glycine and Glioma
glycine has been researched along with Glioma in 48 studies
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "We measured glycine, 2-hydroxyglutarate (2HG), and other tumor-related metabolites in 35 glioma patients using an MRS sequence tailored for co-detection of glycine and 2HG in gadolinium-enhancing and non-enhancing tumor regions on 3T MRI." | 7.96 | Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. ( An, Z; Askari, P; Baxter, J; Choi, C; Daoud, EV; DeBerardinis, RJ; Dimitrov, I; Ganji, SK; Gao, A; Hatanpaa, KJ; Levy, M; Lewis, CM; Madden, CJ; Maher, EA; Malloy, CR; Mickey, BE; Pan, E; Patel, TR; Pinho, MC; Raisanen, JM; Sherry, AD; Thomas, BP; Tiwari, V; Zhang, S, 2020) |
| " As brain tumors are enriched in the neurotransmitter glycine, we studied the expression and function of glycine receptors (GlyRs) in glioma cells." | 7.80 | Intracellular glycine receptor function facilitates glioma formation in vivo. ( Benedetti, B; Dzaye, O; Fähling, M; Förstera, B; Glass, R; Junier, MP; Kettenmann, H; Markovic, DS; Meier, JC; Semtner, M; Synowitz, M; Wend, P; Winkelmann, A, 2014) |
| "Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells." | 7.67 | Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987) |
| "Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days." | 7.66 | Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980) |
| "Glycine has been shown to possess important functions as a bidirectional neurotransmitter." | 5.35 | The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells. ( Abdin, JM; Dohi, T; Kitayama, T; Morioka, N; Morita, K; Nakata, Y, 2008) |
| "In 66 patients with advanced gliomas, ivosidenib was well tolerated, with no dose-limiting toxicities reported." | 5.34 | Ivosidenib in Isocitrate Dehydrogenase 1 ( Bowden, C; Burris, H; Choe, S; Cloughesy, TF; Cote, GM; De La Fuente, MI; Ellingson, BM; Fan, B; Holdhoff, M; Huang, R; Janku, F; Jiang, L; Lu, M; Maher, E; Mellinghoff, IK; Pandya, SS; Steelman, L; Touat, M; Wen, PY; Yen, K; Young, RJ, 2020) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 5.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| "We measured glycine, 2-hydroxyglutarate (2HG), and other tumor-related metabolites in 35 glioma patients using an MRS sequence tailored for co-detection of glycine and 2HG in gadolinium-enhancing and non-enhancing tumor regions on 3T MRI." | 3.96 | Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness. ( An, Z; Askari, P; Baxter, J; Choi, C; Daoud, EV; DeBerardinis, RJ; Dimitrov, I; Ganji, SK; Gao, A; Hatanpaa, KJ; Levy, M; Lewis, CM; Madden, CJ; Maher, EA; Malloy, CR; Mickey, BE; Pan, E; Patel, TR; Pinho, MC; Raisanen, JM; Sherry, AD; Thomas, BP; Tiwari, V; Zhang, S, 2020) |
| "5-Benzylglycinyl-amiloride (UCD38B) is the parent molecule of a class of anticancer small molecules that kill proliferative and nonproliferative high-grade glioma cells by programmed necrosis." | 3.81 | Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. ( Gorin, F; Grodzki, AC; Pasupuleti, N, 2015) |
