glutamic acid has been researched along with Ache in 385 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (5.71) | 18.7374 |
| 1990's | 40 (10.39) | 18.2507 |
| 2000's | 191 (49.61) | 29.6817 |
| 2010's | 107 (27.79) | 24.3611 |
| 2020's | 25 (6.49) | 2.80 |
| Authors | Studies |
|---|---|
| Bang, SK; Cho, SJ; Choi, KH; Kang, SY; Ryu, Y; Seo, SY | 1 |
| Capim, SL; Carvalho, VAN; Côrtes, WDS; de Carvalho Cid, G; Fernandes, TFDC; Gonçalves, GM; Laureano-Melo, R; Marinho, BG; Oliveira, JM; Vasconcellos, MLAA | 1 |
| Cai, D; Lou, W; Mao, X | 1 |
| Bai, Y; Cao, P; Chen, K; Chen, QY; Chen, T; Chen, Y; Fan, BY; Fan, HW; Feng, JM; Geng, AQ; Gu, JX; Kaang, BK; Li, YQ; Liang, Y; Lu, YC; Qiu, XT; Wang, J; Wang, JD; Wang, P; Xing, KK; Yang, SM; Zhang, MM; Zhou, ZX; Zhu, DY; Zhuo, M | 1 |
| Chu, MK; Park, CG | 1 |
| Ally, A; Nauli, AM; Nauli, SM; Sarmah, N | 1 |
| Dimitrov, E; Papadogiannis, A | 1 |
| Baumbach, J; Darvish-Ghane, S; Martin, LJ | 1 |
| Bisatto, NV; Campos, MM; Crescente, BB; Fritscher, GG; Rübensam, G | 1 |
| Li, JX; Luo, JL; Qian, X; Wang, L; Yin, Y; Yu, L; Zhang, XD; Zhao, X; Zhu, Q | 1 |
| da Fonseca, CAR; Echenique, JVZ; Luchese, C; Paltian, JJ; Peglow, TJ; Perin, G; Pinz, MP; Reis, AS; Schumacher, RF; Soares, MP; Vaucher, RA; Vogt, AG; Voss, GT; Wilhelm, EA | 1 |
| Howlader, MMR; Schultz, J; Singh, G; Uddin, Z | 1 |
| Chou, D; Gao, H; Huang, D; Ko, CY; Liu, B; Liu, Q; Ye, L; Zheng, C | 1 |
| Carlsson, A; Ernberg, M; Ghafouri, B; Hedenberg-Magnusson, B; Jasim, H | 2 |
| Archibald, J; Enzler, A; Jutzeler, CR; Kramer, JLK; MacMillan, EL; Schweinhardt, P | 1 |
| Chae, JW; Choi, JI; Kang, DH; Kim, SH; Kim, WM; Lee, HG; Li, Y; Yoon, MH | 1 |
| Baeken, C; De Paepe, B; Meeus, M; Smet, J; Van Oosterwijck, J | 1 |
| Cheung, CW; Gu, P; Iadarola, M; Saligan, L; Ti, LK; Wang, XM; Wong, SSC | 1 |
| Beaulieu, JM; Darvish-Ghane, S; Martin, LJ; Quintana, C | 1 |
| Cruz-Almeida, Y; Porges, E | 1 |
| Archibald, J; Graf, C; Kozlowski, P; Kramer, JLK; Laule, C; MacMillan, EL | 1 |
| Guo, H; Kang, JJ; Liang, YT; Liu, YK; Liu, YY; Luo, C; Ma, SB; Ma, SY; Wu, SX; Wu, WB; Xian, H; Xie, RG; Zhang, H | 1 |
| Aponte, Y; Arenivar, MA; Borja, CB; Eagle, AL; Erbaugh, LJ; Leinninger, G; Robison, AJ; Sarsfield, S; Siemian, JN | 1 |
| Adakudugu, EA; Ameyaw, EO; Anokwah, D; Biney, RP; Henneh, IT; Obese, E; Woode, E | 1 |
| Ellerbrock, I; Fanton, S; Jensen, KB; Kadetoff, D; Kosek, E; Sandström, A; Schalling, M; Sitnikov, R; Tour, J | 1 |
| Alhilou, AM; Cairns, BE; Christidis, N; Ernberg, M; Shimada, A; Svensson, CI; Svensson, P | 1 |
| Ishimura, T; Moffett, JR; Neale, JH; Nonaka, T; Yamada, T; Yamamoto, T; Zuo, D | 1 |
| Abotsi, WKM; Ameyaw, EO; Boakye-Gyasi, E; Henneh, IT; Woode, E | 1 |
| Akasaka, R; Furukawa, A; Honda, K; Iwata, K; Kondo, M; Otsuki, K; Shimizu, K; Shinoda, M; Yonemoto, H | 1 |
| Jiang, YM; Jiao, Y; Li, T; Li, YJ; Liu, Y; Ouyang, JF; Sun, DD; Wang, DQ; Wang, ZG; Zhao, XL | 1 |
| Hong, JW; Jang, SP; Lee, HJ; Lee, JR; Park, SH; Suh, HW | 1 |
| Boccella, S; de Novellis, V; Farina, A; Guida, F; Iannotta, M; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Serra, N | 1 |
| Charles, A; Hoffmann, J | 1 |
| Bourbia, N; Pertovaara, A | 1 |
| Fernandes, PD; Giorno, TBS; Moreira, IGDS; Rezende, CM | 1 |
| Andrade Próspero, DF; de Castro Almeida, FR; de Sousa, DP; Lopes, EM; Piauilino, CA; Reis Filho, AC | 1 |
| Akhtar, MN; Akira, A; Israf Ali, DA; Perimal, EK; Ping, CP; Sulaiman, MR; Tengku Mohamad, TAS | 1 |
| Goulart, HA; Luchese, C; Peglow, TJ; Perin, G; Pinz, MP; Reis, AS; Schumacher, RF; Soares, LK; Wilhelm, EA | 1 |
| Brummelte, S; Mooney-Leber, SM; Spielmann, SS | 1 |
| Ali, MW; Gao, M; Hooks, SB; Li, F; Maixner, DW; Weng, HR; Yadav, R; Yan, X | 1 |
| Baumgärtner, U; Cardinale, V; Ende, G; Gradinger, T; Sack, M; Schmahl, C; Thiacourt, M | 1 |
| Santana, DG; Santos, CA; Santos, DS; Thomazzi, SM | 1 |
| Cherng, CH; Wong, CS; Wu, CT; Yeh, CC | 1 |
| Kang, YJ; Kim, CH; Kim, SJ; Kim, SS; Lim, SM; Park, SH; Sim, YB; Suh, HW | 1 |
| Kaneko, S; Nakagawa, T | 1 |
| Seidlitz, EP; Singh, G; Ungard, RG | 1 |
| Batista, R; de Campos-Buzzi, F; Filho, VC; Guimarães, AF; Romanos, MT; Silva Júnior, Ade J; Wagner, TM | 1 |
| Coutinho, MR; Ferreira, MD; Menescal-de-Oliveira, L; Zugaib, J | 1 |
| Almeida, AF; Almeida, EC; Araujo, BS; Cunha, RS; Curvello, RL; Damascena, NP; Dias, AS; Estevam, CS; Lima, AC; Paixão, MS; Quintans Júnior, LJ; Santos, CC; Souza, LM; Souza, MT | 1 |
| Almeida, FR; Amaral, MP; Chaves, MH; Costa, DA; Figueiredo, KA; Júnior, FB; Oliveira, FA; Oliveira, IS; Oliveira, RC; Silva, FV | 1 |
| Boylan, F; Dias Fernandes, P; Miltojević, AB; Pinheiro, MM; Radulović, NS | 1 |
| Cui, Y; Jiao, Y; Liu, Y; Sun, DD; Wang, DQ; Wang, Y; Xu, S; Xu, XJ; Zhang, MY; Zhang, Y; Zhao, XL | 1 |
| Imam, MZ; Moniruzzaman, M | 1 |
| Bourbia, N; Pertovaara, A; Sagalajev, B | 1 |
| Andrés, E; Fayed, N; Garcia-Campayo, J; Modrego, PJ; Viguera, L | 1 |
| Hasse, DR; Rates, SM; Stolz, ED; von Poser, GL | 1 |
| Brüning, CA; Gai, BM; Martini, F; Nogueira, CW; Soares, SM | 1 |
| Delgado Rodrigues, RN; Goulart, LI; Prieto Peres, MF | 1 |
| Basting, RT; Bauer, S; Costa, MF; Dos Santos, C; Hiruma-Lima, CA; Laufer, S; Lopes, JA; Lucena Périco, L; Nishijima, CM; Rocha, LR; Santos, AR; Santos, LC; Santos, RC; Vilegas, W | 1 |
| Berestovitskaia, VM; Perfilova, VN; Sadikova, NV; Vasil'eva, OS | 1 |
| Guindon, J; Lin, JS | 1 |
| Ferdous, A; Irin, S; Moniruzzaman, M | 1 |
| Fazzari, J; Lin, H; Murphy, C; Singh, G; Ungard, R | 1 |
| Bortolatto, CF; da Rocha, JT; Duarte, T; Nogueira, CW; Quines, CB; Rosa, SG | 1 |
| Imam, MZ; Khatun, A; Rana, MS | 1 |
| Belo Neto, R; Berretta E Silva, AA; Cordeiro Cardoso, J; de Souza Santos, J; Divino de Araujo, E; Lima Cavendish, R; Maria Thomazzi, S; Oliveira Paixão, A; Valéria Oliveira, J; Zanardo Gomes, M | 1 |
| Coelho, IS; Junqueira, SC; Maldaner, G; Morel, AF; Pizzolatti, MG; Ruani, AP; Santos, AR; Simões, RR; Venzke, D; Zanchet, EM | 1 |
| Eisenach, JC; Hayashida, K; Kimura, M; Suto, T | 1 |
| Almeida, A; Amorim, D; Pertovaara, A; Pinto-Ribeiro, F; Viisanen, H; Wei, H | 1 |
| Brumovsky, PR; Malet, M | 1 |
| Bagetta, G; Mizoguchi, H; Sakurada, S; Watanabe, C | 2 |
| Bhattacharjee, PS; Hossain, MS; Moniruzzaman, M | 1 |
| Awouafack, MD; Kamanyi, A; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD; Wandji, BA | 1 |
| Endo, Y; Nemoto, W; Shima, K; Sugawara, S; Takano-Yamamoto, T; Tan-No, K; Tsuchiya, M | 1 |
| Bingel, U; Harris, RE; Schmidt-Wilcke, T; Schweizer, LM; Witte, V; Zunhammer, M | 1 |
| Fujita, T; Kumamoto, E; Piao, LH; Yu, T | 1 |
| Coderre, TJ; Kumar, N; Laferrière, A; Vincent, K; Wang, SF | 1 |
| Khan, MF; Khatun, A; Mannan, MA | 1 |
| Breton, JD; Freund-Mercier, MJ; Poisbeau, P; Schlichter, R; Uhl-Bronner, S; Veinante, P; Vergnano, AM | 1 |
| de Souza, MM; Filho, AW; Filho, VC; Olinger, L | 1 |
| Choi, HW; Choi, SM; Jung, JS; Kim, YW; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Suh, HW | 1 |
| Abel, T; Isiegas, C; Kaang, BK; Kim, SS; Steenland, HW; Wu, LJ; Zhuo, M | 1 |
| Jesse, CR; Nogueira, CW; Rocha, JB; Savegnago, L | 1 |
| Coelho, IS; Dafre, AL; Franco, JL; Meotti, FC; Rocha, JB; Santos, AR | 1 |
| Lim, G; Mao, J; Sung, B; Wang, S; Yang, L; Zeng, Q | 1 |
| Clemente, FR; Somers, DL | 1 |
| Al-Khater, KM; Polgár, E; Shehab, S; Todd, AJ; Watanabe, M | 1 |
| Almeida, A; Ansah, OB; Gonçalves, L; Pertovaara, A | 1 |
| Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO | 1 |
| Arendt-Nielsen, L; Gibson, W; Graven-Nielsen, T; Sessle, BJ | 1 |
| Mense, S | 1 |
| Mermelstein, PG | 1 |
| Arendt-Nielsen, L; Ge, HY; Kimura, M; Kimura, Y; Sumikura, H; Zhang, Y | 1 |
| Cui, L; Kim, H; Kim, J; Kim, SJ | 1 |
| Arendt-Nielsen, L; Ge, HY; Kimura, Y; Yue, SW; Zhang, Y | 1 |
| Hernández, L; Páez, X; Quiñones, B; Silva, E | 1 |
| Landry, M; Nagy, F | 1 |
| Calixto, JB; Chaves, J; Ferreira, VM; Guginski, G; Luiz, AP; Martins, DF; Massaro, M; Mattos, RW; Santos, AR; Silva, MD; Silveira, D | 1 |
| Ardenghi, JV; Bresciani, LF; Cechinel-Filho, V; De Souza, MM; Delle Monache, F; Mora, TC; Pereira, MA; Yunes, RA | 1 |
| Antunes, C; Böhmer, AE; Elisabetsky, E; Leke, R; Pereira, MS; Schallenberger, C; Schmidt, AP; Souza, DO; Wofchuk, ST | 1 |
| Duan, B; Xu, TL | 1 |
| Radhakrishnan, R; Sluka, KA | 1 |
| Baggio, CH; dos Santos, AC; dos Santos, AR; dos Santos, CA; Freitas, CS; Luiz, AP; Marques, MC; Mayer, B; Twardowschy, A | 1 |
| Chu, J; Lin, BC; Liu, WY; Wang, CH; Wang, G; Xu, H; Yang, J; Yang, Y | 1 |
| Hammond, DL; Zhang, L | 1 |
| Lin, B; Liu, W; Ni, N; Song, C; Wang, G; Xu, H; Yang, D; Yang, J; Yuan, H | 1 |
| Mishra, R; Semwal, A; Sriram, D; Yogeeswari, P | 1 |
| Chu, J; Lin, BC; Liu, WY; Wang, G; Xu, H; Yang, J; Yang, Y; Yuan, H | 1 |
| Khodorova, A; Richter, J; Strichartz, G; Vasko, MR | 1 |
| Cechinel-Filho, V; Corrêa, R; de Campos-Buzzi, F; Delle Monache, F; Fracasso, M; Niero, R; Padaratz, P | 1 |
| Minami, M | 1 |
| Katsuyama, S; Komatsu, T; Sakurada, S; Sakurada, T; Sanai, K | 1 |
| Bobeck, EN; Ingram, SL; Morgan, MM | 1 |
| Erdtel, M; Gussew, A; Kaiser, WA; Mentzel, HJ; Reichenbach, JR; Rzanny, R; Scholle, HC | 1 |
| Clauw, DJ; Craig, AD; Harris, RE; Kirshenbaum, E; Napadow, V; Sen, A; Sundgren, PC | 1 |
| Larsson, M | 1 |
| Kondo, S; Matsumoto, M; Ueda, H; Usdin, TB | 1 |
| Palecek, J; Spicarova, D | 1 |
| Eisenach, JC; Hayashida, K; Parker, RA | 1 |
| Fang, L; Lin, Q; Wang, Y; Wu, J; Wu, Z; Yue, Y | 1 |
| Cao, DY; Guo, Y; Li, L; Luo, R; Pickar, JG; Wang, J; Zhao, Y | 1 |
| Antonialli, CS; Corrêa, R; da Silva, GF; de Campos-Buzzi, F; Filho, VC; Quintão, NL | 1 |
| Almeida, FR; Chaves, MH; Costa, DA; Figueiredo, KA; Lopes, LS; Marques, RB; Pereira, SS | 1 |
| Coelho, Idos S; Meotti, FC; Santos, AR | 1 |
| Chung, CC; MacLeod, BA; Ries, CR; Schwarz, SK; Wang, JT; Whitehead, RA | 1 |
| Chung, CC; MacLeod, BA; Puil, E; Ries, CR; Schwarz, SK; Wang, JT | 1 |
| Gao, HR; Jiao, RS; Shi, TF; Xu, MY; Yang, CX; Yang, DX; Zhang, D; Zhang, GW | 1 |
| Kerr, BJ; Leighton, J; Miller, B; Olechowski, CJ; Parmar, A; Stephan, J; Tenorio, G; Tran, K | 1 |
| Coderre, TJ; Kumar, N; Laferriere, A; Poon, T; Yu, JS | 1 |
| Del Vecchio, F; Dias, QM; Garcia-Cairasco, N; Prado, WA; Reis, GM; Silveira, JW | 1 |
| Fan, XQ; Hao, F; Li, H; Li, XP; Li, XY; Lin, BC; Liu, WY; Wang, DX; Yan, FL; Yan, XQ; Yang, J; Zhou, XJ | 1 |
| Nakagawa, T | 1 |
| Arsenault, I; Athanassiadis, T; Auclair, F; Caram Salas, N; Kolta, A; Lund, JP; Rompré, P; Sadeghi, S; Thivierge, B; Westberg, KG | 1 |
| Andres, E; Andrés-Bergareche, H; Beltrán, J; Fayed, N; Garcia-Campayo, J; Luciano, JV; Magallón, R | 1 |
| Baker, SJ; Bianchi, BR; Faltynek, CR; Gauvin, DM; Han, P; Honore, P; Joshi, SK; Koenig, JR; Kort, ME; Kym, PR; Lewis, GR; Mikusa, JP; Neelands, TR; Perner, RJ; Puttfarcken, PS; Reilly, RM | 1 |
| Crenshaw, AG; Fahlström, M; Flodgren, GM; Hellström, F | 1 |
| Liu, XJ; Salter, MW | 1 |
| Bao, L; Gong, LQ; Li, KC; Li, ZY; Lin, LB; Liu, XJ; Lu, YJ; Xiao, HS; Yao, JR; Zhang, FX; Zhang, X; Zhang, XH | 1 |
| Abe, T; Ito, S; Katano, T; Kunori, S; Mabuchi, T; Matsumura, S; Nakazawa, T; Okuda-Ashitaka, E; Watanabe, M; Yamamoto, T | 1 |
| Dasilva, D; Freedman, SD; Fregni, F; Lenkinski, RE; Pascual-Leone, A; Potvin, K; Wang, X | 1 |
| Akhtar, MN; Israf, DA; Khalid, MH; Khalid, S; Lajis, NH; Mohamad, AS; Mohd, PA; Perimal, EK; Sulaiman, MR; Zakaria, ZA | 1 |
| Harrington, JF; Harrington, WF; Kenney, EV; Osgood, DP | 1 |
| Binkert, CA; Brügger, M; Ettlin, DA; Froehlich, JM; Graf, N; Gutzeit, A; Meier, D; Meier, ML; von Weymarn, C | 1 |
| Abdel Samad, O; Duan, B; Ji, RR; Liu, Y; Lopes, C; Lowell, BB; Ma, Q; Tong, Q; Zhang, L | 1 |
| Higashi, H; Tadano, T; Tan-No, K; Watanabe, S | 1 |
| Guan, X; Lu, W; Petralia, RS; Rothstein, JD; Tao, YX; Yaster, M | 1 |
| Hoffman, EM; Miller, KE; Schechter, R; Sutharshan, M | 1 |
| Hao, F; Li, P; Liang, JY; Pan, YJ; Qiu, PY; Wang, DX; Yan, FL; Yang, J; Zhang, J; Zhang, XY | 1 |
| Jung, JS; Kang, YJ; Kim, SM; Lee, JK; Park, SH; Sim, YB; Suh, HW | 1 |
| Akhtar, MN; Akira, A; Israf, DA; Khalid, MH; Lajis, N; Mohamad, AS; Perimal, EK; Sulaiman, MR | 1 |
| Ally, A; Chaitoff, KA; Maher, TJ; Tedesco, A; Toner, F | 1 |
| Almeida, A; Ansah, OB; Pertovaara, A; Pinto-Ribeiro, F | 1 |
| da Silva, MA; de Oliveira, SM; dos Santos, GT; Drewes, CC; Ferreira, J; Gewehr, C; Guerra, GP; Pazini, AM; Rossato, MF; Rubin, MA | 1 |
| Carlton, SM; Du, J; Govea, R; Zhou, S | 1 |
| Arendt-Nielsen, L; Bendtsen, L; Buchgreitz, L; Egsgaard, LL; Jensen, R; Wang, L | 1 |
| Rojas, C; Slusher, BS; Wozniak, KM; Wu, Y | 1 |
| Dias, QM; Fais, RS; Petronilho, A; Prado, WA; Reis, GM | 1 |
| Arendt-Nielsen, L; Cairns, BE; Castrillon, EE; Svensson, P; Wang, K | 1 |
| Lu, XY; Ma, X; Shi, DX; Shi, TF; Wang, CL; Xu, MY; Yang, CX; Yang, Y; Zhang, M; Zhang, S; Zhu, D | 1 |
