeframe: assessed at 15 minutes after IUD insertion
| Intervention | participants (Number) | ||||
|---|---|---|---|---|---|
| Reported side effects | Injection site pain - just as bad/worse than IUD | Satisfied or very satisfied with overall IUD proc | Recommend IUD to a friend | Desires additional pain medication | |
| Placebo With 1cc Normal Saline IM | 12 | 8 | 30 | 28 | 16 |
| Toradol, 30mg in 1cc IM | 8 | 6 | 31 | 30 | 6 |
"The provider will be asked to fill out a multiple choice format questionnaire:~what level training are you?~which IUD was inserted?~what was the purpose of IUD placement?~what was the position of the uterus?~did the IUD placement process require cervical dilation?~were you able to complete the IUD insertion?~was there bleeding from the cervix that required more than 5 min to control?~were there any major complications with the IUD insertion?~did the patient take tylenol prior to leaving the office?" (NCT01664559)
Timeframe: Immediately after IUD placement, on average within 1 hour
| Intervention | participants (Number) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Level of training - PGY1 | Level of training - PGY2 | Level of training - PGY3 | Level of training - PGY4 | Level of training - Attending | IUD type - levonogestrel | IUD type - copper | Purpose of IUD - contraception | Purpose of IUD - AUB | Position of uterus - anteverted | Position of uterus - retroverted | Position of uterus - midpositioned | Cervical dilation needed | Able to complete the IUD placement | Significant bleeding | Major complications | Took acetaminophen prior to leaving the office | |
| Placebo With 1cc Normal Saline IM | 2 | 2 | 3 | 5 | 1 | 22 | 12 | 33 | 1 | 19 | 6 | 9 | 2 | 34 | 0 | 0 | 17 |
| Toradol, 30mg in 1cc IM | 5 | 13 | 6 | 6 | 3 | 28 | 2 | 32 | 1 | 20 | 5 | 8 | 2 | 33 | 2 | 0 | 7 |
A semi-structured interview guide(available in both English and Spanish) which was developed in consultation with an expert in qualitative methodology at the UNM Clinical & Translational Science Center (CTSC), and UNMH family planning experts, will be administered to all participants. The interview will incorporate the following domains of women's perceptions of the postplacental IUD insertion experience: decisional influence, experience during the procedure, decisional regret, prior knowledge/ awareness of the method and postpartum contraception in general. The interview will conclude with an overall patient satisfaction score measured on a five-point Likert scale: 1 = very dissatisfied, 2 = somewhat dissatisfied, 3 = neutral, 4 = somewhat satisfied, 5 = very satisfied. (NCT02312726)
Timeframe: Within 24-48 hours after vaginal delivery, prior to hospital discharge
| Intervention | participants (Number) | ||||
|---|---|---|---|---|---|
| Very Satified | Satisfied | Neutral | Dissatisfied | Very Dissatisfied | |
| Epidural Group | 12 | 0 | 0 | 0 | 0 |
| Non Epidural Group | 7 | 2 | 0 | 0 | 0 |
This is a 4-item ordinal pain scale which has been used for pain level assessment. When prompted, patients will be asked to indicate which level of pain most accurately represents their pain level; 0 = No pain, 1 = Mild pain, 2 = Moderate pain, 3 = Severe pain. (NCT02312726)
Timeframe: Immediately prior to and within 5 minutes after IUD insertion following vaginal delivery. Women who undergo a postpartum interview will be asked to perform a recal VRS pain assessment
| Intervention | participants (Number) | |||||
|---|---|---|---|---|---|---|
| No Pain or Mild Pain before IUD placement | No Pain or Mild Pain during IUD placement | No Pain or Mild Pain at recall | Moderate Pain or Severe Pain before IUD placement | Moderate Pain or Severe Pain during IUD placement | Moderate Pain or Severe Pain at recall | |
| Epidural Group | 34 | 32 | 12 | 2 | 4 | 0 |
| Non Epidural Group | 15 | 16 | 6 | 15 | 14 | 3 |
This is a validated instrument used extensively in the assessment of acute pain. When prompted, patients will be asked to mark the continuous 100 mm VAS line at the point which most accurately represents their pain level; 0 = no pain, 100 = pain as bad as it could be. (NCT02312726)
Timeframe: Immediately prior to and within 5 minutes after IUD insertion following vaginal delivery; women who undergo a postpartum interview will be asked to perform a recall VAS pain assessment
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Pre-insertion | Procedure | Recall | |
| Epidural Group | 10.6 | 10.9 | 5.4 |
| Non Epidural Group | 35.3 | 41.4 | 28.6 |
The provider who inserts the IUD will be asked to complete a 4-item Likert scale rating perceived difficultly of insertion: 1 = easy; 2 = somewhat easy; 3 = somewhat difficult, 4 = difficult. (NCT02312726)
Timeframe: Within 5 minutes following postpartum IUD insertion
| Intervention | participants (Number) | ||||
|---|---|---|---|---|---|
| Easy | Somewhat easy | Somewhat difficult | Difficult | Unanswered | |
| Epidural Group | 19 | 16 | 3 | 0 | 0 |
| Non Epidural Group | 15 | 11 | 3 | 0 | 1 |
Distance (mm) from the left of the 100-mm visual analog scale (reflecting magnitude of pain) recorded at time of IUD Placement. Scale range is from 0mm (no pain) to 100mm (worst pain possible). A lower score (less pain) is considered a better outcome. (NCT02219308)
Timeframe: Moment of IUD insertion
| Intervention | mm (Median) |
|---|---|
| No Paracervical Block (Sham PCB) | 54 |
| Paracervical Block (PCB) | 33 |
Distance (mm) from the left of the 100-mm visual analog scale of pain at various time points. Scale range is 0mm (no pain) to 100mm (worst pain possible). Lower scores are considered better outcomes. (NCT02219308)
Timeframe: Anticipation of procedure through 5 minutes after IUD placement
| Intervention | mm (Median) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Anticipated Pain | Baseline Pain | Speculum Insertion | Capped Needle or PCB | Tenaculum placement | Uterine Sounding | IUD placement | 5 mins after IUD placement | Overall pain | |
| No Paracervical Block (Sham PCB) | 51 | 0 | 6 | 8 | 10 | 47 | 54 | 27 | 51 |
| Paracervical Block (PCB) | 58 | 0 | 10 | 30 | 15 | 30 | 33 | 12 | 30 |
Baseline pain scores prior to IUD insertion is assessed using a 0-100mm VAS with anchors 0 equals no pain and 100 equals worst pain imaginable. The minimal clinically important difference in pain for this study was set at 15mm. (NCT02391714)
Timeframe: Before the IUD insertion procedure
| Intervention | units on a scale (Mean) |
|---|---|
| Oxygen (Placebo) | 1.9 |
| Nitrous Oxide (NO) | 2.4 |
Pain is assessed using a 0-100mm VAS with anchors 0 equals no pain and 100 equals worst pain imaginable. The minimal clinically important difference in pain for this study was set at 15mm. (NCT02391714)
Timeframe: 2 minutes after the procedure.
| Intervention | units on a scale (Mean) |
|---|---|
| Oxygen (Placebo) | 55.3 |
| Nitrous Oxide (NO) | 54.3 |
Satisfaction will be measured using a 100mm Visual Analog Scale (VAS), with anchors 0mm for very satisfied and 100mm for very dissatisfied. (NCT02391714)
Timeframe: Prior to clinic discharge, which is an average of 15 minutes after the procedure
| Intervention | units on a scale (Mean) |
|---|---|
| Oxygen (Placebo) | 60.3 |
| Nitrous Oxide (NO) | 66.0 |
"Using a visual analog scale, women will report their level of pain pre-procedure, after tenaculum placement, and post-procedure (following IUD insertion).The entirety of the procedure should last no more than 5-10 minutes. The pain score is assessed at the 3 timepoints within that 10 minute window. No additional followup is required.~Range: 0-10 (0= no pain, 10=worst pain)" (NCT01411995)
Timeframe: Immediately following IUD insertion
| Intervention | units on visual analog scale (Median) |
|---|---|
| 2% Lidocaine Gel | 5 |
| Water Based Lubricant | 6 |
Average number of post-operative days with pain score >4/10. Pain score assessments were administered once daily by parents using either the Numeric Rating Scale (NRS-11) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 8-15 (von Baeyer et al., 2009) or the Faces Pain Scale-Revised (FPS-R) (with anchors 0=no pain and 10=highest pain imaginable) for children ages 4-10 (Hicks et al., 2001). (NCT01267136)
Timeframe: Efficacy was assessed daily during the 10-day postoperative recovery period.
| Intervention | days (Median) |
|---|---|
| Capital® With Codeine Suspension | 1.5 |
| Tramadol Suspension | 1 |
Parent-reported side effects entered in 10-day diary. (NCT01267136)
Timeframe: Side effects will be observed and recorded daily by caregivers for a total of 10 days in the take-home diary.
| Intervention | participants (Number) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Nausea | Vomiting | Fever | Itching | Rash | Sweating | Dizziness | Headache | Constipation | Oversedation | Tonsil bleed | |
| Capital® With Codeine Suspension | 20 | 21 | 11 | 5 | 1 | 9 | 15 | 12 | 21 | 14 | 3 |
| Tramadol Suspension | 20 | 18 | 10 | 12 | 1 | 7 | 17 | 17 | 21 | 8 | 0 |
Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)
| Intervention | Participants (Count of Participants) |
|---|---|
| Baseline | 0 |
| 48-72 Hours After Vaccination | 0 |
| 21-28 Days After Vaccination | 0 |
Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)
| Intervention | Participants (Count of Participants) |
|---|---|
| Baseline | 0 |
| 48-72 Hours After Vaccination | 0 |
| 21-28 Days After Vaccination | 0 |
A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.