| " As brain tumors are enriched in the neurotransmitter glycine, we studied the expression and function of glycine receptors (GlyRs) in glioma cells." | 3.80 | Intracellular glycine receptor function facilitates glioma formation in vivo. ( Benedetti, B; Dzaye, O; Fähling, M; Förstera, B; Glass, R; Junier, MP; Kettenmann, H; Markovic, DS; Meier, JC; Semtner, M; Synowitz, M; Wend, P; Winkelmann, A, 2014) |
| " The aim of this study was to evaluate the effect of methylglyoxal exposure, over short (1 and 3 h) and long term (24 h) periods, on glucose, glycine and lactate metabolism in C6 glioma cells, as well as investigate the glyoxalase system and AGEs formation." | 3.78 | Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells. ( Bobermin, LD; de Souza, DF; Fontoura, JB; Gonçalves, CA; Hansen, F; Hoefel, AL; Leite, MC; Perry, ML; Silveira, Sda L; Tramontina, AC, 2012) |
| "55 ppm in a long echo time (TE) recognized as glycine (Gly) in the WHO grade II gliomas and central neurocytomas by means of 1H MRS." | 3.76 | Measurement of glycine in a brain and brain tumors by means of 1H MRS. ( Bobek-Billewicz, B; Hebda, A; Majchrzak, K; Stasik-Pres, G; Trojanowska, A; Zmuda, E, 2010) |
| "The effects of arachidonic acid on glycine uptake, exchange and efflux in C6 glioma cells were investigated." | 3.68 | Arachidonic acid inhibits glycine transport in cultured glial cells. ( Alcantara, R; Aragon, C; Gimenez, C; Gomeza, J; Zafra, F, 1990) |
| "The transport of glycine in C6 glioma cells takes place mainly in a heterogeneous Na+-dependent manner which can be resolved into different components." | 3.67 | Characteristics and adaptive regulation of glycine transport in cultured glial cells. ( Giménez, C; Zafra, F, 1989) |
| "Non-saturable penetration and the V and Km constants of saturable influx of leucine, lysine and glycine were always greater in cultured neuroblastoma (C1300) than in glioma (C6) cells." | 3.67 | Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells. ( Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M, 1987) |
| "Human neuroblastoma SK-N-SH-SY5Y (5Y) and rat glioma (C6) cells were cultured with supplemental methionine, glycine, or serine for three to six days." | 3.66 | Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells. ( Kohl, RL; Perez-Polo, JR; Quay, WB, 1980) |
| "H3." | 1.56 | Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling. ( Bush, K; Carcaboso, AM; Cervantes, V; Chen, KY; Klein, RH; Knoepfler, PS; Lechpammer, M; Lewis, N; Naqvi, A, 2020) |
| "Therefore, H3G34R/V/D mutations promote genome instability and tumorigenesis by inhibiting MMR activity." | 1.48 | Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSα interaction. ( Fang, J; Gu, L; Huang, Y; Li, GM; Li, H; Mao, G; Rennert, G; Yang, S, 2018) |
| "Glycine has been shown to possess important functions as a bidirectional neurotransmitter." | 1.35 | The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells. ( Abdin, JM; Dohi, T; Kitayama, T; Morioka, N; Morita, K; Nakata, Y, 2008) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 1.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
Research
Studies (48)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (18.75) | 18.7374 |
| 1990's | 10 (20.83) | 18.2507 |
| 2000's | 6 (12.50) | 29.6817 |
| 2010's | 13 (27.08) | 24.3611 |
| 2020's | 10 (20.83) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sweha, SR | 1 |
| Chung, C | 1 |
