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gentamicin and Plague

gentamicin has been researched along with Plague in 18 studies

Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.

Plague: An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form.

Research Excerpts

ExcerptRelevanceReference
"Both gentamicin and doxycycline were effective therapies for adult and pediatric plague, with high rates of favorable responses and low rates of adverse events."9.12Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania. ( Almasi, Y; Bradley, C; Butler, T; Formanik, JB; Mgema, S; Mhina, G; Mwengee, W; Rochester, CG, 2006)
"Streptomycin, an antimicrobial with limited availability, is the treatment of choice for plague, a fulminating and potentially epidemic disease that poses a bioterrorism concern."7.72Gentamicin and tetracyclines for the treatment of human plague: review of 75 cases in new Mexico, 1985-1999. ( Boulanger, LL; Dennis, DT; Ettestad, P; Fogarty, JD; Mertz, G; Romig, D, 2004)
"Activity of aminoglycosides such as gentamicin, sisomicin and amikacin against plague microbe strains of natural origin was studied in vitro."7.68[Antibiotics of the aminoglycoside group (gentamicin, sisomicin and amikacin) in the prevention and treatment of experimental plague]. ( Bugaeva, OK; Kasatkina, IV; Makarovskaia, LN; Shcherbaniuk, AI, 1992)
"Both gentamicin and doxycycline were effective therapies for adult and pediatric plague, with high rates of favorable responses and low rates of adverse events."5.12Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania. ( Almasi, Y; Bradley, C; Butler, T; Formanik, JB; Mgema, S; Mhina, G; Mwengee, W; Rochester, CG, 2006)
" We explored the effects of neutropenia on the outcome of doxycycline and gentamicin therapy."3.74Comparison of 2 antibiotics that inhibit protein synthesis for the treatment of infection with Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague. ( Bassett, J; Drusano, GL; Heine, HS; Kinzig-Schippers, M; Louie, A; Miller, L; Sorgel, F; Sullivan, LJ, 2007)
"Streptomycin, an antimicrobial with limited availability, is the treatment of choice for plague, a fulminating and potentially epidemic disease that poses a bioterrorism concern."3.72Gentamicin and tetracyclines for the treatment of human plague: review of 75 cases in new Mexico, 1985-1999. ( Boulanger, LL; Dennis, DT; Ettestad, P; Fogarty, JD; Mertz, G; Romig, D, 2004)
"Activity of aminoglycosides such as gentamicin, sisomicin and amikacin against plague microbe strains of natural origin was studied in vitro."3.68[Antibiotics of the aminoglycoside group (gentamicin, sisomicin and amikacin) in the prevention and treatment of experimental plague]. ( Bugaeva, OK; Kasatkina, IV; Makarovskaia, LN; Shcherbaniuk, AI, 1992)