| Intervention | mmol/L (Mean) | |
|---|---|---|
| Lactate before pushups | Lactate after pushups | |
| Compound Exercise of Push-ups | 1.51 | 7.69 |
Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Visit 1 | Visit 2 | Visit 3 | |
| Compound Exercise of Push-ups | .14 | .19 | .13 |
| Ibuprofen | .39 | .56 | .28 |
| Placebo | .19 | .22 | .06 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 214.80 | 345.09 |
| Ibuprofen | 171.00 | 239.25 |
| Placebo | 216.75 | 343.03 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 149.22 | 232.58 |
| Ibuprofen | 177.78 | 243.13 |
| Placebo | 221.09 | 296.66 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 26.00 | 41.02 |
| Ibuprofen | 17.41 | 25.47 |
| Placebo | 26.09 | 34.09 |
Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)
| Intervention | Titer (Mean) | |
|---|---|---|
| Baseline (day 0, visit 1) | Followup (between 21-28 days, visit 3) | |
| Compound Exercise of Push-ups | 32.89 | 49.07 |
| Ibuprofen | 40.16 | 47.34 |
| Placebo | 36.69 | 44.78 |
"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) recorded at time immediately after osmotic dilator placement. 0 mm=No Pain and 100 mm= worst possible pain. A higher score indicates a higher level of pain." (NCT02354092)
Timeframe: Within 5 minutes of PCB or sham procedure
| Intervention | units on a scale (Mean) |
|---|---|
| Sham Group | 46 |
| Paracervical Block Group | 32 |
"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) recorded 15 minutes after osmotic dilator placement. mm=No Pain and 100 mm= worst possible pain. A higher mean score indicates a higher level of pain experienced at this time point." (NCT02354092)
Timeframe: 15 minutes after dilator placement
| Intervention | units on a scale (Mean) |
|---|---|
| Sham Group | 42 |
| Paracervical Block Group | 35 |
"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) recorded at time immediately after last injection for paracervical block OR script for sham injection. 0 mm=No Pain and 100 mm= worst possible pain. A higher score indicates a higher level of pain." (NCT02354092)
Timeframe: Within 5 minutes after baseline
| Intervention | units on a scale (Mean) |
|---|---|
| Sham Group | 19 |
| Paracervical Block Group | 39 |
"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) of pain recorded at baseline prior to the paracervical block or sham block procedure. 0 mm=No Pain and 100 mm= worst possible pain. A higher score indicates a higher level of pain." (NCT02354092)
Timeframe: Baseline, just prior to PCB or sham procedure
| Intervention | units on a scale (Mean) |
|---|---|
| Sham Group | 4 |
| Paracervical Block Group | 19 |
fever, chills, vomiting, heavy bleeding/clots (collected without regard to the specific event) (NCT00617097)
Timeframe: end of study (upon discharge from facility after procedure)
| Intervention | participants (Number) |
|---|---|
| Paracervical Block With Lidocaine | 3 |
| Paracervical Block With Ketorolac and Lidocaine | 0 |
100-mm Visual Analogue Scale -- minimum: 0 mm (lower satisfaction), maximum: 100 mm (greater satisfaction) (NCT00617097)
Timeframe: end of study (prior to clinic discharge)
| Intervention | mm (Mean) |
|---|---|
| Paracervical Block With Lidocaine | 62.9 |
| Paracervical Block With Ketorolac and Lidocaine | 63.6 |
(NCT00617097)
Timeframe: end of study
| Intervention | participants (Number) | |
|---|---|---|
| minor | serious | |
| Paracervical Block With Ketorolac and Lidocaine | 1 | 2 |
| Paracervical Block With Lidocaine | 1 | 0 |
"100-mm Visual Analogue Scale (VAS) during specific time intervals of D&C procedure: minimum: 0 mm (less pain); maximum: 100 mm (more pain)~Time intervals include: basline expected level of pain during procedure, after speculum insertion, at paracervical block injection, after dilation, end of procedure, and 30 minutes after procedure." (NCT00617097)
Timeframe: Baseline, Speculum Insertion, at Paracervical block injection, After dilation, End of procedure, 30 minutes after procedure
| Intervention | mm (Mean) | |||||
|---|---|---|---|---|---|---|
| expected level of pain during procedure | after speculum insertion | during paracervical block administration | after cervical dilation | immediately after procedure | 30 min after procedure | |
| Paracervical Block With Ketorolac and Lidocaine | 51.7 | 32.7 | 46.0 | 59.8 | 64.3 | 17.6 |
| Paracervical Block With Lidocaine | 52.2 | 33.6 | 50.8 | 74.8 | 61.5 | 21.8 |
Change in amygdala activation following administration of placebo, 200mg of ibuprofen or 600mg of ibuprofen (NCT02507219)
Timeframe: 3-6 weeks
| Intervention | percent signal change (Mean) | |
|---|---|---|
| Left amygdala | Right amygdala | |
| Ibuprofen, 200mg | 0.21 | 0.23 |
| Ibuprofen, 600mg | 0.23 | 0.17 |
| Placebo | 0.20 | 0.23 |
Pain is measured on a visual analog scale 0=no pain and 10=worst pain imaginable. (NCT02268955)
Timeframe: 120 minutes post medication administration
| Intervention | score on a scale (Median) |
|---|---|
| Control Group: Adults Age 18-55 Years | 3.0 |
| IV Ibuprofen: Adults Age 18-55 Years | 0.3 |
Change in pain at day 14 as measured by 11-point Box Pain Scale, 0 being the least amount of pain, and 10 the most amount of pain (NCT00264381)
Timeframe: Day 1, Day 14
| Intervention | units on a scale (Mean) |
|---|---|
| Ibuprofen 800 mg Tid | -2.28 |
| Dalteparin 200 U/kg Then 10,000 U Daily | -2.23 |
Number of participants with bleeding events related to treatment (NCT00264381)
Timeframe: 3 months
| Intervention | participants (Number) |
|---|---|
| Ibuprofen 800 mg Tid | 0 |
| Dalteparin 200 U/kg Then 10,000 U Daily | 0 |
Thrombosis progression and deep vein thrombosis at day 14 by ultrasound testing (NCT00264381)
Timeframe: Day 14
| Intervention | participants (Number) | |
|---|---|---|
| Thrombosis progression | VTE | |
| Dalteparin 200 U/kg Then 10,000 U Daily | 0 | 0 |
| Ibuprofen 800 mg Tid | 4 | 0 |
Symptomatic thrombosis extension (DVT) or pulmonary embolism at 3 months documented by radiologic testing. (NCT00264381)
Timeframe: 3 months
| Intervention | participants (Number) | |
|---|---|---|
| Thrombosis progression | VTE | |
| Dalteparin 200 U/kg Then 10,000 U Daily | 4 | 1 |
| Ibuprofen 800 mg Tid | 6 | 0 |
To assess need for additional intraoperative and/or postoperative pain medication (NCT01330459)
Timeframe: 30 minutes after completion of the procedure (which started 45-90 minutes after study drug administration)
| Intervention | Participants (Count of Participants) |
|---|---|
| Hydrocodone/Acetaminophen | 0 |
| Placebo | 0 |
To determine whether HC/APAP, given in addition to a standard regimen of ibuprofen, lorazepam, and PCB, affects patient pain perception at the time of uterine aspiration, as measured by distance (mm) from the left of the 100 mm visual analog scale (VAS). The number 0 indicates no pain, and 100 indicates worst pain imaginable. (NCT01330459)
Timeframe: At time of uterine aspiration (baseline)
| Intervention | mm (Mean) |
|---|---|
| Hydrocodone/Acetaminophen | 65.7 |
| Placebo | 63.1 |
Distance (mm) from the left of the 100 mm VAS scale (VAS anchors: 0 = none, 100 mm = worst imaginable) recorded after cervical dilation (NCT01330459)
Timeframe: During procedure (approximately 45-90 min after hydrocodone/acetaminophen or placebo, and within 5 minutes of procedure starting)
| Intervention | mm (Mean) |
|---|---|
| Hydrocodone/Acetaminophen | 47.2 |
| Placebo | 43.9 |
To assess whether HC/APAP is associated with nausea, measured on the 100 mm VAS, recorded 30 minutes postoperatively. VAS anchors: 0 indicates no pain, and 100 indicates worst pain imaginable. (NCT01330459)
Timeframe: 30 minutes after completion of the procedure (which started 45-90 minutes after study drug administration)
| Intervention | mm (Mean) |
|---|---|
| Hydrocodone/Acetaminophen | 19.4 |
| Placebo | 11.4 |
Distance (mm) from the left of the 100 mm VAS (VAS anchors: 0 = unsatisfied, 100 mm = very satisfied) recorded 30 minutes after completion of the procedure. (NCT01330459)
Timeframe: 30 minutes after completion of the procedure (which started 45-90 minutes after study drug administration)
| Intervention | mm (Mean) |
|---|---|
| Hydrocodone/Acetaminophen | 74.8 |
| Placebo | 67.3 |
For the primary outcome, pain immediately after paracervical block injection was measured by a scale. The scale used was the 100-mm visual analog scale. The minimum score was 0 and the maximum score was 100. Higher numbers indicate worse pain. (NCT03107754)
Timeframe: Immediately after injection of the paracervical block
| Intervention | units on a scale (Median) |
|---|---|
| Standard Paracervical Block | 44.5 |
| Buffered Lidocaine Paracervical Block | 30 |
Pain scores were measured at multiple points throughout the procedure. Pain scores were measured using a 100 mm visual analog scale with 0 being no pain and 100 being the worst pain ever. (NCT03107754)
Timeframe: Immediately after speculum placement, cervical dilation, uterine aspiration
| Intervention | units on a scale (Median) | ||
|---|---|---|---|
| After insertion of speculum | After cervical dilation | After uterine aspiration | |
| Buffered Lidocaine Paracervical Block | 17 | 55 | 69 |
| Standard Paracervical Block | 13 | 60.06 | 67.5 |
76 reviews available for ibuprofen and Ache
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Safety of Ibuprofen in Children With G6PD Deficiency: A Systematic Review.
Topics: Child; Glucosephosphate Dehydrogenase Deficiency; Hemolysis; Humans; Ibuprofen; Pain; Pharmaceutical | 2022 |
Systematic review and meta-analysis of studies in which burrowing behaviour was assessed in rodent models of disease-associated persistent pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Disease M | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Pain management for medical abortion before 14 weeks' gestation.
Topics: Abortion, Induced; Abortion, Spontaneous; Acetaminophen; Female; Humans; Ibuprofen; Mifepristone; Mi | 2022 |
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; C | 2022 |
Pain management for medical abortion before 14 weeks' gestation: A systematic review.
Topics: Female; Humans; Ibuprofen; Mifepristone; Misoprostol; Observational Studies as Topic; Pain; Pain Man | 2022 |
Sugar-free chewing gum versus conventional analgesic drugs for pain relief with fixed orthodontic appliances. A systematic review and meta-analysis.
Topics: Analgesics; Chewing Gum; Humans; Ibuprofen; Orthodontic Appliances, Fixed; Pain | 2023 |
Pharmacokinetic and pharmacodynamic herb-drug interactions of common over-the-counter pain medications.
Topics: Acetaminophen; Aspirin; Herb-Drug Interactions; Humans; Ibuprofen; Naproxen; Pain | 2023 |
Common Selfcare Indications of Pain Medications in Children.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; COVID-19; Fever; Humans; Ibuprofen; Pain | 2023 |
Ibuprofen in the Management of Viral Infections: The Lesson of COVID-19 for Its Use in a Clinical Setting.
Topics: Anti-Inflammatory Agents, Non-Steroidal; COVID-19; Humans; Ibuprofen; Inflammation; Pain | 2023 |
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews.
Topics: Acetaminophen; Analgesics, Opioid; Cerebral Hemorrhage; Female; Heroin; Humans; Ibuprofen; Infant, N | 2023 |
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans; | 2023 |
Ibuprofen Safety at the Golden Anniversary: Are all NSAIDs the Same? A Narrative Review.
Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dose-Response R | 2020 |
Narrative Summary of Recently Published Literature on Intravenous Ibuprofen.
Topics: Administration, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Pain; Pain | 2020 |
The efficacy of analgesics in controlling orthodontic pain: a systematic review and meta-analysis.
Topics: Acetaminophen; Analgesics; Humans; Ibuprofen; Pain; Pain Management | 2020 |
Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years: A Systematic Review and Meta-analysis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Female; Fever; Humans; Ibu | 2020 |
Ibuprofen vs. Acetaminophen for Fever or Pain in Children Younger Than Two Years.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Fever; Humans; Ibuprofen; Infant; Pain; Patient Selection; | 2021 |
Pain Management in Children: NSAID Use in the Perioperative and Emergency Department Settings.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug-Related Side Effects and Ad | 2021 |
Comparative efficacy and dysmenorrhea score of 6 object-separated moxibustions for the treatment of Chinese patients with dysmenorrhea: A systematic review and network meta-analysis.
Topics: Analgesics, Non-Narcotic; Bayes Theorem; China; Dysmenorrhea; Female; Humans; Ibuprofen; Moxibustion | 2021 |
Pharmacological Means of Pain Control during Separator Placement: A Systematic Review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Ibuprofen; Pain; Pain Management; Pain Measurement; | 2021 |
[Revision of the Dutch College of General Practitioners practice guideline 'Children with fever'].
Topics: Acetaminophen; Child; Family Practice; Fever; General Practitioners; Humans; Ibuprofen; Netherlands; | 2017 |
Efficacy and Safety of Ibuprofen in Infants Aged Between 3 and 6 Months.
Topics: Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Fever; Humans; Ibuprofen; Infant; Pain; Pain Man | 2017 |
Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal.
Topics: Abnormalities, Multiple; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cerebellar Di | 2017 |
Ibuprofen and Low-level Laser Therapy for Pain Control during Fixed Orthodontic Therapy: A Systematic Review of Randomized Controlled Trials and Meta-analysis.
Topics: Analgesics, Non-Narcotic; Humans; Ibuprofen; Low-Level Light Therapy; Orthodontic Appliances; Pain; | 2017 |
Efficacy of ibuprofen on prevention of high altitude headache: A systematic review and meta-analysis.
Topics: Altitude; Anti-Inflammatory Agents, Non-Steroidal; Databases, Factual; Headache; Humans; Ibuprofen; | 2017 |
Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Humans; Ibuprofen; Inflamm | 2019 |
Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Contraindications, Drug; Dengue; Fever; Hemorrhage; Humans; | 2019 |
Does long-term use of pain relievers have an impact on the rate of orthodontic tooth movement? A systematic review of animal studies.
Topics: Acetaminophen; Analgesics; Animals; Humans; Ibuprofen; Pain; Tooth Movement Techniques | 2019 |
Effectiveness of different debonding techniques and adjunctive methods on pain and discomfort perception during debonding fixed orthodontic appliances: a systematic review.
