Page last updated: 2024-10-18

glycine and Glioma

glycine has been researched along with Glioma in 48 studies

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"We measured glycine, 2-hydroxyglutarate (2HG), and other tumor-related metabolites in 35 glioma patients using an MRS sequence tailored for co-detection of glycine and 2HG in gadolinium-enhancing and non-enhancing tumor regions on 3T MRI."7.96Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. ( An, Z; Askari, P; Baxter, J; Choi, C; Daoud, EV; DeBerardinis, RJ; Dimitrov, I; Ganji, SK; Gao, A; Hatanpaa, KJ; Levy, M; Lewis, CM; Madden, CJ; Maher, EA; Malloy, CR; Mickey, BE; Pan, E; Patel, TR; Pinho, MC; Raisanen, JM; Sherry, AD; Thomas, BP; Tiwari, V; Zhang, S, 2020)
" As brain tumors are enriched in the neurotransmitter glycine, we studied the expression and function of glycine receptors (GlyRs) in glioma cells."7.80Intracellular glycine receptor function facilitates glioma formation in vivo. ( Benedetti, B; Dzaye, O; Fähling, M; Förstera, B; Glass, R; Junier, MP; Kettenmann, H; Markovic, DS; Meier, JC; Semtner, M; Synowitz, M; Wend, P; Winkelmann, A, 2014)
"Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells."7.67Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987)
"Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days."7.66Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980)
"Glycine has been shown to possess important functions as a bidirectional neurotransmitter."5.35The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells. ( Abdin, JM; Dohi, T; Kitayama, T; Morioka, N; Morita, K; Nakata, Y, 2008)
"In 66 patients with advanced gliomas, ivosidenib was well tolerated, with no dose-limiting toxicities reported."5.34Ivosidenib in Isocitrate Dehydrogenase 1 ( Bowden, C; Burris, H; Choe, S; Cloughesy, TF; Cote, GM; De La Fuente, MI; Ellingson, BM; Fan, B; Holdhoff, M; Huang, R; Janku, F; Jiang, L; Lu, M; Maher, E; Mellinghoff, IK; Pandya, SS; Steelman, L; Touat, M; Wen, PY; Yen, K; Young, RJ, 2020)
"Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters."5.32Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004)
"We measured glycine, 2-hydroxyglutarate (2HG), and other tumor-related metabolites in 35 glioma patients using an MRS sequence tailored for co-detection of glycine and 2HG in gadolinium-enhancing and non-enhancing tumor regions on 3T MRI."3.96Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. ( An, Z; Askari, P; Baxter, J; Choi, C; Daoud, EV; DeBerardinis, RJ; Dimitrov, I; Ganji, SK; Gao, A; Hatanpaa, KJ; Levy, M; Lewis, CM; Madden, CJ; Maher, EA; Malloy, CR; Mickey, BE; Pan, E; Patel, TR; Pinho, MC; Raisanen, JM; Sherry, AD; Thomas, BP; Tiwari, V; Zhang, S, 2020)
"5-Benzylglycinyl-amiloride (UCD38B) is the parent molecule of a class of anticancer small molecules that kill proliferative and nonproliferative high-grade glioma cells by programmed necrosis."3.81Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. ( Gorin, F; Grodzki, AC; Pasupuleti, N, 2015)
" As brain tumors are enriched in the neurotransmitter glycine, we studied the expression and function of glycine receptors (GlyRs) in glioma cells."3.80Intracellular glycine receptor function facilitates glioma formation in vivo. ( Benedetti, B; Dzaye, O; Fähling, M; Förstera, B; Glass, R; Junier, MP; Kettenmann, H; Markovic, DS; Meier, JC; Semtner, M; Synowitz, M; Wend, P; Winkelmann, A, 2014)
" The aim of this study was to evaluate the effect of methylglyoxal exposure, over short (1 and 3 h) and long term (24 h) periods, on glucose, glycine and lactate metabolism in C6 glioma cells, as well as investigate the glyoxalase system and AGEs formation."3.78Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells. ( Bobermin, LD; de Souza, DF; Fontoura, JB; Gonçalves, CA; Hansen, F; Hoefel, AL; Leite, MC; Perry, ML; Silveira, Sda L; Tramontina, AC, 2012)
"55 ppm in a long echo time (TE) recognized as glycine (Gly) in the WHO grade II gliomas and central neurocytomas by means of 1H MRS."3.76Measurement of glycine in a brain and brain tumors by means of 1H MRS. ( Bobek-Billewicz, B; Hebda, A; Majchrzak, K; Stasik-Pres, G; Trojanowska, A; Zmuda, E, 2010)
"The effects of arachidonic acid on glycine uptake, exchange and efflux in C6 glioma cells were investigated."3.68Arachidonic acid inhibits glycine transport in cultured glial cells. ( Alcantara, R; Aragon, C; Gimenez, C; Gomeza, J; Zafra, F, 1990)
"The transport of glycine in C6 glioma cells takes place mainly in a heterogeneous Na+-dependent manner which can be resolved into different components."3.67Characteristics and adaptive regulation of glycine transport in cultured glial cells. ( Giménez, C; Zafra, F, 1989)
"Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells."3.67Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987)
"Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days."3.66Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980)
"H3."1.56Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling. ( Bush, K; Carcaboso, AM; Cervantes, V; Chen, KY; Klein, RH; Knoepfler, PS; Lechpammer, M; Lewis, N; Naqvi, A, 2020)
"Therefore, H3G34R/V/D mutations promote genome instability and tumorigenesis by inhibiting MMR activity."1.48Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSα interaction. ( Fang, J; Gu, L; Huang, Y; Li, GM; Li, H; Mao, G; Rennert, G; Yang, S, 2018)
"Glycine has been shown to possess important functions as a bidirectional neurotransmitter."1.35The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells. ( Abdin, JM; Dohi, T; Kitayama, T; Morioka, N; Morita, K; Nakata, Y, 2008)
"Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters."1.32Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004)