| Natarajan, SK | 1 |
| Panwalkar, P | 1 |
| Pun, M | 1 |
| Ghali, A | 1 |
| Bayliss, J | 1 |
| Pratt, D | 1 |
| Shankar, A | 1 |
| Ravikumar, V | 1 |
| Rao, A | 1 |
| Cieslik, M | 1 |
| Wilder-Romans, K | 1 |
| Scott, AJ | 1 |
| Wahl, DR | 1 |
| Jessa, S | 1 |
| Kleinman, CL | 1 |
| Jabado, N | 1 |
| Mackay, A | 1 |
| Jones, C | 1 |
| Martinez, D | 1 |
| Santi, M | 1 |
| Judkins, AR | 1 |
| Yadav, VN | 1 |
| Qin, T | 1 |
| Phoenix, TN | 1 |
| Koschmann, CJ | 1 |
| Baker, SJ | 1 |
| Chinnaiyan, AM | 1 |
| Venneti, S | 1 |
| Ellingson, BM | 2 |
| Kim, GHJ | 1 |
| Brown, M | 1 |
| Lee, J | 1 |
| Salamon, N | 1 |
| Steelman, L | 2 |
| Hassan, I | 1 |
| Pandya, SS | 2 |
| Chun, S | 1 |
| Linetsky, M | 1 |
| Yoo, B | 1 |
| Wen, PY | 2 |
| Mellinghoff, IK | 2 |
| Goldin, J | 1 |
| Cloughesy, TF | 2 |
| Gerstner, ER | 1 |
| Vuong, HG | 1 |
| Le, HT | 1 |
| Dunn, IF | 1 |
| Tiwari, V | 1 |
| Daoud, EV | 1 |
| Hatanpaa, KJ | 1 |
| Gao, A | 1 |
| Zhang, S | 1 |
| An, Z | 1 |
| Ganji, SK | 1 |
| Raisanen, JM | 1 |
| Lewis, CM | 1 |
| Askari, P | 1 |
| Baxter, J | 1 |
| Levy, M | 1 |
| Dimitrov, I | 1 |
| Thomas, BP | 1 |
| Pinho, MC | 1 |
| Madden, CJ | 1 |
| Pan, E | 1 |
| Patel, TR | 1 |
| DeBerardinis, RJ | 1 |
| Sherry, AD | 1 |
| Mickey, BE | 1 |
| Malloy, CR | 1 |
| Maher, EA | 1 |
| Choi, C | 1 |
| Keunen, O | 1 |
| Niclou, SP | 1 |
| Touat, M | 1 |
| Maher, E | 1 |
| De La Fuente, MI | 1 |
| Holdhoff, M | 1 |
| Cote, GM | 1 |
| Burris, H | 1 |
| Janku, F | 1 |
| Young, RJ | 1 |
| Huang, R | 1 |
| Jiang, L | 1 |
| Choe, S | 1 |
| Fan, B | 1 |
| Yen, K | 1 |
| Lu, M | 1 |
| Bowden, C | 1 |
| Chen, KY | 1 |
| Bush, K | 1 |
| Klein, RH | 1 |
| Cervantes, V | 1 |
| Lewis, N | 1 |
| Naqvi, A | 1 |
| Carcaboso, AM | 1 |
| Lechpammer, M | 1 |
| Knoepfler, PS | 1 |
| Molloy, AR | 1 |
| Najac, C | 1 |
| Viswanath, P | 1 |
| Lakhani, A | 1 |
| Subramani, E | 1 |
| Batsios, G | 1 |
| Radoul, M | 1 |
| Gillespie, AM | 1 |
| Pieper, RO | 1 |
| Ronen, SM | 1 |
| Liu, R | 1 |
| Zeng, LW | 1 |
| Gong, R | 1 |
| Yuan, F | 1 |
| Shu, HB | 1 |
| Li, S | 1 |
| Leske, H | 1 |
| Rushing, E | 1 |
| Budka, H | 1 |
| Niehusmann, P | 1 |
| Pahnke, J | 1 |
| Panagopoulos, I | 1 |
| Fang, J | 1 |
| Huang, Y | 1 |
| Mao, G | 1 |
| Yang, S | 1 |
| Rennert, G | 1 |
| Gu, L | 1 |
| Li, H | 1 |
| Li, GM | 1 |
| Kato, Y | 1 |
| Natsume, A | 1 |
| Kaneko, MK | 1 |
| Förstera, B | 1 |
| Dzaye, O | 1 |
| Winkelmann, A | 1 |
| Semtner, M | 1 |
| Benedetti, B | 1 |
| Markovic, DS | 1 |
| Synowitz, M | 1 |
| Wend, P | 1 |
| Fähling, M | 1 |
| Junier, MP | 1 |
| Glass, R | 1 |
| Kettenmann, H | 1 |
| Meier, JC | 1 |
| Pasupuleti, N | 1 |
| Grodzki, AC | 1 |
| Gorin, F | 1 |
| Thomas, AG | 1 |
| Sattler, R | 1 |
| Tendyke, K | 1 |
| Loiacono, KA | 1 |
| Hansen, H | 1 |
| Sahni, V | 1 |
| Hashizume, Y | 1 |
| Rojas, C | 1 |
| Slusher, BS | 1 |
| Ghasemi, K | 1 |
| Khanmohammadi, M | 1 |
| Saligheh Rad, H | 1 |
| Solomon, DA | 1 |
| Wood, MD | 1 |
| Tihan, T | 1 |
| Bollen, AW | 1 |
| Gupta, N | 1 |
| Phillips, JJ | 1 |
| Perry, A | 1 |
| Morioka, N | 1 |
| Abdin, JM | 1 |
| Morita, K | 1 |
| Kitayama, T | 1 |
| Nakata, Y | 1 |
| Dohi, T | 1 |
| Kim, EM | 1 |
| Park, EH | 1 |
| Cheong, SJ | 1 |
| Lee, CM | 1 |
| Kim, DW | 1 |
| Jeong, HJ | 1 |
