Page last updated: 2024-10-18

glycine and Aging

glycine has been researched along with Aging in 249 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

Excerpt	Relevance	Reference
" By combining the benefits of glycine, NAC and GSH, GlyNAC is an effective nutritional supplement that improves and reverses multiple age-associated abnormalities to promote health in aging humans."	9.69	Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. ( Hsu, JW; Jahoor, F; Kumar, P; Liu, C; Minard, CG; Muthupillai, R; Sekhar, RV; Suliburk, J; Taffet, GE, 2023)
"We tested whether glutathione deficiency occurs because of diminished synthesis and contributes to oxidative stress in aging and whether stimulating glutathione synthesis with its precursors cysteine and glycine could alleviate oxidative stress."	9.15	Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. ( Balasubramanyam, A; Guthikonda, AP; Jahoor, F; Patel, SG; Reid, M; Sekhar, RV; Taffet, GE, 2011)
"To investigate the influence of nonvalvular atrial fibrillation (NVAF) on the pharmacokinetic (PK) properties of the oral direct thrombin inhibitor ximelagatran and its active form, melagatran."	9.10	Consistent pharmacokinetics of the oral direct thrombin inhibitor ximelagatran in patients with nonvalvular atrial fibrillation and in healthy subjects. ( Eriksson, UG; Grind, M; Svensson, M; Wåhlander, K; Wollbratt, M; Wolzt, M, 2003)
" The hyperhomocysteinemia, suppressed immunity, and altered oxidative metabolism observed in atherosclerosis and dementia are attributed to deficiency of adenosyl methionine which results from increased polyamine biosynthesis by pathogenic microbes that are demonstrated in atherosclerotic plaques and cerebral plaques."	9.05	Environmental Pollution, Oxidative Stress and Thioretinaco Ozonide: Effects of Glyphosate, Fluoride and Electromagnetic Fields on Mitochondrial Dysfunction in Carcinogenesis, Atherogenesis and Aging. ( McCully, KS, 2020)
"We assayed the redox forms of cysteine (reduced [CSH], oxidized [CSSC], and bound to protein [CS-SP]), cysteinylglycine (CGSH; cysteinylgycine disulfide [CGSSGC] and cysteinylglycine-protein mixed disulfide [CGS-SP]), glutathione (GSH; glutathione disulfide [GSSG] and glutathione-protein mixed disulfide [GS-SP]), homocysteine (Hcy; homocystine [HcyS] and homocystine-protein mixed disulfides [bHcy]), and protein sulfhydryls in the plasma of healthy subjects (divided into 8 groups ranging in age from birth to 70 years) and patients with mild hyperhomocysteinemia associated with cardiovascular disease (heart-transplant patients) or vascular atherosclerosis, with or without renal failure."	7.72	The effects of age and hyperhomocysteinemia on the redox forms of plasma thiols. ( Buonocore, G; Capecchi, PL; Cellesi, C; Di Giuseppe, D; Di Simplicio, FC; Di Simplicio, P; Frosali, S; Jakubowski, H; Lazzerini, PE; Pasini, FL; Priora, R, 2004)
"The release of preloaded [3H]glycine from hippocampal slices from 7-day-old and 3-month-old (adult) mice was studied in different cell-damaging conditions, including hypoxia, hypoglycemia, ischemia, oxidative stress and the presence of free radicals and metabolic poisons, using a superfusion system."	7.71	Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse. ( Oja, SS; Saransaari, P, 2001)
" The behavioral response to the administration of the glycine antagonist, strychnine, was also evaluated in 2- and 24-month-old animals to investigate the relevance of these parameters to the susceptibility to seizures."	7.67	Age-dependent changes in brain glycine concentration and strychnine-induced seizures in the rat. ( Chung, E; Hunter, C; Van Woert, MH, 1989)
"The incorporation of 15N-glycine into urinary uric acid was studied in three gouty patients, repeating a study carried out 13 to 27 years ago."	7.66	Long-term follow-up of incorporation of 15N from glycine into uric acid in gout. ( Roboz, J; Yu, TF, 1981)
" By combining the benefits of glycine, NAC and GSH, GlyNAC is an effective nutritional supplement that improves and reverses multiple age-associated abnormalities to promote health in aging humans."	5.69	Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. ( Hsu, JW; Jahoor, F; Kumar, P; Liu, C; Minard, CG; Muthupillai, R; Sekhar, RV; Suliburk, J; Taffet, GE, 2023)
"Elastin is a protein of the extracellular matrix that forms the major component of elastic fibers from the arterial wall thickness and plays an important role in elastic properties of large blood vessels."	5.31	Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans. ( Bortolotto, LA; Girerd, X; Hanon, O; Jeunemaitre, X; Luong, V; Mourad, JJ, 2001)
"Glycine was not able to reduce the absolute difference in [3H]glutamate binding to NMDA sites between 3- and 24-month-olds."	5.29	Glycine enhances binding to the NMDA receptor complex in aged mice, but does not correct the aging change. ( Magnusson, KR, 1996)
"The association between hippurate excretion and antioxidant biomarkers along with the relationship between phenylacetylglycine excretion and oxidant biomarkers suggests that the long-term consumption of a Med + CoQ diet could be beneficial for healthy aging and a promising challenge in the prevention of processes related to chronic oxidative stress, such as cardiovascular and neurodegenerative disease."	5.20	Effects of the Mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women. ( Brennan, L; Camargo, A; Delgado-Casado, N; Delgado-Lista, J; Garcia-Rios, A; González-Guardia, L; López-Miranda, J; Marin, C; Perez-Jimenez, F; Perez-Martinez, P; Roche, HM; Yubero-Serrano, EM, 2015)
"We tested whether glutathione deficiency occurs because of diminished synthesis and contributes to oxidative stress in aging and whether stimulating glutathione synthesis with its precursors cysteine and glycine could alleviate oxidative stress."	5.15	Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. ( Balasubramanyam, A; Guthikonda, AP; Jahoor, F; Patel, SG; Reid, M; Sekhar, RV; Taffet, GE, 2011)
"To investigate the influence of nonvalvular atrial fibrillation (NVAF) on the pharmacokinetic (PK) properties of the oral direct thrombin inhibitor ximelagatran and its active form, melagatran."	5.10	Consistent pharmacokinetics of the oral direct thrombin inhibitor ximelagatran in patients with nonvalvular atrial fibrillation and in healthy subjects. ( Eriksson, UG; Grind, M; Svensson, M; Wåhlander, K; Wollbratt, M; Wolzt, M, 2003)
" The hyperhomocysteinemia, suppressed immunity, and altered oxidative metabolism observed in atherosclerosis and dementia are attributed to deficiency of adenosyl methionine which results from increased polyamine biosynthesis by pathogenic microbes that are demonstrated in atherosclerotic plaques and cerebral plaques."	5.05	Environmental Pollution, Oxidative Stress and Thioretinaco Ozonide: Effects of Glyphosate, Fluoride and Electromagnetic Fields on Mitochondrial Dysfunction in Carcinogenesis, Atherogenesis and Aging. ( McCully, KS, 2020)
"We assayed the redox forms of cysteine (reduced [CSH], oxidized [CSSC], and bound to protein [CS-SP]), cysteinylglycine (CGSH; cysteinylgycine disulfide [CGSSGC] and cysteinylglycine-protein mixed disulfide [CGS-SP]), glutathione (GSH; glutathione disulfide [GSSG] and glutathione-protein mixed disulfide [GS-SP]), homocysteine (Hcy; homocystine [HcyS] and homocystine-protein mixed disulfides [bHcy]), and protein sulfhydryls in the plasma of healthy subjects (divided into 8 groups ranging in age from birth to 70 years) and patients with mild hyperhomocysteinemia associated with cardiovascular disease (heart-transplant patients) or vascular atherosclerosis, with or without renal failure."	3.72	The effects of age and hyperhomocysteinemia on the redox forms of plasma thiols. ( Buonocore, G; Capecchi, PL; Cellesi, C; Di Giuseppe, D; Di Simplicio, FC; Di Simplicio, P; Frosali, S; Jakubowski, H; Lazzerini, PE; Pasini, FL; Priora, R, 2004)
" Using Ca(2+) imaging and patch clamp in a flat-mount perinatal rabbit retinal preparation, this study demonstrates that, in addition to the cholinergic system, a strychnine-sensitive system in the inner retina plays an obligatory and developmentally regulated role in the initiation and propagation of spontaneous retinal waves."	3.71	A critical role of the strychnine-sensitive glycinergic system in spontaneous retinal waves of the developing rabbit. ( Zhou, ZJ, 2001)
"The release of preloaded [3H]glycine from hippocampal slices from 7-day-old and 3-month-old (adult) mice was studied in different cell-damaging conditions, including hypoxia, hypoglycemia, ischemia, oxidative stress and the presence of free radicals and metabolic poisons, using a superfusion system."	3.71	Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse. ( Oja, SS; Saransaari, P, 2001)
" Urea concentrations in amniotic and allantoic fluids progressively increased during the second half of pregnancy, indicating enhanced fetal protein metabolism."	3.69	Developmental changes of free amino acid concentrations in fetal fluids of pigs. ( Bazer, FW; Tou, W; Wu, G, 1995)
"The present study used quantitative receptor autoradiography to examine the effects of aging on the binding profile of the strychnine-sensitive glycine receptor in the Fischer 344 rat."	3.69	Age-related reduction of [3H]strychnine binding sites in the cochlear nucleus of the Fischer 344 rat. ( Caspary, DM; Milbrandt, JC, 1995)
" The aminothiol compound cysteamine (CSH) induces the appearance of autofluorescent, iron-rich cytoplasmic granules in cultured astroglia that are identical to glial inclusions that progressively accumulate in the aging periventricular brain."	3.69	A cellular stress model for the sequestration of redox-active glial iron in the aging and degenerating nervous system. ( Manganaro, F; Schipper, HM; Wang, X, 1995)
" The behavioral response to the administration of the glycine antagonist, strychnine, was also evaluated in 2- and 24-month-old animals to investigate the relevance of these parameters to the susceptibility to seizures."	3.67	Age-dependent changes in brain glycine concentration and strychnine-induced seizures in the rat. ( Chung, E; Hunter, C; Van Woert, MH, 1989)
"The incorporation of 15N-glycine into urinary uric acid was studied in three gouty patients, repeating a study carried out 13 to 27 years ago."	3.66	Long-term follow-up of incorporation of 15N from glycine into uric acid in gout. ( Roboz, J; Yu, TF, 1981)
"Glycine is a well-known free radical scavenger in the cellular antioxidant system that prevents oxidative damage and apoptosis."	1.62	Glycine alleviates fluoride-induced oxidative stress, apoptosis and senescence in a porcine testicular Sertoli cell line. ( Bai, C; Li, J; Liang, S; Liu, Y; Qi, J; Sun, B; Zhang, J; Zhang, S, 2021)
"Glycine treatment improved this modulator effect and increased relaxation to acetylcholine."	1.42	Vascular endothelial function is improved by oral glycine treatment in aged rats. ( Cruz, M; García-Macedo, R; Gómez-Zamudio, JH; Ibarra-Barajas, M; Kumate, J; Lázaro-Suárez, M, 2015)
"The oxytocin effect was mediated by uterine-type oxytocin receptors."	1.36	Oxytocin and vasopressin enhance synaptic transmission in the hypoglossal motor nucleus of young rats by acting on distinct receptor types. ( Dupré, A; Raggenbass, M; Reymond-Marron, I; Wrobel, LJ, 2010)
"Adenosine is a neuromodulator which inhibits the synaptic release of neurotransmitters."	1.35	Effects of inhibitory amino acids on adenosine release in the mouse hippocampus. ( Oja, SS; Saransaari, P, 2008)
"Glycine responses were reduced by preapplication of taurine; this effect was more pronounced in cells lacking the alpha3-subunit."	1.31	Expression and function of glycine receptors in striatal cholinergic interneurons from rat and mouse. ( Haas, HL; Sergeeva, OA, 2001)
"Elastin is a protein of the extracellular matrix that forms the major component of elastic fibers from the arterial wall thickness and plays an important role in elastic properties of large blood vessels."	1.31	Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans. ( Bortolotto, LA; Girerd, X; Hanon, O; Jeunemaitre, X; Luong, V; Mourad, JJ, 2001)
"[3H]Muscimol binding was the highest in the cerebellum, and decreased in many brain regions in aged rats."	1.30	Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains. ( Araki, T; Chen, T; Hiranuma, T; Itoyama, Y; Kato, H; Kogure, K; Liu, XH; Murase, K, 1997)
" Dose-response curves were right-shifted by aging (twice the dose was required to achieve the same enhancement compared with controls)."	1.30	Age- and dose-dependent facilitation of associative eyeblink conditioning by D-cycloserine in rabbits. ( Disterhoft, JF; Thompson, LT, 1997)
"Glycine and taurine were present at relatively low concentrations during the prenatal period, then rose significantly by about 4-fold after birth; their levels decreased by the end of the first postnatal week but increased gradually thereafter until reaching adult values by the third week."	1.30	Levels of amino acid neurotransmitters during mouse cerebellar neurogenesis and in histotypic cerebellar cultures. ( Benítez-Diaz, PR; Delgado-Saez, MC; Mendoza-Briceño, RV; Miranda-Contreras, L; Palacios-Prü, EL, 1999)
"Seizures were induced once a day for 3 consecutive days, either from post-natal day 5 (P5) to P7 or from P15 to P17."	1.30	Repeated seizure-associated long-lasting changes of N-methyl-D-aspartate receptor properties in the developing rat brain. ( Daval, JL; Doriat, JF; Humbert, AC; Koziel, V, 1999)
"Glycine was not able to reduce the absolute difference in [3H]glutamate binding to NMDA sites between 3- and 24-month-olds."	1.29	Glycine enhances binding to the NMDA receptor complex in aged mice, but does not correct the aging change. ( Magnusson, KR, 1996)
"The glycine effect was strychnine-insensitive, characteristic of the glycine modulatory site in the N-methyl-D-aspartate receptor."	1.29	Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice. ( Oja, SS; Saransaari, P, 1994)
"Glycine substitutions have been the most common types of mutation."	1.29	Phenotypic expressions of a Gly 154Arg mutation in type II collagen in two unrelated patients with spondyloepimetaphyseal dysplasia (SEMD). ( Ala-Kokko, L; Kaitila, I; Körkkö, J; Marttinen, E, 1996)
"beta-Alanine was a noncompetitive inhibitor."	1.29	Strychnine-insensitive glycine binding to cerebral cortical membranes in developing and ageing mice. ( Oja, SS; Saransaari, P, 1993)
"The geriatric trauma (GT) group lost less N (11."	1.29	Protein and glucose fuel kinetics and hormonal changes in elderly trauma patients. ( Jeevanandam, M; Petersen, SR; Shamos, RF, 1993)
"The glycine receptor also has fetal (alpha 2) and adult (alpha 1) isoforms."	1.28	Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels. ( Akagi, H; Hirai, K; Hishinuma, F; Momiyama, A; Takahashi, T, 1992)
"3H-glycine binding sites were most concentrated in the hippocampus, cerebral cortex, and olfactory tubercle, and moderate densities of binding sites were located in the striatum, nucleus accumbens, amygdala, and certain thalamic nuclei."	1.28	Age-related changes of strychnine-insensitive glycine receptors in rat brain as studied by in vitro autoradiography. ( Doudou, N; Kito, S; Miyoshi, R; Nomoto, T, 1990)
"[3H]-glycine binding sites were severely decreased in the telencephalic regions, including the hippocampus and cerebral cortex, in aged brain."	1.28	Influence of age on NMDA receptor complex in rat brain studied by in vitro autoradiography. ( Kito, S; Miyoshi, R; Nomoto, T, 1990)
"The glycine inhibition was stronger in adult than in developing mice."	1.27	Glycinergic systems in the brain stem of developing and adult mice: effects of taurine. ( Kontro, P; Oja, SS, 1987)