| Bum, EN; Dawe, A; De Waard, M; Dimo, T; Dzeufiet, PD; Nguimbou, RM; Sidiki, N; Taïwe, GS; Talla, E | 1 |
| Kiyatkin, EA; Wakabayashi, KT | 1 |
| Gmiro, VE; Serdiuk, SE | 1 |
| Ben Achour, S; Pascual, O | 1 |
| Malmierca, E; Martin, YB; Nuñez, A | 1 |
| Byun, HS; Chen, H; Chen, SR; Han, HD; Li, L; Lopez-Berestein, G; Pan, HL; Sood, AK; Zhou, HY | 1 |
| Carceller, A; Fernández-Pastor, B; Merlos, M; Vela, JM; Vidal-Torres, A; Zamanillo, D | 1 |
| Andrés, E; Arcega, R; Garcia-Campayo, J; López-del-Hoyo, Y; Magallon, R; Masluk, B; Olivan-Blázquez, B; Pérez-Yus, MC; Puebla, M; Roca, M | 1 |
| Anderson, J; Correa, L; Lorrain, DS; Varney, M | 1 |
| Ebersberger, A; Schaible, HG; Von Banchet, GS | 1 |
| Bai, ZT; Chen, B; Ji, YH; Shen, J; Zhang, JW; Zhang, XY | 1 |
| Clark, JD; Li, X | 1 |
| Geisslinger, G; Meller, ST; Tegeder, L; Zimmermann, J | 1 |
| Chizh, BA | 1 |
| Gear, RW; Levine, JD; Parada, CA; Tambeli, CH | 1 |
| Bereiter, DA; Cairns, BE; Hu, JW; Sessle, BJ; Sim, Y | 1 |
| Arendt-Nielsen, L; Cairns, BE; Graven-Nielsen, T; Hu, JW; Sessle, BJ; Svensson, P; Wang, K | 1 |
| Zhuo, M | 2 |
| Beirith, A; Calixto, JB; Santos, AR | 1 |
| Choi, SS; Han, EJ; Han, KJ; Kim, DH; Lee, HK; Lee, JK; Suh, HW | 1 |
| Arendt-Nielsen, L; Berde, CB; Cairns, BE; Graven-Nielsen, T; Hupfeld, S; Sessle, BJ; Svensson, P; Wang, K | 1 |
| Holden, C | 1 |
| Bleich, S; Kornhuber, J; Römer, KD | 1 |
| ZAKRZEWSKI, T | 1 |
| Jia, H; Tang, JS; Xie, YF | 1 |
| Martinez, A; Morales-Alcelay, S; Rubio, L | 1 |
| Ando, R; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Watanabe, C | 1 |
| Hefferan, MP; Loomis, CW; O'Rielly, DD | 1 |
| Chang, YC; Cherng, CH; Tao, PL; Wang, JJ; Wen, ZH; Wong, CS | 1 |
| Kirouac, GJ; Li, S; Mabrouk, G | 1 |
| Aoki, KR; Cui, M; Khanijou, S; Rubino, J | 1 |
| Andrews, NA; Blake, R; Maneuf, YP; McKnight, AT | 1 |
| Fields, HL; Johansen, JP | 1 |
| Bursztajn, S; Deleo, JA; Rutkowski, MD | 1 |
| Geenen, R; Jacobs, JW; Janssens, EL; van Staveren, W | 1 |
| Dmitrieva, N; Hernández, L; Pérez, J; Rodríguez-Malaver, AJ | 1 |
| Arendt-Nielsen, L; Sessle, BJ; Svensson, P; Wang, K | 1 |
| Hansson, E; Rönnbäck, L | 1 |
| Allen, G; Aumeerally, N; Sawynok, J | 1 |
| Gao, YJ; Lei, LG; Sun, S; Zhang, YQ; Zhao, ZQ | 1 |
| Burette, A; Hwang, SJ; Rustioni, A; Valtschanoff, JG | 1 |
| Gerdle, B; Kjær, M; Kristiansen, J; Larsson, B; Peolsson, M; Rosendal, L; Søgaard, K; Sørensen, J | 1 |
| Aono, Y; Cools, AR; Fusa, K; Ikeda, H; Koshikawa, N; Nagase, H; Saigusa, T; Suzuki, T; Takahashi, I; Watanabe, S | 1 |
| Arendt-Nielsen, L; Ge, HY; Madeleine, P | 1 |
| Calixto, JB; Cani, GS; Ferreira, J; Lima, FV; Malheiros, A; Meyre-Silva, C; Muller, LA; Otuki, MF; Santos, AR; Yunes, RA | 1 |
| Cairns, BE; Svensson, P | 1 |
| Lv, N; Xu, MY; Zhang, XJ | 1 |
| Minami, M; Satoh, M | 1 |
| Barker, K; Dykhuizen, M; Harrington, JF; Hoffman, L; Messier, AA; Yu, E | 1 |
| Donnerer, J; Liebmann, I; Lippe, IT; Schicho, R | 1 |
| Binns, BC; Goettl, VM; Hackshaw, KV; Huang, Y; Stephens, RL | 1 |
| Mao, J | 1 |
| Binns, BC; Chu, Y; Johns, RA; Liaw, WJ; Rothstein, JD; Sepkuty, JP; Stephens, RL; Tao, YX | 1 |
| Ashina, M; Bendtsen, L; Jensen, R; Jorgensen, M; Mork, H; Olesen, J; Pedersen, JF; Stallknecht, B | 1 |
| Huang, PT; Wen, L; Yang, S; Zhang, YX; Zhou, WX; Zhou, XW | 1 |
| Arendt-Nielsen, L; Cairns, BE; Sessle, BJ; Svensson, P; Wang, K | 1 |
| Jung, RE; Mullins, PG; Rowland, LM; Sibbitt, WL | 1 |
| Fang, L; Lei, Y; Willis, WD; Wu, J; Zhang, X | 1 |
| Komatsu, T; Sakurada, S; Sakurada, T | 1 |
| Salter, MW | 1 |
| Inomata, S; Kakiuchi, Y; Kohda, Y; Miyabe, M; Ohara, Y; Osaka, Y; Sukegawa, I; Toyooka, H | 1 |
| Allchorne, A; Amaya, F; Brenner, GJ; Ito, N; Ji, RR; Kohno, T; Wang, H; Woolf, CJ | 1 |
| Cao, DY; Guo, Y; Tian, YL; Wang, HS; Zhang, Q; Zhao, Y | 1 |
| Cairns, BE; Hu, JW; Lam, DK; Sessle, BJ | 1 |
| Balciuniene, I; Juskiene, I; Sabalaite, R | 1 |
| Gogas, KR | 1 |
| Caudle, RM; Del Valle-Pinero, AY; Price, DD; Verne, GN; Zhou, Q | 1 |
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| Beirith, A; Calixto, JB; Creczynski-Pasa, TB; Rodrigues, AL; Santos, AR | 1 |
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| Lawand, NB; McNearney, T; Westlund, KN | 1 |
| Milbrandt, J; Qu, Z; Wei, F; Xu, ZC; Zhuo, M | 1 |
| Alba, G; Contreras, Q; Guerrero, F; Hernandez, L; Silva, E | 1 |
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| Hassall, DC; Morrow, LA; Watts, DC; Wilson, NH | 1 |
| Cheng, JK; Lin, CR; Marsala, M; Tsai, PS; Wen, GH; Yang, LC | 1 |
| Ito, S; Matsumura, S; Minami, T; Mishina, M; Mori, H; Okuda-Ashitaka, E; Sakimura, K; Shimamoto, K | 1 |
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| Chen, SR; Pan, HL; Slusher, BS; Wozniak, KM | 1 |
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| Chen, J; Furue, H; Kumamoto, E; Luo, C; Yoshimura, M | 1 |
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52 review(s) available for glutamic acid and Ache
| Article | Year |
|---|---|
Interactions among Endothelial Nitric Oxide Synthase, Cardiovascular System, and Nociception during Physiological and Pathophysiological States.
Topics: Animals; Blood Pressure; Cardiovascular System; Glutamic Acid; Heart Rate; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Nociception; Pain | 2022 |
Current status of GABA receptor subtypes in analgesia.
Topics: Analgesia; Animals; Chloride Channels; gamma-Aminobutyric Acid; Glutamic Acid; Mammals; Neurotransmitter Agents; Pain; Pain Management; Receptors, G-Protein-Coupled; Receptors, GABA | 2023 |
Glutamate sensing in biofluids: recent advances and research challenges of electrochemical sensors.
Topics: Animals; Biomarkers; Biosensing Techniques; Electrochemical Techniques; Electrodes; Glutamic Acid; Humans; Neoplasms; Neurodegenerative Diseases; Pain | 2020 |
Excitatory and inhibitory responses in the brain to experimental pain: A systematic review of MR spectroscopy studies.
Topics: Brain; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Pain; Pain Threshold | 2020 |
Glutamate and Its Receptors as Therapeutic Targets for Migraine.
Topics: Animals; Central Nervous System Sensitization; Cortical Spreading Depression; Glutamic Acid; Humans; Migraine Disorders; Pain; Receptors, Ionotropic Glutamate; Receptors, Metabotropic Glutamate | 2018 |
SLC1 glutamate transporters and diseases: psychiatric diseases and pathological pain.
Topics: Amino Acid Transport System ASC; Animals; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Minor Histocompatibility Antigens; Mood Disorders; Pain; Schizophrenia; Substance-Related Disorders; Synaptic Transmission | 2013 |
Restless legs syndrome and pain disorders: what's in common?
Topics: Calcium Channel Blockers; Diagnosis, Differential; Dopamine Agonists; Fibromyalgia; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hypnotics and Sedatives; Iron; Melatonin; Migraine Disorders; Pain; Polyneuropathies; Restless Legs Syndrome; Serotonin; Sleep Deprivation; Vitamin D | 2014 |
VGLUTs and Glutamate Synthesis-Focus on DRG Neurons and Pain.
Topics: Animals; Ganglia, Spinal; Glutamic Acid; Humans; Neurons; Pain; Vesicular Glutamate Transport Proteins | 2015 |
Membrane-localised oestrogen receptor alpha and beta influence neuronal activity through activation of metabotropic glutamate receptors.
Topics: Animals; Brain; Caveolins; Cell Membrane; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Gene Expression; Glutamic Acid; Neurons; Pain; Receptors, Metabotropic Glutamate; Sex Characteristics; Sexual Behavior, Animal; Signal Transduction; Spinal Cord | 2009 |
[GABA(B) receptors and sensitization to pain].
Topics: 14-3-3 Proteins; Allosteric Regulation; Animals; Baclofen; Calcium Channels; Calcium-Binding Proteins; Chronic Disease; Dimerization; Extracellular Matrix Proteins; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hyperalgesia; Mice; Mice, Knockout; Nerve Tissue Proteins; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Receptors, GABA-B | 2009 |
Calcium-permeable acid-sensing ion channel in nociceptive plasticity: a new target for pain control.
Topics: Animals; Calcium Channels; Chromosome Pairing; Glutamic Acid; Humans; Neuronal Plasticity; Neurons; Nociceptors; Pain | 2009 |
Current approaches with the glutamatergic system as targets in the treatment of neuropathic pain.
Topics: Animals; Drug Delivery Systems; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neuralgia; Pain; Treatment Outcome | 2009 |
Neuronal mechanisms for pain-induced aversion behavioral studies using a conditioned place aversion test.
Topics: Affect; Amygdala; Animals; Conditioning, Psychological; Glutamic Acid; Gyrus Cinguli; Humans; Models, Neurological; Neural Pathways; Neurons; Norepinephrine; Pain; Septal Nuclei | 2009 |
Mechanism of allodynia evoked by intrathecal morphine-3-glucuronide in mice.
Topics: Animals; Astrocytes; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Injections, Spinal; Mice; Morphine Derivatives; Nitric Oxide; Pain; Spinal Cord; Substance P | 2009 |
Ionotropic glutamate receptors in spinal nociceptive processing.
Topics: Afferent Pathways; Animals; Glutamic Acid; Humans; Hyperalgesia; Ion Channel Gating; Neuronal Plasticity; Neurons, Afferent; Pain; Receptors, Glutamate; Spinal Cord; Synaptic Transmission | 2009 |
Regulation of AMPA receptors in spinal nociception.
Topics: Animals; Glutamic Acid; Humans; Pain; Phosphorylation; Protein Subunits; Protein Transport; Receptors, AMPA; Sensory Receptor Cells; Spinal Cord; Synaptic Transmission | 2010 |
[Involvement of dysfunction of glia-neuron network in chronic pain and drug addiction].
Topics: Adenosine Triphosphate; Animals; Chronic Disease; Endocytosis; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Nerve Net; Nervous System Diseases; Neuroglia; Neuronal Plasticity; Neurons; Pain; Substance-Related Disorders; Synaptic Transmission; TRPC Cation Channels | 2010 |
Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn.
Topics: Animals; Glutamic Acid; Humans; Neuronal Plasticity; Pain; Phosphorylation; Posterior Horn Cells; Protein Transport; Receptors, Glutamate; Spinal Cord | 2010 |
Glutamate pharmacology and metabolism in peripheral primary afferents: physiological and pathophysiological mechanisms.
Topics: Afferent Pathways; Animals; Glutamic Acid; Humans; Pain; Peripheral Nerves; Receptors, Glutamate; Synaptic Transmission | 2011 |
The role of glutamate signaling in pain processes and its regulation by GCP II inhibition.
Topics: Analgesics; Animals; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Nociception; Pain; Receptors, Glutamate; Signal Transduction | 2012 |
Astrocyte-neuron communication: functional consequences.
Topics: Adenosine Triphosphate; Animals; Astrocytes; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Memory; Neurons; Pain; Respiration; Serine; Sleep; Synaptic Transmission; Wakefulness | 2012 |
Mechanisms of pain in arthritis.
Topics: Afferent Pathways; Analgesics, Non-Narcotic; Animals; Arthritis; Cyclooxygenase Inhibitors; Dinoprostone; Efferent Pathways; Ganglia, Spinal; Glutamic Acid; Humans; Hyperalgesia; Inflammation Mediators; Ion Channel Gating; Mechanoreceptors; Models, Biological; Neuropeptides; Nociceptors; Pain; Rats; Receptors, Neuropeptide; Receptors, Neurotransmitter; Receptors, Prostaglandin E; Spinal Cord | 2002 |
Novel approaches to targeting glutamate receptors for the treatment of chronic pain: review article.
Topics: Analgesics; Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ligands; Pain; Receptors, Glutamate | 2002 |
Synaptic and molecular mechanisms of glutamatergic synapses in pain and memory.
Topics: Animals; Brain; Glutamic Acid; Humans; Memory; Mice; Pain; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2003 |
[Glutamate--a transmitter in the tensionfield between toxin and trophine].
Topics: Animals; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Humans; Nerve Growth Factors; Neurotoxins; Neurotransmitter Agents; Pain; Receptors, Glutamate; Synaptic Transmission | 2003 |
AMPA glutamate receptors and neuropathic pain.
Topics: Analgesics; Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Pain; Peripheral Nervous System Diseases; Receptors, AMPA | 2003 |
Hypothesis - dietary glutamate will not affect pain in fibromyalgia.
Topics: Diet; Fibromyalgia; Glutamic Acid; Humans; Pain | 2004 |
Altered neuronal-glial signaling in glutamatergic transmission as a unifying mechanism in chronic pain and mental fatigue.
Topics: Animals; Chronic Disease; Glutamic Acid; Humans; Mental Fatigue; Neuroglia; Neurons; Pain; Spinal Cord | 2004 |
[Roles of the amygdala in pain-related aversive responses].
Topics: Affect; Amygdala; Animals; Glutamic Acid; Humans; Pain; Proto-Oncogene Proteins c-fos; Receptors, Opioid, mu; RNA, Messenger; Signal Transduction | 2005 |
[Involvement of N-type calcium channels in pain and antinociception].