| Lim, ST | 1 |
| Sohn, MH | 1 |
| Kim, K | 1 |
| Chung, J | 1 |
| Bobek-Billewicz, B | 1 |
| Hebda, A | 1 |
| Stasik-Pres, G | 1 |
| Majchrzak, K | 1 |
| Zmuda, E | 1 |
| Trojanowska, A | 1 |
| Wang, YY | 1 |
| Liu, SC | 1 |
| Yang, Z | 1 |
| Zhang, T | 1 |
| Custódio, AC | 1 |
| Almeida, LO | 1 |
| Pinto, GR | 1 |
| Santos, MJ | 1 |
| Almeida, JR | 1 |
| Clara, CA | 1 |
| Rey, JA | 1 |
| Casartelli, C | 1 |
| Shah, T | 1 |
| Jayasundar, R | 1 |
| Singh, VP | 1 |
| Sarkar, C | 1 |
| Hansen, F | 1 |
| de Souza, DF | 1 |
| Silveira, Sda L | 1 |
| Hoefel, AL | 1 |
| Fontoura, JB | 1 |
| Tramontina, AC | 1 |
| Bobermin, LD | 1 |
| Leite, MC | 1 |
| Perry, ML | 1 |
| Gonçalves, CA | 1 |
| Pearlman, RJ | 1 |
| Aubrey, KR | 1 |
| Vandenberg, RJ | 1 |
| Javitt, DC | 1 |
| Duncan, L | 1 |
| Balla, A | 1 |
| Sershen, H | 1 |
| Brennan, L | 1 |
| Hewage, C | 1 |
| Malthouse, JP | 1 |
| McBean, GJ | 1 |
| Tong, ZY | 1 |
| Toshiaki, Y | 1 |
| Wang, YJ | 1 |
| Kohl, RL | 2 |
| Quay, WB | 2 |
| Perez-Polo, JR | 2 |
| Hagberg, G | 1 |
| Burlina, AP | 1 |
| Mader, I | 1 |
| Roser, W | 1 |
| Radue, EW | 1 |
| Seelig, J | 1 |
| Kinoshita, Y | 1 |
| Kajiwara, H | 1 |
| Yokota, A | 1 |
| Koga, Y | 1 |
| Ohkuma, S | 1 |
| Katsura, M | 1 |
| Chen, DZ | 1 |
| Chen, SH | 1 |
| Kuriyama, K | 1 |
| Dowd, LA | 1 |
| Robinson, MB | 2 |
| Egorova, A | 1 |
| Hoshi, N | 1 |
| Knijnik, R | 1 |
| Shahidullah, M | 1 |
| Hashii, M | 1 |
| Noda, M | 1 |
| Higashida, H | 1 |
| Davis, KE | 1 |
| Straff, DJ | 1 |
| Weinstein, EA | 1 |
| Bannerman, PG | 1 |
| Correale, DM | 1 |
| Rothstein, JD | 2 |
| Ye, ZC | 2 |
| Sontheimer, H | 2 |
| Henn, FA | 1 |
| Skaper, SD | 1 |
| Seegmiller, JE | 1 |
| Skalski, V | 1 |
| Feindel, W | 1 |
| Panasci, LC | 1 |
| Zafra, F | 4 |
| Alcantara, R | 1 |
| Gomeza, J | 1 |
| Aragon, C | 1 |
| Gimenez, C | 4 |
| Le Moyec, L | 1 |
| Naruse, S | 1 |
| Higuchi, T | 1 |
| Hirakawa, K | 1 |
| Watari, H | 1 |
| de Certaines, JD | 1 |
| Roques, BP | 1 |
| Hannuniemi, R | 1 |
| Pajari-Backas, M | 1 |
| Oja, OS | 1 |
| Oja, SS | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation[NCT02073994] | Phase 1 | 170 participants (Anticipated) | Interventional | 2014-03-01 | Active, not recruiting | ||
| The Effects of Glycine Transport Inhibition on Brain Glycine Concentration[NCT00538070] | 68 participants (Actual) | Interventional | 2007-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for glycine and Glioma
| Article | Year |
|---|---|
The prognostic significance of further genotyping H3G34 diffuse hemispheric gliomas.
Topics: Brain Neoplasms; Genotype; Glioma; Glycine; Humans; Prognosis | 2022 |
Trials
2 trials available for glycine and Glioma
| Article | Year |
|---|---|
Volumetric measurements are preferred in the evaluation of mutant IDH inhibition in non-enhancing diffuse gliomas: Evidence from a phase I trial of ivosidenib.
Topics: Brain Neoplasms; Glioma; Glycine; Humans; Isocitrate Dehydrogenase; Magnetic Resonance Imaging; Pyri | 2022 |
Ivosidenib in Isocitrate Dehydrogenase 1
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibi | 2020 |
Other Studies
45 other studies available for glycine and Glioma
| Article | Year |
|---|---|
Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas.
