fentanyl and Nausea
fentanyl has been researched along with Nausea in 129 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain." | 9.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| "The aims of this study were to explore the efficacy of intranasal fentanyl spray* (INFS) 400 μg to evaluate 12-week tolerability of the nasal mucosa and to explore safety data for all dose strengths of INFS in patients with cancer-related breakthrough pain (BTP)." | 9.20 | Efficacy and tolerability of intranasal fentanyl spray in cancer patients with breakthrough pain. ( Eeg, M; Jaatun, E; Kaasa, S; Kvitberg, M; Popper, L; Thronæs, M, 2015) |
| "In this study we evaluated the efficacy and tolerability of sublingual fentanyl (SLF) for breakthrough pain (BTP) in adult opioid-tolerant cancer patients." | 9.14 | Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study. ( Derrick, R; Frank-Lissbrant, I; Howell, J; Kälkner, KM; Lennernäs, B; Lennernäs, H, 2010) |
| "Omission of fentanyl did not reduce the overall incidence of postoperative nausea and vomiting, but did reduce the incidence of vomiting and/or moderate to severe nausea prior to discharge from 20% and 17% with fentanyl and fentanyl-dexamethasone, respectively, to 5% (P = 0." | 9.13 | Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery. ( Bridgman, S; Smith, I; Walley, G, 2008) |
| "We investigated the efficacy and safety of transdermal fentanyl for severe mucositis pain caused by chemotherapy." | 9.13 | Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy. ( Cai, Q; Guo, Y; Huang, H; Li, Y; Lin, X; Sun, X; Xia, Z, 2008) |
| "The use of OTFC can provide improved pain control when compared with IV morphine." | 9.12 | A randomized clinical trial of oral transmucosal fentanyl citrate versus intravenous morphine sulfate for initial control of pain in children with extremity injuries. ( Christopher, NC; Kennedy, CS; Mahar, PJ; Rana, JA, 2007) |
| " This difference was still significant when controlling for age, body weight, history of motion sickness, previous PONV episodes, duration of anesthesia, and intraoperative fentanyl consumption using a logistic model." | 9.08 | Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting. ( Finco, G; Gottin, L; Grosso, S; Ischia, S; Mosaner, W; Pinaroli, AM; Polati, E; Verlato, G, 1997) |
| "A prospective, comparative, randomized study to assess rectal acetaminophen (n = 45) to intravenous fentanyl-droperidol (n = 45) to resolve recovery profile, emesis rate, and adequacy of analgesia in a pediatric strabismus repair population was performed, with standardization of the anesthetic technique." | 9.08 | Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol. ( Cruz, OA; Krock, JL; Padda, GS, 1997) |
| "We compared the incidence of postoperative nausea and vomiting after total intravenous propofol-fentanyl anesthesia (TIVA group) and that after thiamylal-nitrous oxide-isoflurane anesthesia (GOI group) in 60 ASA physical I and II patients for elective abdominal simple total hysterectomy." | 9.08 | [A comparison of the incidence of postoperative nausea and vomiting after propofol-fentanyl anesthesia and that after nitrous oxide-isoflurane anesthesia]. ( Asada, A; Koh, H; Koyama, S; Noda, K; Tagami, N, 1998) |
| "At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy." | 9.07 | Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993) |
| "All communications on the use of transdermal fentanyl as well as the recommendations of the manufacturer include the direction that patients should be titrated with a short-acting narcotic to control their cancer pain before they are converted to a fentanyl transdermal therapeutic system (TTS)." | 9.07 | Transdermal fentanyl in uncontrolled cancer pain: titration on a day-to-day basis as a procedure for safe and effective dose finding--a pilot study in 20 patients. ( Korte, W; Morant, R, 1994) |
| "The findings indicate comparability of transdermal buprenorphine and transdermal fentanyl for pain measures with significantly fewer adverse events (nausea and treatment discontinuation due to adverse events) caused by transdermal buprenorphine." | 8.88 | Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain. ( Aune, D; Hernandez, AV; Kleijnen, J; Misso, K; Riemsma, R; Truyers, C; Wolff, RF, 2012) |
| "Transdermal fentanyl is a useful opioid-agonist for the treatment of moderate to severe chronic cancer pain." | 8.81 | Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control. ( Muijsers, RB; Wagstaff, AJ, 2001) |
| "The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement." | 7.74 | [Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine]. ( Abe, F; Furuya, A; Nagamine, N; Nonaka, A; Suzuki, S, 2007) |
| "The fentanyl transdermal matrix patch is approved in Japan for the management of moderate to severe cancer-related pain in adults." | 7.74 | Fentanyl transdermal matrix patch (Durotep MT patch; Durogesic DTrans; Durogesic SMAT): in adults with cancer-related pain. ( Hoy, SM; Keating, GM, 2008) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 7.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| "One-hundred and eighty patients undergoing elective abdominal hysterectomy were anaesthetized in random order with isoflurane, enflurane or fentanyl in combination with nitrous oxide and oxygen." | 6.66 | Nausea and vomiting after general anaesthesia with isoflurane, enflurane or fentanyl in combination with nitrous oxide and oxygen. ( Erkola, O; Hovorka, J; Korttila, K, 1988) |
| "The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain." | 5.69 | Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023) |
| " After thyroidectomy, we evaluated postoperative pain, nausea, fentanyl consumption, frequency of pushing the button (FPB) for patient-controlled analgesia (PCA), High-sensitivity C-reactive protein (hs-CRP) in serum, and patient satisfaction scores regarding the recovery process." | 5.22 | Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. ( Ahn, EJ; Baek, CW; Choi, GJ; Jung, YH; Kang, H; Kim, JY; Oh, JI, 2016) |
| "The aims of this study were to explore the efficacy of intranasal fentanyl spray* (INFS) 400 μg to evaluate 12-week tolerability of the nasal mucosa and to explore safety data for all dose strengths of INFS in patients with cancer-related breakthrough pain (BTP)." | 5.20 | Efficacy and tolerability of intranasal fentanyl spray in cancer patients with breakthrough pain. ( Eeg, M; Jaatun, E; Kaasa, S; Kvitberg, M; Popper, L; Thronæs, M, 2015) |
| " Nausea was significantly more common in the fentanyl group compared with both other groups." | 5.19 | The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study. ( Choi, DK; Choi, IC; Kim, K; Kim, WJ; Lee, YK; Sim, JY, 2014) |
| "The purpose of this trial was to evaluate the effect of long-term treatment with oral sustained-release hydromorphone, transdermal fentanyl, and transdermal buprenorphine on nausea, emesis and constipation." | 5.14 | Gastrointestinal symptoms under opioid therapy: a prospective comparison of oral sustained-release hydromorphone, transdermal fentanyl, and transdermal buprenorphine. ( Kloecker, N; Mueller, M; Nadstawek, J; Schaefer, N; Schenk, M; Schroeck, A; Standop, J; Wirz, S; Wittmann, M, 2009) |