Topics: Animals; Calcium Channels, N-Type; Ganglia, Spinal; Glutamic Acid; Humans; Nociceptors; Pain; Pain Threshold; Substance P | 2005 |
Mechanisms of nociception evoked by intrathecal high-dose morphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Glutamic Acid; Humans; Injections, Spinal; Morphine; Nitric Oxide; Pain; Rats; Spinal Cord; Substance P | 2005 |
Cellular signalling pathways of spinal pain neuroplasticity as targets for analgesic development.
Topics: Analgesics; Drug Design; Excitatory Postsynaptic Potentials; Glutamic Acid; Microglia; Neuronal Plasticity; Pain; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2005 |
Neural mechanisms of temporomandibular joint and masticatory muscle pain: a possible role for peripheral glutamate receptor mechanisms.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Masticatory Muscles; Pain; Receptors, Glutamate; Temporomandibular Joint Dysfunction Syndrome | 2005 |
Glutamate-based therapeutic approaches: NR2B receptor antagonists.
Topics: Animals; Brain Ischemia; Clinical Trials as Topic; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Huntington Disease; Pain; Phenols; Piperidines; Protein Conformation; Receptors, N-Methyl-D-Aspartate | 2006 |
Pain signalling pathways: from cytokines to ion channels.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Cyclooxygenase 2; Cytokines; Glutamic Acid; Humans; Ion Channels; Models, Biological; Nerve Growth Factor; Pain; Prostaglandins; Serotonin; Signal Transduction; TRPC Cation Channels | 2007 |
[Pain and glutamate receptors].
Topics: Analgesics; Animals; Glutamic Acid; Humans; Long-Term Potentiation; Nitric Oxide; Nociceptors; Pain; Posterior Horn Cells; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2007 |
MAGUK proteins: new targets for pharmacological intervention in the glutamatergic synapse.
Topics: Alzheimer Disease; Animals; Antiparkinson Agents; Chronic Disease; Disks Large Homolog 4 Protein; Dyskinesia, Drug-Induced; Glutamic Acid; Guanylate Kinases; Humans; Huntington Disease; Intracellular Signaling Peptides and Proteins; Levodopa; Membrane Proteins; Pain; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Stroke; Synapses | 2008 |
Microdialysis in central nervous system disorders and their treatment.
Topics: Animals; Brain Injuries; Calibration; Central Nervous System Diseases; Glutamic Acid; Hydroxyl Radical; Microdialysis; Neurons; Pain; Reactive Oxygen Species; Spinal Cord Injuries; Zinc | 2008 |
Balances between excitatory and inhibitory events in the spinal cord and chronic pain.
Topics: Animals; Chronic Disease; Glutamic Acid; Humans; Neural Inhibition; Pain; Spinal Cord | 1996 |
The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord.
Topics: Animals; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hyperalgesia; Neural Inhibition; Pain; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1997 |
Glutamate: a role in normal brain function, anaesthesia, analgesia and CNS injury.
Topics: Analgesia; Anesthetics, General; Central Nervous System; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Humans; Memory; Pain; Receptors, Glutamate; Synaptic Transmission | 1997 |
The neurochemistry of central pain: evidence from clinical studies, hypothesis and therapeutic implications.
Topics: Anesthetics, Intravenous; Baclofen; Cerebral Cortex; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Midazolam; Middle Aged; Pain; Propofol; Thalamus | 1998 |
The glutamate synapse: a target in the pharmacological management of hyperalgesic pain states.
Topics: Animals; Glutamic Acid; Humans; Hyperalgesia; Nociceptors; Pain; Receptors, Amino Acid; Synapses | 1998 |
[Biochemistry of pain].
Topics: Afferent Pathways; Animals; Capsaicin; Glutamic Acid; Humans; Narcotics; Nerve Growth Factors; Neurons, Afferent; Pain; Peripheral Nerves; Prostaglandins; Spinal Cord; Substance P | 1999 |
Central mechanisms in pain.
Topics: Central Nervous System; Glutamic Acid; Humans; Pain; Spinal Cord; Substance P | 1999 |
Activity-dependent changes in the pain matrix.
Topics: Animals; Arthritis, Experimental; Autoradiography; Carbon Radioisotopes; Deoxyglucose; Electrophysiology; Glutamic Acid; Motor Activity; Neurons; Pain; Rats; Receptors, Glutamate; Spinal Cord; Substance P; Synaptic Transmission | 2000 |
Chemical mediators of pain due to tissue damage and ischemia.
Topics: Acetylcholine; Acid Sensing Ion Channels; Adenosine; Adenosine Triphosphate; Afferent Pathways; Animals; Bradykinin; Glutamic Acid; Heart; Humans; Lactic Acid; Membrane Proteins; Myocardial Ischemia; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Pain; Potassium; Proton Pumps; Receptors, Purinergic P2; Signal Transduction; Sodium Channels | 2000 |
Silent glutamatergic synapses and long-term facilitation in spinal dorsal horn neurons.
Topics: Animals; Efferent Pathways; Glutamic Acid; Humans; Long-Term Potentiation; Nociceptors; Pain; Posterior Horn Cells; Protein Kinase C; Receptors, Glutamate; Serotonin; Signal Transduction; Synapses; Synaptic Transmission | 2000 |
Glutamate receptors and nociception: implications for the drug treatment of pain.
Topics: Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Models, Biological; Pain; Pain Measurement; Receptors, Glutamate | 2001 |
Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Brain; Cattle; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Synergism; Glutamic Acid; Humans; Hyperalgesia; Inflammation; Isoenzymes; Membrane Proteins; Mice; Mice, Knockout; Models, Animal; Models, Biological; Neuralgia; Neuronal Plasticity; Nitric Oxide; Nociceptin; Nociceptors; Opioid Peptides; Pain; Peripheral Nerves; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Precursors; Rats; Spinal Cord; Thromboxane-A Synthase | 2001 |
Chronic tendon pain: no signs of chemical inflammation but high concentrations of the neurotransmitter glutamate. Implications for treatment?
Topics: Animals; Chronic Disease; Glutamic Acid; Humans; Microdialysis; Pain; Pain Management; Receptors, N-Methyl-D-Aspartate; Tendinopathy | 2002 |
Plasticity of the hippocampus: adaptation to chronic stress and allostatic load.
Topics: Adaptation, Physiological; Adrenal Cortex; Aging; Animals; Atrophy; Brain Ischemia; Chronic Disease; Circadian Rhythm; Dendrites; Dentate Gyrus; Depression; Estrogens; Female; Glucocorticoids; Glutamic Acid; Hippocampus; Humans; Hypothalamo-Hypophyseal System; Male; Memory Disorders; Models, Animal; Neuralgia; Neurons; Pain; Pituitary-Adrenal System; Rats; Restraint, Physical; Seizures; Stress Disorders, Post-Traumatic; Stress, Physiological; Tumor Necrosis Factor-alpha | 2001 |
17 trial(s) available for glutamic acid and Ache
| Article | Year |
|---|---|
Combining microdialysis and near-infrared spectroscopy for studying effects of low-load repetitive work on the intramuscular chemistry in trapezius myalgia.
Topics: Adiposity; Adult; Female; Glutamic Acid; Humans; Lactic Acid; Microdialysis; Muscle, Skeletal; Muscular Diseases; Oxygen; Pain; Physical Exertion; Spectroscopy, Near-Infrared; Weight-Bearing | 2010 |
Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain.
Topics: Adult; Analgesia; Aspartic Acid; Brain; Chronic Disease; Female; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pain; Pain Management; Pancreatitis, Chronic; Radionuclide Imaging; Severity of Illness Index; Somatosensory Cortex; Transcranial Magnetic Stimulation; Treatment Outcome | 2011 |
Comparison of glutamate-evoked pain between the temporalis and masseter muscles in men and women.
Topics: Adult; Double-Blind Method; Female; Glutamic Acid; Humans; Injections, Intramuscular; Male; Masseter Muscle; Pain; Pain Measurement; Pilot Projects; Sex Characteristics; Temporal Muscle; Young Adult | 2012 |
Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up.
Topics: Brain; Clinical Protocols; Cognition; Double-Blind Method; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Fibromyalgia; Glutamic Acid; Health Status; Humans; Magnetic Resonance Spectroscopy; Memantine; Pain; Pain Measurement; Pain Perception; Pain Threshold; Quality of Life; Research Design; Spain; Time Factors; Treatment Outcome | 2013 |
Release of algesic substances in human experimental muscle pain.
Topics: Adult; Arm; Dinoprostone; Exercise; Female; Glutamic Acid; Humans; Hypertonic Solutions; Inflammation; Lactic Acid; Leg; Male; Microdialysis; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Nitric Oxide; Pain; Pain Measurement; Sodium Chloride; Substance P; Time Factors | 2002 |
Glutamate evoked neck and jaw muscle pain facilitate the human jaw stretch reflex.
Topics: Adult; Electromyography; Glutamic Acid; Humans; Jaw; Male; Masticatory Muscles; Pain; Reflex, Stretch; Trigeminal Nerve | 2004 |
Gender differences in pain modulation evoked by repeated injections of glutamate into the human trapezius muscle.
Topics: Adult; Analysis of Variance; Area Under Curve; Drug Administration Schedule; Female; Glutamic Acid; Humans; Injections, Intramuscular; Male; Neck Muscles; Pain; Pain Measurement; Pain Threshold; Sex Characteristics; Time Factors | 2005 |
Pain effects of glutamate injections into human jaw or neck muscles.
Topics: Adult; Analysis of Variance; Glutamic Acid; Humans; Injections, Intramuscular; Isotonic Solutions; Male; Masseter Muscle; Neck Muscles; Noxae; Pain; Pain Measurement; Pain Threshold; Pressure; Single-Blind Method; Time Factors | 2005 |
A novel technique to study the brain's response to pain: proton magnetic resonance spectroscopy.
Topics: Adult; Brain; Brain Chemistry; Cold Temperature; Female; Glutamic Acid; Glutamine; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Pain; Pain Measurement; Pressure; Protons; Synaptic Transmission | 2005 |
Chemomechanical caries removal for children.
Topics: Anesthesia, Dental; Child; Child, Preschool; Dental Care for Children; Dental Caries; Dental Cavity Preparation; Dental Instruments; Dental Restoration, Permanent; Dentition, Permanent; DMF Index; Glutamic Acid; Humans; Leucine; Lysine; Pain; Tooth, Deciduous; Treatment Outcome | 2005 |
Clinical randomized controlled trial of chemomechanical caries removal (Carisolv).
Topics: Anesthesia, Local; Child; Child Behavior; Cross-Over Studies; Dental Caries; Dental Cavity Preparation; Dental High-Speed Equipment; Female; Glutamic Acid; Humans; Leucine; Lysine; Male; Molar; Pain; Patient Satisfaction; Time Factors; Tooth, Deciduous; Treatment Outcome | 2006 |
Effects of subcutaneous administration of glutamate on pain, sensitization and vasomotor responses in healthy men and women.
Topics: Adult; Female; Forehead; Glutamic Acid; Humans; Hyperalgesia; Injections, Subcutaneous; Male; Pain; Pain Threshold; Regional Blood Flow; Sex Characteristics; Skin; Skin Temperature; Sodium Chloride | 2006 |
Effect of low-level clenching and subsequent muscle pain on exteroceptive suppression and resting muscle activity in human jaw muscles.
Topics: Adult; Electric Stimulation; Electromyography; Feedback; Female; Fingers; Glutamic Acid; Humans; Injections, Intramuscular; Isometric Contraction; Male; Masseter Muscle; Masticatory Muscles; Muscle Fatigue; Nociceptors; Pain; Pain Measurement; Pressure; Sodium Chloride | 2007 |
Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women.
Topics: Adult; Analgesics; Analysis of Variance; Contraceptives, Oral; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Ketamine; Masseter Muscle; Pain; Pain Measurement; Receptors, N-Methyl-D-Aspartate | 2007 |
Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia.
Topics: Acupuncture Therapy; Adult; Biomarkers; Cerebral Cortex; Female; Fibromyalgia; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Middle Aged; Pain; Pain Management; Severity of Illness Index; Single-Blind Method | 2008 |
In situ microdialysis in tendon tissue: high levels of glutamate, but not prostaglandin E2 in chronic Achilles tendon pain.
Topics: Achilles Tendon; Adult; Analysis of Variance; Chronic Disease; Dinoprostone; Glutamic Acid; Humans; Male; Microdialysis; Middle Aged; Pain; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Tendinopathy | 1999 |
Sex-related differences in human pain and rat afferent discharge evoked by injection of glutamate into the masseter muscle.
Topics: Adult; Animals; Female; Glutamic Acid; Humans; Male; Masseter Muscle; Neural Conduction; Neurons, Afferent; Pain; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stimulation, Chemical | 2001 |
316 other study(ies) available for glutamic acid and Ache
| Article | Year |
|---|---|
Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain.
Topics: Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred ICR; Pain; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Spinal Cord; TRPV Cation Channels | 2021 |
Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Gene Expression Regulation; Glutamic Acid; Hot Temperature; Humans; Male; Mice; Pain; Pyrans | 2022 |
Music alleviates pain perception in depression mouse models by promoting the release of glutamate in the hippocampus of mice to act on GRIK5.
Topics: Animals; Depression; Glutamic Acid; Hippocampus; Mice; Music; N-Methylaspartate; Pain; Pain Perception; Serotonin | 2022 |
Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain.
Topics: Animals; Basolateral Nuclear Complex; Cerebral Cortex; Glutamic Acid; Insular Cortex; Mice; Pain; Synapses | 2022 |
Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine.
Topics: Central Nervous System Sensitization; Female; Glutamic Acid; Headache; Humans; Migraine Disorders; Pain | 2022 |
A Possible Mechanism for Development of Working Memory Impairment in Male Mice Subjected to Inflammatory Pain.
Topics: Amino Acid Transport System X-AG; Animals; Female; Freund's Adjuvant; Glutamic Acid; Inflammation; Male; Memory Disorders; Memory, Short-Term; Mice; Pain | 2022 |
Influence of Inflammatory Pain and Dopamine on Synaptic Transmission in the Mouse ACC.
Topics: Animals; Dopamine; Glutamic Acid; Gyrus Cinguli; Inflammation; Mice; Pain; Synaptic Transmission | 2023 |
Assessment of temporomandibular disorders and their relationship with life quality and salivary biomarkers in patients with dentofacial deformities: A clinical observational study.
Topics: Biomarkers; Dentofacial Deformities; Glutamic Acid; Humans; Pain; Quality of Life; Serotonin; Temporomandibular Joint Disorders | 2023 |
Modulation of COX-2, INF-ɣ, glutamatergic and opioid systems contributes to antinociceptive, anti-inflammatory and anti-hyperalgesic effects of bis(3-amino-2-pyridine) diselenide.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Edema; Exploratory Behavior; Foot; Gene Expression Regulation; Glutamic Acid; Interferon-gamma; Liver; Locomotion; Male; Mice; Nociception; Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Toxicity Tests, Acute; Tumor Necrosis Factor-alpha | 2019 |
Decreased Glutamatergic Synaptic Strength in the Periaqueductal Gray Contributes to Maintenance of Visceral Pain in Male Rats with Experimental Pancreatitis.
Topics: Animals; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Pain; Pain Measurement; Pancreatitis; Periaqueductal Gray; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission | 2020 |
Daytime changes of salivary biomarkers involved in pain.
Topics: Biomarkers; Glutamic Acid; Humans; Pain; Saliva; Substance P; Young Adult | 2020 |
Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord.
Topics: Animals; Formaldehyde; Glutamic Acid; Male; Nefopam; Norepinephrine; Pain; Serotonin; Serotonin Antagonists; Spinal Cord; Synaptic Transmission | 2020 |
A capital role for the brain's insula in the diverse fibromyalgia-associated symptoms.
Topics: Cerebral Cortex; Fibromyalgia; Glutamic Acid; Humans; Pain; Sleep Wake Disorders | 2020 |
Dysregulation of EAAT2 and VGLUT2 Spinal Glutamate Transports via Histone Deacetylase 2 (HDAC2) Contributes to Paclitaxel-induced Painful Neuropathy.
Topics: Animals; Excitatory Amino Acid Transporter 2; Glutamic Acid; Histone Deacetylase 2; Male; Paclitaxel; Pain; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Vesicular Glutamate Transport Protein 2 | 2020 |
D1 receptors in the anterior cingulate cortex modulate basal mechanical sensitivity threshold and glutamatergic synaptic transmission.
Topics: Animals; Behavior, Animal; Benzazepines; CRISPR-Cas Systems; Excitatory Postsynaptic Potentials; Gene Knockout Techniques; Glutamic Acid; Gyrus Cinguli; Ion Channel Gating; Male; Mice, Inbred C57BL; Pain; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Sensory Thresholds; Synaptic Transmission | 2020 |
Additional considerations for studying brain metabolite levels across pain conditions using proton magnetic resonance spectroscopy.
Topics: Brain; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Pain; Proton Magnetic Resonance Spectroscopy | 2021 |
Metabolite activity in the anterior cingulate cortex during a painful stimulus using functional MRS.
Topics: Adult; Female; Functional Neuroimaging; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Pain; Young Adult | 2020 |
CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals.
Topics: Animals; Benzoxazines; Calcitonin Gene-Related Peptide; Calcium Signaling; Chemokine CCL2; Ganglia, Spinal; Glutamic Acid; Hyperalgesia; Inflammation; Injections, Spinal; Mice, Inbred C57BL; Neurons; Nociceptors; Pain; Presynaptic Terminals; Protein Binding; Receptors, CCR2; Spinal Cord; Spinal Cord Dorsal Horn; Spiro Compounds; Synaptic Transmission; Up-Regulation | 2020 |
An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice.
Topics: Analgesics, Opioid; Animals; Animals, Genetically Modified; Behavior, Animal; Calcium Signaling; Disease Models, Animal; Drug Tolerance; Female; GABAergic Neurons; Glutamic Acid; Hypothalamic Area, Lateral; Male; Mice, Inbred C57BL; Microscopy, Fluorescence; Morphine; Neural Pathways; Neuroanatomical Tract-Tracing Techniques; Nociception; Optogenetics; Pain; Parvalbumins | 2021 |
Antinociceptive effect of the hydroethanolic leaf extract of Calotropis procera (Ait) R. Br. (Apocynaceae): Possible involvement of glutamatergic, cytokines, opioidergic and adenosinergic pathways.
