gabexate and Sepsis
gabexate has been researched along with Sepsis in 4 studies
Gabexate: A serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " We retrospectively evaluated and compared the efficacies of rhTM and gabexate mesilate (GM) in patients diagnosed with sepsis-induced DIC." | 7.80 | A retrospective comparative study of recombinant human thrombomodulin and gabexate mesilate in sepsis-induced disseminated intravascular coagulation patients. ( Imamura, Y; Izumikawa, K; Kohno, S; Matsuo, N; Miyazaki, T; Nakamura, S; Sawai, T; Suyama, N; Takazono, T; Yanagihara, K; Yoshioka, S, 2014) |
| " We retrospectively evaluated and compared the efficacies of rhTM and gabexate mesilate (GM) in patients diagnosed with sepsis-induced DIC." | 3.80 | A retrospective comparative study of recombinant human thrombomodulin and gabexate mesilate in sepsis-induced disseminated intravascular coagulation patients. ( Imamura, Y; Izumikawa, K; Kohno, S; Matsuo, N; Miyazaki, T; Nakamura, S; Sawai, T; Suyama, N; Takazono, T; Yanagihara, K; Yoshioka, S, 2014) |
| "Whereas in DIC associated with trauma, since balance between coagulation and fibrinolysis collapses drastically in a short period, both anticoagulantion therapy and antifibrinolytic therapy can be utilized depending on clinical conditions." | 2.53 | [Anti DIC therapy]. ( Sakamoto, Y; Yahata, M, 2016) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Gando, S | 1 |
| Saitoh, D | 1 |
| Ishikura, H | 1 |
| Ueyama, M | 1 |
| Otomo, Y | 1 |
| Oda, S | 1 |
| Kushimoto, S | 1 |
| Tanjoh, K | 1 |
| Mayumi, T | 1 |
| Ikeda, T | 1 |
| Iba, T | 1 |
| Eguchi, Y | 1 |
| Okamoto, K | 1 |
| Ogura, H | 1 |
| Koseki, K | 1 |
| Sakamoto, Y | 2 |
| Takayama, Y | 1 |
| Shirai, K | 1 |
| Takasu, O | 1 |
| Inoue, Y | 1 |
| Mashiko, K | 1 |
| Tsubota, T | 1 |
| Endo, S | 1 |
| Takazono, T | 1 |
| Nakamura, S | 1 |
| Imamura, Y | 1 |
| Yoshioka, S | 1 |
| Miyazaki, T | 1 |
| Izumikawa, K | 1 |
| Sawai, T | 1 |
| Matsuo, N | 1 |
| Yanagihara, K | 1 |
| Suyama, N | 1 |
| Kohno, S | 1 |
| Akahoshi, T | 1 |
| Sugimori, H | 1 |
| Kaku, N | 1 |
| Tokuda, K | 1 |
| Nagata, T | 1 |
| Noda, E | 1 |
| Morita, M | 1 |
| Hashizume, M | 1 |
| Maehara, Y | 1 |
| Yahata, M | 1 |
Reviews
1 review available for gabexate and Sepsis
| Article | Year |
|---|---|
[Anti DIC therapy].
Topics: Anticoagulants; Antifibrinolytic Agents; Antithrombins; Benzamidines; Disseminated Intravascular Coa | 2016 |
Trials
1 trial available for gabexate and Sepsis
| Article | Year |
|---|---|
A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis.
Topics: Aged; Antithrombins; Blood Coagulation; Disseminated Intravascular Coagulation; Drug Administration | 2013 |
Other Studies
2 other studies available for gabexate and Sepsis
| Article | Year |
|---|---|
A retrospective comparative study of recombinant human thrombomodulin and gabexate mesilate in sepsis-induced disseminated intravascular coagulation patients.
Topics: Aged; Aged, 80 and over; Analysis of Variance; C-Reactive Protein; Disseminated Intravascular Coagul | 2014 |
Comparison of recombinant human thrombomodulin and gabexate mesylate for treatment of disseminated intravascular coagulation (DIC) with sepsis following emergent gastrointestinal surgery: a retrospective study.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Critical Care; Disseminated Intravascular Coagulatio | 2015 |