gaboxadol has been researched along with Aura in 6 studies
gaboxadol: GABA agonist; inhibitor of GABA uptake systems; structure
Excerpt | Relevance | Reference |
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"Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling." | 7.77 | The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. ( Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J, 2011) |
"The involvement of intranigral gamma-aminobutyric acid (GABA) receptors in the control of generalized non-convulsive epilepsy was investigated in the rat in 3 models of petit mal epilepsy induced by systemic administration of gamma-butyrolactone, pentylenetetrazol and 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin 3-ol (THIP)." | 7.67 | Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents. ( Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M, 1989) |
"Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling." | 3.77 | The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. ( Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J, 2011) |
"The involvement of intranigral gamma-aminobutyric acid (GABA) receptors in the control of generalized non-convulsive epilepsy was investigated in the rat in 3 models of petit mal epilepsy induced by systemic administration of gamma-butyrolactone, pentylenetetrazol and 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin 3-ol (THIP)." | 3.67 | Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents. ( Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M, 1989) |
"Three drugs which increase GABA-mediated inhibitory neurotransmission in the brain, namely the GABA degradation inhibitors aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG), and the GABA receptor agonist THIP (gaboxadol), were administered to epilepsy-prone gerbils via subcutaneously implanted osmotic minipumps for 2 weeks." | 3.67 | Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. ( Löscher, W, 1986) |
" Marked differences in drug sensitivity were observed between models based on single and chronic administration of PTZ showing that the two sets of models are fundamentally different." | 1.32 | Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice. ( Hansen, SL; Sánchez, C; Sperling, BB, 2004) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (50.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (16.67) | 29.6817 |
2010's | 2 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Sun, Y | 1 |
Wu, Z | 1 |
Kong, S | 1 |
Jiang, D | 1 |
Pitre, A | 1 |
Wang, Y | 1 |
Chen, G | 1 |
Gonzalez-Sulser, A | 1 |
Wang, J | 1 |
Motamedi, GK | 1 |
Avoli, M | 1 |
Vicini, S | 1 |
Dzakpasu, R | 1 |
Hansen, SL | 1 |
Sperling, BB | 1 |
Sánchez, C | 1 |
Petersen, HR | 1 |
Jensen, I | 1 |
Dam, M | 1 |
Depaulis, A | 1 |
Snead, OC | 1 |
Marescaux, C | 1 |
Vergnes, M | 1 |
Löscher, W | 1 |
1 trial available for gaboxadol and Aura
Article | Year |
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THIP: a single-blind controlled trial in patients with epilepsy.
Topics: Adult; Anticonvulsants; Drug Evaluation; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Ox | 1983 |
5 other studies available for gaboxadol and Aura
Article | Year |
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Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells | 2013 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Ani | 2011 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-R | 2004 |
Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents.
Topics: 4-Butyrolactone; Animals; Convulsants; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Is | 1989 |
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; D | 1986 |