Topics: Adenosine; Analgesics; Analgesics, Opioid; Animals; Calotropis; Dose-Response Relationship, Drug; Ghana; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Pain Threshold; Plant Extracts; Plant Leaves | 2021 |
The translocator protein gene is associated with endogenous pain modulation and the balance between glutamate and γ-aminobutyric acid in fibromyalgia and healthy subjects: a multimodal neuroimaging study.
Topics: Brain; Fibromyalgia; gamma-Aminobutyric Acid; Glutamic Acid; Healthy Volunteers; Humans; Neuroimaging; Pain; Positron-Emission Tomography; Receptors, GABA | 2022 |
Sex-related differences in response to masseteric injections of glutamate and nerve growth factor in healthy human participants.
Topics: Adult; Biomarkers; Connective Tissue; Female; Glutamic Acid; Healthy Volunteers; Humans; Injections; Male; Masseter Muscle; Mastication; Muscle Cells; Nerve Fibers; Nerve Growth Factor; Pain; Pain Threshold; Pressure; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Substance P; Time Factors | 2021 |
A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA.
Topics: Analgesics; Animals; Disease Models, Animal; Dopamine beta-Hydroxylase; Excitatory Amino Acid Agents; Formaldehyde; Glutamate Carboxypeptidase II; Glutamic Acid; Locus Coeruleus; Male; Norepinephrine; Organophosphorus Compounds; Pain; Rats; Rats, Sprague-Dawley; Urea | 2017 |
Hydro-ethanolic leaf extract of Ziziphus abyssinica Hochst Ex A. Rich (Rhamnaceae) exhibits anti-nociceptive effects in murine models.
Topics: Acetic Acid; Africa; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Inflammation; Male; Mice, Inbred ICR; Nociceptive Pain; Pain; Phytotherapy; Plant Extracts; Plant Leaves; Rats, Sprague-Dawley; Reaction Time; Ziziphus | 2017 |
Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity.
Topics: Acetanilides; Animals; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Glutamic Acid; Glycine; Hyperalgesia; Male; Neurons; Pain; Pain Threshold; Phenylacetates; Physical Stimulation; Purines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Signal Transduction; Skin; Thiazoles; Trigeminal Ganglion; TRPA1 Cation Channel; TRPV Cation Channels | 2017 |
[Analgesic effect and central mechanisms of CQ prescription on cancer invasion induced mirror image pain in model mice].
Topics: Analgesics; Animals; Drugs, Chinese Herbal; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Neoplasms, Experimental; Pain; Spinal Cord; Taurine | 2017 |
Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Formaldehyde; Glutamic Acid; Injections, Intraventricular; Injections, Spinal; Male; Mice, Inbred ICR; Nociception; Oxyntomodulin; Pain; Rotarod Performance Test; Spinal Cord; Substance P | 2018 |
Saliva as a medium to detect and measure biomarkers related to pain.
Topics: Adult; Biomarkers; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Female; Gene Expression; Glutamic Acid; Healthy Volunteers; Humans; Luminescence; Male; Nerve Growth Factor; Pain; Plasma; Saliva; Specimen Handling; Substance P; Young Adult | 2018 |
Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats.
Topics: Animals; Benzhydryl Compounds; Benzoxazoles; Corpus Striatum; Glutamic Acid; Hyperalgesia; Lidocaine; Male; Medulla Oblongata; Microinjections; Neuralgia; Neurons; Neuroprotective Agents; Pain; Rats; Receptors, Metabotropic Glutamate; Reticular Formation; Sciatic Nerve; Subthalamic Nucleus | 2018 |
Involvement of the periaqueductal gray in the descending antinociceptive effect induced by the central nucleus of amygdala.
Topics: Animals; Central Amygdaloid Nucleus; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Nerve Net; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Piperidines; Pyrazoles; Serotonin | 2018 |
Effects of isopulegol in acute nociception in mice: Possible involvement of muscarinic receptors, opioid system and l-arginine/NO/cGMP pathway.
Topics: Acute Disease; Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Cyclic GMP; Cyclohexane Monoterpenes; Female; Formaldehyde; Glutamic Acid; Male; Mice; Nitric Oxide; Pain; Receptors, Muscarinic; Receptors, Opioid; Signal Transduction; Terpenes | 2018 |
Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV₁, Glutamate, and Opioid Receptors.
Topics: Administration, Oral; Analgesics; Animals; Chalcones; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Injections, Intraperitoneal; Mice; Pain; Plant Extracts; Receptors, Opioid; TRPV Cation Channels; Zingiberaceae | 2018 |
Synthesis and Pharmacological Evaluation of Novel Selenoethers Glycerol Derivatives for the Treatment of Pain and Inflammation: Involvement of Nitrergic and Glutamatergic Systems.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chemistry Techniques, Synthetic; Ethers; Glutamic Acid; Glycerol; Inflammation; Male; Mice; Nitric Oxide; Pain; Selenium | 2019 |
Repetitive neonatal pain and reduced maternal care alter brain neurochemistry.
Topics: Animals; Corticosterone; Disease Models, Animal; Female; Frontal Lobe; Glutamic Acid; Hippocampus; Intensive Care Units, Neonatal; Magnetic Resonance Spectroscopy; Male; Maternal Deprivation; Pain; Rats; Rats, Sprague-Dawley | 2018 |
Interleukin-1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel-associated acute pain syndrome.
Topics: Animals; Antineoplastic Agents; Calcium; Excitatory Postsynaptic Potentials; Glutamic Acid; Interleukin-1beta; Male; Mice; Mice, Knockout; Microglia; Miniature Postsynaptic Potentials; Paclitaxel; Pain; Pain Measurement; Rats; Spinal Cord Dorsal Horn | 2019 |
The glutamate to γ-aminobutyric acid ratio in the posterior insula is associated with pain perception in healthy women but not in women with borderline personality disorder.
Topics: Adolescent; Adult; Borderline Personality Disorder; Brain Mapping; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Middle Aged; Pain; Pain Perception; Pain Threshold; Women's Health; Young Adult | 2019 |
Evaluation of mechanisms involved in the antinociception of the ethanol extract from the inner bark of Caesalpinia pyramidalis in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Behavior, Animal; Caesalpinia; Capsaicin; Ethanol; Female; Glutamic Acid; Male; Mice; Nitric Oxide; Pain; Phytotherapy; Plant Bark; Plant Extracts; Solvents | 2013 |
Intrathecal glutamate release during hindlimb tourniquet inflation and femoral artery occlusion in rats.
Topics: Animals; Arterial Occlusive Diseases; Femoral Artery; Glutamic Acid; Hindlimb; Male; Microdialysis; Pain; Rats; Rats, Wistar; Spinal Cord; Tourniquets | 2013 |
Antinociceptive profiles and mechanisms of orally administered coumarin in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Coumarins; Formaldehyde; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Pain; Receptors, Opioid; Substance P | 2013 |
Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bone and Bones; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Humans; Mice; Mice, Nude; Pain; Pain Measurement; Sulfasalazine; Survival Analysis; Xenograft Model Antitumor Assays | 2014 |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antiviral Agents; Chlorocebus aethiops; Formaldehyde; Glutamic Acid; Herpesvirus 1, Human; Herpesvirus 2, Human; Mice; Pain; Phytolaccaceae; Plant Extracts; Plant Leaves; Plant Roots; Vero Cells | 2013 |
Glutamate/GABA balance in ACC modulates the nociceptive responses of vocalization: an expression of affective-motivational component of pain in guinea pigs.
Topics: Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Gyrus Cinguli; Homocysteine; Male; Microinjections; Muscimol; Pain; Time Factors; Vocalization, Animal | 2014 |
Antioxidant and orofacial anti-nociceptive activities of the stem bark aqueous extract of Anadenanthera colubrina (Velloso) Brenan (Fabaceae).
Topics: Amidines; Analgesics; Animals; Antioxidants; Biphenyl Compounds; Capsaicin; Colubrina; Fabaceae; Glutamic Acid; Lipid Peroxidation; Male; Mice; Pain; Pain Measurement; Phytotherapy; Picrates; Plant Bark; Plant Extracts; Plant Stems | 2014 |
Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Dextrans; Edema; Formaldehyde; Glutamic Acid; Histamine; Inflammation; Male; Mice; Naloxone; Pain; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Rats, Wistar; Sterculia | 2014 |
Antinociceptive esters of N-methylanthranilic acid: Mechanism of action in heat-mediated pain.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; KATP Channels; Male; Mice; Motor Activity; Narcotic Antagonists; Neurotransmitter Agents; ortho-Aminobenzoates; Pain; Pain Perception; Pain Threshold; Potassium Channel Blockers; Reaction Time; Time Factors | 2014 |
[Analgesic effect of CQM on prosopalgia model rats and its impact on exciting amino acid neurotransmitters].
Topics: Animals; Drugs, Chinese Herbal; Glutamic Acid; Humans; Male; Neurotransmitter Agents; Pain; Rats; Rats, Sprague-Dawley; Trigeminal Nerve Diseases | 2013 |
Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica.
Topics: Acetic Acid; Anacardiaceae; Analgesics; Animals; Cyclic GMP; Ethanol; Female; Formaldehyde; Glutamic Acid; Glyburide; Hot Temperature; KATP Channels; Male; Methylene Blue; Mice; Pain; Phytotherapy; Plant Extracts; Plant Leaves; Solvents; Toxicity Tests, Acute | 2014 |
Descending effect on spinal nociception by amygdaloid glutamate varies with the submodality of noxious test stimulation.
Topics: Animals; Central Amygdaloid Nucleus; Dominance, Cerebral; Glutamic Acid; Male; Nociception; Pain; Pain Measurement; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Rotarod Performance Test; Spinal Cord | 2014 |
Higher glutamate+glutamine and reduction of N-acetylaspartate in posterior cingulate according to age range in patients with cognitive impairment and/or pain.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspartic Acid; Case-Control Studies; Cognition Disorders; Creatine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Pain; Prospective Studies | 2014 |
Uliginosin B, a natural phloroglucinol derivative, presents a multimediated antinociceptive effect in mice.
Topics: Analgesics; Animals; Behavior, Animal; Biogenic Monoamines; Glutamic Acid; Hypericum; Male; Mice, Inbred Strains; Pain; Pain Measurement; Pain Threshold; Phloroglucinol; Plant Components, Aerial; Plant Extracts; Synaptic Transmission | 2014 |
Serotonergic systems are implicated in antinociceptive effect of m-trifluoromethyl diphenyl diselenide in the mouse glutamate test.
Topics: Analgesics; Animals; Female; Glutamic Acid; Mice; Organosilicon Compounds; Pain; Pain Measurement; Selenium; Serotonergic Neurons; Serotonin; Synaptosomes; Tissue Distribution | 2014 |
Antinociceptive, anti-inflammatory and gastroprotective effects of a hydroalcoholic extract from the leaves of Eugenia punicifolia (Kunth) DC. in rodents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Eugenia; Female; Glutamic Acid; Inflammation; Male; Medicine, Traditional; Mice; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Rats; Rats, Wistar | 2014 |
[Cardioprotective properties of new glutamic acid derivative under stress conditions].
Topics: Animals; Animals, Outbred Strains; Cardiotonic Agents; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamic Acid; Heart; Heart Rate; Immobilization; Male; Myocardial Contraction; Pain; Rats; Stress, Physiological | 2014 |
Inflammatory pain models with capsaicin or glutamate injections: are they comparable and reproducible?
Topics: Capsaicin; Glutamic Acid; Humans; Inflammation; Pain; Reproducibility of Results | 2014 |
Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice.
Topics: Acetic Acid; Analgesics; Animals; Ethanol; Female; Formaldehyde; Glutamic Acid; Hedyotis; Hot Temperature; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Phytotherapy; Plant Extracts; Receptors, Opioid; Solvents | 2015 |
Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Bone and Bones; Breast Neoplasms; Capsaicin; Cell Line, Tumor; Dopamine Agonists; Drug Discovery; Female; Glutamic Acid; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Pain; Signal Transduction; Small Molecule Libraries | 2015 |
Antinociceptive action of diphenyl diselenide in the nociception induced by neonatal administration of monosodium glutamate in rats.
Topics: Analgesics; Animals; Animals, Newborn; Benzene Derivatives; Calcium-Transporting ATPases; Cytokines; Glutamic Acid; Hippocampus; Motor Activity; Organoselenium Compounds; Pain; Pain Measurement; Rats; Sodium Glutamate; Sodium-Potassium-Exchanging ATPase | 2015 |
Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice.
Topics: Acetic Acid; Acrolein; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Bangladesh; Behavior, Animal; Formaldehyde; Glutamic Acid; Male; Medicine, Traditional; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Plant Leaves; Polygonum | 2015 |
Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Carrageenan; Cell Movement; Edema; Female; Formaldehyde; Glutamic Acid; Isoflavones; Leukocytes; Male; Mice; Pain; Peritonitis; Propolis; Rats, Wistar | 2015 |
Pharmacological evidence favouring the traditional use of the root bark of Condalia buxifolia Reissek in the relief of pain and inflammation in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Edema; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Medicine, Traditional; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Phytotherapy; Plant Extracts; Plant Roots; Rhamnaceae | 2015 |
Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats.
Topics: Analgesia; Animals; Astrocytes; Capsaicin; Down-Regulation; Excitatory Amino Acid Transporter 2; Gene Knockdown Techniques; Glutamic Acid; Locus Coeruleus; Male; Neurons; Norepinephrine; Pain; Pain Threshold; Rats, Sprague-Dawley; RNA, Small Interfering; Spinal Cord | 2015 |
Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways.
Topics: Animals; Arthritis; Behavior, Animal; Disease Models, Animal; Electrophysiology; Galanin; Glutamic Acid; Hyperalgesia; Hypothalamus; Lidocaine; Male; Mediodorsal Thalamic Nucleus; Neurons; Nociception; Ondansetron; Pain; Pressure; Protein Precursors; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Serotonin; Spinal Cord | 2015 |
Involvement of spinal glutamate in nociceptive behavior induced by intrathecal administration of hemokinin-1 in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Glutamic Acid; Injections, Spinal; Male; Mice; Nociception; Pain; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tachykinins | 2016 |
Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn.
Topics: Acetic Acid; Analgesics; Animals; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Phytotherapy; Plant Extracts; Plant Leaves; Receptors, Opioid; Stephania | 2016 |
Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice.
Topics: Acetic Acid; Analgesics; Animals; Artemia; Capsaicin; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Larva; Lethal Dose 50; Male; Methanol; Mice; Motor Activity; Pain; Phytochemicals; Phytotherapy; Plant Extracts; Plant Leaves; Rosales; Rotarod Performance Test; Solvents; Water | 2016 |
The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Bone Density Conservation Agents; Capsaicin; Clodronic Acid; Etidronic Acid; Excitatory Amino Acid Agonists; Foscarnet; Glutamic Acid; Lumbar Vertebrae; Mice; Mice, Inbred BALB C; N-Methylaspartate; Pain; Sodium-Phosphate Cotransporter Proteins; Spinal Cord; Substance P | 2016 |
Combined glutamate and glutamine levels in pain-processing brain regions are associated with individual pain sensitivity.
Topics: Adult; Brain; Brain Mapping; Cross-Sectional Studies; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Pain; Pain Threshold; Protons; Young Adult | 2016 |
Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels.
Topics: Acetanilides; Amides; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Excitatory Postsynaptic Potentials; Glutamic Acid; Levobupivacaine; Male; Neurotransmitter Agents; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Prilocaine; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Ropivacaine; Ruthenium Red; Substantia Gelatinosa; Tetracaine; Tetrodotoxin; Tissue Culture Techniques; TRPA1 Cation Channel; TRPC Cation Channels | 2017 |
Spinal intracellular metabotropic glutamate receptor 5 (mGluR5) contributes to pain and c-fos expression in a rat model of inflammatory pain.
Topics: Animals; Cadherins; Conditioning, Operant; Cyclodextrins; Disease Models, Animal; Excitatory Amino Acid Transporter 4; Freund's Adjuvant; Glutamic Acid; Histone Deacetylase 1; Inflammation; Intracellular Space; Male; Microdialysis; Pain; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Long-Evans; Receptor, Metabotropic Glutamate 5; Spinal Cord | 2017 |
Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice.
Topics: Acetic Acid; Analgesics; Animals; Cyclic GMP; Dalbergia; Disease Models, Animal; Drug Evaluation, Preclinical; Formaldehyde; Glutamic Acid; KATP Channels; Mice; Pain; Phytotherapy; Plant Extracts; Random Allocation; Signal Transduction | 2017 |
Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition.
Topics: Analgesia; Animals; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Neurons; Oxytocin; Pain; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Spinal Cord | 2008 |
Quercetin: further investigation of its antinociceptive properties and mechanisms of action.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cholinergic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; GABA Agents; Glutamic Acid; Hot Temperature; Male; Mice; Motor Activity; Nitric Oxide Synthase; Pain; Pain Measurement; Pain Threshold; Quercetin; Reaction Time; Serotonin Antagonists; Signal Transduction | 2008 |
Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli.
Topics: Acetic Acid; Analysis of Variance; Animals; Behavior, Animal; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Formaldehyde; Gene Expression Regulation, Enzymologic; Glutamic Acid; Hippocampus; Interleukin-1beta; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Phosphorylation; Protein Kinase Inhibitors; Sulfonamides; Time Factors; Tumor Necrosis Factor-alpha | 2008 |
Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex.
Topics: Animals; Cyclic AMP; Glutamic Acid; Gyrus Cinguli; Inflammation; Male; Mice; Mice, Transgenic; Neurons; Octopamine; Pain; Presynaptic Terminals; Synaptic Transmission | 2008 |
Further analysis of the antinociceptive action caused by p-methoxyl-diphenyl diselenide in mice.
Topics: Analgesics; Animals; Arginine; Benzazepines; Benzene Derivatives; Bradykinin; Dopamine Antagonists; Enzyme Inhibitors; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Mice; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Organoselenium Compounds; Pain; Receptors, Neurotransmitter; Tetradecanoylphorbol Acetate | 2009 |
Redox modulation at the peripheral site alters nociceptive transmission in vivo.
Topics: Alkylating Agents; Analgesics; Animals; Azoles; Behavior, Animal; Buthionine Sulfoximine; Disease Models, Animal; Dithiothreitol; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glutamate-Cysteine Ligase; Glutamic Acid; Glutathione; Iodoacetates; Isoindoles; Mice; Organoselenium Compounds; Oxidation-Reduction; Pain; Receptors, N-Methyl-D-Aspartate; Reducing Agents; Signal Transduction; Sulfhydryl Compounds | 2009 |
Inhibition of the ubiquitin-proteasome activity prevents glutamate transporter degradation and morphine tolerance.
