folic acid and Liver Neoplasms
folic acid has been researched along with Liver Neoplasms in 127 studies
Research
Studies (127)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (20.47) | 18.7374 |
| 1990's | 7 (5.51) | 18.2507 |
| 2000's | 11 (8.66) | 29.6817 |
| 2010's | 53 (41.73) | 24.3611 |
| 2020's | 30 (23.62) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hummel-Eisenbeiss, J; Jedlitschky, G; Keppler, D; Nies, AT; Rius, M | 1 |
| Abdalla, MS; Abdelhamed, RE; Abdelwahab, TS; Ali, EN; Mansour, NA | 1 |
| Gao, Y; Ge, S; Jiang, X; Liu, X; Liu, Y; Shen, W; Tian, Y; Wu, C; Wu, Q; Yu, Q | 1 |
| Elmasry, S; Elsayed, M; Ismail, SH; Moawad, M; Shosha, NNH | 1 |
| Bertino, G; Bonfiglio, C; Catania, VE; Drago, F; Madeddu, R; Malaguarnera, G; Malaguarnera, M | 1 |
| Aizenshtein, E; Besser, E; Feldman, A; Fokra, M; Hallo, E; Mukha, D; Nevo-Dinur, K; Sarvin, B; Sarvin, N; Schug, ZT; Shlomi, T | 1 |
| Hu, F; Li, Y; Ma, M; Meng, T; Shang, X; Shi, K; Tian, Y; Yuan, H | 1 |
| Fang, AP; He, TT; Liu, XZ; Liu, ZY; Luo, Y; Wusiman, M; Xiao, HW; Yishake, D; Zhu, HL | 1 |
| Ali, T; Kaur, J; Sharma, R | 2 |
| Ning, S; Wang, M; Xia, X; Xu, Y; Yang, Z; Zhou, L | 1 |
| Goyal, H; Kaur, J; Lamba, D; Sharma, R | 1 |
| Chen, X; Guo, B; Kalvakolanu, DV; Liu, X; Liu, Y; Sun, J; Wang, X; Xu, L; Zhang, L | 1 |
| Guo, J; Han, S; Li, Y; Li, YN; O'Driscoll, CM; Shi, X; Shi, Y; Sun, D; Wang, L; Yang, L; Zou, Y | 1 |
| Abe, K; Eguchi, S; Fukui, S; Inoue, Y; Ito, S; Kanetaka, K; Kobayashi, K; Kosaka, T; Kuba, S; Morita, M; Sakimura, C; Takatsuki, M; Yamanouchi, K | 1 |
| Gao, Y; Liu, T; Liu, X; Wu, C | 1 |
| Chen, S; Chen, X; Ding, L; Gao, Y; He, K; Jin, L; Jun, Y; Luo, C; Ma, J; Sun, S; Sun, X; Tang, Z; Tao, M; Wang, QL; Yao, M; Zhang, L; Zhang, M | 1 |
| Li, G; Li, X; Liu, C; Lu, T; Meng, F; Nong, Z; Qin, Q; Tang, B; Wei, L; Wei, M; Wu, N | 1 |
| Chen, Y; Li, W; Luo, L; Peng, Y; Wu, T; Xie, X; Yang, H | 1 |
| Antwi, SO; Campbell, PT; Liao, LM; McGlynn, KA; Norez, DA; Patel, T; Petrick, JL; Roberts, LR; Stevens, VL | 1 |
| He, DX; Huang, C; Huang, W; Liu, Y; Long, J; Tan, XW; Tang, S; Wei, H; Xiang, Y; Yu, CY; Zhou, Y | 1 |
| Guan, Q; Huang, L; Liu, Y; Wu, J; Zhang, G; Zhang, Z | 1 |
| Chen, L; Du, J; Gao, Y; Li, Q; Wang, J; Wang, S; Yang, Y; Yu, S | 1 |
| Feng, Y; Liu, M; Tu, J; Wu, J; Zhang, J | 1 |
| Buskaran, K; Fakurazi, S; Hussein, MZ; Mohd Moklas, MA | 1 |
| Bertino, G; Borzì, AM; Catania, VE; Drago, F; Latteri, S; Madeddu, R; Malaguarnera, G; Malaguarnera, M | 1 |
| Dong, Z; Fan, Z; Gao, P; Liu, Q; Lu, F | 1 |
| Li, D; Liu, S; Shen, L; Zhang, QY; Zhu, H; Zhu, J | 1 |
| Ali, T; Das, A; Duseja, A; Kaur, J; Negi, I; Sharma, R | 1 |
| Hejazi, SH; Maghsoudinia, F; Mehradnia, F; Mehrgardi, MA; Samani, RK; Sobhani, T; Tavakoli, MB | 1 |
| Gong, T; Guo, R; Huang, Y; Li, J; Li, M; Liang, W; Ma, Q; Su, D; Wang, X | 1 |
| Chan, CY; Chiu, DK; Lai, RK; Lan Li, L; Law, CT; Lee, D; Ng, IO; Tsang, FH; Tse, AP; Wei, LL; Wong, CC; Wong, CM; Xu, IM | 1 |
| Gamble, MV; Goyal, A; Gurvich, I; Manji, GA; Safyan, RA; Santella, RM; Shen, J; Siegel, AB; Strauss, JA; Wang, Q; Wu, HC; Yeh, CC | 1 |
| Chen, Z; Fan, F; Hu, C; Kong, D; Leng, X; Qin, Y; Sun, H; Wang, C; Wang, H; Wu, S; Zhang, L; Zhu, D | 1 |
| Chen, CF; Chern, CL; Ho, CT; Lai, KG; Liu, JJ; Liu, TZ | 1 |
| Carallo, S; Cascione, M; Di Corato, R; Dini, L; Fabregat, I; Hanafy, NAN; Leporatti, S; Malfettone, A; Nobile, C; Quarta, A; Rinaldi, R; Soukupova, J; Tasco, V | 1 |
| Chang, Z; Dong, WF; Li, M; Lu, M; Shao, D; Wang, Y; Wang, Z; Xu, Q; Yang, D; Yue, J | 1 |
| Chaurasiya, B; Du, Y; Huang, L; Sun, C; Tu, J; Wang, H; Webster, TJ; Wu, D | 1 |
| Anwar, DM; Bekhit, AA; Elkhodairy, KA; Elzoghby, AO; Helmy, MW; Kamal, MK; Khattab, SN | 1 |
| Fangchao, C; Haiyan, Z; Ruiyi, L; Xiulan, S; Zaijun, L | 1 |
| Cui, F; Kawashima, Y; Li, L; Liang, N; Sun, S; Wang, D; Yan, P | 1 |
| Chen, X; He, D; Qin, L; Wang, Y; Zhou, Y | 1 |
| Cao, P; Chen, Y; Cui, J; Li, Y; Li, Z; Liu, W; Shang, Y; Yin, X | 1 |
| Bai, A; Cao, Y; Hu, L; Liu, X; Liu, Y; Lv, H; Shang, W; Wu, C | 1 |
| Deng, Y; Feng, Z; Lian, B; Wu, M; Zhao, X; Zhong, C | 1 |
| Li, W; Wang, CJ; Wang, HZ | 1 |
| Chen, MS; Chen, PY; Fang, AP; Liao, GC; Ling, WH; Liu, ZY; Long, JA; Luo, Y; Wang, XY; Xu, XJ; Xu, YJ; Zhang, DM; Zhang, YJ; Zhong, RH; Zhou, ZG; Zhu, HL | 1 |
| Dajani, O; Glimelius, B; Guren, TK; Hamfjord, J; Johansen, JS; Kure, EH; Lingjærde, OC; Pallisgaard, N; Pfeiffer, P; Sorbye, H; Spindler, KG; Tveit, KM | 1 |
| Chen, H; Li, W; Tao, R; Wang, C; Ye, J; Zhang, C; Zhou, H | 1 |
| Bertino, G; Borzì, AM; Catania, VE; Drago, F; La Greca, G; Latteri, S; Malaguarnera, G; Malaguarnera, M | 1 |
| Kumar, J; Ramasamy, S; Reddy, GP; Venkatasubbu, GD | 1 |
| Cho, CS; Cho, MH; Jiang, HL; Kim, YK; Lee, JH; Minai-Tehrani, A | 1 |
| Gong, F; Ma, J; Shen, J; Zhang, F; Zhang, L; Zhang, P | 1 |
| Chen, YM; Chiang, EP; Lin, WL; Lin, YJ; Tang, FY; Wang, YC | 1 |