| "In this study we evaluated the efficacy and tolerability of sublingual fentanyl (SLF) for breakthrough pain (BTP) in adult opioid-tolerant cancer patients." | 5.14 | Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study. ( Derrick, R; Frank-Lissbrant, I; Howell, J; Kälkner, KM; Lennernäs, B; Lennernäs, H, 2010) |
| "We investigated the efficacy and safety of transdermal fentanyl for severe mucositis pain caused by chemotherapy." | 5.13 | Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy. ( Cai, Q; Guo, Y; Huang, H; Li, Y; Lin, X; Sun, X; Xia, Z, 2008) |
| "Omission of fentanyl did not reduce the overall incidence of postoperative nausea and vomiting, but did reduce the incidence of vomiting and/or moderate to severe nausea prior to discharge from 20% and 17% with fentanyl and fentanyl-dexamethasone, respectively, to 5% (P = 0." | 5.13 | Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery. ( Bridgman, S; Smith, I; Walley, G, 2008) |
| "At all recorded intervals, the average degree of nausea was greater in the sodium citrate group compared to the famotidine group." | 5.12 | Oral sodium citrate increases nausea amongst elective Cesarean delivery patients. ( Abramovitz, S; Comerford, M; DiMaria, L; Gadalla, F; Kiselev, M; Kjaer, K; Kondilis, L; Leighton, BL; Samuels, J, 2006) |
| "The addition of small dose of morphine to the spinal component of the CSE technique improved the effectiveness of epidural labour analgesia and reduced the need for pain medications over 24 h, but resulted in a small increase in nausea." | 5.12 | Intrathecal morphine reduces breakthrough pain during labour epidural analgesia. ( Hess, PE; Sarge, TW; Snowman, CE; Sundar, S; Vasudevan, A, 2007) |
| "The use of OTFC can provide improved pain control when compared with IV morphine." | 5.12 | A randomized clinical trial of oral transmucosal fentanyl citrate versus intravenous morphine sulfate for initial control of pain in children with extremity injuries. ( Christopher, NC; Kennedy, CS; Mahar, PJ; Rana, JA, 2007) |
| "PCIA with sufentanil provides better efficacy of analgesia and sedation with lower incidence of nausea and vomiting than with fentanyl in postoperative patients with thoracotomy." | 5.12 | [Patient-controlled intravenous analgesia with sufentanil and fentanyl after thoracotomy: a comparative study]. ( Gu, MN; Lin, CS; Lu, G; Ruan, LY, 2006) |
| "5 mg bupivacaine given intrathecally via combined spinal epidural (CSE) for labour pain relief in the first stage." | 5.09 | Combined spinal epidural for labour analgesia--duration, efficacy and side effects of adding sufentanil or fentanyl to bupivacaine intrathecally vs plain bupivacaine. ( Chen, LH; Chong, JL; Lo, WK, 1999) |
| " We recorded pain as assessed on a visual analog scale, extension of sensory and motor block, maternal hemodynamic constants, number of boluses of bupivacaine used, total doses of bupivacaine and oxytocin, instruments needed for childbirth, and side effects (pruritus, nausea and vomiting)." | 5.09 | [The efficacy and safety of continuous epidural analgesia versus intradural-epidural analgesia during labor]. ( Caba, F; Calderón, J; Echevarría, M; Gómez, P; Martínez, A; Rodríguez, R, 2001) |
| "Propofol-fentanyl seems to be a better anesthetic than isoflurane-fentanyl in reducing the incidence of nausea and vomiting after middle ear surgery." | 5.08 | Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery. ( Fowles, S; Jellish, WS; Leonetti, JP; Murdoch, JR, 1995) |
| "Controversy exists regarding the effectiveness of propofol to prevent postoperative nausea and vomiting." | 5.08 | Antiemetic activity of propofol after sevoflurane and desflurane anesthesia for outpatient laparoscopic cholecystectomy. ( Song, D; White, PF; Whitten, CW; Yu, SY; Zarate, E, 1998) |
| "We compared the incidence of postoperative nausea and vomiting after total intravenous propofol-fentanyl anesthesia (TIVA group) and that after thiamylal-nitrous oxide-isoflurane anesthesia (GOI group) in 60 ASA physical I and II patients for elective abdominal simple total hysterectomy." | 5.08 | [A comparison of the incidence of postoperative nausea and vomiting after propofol-fentanyl anesthesia and that after nitrous oxide-isoflurane anesthesia]. ( Asada, A; Koh, H; Koyama, S; Noda, K; Tagami, N, 1998) |
| "05 mg kg(-1) +droperidol 20 microg kg(-1) was given as prophylaxis for postoperative pain and emesis, respectively." | 5.08 | Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy. ( Aasbø, V; Buanes, T; Grøgaard, B; Mjåland, O; Raeder, JC, 1998) |
| "A prospective, comparative, randomized study to assess rectal acetaminophen (n = 45) to intravenous fentanyl-droperidol (n = 45) to resolve recovery profile, emesis rate, and adequacy of analgesia in a pediatric strabismus repair population was performed, with standardization of the anesthetic technique." | 5.08 | Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol. ( Cruz, OA; Krock, JL; Padda, GS, 1997) |
| " Data extracted from surgery and the initial 48 hours postoperatively included gender, age, supratentorial versus infratentorial craniotomy, type of anesthesia (general versus monitored anesthesia care), intraoperative fentanyl dose, duration of anesthesia, antiemetic administration intraoperatively and postoperatively, and incidence of postoperative nausea, emesis, and opioid use." | 5.08 | Postoperative nausea and vomiting. A retrospective analysis in patients undergoing elective craniotomy. ( Borel, CO; el-Moalem, HE; Fabling, JM; Gan, TJ; Guy, J; Warner, DS, 1997) |
| " This difference was still significant when controlling for age, body weight, history of motion sickness, previous PONV episodes, duration of anesthesia, and intraoperative fentanyl consumption using a logistic model." | 5.08 | Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting. ( Finco, G; Gottin, L; Grosso, S; Ischia, S; Mosaner, W; Pinaroli, AM; Polati, E; Verlato, G, 1997) |
| "At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy." | 5.07 | Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993) |
| "One hundred and sixty-four patients scheduled for elective termination of pregnancy under general anaesthesia were randomly assigned to receive one of three different supplements to propofol and oxygen in nitrous oxide anaesthesia: 0." | 5.07 | Opioid supplementation to propofol anaesthesia for outpatient abortion: a comparison between alfentanil, fentanyl and placebo. ( Andreen, M; Davidson, S; Jakobsson, J; Westgreen, M, 1991) |
| "Respiratory effects, nausea, somnolence, and pruritus were compared during a 48-hr period of continuous epidural morphine (n = 34) and fentanyl (n = 32) infusion in 66 patients following elective total replacement of the hip or knee joint." | 5.07 | Side effects during continuous epidural infusion of morphine and fentanyl. ( Berghausen, EJ; Dumont, SW; Heine, MF; Huang, KC; Schroeder, JA; Tsueda, K; Vogel, RL; White, MJ, 1992) |