Topics: Analgesics, Opioid; Animals; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Tolerance; Glutamic Acid; Injections, Spinal; Leupeptins; Male; Morphine; Pain; Posterior Horn Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Spinal Cord; Treatment Outcome; Ubiquitin; Vesicular Glutamate Transport Proteins | 2008 |
Contralateral high or a combination of high- and low-frequency transcutaneous electrical nerve stimulation reduces mechanical allodynia and alters dorsal horn neurotransmitter content in neuropathic rats.
Topics: Acupuncture Points; Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neurotransmitter Agents; Pain; Pain Management; Pain Measurement; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Skin; Spinal Cord; Transcutaneous Electric Nerve Stimulation | 2009 |
Large projection neurons in lamina I of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors.
Topics: Animals; Carrier Proteins; Cell Shape; Dendrites; Glutamic Acid; Immunohistochemistry; Interneurons; Male; Membrane Proteins; Nociceptors; Pain; Physical Stimulation; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Neurokinin-1; Spinothalamic Tracts; Substance P; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2008 |
Enhanced pronociception by amygdaloid group I metabotropic glutamate receptors in nerve-injured animals.
Topics: Action Potentials; Amygdala; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Medulla Oblongata; Neural Pathways; Nociceptors; Pain; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reticular Formation; Synapses; Up-Regulation | 2009 |
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Allopurinol; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrimidines; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines | 2009 |
Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue.
Topics: Adult; Analysis of Variance; Capsaicin; Drug Interactions; Glutamic Acid; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Tendons; Young Adult | 2009 |
Algesic agents exciting muscle nociceptors.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Capsaicin; Glutamic Acid; Hydrogen-Ion Concentration; Interleukins; Muscles; Nerve Growth Factor; Nociceptors; Pain; Potassium Chloride; Prostaglandins; Protons; Rats; Serotonin; Sodium Chloride | 2009 |
Evaluation of sympathetic vasoconstrictor response following nociceptive stimulation of latent myofascial trigger points in humans.
Topics: Adult; Female; Forearm; Glutamic Acid; Humans; Injections, Intramuscular; Male; Myofascial Pain Syndromes; Pain; Pain Threshold; Regional Blood Flow; Respiration; Skin Temperature; Stimulation, Chemical; Sympathetic Nervous System; Vasoconstriction | 2009 |
Transient receptor potential vanilloid type 1 receptor regulates glutamatergic synaptic inputs to the spinothalamic tract neurons of the spinal cord deep dorsal horn.
Topics: Animals; Calcium Channels; Capsaicin; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Miniature Postsynaptic Potentials; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sensory System Agents; Spinothalamic Tracts; Statistics, Nonparametric; Synaptic Transmission; TRPV Cation Channels | 2009 |
Attenuated skin blood flow response to nociceptive stimulation of latent myofascial trigger points.
Topics: Adult; Female; Glutamic Acid; Humans; Male; Myofascial Pain Syndromes; Pain; Pain Measurement; Pain Threshold; Skin; Skin Temperature; Stimulation, Chemical | 2009 |
[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain].
Topics: Acute Disease; Amino Acids; Analgesics, Opioid; Animals; Arginine; Aspartic Acid; Cerebral Cortex; Disinfectants; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Male; Microdialysis; Morphine; Pain; Rats; Rats, Wistar | 2008 |
Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Cinnamates; Depsides; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Male; Mecamylamine; Melissa; Mice; Motor Activity; Naloxone; Nitric Oxide; Pain; Pain Threshold; Phytotherapy; Plant Extracts; Plant Leaves; Receptors, Muscarinic; Receptors, Nicotinic; Rosmarinic Acid | 2009 |
Filicene obtained from Adiantum cuneatum interacts with the cholinergic, dopaminergic, glutamatergic, GABAergic, and tachykinergic systems to exert antinociceptive effect in mice.
Topics: Acetic Acid; Adiantum; Analgesics; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Male; Mice; Molecular Structure; Pain; Phytotherapy; Plants, Medicinal; Receptors, Cholinergic; Receptors, Dopamine; Receptors, GABA; Receptors, Neurotransmitter; Receptors, Tachykinin; Triterpenes | 2009 |
Spinal mechanisms of antinociceptive action caused by guanosine in mice.
Topics: Analgesics; Animals; Behavior, Animal; Biological Transport; Glutamic Acid; Guanosine; Injections, Spinal; Male; Mice; Neurochemistry; Pain; Purines; Spine | 2009 |
Increased glutamate and decreased glycine release in the rostral ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain.
Topics: Acids; Analysis of Variance; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Glutamic Acid; Glycine; Male; Medulla Oblongata; Microdialysis; Muscle, Skeletal; Pain; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sodium Chloride | 2009 |
Involvement of glutamate and cytokine pathways on antinociceptive effect of Pfaffia glomerata in mice.
Topics: Acetic Acid; Amaranthaceae; Analgesics; Animals; Behavior, Animal; Cycloleucine; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Injections, Spinal; Interleukin-1beta; Mice; Naloxone; Narcotic Antagonists; Pain; Phytotherapy; Plant Extracts; Plant Roots; Tumor Necrosis Factor-alpha | 2009 |
Endogenous opiate peptides in the spinal cord are involved in the analgesia of hypothalamic paraventricular nucleus in the rat.
Topics: Analgesia; Animals; Glutamic Acid; Male; Microinjections; Naloxone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Measurement; Paraventricular Hypothalamic Nucleus; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spinal Cord | 2009 |
Substance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Indoles; Inflammation; Male; Maleimides; Medulla Oblongata; Neural Pathways; Neurons; Neurotransmitter Agents; Pain; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Serotonin; Substance P; Sulfonamides; Synaptic Transmission | 2009 |
Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the nucleus raphe magnus to participate in pain modulation.
Topics: Animals; Arginine Vasopressin; Biological Transport; Cautery; Glutamic Acid; Male; Pain; Paraventricular Hypothalamic Nucleus; Perfusion; Raphe Nuclei; Rats; Rats, Sprague-Dawley | 2009 |
Arginine vasopressin antinociception in the rat nucleus raphe magnus is involved in the endogenous opiate peptide and serotonin system.
Topics: Analgesics; Animals; Arginine Vasopressin; Choline; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Glutamic Acid; Indoles; Male; Opioid Peptides; Oxytocin; Pain; Pain Measurement; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin | 2009 |
Early and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cells, Cultured; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Ganglia, Spinal; Glutamic Acid; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, N-Methyl-D-Aspartate; Sensory Receptor Cells; Time Factors | 2009 |
Antinociceptive activity of a new benzofuranone derived from a chalcone.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzofurans; Capsaicin; Chalcone; Dose-Response Relationship, Drug; Formaldehyde; Glutamic Acid; Linear Models; Male; Mice; Nociception; Pain; Pain Measurement | 2009 |
Glutamate modulation of antinociception, but not tolerance, produced by morphine microinjection into the periaqueductal gray of the rat.
Topics: Analgesia; Analgesics, Opioid; Analysis of Variance; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Glutamic Acid; Hot Temperature; Kynurenic Acid; Male; Microinjections; Morphine; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Opioid, mu; Staining and Labeling | 2009 |
Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation.
Topics: Acute Disease; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Glutamic Acid; Hot Temperature; Humans; Magnetic Resonance Spectroscopy; Male; Pain; Periodicity; Physical Stimulation; Protons; Time Factors | 2010 |
Elevated insular glutamate in fibromyalgia is associated with experimental pain.
Topics: Adult; Case-Control Studies; Cerebral Cortex; Female; Fibromyalgia; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Pain; Pain Threshold | 2009 |
Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Gene Expression Regulation; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Fibers, Myelinated; Neurons; Neuropeptides; Pain; Pain Measurement; Piperidines; Receptor, Parathyroid Hormone, Type 2; Reflex; Sciatica; Signal Transduction; Time Factors; TRPV Cation Channels | 2010 |
Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Insulin; Mice; Organ Culture Techniques; Pain; Patch-Clamp Techniques; Phenols; Posterior Horn Cells; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, AMPA; Sensory Receptor Cells; Signal Transduction; Synaptic Transmission | 2010 |
Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Cells, Cultured; Central Nervous System Agents; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Glutamic Acid; In Vitro Techniques; Locus Coeruleus; Male; Neural Inhibition; Neural Pathways; Neurons; Pain; Phosphorylation; Random Allocation; Rats; Rats, Sprague-Dawley; Riluzole; Spinal Nerves | 2010 |
Local effects of octreotide on glutamate-evoked activation of Adelta and C afferent fibers in rat hairy skin.
Topics: Action Potentials; Animals; Drug Interactions; Electrophysiology; Glutamic Acid; Hair Follicle; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Inhibition; Nociceptors; Octreotide; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Somatostatin; Sensory Receptor Cells; Skin; Somatostatin | 2010 |
N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system.
Topics: Administration, Oral; Analgesics; Animals; Antipyrine; Behavior, Animal; Carrageenan; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Pain; Pain Measurement; Pain Threshold; Reaction Time; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Signal Transduction; Time Factors | 2010 |
Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Ethanol; Female; Formaldehyde; Glutamic Acid; Locomotion; Male; Mice; Morphine; Pain; Pentacyclic Triterpenes; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Zanthoxylum | 2010 |
The nociception induced by glutamate in mice is potentiated by protons released into the solution.
Topics: Acetic Acid; Acid Sensing Ion Channels; Animals; Behavior, Animal; Female; Glutamic Acid; Hydrogen-Ion Concentration; Mice; Nerve Fibers, Unmyelinated; Nerve Tissue Proteins; Pain; Pain Measurement; Protons; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Solutions; TRPV Cation Channels | 2010 |
Effects of local tramadol administration on peripheral glutamate-induced nociceptive behaviour in mice.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Female; Foot; Glutamic Acid; Hot Temperature; Immersion; Lidocaine; Mice; Pain; Pain Measurement; Tramadol | 2010 |
Analgesic properties of the novel amino acid, isovaline.
Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; beta-Alanine; Chronic Disease; Cisterna Magna; Female; Formaldehyde; Glutamic Acid; Glycine; Hypnotics and Sedatives; Injections; Injections, Intravenous; Injections, Spinal; Mice; Models, Molecular; Pain; Pain Measurement; Postural Balance; Receptors, Glutamate; Strychnine; Valine | 2010 |
MK-801 changes the role of glutamic acid on modulation of algesia in nucleus accumbens.
Topics: Analgesics; Animals; Dizocilpine Maleate; Glutamic Acid; Male; Neurons; Nucleus Accumbens; Pain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2010 |
A diminished response to formalin stimulation reveals a role for the glutamate transporters in the altered pain sensitivity of mice with experimental autoimmune encephalomyelitis (EAE).
Topics: Amino Acid Sequence; Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Formaldehyde; Glutamic Acid; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Pain; Pain Measurement; Pain Threshold; Phosphorylation; Receptors, Metabotropic Glutamate; Spinal Cord; Synaptic Transmission | 2010 |
Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain.
Topics: Animals; Capsaicin; Glutamic Acid; Inflammation; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Posterior Horn Cells; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate | 2010 |
Antinociceptive effect of stimulating the occipital or retrosplenial cortex in rats.
Topics: Analgesics; Animals; Electric Stimulation Therapy; Ethanol; Glutamic Acid; Gyrus Cinguli; Male; Motor Activity; Neural Inhibition; Neural Pathways; Occipital Lobe; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar | 2010 |
Norepinephrine plays an important role in antinociceptive modulation of hypothalamic paraventricular nucleus in the rat.
Topics: Animals; Glutamic Acid; Male; Neurotransmitter Agents; Norepinephrine; Pain; Pain Measurement; Pain Threshold; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter | 2010 |
Assessment of the potential role of muscle spindle mechanoreceptor afferents in chronic muscle pain in the rat masseter muscle.
Topics: Afferent Pathways; Animals; Behavior, Animal; Chronic Disease; Glutamic Acid; Male; Masseter Muscle; Mechanoreceptors; Membrane Potentials; Pain; Rats; Rats, Sprague-Dawley | 2010 |
Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate.
Topics: Adult; Aspartic Acid; Brain; Cholic Acid; Cross-Sectional Studies; Diffusion Tensor Imaging; Female; Fibromyalgia; Glutamic Acid; Glutamine; Hippocampus; Humans; Inositol; Male; Middle Aged; Motor Cortex; Nuclear Magnetic Resonance, Biomolecular; Pain; Protons; Somatosensory Cortex | 2010 |
A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model.
Topics: Analysis of Variance; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Glutamic Acid; Osteoarthritis, Knee; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Tetrahydronaphthalenes; TRPV Cation Channels | 2010 |
Inhibition of inflammatory pain by activating B-type natriuretic peptide signal pathway in nociceptive sensory neurons.
Topics: Analysis of Variance; Animals; Antibodies; Biophysical Phenomena; Calcitonin Gene-Related Peptide; Carbazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Glutamic Acid; Hyperalgesia; Inflammation; Lectins; Male; Membrane Potentials; Natriuretic Peptide, Brain; Pain; Pain Measurement; Patch-Clamp Techniques; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; Sensory Receptor Cells; Signal Transduction; Time Factors | 2010 |
Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Gene Knock-In Techniques; Glutamic Acid; Inflammation; Mice; Mice, Inbred C57BL; Models, Neurological; Neuralgia; Nitric Oxide Synthase Type I; Pain; Phosphorylation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Spinal Nerves | 2010 |
Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice.
Topics: Analgesics; Animals; Capsaicin; Chalcones; Flavonoids; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Models, Chemical; Motor Activity; Pain; Pain Measurement; Plant Extracts; Reaction Time; Receptors, Opioid | 2010 |
Excrescence of neurotransmitter glutamate from disc material has nociceptive qualities: evidence from a rat model.
Topics: Animals; Behavior, Animal; Epidural Space; Female; Ganglia, Spinal; Glutamic Acid; Immunohistochemistry; Intervertebral Disc; Neurotransmitter Agents; Pain; Radiculopathy; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 2010 |
Insula-specific responses induced by dental pain. A proton magnetic resonance spectroscopy study.
Topics: Adult; Aspartic Acid; Cerebral Cortex; Electrodes; Female; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Spectroscopy; Male; Middle Aged; Models, Anatomic; Neurotransmitter Agents; Pain; Prospective Studies; Protons; Tooth Diseases; Trigeminal Nerve | 2011 |
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.
Topics: Acute Disease; Animals; Capsaicin; Cell Count; Chronic Disease; Glutamic Acid; Immunohistochemistry; Mice; Mice, Knockout; Mice, Transgenic; Mutation; NAV1.8 Voltage-Gated Sodium Channel; Neural Pathways; Neurons; Nociceptors; Pain; Patch-Clamp Techniques; Pruritus; Receptors, Bombesin; Sodium Channels; Spinal Cord; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2010 |
Intraplantar injection of gangliosides produces nociceptive behavior and hyperalgesia via a glutamate signaling mechanism.
Topics: Animals; Behavior, Animal; Gangliosides; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Sensory Receptor Cells; Signal Transduction | 2011 |
Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Inflammation; Kainic Acid; Male; Nicotinic Acids; Pain; Phosphoserine; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord | 2011 |
Oxytocin, but not arginine vasopressin is involving in the antinociceptive role of hypothalamic supraoptic nucleus.
Topics: Analgesics; Animals; Arginine Vasopressin; Glutamic Acid; Hypothalamus; Injections, Intraventricular; Male; Oxytocin; Pain; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Supraoptic Nucleus | 2011 |
The analgesic effects and mechanisms of orally administered eugenol.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Brain; Disease Models, Animal; Eugenol; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Receptors, Serotonin; Substance P | 2011 |
Antinociceptive effect of the essential oil of Zingiber zerumbet in mice: possible mechanisms.
Topics: Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Injections, Intraperitoneal; KATP Channels; Male; Medicine, Traditional; Mice; Mice, Inbred ICR; Neural Pathways; Nitric Oxide; Oils, Volatile; Pain; Pain Measurement; Pain Threshold; Plant Oils; Plant Roots; Plants, Medicinal; Protein Kinase C; Signal Transduction; TRPV Cation Channels; Zingiber officinale | 2011 |
Effects of inducible nitric oxide synthase blockade within the periaqueductal gray on cardiovascular responses during mechanical, heat, and cold nociception.
Topics: Animals; Blood Pressure; Cold Temperature; Enzyme Inhibitors; Female; gamma-Aminobutyric Acid; Glutamic Acid; Guanidines; Heart Rate; Hot Temperature; Microdialysis; Nitric Oxide Synthase Type II; Nociception; Pain; Periaqueductal Gray; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2012 |
Response properties of nociceptive neurons in the caudal ventrolateral medulla (CVLM) in monoarthritic and healthy control rats: modulation of responses by the paraventricular nucleus of the hypothalamus (PVN).
Topics: Animals; Arthritis, Experimental; Electrophysiology; Glutamic Acid; Male; Medulla Oblongata; Microinjections; Nociceptors; Pain; Pain Measurement; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar | 2011 |
Contribution of peripheral vanilloid receptor to the nociception induced by injection of spermine in mice.
Topics: Acid Sensing Ion Channels; Animals; Biogenic Polyamines; Blotting, Western; Diterpenes; Glutamic Acid; Male; Mice; Nerve Fibers; Nerve Tissue Proteins; Nociceptors; Pain; Pain Measurement; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Spermine; TRPV Cation Channels | 2011 |
Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors.
Topics: Amino Acids; Animals; Calcium; Capsaicin; Cells, Cultured; Cytosol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Skin; TRPV Cation Channels; Xanthenes | 2011 |
Short-term cortical plasticity induced by conditioning pain modulation.
Topics: Adult; Analysis of Variance; Brain Mapping; Cerebral Cortex; Electric Stimulation; Electroencephalography; Evoked Potentials, Somatosensory; Female; Glutamic Acid; Humans; Injections, Intramuscular; Magnetic Resonance Imaging; Male; Neuronal Plasticity; Pain; Pain Measurement; Pain Threshold; Psychophysics; Reaction Time; Young Adult | 2012 |
Antinociceptive effect of stimulating the zona incerta with glutamate in rats.