Research

Studies (249)

Timeframe	Studies, this research(%)	All Research%
pre-1990	75 (30.12)	18.7374
1990's	83 (33.33)	18.2507
2000's	46 (18.47)	29.6817
2010's	39 (15.66)	24.3611
2020's	6 (2.41)	2.80

Authors

Authors	Studies
Kumar, P	2
Liu, C	2
Suliburk, J	1
Hsu, JW	2
Muthupillai, R	1
Jahoor, F	3
Minard, CG	1
Taffet, GE	3
Sekhar, RV	5
Johnson, AA	1
Cuellar, TL	1
Olah, A	1
Stajer, V	1
Ratgeber, L	1
Betlehem, J	1
Ostojic, SM	1
Zanardi, MV	1
Schimpf, MG	1
Gastiazoro, MP	1
Milesi, MM	1
Muñoz-de-Toro, M	1
Varayoud, J	1
Durando, M	1
Morón-Oset, J	1
Supèr, T	1
Esser, J	1
Isaacs, AM	1
Grönke, S	1
Partridge, L	1
McCully, KS	1
Liu, Y	2
Sun, B	1
Zhang, S	1
Li, J	2
Qi, J	1
Bai, C	1
Zhang, J	1
Liang, S	1
Chacko, S	1
Minard, C	1
Godfrey, DA	1
Chen, K	1
O'Toole, TR	1
Mustapha, AIAA	1
Brodsky, VY	1
Malchenko, LA	1
Butorina, NN	1
Lazarev Konchenko, DS	1
Zvezdina, ND	1
Dubovaya, TK	1
Cieslik, KA	1
Granillo, A	1
Reddy, A	1
Medrano, G	1
Heredia, CP	1
Entman, ML	1
Hamilton, DJ	1
Li, S	1
Reineke, E	1
Gupte, AA	1
Zhang, A	1
Peron, G	1
Dall'Acqua, S	1
Sut, S	1
Shimizu, A	2
Mitani, T	1
Tanaka, S	1
Fujii, H	1
Maebuchi, M	1
Amiya, Y	1
Tanaka, M	1
Matsui, T	1
Nakamura, S	1
Katayama, S	1
Billard, JM	3
Freret, T	1
Vieira, DVG	1
Silva, JHV	1
Costa, FGP	1
Melo, TS	1
Lima, MR	1
Cavalcante, DT	1
de Vargas Júnior, JG	1
Bonaparte, TP	1
Oliveira, LC	1
Davydova, TV	1
Gruden, MA	1
Kudrin, VS	1
Narkevich, VB	1
Vetrile, LA	1
Zakharova, IA	1
Sewell, RDE	1
Liu, YJ	1
Janssens, GE	1
McIntyre, RL	1
Molenaars, M	1
Kamble, R	1
Gao, AW	1
Jongejan, A	1
Weeghel, MV	1
MacInnes, AW	1
Houtkooper, RH	1
Miller, RA	1
Harrison, DE	1
Astle, CM	1
Bogue, MA	1
Brind, J	1
Fernandez, E	1
Flurkey, K	1
Javors, M	1
Ladiges, W	1
Leeuwenburgh, C	1
Macchiarini, F	1
Nelson, J	1
Ryazanov, AG	1
Snyder, J	1
Stearns, TM	1
Vaughan, DE	1
Strong, R	1
Nguyen, D	1
Samson, SL	1
Reddy, VT	1
Gonzalez, EV	1
Blankenship, ML	1
Baccei, ML	1
Yang, S	1
Megill, A	1
Ardiles, AO	1
Ransom, S	1
Tran, T	1
Koh, MT	1
Lee, HK	1
Gallagher, M	1
Kirkwood, A	1
Timmer, NM	1
Metaxas, A	1
van der Stelt, I	1
Kluijtmans, LA	1
van Berckel, BN	1
Verbeek, MM	1
Kumar, A	1
Foster, TC	1
González-Guardia, L	1
Yubero-Serrano, EM	1
Delgado-Lista, J	1
Perez-Martinez, P	1
Garcia-Rios, A	1
Marin, C	1
Camargo, A	1
Delgado-Casado, N	1
Roche, HM	1
Perez-Jimenez, F	1
Brennan, L	1
López-Miranda, J	1
Longo, F	1
Russo, I	1
Shimshek, DR	1
Greggio, E	1
Morari, M	1
Drachuk, KO	2
Kotsiuruba, AV	1
Baziliuk, OV	1
Stepanenko, LH	1
Sahach, VF	1
DiMauro, MA	1
Nandi, SK	1
Raghavan, CT	1
Kar, RK	1
Wang, B	1
Bhunia, A	1
Nagaraj, RH	1
Biswas, A	1
Gómez-Zamudio, JH	1
García-Macedo, R	1
Lázaro-Suárez, M	1
Ibarra-Barajas, M	1
Kumate, J	1
Cruz, M	1
Hashizume, O	1
Ohnishi, S	1
Mito, T	1
Ishikawa, K	1
Iashikawa, K	1
Nakada, K	1
Soda, M	1
Mano, H	1
Togayachi, S	1
Miyoshi, H	1
Okita, K	1
Hayashi, J	1
Sharideh, H	1
Esmaeile Neia, L	1
Zaghari, M	1
Zhandi, M	1
Akhlaghi, A	1
Lotfi, L	1
Dorofeyeva, NA	1
Kotsjuruba, AV	1
Sagach, VF	1
Saska, P	1
Skuhrovec, J	1
Lukáš, J	1
Chi, H	1
Tuan, SJ	1
Honěk, A	1
Cieslak, KP	1
Baur, O	1
Verheij, J	1
Bennink, RJ	1
van Gulik, TM	1
Cholewa, JM	1
Dardevet, D	1
Lima-Soares, F	1
de Araújo Pessôa, K	1
Oliveira, PH	1
Dos Santos Pinho, JR	1
Nicastro, H	1
Xia, Z	1
Cabido, CE	1
Zanchi, NE	1
Wang, W	1
Zhang, Z	1
Shang, J	1
Jiang, ZZ	1
Wang, S	1
Zhang, LY	1
Oja, SS	9
Saransaari, P	8
Wrobel, LJ	1
Reymond-Marron, I	1
Dupré, A	1
Raggenbass, M	1
Schmidt, B	1
de Assis, AM	1
Battu, CE	1
Rieger, DK	1
Hansen, F	1
Sordi, F	1
Longoni, A	1
Hoefel, AL	1
Farina, M	1
Gonçalves, CA	1
Souza, DO	2
Perry, ML	2
Rajalu, M	1
Müller, UC	1
Caley, A	1
Harvey, RJ	1
Poisbeau, P	2
STERN, K	1
ASKONAS, BA	1
Whiteley, P	1
Haracopos, D	1
Knivsberg, AM	1
Reichelt, KL	1
Parlar, S	1
Jacobsen, J	1
Seim, A	1
Pedersen, L	1
Schondel, M	1
Shattock, P	1
Karnani, MM	1
Venner, A	1
Jensen, LT	1
Fugger, L	1
Burdakov, D	1
Gao, XP	1
Liu, QS	1
Liu, Q	1
Wong-Riley, MT	1
Patel, SG	1
Guthikonda, AP	1
Reid, M	1
Balasubramanyam, A	1
Molina, DP	1
Ariwodola, OJ	1
Linville, C	1
Sonntag, WE	1
Weiner, JL	1
Brunso-Bechtold, JK	1
Adams, MM	1
Borghese, CM	1
Xiong, W	1
Oh, SI	1
Ho, A	1
Mihic, SJ	1
Zhang, L	1
Lovinger, DM	1
Homanics, GE	1
Eger, EI	1
Harris, RA	1
Matrone, C	1
Luvisetto, S	1
La Rosa, LR	1
Tamayev, R	1
Pignataro, A	1
Canu, N	1
Yang, L	1
Barbagallo, AP	1
Biundo, F	1
Lombino, F	1
Zheng, H	1
Ammassari-Teule, M	1
D'Adamio, L	1
Dilger, RN	1
Bryant-Angeloni, K	1
Payne, RL	1
Lemme, A	1
Parsons, CM	1
McQuail, JA	1
Davis, KN	1
Miller, F	1
Hampson, RE	1
Deadwyler, SA	1
Howlett, AC	1
Nicolle, MM	1
Kraushaar, U	1
Backus, KH	2
Kim, G	1
Kandler, K	2
Balakrishnan, V	1
Becker, M	1
Löhrke, S	3
Nothwang, HG	1
Güresir, E	1
Friauf, E	6
Wolzt, M	1
Wollbratt, M	1
Svensson, M	1
Wåhlander, K	1
Grind, M	1
Eriksson, UG	1
VIOLA, S	1
CITI, S	1
LEONE, O	1
SALVINI, L	1
GRANDONICO, F	1
BALIS, ME	1
SAMARTH, K	1
BIELECKI, B	1
BENTOR, V	1
WERTHEIMER, HE	1
WENDER, M	1
WALIGORA, Z	1
TONNA, EA	1
MIURA, Y	1
ITO, H	1
SUNAGA, K	1
IKEDA, K	1
MORIYAMA, Y	1
HASEGAWA, S	1
BRANDT, IK	1
BEAUMONT, JL	1
SCHWARTZ, D	1
MANKIN, HJ	1
BARON, PA	1
Kies, C	1
Williams, E	1
Fox, HM	1
KAO, KY	1
VERNIER, CM	1
MCGAVACK, TH	1
Turner, BJ	1
Lopes, EC	1
Cheema, SS	1
Gleich, O	2
Weiss, M	1
Strutz, J	2
Milner, AJ	1
Cummings, DM	1
Spencer, JP	1
Murphy, KP	1
de Souza, KB	1
Feoli, AM	1
Krüger, AH	1
de Souza, MR	1
Perry, CT	1
Rotta, LN	1
Di Giuseppe, D	1
Frosali, S	1
Priora, R	1
Di Simplicio, FC	1
Buonocore, G	1
Cellesi, C	1
Capecchi, PL	1
Pasini, FL	1
Lazzerini, PE	1
Jakubowski, H	1
Di Simplicio, P	1
Almaguer-Melian, W	1
Cruz-Aguado, R	1
Riva, Cde L	1
Kendrick, KM	1
Frey, JU	1
Bergado, J	1
Sastre, J	1
Martín, JA	1
Gómez-Cabrera, MC	1
Pereda, J	1
Borrás, C	1
Pallardó, FV	1
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Caspary, DM	3
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Clinical Trials (6)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Glutathione and Fuel Oxidation in Aging[NCT01870193]	Early Phase 1	36 participants (Anticipated)	Interventional	2013-04-23	Completed
Controlled and Randomized Clinical Trial for Evaluating the Effect of a Supplement of Glycine as Adjuvant in the Treatment of COVID-19 Pneumonia in Patients Initiating Mechanical Ventilation[NCT04443673]		59 participants (Actual)	Interventional	2020-06-15	Terminated (stopped due to An interim analysis showed no difference in major outcomes (n=35 glycine and n=24 control participants))
The Effect of Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults[NCT06157385]		46 participants (Anticipated)	Interventional	2023-05-06	Recruiting
The ScanBrit Randomised Controlled Study of Gluten- and Casein-free Dietary Intervention for Children With Autism Spectrum Disorders[NCT00614198]	Phase 2	72 participants (Actual)	Interventional	2006-04-30	Completed
A1 Beta Casein Free Milk (a2 Milk) for Autism and Attention-deficit Hyperactivity Disorder[NCT02911194]		40 participants (Actual)	Interventional	2016-09-30	Completed
Central Nervous System Uptake of Intranasal Glutathione in Parkinson's Disease[NCT02324426]	Phase 1	15 participants (Actual)	Interventional	2014-12-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Diet Groups Scores on One of Several Measures Used Against Pre-defined Statistical Thresholds as Evidence of Improvement.