| "All communications on the use of transdermal fentanyl as well as the recommendations of the manufacturer include the direction that patients should be titrated with a short-acting narcotic to control their cancer pain before they are converted to a fentanyl transdermal therapeutic system (TTS)." | 5.07 | Transdermal fentanyl in uncontrolled cancer pain: titration on a day-to-day basis as a procedure for safe and effective dose finding--a pilot study in 20 patients. ( Korte, W; Morant, R, 1994) |
| "In two prospective, randomized studies the frequency of headache, nausea, vomiting, and analgesic requirement during the first postoperative 24 h was observed in order to study differences between the sexes and the inhalation anesthetics halothane, enflurane, isoflurane, or balanced anesthesia with enflurane/alfentanil." | 5.06 | [Complaints in the postoperative phase related to anesthetics]. ( Fritz, T; Guggenberger, E; Guggenberger, H; Heuser, D; Warth, H; Wittkowski, KM, 1988) |
| " (n=54) or the combination droperidol-fentanylatropine (n=123) complain significantly less frequently about nausea and/or vomiting than patients receiving pentazocine-atropine (n=64)." | 5.05 | [The influence of the premedication on subjective postanaesthetic complaints in out-patients (author's transl)]. ( Kreienbühl, G, 1980) |
| " Patients in whom anesthesia was induced with etomidate had a greater incidence of pain on injection and myoclonus and a lesser incidence of apnea than patients in whom anesthesia was induced with thiopental." | 5.05 | Etomidate versus thiopental for induction of anesthesia. ( Giese, JL; Nelissen, RH; Pace, NL; Stanley, TH; Stockham, RJ, 1985) |
| "The findings indicate comparability of transdermal buprenorphine and transdermal fentanyl for pain measures with significantly fewer adverse events (nausea and treatment discontinuation due to adverse events) caused by transdermal buprenorphine." | 4.88 | Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain. ( Aune, D; Hernandez, AV; Kleijnen, J; Misso, K; Riemsma, R; Truyers, C; Wolff, RF, 2012) |
| "Transdermal fentanyl is a useful opioid-agonist for the treatment of moderate to severe chronic cancer pain." | 4.81 | Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control. ( Muijsers, RB; Wagstaff, AJ, 2001) |
| " However, PCA with sufentanil was more frequently discontinued due to nausea or vomiting compared to fentanyl-based PCA." | 3.96 | Comparison of the Effects of Sufentanil and Fentanyl in Intravenous Patient-Controlled Analgesia after Pediatric Moyamoya Surgery: A Retrospective Study. ( Jang, YE; Kim, EH; Kim, HS; Kim, JT; Lee, JH; Lim, L, 2020) |
| "The fentanyl transdermal matrix patch is approved in Japan for the management of moderate to severe cancer-related pain in adults." | 3.74 | Fentanyl transdermal matrix patch (Durotep MT patch; Durogesic DTrans; Durogesic SMAT): in adults with cancer-related pain. ( Hoy, SM; Keating, GM, 2008) |
| "The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement." | 3.74 | [Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine]. ( Abe, F; Furuya, A; Nagamine, N; Nonaka, A; Suzuki, S, 2007) |
| "To determine the incidence of nausea and vomiting after radiofrequency catheter ablation, determine factors related to nausea and vomiting, and evaluate the antiemetic efficacy of promethazine given during the procedure." | 3.69 | Nausea and vomiting in patients undergoing radiofrequency catheter ablation. ( Funk, M; Nyström, KV; Tyndall, A, 1997) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 3.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| "The administration of alfentanil by continuous infusion as supplementation to nitrous oxide for shortlasting anesthesias has been studied in 51 patients." | 3.66 | Continuous infusion of alfentanil. ( Booij, LH; Pelgrom, R; Steegers, PA, 1982) |
| "PCA-fentanyl consumption was significantly higher in Group 1 compared to Group 2 and 3 (P = ." | 3.30 | Comparison of the Efficacies of Three Different Intrathecal Doses of Morphine in Achieving Postcesarean Delivery Analgesia. ( Kocamanoğlu, İS; Tamdoğan, İ; Turunç, E, 2023) |
| "The rates of respiratory depression (1." | 3.11 | Effect of additional equipotent fentanyl or sufentanil administration on recovery profiles during propofol-remifentanil-based anaesthesia in patients undergoing gynaecologic laparoscopic surgery: a randomized clinical trial. ( Huang, D; Huang, J; Jian, Q; Li, P; Ma, J; Xie, H; Zeng, W; Zhang, C, 2022) |
| " Safety assessments, including adverse event (AE) monitoring, occurred from dosing through Day 7." | 2.84 | Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a single ascending dose study in opioid-naïve healthy volunteers. ( Koch, C; Nalamachu, S; Oh, DA; Parikh, N; Rauck, R; Singla, N; Vetticaden, S; Yu, J, 2017) |
| "Modafinil 200 mg was administered to the treatment group patients 1 h before sedation/analgesia." | 2.75 | Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010) |
| "The purpose of this retrospective study was to determine whether epidural fentanyl-bupivacaine patient-controlled analgesia (PCA) was more efficacious and had fewer adverse effects than epidural or intravenous morphine PCA." | 2.71 | Efficacy and adverse effects of patient-controlled epidural or intravenous analgesia after major surgery. ( Hu, JS; Liew, C; Lui, PW; Teng, YH; Tsai, SK, 2004) |
| "This study examined the intra-operative and postoperative characteristics of a remifentanil infusion alone, or intermittent fentanyl bolus admistration combined with a propofol infusion, for the anaesthetic management of patients undergoing shock wave lithotripsy." | 2.70 | A comparison of anaesthetic techniques for shock wave lithotripsy: the use of a remifentanil infusion alone compared to intermittent fentanyl boluses combined with a low dose propofol infusion. ( Blanc, I; Brauer, P; Burmeister, MA; Graefen, M; Standl, TG; Wintruff, M, 2002) |
| "TTS fentanyl was shown to be an effective, safe and simple method for long-term pain relief in cancer patients and presents an interesting novel option in the treatment of cancer pain." | 2.68 | Transdermal fentanyl in combination with initial intravenous dose titration by patient-controlled analgesia. ( Lehmann, KA; Zech, DF, 1995) |
| "Midazolam was associated with impairment of performance on the TDT and DSST after premedication administration and 15 (TDT and DSST) and 30 (DSST) min after postanesthesia care unit (PACU) arrival." | 2.68 | Midazolam premedication increases sedation but does not prolong discharge times after brief outpatient general anesthesia for laparoscopic tubal sterilization. ( Hussain, A; Richardson, MG; Wu, CL, 1997) |
| "Propofol, 2 mg/kg, was administered intravenously for induction of anesthesia and followed by propofol, 50 to 250 micrograms/kg/min, for maintenance anesthesia." | 2.68 | Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery. ( Fowles, S; Jellish, WS; Leonetti, JP; Murdoch, JR, 1995) |
| "Pruritus was more pronounced within the first six hours in Group 1 and at 18 hr in Group 2." | 2.68 | Epidural morphine vs hydromorphone in post-caesarean section patients. ( Arellano, R; Carstoniu, J; Halpern, SH; O'Leary, G; Preston, R; Roger, S; Sandler, A, 1996) |