Topics: Acetaminophen; Adolescent; Adult; Child; Dental Care; Female; Humans; Ibuprofen; Middle Aged; Orthod | 2019 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Chemistry, Pharmaceutical; Child; Double-Blind Me | 2015 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Lidocaine; | 2015 |
Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Commerce; | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2016 |
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Age | 2016 |
Comparing the effectiveness profile of pharmacological interventions used for orthodontic pain relief: an arm-based multilevel network meta-analysis of longitudinal data.
Topics: Acetaminophen; Analgesics; Drug Administration Schedule; Etoricoxib; Humans; Ibuprofen; Network Meta | 2017 |
Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists.
Topics: Acetaminophen; Age Factors; Analgesics; Anesthesiology; Biological Availability; Cyclooxygenase Inhi | 2008 |
Topical dressings to manage pain in venous leg ulceration.
Topics: Administration, Topical; Analgesics, Opioid; Bandages; Bandages, Hydrocolloid; Humans; Ibuprofen; Ne | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Interventions for pain with intrauterine device insertion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Intrauterine Devices; Misoprosto | 2009 |
Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Anaphylaxis; Child; Fever; Gastrointestinal Hem | 2009 |
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C | 2009 |
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C | 2009 |
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C | 2009 |
Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analyses.
Topics: Acetaminophen; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Child; C | 2009 |
Clinical safety and tolerability of ibuprofen compared with paracetamol in pediatric pain and fever. A systematic review.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Fever; Humans; Ibuprofen; Pain | 2009 |
Ibuprofen: pharmacology, efficacy and safety.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Child; Dose-Response Relationship, Drug; Fe | 2009 |
Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review.
Topics: Acetaminophen; Adult; Age Factors; Analgesics, Non-Narcotic; Child; Female; Fever; Humans; Ibuprofen | 2010 |
[Physiotherapy in patients with chronic pain].
Topics: Analgesics, Non-Narcotic; Back Pain; Chronic Disease; Combined Modality Therapy; Exercise Movement T | 2010 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Anesthetics, Local; Bandages; Debridement; Humans | 2010 |
Pain management of musculoskeletal injuries in children: current state and future directions.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Codeine; Cytochrome P-450 CYP2D6 | 2010 |
Clinical inquiries. Which treatments provide the most relief for pharyngitis pain?
Topics: Acetaminophen; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Evidenc | 2011 |
Short-term acetylsalicylic acid (aspirin) use for pain, fever, or colds - gastrointestinal adverse effects: a meta-analysis of randomized clinical trials.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Common Cold; Double-Blind Me | 2011 |
Red ear syndrome: case report and review of the literature.
Topics: Adult; Analgesics, Non-Narcotic; Ear Diseases; Edema; Erythema; Female; Humans; Hyperhidrosis; Ibupr | 2011 |
Pharmacokinetics of intravenous ibuprofen: implications of time of infusion in the treatment of pain and fever.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Dose-Res | 2012 |
Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold.
Topics: Acetaminophen; Aspirin; Common Cold; Dyspepsia; Fever; Gastrointestinal Tract; Humans; Ibuprofen; No | 2012 |
Preoperative analgesics for additional pain relief in children and adolescents having dental treatment.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dental Care; Dental Care for Children; H | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Topical agents or dressings for pain in venous leg ulcers.
Topics: Administration, Topical; Analgesics; Anesthetics, Local; Bandages; Debridement; Humans; Ibuprofen; L | 2012 |
Ibuprofen blood plasma levels and onset of analgesia.
Topics: Adult; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Dose-Response Re | 2013 |
Optimising the management of fever and pain in children.
Topics: Acetaminophen; Analgesics; Child; Comparative Effectiveness Research; Dose-Response Relationship, Dr | 2013 |
A general overview of the use of ibuprofen in paediatrics.
Topics: Acute Disease; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Child; Chil | 2003 |
Review of the analgesic efficacy of ibuprofen.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Humans | 2003 |
Relative efficacy of selective COX-2 inhibitors compared with over-the-counter ibuprofen.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Ibuprofen | 2003 |
[Treatment for inflammation related pain--COX-2 inhibitors knocking on the door].
Topics: Acetaminophen; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibupr | 2004 |
Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Fever; Humans; Ibuprof | 2004 |
Acute pain: individual patient meta-analysis shows the impact of different ways of analysing and presenting results.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Ibuprofen; Lact | 2005 |
Oxycodone/Ibuprofen combination tablet: a review of its use in the management of acute pain.
Topics: Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Area Under Curve; Clinical Trials as To | 2005 |
Drugs for pain management in dentistry.
Topics: Acetaminophen; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Dental Care; Humans | 2005 |
Potential for drug-drug interactions in patients taking analgesics for mild-to-moderate pain and low-dose aspirin for cardioprotection.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cardiotonic Agents; Cardiovascular Diseases; Cyclo | 2006 |
Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Com | 2006 |
Myth: parenteral ketorolac provides more effective analgesia than oral ibuprofen.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Emergency Service, Hospital; Humans; | 2007 |
Why combine a foam dressing with ibuprofen for wound pain and moist wound healing?
Topics: Administration, Topical; Analgesics, Non-Narcotic; Bandages; Humans; Ibuprofen; Pain; Pain Managemen | 2007 |
Pain in persons with dementia: complex, common, and challenging.
Topics: Aged, 80 and over; Analgesics, Non-Narcotic; Dementia; Female; Geriatric Assessment; Humans; Ibuprof | 2007 |
New peripherally-acting oral analgesic agents.
Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials | 1983 |
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interact | 1980 |
Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Behavior, Animal; Brain; | 1995 |
Use of carprofen for the treatment of pain and inflammation in dogs.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1997 |
Non-NSAID pharmacologic treatment options for the management of chronic pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1998 |
Celecoxib clinical profile.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celec | 2000 |
Oxycodone/ibuprofen.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Drug Combinat | 2002 |
185 trials available for ibuprofen and Ache
| Article | Year |
|---|---|
The experience of pain in real-time during medication abortion.
Topics: Abortion, Induced; Acetaminophen; Analgesics; Analgesics, Opioid; Female; Humans; Ibuprofen; Mifepri | 2022 |
The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media.
Topics: Acetaminophen; Acute Disease; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Earache; H | 2022 |
Lack of Evidence for Blood Pressure Effects of Caffeine Added to Ibuprofen.
Topics: Analgesics, Non-Narcotic; Blood Pressure; Caffeine; Double-Blind Method; Humans; Ibuprofen; Pain; Pa | 2023 |
Effect of morphine and ibuprofen on nociceptive behavior, preening and motor activity following tonic chemical pain in the Japanese quail (Coturnix japonica).
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Coturnix; Fo | 2022 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Additive Value of Intranasal Fentanyl on Ibuprofen for Pain Management of Children With Moderate to Severe Headaches: A Randomized Controlled Trial.
Topics: Adolescent; Analgesics, Opioid; Child; Double-Blind Method; Fentanyl; Headache; Humans; Ibuprofen; P | 2023 |
Lack of Detection of the Analgesic Properties of PF-05089771, a Selective Na
Topics: Adolescent; Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Humans; | 2020 |
Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial.
Topics: Abortion, Induced; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Dronabinol; Female; Humans; | 2020 |
Comparative Assessment between Ibuprofen, Chewing Gum, and Bite Wafers in Pain Control Following First Archwire Placement in Orthodontic Patients.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Chewing Gum; Female; Humans; Ibuprofen; Orthodontic Wir | 2020 |
Ibuprofen in needle procedures in children with cancer-A feasibility and pilot study.
Topics: Child; Feasibility Studies; Humans; Ibuprofen; Neoplasms; Pain; Pilot Projects | 2021 |
Non-steroidal or opioid analgesia use for children with musculoskeletal injuries (the No OUCH study): statistical analysis plan.
Topics: Analgesia; Analgesics, Opioid; Child; Double-Blind Method; Humans; Ibuprofen; Pain; Pain Management | 2020 |
Effects of ibuprofen and low-level laser therapy on orthodontic pain by means of the analysis of interleukin 1-beta and substance P levels in the gingival crevicular fluid.
Topics: Gingival Crevicular Fluid; Humans; Ibuprofen; Interleukin-1beta; Low-Level Light Therapy; Pain; Pain | 2021 |
Opioid prescription for pain after osmotic dilator placement in abortion care: A randomized controlled trial.
Topics: Analgesics, Opioid; Double-Blind Method; Female; Humans; Ibuprofen; Oxycodone; Pain; Pain, Postopera | 2021 |
Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Female; Hu | 2021 |
Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol.
Topics: Acetaminophen; Asthma; Child; Child, Preschool; Humans; Ibuprofen; Infant; Infant, Newborn; Multicen | 2020 |
Influence of Genetic Polymorphisms on the Response to Tramadol, Ibuprofen, and the Combination in Patients With Moderate to Severe Pain After Dental Surgery.
Topics: Analgesics, Opioid; Double-Blind Method; Humans; Ibuprofen; Pain; Pain, Postoperative; Polymorphism, | 2021 |
Evaluation of the effect of Elaeagnus angustifolia alone and combined with Boswellia thurifera compared with ibuprofen in patients with knee osteoarthritis: a randomized double-blind controlled clinical trial.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Boswellia; Double-Blind Method; Elaeagna | 2017 |
Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: An open-label randomized controlled trial.
Topics: Adalimumab; Aged; Antirheumatic Agents; Celecoxib; Diclofenac; Female; Humans; Hyaluronic Acid; Ibup | 2018 |
Efficacy and safety assessment of acute sports-related traumatic soft tissue injuries using a new ibuprofen medicated plaster: results from a randomized controlled clinical trial.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Area Under Curve; Athletic Injuries; Casts, Surgical; C | 2017 |
Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: Single centre double-blind, randomised controlled clinical trial.
Topics: Acetaminophen; Administration, Oral; Analgesics; Double-Blind Method; Female; Humans; Ibuprofen; Inf | 2018 |
Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2018 |
[In process].
Topics: Acetaminophen; Asthma; Child, Preschool; Disease Progression; Fever; Humans; Ibuprofen; Pain; Prospe | 2016 |
A randomized, single-blind, placebo-controlled trial to evaluate the effectiveness of verbal behavior modification and acetaminophen on orthodontic pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Behavior Therapy; Double-Blind Method; Humans; Ibuprofen; P | 2019 |
Effects of pre-emptive analgesia on efficacy of buccal infiltration during pulpotomy of mandibular primary molars: a double-blinded randomized controlled trial.
Topics: Acetaminophen; Analgesia; Child; Double-Blind Method; Humans; Ibuprofen; Molar; Pain; Pulpotomy; Too | 2019 |
Comparison of diclofenac gel, ibuprofen gel, and ibuprofen gel with levomenthol for the topical treatment of pain associated with musculoskeletal injuries.
Topics: Administration, Topical; Adolescent; Adult; Aged; Diclofenac; Female; Gels; Humans; Ibuprofen; Male; | 2019 |
Effects of various analgesics on the level of prostaglandin E2 during orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dinoprostone; Double-Blind Method; Femal | 2014 |
Percutaneous pin removal in the outpatient clinic--do children require analgesia?: a randomized controlled trial.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Bone Nails; Child; Child, Preschool; | 2014 |
Evaluation of pain in office hysteroscopy with prior analgesic medication: a prospective randomized study.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesics; Female; H | 2014 |
Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Double-Blind Method; Fema | 2014 |
Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Double-Blind Method; Fema | 2014 |
Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Double-Blind Method; Fema | 2014 |
Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Double-Blind Method; Fema | 2014 |
Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial.
Topics: Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibupr | 2015 |
Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial.
Topics: Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibupr | 2015 |
Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial.
Topics: Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibupr | 2015 |
Prophylactic ibuprofen does not improve pain with IUD insertion: a randomized trial.
Topics: Adolescent; Adult; Age Factors; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibupr | 2015 |
The shortened infusion time of intravenous ibuprofen part 1: a multicenter, open-label, surveillance trial to evaluate safety and efficacy.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Double-Blin | 2015 |
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose- | 2016 |
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose- | 2016 |
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose- | 2016 |
Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain.
Topics: Acetaminophen; Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose- | 2016 |
SWIM (sickle with ibuprofen and morphine) randomised controlled trial fails to recruit: lessons learnt.
Topics: Administration, Oral; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anemia, Sickle Cell; | 2016 |
Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Female; Humans; Ibuprofen | 2016 |
Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.