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19909 (18.75)18.7374
1990's10 (20.83)18.2507
2000's6 (12.50)29.6817
2010's13 (27.08)24.3611
2020's10 (20.83)2.80

Authors

AuthorsStudies
Sweha, SR1
Chung, C1
Natarajan, SK1
Panwalkar, P1
Pun, M1
Ghali, A1
Bayliss, J1
Pratt, D1
Shankar, A1
Ravikumar, V1
Rao, A1
Cieslik, M1
Wilder-Romans, K1
Scott, AJ1
Wahl, DR1
Jessa, S1
Kleinman, CL1
Jabado, N1
Mackay, A1
Jones, C1
Martinez, D1
Santi, M1
Judkins, AR1
Yadav, VN1
Qin, T1
Phoenix, TN1
Koschmann, CJ1
Baker, SJ1
Chinnaiyan, AM1
Venneti, S1
Ellingson, BM2
Kim, GHJ1
Brown, M1
Lee, J1
Salamon, N1
Steelman, L2
Hassan, I1
Pandya, SS2
Chun, S1
Linetsky, M1
Yoo, B1
Wen, PY2
Mellinghoff, IK2
Goldin, J1
Cloughesy, TF2
Gerstner, ER1
Vuong, HG1
Le, HT1
Dunn, IF1
Tiwari, V1
Daoud, EV1
Hatanpaa, KJ1
Gao, A1
Zhang, S1
An, Z1
Ganji, SK1
Raisanen, JM1
Lewis, CM1
Askari, P1
Baxter, J1
Levy, M1
Dimitrov, I1
Thomas, BP1
Pinho, MC1
Madden, CJ1
Pan, E1
Patel, TR1
DeBerardinis, RJ1
Sherry, AD1
Mickey, BE1
Malloy, CR1
Maher, EA1
Choi, C1
Keunen, O1
Niclou, SP1
Touat, M1
Maher, E1
De La Fuente, MI1
Holdhoff, M1
Cote, GM1
Burris, H1
Janku, F1
Young, RJ1
Huang, R1
Jiang, L1
Choe, S1
Fan, B1
Yen, K1
Lu, M1
Bowden, C1
Chen, KY1
Bush, K1
Klein, RH1
Cervantes, V1
Lewis, N1
Naqvi, A1
Carcaboso, AM1
Lechpammer, M1
Knoepfler, PS1
Molloy, AR1
Najac, C1
Viswanath, P1
Lakhani, A1
Subramani, E1
Batsios, G1
Radoul, M1
Gillespie, AM1
Pieper, RO1
Ronen, SM1
Liu, R1
Zeng, LW1
Gong, R1
Yuan, F1
Shu, HB1
Li, S1
Leske, H1
Rushing, E1
Budka, H1
Niehusmann, P1
Pahnke, J1
Panagopoulos, I1
Fang, J1
Huang, Y1
Mao, G1
Yang, S1
Rennert, G1
Gu, L1
Li, H1
Li, GM1
Kato, Y1
Natsume, A1
Kaneko, MK1
Förstera, B1
Dzaye, O1
Winkelmann, A1
Semtner, M1
Benedetti, B1
Markovic, DS1
Synowitz, M1
Wend, P1
Fähling, M1
Junier, MP1
Glass, R1
Kettenmann, H1
Meier, JC1
Pasupuleti, N1
Grodzki, AC1
Gorin, F1
Thomas, AG1
Sattler, R1
Tendyke, K1
Loiacono, KA1
Hansen, H1
Sahni, V1
Hashizume, Y1
