haloperidol has been researched along with Coma in 17 studies
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of haloperidol as treatment for ICU delirium and related symptoms remains controversial despite two recent large controlled trials evaluating its efficacy and safety." | 9.69 | Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial. ( Boer, DP; Brouwers, AJBW; Devlin, JW; Gommers, DAMPJ; Hunfeld, NGM; Lens, JA; Osse, RJ; Ponssen, HH; Rietdijk, WJR; Schoonderbeek, JF; Simons, KS; Slooter, AJC; Smit, L; Trogrlic, Z; van den Boogaard, M; van der Jagt, M, 2023) |
| "To compare the efficacy and safety of scheduled low-dose haloperidol versus placebo for the prevention of delirium (Intensive Care Delirium Screening Checklist ≥ 4) administered to critically ill adults with subsyndromal delirium (Intensive Care Delirium Screening Checklist = 1-3)." | 9.22 | Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study. ( Al-Qadheeb, NS; Devlin, JW; Pacheco, MN; Roberts, RJ; Ruthazer, RR; Schumaker, G; Skrobik, Y, 2016) |
| "These results do not support the hypothesis that haloperidol modifies duration of delirium in critically ill patients." | 9.17 | Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. ( Alce, T; Ely, EW; Gates, S; Jackson, J; McAuley, DF; Page, VJ; Perkins, GD; Shintani, A; Zhao, XB, 2013) |
| "The role of haloperidol as treatment for ICU delirium and related symptoms remains controversial despite two recent large controlled trials evaluating its efficacy and safety." | 5.69 | Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial. ( Boer, DP; Brouwers, AJBW; Devlin, JW; Gommers, DAMPJ; Hunfeld, NGM; Lens, JA; Osse, RJ; Ponssen, HH; Rietdijk, WJR; Schoonderbeek, JF; Simons, KS; Slooter, AJC; Smit, L; Trogrlic, Z; van den Boogaard, M; van der Jagt, M, 2023) |
| "The AID-ICU trial aims to assess the benefits and harms of haloperidol for the treatment of delirium in acutely admitted, adult intensive care unit (ICU) patients." | 5.34 | The Agents Intervening against Delirium in the Intensive Care Unit Trial (AID-ICU trial): A detailed statistical analysis plan. ( Andersen-Ranberg, N; Bestle, MH; Caballero, J; Citerio, G; Dey, N; Ebdrup, BH; Estrup, S; Hästbacka, J; Jensen, TB; Lange, T; Mathiesen, O; Morgan, MPG; Mortensen, CB; Nielsen, LG; Oxenbøll-Collet, M; Pedersen, HBS; Perner, A; Poulsen, LM; Sofie Andreasen, A; Thee, C; Uslu, B; Weber, SO; Wetterslev, J, 2020) |
| "To compare the efficacy and safety of scheduled low-dose haloperidol versus placebo for the prevention of delirium (Intensive Care Delirium Screening Checklist ≥ 4) administered to critically ill adults with subsyndromal delirium (Intensive Care Delirium Screening Checklist = 1-3)." | 5.22 | Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study. ( Al-Qadheeb, NS; Devlin, JW; Pacheco, MN; Roberts, RJ; Ruthazer, RR; Schumaker, G; Skrobik, Y, 2016) |
| "These results do not support the hypothesis that haloperidol modifies duration of delirium in critically ill patients." | 5.17 | Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. ( Alce, T; Ely, EW; Gates, S; Jackson, J; McAuley, DF; Page, VJ; Perkins, GD; Shintani, A; Zhao, XB, 2013) |
| "The prognosis of CCI patients with coma or delirium has not yet been thoroughly studied, but preliminary studies suggest this population is at high risk for detrimental outcomes associated with acute brain dysfunction." | 2.48 | Brain dysfunction in patients with chronic critical illness. ( Girard, TD, 2012) |
| "Variables measured included length of coma, PTA, rehabilitation admission and discharge functional status, and CT scan results." | 1.27 | Agitation in closed head injury: haloperidol effects on rehabilitation outcome. ( Jellinek, HM; Rao, N; Woolston, DC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Smit, L | 1 |
| Slooter, AJC | 1 |
| Devlin, JW | 2 |
| Trogrlic, Z | 1 |
| Hunfeld, NGM | 1 |
| Osse, RJ | 1 |
| Ponssen, HH | 1 |
| Brouwers, AJBW | 1 |
| Schoonderbeek, JF | 1 |
| Simons, KS | 1 |
| van den Boogaard, M | 2 |
| Lens, JA | 1 |
| Boer, DP | 1 |
| Gommers, DAMPJ | 1 |
| Rietdijk, WJR | 1 |
| van der Jagt, M | 1 |
| Andersen-Ranberg, N | 1 |
| Poulsen, LM | 1 |
| Perner, A | 1 |
| Wetterslev, J | 1 |
| Mathiesen, O | 1 |
| Mortensen, CB | 1 |
| Estrup, S | 1 |
| Ebdrup, BH | 1 |
| Hästbacka, J | 1 |
| Citerio, G | 1 |
| Caballero, J | 1 |
| Morgan, MPG | 1 |
| Oxenbøll-Collet, M | 1 |
| Weber, SO | 1 |
| Sofie Andreasen, A | 1 |