| "This study was designed to determine and compare the dose-response characteristics, speed of onset, and relative potency of single-dose epidural fentanyl (F) and sufentanil (S) for postoperative pain relief." | 2.68 | A randomized, double-blind, dose-response comparison of epidural fentanyl versus sufentanil analgesia after cesarean section. ( Grass, JA; Harris, AP; Michitsch, R; Sakima, NT; Schmidt, R; Zuckerman, RL, 1997) |
| "Nausea was noted in 61% of the parturients in the lateral group and in 22% (P < 0." | 2.67 | Posture and the spread of hyperbaric bupivacaine in parturients using the combined spinal epidural technique. ( Morgan, B; Patel, M; Samsoon, G; Swami, A, 1993) |
| "Oral transmucosal fentanyl citrate (OTFC) is a novel lozenge dosage form of fentanyl used for premedication." | 2.67 | Oral transmucosal fentanyl citrate premedication in patients undergoing outpatient dermatologic procedures. ( Bezzant, JL; Gerwels, JW; Le Maire, L; Pauley, LF; Streisand, JB, 1994) |
| "Postoperative pain was scored with Hannalah and Broadman's score (0 to 10) 2, 4, 8 and 24 h after the caudal block." | 2.67 | [Caudal block in children: analgesia and respiratory effect of the combination bupivacaine-fentanyl]. ( Ecoffey, C; Moine, P, 1992) |
| "Postoperative pain was reported in 35% of patients, with no significant difference between treated and control patients." | 2.67 | Prophylactic paracetamol for analgesia after vaginal termination of pregnancy. ( Ashley, J; Cade, L, 1993) |
| " The low- and high-dose nalbuphine groups clinically resembled the fentanyl group in terms of dosing frequency and patients' self-ratings of postoperative analgesia." | 2.66 | A comparison of clinical and psychological effects of fentanyl and nalbuphine in ambulatory gynecologic patients. ( Earls, F; Garfield, FB; Garfield, JM; Philip, BK; Roaf, E, 1987) |
| "Isoflurane and fentanyl have been compared as anaesthetic agents for outpatient laparoscopy." | 2.66 | Isoflurane v fentanyl for outpatient laparoscopy. ( Dodgson, MS; Rising, S; Steen, PA, 1985) |
| "One-hundred and eighty patients undergoing elective abdominal hysterectomy were anaesthetized in random order with isoflurane, enflurane or fentanyl in combination with nitrous oxide and oxygen." | 2.66 | Nausea and vomiting after general anaesthesia with isoflurane, enflurane or fentanyl in combination with nitrous oxide and oxygen. ( Erkola, O; Hovorka, J; Korttila, K, 1988) |
| "Fentanyl ITS was equally effective when compared with morphine IV PCA for patient subpopulations (age, surgery type, and BMI)." | 2.44 | The safety and efficacy of fentanyl iontophoretic transdermal system compared with morphine intravenous patient-controlled analgesia for postoperative pain management: an analysis of pooled data from three randomized, active-controlled clinical studies. ( Damaraju, CV; Hewitt, DJ; Kershaw, P; Siccardi, M; Viscusi, ER, 2007) |
| "Uterine fibroid embolization (UFE) procedures performed from 2013 to 2019 were reviewed." | 1.91 | Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols. ( Brahler, T; Hastings, G; Howles-Banerji, G; Kotton, M; Price, A; Singer, D; Wrenn, SJ, 2023) |
| "Although opioids have been shown to be effective for cancer pain, opioid-induced adverse events (AEs) are common." | 1.91 | Prevalence of opioid-induced adverse events across opioids commonly used for analgesic treatment in Japan: a multicenter prospective longitudinal study. ( Arakawa, S; Chiu, SW; Hiratsuka, Y; Hirayama, H; Inoue, A; Ishiki, H; Kosugi, K; Kubo, E; Matsuda, Y; Miyashita, M; Morita, T; Natsume, M; Nishijima, K; Ouchi, K; Sato, M; Satomi, E; Shigeno, T; Shimizu, M; Shimoda, M; Shimoi, T; Tagami, K; Yamaguchi, T; Yokomichi, N, 2023) |
| "7%) reduced benzodiazepines dosage when prescribing potent opioids." | 1.56 | Strong opioids and non-cancer chronic pain in Catalonia. An analysis of the family physicians prescription patterns. ( Adriyanov, B; Álvarez Carrera, MA; Dürsteler, C; Perelló Bratescu, A; Riera Nadal, N; Sisó-Almirall, A, 2020) |
| "Fentanyl was administered at a dose of 0." | 1.42 | [Side Effects of Continuous Fentanyl Infusion for Postoperative Pain Relief in Children]. ( Ikejima, N; Kabara, S; Kagawa, T; Sueda, A; Takatsuji, S, 2015) |
| "IV-PCA provided timely, safe and useful analgesia for patients with severe breakthrough pain and may be useful to help titration of opioids, weaning to oral analgesia and to decide for interventional procedures." | 1.40 | Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study. ( Ashmawi, HA; Cascudo, GM; de Santana Neto, J; Guimaraes, GM; Neto, JO; Sousa, AM, 2014) |
| "Lacking enough knowledge of pediatric cancer pain and pediatric dosage form of analgesics, current treatment of pediatric cancer pain in China is unsatisfactory." | 1.34 | [Feasibility to treat pediatric cancer pain with analgesics for adults and their efficacy]. ( Lin, H; Ling, JY; Luo, WB; Sun, XF; Xia, Y; Zhen, ZJ; Zheng, L, 2007) |
| "The risk of respiratory depression increased with age." | 1.32 | Side effects of opioids during short-term administration: effect of age, gender, and race. ( Baumgarten, M; Boston, R; Carr, DB; Cepeda, MS; Farrar, JT; Strom, BL, 2003) |
| "To assess the effect of opioid substitution (substituting one member of the opioid class for another) on the incidence and severity of adverse effects in palliative care patients who experience unacceptable, refractory adverse effects when taking an opioid drug." | 1.30 | Opioid substitution to reduce adverse effects in cancer pain management. ( Ashby, MA; Jackson, KA; Martin, P, 1999) |
| "Severe hyponatremia has been described after elective surgery with subsequent permanent brain damage." | 1.30 | Severe hyponatremia after transsphenoidal surgery for pituitary adenomas. ( Boehnert, M; Buchfelder, M; Fahlbusch, R; Gross, P; Henig, A; Hensen, J, 1998) |
Research
Studies (129)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (20.16) | 18.7374 |
| 1990's | 50 (38.76) | 18.2507 |
| 2000's | 27 (20.93) | 29.6817 |
| 2010's | 18 (13.95) | 24.3611 |
| 2020's | 8 (6.20) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Zhang, C | 1 |
| Huang, D | 1 |
| Zeng, W | 1 |
| Ma, J | 1 |
| Li, P | 1 |
| Jian, Q | 1 |
| Huang, J | 1 |
| Xie, H | 1 |
| Brant, AR | 1 |
| Reeves, MF | 1 |
| Ye, PP | 1 |
| Scott, RK | 1 |
| Floyd, S | 1 |
| Tefera, E | 1 |
| Lotke, PS | 1 |
| LA Via, L | 3 |
| Santonocito, C | 3 |
| Bartolotta, N | 3 |
| Lanzafame, B | 3 |
| Morgana, A | 3 |
| Continella, C | 3 |
| Cirica, G | 3 |
| Astuto, M | 3 |
| Sanfilippo, F | 3 |
| Hastings, G | 2 |
| Brahler, T | 2 |
| Howles-Banerji, G | 2 |
| Kotton, M | 2 |
| Price, A | 2 |
| Singer, D | 2 |
| Wrenn, SJ | 2 |
| Tamdoğan, İ | 1 |
| Turunç, E | 1 |
| Kocamanoğlu, İS | 1 |
| Hiratsuka, Y | 1 |
| Tagami, K | 1 |
| Inoue, A | 1 |
| Sato, M | 1 |
| Matsuda, Y | 1 |
| Kosugi, K | 1 |
| Kubo, E | 1 |
| Natsume, M | 1 |
| Ishiki, H | 1 |
| Arakawa, S | 1 |
| Shimizu, M | 1 |
| Yokomichi, N | 1 |
| Chiu, SW | 1 |
| Shimoda, M | 1 |
| Hirayama, H | 1 |
| Nishijima, K | 1 |
| Ouchi, K | 1 |
| Shimoi, T | 1 |
| Shigeno, T | 1 |
| Yamaguchi, T | 1 |
| Miyashita, M | 1 |
| Morita, T | 1 |
| Satomi, E | 1 |
| Perelló Bratescu, A | 1 |
| Adriyanov, B | 1 |
| Dürsteler, C | 1 |
| Sisó-Almirall, A | 1 |
| Álvarez Carrera, MA | 1 |
| Riera Nadal, N | 1 |
| Lim, L | 1 |