"The effect of various antibiotics, such as streptomycin, gentamicin, ampicillin, benzylpenicillin, tetracycline, chlortetracycline and levomycetin on the plague bacteria (strain Y."3.65[Effect of several antibiotics and their combination with prodigiozan on Y. pestis EV, engulfed by macrophages]. ( Makarovskaia, LN; Mikhalevich, RV; Popova, GO; Sokolova, MT; Vinidchenko, NN, 1977)
"Gentamicin use was associated with higher mortality than streptomycin, and aminoglycoside use was linked to higher mortality than for tetracyclines."1.56Antimicrobial Treatment Patterns and Illness Outcome Among United States Patients With Plague, 1942-2018. ( Campbell, SB; Kugeler, KJ; Mead, PS; Nelson, CA, 2020)
"Plague is a life-threatening disease caused by the bacterium, Yersinia pestis."1.48Mixed pneumonic plague and nosocomial MDR-bacterial infection of lung: a rare case report. ( Andrianaivoarimanana, V; Bertherat, E; Rajaonarison, R; Rajerison, M; Rakotondramaro, T; Rogier, C, 2018)
"pestis CO92 to evoke pneumonic plague in a mouse model while retaining the required immunogenicity needed for subsequent protection against infection."1.42Combinational deletion of three membrane protein-encoding genes highly attenuates yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague. ( Andersson, JA; Baze, WB; Chauhan, S; Chopra, AK; Erova, TE; Kirtley, ML; Motin, VL; Ponnusamy, D; Popov, VL; Sha, J; Tiner, BL; van Lier, CJ, 2015)
"The signs of pneumonic plague in sacred baboons infected by aerosol are: fever, hurried breathing, depression and constantly increasing bacteremia."1.29[Standardization of conditions for the evaluation of effectiveness of antibacterial drugs in pneumonic plague in sacred baboons]. ( Mironin, AV; Paramonov, VE; Romanov, VE; Shabalin, BA; Vasil'ev, NT, 1995)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19903 (16.67)18.7374
1990's3 (16.67)18.2507
2000's6 (33.33)29.6817
2010's5 (27.78)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Kugeler, KJ1
Mead, PS1
Campbell, SB1
Nelson, CA1
Andrianaivoarimanana, V1
Bertherat, E1
Rajaonarison, R1
Rakotondramaro, T1
Rogier, C1
Rajerison, M1
Tiner, BL1
Sha, J2
Kirtley, ML2
Erova, TE2
Popov, VL1
Baze, WB1
van Lier, CJ2
Ponnusamy, D2
Andersson, JA1
Motin, VL1
Chauhan, S1
Chopra, AK2
Wendte, JM1
Reiber, D1
Blair, JL1
Clinkenbeard, KD1
Wang, S1
Kozlova, EV1
Cao, A1
Cong, Y1
Fitts, EC1
Rosenzweig, JA1
Lemaître, N1
Ricard, I1
Pradel, E1
Foligné, B1
Courcol, R1
Simonet, M1
Sebbane, F1
Kamiyama, T1
Enserink, M1
Boulanger, LL1
Ettestad, P1
Fogarty, JD1
Dennis, DT1
Romig, D1
Mertz, G1
Mwengee, W1
Butler, T1
Mgema, S1
Mhina, G1
Almasi, Y1
Bradley, C1
Formanik, JB1
Rochester, CG1
Smorodinova, IuV1
Shcherbaniuk, AI2
Ryzhko, IV1
Moldavan, IA1
Heine, HS1
Louie, A1
Sorgel, F1
Bassett, J1
Miller, L1
Sullivan, LJ1
Kinzig-Schippers, M1
Drusano, GL1
Romanov, VE1
Vasil'ev, NT1
Shabalin, BA1
Mironin, AV1
Paramonov, VE1
Ryzhkova, VV1
Pavlovich, NV1
Makarovskaia, LN3
Zurabian, VA1
Bespalova, IA1
Goncharov, EK1
Bugaeva, OK2
Malsova, NN1
Popova, GO1
Vinidchenko, NN1
Mikhalevich, RV1
Sokolova, MT1
von Reyn, CF1
Barnes, AM1
Weber, NS1
Quan, T1
Dean, WJ1
Kasatkina, IV1
Welty, TK1

