Page last updated: 2024-10-27
gabapentin and Edema
gabapentin has been researched along with Edema in 14 studies
Gabapentin: A cyclohexane-gamma-aminobutyric acid derivative that is used for the treatment of PARTIAL SEIZURES; NEURALGIA; and RESTLESS LEGS SYNDROME.
gabapentin : A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this pooled analysis of adverse-event data from 3 clinical trials in patients with PHN, the incidence of peripheral edema was increased when gabapentin was titrated to >or=1800 mg/d." | 8.82 | Gabapentin: a pooled analysis of adverse events from three clinical trials in patients with postherpetic neuralgia. ( Huang, S; Parsons, B; Tive, L, 2004) |
| "Gabapentinoids are ligands of the α2-δ subunit of voltage-gated calcium channels (Cav) that have been associated with a risk of peripheral edema and acute heart failure in connection with a potentially dual mechanism, vascular and cardiac." | 8.12 | Gabapentinoid-induced peripheral edema and acute heart failure: A translational study combining pharmacovigilance data and in vitro animal experiments. ( Auffret, M; Bordy, R; Bredeloux, P; Cracowski, JL; Gras-Champel, V; Jonville-Béra, AP; Largeau, B; Lengellé, C; Maupoil, V; Pasqualin, C, 2022) |
| " The current study evaluated the pharmacological activity of gabapentin (GBP) and its salicylaldehyde derivative (gabapentsal; [2-(1-(((2-hydroxybenzylidene) amino) methyl) cyclohexyl) acetic acid]; GPS) in well-established mouse models of nociceptive pain, inflammatory edema, and pyrexia at doses of 25-100 mg/kg." | 8.02 | Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021) |
| " When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%)." | 7.72 | Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003) |
| "In this pooled analysis of adverse-event data from 3 clinical trials in patients with PHN, the incidence of peripheral edema was increased when gabapentin was titrated to >or=1800 mg/d." | 4.82 | Gabapentin: a pooled analysis of adverse events from three clinical trials in patients with postherpetic neuralgia. ( Huang, S; Parsons, B; Tive, L, 2004) |
| "Gabapentinoids are ligands of the α2-δ subunit of voltage-gated calcium channels (Cav) that have been associated with a risk of peripheral edema and acute heart failure in connection with a potentially dual mechanism, vascular and cardiac." | 4.12 | Gabapentinoid-induced peripheral edema and acute heart failure: A translational study combining pharmacovigilance data and in vitro animal experiments. ( Auffret, M; Bordy, R; Bredeloux, P; Cracowski, JL; Gras-Champel, V; Jonville-Béra, AP; Largeau, B; Lengellé, C; Maupoil, V; Pasqualin, C, 2022) |
| " The current study evaluated the pharmacological activity of gabapentin (GBP) and its salicylaldehyde derivative (gabapentsal; [2-(1-(((2-hydroxybenzylidene) amino) methyl) cyclohexyl) acetic acid]; GPS) in well-established mouse models of nociceptive pain, inflammatory edema, and pyrexia at doses of 25-100 mg/kg." | 4.02 | Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia. ( Ahmad, N; Akbar, S; Amin, MU; Islam, NU; Khurram, M; Sewell, RDE; Shahid, M; Subhan, F; Ullah, I; Ullah, N; Ullah, R, 2021) |
| " When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%)." | 3.72 | Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003) |
| "Outcome measures were postsurgical pain at rest and during walking, consumption of opioids for pain rescue, knee swelling and knee range of motion, and complications." | 1.46 | Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty. ( Hansen, TB; Munk, S; Rytter, S; Stilling, M, 2017) |
| "Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain." | 1.39 | Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats. ( Araújo, CV; Barbosa, AL; Brito, GA; Câmara, CC; Costa, CM; da Silva, AP; Gomes, AS; Oriá, RB; Ramos, HF; Ribeiro, RA; Vale, ML, 2013) |
| "Both indomethacin and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR model." | 1.35 | Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009) |
| "Gabapentin was effective in the last two attacks." | 1.33 | A case of recurrent and migratory complex regional pain syndrome type I: Prevention by gabapentin. ( Akkus, S; Yener, M; Yorgancigil, H, 2006) |
Research
Studies (14)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 4 (28.57) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Largeau, B | 1 |
| Bordy, R | 1 |
| Pasqualin, C | 1 |
| Bredeloux, P | 1 |
| Cracowski, JL | 1 |
| Lengellé, C | 1 |
| Gras-Champel, V | 1 |
| Auffret, M | 1 |
| Maupoil, V | 1 |
| Jonville-Béra, AP | 1 |
