gentamicin and Plague
gentamicin has been researched along with Plague in 18 studies
Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Plague: An acute infectious disease caused by YERSINIA PESTIS that affects humans, wild rodents, and their ectoparasites. This condition persists due to its firm entrenchment in sylvatic rodent-flea ecosystems throughout the world. Bubonic plague is the most common form.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Both gentamicin and doxycycline were effective therapies for adult and pediatric plague, with high rates of favorable responses and low rates of adverse events." | 9.12 | Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania. ( Almasi, Y; Bradley, C; Butler, T; Formanik, JB; Mgema, S; Mhina, G; Mwengee, W; Rochester, CG, 2006) |
"Streptomycin, an antimicrobial with limited availability, is the treatment of choice for plague, a fulminating and potentially epidemic disease that poses a bioterrorism concern." | 7.72 | Gentamicin and tetracyclines for the treatment of human plague: review of 75 cases in new Mexico, 1985-1999. ( Boulanger, LL; Dennis, DT; Ettestad, P; Fogarty, JD; Mertz, G; Romig, D, 2004) |
"Activity of aminoglycosides such as gentamicin, sisomicin and amikacin against plague microbe strains of natural origin was studied in vitro." | 7.68 | [Antibiotics of the aminoglycoside group (gentamicin, sisomicin and amikacin) in the prevention and treatment of experimental plague]. ( Bugaeva, OK; Kasatkina, IV; Makarovskaia, LN; Shcherbaniuk, AI, 1992) |
"Both gentamicin and doxycycline were effective therapies for adult and pediatric plague, with high rates of favorable responses and low rates of adverse events." | 5.12 | Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania. ( Almasi, Y; Bradley, C; Butler, T; Formanik, JB; Mgema, S; Mhina, G; Mwengee, W; Rochester, CG, 2006) |
" We explored the effects of neutropenia on the outcome of doxycycline and gentamicin therapy." | 3.74 | Comparison of 2 antibiotics that inhibit protein synthesis for the treatment of infection with Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague. ( Bassett, J; Drusano, GL; Heine, HS; Kinzig-Schippers, M; Louie, A; Miller, L; Sorgel, F; Sullivan, LJ, 2007) |
"Streptomycin, an antimicrobial with limited availability, is the treatment of choice for plague, a fulminating and potentially epidemic disease that poses a bioterrorism concern." | 3.72 | Gentamicin and tetracyclines for the treatment of human plague: review of 75 cases in new Mexico, 1985-1999. ( Boulanger, LL; Dennis, DT; Ettestad, P; Fogarty, JD; Mertz, G; Romig, D, 2004) |
"Activity of aminoglycosides such as gentamicin, sisomicin and amikacin against plague microbe strains of natural origin was studied in vitro." | 3.68 | [Antibiotics of the aminoglycoside group (gentamicin, sisomicin and amikacin) in the prevention and treatment of experimental plague]. ( Bugaeva, OK; Kasatkina, IV; Makarovskaia, LN; Shcherbaniuk, AI, 1992) |
"The effect of various antibiotics, such as streptomycin, gentamicin, ampicillin, benzylpenicillin, tetracycline, chlortetracycline and levomycetin on the plague bacteria (strain Y." | 3.65 | [Effect of several antibiotics and their combination with prodigiozan on Y. pestis EV, engulfed by macrophages]. ( Makarovskaia, LN; Mikhalevich, RV; Popova, GO; Sokolova, MT; Vinidchenko, NN, 1977) |