Topics: Animals; Brain Neoplasms; Epigenesis, Genetic; Glioma; Glycine; Histones; Humans; Mice | 2021 |
Volumetric measurements in low-grade glioma: Are we there yet?
Topics: Glioma; Glycine; Humans; Pyridines | 2022 |
Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.
Topics: Adult; Aged; Biomarkers; Brain Neoplasms; Contrast Media; Female; Gadolinium; Glioma; Glutarates; Gl | 2020 |
Is there a prominent role for MR spectroscopy in the clinical management of brain tumors?
Topics: Biomarkers; Brain Neoplasms; Glioma; Glycine; Humans; Magnetic Resonance Spectroscopy | 2020 |
Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Proliferation; Child; Female; Gene Edit | 2020 |
MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy | 2020 |
mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.
Topics: Acetyl-CoA C-Acetyltransferase; Acetylation; Animals; Carcinogenesis; Cell Line, Tumor; Gene Express | 2021 |
K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution.
Topics: Brain Neoplasms; DNA Mutational Analysis; Glioma; Glycine; Histones; Humans; Lysine; Mutation | 2018 |
Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3-MutSα interaction.
Topics: Carcinogenesis; Cell Line, Tumor; Child; DNA Mismatch Repair; Genomic Instability; Glioma; Glycine; | 2018 |
A novel monoclonal antibody GMab-m1 specifically recognizes IDH1-R132G mutation.
Topics: Amino Acid Substitution; Animals; Antibodies, Monoclonal; Arginine; Cell Line; Cricetinae; Glioma; G | 2013 |
Intracellular glycine receptor function facilitates glioma formation in vivo.
Topics: Animals; Cell Line; Cytoplasm; Disease Models, Animal; Gene Expression Regulation; Gene Knockdown Te | 2014 |
Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death.
Topics: Amiloride; Antineoplastic Agents; Apoptosis Inducing Factor; Brain Neoplasms; Cell Line, Tumor; Endo | 2015 |
High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells.
Topics: Amino Acid Transport System y+; Benzoates; Brain Neoplasms; Cell Line, Tumor; Cystine; Databases, Ch | 2015 |
Accurate grading of brain gliomas by soft independent modeling of class analogy based on non-negative matrix factorization of proton magnetic resonance spectra.
Topics: Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glycine; Humans; Neoplasm Gra | 2016 |
Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Child, Preschool; ErbB Receptors; Female; Gene Expr | 2016 |
The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Calpha in C6 glioma cells.
Topics: Animals; Astrocytes; Calcium; Carcinogens; Cell Line, Tumor; Diterpenes; Down-Regulation; Enzyme Inh | 2008 |
Characterization, biodistribution and small-animal SPECT of I-125-labeled c-Met binding peptide in mice bearing c-Met receptor tyrosine kinase-positive tumor xenografts.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Biological Transport; Blotting, Western; Capryla | 2009 |
Measurement of glycine in a brain and brain tumors by means of 1H MRS.
Topics: Adult; Brain Chemistry; Brain Neoplasms; Female; Glioma; Glycine; Humans; Magnetic Resonance Imaging | 2010 |
Impaired hippocampal synaptic plasticity in C6 glioma-bearing rats.
Topics: Animals; Body Weight; Brain Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disea | 2011 |
Analysis of the polymorphisms XRCC1Arg194Trp and XRCC1Arg399Gln in gliomas.
Topics: Arginine; Brain Neoplasms; DNA Primers; DNA-Binding Proteins; Glioma; Glycine; Humans; Polymerase Ch | 2011 |
In vivo MRS study of intraventricular tumors.
Topics: Adolescent; Adult; Brain Neoplasms; Cerebral Ventricle Neoplasms; Diagnosis, Differential; Female; G | 2011 |
Methylglyoxal alters glucose metabolism and increases AGEs content in C6 glioma cells.
Topics: Cell Line, Tumor; Coloring Agents; Energy Metabolism; Glioma; Glucose; Glycation End Products, Advan | 2012 |
Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a.
Topics: Amino Acid Transport Systems, Neutral; Animals; Arachidonic Acid; Arachidonic Acids; Biological Tran | 2003 |
Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action.
Topics: Amino Acid Transport System A; Amino Acids; Animals; Antipsychotic Agents; beta-Alanine; Cell Line, | 2005 |
Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study.
