fr 74366 has been researched along with Cataract in 8 studies
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the effect of prefeeding the aldose reductase inhibitor (ARI) on the cataract induced by the subsequent feeding of galactose diet, rats were first fed rat chow with or without ARI for 2 weeks." | 7.68 | [Prefeeding of aldose reductase inhibitor inhibits galactose cataract]. ( Akagi, Y; Ikebe, H; Okamoto, S; Tanimoto, T; Terubayashi, H; Tsuji, T, 1993) |
| "This investigation compared the effects of two types of aldose reductase inhibitors on several biochemical parameters in naphthalene-induced cataract of the rat over a time span of 102 days of treatment." | 7.68 | Naphthalene-induced cataract in the rat. II. Contrasting effects of two aldose reductase inhibitors on glutathione and glutathione redox enzymes. ( Holleschau, AM; Rathbun, WB; Tao, RV, 1991) |
| "Preventional and reversal effects of a new aldose reductase inhibitor FR74366 on the rat galactose cataract were examined biochemically and light microscopically." | 7.68 | [Preventional and therapeutic effects of aldose reductase inhibitor FR74366 on rat galactose cataract]. ( Akagi, Y; Ikebe, H; Matsumoto, Y; Mori, K; Tanimoto, T; Terubayashi, H; Tsuji, T, 1990) |
| " One of these toxic findings was cataract, and we have found that cataract appeared in rats dosed orally with FK506 for 13 weeks and more." | 5.30 | Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. ( Fukuhara, Y; Hisatomi, A; Ishida, H; Mitamura, T; Murato, K; Ohara, K; Takahashi, Y, 1997) |
| "To examine the effect of prefeeding the aldose reductase inhibitor (ARI) on the cataract induced by the subsequent feeding of galactose diet, rats were first fed rat chow with or without ARI for 2 weeks." | 3.68 | [Prefeeding of aldose reductase inhibitor inhibits galactose cataract]. ( Akagi, Y; Ikebe, H; Okamoto, S; Tanimoto, T; Terubayashi, H; Tsuji, T, 1993) |
| "This investigation compared the effects of two types of aldose reductase inhibitors on several biochemical parameters in naphthalene-induced cataract of the rat over a time span of 102 days of treatment." | 3.68 | Naphthalene-induced cataract in the rat. II. Contrasting effects of two aldose reductase inhibitors on glutathione and glutathione redox enzymes. ( Holleschau, AM; Rathbun, WB; Tao, RV, 1991) |
| "Preventional and reversal effects of a new aldose reductase inhibitor FR74366 on the rat galactose cataract were examined biochemically and light microscopically." | 3.68 | [Preventional and therapeutic effects of aldose reductase inhibitor FR74366 on rat galactose cataract]. ( Akagi, Y; Ikebe, H; Matsumoto, Y; Mori, K; Tanimoto, T; Terubayashi, H; Tsuji, T, 1990) |
| "45 mug equiv/g, respectively, when dosed with [(14)C]lidorestat at 10 mg/kg po)." | 1.33 | Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. ( Dicioccio, AT; Geraci, LS; Gunn, DE; Jacot, JL; Jones, JH; Jones, ML; Mitschler, A; Petrova, T; Podjarny, AD; Sawicki, DR; Sredy, J; Van Zandt, MC, 2005) |
| " One of these toxic findings was cataract, and we have found that cataract appeared in rats dosed orally with FK506 for 13 weeks and more." | 1.30 | Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats. ( Fukuhara, Y; Hisatomi, A; Ishida, H; Mitamura, T; Murato, K; Ohara, K; Takahashi, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Zandt, MC | 1 |
| Jones, ML | 1 |
| Gunn, DE | 1 |
| Geraci, LS | 1 |
| Jones, JH | 1 |
| Sawicki, DR | 1 |
| Sredy, J | 1 |
| Jacot, JL | 1 |
| Dicioccio, AT | 1 |
| Petrova, T | 1 |
| Mitschler, A | 1 |
| Podjarny, AD | 1 |
| Tsuji, T | 2 |
| Okamoto, S | 2 |
| Ikebe, H | 3 |
| Terubayashi, H | 3 |
| Akagi, Y | 3 |
| Tanimoto, T | 2 |
| Ishida, H | 1 |
| Mitamura, T | 1 |
| Takahashi, Y | 1 |
| Hisatomi, A | 1 |
| Fukuhara, Y | 1 |
| Murato, K | 1 |
| Ohara, K | 1 |
| Tao, RV | 1 |
| Holleschau, AM | 1 |
| Rathbun, WB | 1 |
| Ao, S | 2 |
| Kikuchi, C | 2 |
| Ono, T | 1 |
| Notsu, Y | 2 |
| Shingu, Y | 1 |
| Takano, Y | 1 |
| Nomura, K | 1 |
| Fujiwara, T | 1 |
| Ohkubo, Y | 1 |
| Yamaguchi, I | 1 |
| Mori, K | 2 |
| Tsutsumi, M | 1 |
| Yoshizaki, K | 1 |
| Nishikawa, H | 1 |
| Matsumoto, Y | 1 |
8 other studies available for fr 74366 and Cataract
| Article | Year |
|---|---|
Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Topics: Aldehyde Reductase; Animals; Cataract; Chronic Disease; Crystallography, X-Ray; Diabetes Complicatio | 2005 |
[Prefeeding of aldose reductase inhibitor inhibits galactose cataract].
Topics: Aldehyde Reductase; Animals; Cataract; Crystallins; Galactitol; Galactose; Premedication; Quinazolin | 1993 |
Cataract development induced by repeated oral dosing with FK506 (tacrolimus) in adult rats.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Me | 1997 |
Naphthalene-induced cataract in the rat. II. Contrasting effects of two aldose reductase inhibitors on glutathione and glutathione redox enzymes.
Topics: Aldehyde Reductase; Animals; Body Weight; Cataract; Disease Models, Animal; Female; Fluorenes; Gluta | 1991 |
Effect of instillation of aldose reductase inhibitor FR74366 on diabetic cataract.
Topics: Administration, Topical; Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Len | 1991 |
Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetic Neuropathies; Diabetic Retinopathy; Female; Kinetics | 1991 |
[Quantitative study of rat diabetic cataract, by the relaxation times of nuclear magnetic resonance].
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Magnetic Resonance Spectrosc | 1991 |
[Preventional and therapeutic effects of aldose reductase inhibitor FR74366 on rat galactose cataract].
Topics: Aldehyde Reductase; Animals; Cataract; Galactose; Quinazolines; Rats; Sugar Alcohol Dehydrogenases | 1990 |