Topics: Analgesics; Animals; Atropine; Glutamic Acid; Haloperidol; Male; Mecamylamine; Methysergide; Microinjections; Naloxone; Pain; Pain Measurement; Phenoxybenzamine; Rats; Rats, Wistar; Subthalamic Nucleus; Subthalamus | 2012 |
Modulatory role of glutamic acid on the electrical activities of pain-related neurons in the hippocampal CA3 region.
Topics: Animals; CA3 Region, Hippocampal; Dizocilpine Maleate; Electric Stimulation; Electrophysiological Phenomena; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Microelectrodes; Neurons; Pain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques | 2012 |
Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.
Topics: Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Solvents; Time Factors; Water | 2012 |
The involvement of the spinal release of glutamate and nitric oxide in peripheral noxious stimulation-induced pain-related behaviors--study in mouse spinal microdialysis.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glutamic Acid; Male; Mice; Microdialysis; Nitric Oxide; Pain; Pain Measurement; Spinal Cord | 2012 |
Rapid changes in extracellular glutamate induced by natural arousing stimuli and intravenous cocaine in the nucleus accumbens shell and core.
Topics: Analysis of Variance; Animals; Body Temperature; Brain; Cocaine; Dopamine Uptake Inhibitors; Electrochemistry; Extracellular Fluid; Glutamic Acid; Infusions, Intravenous; Interpersonal Relations; Locomotion; Male; Nucleus Accumbens; Pain; Physical Stimulation; Rats; Rats, Long-Evans; Self Administration; Wakefulness | 2012 |
[Peripheral acting mediators pain and analgesia potentiate the central analgesic action of fentanyl and dipyrone].
Topics: Adenosine; Adenosine Triphosphate; Analgesia; Analgesics; Animals; Dipyrone; Dose-Response Relationship, Drug; Drug Synergism; Fentanyl; Glutamic Acid; Male; Pain; Phenylephrine; Rats; Rats, Wistar | 2012 |
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat.
Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal | 2012 |
N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain.
Topics: Animals; Biological Transport; Calpain; Chlorides; Electrophysiology; Glutamic Acid; Homeostasis; K Cl- Cotransporters; Male; Neuralgia; Neuronal Plasticity; Pain; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Symporters; Synapses | 2012 |
Evaluation of formalin-induced pain behavior and glutamate release in the spinal dorsal horn using in vivo microdialysis in conscious rats.
Topics: Animals; Formaldehyde; Glutamic Acid; Male; Microdialysis; Pain; Rats; Rats, Wistar; Spinal Cord | 2012 |
Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glycine; Male; Microdialysis; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Time Factors | 2002 |
Dynamic determination and possible mechanism of amino acid transmitter release from rat spinal dorsal horn induced by the venom and a neurotoxin (BmK I) of scorpion Buthus martensi Karsch.
Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Neurotransmitter Agents; Nociceptors; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Scorpion Venoms | 2002 |
Spinal cord heme oxygenase participates in glutamate-induced pain-related behaviors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Heme Oxygenase (Decyclizing); In Vitro Techniques; Injections, Spinal; Male; Mesoporphyrins; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Protoporphyrins; Spinal Cord | 2002 |
Inhibition of tonic spinal glutamatergic activity induces antinociception in the rat.
Topics: Afferent Pathways; Animals; Calcium Channel Blockers; Calcium Channels; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Neural Inhibition; Neural Pathways; Neurokinin-1 Receptor Antagonists; Nociceptors; Nucleus Accumbens; Opioid Peptides; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Synaptic Transmission | 2002 |
Influence of sex on reflex jaw muscle activity evoked from the rat temporomandibular joint.
Topics: Animals; Disease Models, Animal; Estrogens; Estrous Cycle; Female; Glutamic Acid; Gonadal Steroid Hormones; Male; Masticatory Muscles; Muscle Contraction; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Reflex; Sex Characteristics; Temporomandibular Joint; Temporomandibular Joint Disorders | 2002 |
Glutamate-evoked pain and mechanical allodynia in the human masseter muscle.
Topics: Adult; Analysis of Variance; Excitatory Amino Acids; Female; Glutamic Acid; Humans; Male; Masseter Muscle; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Reaction Time; Sex Characteristics; Time Factors | 2003 |
The role of neuropeptides and capsaicin-sensitive fibres in glutamate-induced nociception and paw oedema in mice.
Topics: Animals; Benzamides; Bradykinin Receptor Antagonists; Calcitonin Gene-Related Peptide; Capsaicin; Dipeptides; Edema; Foot; Glutamic Acid; Indoles; Male; Mice; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Piperidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 2003 |
Antinociceptive mechanisms of orally administered decursinol in the mouse.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzopyrans; Butyrates; Cyproheptadine; Dose-Response Relationship, Drug; Glutamic Acid; Histamine H2 Antagonists; Interferon-gamma; Interleukin-1; Male; Methysergide; Mice; Mice, Inbred ICR; Models, Chemical; Naloxone; Narcotic Antagonists; Pain; Piperidines; Protein Kinase C; Ranitidine; Receptors, Adrenergic; Receptors, Histamine; Receptors, Purinergic P1; Receptors, Serotonin; Serotonin Antagonists; Substance P; Theobromine; Tumor Necrosis Factor-alpha; Xanthines; Yohimbine | 2003 |
Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle.
Topics: Adult; Afferent Pathways; Analysis of Variance; Animals; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glutamic Acid; Humans; Male; Masseter Muscle; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric | 2003 |
Psychiatric drugs. Excited by glutamate.
Topics: Animals; Anxiety Disorders; Brain; Brain Diseases; Bridged Bicyclo Compounds; Clinical Trials as Topic; Depressive Disorder; Dopamine; Excitatory Amino Acid Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Mental Disorders; Neurons; Pain; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Substance-Related Disorders; Synaptic Transmission | 2003 |
[Selected cases from practical neurology; painful muscle spasm, anxiety conditions, and glutamic acid].
Topics: Anxiety; Anxiety Disorders; Glutamates; Glutamic Acid; Humans; Muscle Cramp; Nervous System Diseases; Neurology; Neurotic Disorders; Pain; Spasm | 1955 |
The roles of different types of glutamate receptors involved in the mediation of nucleus submedius (Sm) glutamate-evoked antinociception in the rat.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microinjections; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Thalamus | 2003 |
Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Synergism; Enzyme Inhibitors; Extracellular Fluid; Formaldehyde; Glutamic Acid; Injections, Spinal; Male; Microdialysis; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord | 2003 |
Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Glutamic Acid; Ibuprofen; Injections, Spinal; Ligation; Male; Microdialysis; Pain; Pain Measurement; Physical Stimulation; Prostaglandin Antagonists; Prostaglandins; Pyrazoles; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2003 |
Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Injections, Spinal; Male; Microdialysis; Morphine; Pain; Pain Measurement; Rats; Rats, Wistar; Time Factors | 2004 |
GABAergic projection from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal raphe nucleus.
Topics: Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cholera Toxin; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Isoenzymes; Male; Neural Pathways; Neurons; Pain; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Stress, Physiological; Substantia Nigra; Ventral Tegmental Area | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Edema; Formaldehyde; Glutamic Acid; Inhibition, Psychological; Injections, Subcutaneous; Male; Morphine; Motor Activity; Narcotics; Neuromuscular Agents; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Time Factors | 2004 |
Reduction by gabapentin of K+-evoked release of [3H]-glutamate from the caudal trigeminal nucleus of the streptozotocin-treated rat.
Topics: Acetates; Amines; Animals; Blood Glucose; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Pain; Pain Measurement; Physical Stimulation; Potassium; Rats; Trigeminal Nuclei | 2004 |
Glutamatergic activation of anterior cingulate cortex produces an aversive teaching signal.
Topics: Animals; Avoidance Learning; Conditioning, Psychological; Glutamic Acid; Gyrus Cinguli; Male; Neural Pathways; Pain; Rats; Rats, Long-Evans | 2004 |
The role of the N-methyl-D-aspartate receptor NR1 subunit in peripheral nerve injury-induced mechanical allodynia, glial activation and chemokine expression in the mouse.
Topics: Animals; Axotomy; Blotting, Western; Chemokines; Glutamic Acid; Immunohistochemistry; Lumbosacral Region; Mice; Mice, Knockout; Neuroglia; Pain; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerves | 2004 |
Differential release of neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflammation of the rat paw.
Topics: Afferent Pathways; Animals; Arginine; Aspartic Acid; Chondrus; Extracellular Fluid; Foot; gamma-Aminobutyric Acid; Glutamic Acid; Inflammation; Male; Microdialysis; Neurotransmitter Agents; Pain; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Wistar; Reaction Time; Synaptic Transmission; Up-Regulation | 2004 |
Glutamate-evoked release of adenosine and regulation of peripheral nociception.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Citrates; Conditioning, Psychological; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Formaldehyde; Gliosis; Glutamic Acid; Male; Microglia; Neural Inhibition; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Spinal Cord; Theophylline | 2004 |
NMDA receptors in the anterior cingulate cortex mediate pain-related aversion.
Topics: Animals; Avoidance Learning; Emotions; Excitatory Amino Acid Antagonists; Glutamic Acid; Gyrus Cinguli; Immunohistochemistry; Male; Nociceptors; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2004 |
Vanilloid receptor VR1-positive primary afferents are glutamatergic and contact spinal neurons that co-express neurokinin receptor NK1 and glutamate receptors.
Topics: Afferent Pathways; Animals; Capsaicin; Fluorescent Antibody Technique; Glutamic Acid; Immunohistochemistry; Male; Membrane Transport Proteins; Microscopy, Electron, Transmission; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Nerve Roots; Substance P; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2004 |
Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise.
Topics: Creatine; Female; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Lactic Acid; Microdialysis; Muscle, Skeletal; Occupational Diseases; Pain; Pain Measurement; Physical Exertion; Pyruvic Acid; Regional Blood Flow; Rest; Serotonin; Spectrophotometry; Time Factors; Ultrasonography | 2004 |
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.
Topics: Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Extracellular Space; Free Radicals; Glutamic Acid; Male; Microdialysis; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Pain; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Reserpine | 2005 |
Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways.
Topics: Acetic Acid; Analgesics; Animals; Bradykinin; Cyclic AMP-Dependent Protein Kinases; Diterpenes; Dose-Response Relationship, Drug; Drug Combinations; Formaldehyde; Glutamic Acid; Heart; Male; Mice; Oleanolic Acid; Pain; Pain Measurement; Peripheral Nervous System; Physical Stimulation; Protein Kinase C; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord; Stimulation, Chemical; Triterpenes | 2005 |
Dietary glutamate and fibromyalgia.
Topics: Animals; Diet; Female; Fibromyalgia; Glutamic Acid; Humans; Male; Nociceptors; Pain; Sex Factors | 2005 |
[Influence of glutamate and NMDA-receptor antagonist MK-801 on the electric activities of pain-excitation neurons in the nucleus accumbens of rats].
Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiological Phenomena; Female; Glutamic Acid; Male; Neurons; Nociceptors; Nucleus Accumbens; Pain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2005 |
Physiological and behavioral evidence for focal nociception induced by epidural glutamate infusion in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Glutamic Acid; Hyperalgesia; Infusion Pumps, Implantable; Injections, Epidural; Lumbar Vertebrae; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Single-Blind Method; Spinal Cord | 2005 |
Nociceptive transmitter release in the dorsal spinal cord by capsaicin-sensitive fibers after noxious gastric stimulation.
Topics: Amino Acid Transport System X-AG; Animals; Autonomic Denervation; Calcitonin Gene-Related Peptide; Capsaicin; Female; Ganglia, Spinal; Gastric Mucosa; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Immunohistochemistry; Ion Channels; Neurons, Afferent; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Symporters; Thoracic Vertebrae; TRPV Cation Channels; Visceral Afferents | 2005 |
Glutamate uptake is attenuated in spinal deep dorsal and ventral horn in the rat spinal nerve ligation model.
Topics: Amino Acid Transport System X-AG; Animals; Anterior Horn Cells; Biosensing Techniques; Disease Models, Animal; Electrochemistry; Glutamic Acid; Ligation; Lumbar Vertebrae; Male; Microdialysis; Microelectrodes; Neuronal Plasticity; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves | 2005 |
Glutamate transporter: an unexpected target for some antibiotics.
Topics: Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Drug Delivery Systems; Glutamic Acid; Pain; Rats | 2005 |
Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamic Acid; Male; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission | 2005 |
No release of interstitial glutamate in experimental human model of muscle pain.
Topics: Acute Disease; Adult; Electromyography; Extracellular Fluid; Female; Glutamic Acid; Humans; Male; Microdialysis; Middle Aged; Models, Neurological; Muscle, Skeletal; Pain; Regional Blood Flow | 2005 |
Protein phosphatase modulates the phosphorylation of spinal cord NMDA receptors in rats following intradermal injection of capsaicin.
Topics: Administration, Cutaneous; Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Glutamic Acid; Male; Microdialysis; Neurons, Afferent; Nociceptors; Pain; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 2005 |
Combined therapy with clonidine and amantadine may act in two stages of glutamate-mediated neuropathic pain caused by a needle puncture in an upper extremity.
Topics: Adrenergic alpha-Agonists; Adult; Amantadine; Analgesics, Non-Narcotic; Calcium Channel Blockers; Catheterization, Peripheral; Clonidine; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Ketamine; Median Nerve; Pain; Peripheral Nervous System Diseases; Receptors, N-Methyl-D-Aspartate | 2005 |
Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bradykinin; Drug Synergism; Glutamic Acid; Hyperalgesia; In Vitro Techniques; Mice; Mice, Knockout; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Spinal Cord; Synaptic Transmission | 2005 |
Local application of morphine suppresses glutamate-evoked activities of C and Adelta afferent fibers in rat hairy skin.
Topics: Action Potentials; Afferent Pathways; Analgesics, Opioid; Animals; Glutamic Acid; Hair; Hair Follicle; Mechanoreceptors; Morphine; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Skin | 2005 |
Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Glutamic Acid; Inflammation Mediators; Male; Myenteric Plexus; Neuronal Plasticity; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Trinitrobenzenesulfonic Acid; Up-Regulation; Visceral Afferents | 2006 |
Increased expression of cyclooxygenase and nitric oxide isoforms, and exaggerated sensitivity to prostaglandin E2, in the rat lumbar spinal cord 3 days after L5-L6 spinal nerve ligation.
Topics: Animals; Blotting, Western; Dinoprostone; Dose-Response Relationship, Drug; Glutamic Acid; Injections, Spinal; Isoenzymes; Ligation; Male; Nitric Oxide Synthase; Pain; Peripheral Nervous System Diseases; Physical Stimulation; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves | 2006 |
Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Capsaicin; Combretum; Endorphins; Flowers; Formaldehyde; Glutamic Acid; Male; Mice; Motor Activity; Nitric Oxide; Pain; Pain Measurement; Plant Extracts; Psychomotor Performance; Reaction Time; Serotonin; Triterpenes | 2006 |
Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interaction between the peripheral opioid and glutamate systems.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Capsaicin; Disease Models, Animal; Drug Interactions; Electric Stimulation; Glutamic Acid; Hot Temperature; Male; Morphine; Narcotic Antagonists; Nerve Fibers, Unmyelinated; Neural Conduction; Nociceptors; Opioid Peptides; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Opioid; Sensory Receptor Cells; Signal Transduction | 2006 |
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hyperalgesia; Indomethacin; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Pain; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley | 2006 |
Activation of alpha2-adrenoreceptors suppresses the excitability of C1 spinal neurons having convergent inputs from tooth pulp and superior sagittal sinus in rats.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Afferent Pathways; Analgesics; Animals; Cervical Vertebrae; Cranial Sinuses; Dental Pulp; Drug Interactions; Electric Stimulation; Glutamic Acid; Immunohistochemistry; Male; Neural Inhibition; Neurons, Afferent; Nociceptors; Pain; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Spinal Cord | 2006 |
Effects of muscle fatigue induced by low-level clenching on experimental muscle pain and resting jaw muscle activity: gender differences.
Topics: Adult; Analysis of Variance; Bite Force; Electromyography; Female; Glutamic Acid; Humans; Male; Masticatory Muscles; Muscle Fatigue; Muscular Diseases; Pain; Pain Measurement; Sex Characteristics; Time Factors | 2006 |
Medullary monoamines and NMDA-receptor regulation of cardiovascular responses during peripheral nociceptive stimuli.
Topics: Afferent Pathways; Animals; Biogenic Monoamines; Blood Pressure; Cardiovascular Physiological Phenomena; Dopamine; Epinephrine; Excitatory Amino Acid Antagonists; Extracellular Fluid; Female; Glutamic Acid; Heart Rate; Medulla Oblongata; Microdialysis; Nociceptors; Norepinephrine; Pain; Physical Stimulation; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reticular Formation; Serotonin | 2006 |
The glutamate transporter GLAST is involved in spinal nociceptive processing.
Topics: Amino Acid Transport System X-AG; Animals; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Neurons; Oligonucleotides, Antisense; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission; Zymosan | 2006 |
Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Nociceptors; Pain; Receptors, Glutamate; Spinal Cord | 2006 |
Neurochemistry of trigeminal activation in an animal model of migraine.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Microdialysis; Migraine Disorders; Pain; Rats; Trigeminal Nerve | 2006 |
Galanin receptor 1 is expressed in a subpopulation of glutamatergic interneurons in the dorsal horn of the rat spinal cord.
Topics: Animals; Excitatory Postsynaptic Potentials; Galanin; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; In Situ Hybridization; Interneurons; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Nociceptors; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptor, Galanin, Type 1; RNA, Messenger; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2006 |
Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry, Physical; CHO Cells; Chronic Disease; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutamic Acid; Pain; Pyrazines; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 2007 |
TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons.
Topics: Action Potentials; Afferent Pathways; Animals; Autonomic Pathways; Capsaicin; Cardiovascular Physiological Phenomena; Diterpenes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Inhibitory Postsynaptic Potentials; Male; Neurons; Organ Culture Techniques; Pain; Patch-Clamp Techniques; Periaqueductal Gray; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synaptic Transmission; TRPV Cation Channels | 2007 |
Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate.
Topics: Afferent Pathways; Animals; Capsaicin; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Inhibitory Postsynaptic Potentials; Interneurons; Male; Neural Inhibition; Nociceptors; Organ Culture Techniques; Pain; Pertussis Toxin; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Spinal Nerve Roots; Synaptic Transmission | 2007 |
Changes in pain behavior induced by formalin, substance P, glutamate and pro-inflammatory cytokines in immobilization-induced stress mouse model.