| Jang, YE | 1 |
| Kim, EH | 1 |
| Lee, JH | 1 |
| Kim, JT | 1 |
| Kim, HS | 1 |
| Rauck, R | 1 |
| Oh, DA | 1 |
| Parikh, N | 1 |
| Koch, C | 1 |
| Singla, N | 1 |
| Yu, J | 1 |
| Nalamachu, S | 1 |
| Vetticaden, S | 1 |
| Clivatti, J | 1 |
| Siddiqui, N | 1 |
| Goel, A | 1 |
| Shaw, M | 1 |
| Crisan, I | 1 |
| Carvalho, JC | 1 |
| Martin, CM | 1 |
| Sousa, AM | 1 |
| de Santana Neto, J | 1 |
| Guimaraes, GM | 1 |
| Cascudo, GM | 1 |
| Neto, JO | 1 |
| Ashmawi, HA | 1 |
| Kim, K | 1 |
| Kim, WJ | 1 |
| Choi, DK | 1 |
| Lee, YK | 1 |
| Choi, IC | 1 |
| Sim, JY | 1 |
| Sundarathiti, P | 1 |
| Sangdee, N | 1 |
| Sangasilpa, I | 1 |
| Prayoonhong, W | 1 |
| Papoun, S | 1 |
| Thronæs, M | 1 |
| Popper, L | 1 |
| Eeg, M | 1 |
| Jaatun, E | 1 |
| Kvitberg, M | 1 |
| Kaasa, S | 1 |
| Kabara, S | 1 |
| Kagawa, T | 1 |
| Ikejima, N | 1 |
| Takatsuji, S | 1 |
| Sueda, A | 1 |
| Garnock-Jones, KP | 1 |
| Choi, GJ | 1 |
| Kang, H | 1 |
| Ahn, EJ | 1 |
| Oh, JI | 1 |
| Baek, CW | 1 |
| Jung, YH | 1 |
| Kim, JY | 1 |
| Choi, JW | 1 |
| Joo, JD | 1 |
| Kim, DW | 1 |
| In, JH | 1 |
| Kwon, SY | 1 |
| Seo, K | 1 |
| Han, D | 1 |
| Cheon, GY | 1 |
| Jung, HS | 1 |
| Khanna, A | 1 |
| Saxena, R | 1 |
| Dutta, A | 1 |
| Ganguly, N | 1 |
| Sood, J | 1 |
| Smith, I | 1 |
| Walley, G | 1 |
| Bridgman, S | 1 |
| Hoy, SM | 1 |
| Keating, GM | 1 |
| Wirz, S | 1 |
| Wittmann, M | 1 |
| Schenk, M | 1 |
| Schroeck, A | 1 |
| Schaefer, N | 1 |
| Mueller, M | 1 |
| Standop, J | 1 |
| Kloecker, N | 1 |
| Nadstawek, J | 1 |
| Cai, Q | 1 |
| Huang, H | 1 |
| Sun, X | 1 |
| Xia, Z | 1 |
| Li, Y | 1 |
| Lin, X | 1 |
| Guo, Y | 1 |
| Galvin, E | 1 |
| Boesjes, H | 1 |
| Hol, J | 1 |
| Ubben, JF | 1 |
| Klein, J | 1 |
| Verbrugge, SJ | 1 |
| Lennernäs, B | 1 |
| Frank-Lissbrant, I | 1 |
| Lennernäs, H | 1 |
| Kälkner, KM | 1 |
| Derrick, R | 1 |
| Howell, J | 1 |
| Minkowski, CP | 1 |
| Epstein, D | 1 |
| Frost, JJ | 1 |
| Gorelick, DA | 1 |
| Hosokawa, Y | 1 |
| Morisaki, H | 1 |
| Nakatsuka, I | 1 |
| Hashiguchi, S | 1 |
| Miyakoshi, K | 1 |
| Tanaka, M | 1 |
| Yoshimura, Y | 1 |
| Takeda, J | 1 |
| Wolff, RF | 1 |
| Aune, D | 1 |
| Truyers, C | 1 |
| Hernandez, AV | 1 |
| Misso, K | 1 |
| Riemsma, R | 1 |
| Kleijnen, J | 1 |
| Russell, T | 1 |
| Mitchell, C | 1 |
| Paech, MJ | 1 |
| Pavy, T | 2 |
| Yao, L | 1 |
| Wang, T | 1 |
| Yang, B | 1 |
| Burmeister, MA | 1 |
| Brauer, P | 1 |
| Wintruff, M | 1 |
| Graefen, M | 1 |
| Blanc, I | 1 |
| Standl, TG | 1 |
| Obara, M | 1 |
| Sawamura, S | 1 |
| Satoh, Y | 1 |
| Chinzei, M | 1 |
| Sekiyama, H | 1 |
| Tamai, H | 1 |
| Yamamoto, H | 1 |
| Hanaoka, K | 1 |
| Cepeda, MS | 2 |
| Farrar, JT | 1 |
| Baumgarten, M | 1 |
| Boston, R | 1 |
| Carr, DB | 2 |
| Strom, BL | 1 |
| Zeng, L | 1 |
| Wu, X | 1 |
| Ma, Q | 1 |
| Su, Y | 1 |
| Teng, YH | 1 |
| Hu, JS | 1 |
| Tsai, SK | 1 |
| Liew, C | 1 |
| Lui, PW | 1 |
| Vicente, JM | 1 |
| Guasch, EV | 1 |
| Bermejo, JM | 1 |
| Gilsanz, F | 1 |
| Lin, CS | 1 |
| Lu, G | 1 |
| Ruan, LY | 1 |
| Gu, MN | 1 |
| Kjaer, K | 1 |
| Comerford, M | 1 |
| Kondilis, L | 1 |
| DiMaria, L | 1 |
| Abramovitz, S | 1 |
| Kiselev, M | 1 |
| Samuels, J | 1 |
| Gadalla, F | 1 |
| Leighton, BL | 1 |
| Lu, DP | 1 |
| Lu, WI | 1 |
| Ko, JS | 1 |
| Kim, CS | 1 |
| Cho, HS | 1 |
| Choi, DH | 1 |
| Vasudevan, A | 1 |
| Snowman, CE | 1 |
| Sundar, S | 1 |
| Sarge, TW | 1 |
| Hess, PE | 1 |
| Zhen, ZJ | 1 |
| Sun, XF | 1 |
| Xia, Y | 1 |
| Ling, JY | 1 |
| Zheng, L | 1 |
| Luo, WB | 1 |
| Lin, H | 1 |
| Mahar, PJ | 1 |
| Rana, JA | 1 |
| Kennedy, CS | 1 |
| Christopher, NC | 1 |
| Viscusi, ER | 1 |
| Siccardi, M | 1 |
| Damaraju, CV | 1 |
| Hewitt, DJ | 1 |
| Kershaw, P | 1 |
| Nonaka, A | 1 |
| Suzuki, S | 1 |
| Nagamine, N | 1 |
| Furuya, A | 1 |
| Abe, F | 1 |
| Darwish, M | 1 |
| Kirby, M | 1 |
| Jiang, JG | 1 |
| Tracewell, W | 1 |
| Robertson, P | 1 |
| Scamman, FL | 1 |
| Ghoneim, MM | 1 |
| Korttila, K | 3 |
| Welchew, EA | 1 |
| Steegers, PA | 1 |
| Booij, LH | 1 |
| Pelgrom, R | 1 |
| Smith, M | 1 |
| Kroll, D | 1 |
| Breckenridge, J | 1 |
| Kreienbühl, G | 1 |
| Jellish, WS | 2 |
| Leonetti, JP | 2 |
| Murdoch, JR | 2 |
| Fowles, S | 2 |
| Zech, DF | 1 |
| Lehmann, KA | 1 |
| Watts, RW | 1 |
| Fletcher, IA | 1 |
| Kiroff, GK | 1 |
| Weber, C | 1 |
| Owen, H | 1 |
| Plummer, JL | 1 |
| Gerwels, JW | 1 |
| Bezzant, JL | 1 |
| Le Maire, L | 1 |
| Pauley, LF | 1 |
| Streisand, JB | 1 |
| Howell, PR | 1 |
| Gambling, DR | 1 |
| McMorland, G | 1 |
| Douglas, MJ | 1 |
| Korte, W | 1 |
| Morant, R | 1 |
| Monagle, J | 1 |
| Wongprasartsuk, P | 1 |
| Shearer, W | 1 |
| Patel, M | 1 |
| Samsoon, G | 1 |
| Swami, A | 1 |
| Morgan, B | 1 |
| Hayashi, H | 1 |
| Nishiuchi, T | 1 |
| Tamura, H | 1 |
| Takeda, K | 1 |
| Cade, L | 2 |
| Ashley, J | 1 |
| Hovorka, J | 2 |
| Kallela, H | 1 |
| Delogu, G | 1 |
| Tomasello, C | 1 |
| Tellan, G | 1 |
| Pennacchiotti, ML | 1 |
| Marandola, M | 1 |
| Vecchia, P | 1 |
| Gonzalez, F | 1 |
| Granados, V | 1 |
| Cuervo, R | 1 |
| Halpern, SH | 1 |
| Arellano, R | 1 |
| Preston, R | 1 |
| Carstoniu, J | 1 |
| O'Leary, G | 1 |
| Roger, S | 1 |
| Sandler, A | 1 |
| Lauretti, GR | 1 |
| Azevedo, VM | 1 |
| Mendham, JE | 1 |
| Mather, SJ | 1 |
| Epstein, RH | 1 |
| Mendel, HG | 1 |
| Witkowski, TA | 1 |
| Waters, R | 1 |
| Guarniari, KM | 1 |
| Marr, AT | 1 |
| Lessin, JB | 1 |
| Lien, CA | 1 |
| Hemmings, HC | 1 |
| Belmont, MR | 1 |
| Abalos, A | 1 |
| Hollmann, C | 1 |
| Kelly, RE | 1 |
| Claxton, AR | 1 |
| McGuire, G | 1 |
| Chung, F | 1 |
| Cruise, C | 1 |
| Padda, GS | 1 |
| Cruz, OA | 1 |
| Krock, JL | 1 |
| Reinhart, DJ | 1 |
| Goldberg, ME | 1 |
| Roth, JV | 1 |
| Dua, R | 1 |
| Nevo, I | 1 |
| Klein, KW | 1 |
| Torjman, M | 1 |
| Vekeman, D | 1 |
| Richardson, MG | 1 |
| Wu, CL | 1 |
| Hussain, A | 1 |
| Grass, JA | 1 |
| Sakima, NT | 1 |
| Schmidt, R | 1 |
| Michitsch, R | 1 |
| Zuckerman, RL | 1 |
| Harris, AP | 1 |
| Polati, E | 1 |
| Verlato, G | 1 |
| Finco, G | 1 |
| Mosaner, W | 1 |
| Grosso, S | 1 |
| Gottin, L | 1 |
| Pinaroli, AM | 1 |
| Ischia, S | 1 |
| Morimoto, Y | 1 |
| Matsumoto, S | 1 |
| Nakamura, M | 1 |
| Makino, A | 1 |
| Tamura, T | 1 |
| Oka, H | 1 |
| Shimizu, K | 1 |
| Miyauchi, Y | 1 |
| Fabling, JM | 1 |
| Gan, TJ | 1 |
| Guy, J | 1 |
| Borel, CO | 1 |
| el-Moalem, HE | 1 |
| Warner, DS | 1 |
| Tsui, SL | 1 |
| Lee, DK | 1 |
| Ng, KF | 1 |
| Chan, TY | 1 |
| Chan, WS | 1 |
| Lo, JW | 1 |
| Tyndall, A | 1 |
| Nyström, KV | 1 |
| Funk, M | 1 |
| Boehnert, M | 1 |
| Hensen, J | 1 |
| Henig, A | 1 |
| Fahlbusch, R | 1 |
| Gross, P | 1 |
| Buchfelder, M | 1 |
| Raeder, JC | 1 |
| Mjåland, O | 1 |
| Aasbø, V | 1 |
| Grøgaard, B | 1 |
| Buanes, T | 1 |
| Koyama, S | 1 |
| Koh, H | 1 |
| Noda, K | 1 |
| Tagami, N | 1 |
| Asada, A | 1 |
| Eberhart, LH | 1 |
| Döring, HJ | 1 |
| Holzrichter, P | 1 |
| Roscher, R | 1 |
| Seeling, W | 1 |
| Song, D | 1 |
| Whitten, CW | 1 |
| White, PF | 2 |
| Yu, SY | 1 |
| Zarate, E | 1 |
| Ashby, MA | 1 |
| Martin, P | 1 |
| Jackson, KA | 1 |
| Carrero Cardenal, EJ | 1 |
| Valero Castell, R | 1 |
| Roux Carmona, C | 1 |
| Lapena Bayo, C | 1 |
| Ortells Ribé, J | 1 |
| Artigas Rubio, X | 1 |
| Woodhouse, A | 1 |
| Ward, EM | 1 |
| Mather, LE | 1 |
| Lo, WK | 1 |
