glycine and Amnesia studies

Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)

Research Excerpts

Excerpt	Relevance	Reference
"We examined the effect of the acetylcholinesterase (AChE) inhibitor, donepezil hydrocloride (DONP), on group II metabotropic glutamate (mGlu) receptor agonist- or antagonist-induced amnesia in the step-through passive avoidance task in male mice."	7.72	Effect of donepezil on group II mGlu receptor agonist- or antagonist-induced amnesia on passive avoidance in mice. ( Irifune, M; Nishikawa, T; Ohnishi, Y; Sato, T; Tanaka, K, 2003)
"We investigated the interrelationship of delayed amnesia, delayed neuronal death and changes in acetylcholine concentration induced by carbon monoxide (CO)-exposure in mice."	7.68	Carbon monoxide-induced delayed amnesia, delayed neuronal death and change in acetylcholine concentration in mice. ( Fukuta, T; Inari, K; Ishimaru, H; Kameyama, T; Katoh, A; Murase, K; Nabeshima, T; Ogita, K; Ohtsuka, H; Yoneda, Y, 1991)
"We examined the effect of the acetylcholinesterase (AChE) inhibitor, donepezil hydrocloride (DONP), on group II metabotropic glutamate (mGlu) receptor agonist- or antagonist-induced amnesia in the step-through passive avoidance task in male mice."	3.72	Effect of donepezil on group II mGlu receptor agonist- or antagonist-induced amnesia on passive avoidance in mice. ( Irifune, M; Nishikawa, T; Ohnishi, Y; Sato, T; Tanaka, K, 2003)
" Blockade of the metabotropic glutamate receptors by the specific antagonist, (RS)-alpha-Methyl-4-carboxyphenylglycine (500 microM) is shown to induce amnesia during a long-term memory stage in day-old chicks trained on a passive avoidance task, and to have no effect on prelong-term stages."	3.69	Blockade of metabotropic glutamate receptors prevents long-term memory consolidation. ( Ng, KT; Rickard, NS, 1995)
"We investigated the interrelationship of delayed amnesia, delayed neuronal death and changes in acetylcholine concentration induced by carbon monoxide (CO)-exposure in mice."	3.68	Carbon monoxide-induced delayed amnesia, delayed neuronal death and change in acetylcholine concentration in mice. ( Fukuta, T; Inari, K; Ishimaru, H; Kameyama, T; Katoh, A; Murase, K; Nabeshima, T; Ogita, K; Ohtsuka, H; Yoneda, Y, 1991)
" Increasing glycine concentrations in the brain by administration of a glycine prodrug, milacemide, is shown here to enhance performance of a shock-motivated passive avoidance task in rats, and to reverse drug-induced amnesia in a spontaneous alternation paradigm in mice."	3.67	Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents. ( Arnolde, SM; Cordi, AA; Handelmann, GE; Mueller, LL; Nevins, ME, 1989)

Research

Studies (8)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (12.50)	18.7374
1990's	4 (50.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	1 (12.50)	24.3611
2020's	1 (12.50)	2.80

Authors	Studies
Solntseva, SV	1
Kozyrev, SA	1
Nikitin, VP	1
Krystal, JH	1
Petrakis, IL	1
Limoncelli, D	1
Nappi, SK	1
Trevisan, L	1
Pittman, B	1
D'Souza, DC	1
Suckow, RF	1
Sato, T	1
Tanaka, K	1
Ohnishi, Y	1
Irifune, M	1
Nishikawa, T	1
Rickard, NS	1
Ng, KT	1
Hölscher, C	1
Maurice, T	1
Lockhart, BP	1
Su, TP	1
Privat, A	1
Nabeshima, T	1
Katoh, A	1
Ishimaru, H	1
Yoneda, Y	1
Ogita, K	1
Murase, K	1
Ohtsuka, H	1
Inari, K	1
Fukuta, T	1
Kameyama, T	1
Handelmann, GE	1
Nevins, ME	1
Mueller, LL	1
Arnolde, SM	1
Cordi, AA	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Glycine and Oral D-Cycloserine in Alcoholic Patients and Healthy Subjects[NCT00635102]		57 participants (Actual)	Interventional	1997-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol) (NCT00635102)
Timeframe: 120 minutes

Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.19	8	9.05	5.24
Healthy Subjects	1.30	1.667	2.08	2.08

Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.5	9	10.48	5.71
Healthy Subjects	1.82	2.17	1.67	2.08

Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	7.27	8.5	6.67	4.76
Healthy Subjects	2.61	1.67	3.04	1.25

Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	7.62	9.5	5	7.62
Healthy Subjects	3.04	2.5	1.67	0

Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	9.05	9	8	5.71
Healthy Subjects	1.82	2.17	2.5	2.08

Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 120 minutes

Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	8.57	9.5	9.05	6.19
Healthy Subjects	1.14	1.67	0.42	0.83

Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	12.38	8.95	9.5	8.57
Healthy Subjects	1.82	1.74	0.42	0.42

Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.5	10.5	9.05	6.19
Healthy Subjects	1.36	1.74	0.42	0.83

Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.36	8.95	7.14	10.48
Healthy Subjects	1.30	1.25	0.44	0.42

Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	8.1	12.5	7.73	8.10
Healthy Subjects	2.61	1.67	0.42	0.42

Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 120 minutes

Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.19	7	8.57	7.62
Healthy Subjects	0.87	0.83	0.42	0.42

Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	11.43	8	10.5	6.67
Healthy Subjects	0.91	0.87	0.42	0.42

Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	5.5	8.5	8.1	6.67
Healthy Subjects	0.46	0.87	0.83	0.83

Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	7.73	8	7.62	6.19
Healthy Subjects	0.87	0.83	1.30	0.42

Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.67	10.5	6.82	8.10
Healthy Subjects	1.74	0.42	0.42	0

Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 120 minutes

Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	34.29	33.5	30.48	36.67
Healthy Subjects	98.26	99.17	99.17	99.17

Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 30 minutes

Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	32.86	36	36.5	36.67
Healthy Subjects	99.1	98.70	99.17	99.17

Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 60 minutes

Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	34	39.5	25.71	37.14
Healthy Subjects	99.1	99.13	99.17	99.17

Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: 60 minutes prior to Glycine infusion

Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	30.46	40.5	36.67	42.86
Healthy Subjects	98.26	95	99.13	99.17

Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) (NCT00635102)
Timeframe: Baseline

Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	29.05	35.5	42.27	41.43
Healthy Subjects	93.48	94.58	99.17	98.75

Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol (NCT00635102)
Timeframe: 60 minutes prior to Glycine infusion

Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	6.23	6.6	7.24	4.57
Healthy Subjects	7.39	3.79	6.25	3.67

Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol (NCT00635102)
Timeframe: 120 minutes

Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	3.57	4.35	4	3.71
Healthy Subjects	4.13	1.67	3.04	1.25

Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol (NCT00635102)
Timeframe: 30 minutes

Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	7.14	5.8	5.2	4.62
Healthy Subjects	10.05	5.87	7.04	3.58

Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol (NCT00635102)
Timeframe: 60 minutes

Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	5.29	5.65	8.48	4.14
Healthy Subjects	9.64	5.83	8.54	2.54

Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol (NCT00635102)
Timeframe: Baseline

Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	3.41	3.3	3.57	5
Healthy Subjects	1.91	2.75	1.83	1.88

gordon diagnostic system is a continuous performance task (CPT) to measure distractibility - (A-Prime score range 0 minimum - 1 maximum - the higher number the better the performance) (NCT00635102)
Timeframe: 30 minutes

Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.93	0.97	0.90	0.96
Healthy Subjects	0.1	0.1	0.1	0.1

gordon diagnostic system is a continuous performance task (CPT) to measure Vigilance - (A-Prime score range 0 minimum - 1 maximum - The higher number the better the performance) (NCT00635102)
Timeframe: 30 minutes

Hopkins Verbal Learning Task - Delay Recall - 90 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.98	0.1	0.1	0.99
Healthy Subjects	0.1	0.1	0.1	0.1

Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (delay recall - 30 minutes after Trials 1-3 were given) (0 No words recalled - 12 all words recalled) (NCT00635102)
Timeframe: 90 minutes

Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	5.1	7.75	6.29	8.25
Healthy Subjects	9.7	10.87	10.21	11.38

Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (Three immediate recall trials) (0 No words recalled - 12 all words recalled) (NCT00635102)
Timeframe: 60 minutes - Trial 1

Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	5.29	6.05	5.48	5.95
Healthy Subjects	7.09	8.52	7.75	8.2

Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	7.67	8.45	7.1	8.67
Healthy Subjects	10.09	11.09	10.5	10.96

Number of Drinks Felt Consumed at 120 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	8	9.2	8.48	9.24
Healthy Subjects	10.57	11.48	11.17	11.67

The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. (NCT00635102)
Timeframe: 120 minutes

Number of Drinks Felt Consumed at 30 Minutes

Intervention	Number of Drinks Felt Consumed (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0	0.1	0.05	0
Healthy Subjects	0.13	0.21	0	0.04

The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. (NCT00635102)
Timeframe: 30 minutes