Reviews

1 review available for gentamicin and Plague

ArticleYear
[Plague].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 2

    Topics: Animals; Anti-Bacterial Agents; Antigens, Bacterial; Bacterial Proteins; Chloramphenicol; Diagnosis,

2003

Trials

1 trial available for gentamicin and Plague

ArticleYear
Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, Mar-01, Volume: 42, Issue:5

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Child, Preschool; Doxycycline; Female; Gentam

2006

Other Studies

16 other studies available for gentamicin and Plague

ArticleYear
Antimicrobial Treatment Patterns and Illness Outcome Among United States Patients With Plague, 1942-2018.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020, 05-21, Volume: 70, Issue:70 Suppl 1

    Topics: Anti-Bacterial Agents; Gentamicins; Humans; Plague; Tetracyclines; United States; Yersinia pestis

2020
Mixed pneumonic plague and nosocomial MDR-bacterial infection of lung: a rare case report.
    BMC pulmonary medicine, 2018, May-29, Volume: 18, Issue:1

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Coinfection; Cross Infection; Drug Resistance, Multiple, Bacte

2018
Combinational deletion of three membrane protein-encoding genes highly attenuates yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague.
    Infection and immunity, 2015, Volume: 83, Issue:4

    Topics: Acyltransferases; Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Bacterial Adhesion; Bacteri

2015
In vitro efficacy of antibiotics commonly used to treat human plague against intracellular Yersinia pestis.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:8

    Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Cell Line; Chloramphenicol; Ciprofloxacin; Doxycycline;

2011
Deletion of the Braun lipoprotein-encoding gene and altering the function of lipopolysaccharide attenuate the plague bacterium.
    Infection and immunity, 2013, Volume: 81, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Female; Gene Deletion; Gene Expression Regulation, Bacterial; Gentam

2013
Efficacy of ciprofloxacin-gentamicin combination therapy in murine bubonic plague.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Bacterial Load; Ciprofloxacin; Drug Therapy, Combination; Female; Ge

2012
Scientific community. African study raises ethical issues.
    Science (New York, N.Y.), 2003, Dec-19, Volume: 302, Issue:5653

    Topics: Anti-Bacterial Agents; Bioterrorism; Clinical Trials as Topic; Doxycycline; Ethics Committees, Resea

2003
Gentamicin and tetracyclines for the treatment of human plague: review of 75 cases in new Mexico, 1985-1999.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004, Mar-01, Volume: 38, Issue:5

    Topics: Adult; Drug Therapy, Combination; Female; Gentamicins; Humans; Length of Stay; Male; Plague; Retrosp

2004
[Isepamycin in prophylaxis and treatment of experimental plague due to FI+ and FI- variants of plague microbe].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2005, Volume: 50, Issue:8-9

    Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Bacterial Proteins; Gentamicins; Mice; Mice, Inbred

2005
Comparison of 2 antibiotics that inhibit protein synthesis for the treatment of infection with Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague.
    The Journal of infectious diseases, 2007, Sep-01, Volume: 196, Issue:5

    Topics: Aerosols; Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Doxycycline; Female; Gen

2007
[Standardization of conditions for the evaluation of effectiveness of antibacterial drugs in pneumonic plague in sacred baboons].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1995, Volume: 40, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Body Temperature Regulation; Ciprofloxacin; D

1995
[Increased effectiveness of etiotropic therapy of experimental plague in albino mice at the stage of generalized infection].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1996, Volume: 41, Issue:2

    Topics: Amikacin; Animals; Anti-Infective Agents; Ciprofloxacin; Disease Progression; Drug Evaluation, Precl

1996
[Effect of several antibiotics and their combination with prodigiozan on Y. pestis EV, engulfed by macrophages].
    Antibiotiki, 1977, Volume: 22, Issue:4

    Topics: Ampicillin; Animals; Anti-Bacterial Agents; Chloramphenicol; Chlortetracycline; Drug Combinations; G

1977
Bubonic plague from direct exposure to a naturally infected wild coyote.
    The American journal of tropical medicine and hygiene, 1976, Volume: 25, Issue:4

    Topics: Ampicillin; Animals; Carnivora; Child; Gentamicins; Humans; Male; Meningitis; New Mexico; Plague; Su

1976
[Antibiotics of the aminoglycoside group (gentamicin, sisomicin and amikacin) in the prevention and treatment of experimental plague].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1992, Volume: 37, Issue:5

    Topics: Amikacin; Animals; Culture Media; Disease Models, Animal; Drug Evaluation, Preclinical; Gentamicins;

1992
Plague.
    American family physician, 1986, Volume: 33, Issue:6

    Topics: Anti-Bacterial Agents; Chloramphenicol; Gentamicins; Humans; Plague; Streptomycin; Tetracycline

1986
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