ADOS (Autism Diagnostic Observation Schedule): module 1 cutoff scores (communication+social): autism=12, autism spectrum (AS)=7; module 2 cutoffs: autism=12, AS=8; module 3 cutoffs: autism=10; AS=7. GARS (Gilliam Autism Rating Scale): <80 low probability of autism, 81-90 below average, 91-110 average, >110 above average probability of autism. VABS (Vineland Adaptive Behaviour Scale): <69 (low ability), 70-84 (moderate/low), 85-115 (adequate), 116-130 (moderate/high), >130 (high). ADHD-IV: 0=no problems indicated. >11 attention & >11 hyperactivity = ADHD diagnosis. (NCT00614198)
Timeframe: Baseline - 8 months - 12 months - 24 months

Intervention	Units on a scale (Mean)
	ADOS - Communication (8 months)	ADOS - Communication (24 months)	ADOS - Social (8 months)	ADOS - Social (24 months)	ADOS - Repetitive behaviours (8 months)	ADOS - Reptitive behaviours (24 months)	GARS - Social (8 months)	GARS - Social (12 months)	GARS - Social (24 months)	GARS - Communication (8 months)	GARS - Communication (12 months)	GARS - Communication (24 months)	GARS - Stereotyped behaviours (8 months)	GARS - Stereotyped behaviours (12 months)	GARS - Stereotyped behaviours (24 months)	VABS - Communication (8 months)	VABS - Communication (12 months)	VABS - Communication (24 months)	VABS - Social (8 months)	VABS - Social (12 months)	VABS - Social (24 months)	VABS - Daily Living (8 months)	VABS - Daily Living (12 months)	VABS - Daily Living (24 months)	ADHD-IV - Inattention (8 months)	ADHD-IV - Inattention (12 months)	ADHD-IV - Inattention (24 months)	ADHD-IV - Hyperactivity (8 months)	ADHD-IV - Hyperactivity (12 months)	ADHD-IV Hyperactivity (24 months)
Gluten- and Casein-free Dietary Intervention	-0.16715	-0.16176	0.016807	-0.5042	-0.14706	-0.14216	-1.07692	-1.57692	-1.88235	-1.23077	-1.47826	-2	-0.96154	-1.46154	-0.88235	0.23077	0.92308	1.27778	1.53846	-4.15385	0.72222	3.03846	3.46154	-0.16667	-2.15385	-2.19231	-2.29412	-2.03846	-1.69231	-2.58824
No Gluten- and Casein-free Dietary Intervention	0.08235	0.18529	0.02521	0.02521	0.03431	-0.0049	-0.06897	-0.42308	-1.11765	-0.51724	-1.46154	-1.29412	-0.7931	-1.3333	-1.70588	1.25	1.85714	-2.05882	0.92857	-3.25	-3.29412	-1.64286	-2.85714	-4.64706	0.31034	-0.03704	-3.35294	-0.17241	-0.92593	-4.17647

Reviews

8 reviews available for glycine and Aging

Article	Year
Glycine and aging: Evidence and mechanisms. Ageing research reviews, 2023, Volume: 87 Topics: Aging; Animals; Glycine; Glycine N-Methyltransferase; Humans; Longevity; Mammals; Methionine; Mice;	2023
Environmental Pollution, Oxidative Stress and Thioretinaco Ozonide: Effects of Glyphosate, Fluoride and Electromagnetic Fields on Mitochondrial Dysfunction in Carcinogenesis, Atherogenesis and Aging. Annals of clinical and laboratory science, 2020, Volume: 50, Issue:3 Topics: Aging; Animals; Atherosclerosis; Carcinogenesis; Electromagnetic Fields; Environmental Pollution; Fl	2020
Dietary proteins and amino acids in the control of the muscle mass during immobilization and aging: role of the MPS response. Amino acids, 2017, Volume: 49, Issue:5 Topics: Aging; Antioxidants; Betaine; Dietary Proteins; Dietary Supplements; Exercise; Glycine; Humans; Hypo	2017
Growth in fishes. Gerontology, 1994, Volume: 40, Issue:2-4 Topics: Aging; Animals; Diet; Environment; Female; Fishes; Glycine; Hormones; Male; Social Behavior; Tempera	1994
Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Mar-15, Volume: 18, Issue:6 Topics: Aging; Animals; Binding, Competitive; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glycine; N	1998
[Biologic properties of lipoic acid]. Postepy higieny i medycyny doswiadczalnej, 2002, Volume: 56, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Aging; Animals; Antioxidants; Cataract; Decarboxylation; Diabeti	2002
Central glycine-receptors. General pharmacology, 1978, Volume: 9, Issue:3 Topics: Aging; Animals; Binding, Competitive; Central Nervous System; Glycine; Receptors, Drug; Social Envir	1978
Neurotransmitter synthetic enzymes. Progress in neurobiology, 1973, Volume: 2, Issue:1 Topics: Acetylcholine; Acetyltransferases; Adenylyl Cyclases; Aging; Aminobutyrates; Animals; Brain; Brain C	1973

Trials

7 trials available for glycine and Aging

Article	Year
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. The journals of gerontology. Series A, Biological sciences and medical sciences, 2023, 01-26, Volume: 78, Issue:1 Topics: Acetylcysteine; Aged; Aging; Animals; Dietary Supplements; Glutathione; Glycine; Health Promotion; H	2023
Supplementation of L-glycine and L-glutamate to Japanese quails from 01 to 36 days of age using the ideal protein concept. Journal of animal physiology and animal nutrition, 2019, Volume: 103, Issue:1 Topics: Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Coturnix; Diet; Dietary Pro	2019
Effects of the Mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women. The journals of gerontology. Series A, Biological sciences and medical sciences, 2015, Volume: 70, Issue:1 Topics: Aged; Aging; Antioxidants; beta Carotene; Biomarkers; Cross-Over Studies; Diet, Mediterranean; Dieta	2015
Effect of feeding guanidinoacetic acid and L-arginine on the fertility rate and sperm penetration in the perivitelline layer of aged broiler breeder hens. Journal of animal physiology and animal nutrition, 2016, Volume: 100, Issue:2 Topics: Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Arginine; Chickens; Diet; F	2016
The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders. Nutritional neuroscience, 2010, Volume: 13, Issue:2 Topics: Aging; Attention; Caseins; Child; Child Development; Child Development Disorders, Pervasive; Child,	2010
The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders. Nutritional neuroscience, 2010, Volume: 13, Issue:2 Topics: Aging; Attention; Caseins; Child; Child Development; Child Development Disorders, Pervasive; Child,	2010
The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders. Nutritional neuroscience, 2010, Volume: 13, Issue:2 Topics: Aging; Attention; Caseins; Child; Child Development; Child Development Disorders, Pervasive; Child,	2010
The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders. Nutritional neuroscience, 2010, Volume: 13, Issue:2 Topics: Aging; Attention; Caseins; Child; Child Development; Child Development Disorders, Pervasive; Child,	2010
Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. The American journal of clinical nutrition, 2011, Volume: 94, Issue:3 Topics: Adult; Age Factors; Aged; Aging; Cysteine; Dietary Supplements; Erythrocytes; F2-Isoprostanes; Gluta	2011
Consistent pharmacokinetics of the oral direct thrombin inhibitor ximelagatran in patients with nonvalvular atrial fibrillation and in healthy subjects. European journal of clinical pharmacology, 2003, Volume: 59, Issue:7 Topics: Administration, Oral; Adult; Aged; Aging; Area Under Curve; Atrial Fibrillation; Azetidines; Benzyla	2003

