Page last updated: 2024-10-27

gabapentin and Edema

gabapentin has been researched along with Edema in 14 studies

Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
"In this pooled analysis of adverse-event data from 3 clinical trials in patients with PHN, the incidence of peripheral edema was increased when gabapentin was titrated to >or=1800 mg/d."8.82Gabapentin: a pooled analysis of adverse events from three clinical trials in patients with postherpetic neuralgia. ( Huang, S; Parsons, B; Tive, L, 2004)
"Gabapentinoids are ligands of the α2-δ subunit of voltage-gated calcium channels (Cav) that have been associated with a risk of peripheral edema and acute heart failure in connection with a potentially dual mechanism, vascular and cardiac."8.12Gabapentinoid-induced peripheral edema and acute heart failure: A translational study combining pharmacovigilance data and in vitro animal experiments. ( Auffret, M; Bordy, R; Bredeloux, P; Cracowski, JL; Gras-Champel, V; Jonville-Béra, AP; Largeau, B; Lengellé, C; Maupoil, V; Pasqualin, C, 2022)
" The current study evaluated the pharmacological activity of gabapentin (GBP) and its salicylaldehyde derivative (gabapentsal; [2-(1-(((2-hydroxybenzylidene) amino) methyl) cyclohexyl) acetic acid]; GPS) in well-established mouse models of nociceptive pain, inflammatory edema, and pyrexia at doses of 25-100 mg/kg."8.02Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021)
" When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%)."7.72Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003)
"In this pooled analysis of adverse-event data from 3 clinical trials in patients with PHN, the incidence of peripheral edema was increased when gabapentin was titrated to >or=1800 mg/d."4.82Gabapentin: a pooled analysis of adverse events from three clinical trials in patients with postherpetic neuralgia. ( Huang, S; Parsons, B; Tive, L, 2004)
"Gabapentinoids are ligands of the α2-δ subunit of voltage-gated calcium channels (Cav) that have been associated with a risk of peripheral edema and acute heart failure in connection with a potentially dual mechanism, vascular and cardiac."4.12Gabapentinoid-induced peripheral edema and acute heart failure: A translational study combining pharmacovigilance data and in vitro animal experiments. ( Auffret, M; Bordy, R; Bredeloux, P; Cracowski, JL; Gras-Champel, V; Jonville-Béra, AP; Largeau, B; Lengellé, C; Maupoil, V; Pasqualin, C, 2022)
" The current study evaluated the pharmacological activity of gabapentin (GBP) and its salicylaldehyde derivative (gabapentsal; [2-(1-(((2-hydroxybenzylidene) amino) methyl) cyclohexyl) acetic acid]; GPS) in well-established mouse models of nociceptive pain, inflammatory edema, and pyrexia at doses of 25-100 mg/kg."4.02Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021)
" When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%)."3.72Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003)
"Outcome measures were postsurgical pain at rest and during walking, consumption of opioids for pain rescue, knee swelling and knee range of motion, and complications."1.46Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty. ( Hansen, TB; Munk, S; Rytter, S; Stilling, M, 2017)
"Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain."1.39Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats. ( Araújo, CV; Barbosa, AL; Brito, GA; Câmara, CC; Costa, CM; da Silva, AP; Gomes, AS; Oriá, RB; Ramos, HF; Ribeiro, RA; Vale, ML, 2013)
"Both indomethacin and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR model."1.35Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009)
"Gabapentin was effective in the last two attacks."1.33A case of recurrent and migratory complex regional pain syndrome type I: Prevention by gabapentin. ( Akkus, S; Yener, M; Yorgancigil, H, 2006)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (35.71)29.6817
2010's5 (35.71)24.3611
2020's4 (28.57)2.80