Number of Drinks Felt Consumed at 60 Minutes

Intervention	Number of Drinks Felt Consumed (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.38	0.20	0.38	0.24
Healthy Subjects	0.68	0.13	0.38	0.04

The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. (NCT00635102)
Timeframe: 60 minutes

Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion

Intervention	Number of Drinks Felt Consumed (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.05	0.5	0.86	0.05
Healthy Subjects	1.24	0.4	0.83	0.2

The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. (NCT00635102)
Timeframe: 60 minutes prior to Glycine infusion

Visual Analog Scales (VAS) - 120 Minutes

Intervention	drinks felt consumed (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.50	0.30	0.24	0.05
Healthy Subjects	0.70	0.25	0.75	0.22

Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) (NCT00635102)
Timeframe: 120 minutes

Visual Analog Scales (VAS) - 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.8	0.55	0.76	0.24
Healthy Subjects	0.35	0.21	0.29	0.25

Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) (NCT00635102)
Timeframe: 30 minutes

Visual Analog Scales (VAS) - 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.48	0.65	0.48	0.52
Healthy Subjects	1.05	0.30	0.79	0.25

Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) (NCT00635102)
Timeframe: 60 minutes

Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.52	0.8	0.6	0.19
Healthy Subjects	0.91	0.22	0.71	0.17

Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) (NCT00635102)
Timeframe: 60 minutes prior to Glycine infusion

Visual Analog Scales (VAS) - Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.64	0.68	0.48	0.38
Healthy Subjects	0.82	0.33	0.96	0.61

Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) (NCT00635102)
Timeframe: Baseline

Visual Analog Scales of Similarity to Alcohol - Baseline

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.32	0.5	0.76	0.48
Healthy Subjects	0.22	0.22	0.25	0.25

Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol (NCT00635102)
Timeframe: Baseline

Visual Analog Scales of Similarity to Alcohol 120 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.18	0.25	0.10	0.24
Healthy Subjects	0.05	0.04	0.04	0

Visual Analog Scales of Similarity to Alcohol 30 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.43	0.3	0.57	0.10
Healthy Subjects	0.41	0.09	0.29	0.33

Visual Analog Scales of Similarity to Alcohol 60 Minutes

Intervention	units on a scale (Mean)
	Glycine / Cycloserine	Glycine / Placebo	Placebo / Cycloserine	Placebo / Placebo
Alcoholic Subjects	0.57	0.60	1.05	0.43
Healthy Subjects	1.81	0.71	1.21	0.13

Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion

Article	Year
A Study of the Participation of NMDA Glutamate Receptors in the Mechanisms of Specific Anterograde Amnesia Reversion. Bulletin of experimental biology and medicine, 2020, Volume: 170, Issue:2 Topics: Amnesia; Amnesia, Anterograde; Animals; Avoidance Learning; Conditioning, Classical; Cycloserine; Di	2020
Effect of donepezil on group II mGlu receptor agonist- or antagonist-induced amnesia on passive avoidance in mice. Neural plasticity, 2003, Volume: 10, Issue:4 Topics: Amino Acids; Amnesia; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cyclopropanes; Donepez	2003
Blockade of metabotropic glutamate receptors prevents long-term memory consolidation. Brain research bulletin, 1995, Volume: 36, Issue:4 Topics: Amnesia; Animals; Avoidance Learning; Discrimination, Psychological; Dose-Response Relationship, Dru	1995
Inhibitors of metabotropic glutamate receptors produce amnestic effects in chicks. Neuroreport, 1994, May-09, Volume: 5, Issue:9 Topics: Aminobutyrates; Amnesia; Animals; Avoidance Learning; Benzoates; Chickens; Cycloleucine; Cyclopropan	1994
Reversion of beta 25-35-amyloid peptide-induced amnesia by NMDA receptor-associated glycine site agonists. Brain research, 1996, Aug-26, Volume: 731, Issue:1-2 Topics: Acetamides; Amnesia; Amyloid beta-Peptides; Animals; Antimetabolites; Avoidance Learning; Behavior,	1996
Carbon monoxide-induced delayed amnesia, delayed neuronal death and change in acetylcholine concentration in mice. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:1 Topics: Acetylcholine; Amnesia; Animals; Binding Sites; Brain; Carbon Monoxide; Cell Survival; Choline; Glut	1991
Milacemide, a glycine prodrug, enhances performance of learning tasks in normal and amnestic rodents. Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:4 Topics: Acetamides; Amnesia; Animals; Avoidance Learning; Benzamides; Exploratory Behavior; Glycine; Male; M	1989

glycine and Amnesia