Topics: Acetaminophen; Asthma; Child, Preschool; Double-Blind Method; Female; Fever; Humans; Ibuprofen; Inci | 2016 |
Two prophylactic medication approaches in addition to a pain control regimen for early medical abortion < 63 days' gestation with mifepristone and misoprostol: study protocol for a randomized, controlled trial.
Topics: Abortifacient Agents, Nonsteroidal; Abortifacient Agents, Steroidal; Abortion, Induced; Adolescent; | 2016 |
Pain Reduction in Untreated Symptomatic Irreversible Pulpitis Using Liposomal Bupivacaine (Exparel): A Prospective, Randomized, Double-blind Trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Dental; Anesthesia, | 2016 |
Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthriti | 2017 |
Efficacy of celecoxib versus ibuprofen for the treatment of patients with osteoarthritis of the knee: A randomized double-blind, non-inferiority trial.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; C | 2017 |
Chewing gum vs. ibuprofen in the management of orthodontic pain, a multi-centre randomised controlled trial - the effect of anxiety.
Topics: Adolescent; Anxiety; Chewing Gum; Child; Humans; Ibuprofen; Pain; Societies, Dental | 2017 |
Combined use of an ibuprofen-releasing foam dressing and silver dressing on infected leg ulcers.
Topics: Aged; Anti-Infective Agents, Local; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparat | 2008 |
Anti-TNF-alpha treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Double-Blind Method; Endometrio | 2008 |
Premedication to reduce discomfort during screening mammography.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen | 2008 |
Prospective double-blind crossover trial of ibuprofen in reducing EMG pain.
Topics: Adult; Analgesics, Non-Narcotic; Cross-Over Studies; Double-Blind Method; Electromyography; Female; | 2008 |
Effect of an ibuprofen-releasing foam dressing on wound pain: a real-life RCT.
Topics: Activities of Daily Living; Aged; Anti-Inflammatory Agents, Non-Steroidal; Exudates and Transudates; | 2008 |
ADIDAC trial: analgesia with dexibuprofen versus ibuprofen in patients suffering from primary dysmenorrhea: a crossover trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Dose-Response Relationship, Drug | 2009 |
Tamsulosin for ureteral stones in the emergency department: a randomized, controlled trial.
Topics: Adrenergic alpha-Antagonists; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Dr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Comparison of the efficacy of ibuprofen and acetaminophen in controlling pain after orthodontic tooth movement.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Female; Follow-Up Studies; Humans; Ibupr | 2009 |
Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Co | 2009 |
Randomized double-blind placebo controlled crossover study of acetaminophen, ibuprofen, acetaminophen/hydrocodone, and placebo for the relief of pain from a standard painful stimulus.
Topics: Acetaminophen; Acute Disease; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Combinations | 2009 |
Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis.
Topics: Aged; Curcuma; Female; Humans; Ibuprofen; Knee Joint; Male; Middle Aged; Osteoarthritis, Knee; Pain; | 2009 |
Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cartilage Oligomeric Matrix Protein; Cart | 2010 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain.
Topics: Acetaminophen; Adolescent; Analgesics; Arm Injuries; Child; Child, Preschool; Codeine; Double-Blind | 2009 |
Effects of preoperative ibuprofen on pain after separator placement.
Topics: Adolescent; Adult; Affect; Analgesics, Non-Narcotic; Anxiety; Attitude to Health; Dental Occlusion; | 2009 |
A comparison of migraine patients with and without allodynic symptoms.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Asian People; Double-Blind Method; Femal | 2009 |
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non | 2009 |
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non | 2009 |
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non | 2009 |
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non | 2009 |
Effects of ibuprofen topical gel on muscle soreness.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Elbow; Female; Gels; Huma | 2010 |
Paracetamol versus ibuprofen: a randomized controlled trial of outpatient analgesia efficacy for paediatric acute limb fractures.
Topics: Acetaminophen; Acute Disease; Adolescent; Ambulatory Care; Analgesics, Non-Narcotic; Analysis of Var | 2009 |
...And what's best for fracture pain in children?
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Codeine; Drug Combin | 2009 |
Paracetamol/codeine probably had equivalent analgesia to ibuprofen in children with extremity injuries.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Co | 2010 |
Effects of superpulsed low-level laser therapy on temporomandibular joint pain.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Ibu | 2010 |
The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis.
Topics: Adult; Analysis of Variance; Anesthesia, Dental; Anesthetics, Local; Anti-Inflammatory Agents, Non-S | 2010 |
Pain management in young children undergoing diagnostic tympanocentesis.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Biopsy, Fine-Needle; Chi | 2011 |
Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model.
Topics: Acetaminophen; Adolescent; Adult; Anesthesia, Dental; Anti-Inflammatory Agents, Non-Steroidal; Codei | 2011 |
Effects of analgesics on orthodontic pain.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2011 |
Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat | 2011 |
[Application of a seven-day buprenorphine transdermal patch in multimorbid patients on long-term ibuprofen or diclofenac].
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, No | 2011 |
A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chronic Disease; Dose-Respo | 2011 |
Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Glucosamine; Humans; Ibu | 2011 |
Pre-emptive effect of ibuprofen versus placebo on pain relief and success rates of medical abortion: a double-blind, randomized, controlled study.
Topics: Abortifacient Agents, Nonsteroidal; Abortifacient Agents, Steroidal; Abortion, Induced; Administrati | 2012 |
Pain reduction after initial archwire placement in orthodontic patients: a randomized clinical trial.
Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bite Force; Chewing G | 2012 |
Pain reduction after initial archwire placement in orthodontic patients: a randomized clinical trial.
Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bite Force; Chewing G | 2012 |
Pain reduction after initial archwire placement in orthodontic patients: a randomized clinical trial.
Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bite Force; Chewing G | 2012 |
Pain reduction after initial archwire placement in orthodontic patients: a randomized clinical trial.
Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bite Force; Chewing G | 2012 |
Sex differences in analgesic response to ibuprofen are influenced by expectancy: a randomized, crossover, balanced placebo-designed study.
Topics: Adolescent; Adult; Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Electric | 2012 |
A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Dalte | 2012 |
The effect of electroacupuncture and tramadol on experimental tourniquet pain.
Topics: Acupuncture Points; Adult; Analgesia; Analysis of Variance; Electric Stimulation; Electroacupuncture | 2012 |
Responsiveness of the OARSI-OMERACT osteoarthritis pain and function measures.
Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Disability Evaluation; Doub | 2012 |
Aggravation of exercise-induced intestinal injury by Ibuprofen in athletes.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Athletes; Bicycling; Biomarkers; Fatty Acid-Binding | 2012 |
Characteristics and clinical implications of the pharmacokinetic profile of ibuprofen in patients with knee osteoarthritis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Dose-Response R | 2012 |
Efficacy of an ibuprofen/codeine combination for pain management in children presenting to the emergency department with a limb injury: a pilot study.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Codeine; Contusions; | 2013 |
Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over | 2002 |
Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.
Topics: Adolescent; Adult; Analysis of Variance; Bromelains; Dose-Response Relationship, Drug; Double-Blind | 2002 |
Comparative efficacy of a proprietary topical ibuprofen gel and oral ibuprofen in acute soft tissue injuries: a randomized, double-blind study.
Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-St | 2002 |
Tolerability of ibuprofen, aspirin and paracetamol for the treatment of cold and flu symptoms and sore throat pain.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Co | 2002 |
A randomized, clinical trial comparing oral celecoxib 200 mg, celecoxib 400 mg, and ibuprofen 600 mg for acute pain.
Topics: Acute Disease; Adult; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double | 2003 |
The effects of ibuprofen on delayed muscle soreness and muscular performance after eccentric exercise.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatine Kinase; Double-Blind Method; Exercise; Fema | 2003 |
Prior ibuprofen exposure does not augment opioid drug potency or modify opioid requirements for pain inhibition in total hip surgery.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Blood L | 2003 |
A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Drug Administration | 2003 |
Use of a simple pain model to evaluate analgesic activity of ibuprofen versus paracetamol.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Male | 2000 |
Analgesic efficacy of non-steroidal anti-inflammatory drugs in experimental pain in humans.
Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curv | 1993 |
Short report: ibuprofen versus glucosamine sulfate. Treating osteoarthritis pain.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Gl | 2003 |
Corticosteroids, ibuprofen, and acetaminophen for IFNbeta-1a flu symptoms in MS: a randomized trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Asthenia; Chills; Double-Blind Method; Drug Administ | 2004 |
A randomized open label study of pain medications (naproxen, acetaminophen and ibuprofen) for controlling side effects during initiation of IFN beta-1a therapy and during its ongoing use for relapsing-remitting multiple sclerosis.
Topics: Acetaminophen; Adjuvants, Immunologic; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, No | 2004 |
A large simple clinical trial prototype for assessment of OTC drug effects using patient-reported data.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Aspirin; Female; Humans; Ibuprofen; Male; Middle | 2005 |
The effect of topical non-steroidal anti-inflammatory cream on the incidence and severity of cutaneous burns following external DC cardioversion.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Burns, Electric; Double-Bli | 2005 |
The isolated and combined effects of selected physical activity and ibuprofen on delayed-onset muscle soreness.
Topics: Adult; Analgesics, Non-Narcotic; Athletic Injuries; Combined Modality Therapy; Creatine Kinase; Elbo | 2005 |
TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care: a randomised controlled trial with patient preference study. [ISRCTN79353052].
Topics: Administration, Oral; Administration, Topical; Analgesics, Non-Narcotic; Chronic Disease; Cost-Benef | 2005 |
Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheria-tetanus toxoids-acellular pertussis vaccination: a randomized, controlled trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres | 2006 |
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human | 2006 |
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human | 2006 |
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human | 2006 |
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human | 2006 |
Cobrotoxin-containing analgesic compound to treat chronic moderate to severe cancer pain: results from a randomized, double-blind, cross-over study and from an open-label study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Cobra Neurotoxin Proteins; Cross-Over Studies; Double-Bl | 2006 |
Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain.
Topics: Acute Disease; Adolescent; Adult; Anti-Inflammatory Agents; Cyclooxygenase 2 Inhibitors; Cytokines; | 2007 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen.
Topics: Adult; Aging; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Intrauterine | 2006 |
Randomized controlled trial comparing Thermachoice III* in the outpatient versus daycase setting.
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia, General; Catheter Ablation; Catheterization; Endo | 2007 |
Pain catastrophizing, response to experimental heat stimuli, and post-cesarean section pain.
Topics: Adult; Analgesics, Non-Narcotic; Cesarean Section; Female; Hot Temperature; Humans; Ibuprofen; Pain; | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma.
Topics: Acetaminophen; Acute Disease; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analgesics | 2007 |
A pilot (real-life) randomised clinical evaluation of a pain-relieving foam dressing: (ibuprofen-foam versus local best practice).
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Bandages; Chronic | 2007 |
Less pain with Biatain-Ibu: initial findings from a randomised, controlled, double-blind clinical investigation on painful venous leg ulcers.
Topics: Administration, Topical; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Bandages; Double-Blind M | 2007 |
[Efficacy of ibuprofen (nurofen gel) ultraphonophoresis for pain relief in osteoarthrosis].
Topics: Administration, Cutaneous; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Administration | 2007 |
Effectiveness of oxycodone, ibuprofen, or the combination in the initial management of orthopedic injury-related pain in children.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Ch | 2007 |
Effectiveness of oxycodone, ibuprofen, or the combination in the initial management of orthopedic injury-related pain in children.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Ch | 2007 |
Effectiveness of oxycodone, ibuprofen, or the combination in the initial management of orthopedic injury-related pain in children.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Ch | 2007 |
Effectiveness of oxycodone, ibuprofen, or the combination in the initial management of orthopedic injury-related pain in children.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Ch | 2007 |
Influences on older people's decision making regarding choice of topical or oral NSAIDs for knee pain: qualitative study.
Topics: Administration, Oral; Administration, Topical; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Age | 2008 |
Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study.
Topics: Administration, Oral; Administration, Topical; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Age | 2008 |
A randomized trial of tramadol versus ibuprofen as an adjunct to pain control during vacuum aspiration abortion.
Topics: Abortion, Therapeutic; Adult; Analgesics; Female; Humans; Ibuprofen; Pain; Pregnancy; Tramadol; Trea | 2008 |
Rapidly dissolving formulations for quick absorption during pain episodes: ibuprofen.