| Chen, J; Li, H; Li, X; Liang, B; Yi, W | 1 |
| Chen, CH; Cheng, CP; Huang, CY; Kuo, CS; Kuo, HT; Lu, CL; Syu Huang, RF; Yang, FL | 1 |
| Beland, FA; Campos, A; Carrilho, J; de Conti, A; Furtado, KS; Fuscoe, JC; Guariento, AH; Han, T; Moreno, FS; Pogribny, IP; Purgatto, E; Ross, SA; Shinohara, EM; Tryndyak, V | 1 |
| Fan, Y; Wu, Y; Zhang, L | 1 |
| Besznyák, I; Bursics, A; Dede, K; Fekete, A; Kőszegi, G; Láng, I; Mersich, T; Mester, G; Pörneczi, B | 1 |
| Bánfalvi, G; Bodnár, M; Borbély, J; Emri, M; Hajdu, I; Kollár, J; Márián, T; Sikula, J; Trencsényi, G; Vámosi, G | 1 |
| Kawano, Y; Taniai, N; Uchida, E; Ueda, J; Yoshida, H; Yoshioka, M | 1 |
| Azoulay, D; Calderaro, J; Zafrani, ES | 1 |
| Chen, GG; Ho, RL; Hu, BG; Lai, PB; Leung, KK; Lin, MC; Liu, LP; Ye, CG | 1 |
| Hackett, MJ; Hui, KM; Hyeon, T; Ling, D; Na, K; Park, W; Song, C; Xia, H | 1 |
| Dubrova, YE; Glen, CD; McVeigh, LE; Voutounou, M | 1 |
| Cai, L; Chang, SC; Ding, BG; Goldstein, BY; He, N; Heber, D; Lu, QY; Mu, L; You, NC; Yu, SZ; Zhang, ZF; Zhao, JK | 1 |
| He, N; Kang, Y; Li, M; Liu, B; Wu, H; Yuan, Y; Zeng, X; Zhang, G; Zhang, Y | 1 |
| Dong, M; Kong, FM; Li, YJ; Zhou, JP | 1 |
| Lei, QY; Li, JT; Ren, F; Wang, LY; Xu, YY; Yang, HB; Zhang, M; Zhang, Y; Zhao, XN; Zou, SW | 1 |
| He, J; Lai, C; Lu, X; Luo, G; Peng, Y; Xie, X; Xie, Y; Yu, X; Zhao, Y; Zhou, N; Zhou, S; Zhuo, H | 1 |
| Chen, L; Li, J; Pan, Y; Shao, D; Wang, Z; Zhang, H; Zhang, M; Zhang, X; Zheng, X | 1 |
| Chang, JB; Ho, CT; Liu, JJ; Liu, TZ; Shang, HS | 1 |
| Gao, Q; Hua, D; Huang, C; Wang, F; Yang, S; Yuan, J | 1 |
| Gao, B; He, KW; Shen, L; Xiao, WH | 1 |
| Arteta, B; Benedicto, A; Hernandez-Unzueta, I; Márquez, J; Mena, J; Olaso, E; Sanz, E | 1 |
| Cheng, SB; Huang, YC; Lai, CY; Lin, PT; Liu, HT | 1 |
| Chen, H; Gao, B; He, KW; Li, AH; Shen, L; Xiao, WH; Xu, J; Yang, HJ | 1 |
| Gao, JQ; Han, M; Hu, Y; Liu, L; Liu, MC; Shuai, WP; Wang, XR | 1 |
| Choi, JS; Cui, LH; Jiang, MH; Piao, JM; Quan, ZY; Shin, MH; Zhang, TT | 1 |
| Ge, S; Han, B; Hu, Y; Jiang, J; Li, K; Liu, Y; Wang, Y; Zhang, S | 1 |
| Li, C; Liang, ZQ; Liu, YX; Ni, J; Wang, H; Wang, X | 1 |
| Kuo, CS; Lin, CY; Lu, CL; Syu Huang, RF; Wu, MY | 1 |
| Choi, JS; Cui, LH; Kim, HN; Shen, F; Shin, MH; Si, H; Song, Y | 1 |
| Cheng, D; Hong, G; Niu, C; Sun, Q; Zhou, J | 1 |
| Freedman, ND; Graubard, BI; Hollenbeck, AR; McGlynn, KA; Park, Y; Persson, EC; Schwartz, LM; Trabert, B | 1 |
| French, AE; Grant, R; Greenberg, M; Koren, G; Ray, JG; Sung, L; Vermeulen, MJ; Weitzman, S | 1 |
| DAVIS, RE; JOSKE, RA; KELLY, A | 1 |
| Curley, SA; Ellis, LM; Gentner, B; Parikh, AA; Vauthey, JN; Wu, TT | 1 |
| Hattori, Y; Kawakami, H; Kawano, K; Maitani, Y; Ohguchi, Y; Shiokawa, T; Toma, K | 1 |
| Goldman, ID; Hanscom, M; Zhao, R | 1 |
| Chen, G; Evans, AA; Katki, HA; Lin, WY; London, WT; McGlynn, KA; O'Broin, S; Sakoda, LC; Shen, FM; Welzel, TM | 1 |
| Huang, RF; Kuo, CS; Lin, CY; Lu, CL; Wu, MY | 1 |
| Hong, G; Liang, B; Shen, J; Shuai, X; Yang, X; Yuan, R | 1 |
| Magnus, EM | 1 |
| Chiba, S; Kikuchi, S; Matsumoto, H; Wada, T | 1 |
| Mervis, J | 1 |
| Allegra, CJ | 1 |
| Abileah, S; Christman, JK; Dizik, M; Sheikhnejad, G; Wainfan, E | 1 |
| Henning, SM; Swendseid, ME | 1 |
| Lurain, JR | 1 |
| Beger, HG; Butzer, U; Danenberg, KD; Danenberg, PV; Kornmann, M; Leder, G; Link, KH; Pillasch, J; Salonga, D; Sunelaitis, E | 1 |
| Krupenko, SA; Oleinik, NV | 1 |
| Poirier, LA | 2 |
| Rogers, AE | 1 |
| Esther, G; Koch, K; Konrad, H; Kunkel, S; Maass, M; Nowotny, P; Rehpenning, W; Schwager, A | 1 |
| Archer, MC; Paglialunga, S; Tannenbaum, SR; Wogan, GN | 1 |
| Roth, JJ; Roth, JS | 1 |
| Areekul, S; Chantachum, Y; Hitanant, S; Panatampon, P | 1 |
| DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM | 1 |
| Bunni, M; Freisheim, JH; Galivan, J; Priest, DG; Rhee, M; Whiteley, JM | 1 |
| Balinska, M; Bunni, M; Galivan, J; Maley, F; Maley, GF; Priest, DG; Rhee, MS | 1 |
| Buamah, PK; Cornell, C; Harris, AL; James, OF; Skillen, AW | 1 |
| Newberne, PM; Rogers, AE | 1 |
| Buamah, PK; Harris, AL; James, OF; Skillen, AW | 1 |
| Bassendine, MF; Curtin, NJ; Harris, AL; James, OF; Loose, H | 1 |
| Duch, D; Ferone, R; Galivan, J; Gaumont, Y; Jones, C; Kisliuk, RL; Maley, F; Nair, MG; Patil, SD | 1 |
| Buamah, PK; Cassells-Smith, AJ; Harris, AL; James, OF; Skillen, AW | 1 |
| Bassendine, MF; Curtin, NJ; Harris, AL; James, OF | 1 |
| Bennett, M; Buamah, PK; James, OF; Lendrum, R; McArdle, P | 1 |
| Fox, H; Kondi, A; Linsell, CA; Parker, AM; Sizaret, P | 1 |
| Bukin, IuV; Raushenbakh, MO; Sergeev, AV | 1 |
| Maley, F; Maley, GF | 1 |
| Gottlieb, LS; Hegsted, DM; Iseri, OA; Vitale, JJ | 1 |
| Brown, GF; Schmid, FA; Schmid, MM; Sugiura, K | 1 |
| Ishihara, S | 2 |
Reviews
3 review(s) available for folic acid and Liver Neoplasms
| Article | Year |
|---|---|
The role of folate, choline, and methionine in carcinogenesis induced by methyl-deficient diets.