Topics: Alanine; Alanine Transaminase; Brain Neoplasms; Cell Line, Tumor; Dicarboxylic Acids; Enzyme Inhibit | 2004 |
Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative in vivo study.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Glioma; Glycine; Humans; Inositol; Magnetic | 2005 |
Elevation of gamma-aminobutyric acid in cultured rat C6 glioma cells following methionine supplementation.
Topics: Amino Acids; Animals; Cell Line; gamma-Aminobutyric Acid; Glioma; Glycine; Methionine; Rats; Serine | 1980 |
Effect of methionine, glycine and serine on serine hydroxymethyltransferase activity in rat glioma and human neuroblastoma cells.
Topics: Animals; Brain Neoplasms; Cell Line; Enzyme Activation; Glioma; Glycine; Glycine Hydroxymethyltransf | 1980 |
In vivo proton MR spectroscopy of human gliomas: definition of metabolic coordinates for multi-dimensional classification.
Topics: Adult; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Cluster Analysis; Creatine; Discriminan | 1995 |
Proton magnetic resonance spectroscopy of astrocytic tumors: an in vitro study.
Topics: Antibodies, Monoclonal; Astrocytoma; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Fe | 1993 |
Presence of N-methyl-D-aspartate (NMDA) receptors in neuroblastoma x glioma hybrid NG108-15 cells-analysis using [45Ca2+]influx and [3H]MK-801 binding as functional measures.
Topics: Calcium Radioisotopes; Cations, Divalent; Dizocilpine Maleate; Glioma; Glutamates; Glutamic Acid; Gl | 1994 |
Rapid stimulation of EAAC1-mediated Na+-dependent L-glutamate transport activity in C6 glioma cells by phorbol ester.
Topics: Adenylyl Cyclases; Amiloride; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding | 1996 |
Sulfhydryl modification inhibits K+ (M) current with kinetics close to acetylcholine in rodent NG108-15 cells.
Topics: Acetylcholine; Animals; Cysteine; Glioma; Glutathione; Glutathione Disulfide; Glycine; Hybrid Cells; | 1997 |
Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma.
Topics: Amino Acid Transport System X-AG; Androstadienes; Animals; Biological Transport; Carcinogens; Carrie | 1998 |
Glioma cells release excitotoxic concentrations of glutamate.
Topics: Animals; Benzoates; Biological Transport; Cell Line; Coculture Techniques; Excitatory Amino Acid Ant | 1999 |
Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange.
Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette | 1999 |
Neurotransmission and glial cells: a functional relationship?
Topics: Amino Acids; Animals; Biological Transport, Active; Brain; Calcium; gamma-Aminobutyric Acid; Glioma; | 1976 |
Elevated intracellular glycine associated with hypoxanthine-guanine phosphoribosyltransferase deficiency in glioma cells.
Topics: Amino Acids; Animals; Cell Division; Cell Line; Chick Embryo; Dogs; Glioma; Glycine; Hypoxanthine Ph | 1977 |
Transport of amino acid amide sarcosinamide and sarcosinamide chloroethylnitrosourea in human glioma SK-MG-1 cells.
Topics: Biological Transport, Active; Carmustine; Glioma; Glycine; Humans; Hydrogen-Ion Concentration; In Vi | 1990 |
Arachidonic acid inhibits glycine transport in cultured glial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Biological Transport; Cell Membrane; Cell Membrane Permeability | 1990 |
In vivo 31P MRS in new antineoplastic agents evaluation on experimental tumor models.
Topics: Animals; Antineoplastic Agents; Carbazoles; Carcinoma 256, Walker; Energy Metabolism; Female; Glioma | 1988 |
Characteristics and adaptive regulation of glycine transport in cultured glial cells.
Topics: Amino Acids; Animals; Biological Transport; Cycloheximide; Dactinomycin; Glioma; Glycine; Hydrogen-I | 1989 |
Characterization of glycine uptake in plasma membrane vesicles isolated from cultured glioblastoma cells.
Topics: Biological Transport; Cell Line; Cell Membrane; Glioma; Glycine; Kinetics; Nigericin; Onium Compound | 1986 |
Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells.
Topics: Animals; Aspartic Acid; Cell Line, Transformed; Glioma; Glycine; Humans; Leucine; Lysine; Neuroblast | 1987 |
Efflux and exchange of glycine by plasma membrane vesicles isolated from glioblastoma cells.
Topics: Azo Compounds; Biological Transport; Cell Membrane; Chlorides; Glioma; Glycine; In Vitro Techniques; | 1988 |