| Chong, JL | 1 |
| Chen, LH | 1 |
| Fernández-Guisasola, J | 1 |
| García del Valle, S | 1 |
| Gómez-Arnau, JI | 1 |
| Vercauteren, MP | 1 |
| Van de Velde, M | 1 |
| Dreher, JK | 1 |
| Nemeth, D | 1 |
| Limb, R | 1 |
| Sánchez-Conde, P | 1 |
| Nicolás, J | 1 |
| Rodríguez, J | 1 |
| García-Castaño, M | 1 |
| del Barrio, E | 1 |
| Muriel, C | 1 |
| Gómez, P | 1 |
| Echevarría, M | 1 |
| Calderón, J | 1 |
| Caba, F | 1 |
| Martínez, A | 1 |
| Rodríguez, R | 1 |
| Muijsers, RB | 1 |
| Wagstaff, AJ | 1 |
| Arnér, S | 1 |
| Gordon, E | 1 |
| Van De Walle, J | 1 |
| Lauwers, P | 1 |
| Adriaensen, H | 1 |
| Freye, E | 1 |
| Rose, DK | 1 |
| Cohen, MM | 1 |
| Soutter, DI | 1 |
| Moine, P | 1 |
| Ecoffey, C | 1 |
| Bloomfield, EL | 1 |
| Vincent, RD | 1 |
| Chestnut, DH | 2 |
| Choi, WW | 2 |
| Ostman, PL | 1 |
| Bates, JN | 2 |
| Ross, AW | 1 |
| White, MJ | 1 |
| Berghausen, EJ | 1 |
| Dumont, SW | 1 |
| Tsueda, K | 1 |
| Schroeder, JA | 1 |
| Vogel, RL | 1 |
| Heine, MF | 1 |
| Huang, KC | 1 |
| Coe, A | 1 |
| Sarginson, R | 1 |
| Smith, MW | 1 |
| Donnelly, RJ | 1 |
| Russell, GN | 1 |
| Jakobsson, J | 1 |
| Davidson, S | 1 |
| Andreen, M | 1 |
| Westgreen, M | 1 |
| Rosenblum, M | 1 |
| Weller, RS | 1 |
| Conard, PL | 1 |
| Falvey, EA | 1 |
| Gross, JB | 1 |
| Lytle, SA | 1 |
| Goldsmith, DM | 1 |
| Neuendorf, TL | 1 |
| Lowry, ME | 1 |
| Fruergaard, K | 1 |
| Jenstrup, M | 1 |
| Schierbeck, J | 1 |
| Wiberg-Jørgensen, F | 1 |
| Goundrey, J | 1 |
| Wetchler, BV | 1 |
| Alexander, CD | 1 |
| Shariff, MS | 1 |
| Gaudzels, GM | 1 |
| Garfield, JM | 1 |
| Garfield, FB | 1 |
| Philip, BK | 1 |
| Earls, F | 1 |
| Roaf, E | 1 |
| Coe, V | 1 |
| Shafer, A | 1 |
| Sung, ML | 1 |
| Guggenberger, H | 1 |
| Fritz, T | 1 |
| Guggenberger, E | 1 |
| Warth, H | 1 |
| Wittkowski, KM | 1 |
| Heuser, D | 1 |
| Rising, S | 1 |
| Dodgson, MS | 1 |
| Steen, PA | 1 |
| Erkola, O | 1 |
| Vandewalker, GE | 1 |
| Owen, CL | 1 |
| Gaskey, NJ | 1 |
| Ferriero, L | 1 |
| Pournaras, L | 1 |
| Seecof, J | 1 |
| Klein, DS | 1 |
| Klein, PW | 1 |
| Mahaley, MS | 1 |
| Carcey, J | 1 |
| Rosencher, N | 1 |
| Guillaume, F | 1 |
| Berthet, J | 1 |
| Giese, JL | 1 |
| Stockham, RJ | 1 |
| Stanley, TH | 1 |
| Pace, NL | 1 |
| Nelissen, RH | 1 |
| Vandam, LD | 1 |
| Bernhoff, A | 1 |
| Jakt, L | 1 |
| Graham, TP | 1 |
| Atwood, GF | 1 |
| Werner, B | 1 |
| Norris, W | 1 |
| Telfer, AB | 1 |
| Morrison, JD | 1 |
| Loan, WB | 1 |
| Dundee, JW | 1 |
| McDowell, SA | 1 |
| Brown, SS | 1 |
| Shamash, R | 1 |
| Gutman, D | 1 |
| Birkhan, J | 1 |
| Knape, H | 1 |
Clinical Trials (16)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gabapentin as an Adjunct for Pain Management During Dilation and Evacuation: A Double-blind Randomized Controlled Trial[NCT03635905] | Phase 4 | 130 participants (Actual) | Interventional | 2017-05-26 | Completed | ||
| A Phase 1, Open-label, Randomized, Single Ascending Dose Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fentanyl Sublingual Spray and Fentanyl Citrate Intravenous (IV) in Opioid Naive Subjects[NCT02576353] | Phase 1 | 50 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study[NCT05071352] | Phase 3 | 60 participants (Anticipated) | Interventional | 2021-10-01 | Recruiting | ||
| A Dose Titrated Clinical Trial With a Placebo-controlled, Double-blind, Randomised, Cross-over Phase to Demonstrate the Efficacy of 400 μg Intranasal Fentanyl (INFS) Dose Strength, and to Evaluate 12 Weeks Safety and Nasal Tolerability of All Dose Strengt[NCT01429051] | Phase 3 | 46 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Intravenous Lidocaine for Effective Pain Relief After Thyroidectomy: a Prospective, Randomized, Double-blind, Placebo-controlled Study[NCT01608360] | Phase 4 | 56 participants (Anticipated) | Interventional | 2011-07-31 | Recruiting | ||
| Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs[NCT04741880] | Phase 2/Phase 3 | 66 participants (Anticipated) | Interventional | 2021-06-17 | Recruiting | ||
| Comparison of the Effect of Intra-articular Administration of 2% Ropivacaine vs. 7.5% Ropivacaine as an Analgesic in the Immediate Postoperative Period of Knee Arthroscopy in Acute Injuries at the ABC Medical Center[NCT05807945] | Phase 4 | 68 participants (Actual) | Interventional | 2020-04-01 | Completed | ||
| A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102] | Phase 4 | 105 participants (Actual) | Interventional | 2016-02-29 | Terminated | ||
| Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597] | Phase 4 | 10 participants (Actual) | Interventional | 2017-07-29 | Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.) | ||
| Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461] | 137 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery[NCT02346110] | Phase 4 | 40 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| An Open Label Evaluation of the Safety and Clinical Utility of the Active, Separated System With Enhanced Controller (SSEC) Fentanyl 40 mcg for the Management of Acute Postoperative Pain in Pediatric Patients 12 to Less Than 18 Years of Age[NCT02395653] | Phase 3 | 71 participants (Actual) | Interventional | 2015-06-29 | Completed | ||
| Evaluating the Use of Sublingual Sufentanil in Patients With Suboxone Treatment Who Are Undergoing Ambulatory Surgery- a Case Series[NCT04716413] | Phase 4 | 3 participants (Actual) | Interventional | 2021-09-27 | Terminated (stopped due to Terminated early due to funding, lack of participants) | ||
| [NCT00440960] | Phase 4 | 0 participants | Interventional | Completed | |||
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Non-Interventional Pharmacogenetic Study of Patient / Proxy Controlled Analgesia in Children Undergoing Surgery[NCT01731873] | 182 participants (Actual) | Observational | 2012-01-17 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Efficacy Phase: General Impression (GI) Score at 60 Minutes After First Dose
"Participants assessed their general impression (GI) of treatment efficacy for treated BTP episodes at 60 minutes after first dose of study drug. The validated, categorical 5-point Verbal Rating Scale (VRS) was used for this assessment and scored as follows:~0 =poor;~1 =fair;~2 =good;~3 =very good;~4 =excellent." (NCT01429051)
Timeframe: During the efficacy phase (II), at each episode of breakthrough pain, 60 minutes after first dose of study drug.
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Intranasal Fentanyl Spray (INFS) | 1.9 |
| Placebo | 1.1 |
Induction Phase: Pain Intensity Difference at 10 Minutes (PID10) After Treatment
"During the efficacy phase participants assessed their pain intensity at each breakthrough pain (BTP) episode at 0 and 10 minutes after first dose using the 11-point Numerical Rating Scale (NRS) on a scale from 0 to 10, where 0 represents the absence of pain and 10 is worst possible pain. PID10 is calculated as the difference in pain intensity from time 0 to 10 minutes. A positive value is a decrease (improvement) of the pain; a ≥ 2-point difference is considered as clinically important." (NCT01429051)
Timeframe: During the efficacy phase (II), at each episode of breakthrough pain, at 0 and 10 minutes after first dose of study drug.