Topics: Animals; Choline; Choline Deficiency; Diet; Folic Acid; Folic Acid Deficiency; Humans; Liver Neoplasms; Methionine; Neoplasms | 1996 |
Management of high-risk gestational trophoblastic disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cyclophosphamide; Dactinomycin; Etoposide; Female; Folic Acid; Humans; Liver Neoplasms; Methotrexate; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms; Vincristine | 1998 |
Labile methyl groups and the promotion of cancer.
Topics: Animals; Antibody Formation; Carcinogens; Choline; Choline Deficiency; Diet; DNA; Folic Acid; Folic Acid Deficiency; Humans; Immunity, Cellular; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methylation; Neoplasms; Neoplasms, Experimental; Pharmaceutical Preparations; Risk; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 1986 |
Trials
2 trial(s) available for folic acid and Liver Neoplasms
| Article | Year |
|---|---|
Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cell-Free Nucleic Acids; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Female; Fluorouracil; Folic Acid; Follow-Up Studies; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Oxaliplatin; Prognosis; Prospective Studies; Retrospective Studies; Survival Rate | 2019 |
Thymidylate synthase quantitation and in vitro chemosensitivity testing predicts responses and survival of patients with isolated nonresectable liver tumors receiving hepatic arterial infusion chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Epirubicin; Female; Fluorouracil; Folic Acid; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Mitoxantrone; Predictive Value of Tests; Prospective Studies; Thymidylate Synthase; Treatment Outcome; Tumor Stem Cell Assay | 2000 |
Other Studies
122 other study(ies) available for folic acid and Liver Neoplasms
| Article | Year |
|---|---|
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Antibodies; Carcinoma, Hepatocellular; Cell Polarity; Cholagogues and Choleretics; Cricetinae; Fibroblasts; Gene Expression; Glutathione; Hepatocytes; Humans; Liver Neoplasms; Male; Mice; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Rats; Taurocholic Acid; Transfection; Transport Vesicles; Tritium | 2003 |
Evaluation of Silver Nanoparticles Caffeic Acid Complex Compound as New Potential Therapeutic Agent against Cancer Incidence in Mice.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Breast Neoplasms; Caffeic Acids; Carcinoma, Ehrlich Tumor; Caspase 3; Caspase 8; Female; Folic Acid; Glutathione; Glutathione Peroxidase; Hep G2 Cells; Humans; Liver Neoplasms; MCF-7 Cells; Metal Nanoparticles; Mice; Nanoconjugates; Neoplasms; Silver; Superoxide Dismutase; Tumor Necrosis Factors | 2021 |
Folate-functionalized SMMC-7721 liver cancer cell membrane-cloaked paclitaxel nanocrystals for targeted chemotherapy of hepatoma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomimetics; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Membrane; Cell Survival; Drug Carriers; Drug Liberation; Female; Folic Acid; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Paclitaxel; Particle Size; Polyethylene Glycols; Random Allocation; Surface Properties; Tumor Burden; Xenograft Model Antitumor Assays | 2022 |
Invivo and invitro evaluation of antitumor effects of iron oxide and folate core shell-iron oxide nanoparticles.
Topics: Animals; Ferric Compounds; Folic Acid; Liver Neoplasms; Magnetite Nanoparticles; Rats | 2022 |
Serum Folate deficiency in HCV related Hepatocellular Carcinoma.
Topics: Carcinoma, Hepatocellular; Folic Acid; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Homocysteine; Humans; Liver Cirrhosis; Liver Neoplasms; RNA | 2022 |
Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth.
Topics: Carcinoma, Hepatocellular; Folic Acid; Glycine; Glycine Dehydrogenase (Decarboxylating); Humans; Lipoylation; Liver Neoplasms; Mitochondrial Proteins; Nucleotides | 2022 |
A Hypoxia-Sensitive Drug Delivery System Constructed by Nitroimidazole and its Application in the Treatment of Hepatocellular Carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Folic Acid; Humans; Hypoxia; Liver Neoplasms; Micelles; Nitroimidazoles; Polyethylene Glycols; Tumor Microenvironment | 2022 |
Dietary intake of one-carbon metabolism-related nutrients and hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort.
Topics: Carbon; Carcinoma, Hepatocellular; Cohort Studies; Diet; Eating; Folic Acid; Humans; Liver Neoplasms; Methionine; Nutrients; Prospective Studies; Risk Factors | 2022 |
Folic acid depletion as well as oversupplementation helps in the progression of hepatocarcinogenesis in HepG2 cells.
Topics: Carcinogenesis; Carcinoma, Hepatocellular; Folic Acid; Hep G2 Cells; Humans; Liver Neoplasms; Necrosis; Sepharose | 2022 |
Development of Glycyrrhetinic Acid and Folate Modified Cantharidin Loaded Solid Lipid Nanoparticles for Targeting Hepatocellular Carcinoma.
Topics: Antineoplastic Agents; Cantharidin; Carcinoma, Hepatocellular; Drug Carriers; Emulsions; Folic Acid; Glycyrrhetinic Acid; Humans; Liver Neoplasms; Nanoparticles; Particle Size | 2022 |
Folic acid depletion along with inhibition of the PERK arm of endoplasmic reticulum stress pathway promotes a less aggressive phenotype of hepatocellular carcinoma cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; eIF-2 Kinase; Endoplasmic Reticulum Stress; Folic Acid; Humans; Liver Neoplasms; Phenotype; Unfolded Protein Response | 2023 |
Stat3 shRNA delivery with folate receptor-modified multi-functionalized graphene oxide particles for combined infrared radiation and gene therapy in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Folic Acid; Genetic Therapy; Liver Neoplasms; Mice; Polyethylene Glycols; Polyethyleneimine; RNA, Small Interfering; STAT3 Transcription Factor | 2023 |
Delivery of melarsoprol using folate-targeted PEGylated cyclodextrin-based nanoparticles for hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclodextrins; Folic Acid; Humans; Liver Neoplasms; Melarsoprol; Mice; Nanoparticles; Polyethylene Glycols | 2023 |
A Complete Response Achieved in a Patient with Hepatic Metastasis from Sigmoid Colon Cancer by a Regimen Containing Ramucirumab: a Case Report.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Folic Acid; Humans; Liver Neoplasms; Middle Aged; Oxaliplatin; Prognosis; Ramucirumab; Remission Induction; Sigmoid Neoplasms | 2020 |
Preparation of paclitaxel-folic acid functionalized gelatin grafted mesoporous hollow carbon nanospheres for enhancing antitumor effects toward liver cancer (SMMC-7721) cell lines.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon; Cell Line, Tumor; Cell Membrane Permeability; Drug Compounding; Drug Liberation; Folic Acid; Gelatin; Heterografts; Humans; Liver Neoplasms; Mice; Nanospheres; Neoplasms, Experimental; Paclitaxel; Porosity; Surface Properties | 2020 |
Nanovector Assembled from Natural Egg Yolk Lipids for Tumor-Targeted Delivery of Therapeutics.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Delivery Systems; Egg Yolk; Female; Folic Acid; Humans; Lipids; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Spectroscopy, Fourier Transform Infrared; Tissue Distribution; Xenograft Model Antitumor Assays | 2020 |
Preparation and anti-cancer activity of transferrin/folic acid double-targeted graphene oxide drug delivery system.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Delayed-Action Preparations; Doxorubicin; Drug Delivery Systems; Folic Acid; Graphite; Humans; Liver Neoplasms; Transferrin | 2020 |
Targeted delivery of Auristatin PE to Hep G2 cells using folate - conjugated boron nitride nanotubes.
