gossypol has been researched along with Fibroid in 13 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gossypol acetate (GA), as the product of racemic gossypol and acetic acid conjugated by hydrogen bond, is hydrolyzed into gossypol to exert its effect on treating uterine leiomyoma (UL), which has been listed in China." | 8.31 | Comparison of the efficacy of gossypol acetate enantiomers in rats with uterine leiomyoma. ( Chang, J; Xin, X; Yao, J; Yuan, J; Zhou, M, 2023) |
| "to investigate the effect of gossypol on the growth of cultured human uterine leiomyoma and myometrial cells, the level of Bcl-2 and the activity of Src and estrogen receptor (ERα)." | 7.76 | Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells. ( CAO, L; CAO, Y; XIE, SW; ZHANG, JF; ZHANG, TT; ZHOU, JY; ZHU, Y, 2010) |
| "Gossypol acetate (GA), as the product of racemic gossypol and acetic acid conjugated by hydrogen bond, is hydrolyzed into gossypol to exert its effect on treating uterine leiomyoma (UL), which has been listed in China." | 4.31 | Comparison of the efficacy of gossypol acetate enantiomers in rats with uterine leiomyoma. ( Chang, J; Xin, X; Yao, J; Yuan, J; Zhou, M, 2023) |
| "to investigate the effect of gossypol on the growth of cultured human uterine leiomyoma and myometrial cells, the level of Bcl-2 and the activity of Src and estrogen receptor (ERα)." | 3.76 | Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells. ( CAO, L; CAO, Y; XIE, SW; ZHANG, JF; ZHANG, TT; ZHOU, JY; ZHU, Y, 2010) |
| "Gossypol treatment of endometriosis and uterine myomas in 15 cases was started with a daily dose of 20 mg of gossypol-acetic acid twice a day for 20 days as a loading dose, followed by 40 mg (20 mg twice weekly)." | 3.67 | Electron microscopic observations of the effects of gossypol on the human endometrium. ( Cheng, J; Dang, MY; Han, ML; Sun, YT; Tian, L; Zu, PD, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (84.62) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Yuan, J | 1 |
| Zhou, M | 1 |
| Xin, X | 1 |
| Yao, J | 1 |
| Chang, J | 1 |
| ZHU, Y | 1 |
| XIE, SW | 1 |
| ZHANG, JF | 1 |
| ZHANG, TT | 1 |
| ZHOU, JY | 1 |
| CAO, Y | 1 |
| CAO, L | 1 |
| Han, ML | 6 |
| Wang, YF | 6 |
| Ma, XH | 2 |
| Han, HL | 1 |
| Zu, PD | 1 |
| Sun, YT | 2 |
| Cheng, J | 1 |
| Tian, L | 1 |
| Dang, MY | 1 |
| Cheng, KF | 1 |
| Wu, WY | 1 |
| Tang, MY | 3 |
| Chu, PT | 1 |
| Zhu, YN | 1 |
| Ge, QS | 2 |
| Zhou, LF | 1 |
| Zhu, PD | 1 |
| Ye, XQ | 1 |
| Zhao, Y | 1 |
| Zhang, JC | 1 |
| Ye, LZ | 1 |
| Ma, SW | 1 |
| Luo, HY | 1 |
13 other studies available for gossypol and Fibroid
| Article | Year |
|---|---|
Comparison of the efficacy of gossypol acetate enantiomers in rats with uterine leiomyoma.
Topics: Animals; China; Gossypol; Leiomyoma; Rats; Stereoisomerism | 2023 |
Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells.
Topics: Adult; Apoptosis; Caspase 3; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Es | 2010 |
[Clinical observation of the gossypol treatment of endometriosis and uterine myoma and the location of the pharmacological action].
Topics: Adult; Endometriosis; Endometrium; Female; Gonadotropins, Pituitary; Gossypol; Humans; Leiomyoma; Mi | 1982 |
[A comparative study on rapid and slow loading of gossypol in the treatment of gynecological diseases].
Topics: Adult; Endometriosis; Female; Gossypol; Humans; Leiomyoma; Middle Aged; Ovary; Uterine Neoplasms | 1984 |
[Gossypol treatment for menopausal functional bleeding, myoma of uterus and endometriosis--preliminary report (author's transl)].
Topics: Adult; Endometriosis; Female; Gossypol; Humans; Leiomyoma; Menopause; Middle Aged; Uterine Hemorrhag | 1980 |
Electron microscopic observations of the effects of gossypol on the human endometrium.
Topics: Endocrine Glands; Endometriosis; Endometrium; Female; Gossypol; Humans; Leiomyoma; Menstruation; Tim | 1984 |
Endometrial changes after administration of gossypol for menorrhagia.
Topics: Adult; Atrophy; Endometriosis; Endometrium; Female; Gossypol; Humans; Leiomyoma; Menorrhagia; Middle | 1980 |
[Ultrastructural changes in smooth muscle cells in leiomyoma and the myometrium of the human uterus after gossypol treatment].
Topics: Adult; Female; Gossypol; Humans; Leiomyoma; Middle Aged; Mitochondria, Muscle; Muscle, Smooth; Myome | 1987 |
[Observation on blood biochemical indices after gossypol treatment in gynecological cases].
Topics: Adult; Cholesterol; Endometriosis; Female; Gossypol; Humans; Leiomyoma; Lipoproteins, HDL; Middle Ag | 1988 |
Gossypol in the treatment of endometriosis and uterine myoma.
Topics: Adult; Endometriosis; Female; Follicle Stimulating Hormone; Follow-Up Studies; Gossypol; Humans; Lei | 1987 |
[Late effect of gossypol treatment in gynecological diseases--a clinical study of 72 cases].
Topics: Adult; Endometriosis; Female; Follow-Up Studies; Gossypol; Humans; Leiomyoma; Medicine, Chinese Trad | 1985 |
[Clinical and experimental study of gossypol in the treatment of dysfunctional menorrhagia, endometriosis and fibromyoma of the uterus].
Topics: Adult; Aged; Animals; Endometriosis; Female; Gossypol; Humans; Leiomyoma; Menorrhagia; Middle Aged; | 1988 |
Studies on frequencies of sister chromatid exchange in peripheral blood lymphocytes before and after gossypol treatment.
Topics: Adult; Endometriosis; Female; Gossypol; Humans; Leiomyoma; Lymphocytes; Middle Aged; Sister Chromati | 1986 |