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Intranasal Fentanyl Spray (INFS) | 2.5 |
| Placebo | 1.4 |
Efficacy Phase: Pain Intensity Difference (PID) at 5, 30, and 60 Minutes After First Dose of Study Drug
"During the efficacy phase participants assessed their pain intensity at each breakthrough pain (BTP) episode at 0, 5, 30 and 60 minutes after first dose using the 11-point Numerical Rating Scale (NRS) on a scale from 0 to 10, where 0 represents the absence of pain and 10 is worst possible pain. PID is calculated as the difference in pain intensity from time 0 to each time point. A positive value is a decrease (improvement) of the pain; a ≥ 2-point difference is considered as clinically important." (NCT01429051)
Timeframe: During the efficacy phase (II) each episode of breakthrough pain, at 0, 5, 30 and 60 minutes after study drug.
| Intervention | units on a scale (Least Squares Mean) | ||
|---|---|---|---|
| PID at 5 minutes | PID at 30 minutes | PID at 60 minutes | |
| Intranasal Fentanyl Spray (INFS) | 1.3 | 3.0 | 3.3 |
| Placebo | 0.8 | 1.8 | 2.2 |
Efficacy Phase: Proportion of BTP Episodes With a Positive Response Defined as a ≥ 1, 2 or 3 Point Reduction in Pain Intensity
"Overall responder rate is defined as the proportion of breakthrough pain (BTP) episodes with a positive response to treatment. The following definitions of a positive response were analyzed: • greater than or equal to 1 point reduction in pain intensity (PI) from time 0, • greater than or equal to 2 point reduction in PI from time 0, and • greater than or equal to 3 point reduction in PI from time 0. Pain intensity was assessed using the 11-point Numerical Rating Scale (NRS) on a scale from 0 to 10, where 0 represents the absence of pain and 10 is worst possible pain." (NCT01429051)
Timeframe: During the efficacy phase (II) each episode of breakthrough pain, at 0, 5, 30 and 60 minutes after study drug
| Intervention | proportion of breakthrough pain episodes (Number) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≥ 1 point reduction in PI at 5 minutes | ≥ 1 point reduction in PI at 10 minutes | ≥ 1 point reduction in PI at 30 minutes | ≥ 1 point reduction in PI at 60 minutes | ≥ 2 point reduction in PI at 5 minutes | ≥ 2 point reduction in PI at 10 minutes | ≥ 2 point reduction in PI at 30 minutes | ≥ 2 point reduction in PI at 60 minutes | ≥ 3 point reduction in PI at 5 minutes | ≥ 3 point reduction in PI at 10 minutes | ≥ 3 point reduction in PI at 30 minutes | ≥ 3 point reduction in PI at 60 minutes | |
| Intranasal Fentanyl Spray (INFS) | 0.61 | 0.74 | 0.81 | 0.86 | 0.33 | 0.51 | 0.60 | 0.65 | 0.18 | 0.32 | 0.45 | 0.50 |
| Placebo | 0.45 | 0.55 | 0.66 | 0.69 | 0.24 | 0.31 | 0.41 | 0.48 | 0.17 | 0.24 | 0.34 | 0.48 |
Efficacy Phase: Proportion of BTP Episodes With a Positive Response Defined as a ≥ 33% or 50% Reduction in Pain Intensity
"Overall responder rate is defined as the proportion of breakthrough pain (BTP) episodes with a positive response to treatment. The following definitions of a positive response were analyzed: • Greater than 33% reduction in PI from time 0; • Greater than or equal to 50% reduction in PI from time 0. Pain intensity was assessed using the 11-point Numerical Rating Scale (NRS) on a scale from 0 to 10, where 0 represents the absence of pain and 10 is worst possible pain." (NCT01429051)
Timeframe: During the efficacy phase (II) each episode of breakthrough pain, at 0, 5, 30 and 60 minutes after study drug
| Intervention | proportion of breakthrough pain episodes (Number) | |||||||
|---|---|---|---|---|---|---|---|---|
| > 33% reduction in PI at 5 minutes | > 33% reduction in PI at 10 minutes | > 33% reduction in PI at 30 minutes | > 33% reduction in PI at 60 minutes | ≥ 50% reduction in PI at 5 minutes | ≥ 50% reduction in PI at 10 minutes | ≥ 50% reduction in PI at 30 minutes | ≥ 50% reduction in PI at 60 minutes | |
| Intranasal Fentanyl Spray (INFS) | 0.23 | 0.44 | 0.55 | 0.58 | 0.11 | 0.31 | 0.49 | 0.52 |
| Placebo | 0.17 | 0.24 | 0.34 | 0.48 | 0.07 | 0.21 | 0.31 | 0.34 |
Efficacy Phase: Sum of Pain Intensity Differences (SPID0-60 and SPID0-30) Derived From PI Scores
"The SPID30 and SPID60 represent the average improvement in pain intensity over the 30 minute interval and 60 minute interval, respectively. SPIDt was calculated as the area under the curve (AUC) for Pain Intensity Difference over the time interval 0 to t minutes, respectively, divided by the length of the time interval (t minutes). A positive value is a decrease (improvement) of the pain.~Pain intensity was assessed at 0, 5, 30 and 60 minutes after study drug using the 11-point Numerical Rating Scale (NRS) on a scale from 0 to 10, where 0 represents the absence of pain and 10 is worst possible pain. PID is calculated as the difference in pain intensity from time 0 to each time point." (NCT01429051)
Timeframe: During the efficacy phase (II) each episode of breakthrough pain, at 0, 5, 30 and 60 minutes after study drug
| Intervention | units on a scale (Least Squares Mean) | |
|---|---|---|
| SPID30 | SPID60 | |
| Intranasal Fentanyl Spray (INFS) | 0.6 | 0.7 |
| Placebo | 0.4 | 0.5 |
Incidence of Improvement or Worsening in Nasal Mucosa Sign or Abnormality Score
Medical examination of the nasal cavity by rhinoscopy was performed by an oto-rhino-laryngologist before the start of study treatment and at 12 weeks. Signs and any abnormalities were observed for each nostril using the following 4 points assessment scale: • 0 =not present; • 1 =present in a mild degree; • 2 =present in a moderate degree; • 3 =present in a severe degree. A difference in score of 1 or more from Baseline to the end of treatment represented a worsening, while a negative value indicated an improvement of the observed clinical sign. The oto-rhino-laryngologist also assessed whether worsening of a sign was related to study drug. Assessments for both left and right nostrils are presented together. The incidence is calculated as the number of assessments (n) in the improvement or worsening category divided by the number of assessments with a non-missing score for the Nasal Mucosa or Abnormality assessment. Only those signs or abnormalities with n>0 were included (NCT01429051)
Timeframe: Baseline and at 12 weeks
| Intervention | proportion of nostril assessments (Number) | ||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Change of color: Improvement | Change of color: Worsening | Change of color: Worsening related to study drug | Inflammation: Improvement | Inflammation: Worsening | Inflammation: Worsening related to study drug | Sore nose: Improvement | Sore nose: Worsening | Sore nose: Worsening related to study drug | Ulceration: Improvement | Ulceration: Worsening | Ulceration: Worsening related to study drug | Dry nose: Improvement | Dry nose: Worsening | Dry nose: Worsening related to study drug | Runny nose: Improvement | Runny nose: Worsening | Runny nose: Worsening related to study drug | Stuffed nose: Improvement | Stuffed nose: Worsening | Stuffed nose: Worsening related to study drug | Oedema: Improvement | Oedema: Worsening | Oedema: Worsening related to study drug | Epistaxis: Improvement | Epistaxis: Worsening | Epistaxis: Worsening related to study drug | |
| Intranasal Fentanyl Spray (INFS) | 0.06 | 0.09 | 0.09 | 0.04 | 0.07 | 0.07 | 0.04 | 0.04 | 0.04 | NA | 0.04 | 0.04 | 0.09 | 0.06 | NA | 0.04 | 0.13 | 0.10 | 0.06 | 0.17 | 0.08 | 0.04 | 0.17 | 0.08 | 0.02 | 0.02 | 0.02 |
Number of Participants With Adverse Events (AEs)
The severity (intensity of each AE was assessed as mild (transient symptoms, no interference with daily activities), moderate (marked symptoms, moderate interference with daily activities), or severe (considerable interference with daily activities) by the investigator. Serious adverse events are defined as any untoward medical occurrence that at any dose results in death or is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity or is a congenital anomaly/birth defect. The investigator assessed each AE as either related or not related to study treatment. (NCT01429051)
Timeframe: 12 weeks
| Intervention | participants (Number) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Any AE | Any AE reported as related to treatment | Non-serious adverse events | Serious adverse events | Deaths | Severe adverse events | AEs leading to withdrawal | AEs possibly associated with nasal intolerability | AEs with an onset within 30 minutes of first dose | |
| Efficacy Phase | 6 | 4 | 5 | 2 | 1 | 2 | 2 | 0 | 3 |
| Titration Phase | 23 | 14 | 22 | 2 | 2 | 2 | 2 | 2 | 11 |
| Tolerability Phase | 22 | 6 | 17 | 8 | 5 | 7 | 3 | 6 | 5 |
Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit
Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Placebo | 53.5 |
| Modafinil | 61.0 |
Postanesthesia Quality Recovery Scale Score
Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -5.67 |
| Modafinil | -8.91 |
Assessment Of Adherence Of The SSEC System To Skin
The adhesion of each SSEC was evaluated immediately prior to removal at each 24-hour time point, or at early withdrawal. Adhesion was recorded using the following classification: System adhered to at least 90% of the application area with no edges unattached; System adhered between 75% and 89%; System was <75% adhered and not taped; System was secured with tape. The number of SSEC systems for all time points in each category is presented. Because of the descriptive nature of this study, no formal statistical hypothesis testing was performed. (NCT02395653)
Timeframe: Immediately prior to removal at each 24-hour time point, or at early withdrawal, for up to 3 consecutive days (up to 72 hours)
| Intervention | SSEC systems (Number) | ||||
|---|---|---|---|---|---|
| ≥90% of area with no edges unattached | 75% to 89% | <75% adhered and not taped | System was secured with tape | Not assessed | |
| SSEC Fentanyl | 97 | 6 | 3 | 1 | 0 |
Assessment Of Participant's Ability To Use The SSEC
Investigator's assessment of participant's ability to use the SSEC system safely and effectively. The assessment consisted of a 4-level categorical evaluation (poor, fair, good, and excellent). Because of the descriptive nature of this study, no formal statistical hypothesis testing was performed. (NCT02395653)
Timeframe: Completed at the time of the participant's termination of study treatment (up to 72 hours after study drug administration)
| Intervention | participants (Number) | ||||
|---|---|---|---|---|---|
| Poor | Fair | Good | Excellent | Missing | |
| SSEC Fentanyl | 1 | 2 | 10 | 48 | 0 |
Change From Baseline To 1 Hour And 24 Hours In Skin Irritation Score After SSEC Removal
Skin irritation at the SSEC application site was to be assessed immediately prior to placement of the study system and at 1 and 24 hours after removal of each study system. The application site was to be scored using the following scale: 0=No evidence of irritation; 1=Minimal erythema, barely perceptible; 2=Definite erythema, readily visible, minimal edema, or minimal papular response; 3=Erythema and papules; 4=Definite edema; 5=Erythema, edema, and papules; 6=Vesicular eruption; 7=Strong reaction spreading beyond the application site. (NCT02395653)
Timeframe: Baseline, 1 hour and 24 hours after SSEC removal.
