fumarates and Eczema

Hand eczema is a common distressing skin problem. It is an immune reaction to haptens. Thus, substances that inhibit Immune system can be effective in the treatment of hand eczema. In this study, topical fumaric acid 5% cream is compared with topical steroid in the treatment of hand eczema. Patients with hand eczema were randomly divided into two groups. One group received fumaric acid 5% in a cream base, and the other received triamcinolone 0.1% in the same cream base. Both groups used creams twice daily for one month. Patients were checked for erythema, excoriation, population and lichenification, EASI score, and pruritus before and after treatment. In both groups, the mean of all signs of the disease and EASI score decreased after one month of treatment. There was no significant difference between the two treatments in decreasing erythema, but excoriation, population, lichenification, EASI score and itching were all decreased more in triamcinolone 0.1 % group. Although fumaric acid can inhibit the immune system; it was less effective for the treatment of all signs of hand eczema except erythema in comparison to triamcinolone. These results may be justified for two reasons: low penetration of topical fumaric acid through the skin or a low concentration used in this study.

Topics: Administration, Topical; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Eczema; Female; Follow-Up Studies; Fumarates; Glucocorticoids; Hand; Humans; Male; Skin Cream; Skin Diseases; Treatment Outcome; Triamcinolone

Topics: Clinical Trials as Topic; Eczema; Fumarates; Histamine H1 Antagonists; Humans; Placebos; Pruritus; Pyrrolidines; Rhinitis, Allergic, Seasonal; Urticaria

There is now a well publicised increase in cases of sofa dermatitis since 2007. These have been linked to allergic contact sensitization to dimethlylfumarate, a novel contact allergen. We report on a case associated with a two year history of a treatment resistant dermatitis.

Topics: Adult; Dermatitis, Allergic Contact; Dimethyl Fumarate; Eczema; Environmental Illness; Female; Fumarates; Humans; Interior Design and Furnishings

Topics: Adult; Dimethyl Fumarate; Eczema; Female; Fumarates; Humans; Hypersensitivity; Petrolatum

We report on two cases of adverse reactions to topical treatment with monoethyl fumarate. One patient suffering from atopic dermatitis reacted with contact dermatitis; the other, suffering from psoriasis, developed a generalized, partly pustulous exanthema as well as signs of systemic involvement, such as tachycardia and dyspnea. As the causative mechanism we suggest non-immunological contact urticaria syndrome.

Topics: Administration, Topical; Adult; Anaphylaxis; Drug Eruptions; Eczema; Female; Fumarates; Humans; Male; Psoriasis