Other Studies

234 other studies available for glycine and Aging

Article	Year
Age-Related Changes in Serum Guanidinoacetic Acid in Women. Physiological research, 2019, 12-30, Volume: 68, Issue:6 Topics: Adolescent; Adult; Aged; Aging; Biomarkers; Energy Metabolism; Exercise; Female; Glycine; Humans; In	2019
Glyphosate-based herbicide induces hyperplastic ducts in the mammary gland of aging Wistar rats. Molecular and cellular endocrinology, 2020, 02-05, Volume: 501 Topics: Aging; Animals; Animals, Newborn; Cell Proliferation; Estradiol; Female; Glycine; Glyphosate; Gonada	2020
Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. Acta neuropathologica communications, 2019, 12-16, Volume: 7, Issue:1 Topics: Aging; Alanine; Animals; Animals, Genetically Modified; Brain; C9orf72 Protein; Dipeptides; DNA Repe	2019
Glycine alleviates fluoride-induced oxidative stress, apoptosis and senescence in a porcine testicular Sertoli cell line. Reproduction in domestic animals = Zuchthygiene, 2021, Volume: 56, Issue:6 Topics: Adenosine Triphosphate; Aging; Animals; Apoptosis; Cell Line; Cell Survival; DNA Fragmentation; Gene	2021
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Re Clinical and translational medicine, 2021, Volume: 11, Issue:3 Topics: Acetylcysteine; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Cognition; Dietary Supplements;	2021
Amino acid and acetylcholine chemistry in the central auditory system of young, middle-aged and old rats. Hearing research, 2017, Volume: 350 Topics: Acetylcholine; Age Factors; Aging; Amino Acids; Animals; Aspartic Acid; Auditory Pathways; Brain; Ch	2017
Glutamic Acid as Enhancer of Protein Synthesis Kinetics in Hepatocytes from Old Rats. Biochemistry. Biokhimiia, 2017, Volume: 82, Issue:8 Topics: Aging; Animals; Cell Communication; Cells, Cultured; Cellular Senescence; Glutamic Acid; Glycine; He	2017
Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors. The journals of gerontology. Series A, Biological sciences and medical sciences, 2018, 08-10, Volume: 73, Issue:9 Topics: Acetylcysteine; Aging; Animals; Antioxidants; Cardiovascular Physiological Phenomena; Cellular Senes	2018
Supplementation with resveratrol as Polygonum cuspidatum Sieb. et Zucc. extract induces changes in the excretion of urinary markers associated to aging in rats. Fitoterapia, 2018, Volume: 129 Topics: Aging; Animals; Biomarkers; Chromatography, High Pressure Liquid; Fallopia japonica; Female; Glycine	2018
Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain. Journal of agricultural and food chemistry, 2018, Aug-01, Volume: 66, Issue:30 Topics: Aging; Animals; Arginine; Brain; Brain-Derived Neurotrophic Factor; Dipeptides; Female; Glycine; Gly	2018
Asc-1 transporter activation: an alternative to rescue age-related alterations in functional plasticity at rat hippocampal CA3/CA1 synapses. Journal of neurochemistry, 2018, Volume: 147, Issue:4 Topics: Aging; Amino Acid Transport System ASC; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; E	2018
Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice. Bulletin of experimental biology and medicine, 2019, Volume: 166, Issue:3 Topics: Administration, Intranasal; Aging; Animals; Antibodies; Aspartic Acid; Avoidance Learning; Condition	2019
Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PLoS genetics, 2019, Volume: 15, Issue:3 Topics: Aging; Animals; Caenorhabditis elegans; Diet; Genes, Helminth; Glycine; Longevity; Metabolic Network	2019
Glycine supplementation extends lifespan of male and female mice. Aging cell, 2019, Volume: 18, Issue:3 Topics: Adenomatosis, Pulmonary; Aging; Animals; Aspirin; Diet; Dietary Supplements; Female; Glycine; Inulin	2019
Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione. Aging cell, 2013, Volume: 12, Issue:3 Topics: Aging; Animals; Antioxidants; Body Composition; Cholesterol, LDL; Cholesterol, VLDL; Cysteine; Fatty	2013
Deficits in glycinergic inhibition within adult spinal nociceptive circuits after neonatal tissue damage. Pain, 2013, Volume: 154, Issue:7 Topics: Aging; Animals; Animals, Newborn; Female; Glycine; Mice; Mice, Transgenic; Neural Inhibition; Nocice	2013
Integrity of mGluR-LTD in the associative/commissural inputs to CA3 correlates with successful aging in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jul-31, Volume: 33, Issue:31 Topics: Age Factors; Aging; Animals; Biophysics; CA3 Region, Hippocampal; Cyclopropanes; Electric Stimulatio	2013
Cerebral level of vGlut1 is increased and level of glycine is decreased in TgSwDI mice. Journal of Alzheimer's disease : JAD, 2014, Volume: 39, Issue:1 Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoradiog	2014
Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses. Hippocampus, 2014, Volume: 24, Issue:4 Topics: Aging; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Calcium Channel Blockers; Calcium	2014
Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging. Neurobiology of disease, 2014, Volume: 71 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Analysis of Variance; Animals; Brain; Dose-Res	2014
[Propargylglycine restores endothelium-dependent relaxation of aortic smooth muscles in old rats]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2014, Volume: 60, Issue:4 Topics: Aging; Alkynes; Animals; Aorta, Thoracic; Cystathionine gamma-Lyase; Endothelium, Vascular; Enzyme I	2014
Acetylation of Gly1 and Lys2 promotes aggregation of human γD-crystallin. Biochemistry, 2014, Nov-25, Volume: 53, Issue:46 Topics: Acetylation; Aged; Aging; Amino Acid Sequence; Cataract; gamma-Crystallins; Glycine; Humans; Lysine;	2014
Vascular endothelial function is improved by oral glycine treatment in aged rats. Canadian journal of physiology and pharmacology, 2015, Volume: 93, Issue:6 Topics: Acetylcholine; Aging; Animals; Aorta; Cyclooxygenase 1; Cyclooxygenase 2; Endothelium, Vascular; Gly	2015
Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects. Scientific reports, 2015, May-22, Volume: 5 Topics: Acyltransferases; Aged, 80 and over; Aging; Cell Differentiation; Cell Line; Cellular Reprogramming;	2015
[EFFECT OF PROPARGYLGLYCINE UPON CARDIOHEMODYNAMICS IN OLD RATS]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2015, Volume: 61, Issue:4 Topics: Adenosine Triphosphate; Aging; Alkynes; Animals; Blood Pressure; Diastole; Glycine; Heart Atria; Hyd	2015
Treatment by glyphosate-based herbicide alters life history parameters of the rose-grain aphid Metopolophium dirhodum. Scientific reports, 2016, 06-15, Volume: 6 Topics: Aging; Animals; Aphids; Female; Fertility; Glycine; Glyphosate; Herbicides; Life Cycle Stages; Repro	2016
Liver function declines with increased age. HPB : the official journal of the International Hepato Pancreato Biliary Association, 2016, Volume: 18, Issue:8 Topics: Adolescent; Adult; Age Factors; Aged; Aging; Aniline Compounds; Body Surface Area; Carcinoma, Hepato	2016
Activation of group I metabotropic glutamate receptors induces long-term depression in the hippocampal CA1 region of adult rats in vitro. Neuroscience research, 2008, Volume: 62, Issue:1 Topics: Age Factors; Aging; Animals; Axons; Benzoates; Electric Stimulation; Excitatory Amino Acid Antagonis	2008
Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia. Neurochemical research, 2009, Volume: 34, Issue:9 Topics: Aging; Alanine; Animals; Aspartic Acid; Brain Ischemia; Brain Stem; Female; gamma-Aminobutyric Acid;	2009
Effects of inhibitory amino acids on adenosine release in the mouse hippocampus. Proceedings of the Western Pharmacology Society, 2008, Volume: 51 Topics: Adenosine; Aging; Animals; Animals, Newborn; beta-Alanine; Excitatory Amino Acid Antagonists; Female	2008
Oxytocin and vasopressin enhance synaptic transmission in the hypoglossal motor nucleus of young rats by acting on distinct receptor types. Neuroscience, 2010, Feb-03, Volume: 165, Issue:3 Topics: Aging; Animals; Animals, Newborn; Axons; Cell Membrane; Dendrites; Excitatory Postsynaptic Potential	2010
Effects of glyoxal or methylglyoxal on the metabolism of amino acids, lactate, glucose and acetate in the cerebral cortex of young and adult rats. Brain research, 2010, Feb-22, Volume: 1315 Topics: Acetates; Aging; Amino Acids; Animals; Carbon Dioxide; Central Nervous System Agents; Cerebral Corte	2010
Plasticity of synaptic inhibition in mouse spinal cord lamina II neurons during early postnatal development and after inactivation of the glycine receptor alpha3 subunit gene. The European journal of neuroscience, 2009, Volume: 30, Issue:12 Topics: Aging; Animals; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Inhibitory Postsynaptic Poten	2009
Glycine-creatine metabolism in its relationship to aging. Journal of gerontology, 1947, Volume: 2, Issue:4 Topics: Age Factors; Aging; Creatine; Glycine; Humans	1947
Direct and indirect control of orexin/hypocretin neurons by glycine receptors. The Journal of physiology, 2011, Feb-01, Volume: 589, Issue:Pt 3 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Alanine; Animals; Animals, Newborn; Benzothiadiazines;	2011
Excitatory-inhibitory imbalance in hypoglossal neurons during the critical period of postnatal development in the rat. The Journal of physiology, 2011, Apr-15, Volume: 589, Issue:Pt 8 Topics: Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain Stem; Electric Stimulatio	2011
Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiology of aging, 2012, Volume: 33, Issue:9 Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Bicu	2012
Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice. Anesthesiology, 2012, Volume: 117, Issue:4 Topics: Aging; Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Electrophysiological Phen	2012
Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. Aging cell, 2012, Volume: 11, Issue:6 Topics: Aging; Amino Acid Motifs; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Behavior	2012
Dietary guanidino acetic acid is an efficacious replacement for arginine for young chicks. Poultry science, 2013, Volume: 92, Issue:1 Topics: Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Arginine; Chickens; Diet; G	2013
Hippocampal Gαq/₁₁ but not Gαo-coupled receptors are altered in aging. Neuropharmacology, 2013, Volume: 70 Topics: Aging; Animals; Baclofen; CA1 Region, Hippocampal; Calcium; Excitatory Amino Acid Agonists; GABA-B R	2013
Characterization of GABA(A) and glycine receptors in neurons of the developing rat inferior colliculus. Pflugers Archiv : European journal of physiology, 2002, Volume: 445, Issue:2 Topics: Aging; Animals; Animals, Newborn; Electric Conductivity; gamma-Aminobutyric Acid; Glycine; In Vitro	2002
Elimination and strengthening of glycinergic/GABAergic connections during tonotopic map formation. Nature neuroscience, 2003, Volume: 6, Issue:3 Topics: Aging; Animals; Animals, Newborn; Auditory Pathways; Brain Mapping; Cluster Analysis; gamma-Aminobut	2003
Expression and function of chloride transporters during development of inhibitory neurotransmission in the auditory brainstem. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, May-15, Volume: 23, Issue:10 Topics: Aging; Animals; Brain Stem; Cochlear Nerve; Evoked Potentials, Auditory, Brain Stem; gamma-Aminobuty	2003
[Variations of the turnover of elastin of the aorta in aging of the white rat studied with C-14 glycine]. Giornale di gerontologia, 1960, Volume: 8 Topics: Aging; Animals; Aorta; Elastin; Glycine; Proteins; Rats; Research	1960
Influence of age on glycine and purine metabolism. Archives of biochemistry and biophysics, 1962, Volume: 99 Topics: Adenine; Aging; Biochemical Phenomena; Glycine; Metabolic Networks and Pathways; Purines; RNA	1962
[BEHAVIOR OF THE COMPONENTS OF THE CONNECTIVE TISSUE OF THE WALL OF THE AORTA AND CORONARY ARTERIES IN VARIOUS AGES]. Polskie Archiwum Medycyny Wewnetrznej, 1963, Volume: 33 Topics: Adolescent; Aging; Aorta; Calcium; Child; Collagen; Connective Tissue; Coronary Vessels; Geriatrics;	1963
TRANSPORT AND INCORPORATION OF AMINO ACIDS INTO THE AORTIC WALL: INFLUENCE OF AGE AND HORMONES. Angiologica, 1964, Volume: 1 Topics: Aging; Alanine; Amino Acids; Aminobutyrates; Animals; Aorta; Carbon Isotopes; Diabetes Mellitus, Exp	1964
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG. III. SPINAL CORD. Journal of neurochemistry, 1964, Volume: 11 Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Cystine; Fetus; Glutamates;	1964