Topics: Absorption; Administration, Oral; Adult; Analgesics, Non-Narcotic; Animals; Area Under Curve; Drug D | 2008 |
Ibuprofen and paracetamol for pain relief during medical abortion: a double-blind randomized controlled study.
Topics: Abortion, Induced; Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Age | 2009 |
[Influence of adjuvant pain medication on quality of life in the treatment of postmenopausal osteoporosis].
Topics: Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Chemotherapy, Adjuvant; Female; Humans; Ibuprofe | 2008 |
Ibuprofen and compression bandage in the treatment of ankle sprains.
Topics: Adult; Ankle Injuries; Bandages; Clinical Trials as Topic; Edema; Female; Humans; Ibuprofen; Male; P | 1983 |
New peripherally-acting oral analgesic agents.
Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials | 1983 |
Comparison of suprofen and ibuprofen in the treatment of pain secondary to osteoarthritis.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ibuprofen; M | 1983 |
Sulindac versus ibuprofen in sprains and strains.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Humans; Ibuprofen; Indenes; Male; | 1984 |
Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; I | 1984 |
A multi-centre general practice study evaluating the efficacy and tolerance of ibuprofen in common painful conditions.
Topics: Administration, Oral; Adolescent; Adult; Aged; Clinical Trials as Topic; Female; Humans; Ibuprofen; | 1984 |
Differential efficacy of two non-steroidal anti-inflammatory drugs in the treatment of sports injuries.
Topics: Adult; Anti-Inflammatory Agents; Athletic Injuries; Female; Humans; Ibuprofen; Indenes; Male; Pain; | 1984 |
Short-term treatment of osteoarthritis: a comparison of sodium meclofenamate and ibuprofen.
Topics: Aged; Anti-Inflammatory Agents; Female; Hip Joint; Humans; Ibuprofen; Knee Joint; Male; Meclofenamic | 1982 |
Response of pathological ischaemic muscle pain to analgesics.
Topics: Aged; Analgesics; Female; Humans; Ibuprofen; Indoprofen; Ischemia; Male; Middle Aged; Muscles; Muscu | 1980 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Pain control in abortion.
Topics: Abortion, Therapeutic; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Ibuprof | 1995 |
Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; | 1995 |
Quantitative assessment of joint pain following treatment of rheumatoid arthritis with ibuprofen cream.
Topics: Administration, Topical; Arthritis, Rheumatoid; Double-Blind Method; Humans; Ibuprofen; Middle Aged; | 1994 |
Evaluation of topical ibuprofen cream in the treatment of acute ankle sprains.
Topics: Administration, Topical; Adolescent; Adult; Ankle Injuries; Double-Blind Method; Emergency Service, | 1994 |
Dose-related effects of ibuprofen on pain-related potentials.
Topics: Adult; Carbon Dioxide; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography | 1994 |
Effect of ibuprofen use on muscle soreness, damage, and performance: a preliminary investigation.
Topics: Adolescent; Adult; Biomechanical Phenomena; Creatine Kinase; Double-Blind Method; Electromyography; | 1993 |
A placebo-controlled model for assaying systemic analgesics in children.
Topics: Acetaminophen; Child; Child, Preschool; Double-Blind Method; Female; Humans; Ibuprofen; Male; Pain; | 1993 |
Comparative efficacy of diclofenac dispersible 50 mg and ibuprofen 400 mg in patients with primary dysmenorrhea. A randomized, double-blind, within-patient, placebo-controlled study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Double-B | 1995 |
Stereoselective disposition of ibuprofen enantiomers in human cerebrospinal fluid.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Ibuprofen; Male; Middle Aged; Pain; Spinal Punctu | 1995 |
Topical ibuprofen for skin analgesia prior to venepuncture.
Topics: Administration, Topical; Analgesia; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Cat | 1996 |
Ibuprofen and diclofenac sodium in the treatment of osteoarthritis: a comparative trial of two once-daily sustained-release NSAID formulations.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 1996 |
The effect of nitrous oxide and carbon dioxide pneumoperitoneum on operative and postoperative pain during laparoscopic sterilization under local anesthesia.
Topics: Administration, Oral; Adult; Alfentanil; Analgesia; Analgesics, Opioid; Anesthesia, Local; Anestheti | 1994 |
Comparison of the antinociception produced by two oral formulations of ibuprofen: ibuprofen effervescent vs ibuprofen tablets.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Con | 1997 |
The negative mucosal potential: separating central and peripheral effects of NSAIDs in man.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Brain; Carbon Dioxide; Chemoreceptor Cells; Cross-Ov | 1997 |
Intramuscular ketorolac vs oral ibuprofen in emergency department patients with acute pain.
Topics: Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Metho | 1998 |
Efficacy of analgesics in chronic pain: a series of N-of-1 studies.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Codeine; Female | 1998 |
Efficacy of analgesics in chronic pain: a series of N-of-1 studies.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Codeine; Female | 1998 |
Efficacy of analgesics in chronic pain: a series of N-of-1 studies.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Codeine; Female | 1998 |
Efficacy of analgesics in chronic pain: a series of N-of-1 studies.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Codeine; Female | 1998 |
Efficacy of analgesics in chronic pain: a series of N-of-1 studies.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Codeine; Female | 1998 |
Efficacy of analgesics in chronic pain: a series of N-of-1 studies.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Codeine; Female | 1998 |
Efficacy of analgesics in chronic pain: a series of N-of-1 studies.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Codeine; Female | 1998 |
Efficacy of analgesics in chronic pain: a series of N-of-1 studies.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Codeine; Female | 1998 |
Efficacy of analgesics in chronic pain: a series of N-of-1 studies.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Codeine; Female | 1998 |
Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen.
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cross- | 1998 |
Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model.
Topics: Adult; Analgesics, Non-Narcotic; Animals; CHO Cells; Cricetinae; Cyclooxygenase Inhibitors; Dinopros | 1999 |
Pain-mediated altered absorption and metabolism of ibuprofen: an explanation for decreased serum enantiomer concentration after dental surgery.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Epinephrine; Female; Gastric Emptying; Humans; Ibupr | 1999 |
Combination hydrocodone and ibuprofen versus combination codeine and acetaminophen for the treatment of chronic pain.
Topics: Acetaminophen; Adult; Aged; Analgesics; Chronic Disease; Codeine; Double-Blind Method; Drug Therapy, | 2000 |
Plasma levels after peroral and topical ibuprofen and effects upon low pH-induced cutaneous and muscle pain.
Topics: Acidosis; Acids; Administration, Cutaneous; Administration, Oral; Adult; Anti-Inflammatory Agents, N | 2000 |
Patients' perceptions of route of nonsteroidal anti-inflammatory drug administration and its effect on analgesia.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Emergency | 2000 |
The effect of standard care, ibuprofen, and music on pain relief and patient satisfaction in adults with musculoskeletal trauma.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Nursing Research; Combined Modality Therapy | 2001 |
Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroid | 2001 |
Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Glucosamine; Humans; Ib | 2001 |
The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain.
Topics: Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2001 |
The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain.
Topics: Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2001 |
The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain.
Topics: Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2001 |
The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain.
Topics: Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2001 |
The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain.
Topics: Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2001 |
The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain.
Topics: Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2001 |
The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain.
Topics: Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2001 |
The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain.
Topics: Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2001 |
The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain.
Topics: Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2001 |
Endoscopic evaluation of the gastrotolerance of short-term antalgic treatment with low dose k-diclofenac: a comparison of ibuprofen and aspirin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Duodenum; Endoscopy, Gastrointe | 2001 |
Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Glucosamine; Hum | 1994 |
Ibuprofen versus acetaminophen with codeine for the relief of perineal pain after childbirth: a randomized controlled trial.
Topics: Acetaminophen; Adult; Analgesics; Codeine; Delivery, Obstetric; Double-Blind Method; Episiotomy; Fem | 2001 |
Efficacy and long-term safety of dexibuprofen [S(+)-ibuprofen]: a short-term efficacy study in patients with osteoarthritis of the hip and a 1-year tolerability study in patients with rheumatic disorders.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Humans; Ibuprofen; Isomer | 2001 |
Efficacy of a proprietary ibuprofen gel in soft tissue injuries: a randomised, double-blind, placebo-controlled study.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-S | 2002 |
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Tri | 1976 |
Comparison of benorylate and ibuprofen in the treatment of established rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Hand; Humans; Ibuprofen; Pain; Propionates; Salicyl | 1975 |
Ibuprofen in osteoarthritis.
Topics: Activities of Daily Living; Aspirin; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Dextro | 1977 |
A double-blind trial of feprazone in osteoarthritis of the hip.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Feprazone; Hip Joint; Humans; Ibuprofen | 1977 |
Indoprofen versus ibuprofen in osteoarthrosis: a short-term, double-blind, crossover trial.
Topics: Adult; Aged; Bone Diseases; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ibuprofen | 1979 |
A comparative clinical trial of diflunisal and ibuprofen in the control of pain in osteoarthritis.
Topics: Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Hip Joint; Humans; Ibuprofen; Kne | 1979 |
Four new anti-inflammatory drugs: responses and variations.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Fenoprofen; Gastrointesti | 1976 |
A six-month double-blind trial of ibuprofen and indomethacin in osteoarthritis.
Topics: Adult; Central Nervous System; Clinical Trials as Topic; Digestive System; Female; Humans; Ibuprofen | 1975 |
Ibuprofen versus buffered phenylbutazone in the treatment of osteoarthritis: double-blind trial.
Topics: Alanine Transaminase; Clinical Trials as Topic; Drug Evaluation; Humans; Ibuprofen; Osteoarthritis; | 1975 |
Ibuprofen plus codeine, ibuprofen, and placebo in a single- and multidose cross-over comparison for coxarthrosis pain.
Topics: Adult; Aged; Codeine; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; | 1992 |
The relationship between pain and uterine contractions during laser vaporization of the cervix.
Topics: Cervix Uteri; Double-Blind Method; Female; Humans; Ibuprofen; Laser Therapy; Pain; Pain Measurement; | 1992 |
Comparison of two ibuprofen formulations in the treatment of shoulder tendonitis.
Topics: Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Denmark; Double-Blind Method; Female; H | 1992 |
Activity and pharmacokinetics of a new oral dosage form of soluble ibuprofen.
Topics: Adult; Aged; Arginine; Biological Availability; Double-Blind Method; Female; Humans; Ibuprofen; Male | 1992 |
Randomized, double-blind, multicenter, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children.
Topics: Acetaminophen; Administration, Oral; Child; Deglutition; Double-Blind Method; Drug Tolerance; Female | 1991 |
Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam. A double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Alprazolam; Depression; Double-Blind Method; Fibromyalgia; Humans; Ibuprofe | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee.
Topics: Acetaminophen; Chronic Disease; Double-Blind Method; Female; Humans; Ibuprofen; Knee Joint; Locomoti | 1991 |
Effects of ibuprofen on exercise-induced muscle soreness and indices of muscle damage.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Creatine Kinase; Creatinine; Humans; Ibuprofen; L-La | 1990 |
A double-blind, placebo controlled, cross-over comparison of the analgesic effect of ibuprofen 400 mg and 800 mg on laser-induced pain.
Topics: Administration, Oral; Adult; Analgesia; Dose-Response Relationship, Drug; Double-Blind Method; Femal | 1990 |
The combination of ibuprofen and oxycodone/acetaminophen in the management of chronic cancer pain.
Topics: Acetaminophen; Adult; Aged; Analysis of Variance; Bone Neoplasms; Chronic Disease; Codeine; Double-B | 1988 |
Codeine 20 mg increases pain relief from ibuprofen 400 mg after third molar surgery. A repeat-dosing comparison of ibuprofen and an ibuprofen-codeine combination.
Topics: Adult; Codeine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Hu | 1989 |
Ibuprofen and naproxen-sodium in the treatment of primary dysmenorrhea: a double-blind cross-over study.
Topics: Adolescent; Adult; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Naproxen; Pain | 1985 |
Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Ketop | 1988 |
Morphine and ibuprofen compared using the cold pressor test.
Topics: Adult; Analgesics; Cold Temperature; Double-Blind Method; Female; Humans; Ibuprofen; Male; Middle Ag | 1988 |
Sore throat pain in the evaluation of mild analgesics.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics; Double-Blind Method; Drug Evaluation; Fem | 1988 |
A double-blind, placebo-controlled study comparing three single-dose regimens of piroxicam with ibuprofen in patients with primary dysmenorrhea.