Topics: Aminobenzoates; Apoptosis; Boron Compounds; Drug Delivery Systems; Folic Acid; Hep G2 Cells; Humans; Liver Neoplasms; Nanotubes; Oligopeptides | 2020 |
One-carbon metabolism-related micronutrients intake and risk for hepatocellular carcinoma: A prospective cohort study.
Topics: Carbon; Carcinoma, Hepatocellular; Diet; Dietary Supplements; Eating; Female; Folic Acid; Humans; Liver Neoplasms; Male; Methionine; Micronutrients; Middle Aged; Nutritional Status; Prospective Studies; Riboflavin; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2020 |
Facile Fabrication of Nanoparticles with Dual-Targeting Ligands for Precise Hepatocellular Carcinoma Therapy
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Chitosan; Fluorouracil; Folic Acid; Hepatocytes; Human Umbilical Vein Endothelial Cells; Humans; Ligands; Liver Neoplasms; Nanoparticles; Precision Medicine; Prodrugs; Solubility | 2020 |
Doxorubicin-loaded folate-mediated pH-responsive micelle based on Bletilla striata polysaccharide: Release mechanism, cellular uptake mechanism, distribution, pharmacokinetics, and antitumor effects.
Topics: Animals; Cell Movement; Cell Proliferation; Cell Survival; Doxorubicin; Female; Folic Acid; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Male; Mice; Micelles; Orchidaceae; Polysaccharides; Rats; Xenograft Model Antitumor Assays | 2020 |
Enhanced-fluorescent imaging and targeted therapy of liver cancer using highly luminescent carbon dots-conjugated foliate.
Topics: Carbon; Doxorubicin; Drug Delivery Systems; Folic Acid; Humans; Liver Neoplasms | 2020 |
Synergistic co-delivery of diacid metabolite of norcantharidin and ABT-737 based on folate-modified lipid bilayer-coated mesoporous silica nanoparticle against hepatic carcinoma.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Folic Acid; Lipid Bilayers; Liver; Liver Neoplasms; Mice; Nanoparticles; Nitrophenols; Piperazines; Silicon Dioxide; Sulfonamides | 2020 |
Morphological Changes and Cellular Uptake of Functionalized Graphene Oxide Loaded with Protocatechuic Acid and Folic Acid in Hepatocellular Carcinoma Cancer Cell.
Topics: Anticarcinogenic Agents; Biological Transport; Carcinoma, Hepatocellular; Drug Liberation; Folic Acid; Graphite; Hep G2 Cells; Humans; Hydroxybenzoates; Liver Neoplasms; Nanocomposites; Nanoparticles; Polyethylene Glycols; Vitamins | 2020 |
Tumor suppressor genes are differentially regulated with dietary folate modulations in a rat model of hepatocellular carcinoma.
Topics: Animal Feed; Animals; Apoptosis; Carcinoma, Hepatocellular; Core Binding Factor Alpha 3 Subunit; Diet; Disease Models, Animal; DNA Fragmentation; DNA Methylation; Folic Acid; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Liver Neoplasms; Male; Rats; Rats, Wistar; Suppressor of Cytokine Signaling 1 Protein; Tumor Suppressor Proteins | 2021 |
Folate levels in hepatocellular carcinoma patients with portal vein thrombosis.
Topics: Carcinoma, Hepatocellular; Female; Folic Acid; Humans; Liver Neoplasms; Male; Portal Vein; Retrospective Studies; Venous Thrombosis | 2020 |
Application of Abdominal Imaging Based on Nano Drug Delivery System for Diagnosis and Treatment of Liver Cancer.
Topics: Cell Survival; Doxorubicin; Drug Carriers; Drug Delivery Systems; Folic Acid; Humans; Liver Neoplasms; Nanoparticles; Silicon Dioxide | 2021 |
Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Benzophenanthridines; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Folic Acid; Humans; Liver Neoplasms; Micelles; Nanoparticles; Vitamin E | 2021 |
Dietary modulations of folic acid affect the development of diethylnitrosamine induced hepatocellular carcinoma in a rat model.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Folic Acid; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Rats; Rats, Wistar | 2021 |
Folic acid-functionalized gadolinium-loaded phase transition nanodroplets for dual-modal ultrasound/magnetic resonance imaging of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Contrast Media; Folic Acid; Gadolinium; Liver Neoplasms; Magnetic Resonance Imaging; Mice; Nanoparticles | 2021 |
Triformyl cholic acid and folic acid functionalized magnetic graphene oxide nanocomposites: Multiple-targeted dual-modal synergistic chemotherapy/photothermal therapy for liver cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cholic Acids; Combined Modality Therapy; Doxorubicin; Drug Carriers; Drug Liberation; Drug Therapy; Ferrosoferric Oxide; Folic Acid; Graphite; Humans; Infrared Rays; Liver Neoplasms; Magnetic Phenomena; Mice, Inbred BALB C; Nanocomposites; Photothermal Therapy | 2021 |
Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.
Topics: Aminohydrolases; Carcinoma, Hepatocellular; Folic Acid; Formate-Tetrahydrofolate Ligase; Hep G2 Cells; Humans; Liver Neoplasms; Methylenetetrahydrofolate Dehydrogenase (NADP); Multienzyme Complexes; Neoplasm Proteins; NF-E2-Related Factor 2 | 2017 |
Global Level of Plasma DNA Methylation is Associated with Overall Survival in Patients with Hepatocellular Carcinoma.
Topics: Biomarkers, Tumor; Carcinoma, Hepatocellular; DNA Methylation; Female; Folic Acid; Follow-Up Studies; Genome, Human; Humans; Liver Neoplasms; Long Interspersed Nucleotide Elements; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Prospective Studies; Survival Rate | 2017 |
Folate-targeted polymersomes loaded with both paclitaxel and doxorubicin for the combination chemotherapy of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Doxorubicin; Folic Acid; Humans; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Xenograft Model Antitumor Assays | 2017 |
Novel roles of folic acid as redox regulator: Modulation of reactive oxygen species sinker protein expression and maintenance of mitochondrial redox homeostasis on hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Folic Acid; Gene Expression Regulation, Neoplastic; Glutathione; Heat-Shock Proteins; Hep G2 Cells; Homeostasis; Humans; Inhibitor of Apoptosis Proteins; Isocitrate Dehydrogenase; Liver Neoplasms; Mice; Mitochondria; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Survivin | 2017 |
Hybrid polymeric-protein nano-carriers (HPPNC) for targeted delivery of TGFβ inhibitors to hepatocellular carcinoma cells.