AN AUTORADIOGRAPHIC EVALUATION OF THE AGING CELLULAR PHASE OF MOUSE SKELETON USING TRITIATED GLYCINE. Journal of gerontology, 1964, Volume: 19 Topics: Aging; Animals; Autoradiography; Bone and Bones; Epiphyses; Femur; Glycine; Mice; Periosteum; Resear	1964
STUDIES ON THE PROTEIN SYNTHESIS IN SILKGLANDS. V. THE RELATION OF RIBOSOMES TO ENDOPLASMIC RETICULUM DURING FIBROIN SYNTHESIS. Journal of biochemistry, 1964, Volume: 55 Topics: Aging; Amino Acids; Animals; Bombyx; Carbon Isotopes; Centrifugation; Chemistry Techniques, Analytic	1964
THE DEVELOPMENT OF THE HIPPURIC ACID-SYNTHESIZING SYSTEM IN THE RAT. Developmental biology, 1964, Volume: 10 Topics: 4-Aminobenzoic Acid; Adrenalectomy; Aging; Animals; Animals, Newborn; Female; Fetus; Glycine; Hippur	1964
[BLOOD CHOLESTEROL AND TRIGLYCERIDES IN 2 OCCUPATIONAL GROUPS. FIRST RESULTS OF AN EPIDEMIOLOGIC INVESTIGATION ON THE FACTORS OF ATHEROSCLEROSIS]. Revue de l'atherosclerose, 1964, Volume: 6 Topics: Adolescent; Aging; Arteriosclerosis; Atherosclerosis; Blood; Blood Pressure; Body Weight; Cholestero	1964
THE EFFECT OF AGING ON PROTEIN SYNTHESIS IN ARTICULAR CARTILAGE OF RABBITS. Laboratory investigation; a journal of technical methods and pathology, 1965, Volume: 14 Topics: Aging; Animals; Cartilage; Cartilage, Articular; Cell Biology; DNA; Glycine; Proteins; Rabbits; Rese	1965
EFFECT OF "NON-SPECIFIC" NITROGEN INTAKE ON ADEQUACY OF CEREAL PROTEINS FOR NITROGEN RETENTION IN HUMAN ADULTS. The Journal of nutrition, 1965, Volume: 86, Issue:4 Topics: Adult; Aging; Amino Acids; Ammonium Compounds; Body Height; Body Weight; Citrates; Dietary Proteins;	1965
CONNECTIVE TISSUE. IX. METABOLISM OF COLLAGEN IN BONE OF RAT. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 119 Topics: Aging; Bone and Bones; Carbon Isotopes; Collagen; Connective Tissue; Glycine; Metabolism; Rats; Rese	1965
The serotonin precursor 5-hydroxytryptophan delays neuromuscular disease in murine familial amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2003, Volume: 4, Issue:3 Topics: 5-Hydroxytryptophan; Aging; Alanine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Body	2003
Age-dependent changes in the lateral superior olive of the gerbil (Meriones unguiculatus). Hearing research, 2004, Volume: 194, Issue:1-2 Topics: Aging; Animals; Auditory Pathways; Cell Count; gamma-Aminobutyric Acid; Gerbillinae; Glycine; Humans	2004
Bi-directional plasticity and age-dependent long-term depression at mouse CA3-CA1 hippocampal synapses. Neuroscience letters, 2004, Aug-26, Volume: 367, Issue:1 Topics: Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Dose-Response Relationship, Dru	2004
Effects of undernutrition on glycine metabolism in the cerebellum of rats. Annals of nutrition & metabolism, 2004, Volume: 48, Issue:4 Topics: Aging; Animals; Carbon Radioisotopes; Cerebellum; Dietary Proteins; Female; Glycine; Litter Size; Me	2004
The effects of age and hyperhomocysteinemia on the redox forms of plasma thiols. The Journal of laboratory and clinical medicine, 2004, Volume: 144, Issue:5 Topics: Adolescent; Adult; Aged; Aging; Arteriosclerosis; Blood Proteins; Cardiovascular Diseases; Child; Ch	2004
Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats. Biochemical and biophysical research communications, 2005, Feb-18, Volume: 327, Issue:3 Topics: Acetylcholine; Aging; Animals; Aspartic Acid; Choline; Dentate Gyrus; Glutamic Acid; Glycine; Hydrox	2005
Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis. Free radical biology & medicine, 2005, Mar-01, Volume: 38, Issue:5 Topics: Aging; Alkynes; Animals; Cataract; Cystathionine gamma-Lyase; Glutathione; Glycine; Lens, Crystallin	2005
Age-related changes in the inhibitory response properties of dorsal cochlear nucleus output neurons: role of inhibitory inputs. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Nov-23, Volume: 25, Issue:47 Topics: Acoustic Stimulation; Aging; Animals; Cell Count; Cochlea; Cochlear Nucleus; Differential Threshold;	2005
Shift from depolarizing to hyperpolarizing glycine action occurs at different perinatal ages in superior olivary complex nuclei. The European journal of neuroscience, 2005, Volume: 22, Issue:11 Topics: Aging; Animals; Animals, Newborn; Basal Ganglia; Chloride Channels; Coloring Agents; Data Interpreta	2005
Immunocytochemical analysis of D-serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neurons. Glia, 2006, Volume: 53, Issue:4 Topics: Aging; Animals; Biomarkers; Brain; Brain Chemistry; Fixatives; Formaldehyde; gamma-Aminobutyric Acid	2006
Substantia Gelatinosa neurons in defined-medium organotypic slice culture are similar to those in acute slices from young adult rats. Pain, 2006, Volume: 121, Issue:3 Topics: Action Potentials; Afferent Pathways; Aging; Animals; Chronic Disease; Culture Media; Electric Stimu	2006
Methods for the diagnosis of creatine deficiency syndromes: a comparative study. Journal of neuroscience methods, 2006, Sep-30, Volume: 156, Issue:1-2 Topics: Adolescent; Aging; Biomarkers; Child; Child, Preschool; Chromatography, High Pressure Liquid; Creati	2006
Pharmacological properties of glycine uptake in the developing rat retina. Neurochemistry international, 2006, Volume: 49, Issue:4 Topics: Aging; Amino Acids; Amoxapine; Animals; Biological Transport, Active; Fluorescent Dyes; Glycine; Gly	2006
Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia. Neuroscience letters, 2006, Jul-10, Volume: 402, Issue:1-2 Topics: Aged, 80 and over; Aging; Dementia; DNA Mutational Analysis; Female; Glycine; Humans; Jews; Leucine-	2006
Age-related effects of the neuromodulator D-serine on neurotransmission and synaptic potentiation in the CA1 hippocampal area of the rat. Journal of neurochemistry, 2006, Volume: 98, Issue:4 Topics: Aging; Animals; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Glycine; Hippoca	2006
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America, 2006, Oct-24, Volume: 103, Issue:43 Topics: Aging; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Bone Marrow Cells; Bone Marrow Tran	2006
Guanidinoacetate inhibits glutamate uptake in rat striatum of rats at different ages. Neurochemical research, 2007, Volume: 32, Issue:6 Topics: Aging; Animals; Glutamic Acid; Glycine; Microinjections; Neostriatum; Nerve Tissue Proteins; Rats; R	2007
[Hutchinson-Gilford progeria syndrome: clinical and molecular analysis in an African patient]. Revue medicale de Liege, 2007, Volume: 62, Issue:3 Topics: Africa; Aging; Child; Chromatography, Liquid; Exons; Female; Glycine; Humans; Lamin Type A; Mutation	2007
Serum pro-hepcidin levels and relationship with ferritin in healthy non-anaemic infants. Acta haematologica, 2007, Volume: 118, Issue:2 Topics: Age Factors; Aging; Antimicrobial Cationic Peptides; Biomarkers; Dietary Supplements; Female; Ferrit	2007
[Effect of deltaran on the mediatory balance in the brain of young and old rats with left-side laterality profile in case of carotid arteries occlusion]. Advances in gerontology = Uspekhi gerontologii, 2007, Volume: 20, Issue:2 Topics: Aging; Animals; Arterial Occlusive Diseases; Brain; Brain Ischemia; Carotid Arteries; Delta Sleep-In	2007
[Protein synthesis and the regulation process in the cell]. Arkhiv anatomii, gistologii i embriologii, 1966, Volume: 50, Issue:5 Topics: Aging; Animals; Arginine; Autoradiography; Axons; Body Weight; Cell Biology; Cytoplasmic Granules; G	1966
The effect of hyperphenylalaninaemia on glycine metabolism in developing rat brain. The Biochemical journal, 1980, Nov-15, Volume: 192, Issue:2 Topics: Aging; Amino Acids; Animals; Brain; Glycine; Neurotransmitter Agents; Phenylalanine; Rats; Serotonin	1980
Developmental changes in amino acid transport in the chicken erythrocyte. Comparative biochemistry and physiology. A, Comparative physiology, 1983, Volume: 74, Issue:4 Topics: Aging; Amino Acids; Animals; Chickens; Erythrocytes; Glycine; Kinetics; Leucine; Lysine	1983
Postnatal development of synaptic glycine receptors in normal and hyperglycinemic rats. Journal of neurochemistry, 1981, Volume: 37, Issue:2 Topics: Aging; Animals; Animals, Newborn; Brain; Glycine; Kinetics; Receptors, Cell Surface; Receptors, Glyc	1981
Glycine-directed peptide amidation: presence in rat brain of two enzymes that convert p-Glu-His-Pro-Gly-OH into p-Glu-His-Pro-NH2 (thyrotropin-releasing hormone). Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:10 Topics: Aging; Animals; Animals, Newborn; Brain; Glycine; Kinetics; Mass Spectrometry; Pituitary Gland; Prot	1984
Improvement of nitrogen retention by arginine and glycine supplementation and its relation to collagen synthesis in traumatized mature and aged rats. The Journal of nutrition, 1984, Volume: 114, Issue:9 Topics: Aging; Animals; Arginine; Collagen; Food, Fortified; Glycine; Hydroxyproline; Male; Nitrogen; Rats;	1984
Erythroid colony development as a function of age: the role of marrow cellular heme. Journal of gerontology, 1983, Volume: 38, Issue:1 Topics: 5-Aminolevulinate Synthetase; Aging; Animals; Erythrocytes; Erythropoiesis; Glycine; Hematopoietic S	1983
Higher excretion of urinary bound amino acids in infants: probably related to protein-anabolic effect of growth hormone. The Tohoku journal of experimental medicine, 1982, Volume: 137, Issue:1 Topics: Aging; Alanine; Amino Acids; Arginine; Child; Child, Preschool; Cystine; Cystinuria; Glycine; Growth	1982
Glutathione biosynthesis in the aging adult yellow-fever mosquito [Aedes aegypti (Louisville)]. The Biochemical journal, 1983, Feb-15, Volume: 210, Issue:2 Topics: Aedes; Aging; Amino Acids; Animals; Cystine; Female; Glutathione; Glycine; Kinetics; Time Factors	1983
Altered biosynthesis in retinal degeneration. Methods in enzymology, 1982, Volume: 81 Topics: Aging; Animals; Carbon Radioisotopes; Dogs; Glycine; Mice; Radioisotope Dilution Technique; Rats; Ra	1982
Development of dipeptide transport in the intestinal mucosa of rabbits. Pediatric research, 1982, Volume: 16, Issue:2 Topics: Aging; Amino Acids; Animals; Dipeptides; Fetus; Glycine; In Vitro Techniques; Intestinal Absorption;	1982
Developmental changes of glycine transport in the dog. Biochimica et biophysica acta, 1982, Dec-08, Volume: 693, Issue:1 Topics: Aging; Animals; Animals, Newborn; Biological Transport; Dogs; Female; Glycine; Kidney; Kidney Cortex	1982
Long-term follow-up of incorporation of 15N from glycine into uric acid in gout. The American journal of medicine, 1981, Volume: 70, Issue:4 Topics: Adult; Aged; Aging; Follow-Up Studies; Glycine; Gout; Humans; Male; Middle Aged; Nitrogen; Nitrogen	1981
[Assessment of the protein requirement in old age (author's transl)]. Zeitschrift fur Alternsforschung, 1981, Volume: 36, Issue:5 Topics: Aging; Animals; Blood Proteins; Dietary Proteins; Glycine; Glycogen; Lipid Metabolism; Nutritional R	1981
Glycine and benzoate conjugation and glycine acyltransferase activity in the developing and adult rat: possible relationships to nonketotic hyperglycinemia. Developmental pharmacology and therapeutics, 1981, Volume: 3, Issue:3 Topics: Acyltransferases; Adult; Aging; Amino Acid Metabolism, Inborn Errors; Animals; Benzoates; Brain; Chi	1981
Experimental hyperphenylalaninemia: effect on central nervous system myelin subfractions. Experimental neurology, 1980, Volume: 67, Issue:2 Topics: Aging; Brain; Glucose; Glycine; Myelin Proteins; Myelin Sheath; Nerve Tissue Proteins; Phenylalanine	1980
Age-dependent change in intestinal absorption of dipeptides and their constituent amino acids in the guinea pig. Pediatric research, 1980, Volume: 14, Issue:11 Topics: Aging; Amino Acids; Animals; Animals, Newborn; Dipeptides; Glycine; Glycylglycine; Guinea Pigs; Ileu	1980
Development of glycinergic and glutamatergic synaptic transmission in the auditory brainstem of perinatal rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:10 Topics: Aging; Animals; Auditory Pathways; Brain Stem; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glyci	1995
Developmental changes of free amino acid concentrations in fetal fluids of pigs. The Journal of nutrition, 1995, Volume: 125, Issue:11 Topics: Aging; Allantois; Amino Acids; Ammonia; Amniotic Fluid; Animals; Arginine; Female; Fetal Blood; Gest	1995
Glycine release from hippocampal slices in developing and ageing mice: modulation by glutamatergic receptors. Mechanisms of ageing and development, 1994, Oct-20, Volume: 76, Issue:2-3 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci	1994