Topics: Abdomen; Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Drug Administration Sched | 1988 |
Efficacy and safety of an ibuprofen and dextropropoxyphene combination (Ibudex) in medical practice.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Dextropropoxyphene; Drug Combinations; Female; Hu | 1986 |
Nabumetone in the treatment of skin and soft tissue injury.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butano | 1987 |
Effect of ibuprofen on isometric contractions and associated pain of the human masseter muscle.
Topics: Adult; Electromyography; Female; Humans; Ibuprofen; Isometric Contraction; Male; Masseter Muscle; Ma | 1987 |
The correlation between blood levels of ibuprofen and clinical analgesic response.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Humans; I | 1986 |
A double-blind study comparing ibuprofen 1800 mg or 2400 mg daily and placebo in sports injuries.
Topics: Adolescent; Adult; Athletic Injuries; Clinical Trials as Topic; Double-Blind Method; Female; Humans; | 1986 |
Ibuprofen in rheumatoid arthritis. Clinical study of analgesic and anti-inflammatory activity.
Topics: Adult; Aged; Alanine Transaminase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Aspirin; Doub | 1968 |
219 other studies available for ibuprofen and Ache
| Article | Year |
|---|---|
Nonsteroidal antiinflammatory agents. 1. 5-Alkoxy-3-biphenylylacetic acids and related compounds as new potential antiinflammatory agenst.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compo | 1977 |
Nonsteroidal antiinflammatory agents. 2. [(Heteroarylamino)phenyl]alkanoic acids.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carboxylic Acids; Carrageenan; Edema; Fe | 1983 |
Synthesis, pharmacological activity and hydrolytic behavior of ethylenediamine and benzathine conjugates of ibuprofen.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dis | 2008 |
Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspergillus; Edema; Esch | 2009 |
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular | 2013 |
Antinociceptive Grayanoids from the Roots of Rhododendron molle.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Diterpenes; Drugs, | 2015 |
Design, synthesis and biological evaluation of novel analgesic agents targeting both cyclooxygenase and TRPV1.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Body Temperature; Capsaicin; Cyclooxygenase | 2016 |
Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.
Topics: Animals; Drug Discovery; Humans; Ligands; Molecular Docking Simulation; Pain; Protein Conformation; | 2018 |
The discovery of novel 3-aryl-indazole derivatives as peripherally restricted pan-Trk inhibitors for the treatment of pain.
Topics: Dose-Response Relationship, Drug; Drug Discovery; Humans; Indazoles; Molecular Structure; Pain; Prot | 2019 |
Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.
Topics: Animals; Carboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; | 2019 |
Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbonic Anhydrase Inhibito | 2020 |
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2020 |
Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: Lead optimization studies toward their analgesic efficacy for inflammatory pain.
Topics: Analgesics; Animals; Anoctamin-1; Carboxylic Acids; HEK293 Cells; Humans; Hyperalgesia; Mice; Neopla | 2022 |
Pharmacodynamic/pharmacokinetic correlation of optimized ibuprofen nanosuspensions having enhanced anti-inflammatory and antinociceptive activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Disease Models, Anim | 2022 |
Design and synthesis of ibuprofen-quinoline conjugates as potential anti-inflammatory and analgesic drug candidates.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cycloox | 2022 |
Comparison table: Some nonopioid analgesics for pain.
Topics: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Pa | 2022 |
Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers.
Topics: Acetaminophen; Administration, Oral; Adult; Biological Availability; Body Composition; Body Weight; | 2022 |
Quantifying the intensity of adverse events with ibuprofen and oxycodone: an observational cohort study.
Topics: Analgesics, Opioid; Child; Cohort Studies; Constipation; Double-Blind Method; Fractures, Bone; Human | 2022 |
Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Feeding Beh | 2022 |
Standardized Centella asiatica (ECa 233) extract decreased pain hypersensitivity development in a male mouse model of chronic inflammatory temporomandibular disorder.
Topics: Analgesics; Animals; Centella; Disease Models, Animal; Freund's Adjuvant; Hypersensitivity; Ibuprofe | 2023 |
Oral Nonprescription Pain Medications for Adults.
Topics: Administration, Oral; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; | 2023 |
Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception.
Topics: Acetaminophen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase | 2019 |
Anti-rheumatic activity of Phenethyl isothiocyanate via inhibition of histone deacetylase-1.
Topics: Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumat | 2020 |
Pain during medical abortion in early pregnancy in teenage and adult women.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Acetaminophen; Adolescent; Adult; Analgesics; | 2020 |
Association Between Male Use of Pain Medication and Fecundability.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Birth Rate; Cohort Studies; | 2020 |
Synthesis of new ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygena | 2020 |
Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease Models, Animal; Dos | 2021 |
Butyl methyl imidazolium silica sulfate (BMIm)SS: A novel hybrid nano-catalyst for highly efficient synthesis of new 1,2-diol monoesters of ibuprofen as the novel prodrugs of ibuprofen having potent analgesic property.
Topics: Analgesics; Animals; Binding Sites; Catalysis; Catalytic Domain; Cyclooxygenase 2; Esters; Female; I | 2021 |
New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Surviva | 2021 |
Paracetamol or ibuprofen for fever or pain in children under 2 years old.
Topics: Acetaminophen; Antipyretics; Child; Fever; Humans; Ibuprofen; Infant; Pain | 2021 |
Assessment of pharmacological activities of Lygodium microphyllum Cav. leaves in the management of pain, inflammation, pyrexia, diarrhea, and helminths: In vivo, in vitro and in silico approaches.
Topics: Albendazole; Analgesics; Animals; Anthelmintics; Anti-Inflammatory Agents; Antidiarrheals; Antipyret | 2021 |
Effectiveness of conservative interventions for sickness and pain behaviors induced by a high repetition high force upper extremity task.
Topics: Aggression; Analgesics, Non-Narcotic; Animals; Biomarkers; Brain; Conservative Treatment; Cumulative | 2017 |
Decreased alertness due to sleep loss increases pain sensitivity in mice.
Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Chronic Diseas | 2017 |
Synergistic analgesic, anti-pyretic and anti-inflammatory effects of extra virgin olive oil and ibuprofen in different experimental models of albino mice.
Topics: Acetic Acid; Albinism; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Carrageenan; Din | 2017 |
Use of multicriteria decision analysis for assessing the benefit and risk of over-the-counter analgesics.
Topics: Analgesics; Aspirin; Decision Support Techniques; Gastrointestinal Diseases; Humans; Ibuprofen; Napr | 2017 |
NSAIDs relieve osteoarthritis (OA) pain, but cardiovascular safety in question even for diclofenac, ibuprofen, naproxen, and celecoxib: what are the alternatives?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Diclofenac; Humans; Ibuprofen; Naproxen; Network | 2017 |
No trustworthy evidence about the effectiveness of laser therapy or ibuprofen to minimize pain during orthodontic treatment with fixed appliances owing to major limitations in the process to conduct a systematic review.
Topics: Humans; Ibuprofen; Low-Level Light Therapy; Orthodontic Appliances, Fixed; Pain; Randomized Controll | 2017 |
Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Diseas | 2018 |
Pain Treatment Practices of Community-Dwelling Black Older Adults.
Topics: Aged; Anthropology, Cultural; Black or African American; Codeine; Exercise Therapy; Faith Healing; F | 2018 |
Exceeding the daily dosing limit of nonsteroidal anti-inflammatory drugs among ibuprofen users.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Female; Humans; Ib | 2018 |
Effect of Ibuprofen on Muscle, Hematological and Renal Function, Hydric Balance, Pain, and Performance During Intense Long-Distance Running.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Athletic Performance; Environmental Biomarkers; Hear | 2020 |
Morphine is not superior to ibuprofen for managing children's pain following minor orthopedic surgery.
Topics: Child; Double-Blind Method; Humans; Ibuprofen; Morphine; Orthopedics; Pain; Pain Management | 2018 |
Acupuncture seems to result in a higher reduction in pain compared with a single 400 milligram dose of ibuprofen in patients with irreversible pulpitis.
Topics: Acupuncture Therapy; Double-Blind Method; Humans; Ibuprofen; Pain; Pain Management; Pulpitis | 2018 |
Pain in children remains an unsolved problem.
Topics: Acetaminophen; Child; Emergency Service, Hospital; Humans; Ibuprofen; Pain | 2018 |
Pain relief: determining the safety of ibuprofen with postpartum preeclampsia.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Hypertension; Ibuprofe | 2018 |
There seems to be similar improvement in pain and mouth opening limitation when comparing glucosamine supplements with a placebo or ibuprofen in patients with temporomandibular joint osteoarthritis.
Topics: Glucosamine; Humans; Ibuprofen; Mouth; Osteoarthritis; Pain; Temporomandibular Joint | 2018 |
Walking hyponatremia syndrome of inappropriate antidiuretic hormone secretion secondary to carbamazepine use: a case report.
Topics: Adult; Ambulatory Care; Analgesics, Non-Narcotic; Animals; Carbamazepine; Cattle; Female; Humans; Hy | 2018 |
Combining morphine and ibuprofen does not improve pain control compared with using either drug alone following musculoskeletal injury in children.
Topics: Analgesics; Child; Humans; Ibuprofen; Morphine; Pain; Pain Management | 2018 |
AGEP from a dog bite treated with Ibuprofen.
Topics: Acute Generalized Exanthematous Pustulosis; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents | 2018 |
There may be a small reduction in pain immediately after tooth bleaching when consuming codeine plus acetaminophen, but this is unlikely to be important to patients or worth the potential risks.
Topics: Acetaminophen; Codeine; Double-Blind Method; Drug Combinations; Humans; Ibuprofen; Pain; Tooth Bleac | 2019 |
Pain Management during Rehabilitation after Distal Radius Fracture Stabilized with Volar Locking Plate: A Prospective Cohort Study.
Topics: Bone Plates; Buprenorphine; Codeine; Female; Fracture Fixation, Internal; Hand Strength; Humans; Ibu | 2018 |
Similar pain, swelling, and trismus after third-molar surgical extraction when receiving a phytotherapeutic drug, ibuprofen, or a placebo.
Topics: Edema; Humans; Ibuprofen; Molar; Molar, Third; Pain; Plant Extracts; Tooth Extraction; Tooth, Impact | 2019 |
Intra-articular mucilages: behavioural and histological evaluations for a new model of articular pain.
Topics: Althaea; Analgesics; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Flax; Freund's Adjuvan | 2019 |
Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs.
Topics: Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Healthy Voluntee | 2019 |
The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cell Line; Dinoprostone; Epit | 2019 |
Dr. Stewart Sanders Adams (16 April 1923 to 30 January 2019) : Pioneer in the discovery of ibuprofen, that from meagre beginnings to become world's best-selling pain-killing drug.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Discovery; History, 20th Century; History, 21st Centur | 2019 |
Effectiveness of neuromuscular electrical stimulation and ibuprofen for pain caused by necrosis of the femoral head: A retrospective study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; China; Electric Stimulation Therapy; Female; Femur Head Nec | 2019 |
Early and late anti nociceptive effects of sucrose on neonatal inflammatory pain in rats: Comparison to a non-steroidal anti-inflammatory drug.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Brain-Derived Neurotrophic Facto | 2019 |
NSAID choice: lessons from PRECISION.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Celecoxib; Humans; Ibuprofen; Napr | 2019 |
In search of safe pain relief: The analgesic and anti-inflammatory activity of phytosteryl ibuprofenates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ibuprofen; Mice; Pain | 2019 |
Response to Schiavenato, von Baeyer, and Craig's letter to the editor.
Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce | 2013 |
Handling Ibuprofen increases pain tolerance and decreases perceived pain intensity in a cold pressor test.
Topics: Adaptation, Psychological; Adolescent; Analgesics, Non-Narcotic; Cold Temperature; Female; Humans; I | 2013 |
Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Constipation; Endorphins; Ibuprofen; Locomotion; Male; | 2013 |
Preceding pain symptoms and Parkinson's disease: a nationwide population-based cohort study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Data Collection; Female; Human | 2013 |
Burrowing as a non-reflex behavioural readout for analgesic action in a rat model of sub-chronic knee joint inflammation.
Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Chronic D | 2014 |
More pain for painkillers.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Celecoxib; Cyclooxygenase | 2013 |
Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Ceftriaxone; Ce | 2014 |
Early intravenous ibuprofen decreases narcotic requirement and length of stay after traumatic rib fracture.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Drug Administration Schedule; Female; Humans; Ibuprofen; Infu | 2013 |
Early intravenous ibuprofen decreases narcotic requirement and length of stay after traumatic rib fracture.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Drug Administration Schedule; Female; Humans; Ibuprofen; Infu | 2013 |
Early intravenous ibuprofen decreases narcotic requirement and length of stay after traumatic rib fracture.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Drug Administration Schedule; Female; Humans; Ibuprofen; Infu | 2013 |
Early intravenous ibuprofen decreases narcotic requirement and length of stay after traumatic rib fracture.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Drug Administration Schedule; Female; Humans; Ibuprofen; Infu | 2013 |
Is fever treated more promptly than pain in the pediatric emergency department?
Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Antipyretics; Child; Child, Presch | 2014 |
[Pain management in dentistry].
Topics: Adolescent; Adult; Anesthesia, Local; Dentistry; Female; Humans; Ibuprofen; Male; Middle Aged; Pain; | 2013 |
Association between an excess risk of acute kidney injury and concomitant use of ibuprofen and acetaminophen in children, retrospective analysis of a spontaneous reporting system.
Topics: Acetaminophen; Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcoti | 2014 |
Evaluation of anti-inflammatory and analgesic effects of synthesized derivatives of ibuprofen.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyclooxygenase 1; Cy | 2015 |
S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, A | 2014 |
Peripheral synergism between tramadol and ibuprofen in the formalin test.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Formaldehy | 2014 |
Pain during Fallopian-tube patency testing by hysterosalpingo-foam sonography.
Topics: Adult; Analgesics, Non-Narcotic; Cross-Sectional Studies; Fallopian Tube Patency Tests; Fallopian Tu | 2015 |
Rescheduling of hydrocodone combination products.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Controlled Subs | 2014 |
Synthesis and in vitro Evaluation of Polymeric Prodrug of Ibuprofen with Amino Acid Spacer.
Topics: Alginates; Analgesics; Drug Liberation; Gastric Acid; Gastrointestinal Absorption; Glucuronic Acid; | 2015 |
Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats.
Topics: Adjuvants, Immunologic; Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxy | 2015 |
Levetiracetam synergises with common analgesics in producing antinociception in a mouse model of painful diabetic neuropathy.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Diabetic Neuropathies; Dose-Response Relationship, Drug | 2015 |
Optimal pain relief for pediatric MSK injury.
Topics: Acetaminophen; Analgesics; Canada; Child; Codeine; Drug Combinations; Humans; Ibuprofen; Morphine; M | 2015 |
Formulation of Novel Layered Sodium Carboxymethylcellulose Film Wound Dressings with Ibuprofen for Alleviating Wound Pain.
Topics: Bandages; Carboxymethylcellulose Sodium; Humans; Ibuprofen; Pain; Wound Healing | 2015 |
Factors Associated With Discharge After Initial Emergency Treatment of Pediatric Migraine.
Topics: Administration, Intranasal; Administration, Intravenous; Administration, Oral; Adolescent; Analgesic | 2017 |
Prevalence, trends, patterns and associations of analgesic use in Germany.
Topics: Acetaminophen; Adolescent; Adult; Age Factors; Aged; Analgesics; Aspirin; Diclofenac; Drug Therapy; | 2015 |
Cost-effectiveness of nonsteroidal anti-inflammatory drugs and opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Com | 2016 |
Ibuprofen intake increases exercise time to exhaustion: A possible role for preventing exercise-induced fatigue.
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Cortex; Fatigue; Ib | 2016 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D | 2016 |
Common pain relievers may increase heart problems. High-dosage ibuprofen and diclofenac linked to elevated risk of death; naproxen, acetaminophen offer alternatives.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Ibuprofen; Naproxen; Pai | 2010 |
Nurofen advertisement was misleading, says watchdog.
Topics: Advertising; Deception; Humans; Ibuprofen; Organ Specificity; Pain; Product Packaging; United Kingdo | 2016 |
Inoculation of Lewis lung carcinoma cells enhances formalin-induced pain behavior and spinal Fos expression in mice.
Topics: Analgesics, Non-Narcotic; Animals; Cancer Pain; Carcinoma, Lewis Lung; Formaldehyde; Ibuprofen; Male | 2017 |
Bridging the Gap Between In Vitro Dissolution and the Time Course of Ibuprofen-Mediating Pain Relief.
Topics: Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ste | 2016 |
Parental Approach to the Prevention and Management of Fever and Pain Following Childhood Immunizations: A Survey Study.
Topics: Acetaminophen; Adult; Analgesics; Antipyretics; Caregivers; Cross-Sectional Studies; Culture; Female | 2017 |
Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Opioid; Aspirin; Female; Humans; Ibuprofen; Internet; | 2017 |
Teething.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Humans; Ibuprofen; Infant; Materia Medica; Pain | 2016 |
Synthesis and Study of Analgesic and Anti-inflammatory Activities of Amide Derivatives of Ibuprofen.
Topics: Amides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Dr | 2017 |
pH-sensitive niosomes: Effects on cytotoxicity and on inflammation and pain in murine models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; BALB 3T3 Cells; Cells, Cultured; Disease Models, A | 2017 |
In vivo microvascular response of murine cutaneous muscle to ibuprofen-releasing polyurethane foam.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bandages; Cyclooxygenase Inhibitors; Disease Model | 2008 |
Antinociceptive activity of Buddleja globosa (matico) in several models of pain.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics; Animals; Buddleja; Chile; Disease Model | 2008 |
Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2.
Topics: Aminopyridines; Animals; Body Temperature; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; | 2008 |
How to make screening mammography less uncomfortable.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen | 2008 |
Arthritis as the presenting feature of HIV infection in a child.
Topics: Ankle Joint; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Child, | 2009 |
Commercially viable resolution of ibuprofen.
Topics: Alcohols; Anti-Inflammatory Agents, Non-Steroidal; Candida; Catalysis; Chemistry, Pharmaceutical; Cy | 2009 |
Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Controlled Clinic | 2009 |
Comment from the editor on Lambertz et al in the September 2008 issue.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Lidocaine; Mammogra | 2009 |
A fixed dose combination of ibuprofen and famotidine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Clinical Trials, Phase III as Topic; Dru | 2009 |
Synergistic interaction between rilmenidine and ibuprofen in the writhing test in mice.
Topics: Acetic Acid; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Dos | 2009 |
Guaifenesin enhances the analgesic potency of ibuprofen, nimesulide and celecoxib in mice.
Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cele | 2009 |
Going the distance. New pain treatment provide longer stronger relief.
Topics: Administration, Cutaneous; Analgesics; Carbazoles; Delayed-Action Preparations; Drug Combinations; D | 2007 |
Posttraumatic psoriatic osteitis of the frontal bone successfully treated with etanercept. Report of a case.
Topics: Acetaminophen; Anti-Inflammatory Agents; Child; Craniocerebral Trauma; Drug Therapy, Combination; Et | 2010 |
Housing environment influences the need for pain relief during post-operative recovery in mice.
Topics: Analgesics, Non-Narcotic; Anesthetics, Inhalation; Animals; Behavior, Animal; Body Weight; Disease M | 2010 |
Intravenous ibuprofen (Caldolor).
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Fever; Humans; | 2010 |
Caldolor: old drug, new route.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Fever; Humans; Ibuprofen; Injecti | 2010 |
Understanding idiosyncratic drug-induced neutropenia.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Leukocyte Count; Neutropen | 2010 |
Fracture pain relief for kids? Ibuprofen does it better.
Topics: Analgesics, Non-Narcotic; Arm Injuries; Child; Fracture Healing; Fractures, Bone; Humans; Ibuprofen; | 2010 |
Topical application of compound Ibuprofen suppresses pain by inhibiting sensory neuron hyperexcitability and neuroinflammation in a rat model of intervertebral foramen inflammation.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Disease Models, An | 2011 |
Dissociation of rewarding, anti-aversive and anti-nociceptive effects of different classes of anti-nociceptives in the rat.
Topics: Analgesics; Animals; Carrageenan; Conditioning, Psychological; Dose-Response Relationship, Drug; gam | 2011 |
A primer on pain relief.
Topics: Acetaminophen; Analgesia; Analgesics; Aspirin; Humans; Ibuprofen; Naproxen; Nonprescription Drugs; P | 2010 |
Pediatric nurses' beliefs and pain management practices: an intervention pilot.
Topics: Analgesics; Feasibility Studies; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Pilo | 2011 |
Demographic, medical, and behavioral characteristics associated with over the counter non-steroidal anti-inflammatory drug use in a population-based cohort: results from the Multi-Ethnic Study of Atherosclerosis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; | 2011 |
Ibuprofen transdermal ethosomal gel: characterization and efficiency in animal models.
Topics: Administration, Cutaneous; Analgesics, Non-Narcotic; Animals; Antipyretics; Disease Models, Animal; | 2010 |
Bridging the gap between pain assessment and treatment: time for a new theoretical approach?
Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce | 2011 |
Codeine did not increase analgesic efficacy of coxibs in contrast to that of paracetamol or ibuprofen: isobolographic analysis in mice.
Topics: Acetaminophen; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Celecoxib; Codein | 2011 |
Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic recommendations.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Knee Joint; Male; Pain | 2011 |
Three cases of slipped capital femoral epiphysis in one family.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Bone Screws; Child; Family Health; Female; Gene | 2011 |
Analgesic efficacy of an ibuprofen-releasing foam dressing compared with local best practice for painful exuding wounds.
Topics: Administration, Topical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; M | 2011 |
In vitro and in vivo evaluation of ibuprofen-paeonol conjugate.
Topics: Acetic Acid; Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceuti | 2011 |
Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclohexanec | 2012 |
Do Ibuprofen or glucosamine in addition to resistance exercise training improve muscle strength in patients with knee osteoarthritis?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Glucosamine; Humans; Ibuprofen; Male; Muscle Streng | 2012 |
[Migraine triggered by laughing as a form of presentation of a Chiari type I malformation].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arnold-Chiari Malformation; Brain; Humans; Ibuprofen | 2013 |
Intravenous ibuprofen: in adults for pain and fever.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Fever; Human | 2012 |
Alternating acetaminophen and ibuprofen for pain in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres | 2012 |
Self-report is a primary source of information about pain, but it is not infallible: a comment on "response to Voepel-Lewis's letter to the editor, 'bridging the gap between pain assessment and treatment: time for a new theoretical approach?'".
Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce | 2013 |
Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu.
Topics: Acacia; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Catechin; Edema; Flavonoids; For | 2012 |
Basic pain relievers. It's wise to use caution.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induc | 2012 |
Association of pain score documentation and analgesic use in a pediatric emergency department.
Topics: Acetaminophen; Administration, Oral; Adolescent; Age Factors; Analgesics; Child; Child, Preschool; D | 2012 |
Non-prescription medicines for pain and fever--a comparison of recommendations and counseling from staff in pharmacy and general sales stores.
Topics: Acetaminophen; Analgesics; Antipyretics; Aspirin; Child; Commerce; Contraindications; Counseling; Fe | 2013 |
Augmentation of analgesic effect of ibuprofen by alprazolam in experimental model of pain.
Topics: Acetic Acid; Acute Disease; Administration, Oral; Alprazolam; Analgesics, Non-Narcotic; Animals; Dis | 2002 |
Bayesian random effects meta-analysis of trials with binary outcomes: methods for the absolute risk difference and relative risk scales.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bayes Theorem; Clinical Trials as Topic; Humans; Ibuprofen; | 2002 |
Re: combination analgesic efficacy.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combinatio | 2002 |
[Recognizing the "neck-tongue" syndrome].
Topics: Acetates; Amines; Analgesics; Analgesics, Non-Narcotic; Arthritis; Cervical Vertebrae; Cyclohexaneca | 2003 |
Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Eating; Edema; Estradiol; | 2003 |
Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties.