Topics: Analgesia; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Glutamic Acid; Inflammation Mediators; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Pain Measurement; Pain Threshold; Restraint, Physical; Stress, Psychological; Substance P | 2006 |
Arginine vasopressin in periaqueductal gray, which relates to antinociception, comes from hypothalamic paraventricular nucleus in the rat.
Topics: Animals; Arginine Vasopressin; Denervation; Dose-Response Relationship, Drug; Electrocoagulation; Extracellular Fluid; Glutamic Acid; Male; Neural Pathways; Neurons; Nociceptors; Pain; Paraventricular Hypothalamic Nucleus; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Up-Regulation | 2007 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Lamotrigine; Male; Microdialysis; Pain; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Long-Evans; Riluzole; Spinal Cord; Touch; Triazines | 2007 |
The colocalization of CGRP receptor and AMPA receptor in the spinal dorsal horn neuron of rat: a morphological and electrophysiological study.
Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcitonin Gene-Related Peptide; Evoked Potentials; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glutamic Acid; Male; Nociceptors; Pain; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Calcitonin Gene-Related Peptide; Sensation; Spinal Nerve Roots; Synaptic Transmission | 2007 |
Analysis of the mechanism of antinociceptive action of niga-ichigoside F1 obtained from Rubus imperialis (Rosaceae).
Topics: Analgesics; Animals; Apomorphine; Atropine; Capsaicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glutamic Acid; Haloperidol; Injections, Intraperitoneal; Male; Mice; Molecular Structure; Morphine; Naloxone; Nitroarginine; Pain; Pain Measurement; Plant Extracts; Rosaceae; Saponins; Yohimbine | 2006 |
Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat.
Topics: Acetylcholine; Animals; Arginine Vasopressin; beta-Endorphin; Choline; Dopamine; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Epinephrine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Norepinephrine; Opioid Peptides; Oxytocin; Pain; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Serotonin | 2007 |
Bidirectional synaptic plasticity at nociceptive afferents in the rat central amygdala.
Topics: Adenylyl Cyclases; Amygdala; Animals; Calcium Signaling; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Isoquinolines; Long-Term Potentiation; Long-Term Synaptic Depression; Neuronal Plasticity; Neurons, Afferent; Nociceptors; Okadaic Acid; Pain; Phosphoprotein Phosphatases; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Synaptic Transmission | 2007 |
Involvement of cellular prion protein in the nociceptive response in mice.
Topics: Acetic Acid; Analysis of Variance; Animals; Behavior, Animal; Edema; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Knockout; Pain; Pain Measurement; Pain Threshold; PrPC Proteins; Reaction Time; Temperature | 2007 |
Inward currents induced by ischemia in rat spinal cord dorsal horn neurons.
Topics: Age Factors; Animals; Animals, Newborn; Capsaicin; Electric Stimulation; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Ischemia; Organ Culture Techniques; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord | 2007 |
Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels.
Topics: Acetic Acid; Analgesics; Animals; Calcium Channels; Calcium Radioisotopes; Calcium Signaling; Capsaicin; Female; Flavonoids; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gi-Go; Injections, Intraventricular; Injections, Spinal; Interleukin-1beta; Ion Channel Gating; Male; Mice; Pain; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Substance P; Tumor Necrosis Factor-alpha | 2007 |
Role of spinal metabotropic glutamate receptor subtype 5 in the development of tolerance to morphine-induced antinociception in rat.
Topics: Analgesics, Opioid; Animals; Calcium; Drug Administration Schedule; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Injections, Spinal; Male; Morphine; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Phenylacetates; Protein Kinase C; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Spinal Cord; Synaptic Transmission; Up-Regulation | 2007 |
Riluzole, a glutamate release inhibitor, induces loss of righting reflex, antinociception, and immobility in response to noxious stimulation in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Glutamic Acid; Immobilization; Male; Mice; Movement; Pain; Pain Measurement; Physical Stimulation; Reflex; Riluzole | 2007 |
Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment.
Topics: Animals; Behavior, Animal; Early Growth Response Protein 1; Environment; Excitatory Postsynaptic Potentials; Formaldehyde; Glutamic Acid; Gyrus Cinguli; Hindlimb; In Vitro Techniques; Inflammation; Injections, Subcutaneous; Long-Term Potentiation; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Pain; Presynaptic Terminals; Receptors, N-Methyl-D-Aspartate; Safety; Synaptic Transmission; Time Factors | 2007 |
The intracerebroventricular kainic acid-induced damage affects animal nociceptive behavior.
Topics: Animals; Behavior, Animal; Cytokines; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; Neurons; Pain; Pain Measurement; Substance P | 2007 |
[Extracellular aminoacids in the amygdala and nucleus accumbens in the rat during acute pain].
Topics: Acute Disease; Amygdala; Animals; Arginine; Aspartic Acid; Glutamic Acid; Male; Nucleus Accumbens; Pain; Rats; Rats, Wistar | 2007 |
Intrathecal substance P (1-7) prevents morphine-evoked spontaneous pain behavior via spinal NMDA-NO cascade.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Glutamic Acid; Male; Morphine; N-Methylaspartate; Nitrates; Nitric Oxide; Nitrites; Pain; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 2007 |
Inhibition of glutamatergic transmission by morphine in the basolateral amygdaloid nucleus reduces pain-induced aversion.
Topics: Amygdala; Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extracellular Fluid; Fear; Glutamic Acid; Male; Microdialysis; Morphine; Neural Inhibition; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Up-Regulation | 2007 |
Decreased pain response in mice following cortex-specific knockout of the N-methyl-D-aspartate NR1 subunit.
Topics: Afferent Pathways; Animals; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Female; Glutamic Acid; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Pain; Pain Measurement; Pain Threshold; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Synaptic Transmission | 2007 |
A synthetic kainoid, (2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid (PSPA-1) serves as a novel anti-allodynic agent for neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hyperalgesia; Immunohistochemistry; Inflammation; Kainic Acid; Mice; Mononeuropathies; N-Methylaspartate; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Spinal Cord; Time Factors | 2007 |
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
Topics: Analgesics, Opioid; Animals; Calcium Signaling; Central Nervous System; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hyperalgesia; Male; Mice; Morphine; Nociceptors; Pain; Placebo Effect; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission | 2008 |
Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetic Acid; Analgesics; Animals; Benzene Derivatives; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Edema; Enzyme Activators; Excitatory Amino Acids; Female; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; Immersion; Injections, Spinal; Mice; Motor Activity; Organoselenium Compounds; Pain; Reaction Time; Signal Transduction | 2008 |
Role of nitric oxide/cyclic GMP/K(+) channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol.
Topics: Analgesics; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Formaldehyde; Glutamic Acid; Glyburide; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organoselenium Compounds; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Potassium Channels; Rats; Rats, Wistar; Serotonin; Signal Transduction | 2007 |
Keeping in check painful synapses in central amygdala.
Topics: Adrenergic alpha-Agonists; Amygdala; Animals; Emotions; Glutamic Acid; Humans; Nerve Fibers; Neural Pathways; Neurotransmitter Agents; Norepinephrine; Pain; Synapses; Synaptic Transmission | 2007 |
Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways.
Topics: Action Potentials; Animals; Brain Stem; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; Male; Microdialysis; Microinjections; Neural Pathways; Neurons, Efferent; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Sensory System Agents; TRPV Cation Channels | 2007 |
The differential effects of emotional or physical stress on pain behaviors or on c-Fos immunoreactivity in paraventricular nucleus or arcuate nucleus.
Topics: Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Chronic Disease; Disease Models, Animal; Glutamic Acid; Immunohistochemistry; Injections, Spinal; Interferon-gamma; Interleukin-1beta; Male; Mice; Mice, Inbred ICR; Pain; Pain Threshold; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Statistics, Nonparametric; Stress, Psychological; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Post-synaptic action of morphine on glutamatergic neuronal transmission related to the descending antinociceptive pathway in the rat thalamus.
Topics: Animals; Dose-Response Relationship, Radiation; Electric Stimulation; Embryo, Mammalian; Glutamic Acid; Injections, Spinal; Male; Microinjections; Morphine; Narcotics; Neuroglia; Neurons; Pain; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stilbamidines; Synaptic Transmission; Thalamus | 2008 |
Anterior cingulate cortex modulates visceral pain as measured by visceromotor responses in viscerally hypersensitive rats.
Topics: Albumins; Anaphylaxis; Animals; Colon; Disease Models, Animal; Electric Stimulation; Glutamic Acid; Gyrus Cinguli; Hypersensitivity; Male; Motor Cortex; Neurons; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Viscera | 2008 |
Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signalling in spinal cord in mice.
Topics: Animals; Cyclic GMP; Glutamic Acid; Male; Mice; Nitric Oxide; Pain; Pain Measurement; Platelet Activating Factor; Receptors, Glycine; Signal Transduction; Spinal Cord; Touch | 2008 |
Down-regulation of NR2B receptors partially contributes to analgesic effects of Gentiopicroside in persistent inflammatory pain.
Topics: Analgesics, Non-Narcotic; Animals; Blotting, Western; Chronic Disease; Cyclic AMP; Down-Regulation; Excitatory Postsynaptic Potentials; Freund's Adjuvant; Glucosides; Glutamic Acid; Inflammation; Iridoid Glucosides; Iridoids; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Patch-Clamp Techniques; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2008 |
The influence of sex and ovarian hormones on temporomandibular joint nociception in rats.
Topics: Animals; Behavior, Animal; Diestrus; Estradiol; Female; Formaldehyde; Glutamic Acid; Humans; Injections, Intra-Articular; Injections, Intraperitoneal; Male; Nociceptors; Ovariectomy; Pain; Pain Measurement; Proestrus; Progesterone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sex Factors; Temporomandibular Joint; Temporomandibular Joint Disorders | 2008 |
Mechanisms of prolonged presynaptic Ca2+ signaling and glutamate release induced by TRPV1 activation in rat sensory neurons.
Topics: Action Potentials; Afferent Pathways; Animals; Animals, Newborn; Arachidonic Acids; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Coculture Techniques; Dopamine; Ganglia, Spinal; Glutamic Acid; Mitochondria; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Synaptic Transmission; TRPV Cation Channels | 2008 |
Analgesia produced by microinjection of L-glutamate into the rostral ventromedial bulbar nuclei of the rat and its inhibition by intrathecal alpha-adrenergic blocking agents.
Topics: Adrenergic alpha-Antagonists; Animals; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Male; Medulla Oblongata; Norepinephrine; Pain; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Inbred Strains; Reticular Formation; Serotonin | 1983 |
Evidence that diffuse noxious inhibitory controls (DNIC) are medicated by a final post-synaptic inhibitory mechanism.
Topics: Animals; Bradykinin; Glutamates; Glutamic Acid; Hot Temperature; Male; Neural Inhibition; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Synaptic Transmission | 1984 |
Diffuse noxious inhibitory controls (DNIC): evidence for post-synaptic inhibition of trigeminal nucleus caudalis convergent neurones.
Topics: Animals; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Male; Neural Inhibition; Pain; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission; Trigeminal Caudal Nucleus; Trigeminal Nucleus, Spinal | 1984 |
Spinal monoamine and opiate systems partly mediate the antinociceptive effects produced by glutamate at brainstem sites.
Topics: Analgesics; Animals; Biogenic Amines; Endorphins; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Male; Medulla Oblongata; Pain; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Inbred Strains; Spinal Cord | 1984 |
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P | 1994 |
Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats.
Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Dinoprostone; Formaldehyde; Glutamic Acid; Hindlimb; Ibuprofen; Injections, Spinal; Male; Microdialysis; Pain; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors | 1995 |
Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice.
Topics: Animals; Bicuculline; Dinoprostone; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Pain; Prostaglandin D2; Strychnine | 1994 |
Involvement of glutamate receptors in allodynia induced by prostaglandins E2 and F2 alpha injected into conscious mice.
Topics: Animals; Dinoprost; Dinoprostone; Glutamates; Glutamic Acid; Injections, Spinal; Mice; Neurotransmitter Agents; Pain; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1994 |
Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception.
Topics: Animals; Binding Sites; Ganglia, Spinal; Gene Expression Regulation; Glutamates; Glutamic Acid; Male; Nerve Tissue Proteins; Neurotransmitter Agents; Organ Specificity; Pain; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord | 1993 |
Involvement of the frontal ventrolateral orbital cortex in descending inhibition of nociception mediated by the periaqueductal gray in rats.
Topics: Animals; Coloring Agents; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Microinjections; Neural Inhibition; Neural Pathways; Nociceptors; Pain; Periaqueductal Gray; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reflex | 1997 |
Reflex-related activation of putative pain facilitating neurons in rostral ventromedial medulla requires excitatory amino acid transmission.
Topics: Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kynurenic Acid; Male; Medulla Oblongata; Neurons; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reflex; Synaptic Transmission; Tail | 1997 |
Glutamate-positive neurons and terminals in the cat periaqueductal gray matter (PAG): a light and electron microscopic immunocytochemical study.
Topics: Animals; Axons; Cats; Glutamic Acid; Immunohistochemistry; Microscopy, Electron; Neurons; Pain; Periaqueductal Gray; Synapses; Vocalization, Animal | 1997 |
Biphasic modulation of spinal nociceptive transmission from the medullary raphe nuclei in the rat.
Topics: Animals; Electric Stimulation; Glutamic Acid; Male; Neural Pathways; Pain; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord; Stimulation, Chemical; Synaptic Transmission | 1997 |
Peripheral noxious stimulation induces CREM expression in dorsal horn: involvement of glutamate.
Topics: Animals; Cells, Cultured; Cyclic AMP Response Element Modulator; DNA-Binding Proteins; Gene Expression; Genes, fos; Genes, Immediate-Early; Genes, jun; Glutamic Acid; Male; Nociceptors; Pain; Polymerase Chain Reaction; Rats; Rats, Wistar; Repressor Proteins; RNA, Messenger; Signal Transduction; Spinal Cord | 1997 |
Primary afferent tachykinins are required to experience moderate to intense pain.
Topics: Animals; Cloning, Molecular; Female; Gene Targeting; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Neuritis; Neurokinin A; Nociceptors; Pain; Protein Precursors; Receptors, Neurokinin-1; Sensory Thresholds; Sequence Deletion; Stimulation, Chemical; Substance P; Tachykinins | 1998 |
Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice.
Topics: Animals; Antigens, Surface; Axonal Transport; Calcium-Binding Proteins; Cell Death; Cells, Cultured; Central Nervous System; Coculture Techniques; Glutamic Acid; Hippocampus; Kinesins; Membrane Glycoproteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Nervous System Malformations; Neurons; Neurons, Afferent; Pain; Sciatic Nerve; Synaptic Vesicles; Synaptophysin; Synaptotagmins; Syntaxin 1 | 1998 |
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Dipyrone; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Postural Balance; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord | 1998 |
Evidence for the interaction of glutamate and NK1 receptors in the periphery.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Microscopy, Immunoelectron; Neurons, Afferent; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Skin; Substance P; Tail | 1998 |
Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Infusions, Parenteral; Male; Pain; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Remifentanil; Spinal Cord | 1998 |
Silent glutamatergic synapses and nociception in mammalian spinal cord.
Topics: Animals; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Neurons, Afferent; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Serotonin; Spinal Cord; Synapses | 1998 |
Characteristics of neurons with high-frequency discharge in the central nervous system and their relationship to chronic pain. Experimental and clinical investigations.
Topics: Animals; Calcium Channel Blockers; Chronic Disease; Denervation; Disease Models, Animal; Electric Stimulation; Functional Laterality; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Iontophoresis; Microelectrodes; Neural Conduction; Neurons; Nicardipine; Pain; Rats; Rats, Wistar; Spinal Cord; Stereotaxic Techniques; Thalamic Nuclei | 1997 |
Substance P induces brief, localized increase in [Ca2+]i in dorsal horn neurons.
Topics: Animals; Calcium; Cells, Cultured; Dendrites; Fluorescent Dyes; Fura-2; Glutamic Acid; Microscopy, Fluorescence; Neurons; Pain; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1998 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Muscle Contraction; Pain; Pain Measurement; Postural Balance | 1999 |
Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide/cyclic guanosine 3,5-monophosphate/glutamate release cascade in nociceptive signaling.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanylate Cyclase; Male; Microdialysis; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Synaptic Transmission | 1999 |
Chemical activation of cervical cell bodies: effects on responses to colorectal distension in lumbosacral spinal cord of rats.
Topics: Action Potentials; Animals; Colon; Female; Glutamic Acid; Male; Microelectrodes; Neurons; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Rectum; Sacrococcygeal Region; Spinal Cord | 1999 |
Glutamate and kynurenate in the rat central nervous system following treatments with tail ischaemia or diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System; Chromatography, High Pressure Liquid; Diclofenac; Excitatory Amino Acid Antagonists; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Injections, Subcutaneous; Ischemia; Kynurenic Acid; Male; Pain; Rats; Rats, Sprague-Dawley; Tail; Tissue Distribution | 2000 |
Amino acid release into the knee joint: key role in nociception and inflammation.
Topics: Amino Acids; Anesthetics, Local; Animals; Arginine; Arthritis; Carrageenan; Chromatography, High Pressure Liquid; Citrulline; Glutamic Acid; Hindlimb; Injections, Intra-Articular; Joints; Kaolin; Lidocaine; Male; Pain; Rats; Rats, Sprague-Dawley; Synovial Fluid | 2000 |
Role of EGR1 in hippocampal synaptic enhancement induced by tetanic stimulation and amputation.
Topics: Amputation, Surgical; Animals; DNA-Binding Proteins; Early Growth Response Protein 1; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Immediate-Early Proteins; Immunohistochemistry; Long-Term Potentiation; Male; Memory; Mice; Mice, Knockout; Neuronal Plasticity; Nociceptors; Pain; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors; Transcription Factors | 2000 |
Noxious stimulation increases glutamate and arginine in the periaqueductal gray matter in rats: a microdialysis study.
Topics: Animals; Arginine; Fixatives; Formaldehyde; Glutamic Acid; Hindlimb; Male; Microdialysis; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Stimulation, Chemical | 2000 |
Role of Ca2+-permeable non-NMDA glutamate receptors in spinal nociceptive transmission.