Rojas, C1
Slusher, BS1
Ghasemi, K1
Khanmohammadi, M1
Saligheh Rad, H1
Solomon, DA1
Wood, MD1
Tihan, T1
Bollen, AW1
Gupta, N1
Phillips, JJ1
Perry, A1
Morioka, N1
Abdin, JM1
Morita, K1
Kitayama, T1
Nakata, Y1
Dohi, T1
Kim, EM1
Park, EH1
Cheong, SJ1
Lee, CM1
Kim, DW1
Jeong, HJ1
Lim, ST1
Sohn, MH1
Kim, K1
Chung, J1
Bobek-Billewicz, B1
Hebda, A1
Stasik-Pres, G1
Majchrzak, K1
Zmuda, E1
Trojanowska, A1
Wang, YY1
Liu, SC1
Yang, Z1
Zhang, T1
Custódio, AC1
Almeida, LO1
Pinto, GR1
Santos, MJ1
Almeida, JR1
Clara, CA1
Rey, JA1
Casartelli, C1
Shah, T1
Jayasundar, R1
Singh, VP1
Sarkar, C1
Hansen, F1
de Souza, DF1
Silveira, Sda L1
Hoefel, AL1
Fontoura, JB1
Tramontina, AC1
Bobermin, LD1
Leite, MC1
Perry, ML1
Gonçalves, CA1
Pearlman, RJ1
Aubrey, KR1
Vandenberg, RJ1
Javitt, DC1
Duncan, L1
Balla, A1
Sershen, H1
Brennan, L1
Hewage, C1
Malthouse, JP1
McBean, GJ1
Tong, ZY1
Toshiaki, Y1
Wang, YJ1
Kohl, RL2
Quay, WB2
Perez-Polo, JR2
Hagberg, G1
Burlina, AP1
Mader, I1
Roser, W1
Radue, EW1
Seelig, J1
Kinoshita, Y1
Kajiwara, H1
Yokota, A1
Koga, Y1
Ohkuma, S1
Katsura, M1
Chen, DZ1
Chen, SH1
Kuriyama, K1
Dowd, LA1
Robinson, MB2
Egorova, A1
Hoshi, N1
Knijnik, R1
Shahidullah, M1
Hashii, M1
Noda, M1
Higashida, H1
Davis, KE1
Straff, DJ1
Weinstein, EA1
Bannerman, PG1
Correale, DM1
Rothstein, JD2
Ye, ZC2
Sontheimer, H2
Henn, FA1
Skaper, SD1
Seegmiller, JE1
Skalski, V1
Feindel, W1
Panasci, LC1
Zafra, F4
Alcantara, R1
Gomeza, J1
Aragon, C1
Gimenez, C4
Le Moyec, L1
Naruse, S1
Higuchi, T1
Hirakawa, K1
Watari, H1
de Certaines, JD1
Roques, BP1
Hannuniemi, R1
Pajari-Backas, M1
Oja, OS1
Oja, SS1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation[NCT02073994]Phase 1170 participants (Anticipated)Interventional2014-03-01Active, not recruiting
The Effects of Glycine Transport Inhibition on Brain Glycine Concentration[NCT00538070]68 participants (Actual)Interventional2007-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for glycine and Glioma