Glycine- and GABA-activated currents in identified glial cells of the developing rat spinal cord slice. The European journal of neuroscience, 1995, Jun-01, Volume: 7, Issue:6 Topics: Aging; Animals; Animals, Newborn; Astrocytes; Chlorides; Electrophysiology; gamma-Aminobutyric Acid;	1995
Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS. The European journal of neuroscience, 1995, Jun-01, Volume: 7, Issue:6 Topics: Aging; Amino Acid Transport Systems, Neutral; Animals; Animals, Newborn; Base Sequence; Blotting, No	1995
Age-dependent neurotoxicity of striatal lesions produced by aminooxyacetic acid: quantitative in vitro 1H NMR spectroscopic studies. Journal of neurochemistry, 1995, Volume: 65, Issue:3 Topics: Aging; Alanine; Animals; Aspartic Acid; Corpus Striatum; Creatine; Energy Metabolism; gamma-Aminobut	1995
Age-related reduction of [3H]strychnine binding sites in the cochlear nucleus of the Fischer 344 rat. Neuroscience, 1995, Volume: 67, Issue:3 Topics: Age Factors; Aging; Animals; Autoradiography; Binding Sites; Cochlear Nucleus; Glycine; Rats; Rats,	1995
K(+)- and transmitter-induced rises in [Ca2+]i in auditory neurones of developing rats. Neuroreport, 1994, Nov-21, Volume: 5, Issue:17 Topics: Aging; Animals; Animals, Newborn; Auditory Pathways; Calcium; Fura-2; Glutamic Acid; Glycine; Intrac	1994
A cellular stress model for the sequestration of redox-active glial iron in the aging and degenerating nervous system. Journal of neurochemistry, 1995, Volume: 64, Issue:4 Topics: Aging; Aminolevulinic Acid; Animals; Astrocytes; Cysteamine; Glycine; Heme; Heme Oxygenase (Decycliz	1995
NMDA receptor function is enhanced in the hippocampus of aged rats. Neurochemical research, 1994, Volume: 19, Issue:4 Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate;	1994
Developmental changes in the effects of metabotropic glutamate receptor antagonists on CA1 long-term potentiation in rat hippocampal slices. Neuroscience letters, 1994, Jul-18, Volume: 176, Issue:1 Topics: Aging; Alanine; Aminobutyrates; Animals; Benzoates; Glycine; Hippocampus; In Vitro Techniques; Long-	1994
3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus. Journal of neurochemistry, 1994, Volume: 63, Issue:2 Topics: Aging; Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Colforsin; Cyclic AMP; Cycloleucine; Do	1994
Regulation of D-aspartate release by glutamate and GABA receptors in cerebral cortical slices from developing and ageing mice. Neuroscience, 1994, Volume: 60, Issue:1 Topics: Aging; Animals; Aspartic Acid; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Femal	1994
Postnatal changes in N-methyl-D-aspartate receptor binding and stimulation by glutamate and glycine of [3H]-MK-801 binding in human temporal cortex. British journal of pharmacology, 1993, Volume: 108, Issue:4 Topics: Adult; Aging; Cerebral Cortex; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Glycine; Huma	1993
Strychnine-insensitive glycine binding to cerebral cortical membranes in developing and ageing mice. Mechanisms of ageing and development, 1993, Volume: 72, Issue:1 Topics: Aging; Animals; Animals, Newborn; beta-Alanine; Cerebral Cortex; Female; Glycine; Humans; Male; Memb	1993
Conjugation of benzoic acid with glycine in human liver and kidney: a study on the interindividual variability. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Aging; Benzoates; Benzoic Acid; Female; Glycine; Hippurates; Humans;	1993
Phencyclidine-binding sites in mouse cerebral cortex during development and ageing: effects of inhibitory amino acids. Mechanisms of ageing and development, 1993, Volume: 68, Issue:1-3 Topics: Aging; Animals; beta-Alanine; Cerebral Cortex; Female; Glycine; Male; Mice; Mice, Inbred Strains; Ra	1993
Protein and glucose fuel kinetics and hormonal changes in elderly trauma patients. Metabolism: clinical and experimental, 1993, Volume: 42, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Ammonia; C-Peptide; Calorimetry, Indirect; Carbon	1993
Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging. Journal of neurochemistry, 1993, Volume: 60, Issue:2 Topics: Aging; Animals; Brain; Glycine; Kidney; Liver; Male; Organ Specificity; Rats; Rats, Wistar; Receptor	1993
The development-associated increase in the hepatic levels of the intrinsic components of the chicken glycine cleavage system. Archives of biochemistry and biophysics, 1993, Volume: 300, Issue:1 Topics: Aging; Amino Acid Oxidoreductases; Aminomethyltransferase; Animals; Carrier Proteins; Chick Embryo;	1993
Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine. European journal of pharmacology, 1993, Jan-26, Volume: 231, Issue:1 Topics: Aging; Animals; Cycloserine; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nor	1993
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proceedings of the National Academy of Sciences of the United States of America, 1996, Apr-02, Volume: 93, Issue:7 Topics: Aging; Alanine; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Animals; Cytoskeleton; Glycine;	1996
Glycine enhances binding to the NMDA receptor complex in aged mice, but does not correct the aging change. The journals of gerontology. Series A, Biological sciences and medical sciences, 1996, Volume: 51, Issue:2 Topics: Aging; Animals; Glutamine; Glycine; In Vitro Techniques; Mice; Mice, Inbred Strains; Receptors, N-Me	1996
Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats. Journal of neural transmission. Parkinson's disease and dementia section, 1995, Volume: 10, Issue:1 Topics: Aging; Animals; Binding Sites; Cerebral Cortex; Dizocilpine Maleate; Dopamine Agents; Glycine; Male;	1995
Effects of aging on the microclimate pH of the rat jejunum. Biochimica et biophysica acta, 1996, Apr-03, Volume: 1280, Issue:1 Topics: Aging; Alanine; Amiloride; Animals; Bucladesine; Cell Membrane; Dibutyryl Cyclic GMP; Dipeptides; Di	1996
Phenotypic expressions of a Gly 154Arg mutation in type II collagen in two unrelated patients with spondyloepimetaphyseal dysplasia (SEMD). American journal of medical genetics, 1996, May-03, Volume: 63, Issue:1 Topics: Adult; Aging; Amino Acid Sequence; Arginine; Base Sequence; Bone and Bones; Bone Development; Collag	1996
Developmental influence of glycinergic transmission: regulation of NMDA receptor-mediated EPSPs. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Mar-01, Volume: 16, Issue:5 Topics: Aging; Animals; Animals, Newborn; Auditory Pathways; Electrophysiology; Gerbillinae; Glycine; Neural	1996
Arg506Gln factor V mutation and cerebral ischemia in the young. Stroke, 1996, Volume: 27, Issue:9 Topics: Adolescent; Adult; Aging; Arginine; Brain Ischemia; Child; Child, Preschool; Factor V; Female; Glyci	1996
Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors. Molecular pharmacology, 1996, Volume: 50, Issue:3 Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Base Sequence; Cerebral Cortex; Excit	1996
Glycine at the NMDA receptor in cat visual cortex: saturation and changes with age. Journal of neurophysiology, 1996, Volume: 75, Issue:1 Topics: Aging; Animals; Animals, Newborn; Cats; Evoked Potentials, Visual; Glycine; Iontophoresis; Neurons;	1996
Urinary excretion of 5-L-oxoproline (pyroglutamic acid) is increased during recovery from severe childhood malnutrition and responds to supplemental glycine. The Journal of nutrition, 1996, Volume: 126, Issue:11 Topics: Aging; Body Weight; Child, Preschool; Female; Food, Fortified; Glutathione; Glycine; Growth; Humans;	1996
The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors. Neuropharmacology, 1996, Volume: 35, Issue:12 Topics: Aging; Animals; Animals, Newborn; Brain; Cloning, Molecular; Colforsin; Cyclic AMP; Cycloleucine; Dr	1996
Bile acid concentrations in serum and duodenal aspirates of healthy preterm infants: effects of gestational and postnatal age. Biology of the neonate, 1997, Volume: 71, Issue:4 Topics: Aging; Bile Acids and Salts; Chenodeoxycholic Acid; Cholic Acid; Cholic Acids; Chromatography, Thin	1997
Development of inhibitory synaptic currents in rat spinal neurons. Annals of the New York Academy of Sciences, 1993, Dec-20, Volume: 707 Topics: Aging; Animals; Animals, Newborn; Embryo, Mammalian; Glycine; Neurons; Rats; Receptors, Glycine; Spi	1993
Effects of vinconate on age-related alterations in [3H]MK-801, [3H]glycine, sodium-dependent D-[3H]aspartate, [3H]FK-506 and [3H]PN200-110 binding in rats. Mechanisms of ageing and development, 1997, Volume: 95, Issue:1-2 Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Calcium Channels; Carrier Proteins; Dizocilpi	1997
Effects of chronic treatment with a cyclic AMP-selective phosphodiesterase inhibitor, rolipram, on excitatory amino acid neurotransmission systems in young and aged rat brains. Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:2-3 Topics: Aging; Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; Dizocilpine Maleate; Excitat	1997
Lysine deficiency in postweaned calves fed corn and corn gluten meal diets. Journal of animal science, 1997, Volume: 75, Issue:7 Topics: Aging; Analysis of Variance; Animals; Arginine; Caseins; Cattle; Cattle Diseases; Cysteine; Deficien	1997
The effect of an increase of protein intake on whole-body protein turnover in elderly women is tracer dependent. The Journal of nutrition, 1997, Volume: 127, Issue:9 Topics: Aged; Aging; Carbon Isotopes; Dietary Proteins; Fasting; Female; Glycine; Humans; Leucine; Nitrogen	1997
Glycine immunoreactivity and receptor binding in the cochlear nucleus of C57BL/6J and CBA/CaJ mice: effects of cochlear impairment and aging. The Journal of comparative neurology, 1997, Sep-01, Volume: 385, Issue:3 Topics: Aging; Animals; Cochlear Diseases; Cochlear Nucleus; Female; Glycine; Hearing Disorders; Immunohisto	1997
Whole-body protein turnover in the healthy elderly. The American journal of clinical nutrition, 1997, Volume: 66, Issue:4 Topics: Adult; Age Factors; Aged; Aging; Anthropometry; Body Composition; Cohort Studies; Diet; Electric Imp	1997
Is activation of the metabotropic glutamate receptors impaired in the hippocampal CA1 area of the aged rat? Hippocampus, 1997, Volume: 7, Issue:5 Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Benzoates; Cycloleucine; Excitatory Amino Acid Agonists	1997
Neurochemical development of the degenerating rat retina. The Journal of comparative neurology, 1997, Nov-10, Volume: 388, Issue:1 Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; gamma-Aminobutyric Acid; Glu	1997
Age- and dose-dependent facilitation of associative eyeblink conditioning by D-cycloserine in rabbits. Behavioral neuroscience, 1997, Volume: 111, Issue:6 Topics: Age Factors; Aging; Animals; Association Learning; Auditory Perception; Conditioning, Eyelid; Cyclos	1997
Glycine-activated currents are changed by coincident membrane depolarization in developing rat auditory brainstem neurones. The Journal of physiology, 1998, Mar-15, Volume: 507 ( Pt 3) Topics: Aging; Animals; Animals, Newborn; Auditory Pathways; Bicarbonates; Calcium; Chlorides; Evoked Potent	1998
Age-dependent and cell class-specific modulation of retinal ganglion cell bursting activity by GABA. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, May-15, Volume: 18, Issue:10 Topics: Aging; Animals; Animals, Newborn; Bicuculline; Electrophysiology; Female; Ferrets; GABA Antagonists;	1998
[Studies on changes in trace elements of the brain related to aging]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1998, Volume: 73, Issue:2 Topics: Aging; Animals; Brain; Glutamic Acid; Glycine; Humans; Learning Disabilities; Male; Memory Disorders	1998
A developmental shift from GABAergic to glycinergic transmission in the central auditory system. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jun-15, Volume: 18, Issue:12 Topics: Aging; Animals; Auditory Pathways; Baclofen; Brain; Electric Conductivity; GABA Agonists; gamma-Amin	1998
Progression of change in NMDA, non-NMDA, and metabotropic glutamate receptor function at the developing corticothalamic synapse. Journal of neurophysiology, 1998, Volume: 80, Issue:1 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn;	1998
Age-induced increase of leucine enkephalin enzyme degradation in human plasma. Peptides, 1998, Volume: 19, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Aging; Aminopeptidases; Analysis of Variance; Chromatography, Gel; C	1998