Topics: Animals; Carcinoma, Hepatocellular; Cattle; Colloids; Drug Carriers; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Liver Neoplasms; Microscopy, Atomic Force; Microscopy, Fluorescence; Peptides; Polymers; RNA, Small Interfering; Serum Albumin, Bovine; Spectroscopy, Fourier Transform Infrared; Transforming Growth Factor beta | 2017 |
Janus Gold Nanoplatform for Synergetic Chemoradiotherapy and Computed Tomography Imaging of Hepatocellular Carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemoradiotherapy; Doxorubicin; Drug Screening Assays, Antitumor; Folic Acid; Gold; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Metal Nanoparticles; Mice; Neoplasms, Experimental; Particle Size; Porosity; Silicon Dioxide; Surface Properties; Tomography, X-Ray Computed | 2017 |
Versatile redox-sensitive pullulan nanoparticles for enhanced liver targeting and efficient cancer therapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Asialoglycoprotein Receptor; Drug Delivery Systems; Folate Receptor 1; Folic Acid; Glucans; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Paclitaxel; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2018 |
Lactobionic/Folate Dual-Targeted Amphiphilic Maltodextrin-Based Micelles for Targeted Codelivery of Sulfasalazine and Resveratrol to Hepatocellular Carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Disaccharides; Drug Delivery Systems; Folic Acid; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Micelles; Polysaccharides; Resveratrol; Sulfasalazine; Xenograft Model Antitumor Assays | 2018 |
Electrochemical sensor for detection of cancer cell based on folic acid and octadecylamine-functionalized graphene aerogel microspheres.
Topics: Amines; Biosensing Techniques; Blood Chemical Analysis; Electrochemical Techniques; Folic Acid; Graphite; Liver Neoplasms; Microspheres | 2018 |
Amphiphilic Polymeric Micelles Based on Deoxycholic Acid and Folic Acid Modified Chitosan for the Delivery of Paclitaxel.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chitosan; Deoxycholic Acid; Drug Carriers; Female; Folic Acid; Humans; Injections, Intravenous; Liver Neoplasms; MCF-7 Cells; Mice; Micelles; Neoplasm Transplantation; Paclitaxel; Particle Size; Xenograft Model Antitumor Assays | 2018 |
Surface-Modified Nanoerythrocyte Loading DOX for Targeted Liver Cancer Chemotherapy.
Topics: Administration, Intravenous; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Doxorubicin; Drug Compounding; Drug Delivery Systems; Drug Liberation; Drug Screening Assays, Antitumor; Erythrocytes; Folic Acid; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2018 |
Folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks: fluorescence and magnetic resonance dual-modality imaging and photodynamic therapy in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Death; Cell Survival; Embryo, Nonmammalian; Fluorescence; Folic Acid; Gadolinium; Hep G2 Cells; Humans; Liver Neoplasms; Magnetic Resonance Imaging; Metal-Organic Frameworks; Nanoparticles; Photochemotherapy; Time-Lapse Imaging; Zebrafish | 2019 |
Folate-Functionalized Mesoporous Hollow SnO
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Female; Folic Acid; Humans; Liver Neoplasms; Mice; Nanofibers; Nanoparticles; Paclitaxel; Tin Compounds | 2018 |
Folate-conjugated human serum albumin-encapsulated resveratrol nanoparticles: preparation, characterization, bioavailability and targeting of liver tumors.
Topics: Animals; Biological Availability; Biological Transport; Capsules; Cell Proliferation; Drug Carriers; Drug Repositioning; Folic Acid; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Nanoparticles; Rats; Resveratrol; Serum Albumin, Human | 2019 |
A novel conjunction of folate-targeted carbon nanotubes containing protohemin and oridonin-liposome loaded microbubbles for cancer chemo-sonodynamic therapy.
Topics: 3T3 Cells; Animals; Cell Line; Cell Line, Tumor; Diterpenes, Kaurane; Drug Carriers; Drug Delivery Systems; Folic Acid; Hemin; Hep G2 Cells; Humans; Liposomes; Liver Neoplasms; Mice; Microbubbles; Nanotubes, Carbon | 2019 |
Serum folate concentrations at diagnosis are associated with hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort study.
Topics: Adult; Aged; Biomarkers, Tumor; Carcinoma, Hepatocellular; China; Female; Folic Acid; Humans; Liver Neoplasms; Male; Middle Aged; Proportional Hazards Models; Prospective Studies | 2019 |
Characterization, Cytotoxicity and Genotoxicity of Graphene Oxide and Folate Coupled Chitosan Nanocomposites Loading Polyprenol and Fullerene Based Nanoemulsion Against MHCC97H Cells.
Topics: Carcinoma, Hepatocellular; Chitosan; Folic Acid; Fullerenes; Graphite; Humans; Liver Neoplasms; Nanocomposites; Oxides | 2019 |
Homocysteine Serum Levels as Prognostic Marker of Hepatocellular Carcinoma with Portal Vein Thrombosis.
Topics: Adult; Aged; Biomarkers, Tumor; Budd-Chiari Syndrome; Carcinoma, Hepatocellular; Cholesterol, LDL; Female; Folic Acid; Homocysteine; Humans; Liver Neoplasms; Male; Middle Aged; Portal Vein; Prognosis; Vitamin B 12; Vitamin B 6 | 2019 |
In vitro and in vivo anticancer activity of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Carriers; Durapatite; Folic Acid; Hematologic Tests; Hep G2 Cells; Humans; Liver Neoplasms; Male; Nanoparticles; Paclitaxel; Polyethylene Glycols; Rats; Rats, Wistar; Surface Properties; Titanium; Xenograft Model Antitumor Assays | 2013 |
Therapeutic efficiency of folated poly(ethylene glycol)-chitosan-graft-polyethylenimine-Pdcd4 complexes in H-ras12V mice with liver cancer.
Topics: Animals; Apoptosis Regulatory Proteins; Chitosan; DNA; Drug Carriers; Folic Acid; Genes, ras; Hep G2 Cells; Humans; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nanoparticles; Polyethylene Glycols; Polyethyleneimine; Random Allocation; RNA-Binding Proteins; Transfection; Xenograft Model Antitumor Assays | 2013 |
Targeted therapy for human hepatic carcinoma cells using folate-functionalized polymeric micelles loaded with superparamagnetic iron oxide and sorafenib in vitro.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Survival; Drug Carriers; Drug Delivery Systems; Ferrocyanides; Folic Acid; Hep G2 Cells; Humans; Liver Neoplasms; Magnetic Resonance Imaging; Magnetite Nanoparticles; Micelles; Microscopy, Electron, Transmission; Niacinamide; Phenylurea Compounds; Sorafenib | 2013 |
A novel role of the tumor suppressor GNMT in cellular defense against DNA damage.
Topics: Adenosine; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Dietary Supplements; DNA Damage; DNA Methylation; Female; Fluorescent Antibody Technique, Indirect; Folic Acid; Glycine N-Methyltransferase; Hepatocytes; Homocysteine; Humans; Liver; Liver Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Knockout; Minor Histocompatibility Antigens; Protein Transport; Purines; Pyrimidines; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydrofolates; Uracil | 2014 |
Acid-triggered core cross-linked nanomicelles for targeted drug delivery and magnetic resonance imaging in liver cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Drug Carriers; Folic Acid; Glutamic Acid; Humans; Liver Neoplasms; Magnetic Resonance Imaging; Magnetite Nanoparticles; Micelles; Particle Size; Polymers | 2013 |
Interrelationships among genetic C677T polymorphism of 5,10-methylenetetrahydrofolate reductase, biochemical folate status, and lymphocytic p53 oxidative damage in association with tumor malignancy and survivals of patients with hepatocellular carcinoma.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Carcinoma, Hepatocellular; Deoxyguanosine; DNA Damage; Erythrocytes; Female; Folic Acid; Gene Frequency; Genotype; Humans; Leukocytes, Mononuclear; Liver Neoplasms; Lymphocytes; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Oxidative Stress; Polymorphism, Genetic; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; Risk Factors; Tumor Suppressor Protein p53 | 2014 |
Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis.
Topics: Animals; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Folic Acid; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Humans; Liver Neoplasms; Male; Neoplasm Proteins; Neovascularization, Pathologic; Rats; Transcriptome; Triglycerides | 2014 |
Inositol based non-viral vectors for transgene expression in human cervical carcinoma and hepatoma cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Folic Acid; Genetic Vectors; HeLa Cells; Humans; Inositol; Liver Neoplasms; Magnetic Resonance Spectroscopy; Mice; Microscopy, Electron, Transmission; NIH 3T3 Cells; Spectroscopy, Fourier Transform Infrared | 2014 |
[Preoperative chemotherapy in the surgical treatment of colorectal liver metastases].