Authors

AuthorsStudies
Largeau, B1
Bordy, R1
Pasqualin, C1
Bredeloux, P1
Cracowski, JL1
Lengellé, C1
Gras-Champel, V1
Auffret, M1
Maupoil, V1
Jonville-Béra, AP1
Khan, FA1
Ali, G1
Rahman, K1
Khan, Y1
Ayaz, M1
Mosa, OF1
Nawaz, A1
Hassan, SSU1
Bungau, S1
Read, SH1
Giannakeas, V1
Pop, P1
Bronskill, SE1
Herrmann, N1
Chen, S1
Luke, MJ1
Wu, W1
McCarthy, LM1
Austin, PC1
Normand, SL1
Gurwitz, JH1
Stall, NM1
Savage, RD1
Rochon, P1
Ahmad, N1
Subhan, F1
Islam, NU1
Shahid, M1
Ullah, N1
Ullah, R1
Khurram, M1
Amin, MU1
Akbar, S1
Ullah, I1
Sewell, RDE1
Câmara, CC1
Ramos, HF1
da Silva, AP1
Araújo, CV1
Gomes, AS1
Vale, ML1
Barbosa, AL2
Ribeiro, RA1
Brito, GA1
Costa, CM1
Oriá, RB1
Dias, JM1
de Brito, TV1
de Aguiar Magalhães, D1
da Silva Santos, PW1
Batista, JA1
do Nascimento Dias, EG1
de Barros Fernandes, H1
Damasceno, SR1
Silva, RO1
Aragão, KS1
Souza, MH1
Medeiros, JV1
Rytter, S1
Stilling, M1
Munk, S1
Hansen, TB1
Piesla, MJ1
Leventhal, L1
Strassle, BW1
Harrison, JE1
Cummons, TA1
Lu, P1
Whiteside, GT1
Hey, M1
Wilson, I1
Johnson, MI1
Erdoğan, G1
Ceyhan, D1
Güleç, S1
Guéguen, A1
Guy, C1
Cartry, O1
Bouchou, K1
Gouilloud, S1
Cathébras, P1
Kassuya, CA1
Silvestre, AA1
Rehder, VL1
Calixto, JB1
Parsons, B1
Tive, L1
Huang, S1
Akkus, S1
Yorgancigil, H1
Yener, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Preoperative Steroids Injection on Pain and Oedema After Total Knee Arthroplasty . A Double -Blinded Randomized Controlled Study.[NCT04084912]Phase 386 participants (Anticipated)Interventional2020-01-01Not yet recruiting
Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand[NCT05003596]Phase 2/Phase 360 participants (Anticipated)Interventional2021-09-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for gabapentin and Edema

ArticleYear
Gabapentin: a pooled analysis of adverse events from three clinical trials in patients with postherpetic neuralgia.
    The American journal of geriatric pharmacotherapy, 2004, Volume: 2, Issue:3

    Topics: Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Dizziness; Dose-Response Relationship, Drug;

2004

Other Studies

13 other studies available for gabapentin and Edema

ArticleYear
Gabapentinoid-induced peripheral edema and acute heart failure: A translational study combining pharmacovigilance data and in vitro animal experiments.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 149

    Topics: Aged; Aged, 80 and over; Animal Experimentation; Animals; Edema; Female; Gabapentin; Heart Failure;

2022
Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms.
    Molecules (Basel, Switzerland), 2022, Aug-25, Volume: 27, Issue:17

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cisplatin; Disease Models, Animal; Edema; Flavanones;

2022
Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain.
    Journal of the American Geriatrics Society, 2021, Volume: 69, Issue:10

    Topics: Aged; Aged, 80 and over; Cohort Studies; Diuretics; Edema; Female; Gabapentin; Humans; Inappropriate

2021
Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:10

    Topics: Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Carrageenan; Disease Models,

2021
Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats.
    Neuroscience letters, 2013, Nov-27, Volume: 556

    Topics: Administration, Oral; Amines; Analgesics; Animals; Cell Movement; Constriction, Pathologic; Cyclohex

2013
Gabapentin, a synthetic analogue of gamma aminobutyric acid, reverses systemic acute inflammation and oxidative stress in mice.
    Inflammation, 2014, Volume: 37, Issue:5

    Topics: Acute Disease; Amines; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Edema; Gabape

2014
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
    Brain research, 2009, Oct-27, Volume: 1295

    Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan;

2009
Stellate ganglion blockade (SGB) for refractory index finger pain - a case report.
    Annals of physical and rehabilitation medicine, 2011, Volume: 54, Issue:3

    Topics: Abdominal Pain; Accidental Falls; Acetaminophen; Adult; Amines; Autonomic Nerve Block; Chronic Disea

2011
Possible heart failure associated with pregabalin use: case report.
    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2011, Volume: 23, Issue:2

    Topics: Amines; Analgesics; Back Pain; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Edema; Female;

2011
[Edematous syndrome and alithiasic cholecystitis induced by gabapentin].
    Presse medicale (Paris, France : 1983), 2002, Oct-12, Volume: 31, Issue:33

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cholecystitis; Cyclohexanecarboxylic Acids; Edema; Epileps

2002
Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain.
    European journal of pharmacology, 2003, Oct-08, Volume: 478, Issue:2-3

    Topics: Acetates; Amines; Analgesics; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Edema;

2003
A case of recurrent and migratory complex regional pain syndrome type I: Prevention by gabapentin.
    Rheumatology international, 2006, Volume: 26, Issue:9

    Topics: Amines; Cyclohexanecarboxylic Acids; Edema; Foot Diseases; Gabapentin; gamma-Aminobutyric Acid; Huma

2006