Topics: Animals; Calcium Channels; Dose-Response Relationship, Drug; Glutamic Acid; Male; Nerve Fibers; Nociceptors; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Spider Venoms; Synaptic Transmission | 2000 |
The anterior pretectal nucleus participates as a relay station in the glutamate-, but not morphine-induced antinociception from the dorsal raphe nucleus in rats.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Basal Ganglia; Glutamic Acid; Lidocaine; Male; Microinjections; Morphine; Naloxone; Narcotic Antagonists; Neural Pathways; Pain; Pain Measurement; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1 | 2000 |
Striatal modulation of the jaw opening reflex.
Topics: Animals; Corpus Striatum; Dental Pulp; Electric Stimulation; Glutamic Acid; Jaw; Male; Muscle, Skeletal; Neural Inhibition; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Reflex | 2001 |
Antinociceptive properties of N-aryl-glutaramic acids and N-aryl-glutarimides.
Topics: Acetic Acid; Analgesics; Aspirin; Chromatography, Thin Layer; Formaldehyde; Glutamic Acid; Humans; Indomethacin; Magnetic Resonance Spectroscopy; Muscle Contraction; Pain; Pain Measurement; Piperidones; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 2000 |
A chemomechanical method for caries removal.
Topics: Dental Caries; Dental Cavity Preparation; Dental Pulp; Dental Restoration, Permanent; Dentin; Glutamic Acid; Humans; Leucine; Lysine; Pain; Patient Satisfaction | 2000 |
Intrathecal magnesium sulfate attenuates algogenic behavior and spinal amino acids release after kainic acid receptor activation in rats.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Calcium Channel Blockers; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Kainic Acid; Magnesium Sulfate; Male; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Taurine | 2001 |
Characterization of the glutamatergic system for induction and maintenance of allodynia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; ATP-Binding Cassette Transporters; Capsaicin; Dinoprost; Dinoprostone; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Receptors, Glutamate; Synapses; Synaptic Transmission; Touch | 2001 |
Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation.
Topics: Animals; Dinoprostone; Glutamic Acid; Glycerol; Lactic Acid; Male; Microdialysis; Nitrates; Nitric Oxide; Nitrites; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Zymosan | 2001 |
Cholinergic, noradrenergic, and serotonergic inhibition of fast synaptic transmission in spinal lumbar dorsal horn of rat.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brain Stem; Efferent Pathways; Excitatory Postsynaptic Potentials; Glutamic Acid; Lumbar Vertebrae; Muscarinic Agonists; Neural Inhibition; Neurotransmitter Agents; Nociceptors; Norepinephrine; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists; Spinal Nerve Roots; Synapses; Synaptic Transmission | 2001 |
A-fiber sensory input induces neuronal cell death in the dorsal horn of the adult rat spinal cord.
Topics: Afferent Pathways; Animals; Cell Count; Cell Death; Electric Stimulation; Glutamic Acid; Male; Microscopy, Electron; Nerve Fibers, Myelinated; Neuronal Plasticity; Pain; Peripheral Nervous System Diseases; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Synaptic Transmission | 2001 |
Differential contributions of NMDA and non-NMDA receptors to spinal Fos expression evoked by superficial tissue and muscle inflammation in the rat.
Topics: Afferent Pathways; Animals; Cell Count; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Immunohistochemistry; Inflammation; Male; Muscle, Skeletal; Nociceptors; Pain; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Skin; Synaptic Transmission; Turpentine; Valine | 2001 |
Physiological characteristics of the projection pathway from the medial preoptic to the nucleus raphe magnus of the rat and its modulation by the periaqueductal gray.
Topics: Anesthetics, Local; Animals; Electric Stimulation; Glutamic Acid; Lidocaine; Male; Neural Pathways; Neurons; Pain; Periaqueductal Gray; Preoptic Area; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2001 |
Glutamate and GABA: a painful combination.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Pain; Posterior Horn Cells; Receptors, Kainic Acid | 2001 |
Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit.
Topics: Acute Disease; Animals; Central Nervous System; Electric Stimulation; Female; Glutamic Acid; Heterozygote; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Reaction Time; Receptors, N-Methyl-D-Aspartate; Reflex; Synaptic Transmission | 2001 |
Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Foot; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Nociceptors; Pain; Pain Measurement; Receptors, Glutamate; Receptors, Neurokinin-1; Spinal Cord; Substance P; Synaptic Transmission | 2001 |
Involvement of capsaicin-sensitive fibers in spinal NMDA-induced glutamate release.
Topics: Animals; Animals, Newborn; Capsaicin; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Lumbar Vertebrae; Male; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2001 |
Involvement of spinal N-methyl-D-aspartate receptors in capsaicin-induced in vivo release of substance P in the rat dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microdialysis; Nerve Fibers; Nociceptors; Pain; Posterior Horn Cells; Quinoxalines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substance P; Synapses; Synaptic Transmission | 2001 |
Extracellular glutamate, aspartate and arginine increase in the ventral posterolateral thalamic nucleus during nociceptive stimulation.
Topics: Amino Acids; Animals; Arginine; Aspartic Acid; Electrophoresis, Capillary; Extracellular Space; Glutamic Acid; Male; Microdialysis; Nociceptors; Pain; Pain Measurement; Rats; Rats, Wistar; Synaptic Transmission; Ventral Thalamic Nuclei | 2001 |
Sensitization of glutamate release and N-methyl-D-aspartate receptor response by transient dopamine pretreatment in prefrontal cortex of rats.
Topics: Animals; Avoidance Learning; Calcium Signaling; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Agonists; Glutamic Acid; Habituation, Psychophysiologic; Immobilization; Memory; Microdialysis; Microscopy, Video; N-Methylaspartate; Pain; Perfusion; Prefrontal Cortex; Rats; Receptors, N-Methyl-D-Aspartate; Reserpine; Septum Pellucidum; Stress, Physiological; Synaptic Transmission; Tetrodotoxin | 2002 |
Neurochemistry of superficial spinal neurones projecting to nucleus of the solitary tract that express c-fos on chemical somatic and visceral nociceptive input in the rat.
Topics: Afferent Pathways; Animals; Calbindin 1; Calbindins; Drosophila Proteins; Fluorescent Antibody Technique; Glutamic Acid; Immunohistochemistry; Insect Proteins; Male; Pain; Peripheral Nerves; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA-Binding Proteins; S100 Calcium Binding Protein G; Solitary Nucleus | 2001 |
The effects of Zn2+ on long-term potentiation of C fiber-evoked potentials in the rat spinal dorsal horn.
Topics: Afferent Pathways; Animals; Electric Stimulation; Evoked Potentials; Glutamic Acid; Long-Term Potentiation; Male; Nerve Fibers; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Synapses; Synaptic Transmission; Zinc | 2001 |
Glutamate-induced sensitization of rat masseter muscle fibers.
Topics: Action Potentials; Afferent Pathways; Animals; Electric Stimulation; Female; Glutamic Acid; Male; Masseter Muscle; Mechanoreceptors; Nerve Fibers, Myelinated; Neural Conduction; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Proprioception; Rats; Rats, Sprague-Dawley; Reaction Time; Synaptic Transmission | 2002 |
Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Carboxypeptidases; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Glutamic Acid; Injections, Intravenous; Male; Neurons, Afferent; Neuroprotective Agents; Organophosphorus Compounds; Pain; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy | 2002 |
Increased nitric oxide release by transient peripheral noxious inputs to the spinal cord of rats: an in vivo voltammetric approach.
Topics: Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Neural Conduction; Nitric Oxide; Nociceptors; Oxidation-Reduction; Pain; Peripheral Nerves; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Up-Regulation | 2002 |
Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicin.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Capsaicin; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Glutamic Acid; Nerve Fibers; Nerve Fibers, Myelinated; Neural Conduction; Nociceptors; Pain; Polyunsaturated Alkamides; Rats; Substantia Gelatinosa; Synaptic Transmission | 2002 |
Spinal inhibitory effects of cardiopulmonary afferent inputs in monkeys: neuronal processing in high cervical segments.
Topics: Animals; Cervical Vertebrae; Electrophysiology; Glutamic Acid; Heart; Lumbosacral Region; Lung; Macaca fascicularis; Male; Neural Inhibition; Neurons, Afferent; Pain; Spinal Cord; Stellate Ganglion; Stimulation, Chemical; Vagus Nerve | 2002 |
Facilitation and attenuation of a visceral nociceptive reflex from the rostroventral medulla in the rat.
Topics: Animals; Catheterization; Colon; Efferent Pathways; Electric Stimulation; Electromyography; Glutamic Acid; Male; Medulla Oblongata; Neural Inhibition; Nociceptors; Pain; Peritoneum; Rats; Rats, Sprague-Dawley; Reaction Time; Rectum; Reflex; Spinal Cord; Stimulation, Chemical | 2002 |
Effect of ionotropic glutamate receptor antagonists on Fos-like immunoreactivity in the dorsal horn following transection of the rat sciatic nerve.
Topics: Afferent Pathways; Animals; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Glutamic Acid; Immunohistochemistry; Male; Nerve Crush; Nociceptors; Pain; Peripheral Nervous System Diseases; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Synaptic Transmission; Up-Regulation | 2002 |
Cellular basis for the effects of substance P in the periaqueductal gray and dorsal raphe nucleus.
Topics: Animals; Anxiety; Dendrites; Enkephalins; Glutamic Acid; Immunohistochemistry; Male; Microscopy, Electron; Neurons; Pain; Periaqueductal Gray; Presynaptic Terminals; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Serotonin; Substance P; Synaptic Transmission; Tryptophan Hydroxylase | 2002 |
Glutamate-induced currents reveal three functionally distinct NMDA receptor populations in rat dorsal horn - effects of peripheral nerve lesion and inflammation.
Topics: Animals; Cell Culture Techniques; Electrophysiology; Freund's Adjuvant; Glutamic Acid; Inflammation; Male; Pain; Patch-Clamp Techniques; Peripheral Nerve Injuries; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2002 |
The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Mapping; Brain Stem; Diencephalon; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Medulla Oblongata; Mesencephalon; Microinjections; N-Methylaspartate; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Reticular Formation; Stereotaxic Techniques | 1992 |
Brainstem excitatory amino acid receptors in nociception: microinjection mapping and pharmacological characterization of glutamate-sensitive sites in the brainstem associated with algogenic behavior.
Topics: Animals; Brain Mapping; Brain Stem; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Male; Microinjections; Nociceptors; Pain; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thalamus | 1992 |
Role of the deep mesencephalic nucleus in the antinociception induced by stimulation of the anterior pretectal nucleus in rats.
Topics: Animals; Electric Stimulation; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Mesencephalon; Microinjections; Pain; Rats; Rats, Inbred Strains; Reflex; Tail | 1992 |
Glutamate-immunoreactive terminals synapse on primate spinothalamic tract cells.
Topics: Animals; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Immunohistochemistry; Macaca fascicularis; Nerve Endings; Pain; Spinothalamic Tracts; Synapses | 1992 |
Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Electric Stimulation; Glutamates; Glutamic Acid; Glycine; Injections, Spinal; Male; Pain; Peripheral Nerve Injuries; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Strychnine | 1991 |
Inhibition of rubral neurons by noxious and non-noxious pressure.
Topics: Animals; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hindlimb; Ibotenic Acid; Male; Microinjections; Morphine; Neurons; Oxotremorine; Pain; Pressure; Rats; Rats, Inbred Strains; Red Nucleus; Serotonin; Tail | 1991 |
The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat.
Topics: Animals; Axons; Bombesin; Cats; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Hot Temperature; Kinetics; Neurokinin A; Neurons; Pain; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Spinal Cord; Substance P | 1990 |
Interactions between substance P, calcitonin gene-related peptide, taurine and excitatory amino acids in the spinal cord.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Drug Interactions; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Pain; Pain Measurement; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Self Mutilation; Spinal Cord; Substance P; Taurine | 1990 |
Projections from the periaqueductal gray to the rostromedial pericoerulear region and nucleus locus coeruleus: anatomic and physiologic studies.
Topics: Afferent Pathways; Animals; Axonal Transport; Brain Mapping; Evoked Potentials; Glutamates; Glutamic Acid; Horseradish Peroxidase; Locus Coeruleus; Male; Medulla Oblongata; Neurons; Norepinephrine; Pain; Periaqueductal Gray; Rats; Rats, Inbred Strains; Synapses; Tegmentum Mesencephali; Wheat Germ Agglutinins | 1991 |
Characterization of descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat.
Topics: Animals; Cardiovascular Physiological Phenomena; Efferent Pathways; Electric Stimulation; Glutamates; Glutamic Acid; Male; Medulla Oblongata; Microinjections; Neural Inhibition; Pain; Rats; Rats, Inbred Strains; Reflex; Tail | 1990 |
Spinal cholinergic and monoaminergic receptors mediate descending inhibition from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat.
Topics: Animals; Blood Pressure; Electric Stimulation; Glutamates; Glutamic Acid; Injections, Spinal; Male; Medulla Oblongata; Microinjections; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Cholinergic; Receptors, Neurotransmitter; Spinal Cord | 1990 |
Is substance P a primary afferent neurotransmitter for nociceptive input? II. Spinalization does not reduce and intrathecal morphine potentiates behavioral responses to substance P.
Topics: Animals; Decerebrate State; Drug Interactions; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P | 1988 |
Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from intrathecal administration of substance P and 6 excitatory compounds.
Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P | 1988 |
Behavior induced by putative nociceptive neurotransmitters is inhibited by adenosine or adenosine analogs coadministered intrathecally.
Topics: Adenosine; Animals; Aspartic Acid; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Spinal; Male; Mice; N-Methylaspartate; Neurotransmitter Agents; Pain; Substance P | 1988 |
Comparison of the antinociceptive effect of morphine and glutamate at coincidental sites in the periaqueductal gray and medial medulla in rats.
Topics: Analgesics; Animals; Glutamates; Glutamic Acid; Male; Medulla Oblongata; Microinjections; Morphine; Nociceptors; Pain; Periaqueductal Gray; Rats; Rats, Inbred Strains | 1989 |
Relationship between cardiovascular neurones and descending antinociceptive pathways in the rostral ventrolateral medulla of the cat.
Topics: Action Potentials; Animals; Cardiovascular System; Cats; Glutamates; Glutamic Acid; Medulla Oblongata; Pain; Periaqueductal Gray; Raphe Nuclei | 1989 |
Characterization of coeruleospinal inhibition of the nociceptive tail-flick reflex in the rat: mediation by spinal alpha 2-adrenoceptors.
Topics: Adrenergic Fibers; Animals; Efferent Pathways; Glutamates; Glutamic Acid; Locus Coeruleus; Male; Pain; Pons; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reflex; Spinal Cord | 1986 |
Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats.
Topics: Animals; Aspartic Acid; Brain Chemistry; Dextroamphetamine; Glutamates; Glutamic Acid; Male; Pain; Rats; Stress, Physiological | 1986 |
Spinal monoamine mediation of stimulation-produced antinociception from the lateral hypothalamus.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Brain Mapping; Catecholamines; Electric Stimulation; Glutamates; Glutamic Acid; Hypothalamic Area, Lateral; Injections, Spinal; Male; Nociceptors; Pain; Rats; Rats, Inbred Strains; Reflex; Spinal Cord | 1987 |
Dissociation of antinociceptive from cardiovascular effects of stimulation in the lateral reticular nucleus in the rat.
Topics: Animals; Blood Pressure; Brain Mapping; Cardiovascular Physiological Phenomena; Electric Stimulation; Glutamates; Glutamic Acid; Male; Medulla Oblongata; Pain; Rats; Rats, Inbred Strains; Reticular Formation; Vascular Resistance | 1987 |
Spinal monoaminergic receptors mediate the antinociception produced by glutamate in the medullary lateral reticular nucleus.
Topics: Animals; Electric Stimulation; Glutamates; Glutamic Acid; Hot Temperature; Male; Methysergide; Microinjections; Naloxone; Nociceptors; Pain; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Reticular Formation; Yohimbine | 1987 |
[Effects of exciting the habenula by L-glutamic acid on the pain threshold and acupuncture analgesia].
Topics: Acupuncture Therapy; Animals; Electric Stimulation Therapy; Female; Glutamates; Glutamic Acid; Male; Microinjections; Pain; Pain Measurement; Rats; Sensory Thresholds; Thalamic Nuclei; Transcutaneous Electric Nerve Stimulation | 1987 |
Quantitative characterization and spinal pathway mediating inhibition of spinal nociceptive transmission from the lateral reticular nucleus in the rat.
Topics: Animals; Electric Stimulation; Functional Laterality; Glutamates; Glutamic Acid; Male; Neural Inhibition; Neural Pathways; Nociceptors; Pain; Rats; Rats, Inbred Strains; Reticular Formation; Sodium Glutamate; Spinal Cord | 1988 |
The antinociceptive role of a bulbospinal serotonergic pathway in the rat brain.
Topics: 5,7-Dihydroxytryptamine; Analgesia; Animals; Electric Stimulation; Glutamates; Glutamic Acid; Kainic Acid; Male; Medulla Oblongata; Neural Pathways; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Serotonin; Spinal Cord | 1988 |
Endogenous GABA released into the fourth ventricle of the rat brain in vivo is enhanced by noxious stimuli.
Topics: Animals; Cerebral Ventricles; Formaldehyde; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; Pain; Rats; Rats, Inbred Strains | 1988 |
[Effects of nucleus raphe magnus and locus coeruleus in descending modulation of the habenula on pain threshold and acupuncture analgesia].
Topics: Acupuncture Therapy; Analgesia; Animals; Efferent Pathways; Electric Stimulation; Female; Glutamates; Glutamic Acid; Lidocaine; Locus Coeruleus; Male; Pain; Raphe Nuclei; Rats; Sensory Thresholds; Thalamic Nuclei | 1988 |
Microinjections of glutamate or morphine at coincident midbrain sites have different effects on nociceptive dorsal horn neurons in the rat.
Topics: Animals; Efferent Pathways; Electric Stimulation; Glutamates; Glutamic Acid; Mesencephalon; Microinjections; Morphine; Nociceptors; Pain; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reticular Formation; Spinal Cord | 1988 |
[The influence of blocking habenulae or medial forebrain bundles on the analgesic effect elicited by administration L-glutamic acid into the septa].
Topics: Analgesia; Animals; Female; Glutamates; Glutamic Acid; Lidocaine; Male; Medial Forebrain Bundle; Neural Pathways; Pain; Rats; Sensory Thresholds; Septal Nuclei; Thalamic Nuclei | 1988 |