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Fluorouracil; Folic Acid; Hepatectomy; Hospitals, General; Humans; Irinotecan; Kaplan-Meier Estimate; Length of Stay; Liver Neoplasms; Male; Middle Aged; Neoadjuvant Therapy; Operative Time; Organoplatinum Compounds; Oxaliplatin; Surgery Department, Hospital; Treatment Outcome | 2013 |
Tumor-specific localization of self-assembled nanoparticle PET/MR modalities.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Chitosan; Contrast Media; Flow Cytometry; Folate Receptors, GPI-Anchored; Folic Acid; Liver Neoplasms; Magnetic Resonance Imaging; Male; Nanoparticles; Polyglutamic Acid; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 2014 |
Pulmonary edema caused by levofolinate treatment in patients with liver metastases from colorectal cancer.
Topics: Aged; Colorectal Neoplasms; Fatal Outcome; Folic Acid; Humans; Liver Neoplasms; Male; Pulmonary Edema; Radiography, Abdominal; Radiography, Thoracic; Tomography, X-Ray Computed | 2013 |
Hepatocellular carcinoma and nodular regenerative hyperplasia after chemotherapy for metastatic colorectal carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Colorectal Neoplasms; Drug Therapy; Fluorouracil; Folic Acid; Hepatectomy; Humans; Hyperplasia; Liver; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Vascular Diseases | 2014 |
Therapeutic efficacy of improved α-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma.
Topics: alpha-Fetoproteins; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Hepatocellular; Cellulose; Cyclodextrins; Folic Acid; Genetic Therapy; Genetic Vectors; Hep G2 Cells; Humans; Liver Neoplasms; Nanoparticles; Polyethyleneimine; Promoter Regions, Genetic; Treatment Outcome; Tumor Cells, Cultured | 2014 |
pH-sensitive nanoformulated triptolide as a targeted therapeutic strategy for hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemistry, Pharmaceutical; Diterpenes; Down-Regulation; Drug Liberation; Epoxy Compounds; Folic Acid; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Mice; Molecular Targeted Therapy; Nanostructures; Phenanthrenes; Survival Analysis; Xenograft Model Antitumor Assays | 2014 |
The effects of methyl-donor deficiency on the pattern of gene expression in mice.
Topics: Animals; Choline; Deficiency Diseases; Diet; Female; Folic Acid; Gene Expression Regulation; Kidney; Liver; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Inbred CBA; Spleen; Tissue Array Analysis | 2015 |
Plasma folate, vitamin B12, and homocysteine and cancers of the esophagus, stomach, and liver in a Chinese population.
Topics: Adult; Aged; Case-Control Studies; China; Esophageal Neoplasms; Female; Folic Acid; Homocysteine; Humans; Liver Neoplasms; Male; Middle Aged; Odds Ratio; Risk Factors; Stomach Neoplasms; Surveys and Questionnaires; Vitamin B 12 | 2015 |
The effects of multifunctional MiR-122-loaded graphene-gold composites on drug-resistant liver cancer.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Delivery Systems; Drug Resistance, Neoplasm; Female; Folic Acid; Gold; Graphite; Hep G2 Cells; Humans; Liver Neoplasms; Mice, Nude; MicroRNAs; Nanocomposites; Nanoparticles; Xenograft Model Antitumor Assays | 2015 |
Folate-decorated anticancer drug and magnetic nanoparticles encapsulated polymeric carrier for liver cancer therapeutics.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Folic Acid; Humans; Iron; Liver Neoplasms; Magnetic Phenomena; Nanoparticles; Niacinamide; Phenylurea Compounds; Polyesters; Polyethylene Glycols; Sorafenib | 2015 |
Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer.
Topics: Acetylation; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; E1A-Associated p300 Protein; Folic Acid; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hep G2 Cells; Histone Deacetylases; Humans; Liver Neoplasms; Male; Methionine Adenosyltransferase; Mice, Nude; Ubiquitination | 2015 |
Anti-tumor immune response of folate-conjugated chitosan nanoparticles containing the IP-10 gene in mice with hepatocellular carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Chemokine CXCL10; Chitosan; Cricetinae; DNA; Female; Folic Acid; Immunotherapy; Interferon gamma Receptor; Liver Neoplasms; Mice; Mice, Inbred BALB C; Nanocapsules; Particle Size; Receptors, Interferon; Transfection; Treatment Outcome | 2014 |
Noninvasive theranostic imaging of HSV-TK/GCV suicide gene therapy in liver cancer by folate-targeted quantum dot-based liposomes.
Topics: Animals; Antiviral Agents; Bile Ducts, Intrahepatic; Diagnostic Imaging; Folic Acid; Ganciclovir; Gene Transfer Techniques; Genes, Transgenic, Suicide; Genetic Therapy; Hep G2 Cells; Humans; Liposomes; Liver Neoplasms; Mice; Nanotechnology; Quantum Dots; Simplexvirus; Theranostic Nanomedicine; Thymidine Kinase | 2015 |
Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Survival; Culture Media; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endoplasmic Reticulum Chaperone BiP; Folic Acid; Heat-Shock Proteins; Hep G2 Cells; Humans; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Oxidation-Reduction; Reactive Oxygen Species; RNA Interference; Signal Transduction; Survivin | 2015 |
A novel preparation method of paclitaxcel-loaded folate-modified chitosan microparticles and in vitro evaluation.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Cell Line; Cell Survival; Chitosan; Drug Carriers; Drug Liberation; Fibroblasts; Folic Acid; Humans; Liver Neoplasms; Mice; Nanoparticles; Paclitaxel | 2016 |
GNRs@SiO₂-FA in combination with radiotherapy induces the apoptosis of HepG2 cells by modulating the expression of apoptosis-related proteins.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cytoplasm; Endocytosis; Folic Acid; Gold; Hep G2 Cells; Humans; Ki-67 Antigen; Liver Neoplasms; Nanotubes; Neoadjuvant Therapy; Proto-Oncogene Proteins c-bcl-2; Radiotherapy; Silicon Dioxide | 2015 |
Ocoxin® oral solution slows down tumor growth in an experimental model of colorectal cancer metastasis to the liver in Balb/c mice.
Topics: Animals; Apoptosis; Ascorbic Acid; Caspase 3; Cell Proliferation; Colorectal Neoplasms; Folic Acid; Gene Expression Regulation, Neoplastic; Glycyrrhizic Acid; Humans; Ki-67 Antigen; Liver Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Pantothenic Acid; Plant Extracts; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6; Zinc; Zinc Sulfate | 2016 |
Folate and vitamin B-6 status are not associated with homocysteine, oxidative stress and antioxidant capacities in patients with hepatocellular carcinoma.
Topics: Aged; Antioxidants; Carcinoma, Hepatocellular; Female; Folic Acid; Glutathione Peroxidase; Glutathione Transferase; Homocysteine; Humans; Liver Neoplasms; Male; Malondialdehyde; Middle Aged; Nutritional Status; Oxidative Stress; Pyridoxal Phosphate; Superoxide Dismutase; Vitamin B 6 | 2016 |
Cellular Uptake and Intra-Organ Biodistribution of Functionalized Silica-Coated Gold Nanorods.
Topics: Animals; Cell Survival; Disease Models, Animal; Endocytosis; Folic Acid; Gold; Hep G2 Cells; Humans; Liver Neoplasms; Luminescence; Male; Nanotubes; Photons; Rabbits; Silicon Dioxide; Spectrometry, X-Ray Emission; Tissue Distribution; Tomography, X-Ray Computed | 2016 |
Folate receptor-targeted liposomes loaded with a diacid metabolite of norcantharidin enhance antitumor potency for H22 hepatocellular carcinoma both in vitro and in vivo.