"Gentamicin use was associated with higher mortality than streptomycin, and aminoglycoside use was linked to higher mortality than for tetracyclines." | 1.56 | Antimicrobial Treatment Patterns and Illness Outcome Among United States Patients With Plague, 1942-2018. ( Campbell, SB; Kugeler, KJ; Mead, PS; Nelson, CA, 2020) |
"Plague is a life-threatening disease caused by the bacterium, Yersinia pestis." | 1.48 | Mixed pneumonic plague and nosocomial MDR-bacterial infection of lung: a rare case report. ( Andrianaivoarimanana, V; Bertherat, E; Rajaonarison, R; Rajerison, M; Rakotondramaro, T; Rogier, C, 2018) |
"pestis CO92 to evoke pneumonic plague in a mouse model while retaining the required immunogenicity needed for subsequent protection against infection." | 1.42 | Combinational deletion of three membrane protein-encoding genes highly attenuates yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague. ( Andersson, JA; Baze, WB; Chauhan, S; Chopra, AK; Erova, TE; Kirtley, ML; Motin, VL; Ponnusamy, D; Popov, VL; Sha, J; Tiner, BL; van Lier, CJ, 2015) |
"The signs of pneumonic plague in sacred baboons infected by aerosol are: fever, hurried breathing, depression and constantly increasing bacteremia." | 1.29 | [Standardization of conditions for the evaluation of effectiveness of antibacterial drugs in pneumonic plague in sacred baboons]. ( Mironin, AV; Paramonov, VE; Romanov, VE; Shabalin, BA; Vasil'ev, NT, 1995) |
Research
Studies (18)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (16.67) | 18.7374 |
1990's | 3 (16.67) | 18.2507 |
2000's | 6 (33.33) | 29.6817 |
2010's | 5 (27.78) | 24.3611 |
2020's | 1 (5.56) | 2.80 |
Authors
Authors | Studies |
---|---|
Kugeler, KJ | 1 |
Mead, PS | 1 |
Campbell, SB | 1 |
Nelson, CA | 1 |
Andrianaivoarimanana, V | 1 |
Bertherat, E | 1 |
Rajaonarison, R | 1 |
Rakotondramaro, T | 1 |
Rogier, C | 1 |
Rajerison, M | 1 |
Tiner, BL | 1 |
Sha, J | 2 |
Kirtley, ML | 2 |
Erova, TE | 2 |
Popov, VL | 1 |
Baze, WB | 1 |
van Lier, CJ | 2 |
Ponnusamy, D | 2 |
Andersson, JA | 1 |
Motin, VL | 1 |
Chauhan, S | 1 |
Chopra, AK | 2 |
Wendte, JM | 1 |
Reiber, D | 1 |
Blair, JL | 1 |
Clinkenbeard, KD | 1 |
Wang, S | 1 |
Kozlova, EV | 1 |
Cao, A | 1 |
Cong, Y | 1 |
Fitts, EC | 1 |
Rosenzweig, JA | 1 |
Lemaître, N | 1 |
Ricard, I | 1 |
Pradel, E | 1 |
Foligné, B | 1 |
Courcol, R | 1 |
Simonet, M | 1 |
Sebbane, F | 1 |
Kamiyama, T | 1 |
Enserink, M | 1 |
Boulanger, LL | 1 |
Ettestad, P | 1 |
Fogarty, JD | 1 |
Dennis, DT | 1 |
Romig, D | 1 |
Mertz, G | 1 |
Mwengee, W | 1 |
Butler, T | 1 |
Mgema, S | 1 |
Mhina, G | 1 |
Almasi, Y | 1 |
Bradley, C | 1 |
Formanik, JB | 1 |
Rochester, CG | 1 |
Smorodinova, IuV | 1 |
Shcherbaniuk, AI | 2 |
Ryzhko, IV | 1 |
Moldavan, IA | 1 |
Heine, HS | 1 |
Louie, A | 1 |
Sorgel, F | 1 |
Bassett, J | 1 |
Miller, L | 1 |
Sullivan, LJ | 1 |
Kinzig-Schippers, M | 1 |
Drusano, GL | 1 |
Romanov, VE | 1 |
Vasil'ev, NT | 1 |
Shabalin, BA | 1 |
Mironin, AV | 1 |
Paramonov, VE | 1 |
Ryzhkova, VV | 1 |
Pavlovich, NV | 1 |
Makarovskaia, LN | 3 |
Zurabian, VA | 1 |
Bespalova, IA | 1 |
Goncharov, EK | 1 |
Bugaeva, OK | 2 |
Malsova, NN | 1 |
Popova, GO | 1 |
Vinidchenko, NN | 1 |
Mikhalevich, RV | 1 |
Sokolova, MT | 1 |
von Reyn, CF | 1 |
Barnes, AM | 1 |
Weber, NS | 1 |
Quan, T | 1 |
Dean, WJ | 1 |
Kasatkina, IV | 1 |
Welty, TK | 1 |
Reviews
1 review available for gentamicin and Plague
Article | Year |
---|---|
[Plague].