| Bestle, MH | 1 |
| Pedersen, HBS | 1 |
| Nielsen, LG | 1 |
| Uslu, B | 1 |
| Jensen, TB | 1 |
| Thee, C | 1 |
| Dey, N | 1 |
| Lange, T | 1 |
| Skrobik, Y | 2 |
| Page, VJ | 2 |
| Ely, EW | 1 |
| Gates, S | 1 |
| Zhao, XB | 1 |
| Alce, T | 1 |
| Shintani, A | 1 |
| Jackson, J | 1 |
| Perkins, GD | 1 |
| McAuley, DF | 1 |
| Pickkers, P | 1 |
| Viana, MV | 1 |
| Moraes, RB | 1 |
| Tonietto, TA | 1 |
| Boniatti, MM | 1 |
| Al-Qadheeb, NS | 1 |
| Schumaker, G | 1 |
| Pacheco, MN | 1 |
| Roberts, RJ | 1 |
| Ruthazer, RR | 1 |
| Girard, TD | 1 |
| Charra, B | 1 |
| Nejmi, H | 1 |
| Hachimi, A | 1 |
| Benslama, A | 1 |
| Motaouakkil, S | 1 |
| Vila, N | 1 |
| Chamorro, A | 1 |
| Geller, B | 1 |
| Greydanus, DE | 1 |
| Quenstedt, M | 1 |
| Ramsay, R | 1 |
| Bernadt, M | 1 |
| Velamoor, VR | 1 |
| Bennett, DA | 1 |
| Rao, N | 1 |
| Jellinek, HM | 1 |
| Woolston, DC | 1 |
| Bazhin, EF | 1 |
| Rafalovich, EG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Structured Cognitive Therapy to Improve Neurocognitive Dysfunction in Older Intensive Care Unit Sepsis Survivors[NCT04081090] | 1 participants (Actual) | Interventional | 2019-01-15 | Terminated (stopped due to Delay due to COVID. Lost funding.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for haloperidol and Coma
| Article | Year |
|---|---|
Brain dysfunction in patients with chronic critical illness.
Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Chronic Disease; Coma; Comorbid | 2012 |
4 trials available for haloperidol and Coma
| Article | Year |
|---|---|
Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial.
Topics: Adult; Aged; Antipsychotic Agents; Coma; Critical Illness; Delirium; Female; Haloperidol; Humans; In | 2023 |
The Agents Intervening against Delirium in the Intensive Care Unit Trial (AID-ICU trial): A detailed statistical analysis plan.
Topics: Adult; Coma; Delirium; Haloperidol; Humans; Intensive Care Units; Respiration, Artificial | 2020 |
Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial.
Topics: Aged; Coma; Critical Care; Critical Illness; Delirium; Dopamine Antagonists; Double-Blind Method; Fe | 2013 |
Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study.
Topics: Administration, Intravenous; Adult; Aged; Antipsychotic Agents; Coma; Critical Illness; Delirium; Do | 2016 |
12 other studies available for haloperidol and Coma
| Article | Year |
|---|---|
Can critical-care delirium be treated pharmacologically?
Topics: Coma; Delirium; Dopamine Antagonists; Female; Haloperidol; Humans; Male | 2013 |
Hope for haloperidol in delirium.
Topics: Coma; Delirium; Dopamine Antagonists; Female; Haloperidol; Humans; Male | 2013 |
Prophylactic haloperidol: too early to lose hope.
Topics: Coma; Delirium; Dopamine Antagonists; Female; Haloperidol; Humans; Male | 2013 |
Prophylactic haloperidol: too early to lose hope - author's reply.
Topics: Coma; Delirium; Dopamine Antagonists; Female; Haloperidol; Humans; Male | 2013 |
[Neuroleptic malignant syndrome].
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Coma; Combined Modality Therapy; Cryotherapy; Drug The | 2006 |
Ballistic movements due to ischemic infarcts after intravenous heroin overdose: report of two cases.
Topics: Adult; Anti-Dyskinesia Agents; Basal Ganglia; Brain Ischemia; Coma; Corpus Striatum; Drug Overdose; | 1997 |
Haloperidol-induced comatose state with hyperthermia and rigidity in adolescence: two case reports with a literature review.
Topics: Adolescent; Child; Child Behavior Disorders; Coma; Female; Fever; Haloperidol; Humans; Male; Muscle | 1979 |
Rapid tranquillisation.
Topics: Adult; Arousal; Chlorpromazine; Coma; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Comb | 1992 |
NMS complicated by diazepam.
Topics: Aged; Coma; Diazepam; Haloperidol; Humans; Male; Neuroleptic Malignant Syndrome; Risk Factors; Schiz | 1992 |
Combined neuroleptic malignant syndrome and the central anticholinergic syndrome.
Topics: Adult; Benztropine; Bipolar Disorder; Coma; Diagnosis, Differential; Drug Therapy, Combination; Halo | 1990 |
Agitation in closed head injury: haloperidol effects on rehabilitation outcome.
Topics: Amnesia; Brain; Brain Injuries; Coma; Haloperidol; Humans; Prognosis; Psychomotor Agitation; Retrosp | 1985 |
[Treatment of hallucinatory disorders in schizophrenia with atropine comas].
Topics: Amitriptyline; Atropine; Chlorpromazine; Coma; Drug Therapy, Combination; Epinephrine; Hallucination | 1973 |