humanin has been researched along with Thrombosis* in 1 studies
1 other study(ies) available for humanin and Thrombosis
Article | Year |
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Humanin analogue, HNG, inhibits platelet activation and thrombus formation by stabilizing platelet microtubules.
HNG, a highly potent mutant of the anti-Alzheimer peptide-humanin, has been shown to protect against ischaemia-reperfusion (I/R) injury. However, the underlying mechanism related to platelet activation remains unknown. We proposed that HNG has an effect on platelet function and thrombus formation. In this study, platelet aggregation, granule secretion, clot retraction, integrin activation and adhesion under flow conditions were evaluated. In mice receiving HNG or saline, cremaster arterial thrombus formation induced by laser injury, tail bleeding time and blood loss were recorded. Platelet microtubule depolymerization was evaluated using immunofluorescence staining. Results showed that HNG inhibited platelet aggregation, P-selectin expression, ATP release, and α Topics: Adenosine Triphosphate; Animals; Blood Coagulation; Blood Platelets; Histone Deacetylase 6; Humans; Intracellular Signaling Peptides and Proteins; Mice; Microtubules; P-Selectin; Platelet Activation; Platelet Aggregation; Signal Transduction; Thrombosis | 2020 |