Topics: Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Proliferation; Chromatography, Liquid; Folate Receptor 1; Folic Acid; Half-Life; Humans; In Vitro Techniques; Liposomes; Liver Neoplasms; Male; Mice; Particle Size; Polyethylene Glycols; Tissue Distribution | 2016 |
Plasma Folate and Vitamin B12 Levels in Patients with Hepatocellular Carcinoma.
Topics: Adult; Aged; Biomarkers; Carcinoma, Hepatocellular; Case-Control Studies; Female; Folic Acid; Humans; Immunoassay; Liver Neoplasms; Luminescent Measurements; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Odds Ratio; Risk Factors; Vitamin B 12 | 2016 |
Preparation and Characterization of Novel Perfluorooctyl Bromide Nanoparticle as Ultrasound Contrast Agent via Layer-by-Layer Self-Assembly for Folate-Receptor-Mediated Tumor Imaging.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Contrast Media; Diagnostic Imaging; Drug Stability; Fluorocarbons; Folic Acid; Hemolysis; Humans; Hydrocarbons, Brominated; Liver Neoplasms; Materials Testing; Nanoparticles; Particle Size; Receptors, Cell Surface; Temperature; Ultrasonography | 2016 |
Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Progression; DNA Methylation; Folic Acid; Folic Acid Deficiency; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hepatocytes; Homeostasis; Humans; Liver Neoplasms; Methylenetetrahydrofolate Reductase (NADPH2); MicroRNAs; Poly A; RNA, Messenger | 2017 |
Lymphocytic mitochondrial DNA deletions, biochemical folate status and hepatocellular carcinoma susceptibility in a case-control study.
Topics: Aged; Alanine Transaminase; Alcohol Drinking; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Case-Control Studies; DNA Primers; DNA Probes; DNA, Mitochondrial; Female; Folic Acid; Gene Amplification; Genetic Predisposition to Disease; Humans; Liver Neoplasms; Lymphocytes; Magnetic Resonance Imaging; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Sequence Deletion; Smoking; Taiwan | 2009 |
Folate metabolism-related gene polymorphisms and susceptibility to primary liver cancer in North China.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Asian People; Case-Control Studies; China; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Liver Neoplasms; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Thymidylate Synthase | 2012 |
Folate-functionalized polymeric micelles based on biodegradable PEG-PDLLA as a hepatic carcinoma-targeting delivery system.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Delivery Systems; Folic Acid; Humans; Hydrogen-Ion Concentration; Ligands; Liver Neoplasms; Micelles; Polyesters; Polyethylene Glycols; Receptors, Cell Surface | 2011 |
Alcohol consumption, folate intake, hepatocellular carcinoma, and liver disease mortality.
Topics: Aged; Alcohol Drinking; Carcinoma, Hepatocellular; Diet; Female; Folic Acid; Follow-Up Studies; Humans; Incidence; Liver Diseases; Liver Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies; Risk Factors; United States | 2013 |
Folic acid food fortification is associated with a decline in neuroblastoma.
Topics: Canada; Child; Child, Preschool; Cross-Sectional Studies; Databases, Factual; Folic Acid; Food, Fortified; Hepatoblastoma; Humans; Liver Neoplasms; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2003 |
STUDIES ON THE STREPTOCOCCUS LACTIS FOLATE ACTIVITY OF HUMAN LIVER TISSUE.
Topics: Adolescent; Biopsy; Blood Chemical Analysis; Folic Acid; Geriatrics; Lactococcus lactis; Liver; Liver Diseases; Liver Neoplasms; Metabolism; Streptococcus; Vitamin B 12 | 1964 |
Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Camptothecin; Colonic Neoplasms; Female; Fluorouracil; Folic Acid; Hepatectomy; Humans; Irinotecan; Leucovorin; Liver Neoplasms; Male; Middle Aged; Neoadjuvant Therapy; Postoperative Complications; Retrospective Studies | 2003 |
Effect of polyethylene glycol linker chain length of folate-linked microemulsions loading aclacinomycin A on targeting ability and antitumor effect in vitro and in vivo.
Topics: Aclarubicin; Antibiotics, Antineoplastic; Carcinoma; Chemistry, Pharmaceutical; Emulsions; Folic Acid; Hepatoblastoma; Humans; Lipids; Liver Neoplasms; Nanostructures; Nasopharyngeal Neoplasms; Phosphatidylethanolamines; Polyethylene Glycols; Tumor Cells, Cultured | 2005 |
The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells.
Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Line, Tumor; Folic Acid; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Membrane Transport Proteins; Methotrexate; Reduced Folate Carrier Protein; RNA, Small Interfering; Transfection | 2005 |
Blood folate levels and risk of liver damage and hepatocellular carcinoma in a prospective high-risk cohort.
Topics: Alanine Transaminase; Carcinoma, Hepatocellular; China; Cohort Studies; DNA, Viral; Erythrocytes; Female; Folic Acid; Hepatitis B; Hepatitis B Surface Antigens; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Polymerase Chain Reaction; Prospective Studies | 2007 |
Relationship between folate status and tumour progression in patients with hepatocellular carcinoma.
Topics: Aged; alpha-Fetoproteins; Biomarkers, Tumor; Carcinoma, Hepatocellular; Chi-Square Distribution; Disease Progression; Female; Folic Acid; Folic Acid Deficiency; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Nutritional Status; Odds Ratio; Prospective Studies; Risk | 2008 |
Folate-functionalized polymeric micelle as hepatic carcinoma-targeted, MRI-ultrasensitive delivery system of antitumor drugs.
Topics: Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Contrast Media; Doxorubicin; Drug Carriers; Drug Delivery Systems; Ferric Compounds; Ferrocyanides; Folic Acid; Humans; Indicators and Reagents; Ligands; Liver Neoplasms; Micelles; Microscopy, Electron, Scanning; Models, Biological; Polyesters; Polyethylene Glycols; Polymers; Radiography; Sensitivity and Specificity; Tetrazolium Salts | 2008 |
Folate activity in serum and red cells of patients with cancer.
Topics: Adolescent; Adult; Aged; Bile Duct Neoplasms; Erythrocytes; Female; Folic Acid; Gallbladder Neoplasms; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Nutrition Disorders | 1967 |
[Various modes of folic acid deficiencies in neoplasms].
Topics: Animals; Folic Acid; Folic Acid Deficiency; Humans; Liver; Liver Neoplasms; Neoplasms; Neoplasms, Experimental; Rats | 1980 |
Epidemiology. China's unique environment favors large intervention trials.
Topics: China; Chronic Disease; Clinical Trials as Topic; Folic Acid; Hepatitis B; Hepatitis B Vaccines; Humans; Incidence; Liver Neoplasms; Neural Tube Defects; Randomized Controlled Trials as Topic; Stomach Neoplasms | 1995 |
New therapeutic strategies for patients with gastrointestinal malignancies using biochemical modulation of fluorouracil.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Colonic Neoplasms; Fatal Outcome; Fluorouracil; Folic Acid; Folic Acid Antagonists; Gastrointestinal Neoplasms; Gene Expression Regulation, Enzymologic; Humans; Interferon-alpha; Leucovorin; Liver Neoplasms; Male; Middle Aged; Prognosis; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thymidylate Synthase | 1995 |
Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency.
Topics: Amino Acid Sequence; Animals; Choline; DNA; Folic Acid; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, myc; Genes, ras; Liver; Liver Neoplasms; Male; Methionine; Methylation; Methyltransferases; Molecular Sequence Data; Rats; Rats, Inbred F344; RNA, Messenger; RNA, Transfer; Vitamin B 12 | 1993 |
10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells.
Topics: Adenocarcinoma; Cell Division; Cell Line, Transformed; Down-Regulation; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Liver Regeneration; Lung Neoplasms; Male; Oxidoreductases Acting on CH-NH Group Donors; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 2002 |
Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes.