Topics: Acetic Acid; Administration, Oral; Amides; Analgesics, Non-Narcotic; Animals; Ibuprofen; Injections, | 2003 |
Quantitative assessment of markers of inflammation, arthritis and pain in rats with adjuvant arthritis following the treatment with ibuprofen cream and placebo.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental | 2003 |
Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, No | 2003 |
Painful, swollen lower legs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Edema; Erythema Nodosum; Fe | 2003 |
Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Glutamic Acid; Ibuprofen; Injections | 2003 |
Paracetamol + tramadol: new preparation. No advance.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Codein | 2003 |
Ibuprofen-induced acute generalized exanthematous pustulosis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Buttocks; Diagnosis, Differential; | 2004 |
Preventing chronic ectopic bone-related pain and disability after hip replacement surgery with perioperative ibuprofen. A multicenter, randomized, double-blind, placebo-controlled trial (HIPAID).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Australia; Chemotherapy, Ad | 2004 |
Readers' forum: orthodontic pain.
Topics: Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Humans; Ibupro | 2004 |
Weak opiate analgesics: modest practical merits.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2004 |
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal; | 2004 |
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Age | 2005 |
Acid-induced pain and its modulation in humans.
Topics: Acid Sensing Ion Channels; Administration, Cutaneous; Adult; Amiloride; Analgesics; Anti-Inflammator | 2004 |
[Aspirin, paracetamol, ibuprofen: analgesics in the family medicine cabinet].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Contraind | 2005 |
Glomerular tip lesion associated with nonsteroidal anti-inflammatory drug-induced nephrotic syndrome.
Topics: Accidents, Traffic; Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Barbi | 2005 |
Pharmaceutical prescribing for children. Part 2. Analgesia and prescribing for children in pain.
Topics: Acetaminophen; Adolescent; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammato | 2005 |
Patterns of use and public perception of over-the-counter pain relievers: focus on nonsteroidal antiinflammatory drugs.
Topics: Acetaminophen; Adult; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Data Colle | 2005 |
A combination of oxycodone and ibuprofen (Combunox) for pain.
Topics: Drug Combinations; Humans; Ibuprofen; Oxycodone; Pain; Randomized Controlled Trials as Topic | 2006 |
Passage from India.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drinking; Humans; Ibuprofen; Kidney Calculi; Pain; Water | 2006 |
Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain.
Topics: Acute Disease; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic A | 2006 |
Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents.
Topics: Acetic Acid; Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavio | 2007 |
Tramadol infusion for the pain management in sickle cell disease: a case report.
Topics: Abdominal Pain; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Ch | 2007 |
New pain management options: drugs.
Topics: Analgesics, Opioid; Cannabidiol; Cannabinoids; Carbazoles; Chronic Disease; Dronabinol; Drug Combina | 2007 |
Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Dose-Response Rela | 2007 |
Analgesic activity of Ugni molinae (murtilla) in mice models of acute pain.
Topics: Acute Disease; Analgesics; Animals; Flavonoids; Glycosides; Ibuprofen; Male; Mice; Myrtaceae; Pain; | 2007 |
Do we need to incorporate pharmacogenetics in randomized, controlled trials of frequently used medicines?
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 2007 |
[Ambulatory pain management for children in the family practice].
Topics: Acetaminophen; Acute Disease; Ambulatory Care; Analgesics; Analgesics, Opioid; Child; Chronic Diseas | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Routine immunization practices: use of topical anesthetics and oral analgesics.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Anest | 2007 |
Pain, analgesics, and the cardiovascular system.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cyclooxygenase 2 Inhibitors; Gastr | 2006 |
Etoricoxib: new drug. Avoid using cox-2 inhibitors for pain.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Clinical | 2007 |
Some reflections on ibuprofen.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; History, 21st Century; I | 2007 |
The effects of ibuprofen on muscle hypertrophy, strength, and soreness during resistance training.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Exercise; Female; Humans; Hypertrophy; Ibuprofen; Ma | 2008 |
Ibuprofen--past, present, and future.
Topics: Animals; Arthritis, Rheumatoid; Blood Vessel Prosthesis; Drug Tolerance; Humans; Ibuprofen; Kinetics | 1984 |
Peripherally acting analgesics.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Aspirin; Diflunisal; Fenoprofen; Humans; Ibupro | 1984 |
A double-blind comparison of a propionic acid derivative (ibuprofen) and a fenamate (mefenamic acid) in the treatment of dysmenorrhea.
Topics: Adult; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Mefenamic Acid; Pain | 1983 |
Tolmetin-induced aseptic meningitis.
Topics: Adult; Female; Fever; Humans; Ibuprofen; Knee; Lupus Erythematosus, Systemic; Meningitis; Meningitis | 1981 |
Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats.
Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Dinoprostone; Formaldehyde; Glutamic Acid | 1995 |
Antinociception without motor blockade after subarachnoid administration of S-(+)-ibuprofen in rats.
Topics: Analysis of Variance; Animals; Ibuprofen; Injections, Spinal; Isomerism; Male; Morphine; Motor Neuro | 1994 |
NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-St | 1994 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |
Oral morphine protocol for sickle cell crisis pain.
Topics: Administration, Oral; Adolescent; Adult; Analgesics, Opioid; Anemia, Sickle Cell; Clinical Protocols | 1996 |
Delirium caused by tacrine and ibuprofen interaction.
Topics: Aged; Alzheimer Disease; Delirium; Dose-Response Relationship, Drug; Drug Interactions; Female; Huma | 1996 |
The effect of acetaminophen, ibuprofen, and misoprostol on prostaglandin E2 synthesis and the degree and rate of orthodontic tooth movement.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anti-Inflammatory Agents, No | 1996 |
Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Beh | 1996 |
Ibuprofen in human milk.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Female; Humans | 1997 |
If you have no destination, any road will do.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Ketorolac; Mus | 1998 |
Spinal action of ketorolac, S(+)- and R(-)-ibuprofen on non-noxious activation of the catechol oxidation in the rat locus coeruleus: evidence for a central role of prostaglandins in the strychnine model of allodynia.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Catechols; Electrophys | 1999 |
Importance of identifying foreign drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug and Narcotic Control; Humans; Ibuprofen; Int | 1999 |
Parental guidance suggested. Pediatric fever and pain relief require expert input.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Education; Fever; Humans; Ibuprofe | 1999 |
Comparison of analgesic effects of khat (Catha edulis Forsk) extract, D-amphetamine and ibuprofen in mice.
Topics: Acetic Acid; Amphetamine; Analgesia; Analgesics; Animals; Catha; Central Nervous System Stimulants; | 2000 |
Spontaneous brachial plexus hemorrhage-case report.
Topics: Analgesics, Non-Narcotic; Angiography; Brachial Plexus; Brachial Plexus Neuropathies; Diagnosis, Dif | 2000 |
Recurrence of ibuprofen-induced aseptic meningitis in an otherwise healthy patient.
Topics: Aged; Aggression; Anti-Inflammatory Agents, Non-Steroidal; Cerebrospinal Fluid; Diagnosis, Different | 1999 |
Investigational COX-2 inhibitor relieves pain in dental model.
Topics: Adolescent; Adult; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Etoricoxib; Humans; | 2001 |
Codeine for child pain: new preparation. Helpful in some cases.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1999 |
[NSAID as pure substance instead of racemase. Rapid pain control].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Pain; Stereoisomerism; Structure-Activit | 2001 |
Treatment of non-malignant pain in the Dutch GP population: an analysis of treatment standards, prescription habits and basic attitudes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Family Practice; Humans; Ibuprofen; Isomerism; Netherlands; | 2001 |
Pain treatment with NSAIDs, primary focus on ibuprofen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Humans; Ibuprofen; Pa | 2001 |
Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (-)-isomer.
Topics: Acetylcholine; Animals; Cattle; Cyclooxygenase Inhibitors; Erythema; Guinea Pigs; Ibuprofen; In Vitr | 1976 |
Analgesic drugs in the management of pain.
Topics: Analgesics; Anti-Anxiety Agents; Aspirin; Carbamazepine; Codeine; Dextropropoxyphene; Humans; Hypnot | 1977 |
Edema associated with ibuprofen therapy.
Topics: Aged; Diuresis; Edema; Humans; Ibuprofen; Male; Pain; Phenylpropionates | 1977 |
Pharmacological agents used in implant dentistry.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Dental Implantation, Endosseous; | 1992 |
4-(1,2-Benzisothiazol-3-yl)alkanoic and phenylalkanoic acids: synthesis and anti-inflammatory, analgesic and antipyretic activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Escherichia coli; Ibuprofen; M | 1992 |
Pure enantiomers of 2-arylpropionic acids: tools in pain research and improved drugs in rheumatology.
Topics: Animals; Humans; Ibuprofen; Ketoprofen; Pain; Propionates; Research; Rheumatic Diseases; Stereoisome | 1992 |
Blood pressure reactivity and perception of pain during the forehead cold pressor test.
Topics: Adolescent; Adult; Blood Pressure; Cold Temperature; Double-Blind Method; Heart Rate; Humans; Ibupro | 1991 |
Blood pressure reactivity and perception of pain during the forehead cold pressor test.
Topics: Adolescent; Adult; Blood Pressure; Cold Temperature; Double-Blind Method; Heart Rate; Humans; Ibupro | 1991 |
Blood pressure reactivity and perception of pain during the forehead cold pressor test.
Topics: Adolescent; Adult; Blood Pressure; Cold Temperature; Double-Blind Method; Heart Rate; Humans; Ibupro | 1991 |
Blood pressure reactivity and perception of pain during the forehead cold pressor test.
Topics: Adolescent; Adult; Blood Pressure; Cold Temperature; Double-Blind Method; Heart Rate; Humans; Ibupro | 1991 |
[Pain therapy with non-prescription analgesics].
Topics: Analgesics; Drug Combinations; Humans; Ibuprofen; Nonprescription Drugs; Pain; Pain Measurement | 1991 |
Flurbiprofen-associated acute tubulointerstitial nephritis.
Topics: Adult; Biopsy; Flurbiprofen; Humans; Ibuprofen; Kidney; Male; Nephritis, Interstitial; Pain | 1991 |
[Ibuprofen in pain therapy. A reliable form of self-medication. Report of a conference. Bad Schönborn, Bruchsal, 12 May 1990].
Topics: Humans; Ibuprofen; Pain; Self Medication | 1990 |
Acquired Brown's syndrome in systemic lupus erythematosus: another ocular manifestation.
Topics: Adult; Diclofenac; Diplopia; Fever; Humans; Hydroxychloroquine; Ibuprofen; Lupus Erythematosus, Syst | 1990 |
Ibuprofen vs acetaminophen in children.
Topics: Acetaminophen; Child; Drug Overdose; Fever; Humans; Ibuprofen; Pain; Suspensions | 1989 |
[Metoxibutropate].
Topics: Adult; Aged; Animals; Dysmenorrhea; Female; Guaiacol; Humans; Ibuprofen; Mice; Pain; Papio; Pregnanc | 1989 |
A new writhing model of factor XII activator-induced pain for assessment of non-steroidal anti-inflammatory agents. I. Kaolin-induced writhing in mice.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Captopril; Drug Synergism; Glycine | 1989 |
Interleukin-2 initiates metabolic responses associated with critical illness in humans.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Enterotoxins; Epinephrine; Escherichia coli; Female; Hormo | 1988 |
Complications of uterine leiomyomas in pregnancy.
Topics: Adult; Cesarean Section; Female; Fetal Membranes, Premature Rupture; Humans; Ibuprofen; Labor Presen | 1989 |
Pain and its management.
Topics: Adolescent; Analgesics; Dysmenorrhea; Female; Herpes Zoster; Humans; Ibuprofen; Male; Middle Aged; N | 1986 |
[The analgesic and antipyretic effects of a non-steroidal antiinflammatory agent, EB-382, in experimental animals].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Ibuprofen; Indom | 1986 |
The influence of ultrasound, galvanic currents and shortwave diathermy on pain intensity in patients with osteoarthritis.
Topics: Aged; Diathermy; Electric Stimulation Therapy; Hip Joint; Humans; Ibuprofen; Knee Joint; Middle Aged | 1987 |
Diclofenac sodium in the treatment of rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Diclofenac; Double-Blind Method; Female; Humans; Ibuprofen; Male; Mi | 1985 |
Diclofenac in the treatment of painful joints and traumatic tendinitis (including strains and sprains): a brief review.
Topics: Diclofenac; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Joint Diseases; Ketoprofen; Naproxen; | 1985 |
Intra-uterine pressure and serum ibuprofen: observations after oral administration of 400 mg ibuprofen to a patient with primary dysmenorrhoea.
Topics: Administration, Oral; Adult; Dysmenorrhea; Female; Humans; Ibuprofen; Kinetics; Pain; Pressure; Time | 1985 |