| Khan, FA | 1 |
| Ali, G | 1 |
| Rahman, K | 1 |
| Khan, Y | 1 |
| Ayaz, M | 1 |
| Mosa, OF | 1 |
| Nawaz, A | 1 |
| Hassan, SSU | 1 |
| Bungau, S | 1 |
| Read, SH | 1 |
| Giannakeas, V | 1 |
| Pop, P | 1 |
| Bronskill, SE | 1 |
| Herrmann, N | 1 |
| Chen, S | 1 |
| Luke, MJ | 1 |
| Wu, W | 1 |
| McCarthy, LM | 1 |
| Austin, PC | 1 |
| Normand, SL | 1 |
| Gurwitz, JH | 1 |
| Stall, NM | 1 |
| Savage, RD | 1 |
| Rochon, P | 1 |
| Ahmad, N | 1 |
| Subhan, F | 1 |
| Islam, NU | 1 |
| Shahid, M | 1 |
| Ullah, N | 1 |
| Ullah, R | 1 |
| Khurram, M | 1 |
| Amin, MU | 1 |
| Akbar, S | 1 |
| Ullah, I | 1 |
| Sewell, RDE | 1 |
| Câmara, CC | 1 |
| Ramos, HF | 1 |
| da Silva, AP | 1 |
| Araújo, CV | 1 |
| Gomes, AS | 1 |
| Vale, ML | 1 |
| Barbosa, AL | 2 |
| Ribeiro, RA | 1 |
| Brito, GA | 1 |
| Costa, CM | 1 |
| Oriá, RB | 1 |
| Dias, JM | 1 |
| de Brito, TV | 1 |
| de Aguiar Magalhães, D | 1 |
| da Silva Santos, PW | 1 |
| Batista, JA | 1 |
| do Nascimento Dias, EG | 1 |
| de Barros Fernandes, H | 1 |
| Damasceno, SR | 1 |
| Silva, RO | 1 |
| Aragão, KS | 1 |
| Souza, MH | 1 |
| Medeiros, JV | 1 |
| Rytter, S | 1 |
| Stilling, M | 1 |
| Munk, S | 1 |
| Hansen, TB | 1 |
| Piesla, MJ | 1 |
| Leventhal, L | 1 |
| Strassle, BW | 1 |
| Harrison, JE | 1 |
| Cummons, TA | 1 |
| Lu, P | 1 |
| Whiteside, GT | 1 |
| Hey, M | 1 |
| Wilson, I | 1 |
| Johnson, MI | 1 |
| Erdoğan, G | 1 |
| Ceyhan, D | 1 |
| Güleç, S | 1 |
| Guéguen, A | 1 |
| Guy, C | 1 |
| Cartry, O | 1 |
| Bouchou, K | 1 |
| Gouilloud, S | 1 |
| Cathébras, P | 1 |
| Kassuya, CA | 1 |
| Silvestre, AA | 1 |
| Rehder, VL | 1 |
| Calixto, JB | 1 |
| Parsons, B | 1 |
| Tive, L | 1 |
| Huang, S | 1 |
| Akkus, S | 1 |
| Yorgancigil, H | 1 |
| Yener, M | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Preoperative Steroids Injection on Pain and Oedema After Total Knee Arthroplasty . A Double -Blinded Randomized Controlled Study.[NCT04084912] | Phase 3 | 86 participants (Anticipated) | Interventional | 2020-01-01 | Not yet recruiting | ||
| Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand[NCT05003596] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
1 review available for gabapentin and Edema
| Article | Year |
|---|---|
Gabapentin: a pooled analysis of adverse events from three clinical trials in patients with postherpetic neuralgia.
Topics: Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Dizziness; Dose-Response Relationship, Drug; | 2004 |
Other Studies
13 other studies available for gabapentin and Edema
| Article | Year |
|---|---|
Gabapentinoid-induced peripheral edema and acute heart failure: A translational study combining pharmacovigilance data and in vitro animal experiments.
Topics: Aged; Aged, 80 and over; Animal Experimentation; Animals; Edema; Female; Gabapentin; Heart Failure; | 2022 |
Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cisplatin; Disease Models, Animal; Edema; Flavanones; | 2022 |
Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain.
Topics: Aged; Aged, 80 and over; Cohort Studies; Diuretics; Edema; Female; Gabapentin; Humans; Inappropriate | 2021 |
Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia.
Topics: Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Carrageenan; Disease Models, | 2021 |
Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats.
Topics: Administration, Oral; Amines; Analgesics; Animals; Cell Movement; Constriction, Pathologic; Cyclohex | 2013 |
Gabapentin, a synthetic analogue of gamma aminobutyric acid, reverses systemic acute inflammation and oxidative stress in mice.
Topics: Acute Disease; Amines; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Edema; Gabape | 2014 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; | 2009 |
Stellate ganglion blockade (SGB) for refractory index finger pain - a case report.
Topics: Abdominal Pain; Accidental Falls; Acetaminophen; Adult; Amines; Autonomic Nerve Block; Chronic Disea | 2011 |
Possible heart failure associated with pregabalin use: case report.
Topics: Amines; Analgesics; Back Pain; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Edema; Female; | 2011 |
[Edematous syndrome and alithiasic cholecystitis induced by gabapentin].
Topics: Acetates; Adult; Amines; Anticonvulsants; Cholecystitis; Cyclohexanecarboxylic Acids; Edema; Epileps | 2002 |
Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Edema; | 2003 |
A case of recurrent and migratory complex regional pain syndrome type I: Prevention by gabapentin.
Topics: Amines; Cyclohexanecarboxylic Acids; Edema; Foot Diseases; Gabapentin; gamma-Aminobutyric Acid; Huma | 2006 |