Topics: Animals; Betaine; Carcinogens; Carcinoma, Hepatocellular; Choline; Diet; Ethanolamines; Folic Acid; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methotrexate; Neoplasms, Experimental; Nitrosamines; Organ Size; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Vitamin B 12 | 1975 |
Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet.
Topics: Amino Acids; Animals; Body Weight; Carcinoma, Hepatocellular; Choline; Diet; Dietary Fats; Diethylnitrosamine; Esophageal Neoplasms; Folic Acid; Hemangioendothelioma; Lipotropic Agents; Liver Neoplasms; Male; Methionine; Neoplasms, Experimental; Nicotinic Acids; Nitrosamines; Rats | 1977 |
[Complex genesis of anemia in chronic liver diseases].
Topics: Adult; Anemia; Chronic Disease; Erythrocyte Count; Erythrocyte Volume; Folic Acid; Hematocrit; Humans; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Neoplasm Metastasis; Vitamin B 12 | 1978 |
Carcinogenicity of nitrosation products of ephedrine, sarcosine, folic acid, and creatinine.
Topics: Adenoma, Bile Duct; Animals; Carcinogens; Carcinoma; Creatinine; Ephedrine; Folic Acid; Hyperplasia; Lethal Dose 50; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasms, Experimental; Neurofibroma; Nitro Compounds; Nitroso Compounds; Precancerous Conditions; Sarcosine | 1975 |
Thymidylate synthetase activity in the Novikoff hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Cycloheximide; Dactinomycin; Folic Acid; Liver Neoplasms; Male; Methotrexate; Methyltransferases; Neoplasms, Experimental; Puromycin; Rats; Tetrahydrofolates; Thymidylate Synthase | 1976 |
Serum vitamin B12 and folate levels, vitamin B12 and folic acid binding proteins in patients with primary carcinoma of the liver.
Topics: Adult; Aged; Carcinoma; Carrier Proteins; Folic Acid; Humans; Liver Neoplasms; Middle Aged; Vitamin B 12 | 1977 |
Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice.
Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Drug Evaluation, Preclinical; Female; Folic Acid; Leukemia L1210; Liver Neoplasms; Male; Methotrexate; Mice; Neoplasms, Experimental; Plasmacytoma; Sarcoma 180 | 1978 |
The effect of methotrexate on the folate coenzyme pools in human hepatoma cells in culture.
Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Deoxyuridine; Folic Acid; Glycine; Humans; Kinetics; Liver Neoplasms; Methotrexate; Tritium; Tumor Cells, Cultured | 1991 |
Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells.
Topics: Carcinoma, Hepatocellular; Folic Acid; Liver Neoplasms; Pteroylpolyglutamic Acids; Quinazolines; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Trimetrexate; Tumor Cells, Cultured | 1990 |
Serial serum AFP heterogeneity changes in patients with hepatocellular carcinoma during chemotherapy.
Topics: alpha-Fetoproteins; Carcinoma, Hepatocellular; Concanavalin A; Folic Acid; Humans; Liver Neoplasms; Quinazolines | 1986 |
Serum vitamin B12 levels in patients with primary hepatocellular carcinoma during treatment with CB3717.
Topics: Adult; Aged; alpha-Fetoproteins; Carcinoma, Hepatocellular; Female; Folic Acid; Follow-Up Studies; Humans; L-Lactate Dehydrogenase; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Quinazolines; Vitamin B 12 | 1987 |
Induction of remission in hepatocellular carcinoma with a new thymidylate synthase inhibitor, CB3717. A phase II study.
Topics: Adult; Aged; alpha-Fetoproteins; Carcinoma, Hepatocellular; Drug Evaluation; Female; Folic Acid; Follow-Up Studies; Humans; Liver Neoplasms; Male; Middle Aged; Quinazolines; Remission Induction | 1987 |
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.
Topics: Breast Neoplasms; Carcinoma, Hepatocellular; Chemical Phenomena; Chemistry; Fibroblasts; Folic Acid; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Liver Neoplasms; Lymphoma; Molecular Structure; Streptococcus; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured | 1989 |
Intestinal alkaline phosphatase isoenzyme in patients with primary liver cancer during treatment with N10-propargyl 5, 8-dideazafolic acid (CB 3717).
Topics: Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Female; Folic Acid; gamma-Glutamyltransferase; Humans; Intestinal Mucosa; Isoenzymes; Liver Neoplasms; Male; Middle Aged; Quinazolines; Time Factors | 1988 |
Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Humans; In Vitro Techniques; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thymidine | 1986 |
A pleomorphic hepatocellular carcinoma with biochemical features of fibrolamellar hepatocellular carcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Combined Modality Therapy; Doxorubicin; Etoposide; Female; Folic Acid; Humans; Liver Neoplasms; Neurotensin; Quinazolines; Vitamin B 12 | 1986 |
The alpha 1-fetoprotein test in hepatocellular carcinoma.
Topics: Animals; Diet; Fetal Proteins; Folic Acid; Haplorhini; Liver Neoplasms; Pyridoxine; Tryptophan; Vitamin B 12; Vitamin B 6 Deficiency | 1970 |
[New route of regulating folic acid metabolism in experimental chemotherapy of leukoses and malignant neoplasms].
Topics: Animals; Carcinoma, Hepatocellular; Cycloserine; Female; Folic Acid; Leukemia, Experimental; Liver; Liver Neoplasms; Lymphoma, Non-Hodgkin; Male; Methotrexate; Mice; Neoplasms, Experimental; Pyridoxal Phosphate; Rats; Spleen; Tetrahydrofolate Dehydrogenase; Transferases | 1971 |
The apparent induction of thymidylate synthetase by amethopterin.
Topics: Animals; Aspartic Acid; Benzoates; Carcinoma, Hepatocellular; Enzyme Induction; Folic Acid; Hepatectomy; Liver; Liver Neoplasms; Liver Regeneration; Methotrexate; Methyltransferases; Neoplasms, Experimental; Quinazolines; Rats; Thymine Nucleotides; Uracil Nucleotides | 1971 |
Vitamin B 12 and methionine metabolism in the Buffalo rat liver and Morris 5123 hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Choline Deficiency; Fatty Liver; Folic Acid; Homocystine; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Methionine; Methylation; Neoplasms, Experimental; Nutrition Disorders; Rats; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
Effect of compounds on a spectrum of rat tumors.
Topics: Adrenal Gland Neoplasms; Alkylating Agents; Amides; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Female; Fibrosarcoma; Folic Acid; Kidney Neoplasms; Liver Neoplasms; Lymphoma, Non-Hodgkin; Neoplasms, Experimental; Ovarian Neoplasms; Purines; Pyrimidines; Quinolines; Rats; Sarcoma; Sarcoma, Yoshida; Steroids | 1972 |
Folate deficiency in rats bearing the Walker tumor 256 and the Novikoff hepatoma.
Topics: Adenine; Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Choline; Diet; FIGLU Test; Folic Acid; Folic Acid Deficiency; Formates; Glycine; Guanine; Liver Neoplasms; Male; Methionine; Neoplasms, Experimental; Rats; Serine; Thymidine; Vitamin B 12 | 1973 |
Clinical and experimental evaluation of urinary histidine derivatives as an index of folic acid metabolism. II. The observation in neoplastic diseases with or without methotrexate administration.
Topics: Adult; Aged; Animals; Blood Cell Count; Blood Platelets; Dogs; Female; FIGLU Test; Folic Acid; Histidine; Humans; Leukocyte Count; Liver Neoplasms; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasms | 1969 |
Clinical and experimental evaluation of urinary histidine derivatives as an index of folic acid metabolism. 3. Clinical observation in liver disease.
Topics: Acute Disease; Chronic Disease; Coenzymes; Folic Acid; Hepatitis; Histidine; Humans; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Vitamin B 12 | 1970 |