ArticleYear
The prognostic significance of further genotyping H3G34 diffuse hemispheric gliomas.
    Cancer, 2022, 05-15, Volume: 128, Issue:10

    Topics: Brain Neoplasms; Genotype; Glioma; Glycine; Humans; Prognosis

2022

Trials

2 trials available for glycine and Glioma

ArticleYear
Volumetric measurements are preferred in the evaluation of mutant IDH inhibition in non-enhancing diffuse gliomas: Evidence from a phase I trial of ivosidenib.
    Neuro-oncology, 2022, 05-04, Volume: 24, Issue:5

    Topics: Brain Neoplasms; Glioma; Glycine; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Pyri

2022
Ivosidenib in Isocitrate Dehydrogenase 1
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020, 10-10, Volume: 38, Issue:29

    Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibi

2020

Other Studies

45 other studies available for glycine and Glioma

ArticleYear
Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas.
    Science translational medicine, 2021, Oct-13, Volume: 13, Issue:615

    Topics: Animals; Brain Neoplasms; Epigenesis, Genetic; Glioma; Glycine; Histones; Humans; Mice

2021
Volumetric measurements in low-grade glioma: Are we there yet?
    Neuro-oncology, 2022, 05-04, Volume: 24, Issue:5

    Topics: Glioma; Glycine; Humans; Pyridines

2022
Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.
    Neuro-oncology, 2020, 07-07, Volume: 22, Issue:7

    Topics: Adult; Aged; Biomarkers; Brain Neoplasms; Contrast Media; Female; Gadolinium; Glioma; Glutarates; Gl

2020
Is there a prominent role for MR spectroscopy in the clinical management of brain tumors?
    Neuro-oncology, 2020, 07-07, Volume: 22, Issue:7

    Topics: Biomarkers; Brain Neoplasms; Glioma; Glycine; Humans; Magnetic Resonance Spectroscopy

2020
Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.
    Communications biology, 2020, 07-09, Volume: 3, Issue:1

    Topics: Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Proliferation; Child; Female; Gene Edit

2020
MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma.
    Theranostics, 2020, Volume: 10, Issue:19

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy

2020
mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.
    Nature communications, 2021, 07-09, Volume: 12, Issue:1

    Topics: Acetyl-CoA C-Acetyltransferase; Acetylation; Animals; Carcinogenesis; Cell Line, Tumor; Gene Express

2021
K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution.
    Acta neuropathologica, 2018, Volume: 136, Issue:1

    Topics: Brain Neoplasms; DNA Mutational Analysis; Glioma; Glycine; Histones; Humans; Lysine; Mutation

2018
Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSα interaction.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 09-18, Volume: 115, Issue:38

    Topics: Carcinogenesis; Cell Line, Tumor; Child; DNA Mismatch Repair; Genomic Instability; Glioma; Glycine;

2018
A novel monoclonal antibody GMab-m1 specifically recognizes IDH1-R132G mutation.
    Biochemical and biophysical research communications, 2013, Mar-22, Volume: 432, Issue:4

    Topics: Amino Acid Substitution; Animals; Antibodies, Monoclonal; Arginine; Cell Line; Cricetinae; Glioma; G

2013
Intracellular glycine receptor function facilitates glioma formation in vivo.
    Journal of cell science, 2014, 09-01, Volume: 127, Issue:Pt 17

    Topics: Animals; Cell Line; Cytoplasm; Disease Models, Animal; Gene Expression Regulation; Gene Knockdown Te

2014
Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death.
    Molecular pharmacology, 2015, Volume: 87, Issue:4

    Topics: Amiloride; Antineoplastic Agents; Apoptosis Inducing Factor; Brain Neoplasms; Cell Line, Tumor; Endo

2015
High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Amino Acid Transport System y+; Benzoates; Brain Neoplasms; Cell Line, Tumor; Cystine; Databases, Ch

2015
Accurate grading of brain gliomas by soft independent modeling of class analogy based on non-negative matrix factorization of proton magnetic resonance spectra.
    Magnetic resonance in chemistry : MRC, 2016, Volume: 54, Issue:2

    Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glycine; Humans; Neoplasm Gra

2016
Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations.
    Brain pathology (Zurich, Switzerland), 2016, Volume: 26, Issue:5

    Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; ErbB Receptors; Female; Gene Expr

2016
The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells.
    Neurochemistry international, 2008, Volume: 53, Issue:6-8

    Topics: Animals; Astrocytes; Calcium; Carcinogens; Cell Line, Tumor; Diterpenes; Down-Regulation; Enzyme Inh

2008
Characterization, biodistribution and small-animal SPECT of I-125-labeled c-Met binding peptide in mice bearing c-Met receptor tyrosine kinase-positive tumor xenografts.
    Nuclear medicine and biology, 2009, Volume: 36, Issue:4

    Topics: Amino Acid Sequence; Animals; Binding, Competitive; Biological Transport; Blotting, Western; Capryla

2009
Measurement of glycine in a brain and brain tumors by means of 1H MRS.
    Folia neuropathologica, 2010, Volume: 48, Issue:3

    Topics: Adult; Brain Chemistry; Brain Neoplasms; Female; Glioma; Glycine; Humans; Magnetic Resonance Imaging

2010
Impaired hippocampal synaptic plasticity in C6 glioma-bearing rats.
    Journal of neuro-oncology, 2011, Volume: 103, Issue:3

    Topics: Animals; Body Weight; Brain Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disea

2011
Analysis of the polymorphisms XRCC1Arg194Trp and XRCC1Arg399Gln in gliomas.
    Genetics and molecular research : GMR, 2011, Jun-14, Volume: 10, Issue:2

    Topics: Arginine; Brain Neoplasms; DNA Primers; DNA-Binding Proteins; Glioma; Glycine; Humans; Polymerase Ch

2011
In vivo MRS study of intraventricular tumors.
    Journal of magnetic resonance imaging : JMRI, 2011, Volume: 34, Issue:5

    Topics: Adolescent; Adult; Brain Neoplasms; Cerebral Ventricle Neoplasms; Diagnosis, Differential; Female; G

2011
Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells.
    Metabolic brain disease, 2012, Volume: 27, Issue:4

    Topics: Cell Line, Tumor; Coloring Agents; Energy Metabolism; Glioma; Glucose; Glycation End Products, Advan

2012
Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a.
    Journal of neurochemistry, 2003, Volume: 84, Issue:3

    Topics: Amino Acid Transport Systems, Neutral; Animals; Arachidonic Acid; Arachidonic Acids; Biological Tran

2003
Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action.
    Molecular psychiatry, 2005, Volume: 10, Issue:3

    Topics: Amino Acid Transport System A; Amino Acids; Animals; Antipsychotic Agents; beta-Alanine; Cell Line,

2005
Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study.
    Neurochemistry international, 2004, Volume: 45, Issue:8

    Topics: Alanine; Alanine Transaminase; Brain Neoplasms; Cell Line, Tumor; Dicarboxylic Acids; Enzyme Inhibit

2004
Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative in vivo study.
    Chinese medical journal, 2005, Aug-05, Volume: 118, Issue:15

    Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glioma; Glycine; Humans; Inositol; Magnetic

2005
Elevation of gamma-aminobutyric acid in cultured rat C6 glioma cells following methionine supplementation.
    Journal of neurochemistry, 1980, Volume: 34, Issue:6

    Topics: Amino Acids; Animals; Cell Line; gamma-Aminobutyric Acid; Glioma; Glycine; Methionine; Rats; Serine

1980
Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells.
    Journal of neuroscience research, 1980, Volume: 5, Issue:4

    Topics: Animals; Brain Neoplasms; Cell Line; Enzyme Activation; Glioma; Glycine; Glycine Hydroxymethyltransf

1980
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
    Magnetic resonance in medicine, 1995, Volume: 34, Issue:2

    Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan

1995
Proton magnetic resonance spectroscopy of astrocytic tumors: an in vitro study.
    Neurologia medico-chirurgica, 1993, Volume: 33, Issue:6

    Topics: Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fe

1993
Presence of N-methyl-D-aspartate (NMDA) receptors in neuroblastoma x glioma hybrid NG108-15 cells-analysis using [45Ca2+]influx and [3H]MK-801 binding as functional measures.
    Brain research. Molecular brain research, 1994, Volume: 22, Issue:1-4

