gossypol and Glioma
gossypol has been researched along with Glioma in 6 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study evaluates the effects of AT101, alone or in combination with temozolomide (TMZ), in a microenvironmental glioma stem cell niche model of two GBM cell lines (U251MG and U87MG)." | 4.02 | Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche. ( Caylioglu, D; Held-Feindt, J; Hellmold, D; Kubelt, C; Meyer, RJ; Synowitz, M, 2021) |
| " AT 101 ([-]-gossypol), a natural compound from cotton seeds, induces ACD in glioma cells as confirmed here by CRISPR/Cas9 knockout of ATG5 that partially, but significantly rescued cell survival following AT 101 treatment." | 3.88 | AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. ( Behrends, C; Fulda, S; Kögel, D; Linder, B; Meyer, N; Michaelis, JB; Mittelbronn, M; Münch, C; Osiewacz, HD; Rakel, S; Warnsmann, V; Zielke, S, 2018) |
| "Gossypol is a lipid soluble polyphenolic compound isolated from cotton seed oil which has been previously shown to have antiproliferative activity in vitro against a variety of human solid tumor cell lines." | 1.29 | In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines. ( Coyle, T; Levante, S; Shetler, M; Winfield, J, 1994) |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Caylioglu, D | 1 |
| Meyer, RJ | 1 |
| Hellmold, D | 1 |
| Kubelt, C | 1 |
| Synowitz, M | 1 |
| Held-Feindt, J | 1 |
| Meyer, N | 1 |
| Zielke, S | 1 |
| Michaelis, JB | 1 |
| Linder, B | 2 |
| Warnsmann, V | 1 |
| Rakel, S | 1 |
| Osiewacz, HD | 1 |
| Fulda, S | 2 |
| Mittelbronn, M | 2 |
| Münch, C | 1 |
| Behrends, C | 1 |
| Kögel, D | 3 |
| Antonietti, P | 1 |
| Hehlgans, S | 1 |
| Mildenberger, IC | 1 |
| Burger, MC | 1 |
| Steinbach, JP | 2 |
| Gessler, F | 1 |
| Rödel, F | 1 |
| Voss, V | 1 |
| Senft, C | 1 |
| Lang, V | 1 |
| Ronellenfitsch, MW | 1 |
| Seifert, V | 1 |
| Coyle, T | 2 |
| Levante, S | 1 |
| Shetler, M | 1 |
| Winfield, J | 2 |
| Bushunow, P | 1 |
| Reidenberg, MM | 1 |
| Wasenko, J | 1 |
| Lorenzo, B | 1 |
| Lemke, S | 1 |
| Himpler, B | 1 |
| Corona, R | 1 |
Other Studies
6 other studies available for gossypol and Glioma
| Article | Year |
|---|---|
Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Carcinogenesis; Cell Line, T | 2021 |
AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells.
Topics: Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Glioma; Gossypol; Heme Oxygenase-1; Humans | 2018 |
Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Prote | 2017 |
The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma.
Topics: Animals; Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Dacarbazine; DNA Modification Methylases; | 2010 |
In vitro and in vivo cytotoxicity of gossypol against central nervous system tumor cell lines.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Central Nervous System Neoplasms; Glioma; | 1994 |
Gossypol treatment of recurrent adult malignant gliomas.
Topics: Adult; Aged; Brain Neoplasms; Disease-Free Survival; Female; Glioma; Gossypol; Humans; Male; Middle | 1999 |