The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacology, 1998, Volume: 37, Issue:12 Topics: Aging; Amino Acids; Animals; Binding, Competitive; Cell Line; CHO Cells; Cloning, Molecular; Criceti	1998
Effect of intravenous glutamine on duodenal mucosa protein synthesis in healthy growing dogs. The American journal of physiology, 1999, Volume: 276, Issue:4 Topics: Aging; Amino Acids; Animals; Animals, Newborn; Carbon Isotopes; Dogs; Duodenum; Glutamine; Glycine;	1999
Low expression of the ClC-2 chloride channel during postnatal development: a mechanism for the paradoxical depolarizing action of GABA and glycine in the hippocampus. Proceedings. Biological sciences, 1999, Jun-22, Volume: 266, Issue:1425 Topics: Aging; Amino Acid Sequence; Animals; Animals, Newborn; Chloride Channels; Cloning, Molecular; Female	1999
Levels of amino acid neurotransmitters during mouse cerebellar neurogenesis and in histotypic cerebellar cultures. Developmental neuroscience, 1999, Volume: 21, Issue:2 Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Chromatography, High P	1999
Subpopulations of GABAergic and non-GABAergic rat dorsal horn neurons express Ca2+-permeable AMPA receptors. The European journal of neuroscience, 1999, Volume: 11, Issue:8 Topics: Aging; Animals; Calcium; Calcium-Binding Proteins; Cobalt; gamma-Aminobutyric Acid; Glycine; Immunoh	1999
Increased glutathione levels in neurochemically identified fibre systems in the aged rat lumbar motor nuclei. The European journal of neuroscience, 1999, Volume: 11, Issue:8 Topics: Aging; Animals; Axons; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Glycine; Immunohistochem	1999
Repeated seizure-associated long-lasting changes of N-methyl-D-aspartate receptor properties in the developing rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1999, Volume: 17, Issue:4 Topics: Aging; Animals; Animals, Newborn; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Excitato	1999
Shift from depolarizing to hyperpolarizing glycine action in rat auditory neurones is due to age-dependent Cl- regulation. The Journal of physiology, 1999, Oct-01, Volume: 520 Pt 1 Topics: Aging; Animals; Animals, Newborn; Chloride Channels; Diuretics; Electrophysiology; Evoked Potentials	1999
Where does indolylacrylic acid come from? Amino acids, 1999, Volume: 17, Issue:4 Topics: Aging; Burns; Diet; Glycine; Humans; Indoles; Muscular Dystrophies; Skin Diseases; Tryptophan; Urina	1999
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proceedings of the National Academy of Sciences of the United States of America, 2000, Apr-25, Volume: 97, Issue:9 Topics: Aging; Animals; Astrocytes; Cells, Cultured; Cerebellum; D-Amino-Acid Oxidase; Embryo, Mammalian; Gl	2000
Age-related decline in the functional response of striatal group I mGlu receptors. Neuroreport, 2000, Sep-11, Volume: 11, Issue:13 Topics: Aging; Animals; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glyci	2000
Involvement of metabotropic glutamate receptors in ischemia-induced taurine release in the developing and adult hippocampus. Neurochemical research, 2000, Volume: 25, Issue:8 Topics: Aging; Animals; Brain Ischemia; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Excitat	2000
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats. Brain research, 2000, Nov-24, Volume: 884, Issue:1--2 Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex	2000
Glutamate inhibition of NMDA-induced hydroxyl radical release: an ontogenic study in rat. Neuroreport, 2001, Jul-03, Volume: 12, Issue:9 Topics: Aging; Animals; Animals, Newborn; Brain; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antag	2001
A critical role of the strychnine-sensitive glycinergic system in spontaneous retinal waves of the developing rabbit. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jul-15, Volume: 21, Issue:14 Topics: Aging; Animals; Calcium; Carrier Proteins; Fluorescent Dyes; GABA Antagonists; gamma-Aminobutyric Ac	2001
Expression and function of glycine receptors in striatal cholinergic interneurons from rat and mouse. Neuroscience, 2001, Volume: 104, Issue:4 Topics: Acetylcholine; Aging; Animals; Cell Size; Chloride Channels; Dose-Response Relationship, Drug; Gene	2001
Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse. Neurochemical research, 2001, Volume: 26, Issue:7 Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo	2001
Region-specific developmental specialization of GABA-glycine cosynapses in laminas I-II of the rat spinal dorsal horn. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Oct-15, Volume: 21, Issue:20 Topics: Action Potentials; Aging; Animals; Calcium Channel Blockers; Calcium Channels; GABA Modulators; gamm	2001
The nonuniform distribution of the GABA(A) receptor alpha 1 subunit influences inhibitory synaptic transmission to motoneurons within a motor nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Nov-01, Volume: 21, Issue:21 Topics: Aging; Animals; Animals, Newborn; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glycin	2001
Ethanol inhibition of glycine-activated responses in neurons of ventral tegmental area of neonatal rats. Journal of neurophysiology, 2001, Volume: 86, Issue:5 Topics: Aging; Animals; Animals, Newborn; Drug Contamination; Electric Conductivity; Ethanol; Glycine; Kinet	2001
Metabotropic glutamate receptors stimulate phospholipase D via different pathways in the adult and neonate rat hippocampus. Neurochemical research, 2001, Volume: 26, Issue:10 Topics: Aging; Animals; Animals, Newborn; Cycloleucine; Cyclopropanes; Glycine; Hippocampus; Kinetics; Metho	2001
Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:5 Topics: Aging; Carotid Arteries; Cohort Studies; Compliance; Elastin; Female; Genotype; Glycine; Humans; Mal	2001
Long-term effect of partial nephrectomy on biological parameters, kidney histology, and guanidino compound levels in mice. Metabolism: clinical and experimental, 2001, Volume: 50, Issue:12 Topics: Aging; Animals; Arginine; Brain Chemistry; Creatinine; Glycine; Guanidines; Homoarginine; Humans; Hy	2001
Differential susceptibility to ageing of rat preganglionic neurones projecting to the major pelvic ganglion and of their afferent inputs. Autonomic neuroscience : basic & clinical, 2002, Feb-28, Volume: 96, Issue:1 Topics: Afferent Pathways; Aging; Animals; Dendrites; Disease Susceptibility; Efferent Pathways; gamma-Amino	2002
Age dependent changes in the medial nucleus of the trapezoid body in gerbils. Hearing research, 2002, Volume: 164, Issue:1-2 Topics: Aging; Animals; Auditory Pathways; Cochlear Nerve; Gerbillinae; Glycine; Immunohistochemistry; Pons	2002
Differential ontogeny of GABA(B)-receptor-mediated pre- and postsynaptic modulation of GABA and glycine transmission in respiratory rhythm-generating network in mouse. The Journal of physiology, 2002, Apr-15, Volume: 540, Issue:Pt 2 Topics: Aging; Animals; Animals, Newborn; Brain Stem; Electrophysiology; Excitatory Postsynaptic Potentials;	2002
Isolation and identification of urinary beta-aspartyl dipeptides and their concentrations in human urine. Journal of biochemistry, 1978, Volume: 84, Issue:3 Topics: Adolescent; Adult; Aged; Aging; Aspartic Acid; Child; Dipeptides; Female; Glutamates; Glycine; Human	1978
The changing pattern of whole body protein metabolism in aging humans. Journal of gerontology, 1978, Volume: 33, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Body Composition; Creatinine; Female; Glycine; Hu	1978
Decreased conjugation of p-aminobenzoic acid in the icteric newborn Gunn rat. Biochemical pharmacology, 1977, Mar-15, Volume: 26, Issue:6 Topics: 4-Aminobenzoic Acid; Aging; Aminobenzoates; Animals; Animals, Newborn; Female; Genotype; Glucuronosy	1977
Free amino acids in the plasma and urine of dogs from birth to senescence. American journal of veterinary research, 1979, Volume: 40, Issue:6 Topics: Aging; Amino Acids; Animals; Animals, Newborn; Dogs; Glycine; Methylhistidines	1979
Studies on the rat glomerular basement membrane: age-related changes in composition. Archives of biochemistry and biophysics, 1978, Jan-30, Volume: 185, Issue:2 Topics: Aging; Amino Acids; Animals; Basement Membrane; Female; Glycine; Hydroxylysine; Hydroxyproline; Kidn	1978
On the development of glycine transport systems by rat renal cortex. Biochimica et biophysica acta, 1978, Aug-04, Volume: 511, Issue:2 Topics: Aging; Animals; Animals, Newborn; Biological Transport; Female; Glycine; Humans; Kidney Cortex; Kidn	1978
Fine structure of the lens epithelium. Annals of ophthalmology, 1975, Volume: 7, Issue:5 Topics: Adult; Aged; Aging; Animals; Cell Nucleus; Chick Embryo; Cytological Techniques; Endoplasmic Reticul	1975
Total human body protein synthesis in relation to protein requirements at various ages. Nature, 1975, Jan-17, Volume: 253, Issue:5488 Topics: Adult; Age Factors; Aged; Aging; Dietary Proteins; Energy Metabolism; Glycine; Humans; Infant; Infan	1975
Isolation and characterization of an age-dependent polypeptide from human lens with non-tryptophan fluorescence. Experimental eye research, 1975, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Aging; Amino Acids; Child; Child, Preschool; Chromatography, Ion Exchange;	1975
Regulatory characteristics of amino acid transport in newborn rat renal cortex cells. Biochimica et biophysica acta, 1976, Mar-19, Volume: 426, Issue:3 Topics: Aging; Amino Acids; Aminoisobutyric Acids; Anaerobiosis; Animals; Animals, Newborn; Biological Trans	1976
Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels. Neuron, 1992, Volume: 9, Issue:6 Topics: Aging; Animals; Gestational Age; Glycine; Ion Channel Gating; Ion Channels; Macromolecular Substance	1992
N-methyl-D-aspartate binding sites in neonatal and adult brain. Lancet (London, England), 1992, May-16, Volume: 339, Issue:8803 Topics: Aged; Aging; Brain; Dizocilpine Maleate; Glycine; Humans; Infant, Newborn; Receptors, N-Methyl-D-Asp	1992
The effect of glycine administration on taurine concentration in the rat liver. Comparative biochemistry and physiology. Comparative physiology, 1992, Volume: 102, Issue:1 Topics: Aging; Animals; Animals, Newborn; Glycine; Liver; Rats; Rats, Inbred Strains; Taurine	1992
Age-related alterations of NMDA-receptor properties in the mouse forebrain: partial restoration by chronic phosphatidylserine treatment. Brain research, 1992, Jul-03, Volume: 584, Issue:1-2 Topics: Aging; Animals; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques	1992
The ontogeny of the uptake systems for glutamate, GABA, and glycine in synaptic vesicles isolated from rat brain. Neurochemical research, 1992, Volume: 17, Issue:5 Topics: Adenosine Triphosphate; Aging; Animals; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; G	1992
[3H]MK-801 binding to the NMDA receptor complex, and its modulation in human frontal cortex during development and aging. Brain research, 1992, Aug-21, Volume: 588, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Child, Preschool; Dizocilpine Maleate; Fem	1992
Relationship between a long-term treatment of 2-mercaptoethanol and protein metabolism in the ageing rat. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 1992, Volume: 162, Issue:6 Topics: Aging; Animals; Female; Glycine; Kinetics; Mercaptoethanol; Methylhistidines; Nitrogen; Protein Bios	1992
[Guanidino compounds in the elderly]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1992, Volume: 29, Issue:4 Topics: Aged; Aging; Bed Rest; Cerebrovascular Disorders; Diabetes Mellitus; Female; Glycine; Humans; Kidney	1992
The effect of age on binding of MK-801 in the cat visual cortex. Brain research. Developmental brain research, 1991, Sep-19, Volume: 62, Issue:1 Topics: Aging; Animals; Cats; Darkness; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Magnesium;	1991
The ontogeny of the uptake systems for glycine, GABA and glutamate in synaptic vesicles isolated from rat spinal cord-medulla. Brain research. Developmental brain research, 1991, Dec-17, Volume: 64, Issue:1-2 Topics: Aging; Animals; Animals, Newborn; Cell Membrane; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid;	1991
N-methyl-D-aspartate and aspartate raise the cytosolic free calcium concentration by acting upon receptors transiently expressed on immature cerebellar Purkinje cells. Neuroscience letters, 1991, Oct-28, Volume: 132, Issue:1 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn;	1991