    Topics: Calcium Radioisotopes; Cations, Divalent; Dizocilpine Maleate; Glioma; Glutamates; Glutamic Acid; Gl

1994
Rapid stimulation of EAAC1-mediated Na+-dependent L-glutamate transport activity in C6 glioma cells by phorbol ester.
    Journal of neurochemistry, 1996, Volume: 67, Issue:2

    Topics: Adenylyl Cyclases; Amiloride; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding

1996
Sulfhydryl modification inhibits K+ (M) current with kinetics close to acetylcholine in rodent NG108-15 cells.
    Neuroscience research, 1997, Volume: 27, Issue:1

    Topics: Acetylcholine; Animals; Cysteine; Glioma; Glutathione; Glutathione Disulfide; Glycine; Hybrid Cells;

1997
Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Apr-01, Volume: 18, Issue:7

    Topics: Amino Acid Transport System X-AG; Androstadienes; Animals; Biological Transport; Carcinogens; Carrie

1998
Glioma cells release excitotoxic concentrations of glutamate.
    Cancer research, 1999, Sep-01, Volume: 59, Issue:17

    Topics: Animals; Benzoates; Biological Transport; Cell Line; Coculture Techniques; Excitatory Amino Acid Ant

1999
Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999, Dec-15, Volume: 19, Issue:24

    Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette

1999
Neurotransmission and glial cells: a functional relationship?
    Journal of neuroscience research, 1976, Volume: 2, Issue:4

    Topics: Amino Acids; Animals; Biological Transport, Active; Brain; Calcium; gamma-Aminobutyric Acid; Glioma;

1976
Elevated intracellular glycine associated with hypoxanthine-guanine phosphoribosyltransferase deficiency in glioma cells.
    Journal of neurochemistry, 1977, Volume: 29, Issue:1

    Topics: Amino Acids; Animals; Cell Division; Cell Line; Chick Embryo; Dogs; Glioma; Glycine; Hypoxanthine Ph

1977
Transport of amino acid amide sarcosinamide and sarcosinamide chloroethylnitrosourea in human glioma SK-MG-1 cells.
    Cancer research, 1990, May-15, Volume: 50, Issue:10

    Topics: Biological Transport, Active; Carmustine; Glioma; Glycine; Humans; Hydrogen-Ion Concentration; In Vi

1990
Arachidonic acid inhibits glycine transport in cultured glial cells.
    The Biochemical journal, 1990, Oct-01, Volume: 271, Issue:1

    Topics: Arachidonic Acid; Arachidonic Acids; Biological Transport; Cell Membrane; Cell Membrane Permeability

1990
In vivo 31P MRS in new antineoplastic agents evaluation on experimental tumor models.
    Cancer biochemistry biophysics, 1988, Volume: 10, Issue:1

    Topics: Animals; Antineoplastic Agents; Carbazoles; Carcinoma 256, Walker; Energy Metabolism; Female; Glioma

1988
Characteristics and adaptive regulation of glycine transport in cultured glial cells.
    The Biochemical journal, 1989, Mar-01, Volume: 258, Issue:2

    Topics: Amino Acids; Animals; Biological Transport; Cycloheximide; Dactinomycin; Glioma; Glycine; Hydrogen-I

1989
Characterization of glycine uptake in plasma membrane vesicles isolated from cultured glioblastoma cells.
    Brain research, 1986, Nov-05, Volume: 397, Issue:1

    Topics: Biological Transport; Cell Line; Cell Membrane; Glioma; Glycine; Kinetics; Nigericin; Onium Compound

1986
Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells.
    Acta physiologica Scandinavica, 1987, Volume: 131, Issue:4

    Topics: Animals; Aspartic Acid; Cell Line, Transformed; Glioma; Glycine; Humans; Leucine; Lysine; Neuroblast

1987
Efflux and exchange of glycine by plasma membrane vesicles isolated from glioblastoma cells.
    Biochimica et biophysica acta, 1988, Dec-22, Volume: 946, Issue:2

    Topics: Azo Compounds; Biological Transport; Cell Membrane; Chlorides; Glioma; Glycine; In Vitro Techniques;

1988