Topics: Animals; Anti-Bacterial Agents; Antigens, Bacterial; Bacterial Proteins; Chloramphenicol; Diagnosis, | 2003 |
Trials
1 trial available for gentamicin and Plague
Article | Year |
---|---|
Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Child, Preschool; Doxycycline; Female; Gentam | 2006 |
Other Studies
16 other studies available for gentamicin and Plague
Article | Year |
---|---|
Antimicrobial Treatment Patterns and Illness Outcome Among United States Patients With Plague, 1942-2018.
Topics: Anti-Bacterial Agents; Gentamicins; Humans; Plague; Tetracyclines; United States; Yersinia pestis | 2020 |
Mixed pneumonic plague and nosocomial MDR-bacterial infection of lung: a rare case report.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Coinfection; Cross Infection; Drug Resistance, Multiple, Bacte | 2018 |
Combinational deletion of three membrane protein-encoding genes highly attenuates yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague.
Topics: Acyltransferases; Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Bacterial Adhesion; Bacteri | 2015 |
In vitro efficacy of antibiotics commonly used to treat human plague against intracellular Yersinia pestis.
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Cell Line; Chloramphenicol; Ciprofloxacin; Doxycycline; | 2011 |
Deletion of the Braun lipoprotein-encoding gene and altering the function of lipopolysaccharide attenuate the plague bacterium.
Topics: Animals; Anti-Bacterial Agents; Female; Gene Deletion; Gene Expression Regulation, Bacterial; Gentam | 2013 |
Efficacy of ciprofloxacin-gentamicin combination therapy in murine bubonic plague.
Topics: Animals; Anti-Infective Agents; Bacterial Load; Ciprofloxacin; Drug Therapy, Combination; Female; Ge | 2012 |
Scientific community. African study raises ethical issues.
Topics: Anti-Bacterial Agents; Bioterrorism; Clinical Trials as Topic; Doxycycline; Ethics Committees, Resea | 2003 |
Gentamicin and tetracyclines for the treatment of human plague: review of 75 cases in new Mexico, 1985-1999.
Topics: Adult; Drug Therapy, Combination; Female; Gentamicins; Humans; Length of Stay; Male; Plague; Retrosp | 2004 |
[Isepamycin in prophylaxis and treatment of experimental plague due to FI+ and FI- variants of plague microbe].
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Bacterial Proteins; Gentamicins; Mice; Mice, Inbred | 2005 |
Comparison of 2 antibiotics that inhibit protein synthesis for the treatment of infection with Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague.
Topics: Aerosols; Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Doxycycline; Female; Gen | 2007 |
[Standardization of conditions for the evaluation of effectiveness of antibacterial drugs in pneumonic plague in sacred baboons].
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Body Temperature Regulation; Ciprofloxacin; D | 1995 |
[Increased effectiveness of etiotropic therapy of experimental plague in albino mice at the stage of generalized infection].
Topics: Amikacin; Animals; Anti-Infective Agents; Ciprofloxacin; Disease Progression; Drug Evaluation, Precl | 1996 |
[Effect of several antibiotics and their combination with prodigiozan on Y. pestis EV, engulfed by macrophages].
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Chloramphenicol; Chlortetracycline; Drug Combinations; G | 1977 |
Bubonic plague from direct exposure to a naturally infected wild coyote.
Topics: Ampicillin; Animals; Carnivora; Child; Gentamicins; Humans; Male; Meningitis; New Mexico; Plague; Su | 1976 |
[Antibiotics of the aminoglycoside group (gentamicin, sisomicin and amikacin) in the prevention and treatment of experimental plague].
Topics: Amikacin; Animals; Culture Media; Disease Models, Animal; Drug Evaluation, Preclinical; Gentamicins; | 1992 |
Plague.
Topics: Anti-Bacterial Agents; Chloramphenicol; Gentamicins; Humans; Plague; Streptomycin; Tetracycline | 1986 |