Conjugation of benzoic acid with glycine in the human fetal and adult liver and kidney. Developmental pharmacology and therapeutics, 1991, Volume: 17, Issue:1-2 Topics: Acyltransferases; Adult; Aged; Aging; Benzoates; Benzoic Acid; Culture Techniques; Female; Fetus; Gl	1991
Initial expression and endogenous activation of NMDA channels in early neocortical development. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1991, Volume: 11, Issue:3 Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Gestational Age; Glycine; Magnesium; N-Methylaspa	1991
Age-related changes of strychnine-insensitive glycine receptors in rat brain as studied by in vitro autoradiography. Synapse (New York, N.Y.), 1990, Volume: 6, Issue:4 Topics: Aging; Animals; Autoradiography; Brain; Brain Chemistry; Glycine; In Vitro Techniques; Kinetics; Mal	1990
Deferred effects of preweaning nutrition on lipid metabolism. Annals of the New York Academy of Sciences, 1991, Volume: 623 Topics: Aging; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Suckling; Bile Aci	1991
Glycine administration decreases hepatic taurine content in mice. Biochemistry international, 1990, Volume: 22, Issue:4 Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Glycine; Liver; Male; Mice; Myocardium; Taurine; Ti	1990
Postnatal development of the glycine cleavage system in rat liver. Biochemical medicine and metabolic biology, 1990, Volume: 43, Issue:2 Topics: Aging; Amino Acids; Aminomethyltransferase; Animals; Animals, Newborn; Female; Glycine; Glycine Hydr	1990
Influence of age on NMDA receptor complex in rat brain studied by in vitro autoradiography. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1990, Volume: 38, Issue:12 Topics: Aging; Animals; Autoradiography; Brain; Cerebral Cortex; Glycine; Hippocampus; Male; Piperazines; Ra	1990
The allosteric glycine site of the N-methyl-D-aspartate receptor modulates GABAergic-mediated synaptic events in neonatal rat CA3 hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:1 Topics: Aging; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Aspartic Acid; Electric Co	1990
Decreased density, but not number, of N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats. Brain research, 1990, Nov-05, Volume: 532, Issue:1-2 Topics: Aging; Animals; Glycine; Hippocampus; Male; Neuronal Plasticity; Organophosphorus Compounds; Phencyc	1990
[The effect of intravenous administration of arginine and glycine on the blood plasma content of glucose, insulin, free fatty acids and total alpha-amino-N-compounds in lambs of different ages]. Archiv fur experimentelle Veterinarmedizin, 1990, Volume: 44, Issue:3 Topics: Aging; Animals; Arginine; Blood Glucose; Fatty Acids, Nonesterified; Glycine; Insulin; Sheep	1990
Renal vasodilatory response to intravenous glycine in the aging rat kidney. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1990, Volume: 15, Issue:3 Topics: Aging; Animals; Glomerular Filtration Rate; Glycine; Kidney; Male; Rats; Rats, Inbred Strains; Renal	1990
Effects of aging and xerosis on the amino acid composition of human skin. The Journal of investigative dermatology, 1990, Volume: 95, Issue:3 Topics: Aging; Amino Acids; Female; Filaggrin Proteins; Glycine; Humans; Ichthyosis; Leucine; Phenylalanine;	1990
Discrimination of heterogenous mRNAs encoding strychnine-sensitive glycine receptors in Xenopus oocytes by antisense oligonucleotides. Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:20 Topics: Aging; Animals; Base Sequence; beta-Alanine; Female; gamma-Aminobutyric Acid; Glycine; Kainic Acid;	1989
[The effect of sodium ions on amino acid and peptide assimilation in the small intestine of developing chicks]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1989, Volume: 75, Issue:9 Topics: Aging; Amino Acids; Animals; Chickens; Dipeptides; Glycine; Intestinal Absorption; Intestinal Mucosa	1989
Age-dependent changes in brain glycine concentration and strychnine-induced seizures in the rat. Brain research, 1989, Mar-20, Volume: 482, Issue:2 Topics: Aging; Animals; Glycine; Medulla Oblongata; Rats; Rats, Inbred F344; Seizures; Spinal Cord; Strychni	1989
Glycinergic systems in the brain stem of developing and adult mice: effects of taurine. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1987, Volume: 5, Issue:5-6 Topics: Aging; Animals; Anticonvulsants; beta-Alanine; Binding, Competitive; Brain Stem; Female; Glycine; In	1987
Expression of GABA and glycine receptors by messenger RNAs from the developing rat cerebral cortex. Proceedings of the Royal Society of London. Series B, Biological sciences, 1988, Jul-22, Volume: 234, Issue:1275 Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Female; Gestational Age; Glycine; Male; Membrane	1988
Age differences in the effect of hydrocortisone on the synthesis of insoluble elastin in aortic tissue of growing chicks. Connective tissue research, 1987, Volume: 16, Issue:3 Topics: Aging; Animals; Aorta; Chick Embryo; Chickens; Elastin; Glycine; Hydrocortisone; Muscle, Smooth, Vas	1987
Folic acid responsive postmenopausal homocysteinemia. Metabolism: clinical and experimental, 1985, Volume: 34, Issue:11 Topics: Adult; Aging; Cystine; Dipeptides; Fasting; Female; Folic Acid; Glycine; Homocysteine; Humans; Male;	1985
Protein and nucleic acid synthesis in tissue fractions of rat skin. Archives internationales de physiologie et de biochimie, 1971, Volume: 79, Issue:2 Topics: Aging; Animals; Carbon Isotopes; Cells; Epithelial Cells; Epithelium; Glycine; Hair; Histocytochemis	1971
The effect of ionising radiation on the incorporation of (2- 14 C) glycine into the proteins of epiderm and derm fractions of rat skin. Archives internationales de physiologie et de biochimie, 1972, Volume: 80, Issue:3 Topics: Aging; Animals; Carbon Isotopes; Epithelial Cells; Epithelium; Glycine; Hair; Male; Microbial Collag	1972
Some properties of guinea pig brain glutamate decarboxylase and its inhibition by the convulsant allylglycine (2-amino-4-pentenoic acid). Journal of neurochemistry, 1974, Volume: 23, Issue:2 Topics: Aging; Allyl Compounds; Amino Acids; Animals; Anions; Brain; Carbon Radioisotopes; Carboxy-Lyases; C	1974
Properties of heparan sulphate and chondroitin sulphate from young and old human aortae. The Biochemical journal, 1969, Volume: 114, Issue:1 Topics: Adolescent; Adult; Aged; Aging; Amino Acids; Aorta, Thoracic; Aspartic Acid; Chondroitin; Chromatogr	1969
The effect of ageing upon collagen metabolism. Symposia of the Society for Experimental Biology, 1967, Volume: 21 Topics: Aging; Animals; Body Weight; Burns; Citrates; Collagen; Cycloheximide; Desoxycorticosterone; Glycine	1967
[Biochemical stigmas of human skin surface in old age (author's transl)]. Zeitschrift fur klinische Chemie und klinische Biochemie, 1974, Volume: 12, Issue:3 Topics: Adult; Aged; Aging; Alanine; Amino Acids; Ammonia; Citrulline; Glutamates; Glycine; Histidine; Human	1974
Postnatal changes in the temperature dependence of synaptosomal amino acid uptake. FEBS letters, 1974, Nov-15, Volume: 48, Issue:2 Topics: Aging; Amino Acids; Animals; Animals, Newborn; Biological Transport; Calorimetry; Cerebral Cortex; G	1974
Intestinal absorption of glycine, L-alanine and L-leucine in the old rat. Experimental gerontology, 1974, Volume: 9, Issue:5-6 Topics: Aging; Alanine; Animals; Biological Transport; Carbon Radioisotopes; Female; Glycine; Intestinal Abs	1974
Glycine N-methyltransferase is a regulatory enzyme which increases in ageing animals. Nature, 1973, Jun-15, Volume: 243, Issue:5407 Topics: Aging; Animals; Glycine; Kidney; Liver; Male; Methyltransferases; Mice; Mice, Inbred C57BL; Rats; tR	1973
Effect of cortisol treatment on free amino acid levels in rats. The Journal of endocrinology, 1973, Volume: 59, Issue:1 Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Glycine; Hydrocortisone; Liver; Male; Muscle Pr	1973
Postnatal changes in the high affinity uptake of glycine and GABA in the rat central nervous system. Journal of neurochemistry, 1974, Volume: 22, Issue:1 Topics: Aging; Alkaloids; Amino Acids; Aminobutyrates; Animals; Animals, Newborn; Antimetabolites; Biologica	1974
Postnatal changes in the levels of glycine and the activities of serine hydroxymethyltransferase and glycine:2-oxoglutarate aminotransferase in the rat central nervous system. Journal of neurochemistry, 1974, Volume: 22, Issue:1 Topics: Aging; Amino Acids; Animals; Animals, Newborn; Antimetabolites; Brain; Carbon Radioisotopes; Cerebel	1974
Free amino acids in developing rat retina. Journal of neurochemistry, 1974, Volume: 22, Issue:6 Topics: Aging; Alanine; Amino Acids; Aminobutyrates; Animals; Arginine; Aspartic Acid; Autoanalysis; Cell Di	1974
Chemical heterogeneity of fetal hemoglobin in subjects with sickle cell anemia, homozygous Hb-C disease, SC disease, and various combinations of hemoglobin variants. Clinica chimica acta; international journal of clinical chemistry, 1972, Volume: 38, Issue:1 Topics: Adolescent; Adult; Aged; Aging; Alanine; Anemia, Sickle Cell; Child; Child, Preschool; Chromatograph	1972
[Urinary amino acids in children and adults with normal metabolism]. Klinische Padiatrie, 1972, Volume: 184, Issue:1 Topics: Adolescent; Aging; Alanine; Amino Acids; Child; Child, Preschool; Chromatography, DEAE-Cellulose; Ch	1972
The ontogeny of amino acid transport in rat kidney. I. Effect on distribution ratios and intracellular metabolism of proline and glycine. Biochimica et biophysica acta, 1971, Dec-03, Volume: 249, Issue:2 Topics: Aging; Aminoisobutyric Acids; Animals; Animals, Newborn; Biological Transport; Carbon Dioxide; Carbo	1971
[Aging processes in collagen (author's transl)]. Altern und Entwicklung. Aging and development, 1971, Volume: 3 Topics: Aging; Animals; Collagen; Connective Tissue; Connective Tissue Cells; Densitometry; Glycine; Humans;	1971
[The amino acid composition of human lens proteins in the course of lens alterations and cataract transformation. I. The amino acid composition of unclouded human lenses of various age groups]. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1966, Dec-15, Volume: 171, Issue:3 Topics: Adult; Age Factors; Aged; Aging; Alanine; Amino Acids; Arginine; Asparagine; Cataract; Crystallins;	1966
The distribution of free amino acids in arterial walls and their modifications during aging. Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1970, Volume: 15, Issue:8 Topics: Aging; Amino Acids; Animals; Aorta; Arteries; Brain Chemistry; Cattle; Female; Glutamates; Glycine;	1970
The role of thrombin in fibrinogen biosynthesis. Thrombosis et diathesis haemorrhagica, 1967, May-31, Volume: 17, Issue:3-4 Topics: Aging; Animals; Arteriosclerosis; Carbon Isotopes; Fibrin; Fibrinogen; Glycine; Humans; Liver; Mice;	1967
[Leukocyte peptide metabolism. II. Aminotripeptidase activity of human leukocytes]. Enzymologia, 1967, Jun-30, Volume: 32, Issue:6 Topics: Adult; Aging; Aminopeptidases; Female; Glycine; Humans; Hydrogen-Ion Concentration; Indicators and R	1967
The effect of platelet age on platelet adherence to collagen. The Journal of clinical investigation, 1968, Volume: 47, Issue:3 Topics: Adenine Nucleotides; Aging; Animals; Blood Platelets; Carbon Isotopes; Collagen; Glycine; In Vitro T	1968
Erythropoietin and the development of erythrocytes. Effect of erythropoietin in vitro which simulates that of a massive dose in vivo. Nature, 1968, Mar-16, Volume: 217, Issue:5133 Topics: Aging; Animals; Bone Marrow Cells; Carbon Isotopes; Cell Differentiation; Cytoplasm; Dactinomycin; E	1968
The uptake of amino acids by particulate fractions from brain. Biochimica et biophysica acta, 1969, Volume: 173, Issue:3 Topics: Aging; Amino Acids; Aminobutyrates; Animals; Animals, Newborn; Aspartic Acid; Biological Transport,	1969
The lens capsule. Sugar and amino acid composition. The Journal of biological chemistry, 1969, Apr-25, Volume: 244, Issue:8 Topics: Aging; Amino Acids; Animals; Carbohydrates; Cattle; Collagen; Fucose; Galactose; Glucosamine; Glucos	1969
Metabolic alterations with senescence of human cells. Effect of ionizing radiation. Journal of gerontology, 1965, Volume: 20, Issue:4 Topics: Aging; Amnion; Carbon Isotopes; Cell Division; Cholesterol; DNA; Glycine; Lipids; Palmitic Acids; Ra	1965

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