| Intervention | units on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| System 1, Hour 1 | System 1, Hour 24 | System 2, Hour 1 | System 2, Hour 24 | System 3, Hour 1 | System 3, Hour 24 | |
| SSEC Fentanyl | 1.1 | 1.8 | 1.0 | 1.6 | 1.0 | 0.8 |
Number Of Participants To Experience Clinically Relevant Respiratory Depression (CRRD)
Respiratory function and occurrence of CRRD was defined as simultaneous occurrence of bradypnoea (respiratory rate <10 breaths per minute for participants 9-15 years of age and sustained for 1 minute, or <8 breaths per minute for participants 16-17 years of age), with excessive sedation (that is, the participant is not easily aroused). (NCT02395653)
Timeframe: From the time of application of the first system through 7 days following end of study drug administration.
| Intervention | participants (Number) | ||
|---|---|---|---|
| Bradypnoea | Excessive Sedation | Simultaneous Bradypnoea and Excessive Sedation | |
| SSEC Fentanyl | 0 | 0 | 0 |
Reviews
7 reviews available for fentanyl and Nausea
| Article | Year |
|---|---|
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp | 2023 |
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp | 2023 |
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp | 2023 |
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp | 2023 |
Fentanyl Buccal Soluble Film: A Review in Breakthrough Cancer Pain.
Topics: Administration, Buccal; Analgesics, Opioid; Breakthrough Pain; Disease Management; Fentanyl; Humans; | 2016 |
Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain.
Topics: Administration, Oral; Analgesics, Opioid; Buprenorphine; Chronic Pain; Constipation; Fentanyl; Human | 2012 |
The safety and efficacy of fentanyl iontophoretic transdermal system compared with morphine intravenous patient-controlled analgesia for postoperative pain management: an analysis of pooled data from three randomized, active-controlled clinical studies.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Female; Fentanyl; Fever; Humans; Iontophore | 2007 |
[Combined subarachnoid-epidural technique for obstetric analgesia].
Topics: Adjuvants, Anesthesia; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, | 2000 |
Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control.
Topics: Absorption; Administration, Cutaneous; Analgesia; Analgesics, Opioid; Digestive System; Drug Interac | 2001 |
Drug therapy: analgetic drugs--the potent analgetics.
Topics: Analgesics; Blood Circulation; Fentanyl; Humans; Intestines; Levallorphan; Meperidine; Methadone; Me | 1972 |
Trials
84 trials available for fentanyl and Nausea
| Article | Year |
|---|---|
Effect of additional equipotent fentanyl or sufentanil administration on recovery profiles during propofol-remifentanil-based anaesthesia in patients undergoing gynaecologic laparoscopic surgery: a randomized clinical trial.
Topics: Anesthesia; Delirium; Dizziness; Female; Fentanyl; Humans; Laparoscopy; Nausea; Propofol; Remifentan | 2022 |
Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial.
Topics: Dilatation; Double-Blind Method; Female; Fentanyl; Gabapentin; Humans; Midazolam; Nausea; Pain; Pain | 2023 |
Comparison of the Efficacies of Three Different Intrathecal Doses of Morphine in Achieving Postcesarean Delivery Analgesia.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Cesarean Section; Double-Blind Method; Female; Fe | 2023 |
Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a single ascending dose study in opioid-naïve healthy volunteers.
Topics: Administration, Intravenous; Administration, Sublingual; Adult; Analgesics, Opioid; Female; Fentanyl | 2017 |
The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics, | 2014 |
Comparison of intrathecal bupivacaine, levobupivacaine for cesarean section.
Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Section; Double-Blind Method; F | 2014 |
Efficacy and tolerability of intranasal fentanyl spray in cancer patients with breakthrough pain.
Topics: Adult; Aged; Analgesics, Opioid; Breakthrough Pain; Cross-Over Studies; Double-Blind Method; Female; | 2015 |
Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opi | 2016 |
Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opi | 2016 |
Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opi | 2016 |
Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opi | 2016 |
Comparison of an Intraoperative Infusion of Dexmedetomidine, Fentanyl, and Remifentanil on Perioperative Hemodynamics, Sedation Quality, and Postoperative Pain Control.
Topics: Adolescent; Adult; Analgesics, Opioid; Blood Pressure; Dexmedetomidine; Double-Blind Method; Female; | 2016 |
Comparison of ropivacaine with and without fentanyl vs bupivacaine with fentanyl for postoperative epidural analgesia in bilateral total knee replacement surgery.
Topics: Aged; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, L | 2017 |
Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery.
Topics: Adult; Ambulatory Surgical Procedures; Female; Fentanyl; Humans; Male; Methyl Ethers; Nausea; Pain; | 2008 |
Gastrointestinal symptoms under opioid therapy: a prospective comparison of oral sustained-release hydromorphone, transdermal fentanyl, and transdermal buprenorphine.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Antiemetics; Buprenor | 2009 |
Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Analgesics, Opioid; Antineoplastic Combined Chem | 2008 |
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha | 2010 |
Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study.
Topics: Administration, Sublingual; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cross-Ov | 2010 |
[Effects of preincisional epidural administration of lidocaine and fentanyl on postoperative pain management following hysterectomy].
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Drug Therapy, Combination; | 2002 |
A comparison of anaesthetic techniques for shock wave lithotripsy: the use of a remifentanil infusion alone compared to intermittent fentanyl boluses combined with a low dose propofol infusion.
Topics: Adult; Ambulatory Care; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Combined; Anesthet | 2002 |
[The effect of intrathecal fentanyl added to hyperbaric bupivacaine for caesarean section].
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Endotracheal; Anesthesia, Obstetrical; Anesthesia, Spinal; | 2003 |
[Effect of different methods for postoperative pain management on catecholamine response to abdominal surgery].
Topics: Abdomen; Amides; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; | 2003 |
Efficacy and adverse effects of patient-controlled epidural or intravenous analgesia after major surgery.
Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Intraveno | 2004 |
[Low-dose 0.25% spinal levobupivacaine with epidural extension for cesarean section: comparison with 0.5% hyperbaric bupivacaine].
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local | 2006 |
[Patient-controlled intravenous analgesia with sufentanil and fentanyl after thoracotomy: a comparative study].
Topics: Adult; Analgesia, Patient-Controlled; Esophageal Neoplasms; Female; Fentanyl; Humans; Infusions, Int | 2006 |
Oral sodium citrate increases nausea amongst elective Cesarean delivery patients.
Topics: Administration, Oral; Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Intravenous; | 2006 |
A randomized trial of crystalloid versus colloid solution for prevention of hypotension during spinal or low-dose combined spinal-epidural anesthesia for elective cesarean delivery.
Topics: Adult; Analysis of Variance; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Combined; Bupiva | 2007 |
Intrathecal morphine reduces breakthrough pain during labour epidural analgesia.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Spinal; Anesthet | 2007 |
A randomized clinical trial of oral transmucosal fentanyl citrate versus intravenous morphine sulfate for initial control of pain in children with extremity injuries.
Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Arm Injuries; Child; Female; Fentanyl; Humans; | 2007 |
Bioequivalence following buccal and sublingual placement of fentanyl buccal tablet 400 microg in healthy subjects.
Topics: Administration, Buccal; Administration, Sublingual; Adult; Analgesics, Opioid; Area Under Curve; Chr | 2008 |
On-demand analgesia. A double-blind comparison of on-demand intravenous fentanyl with regular intramuscular morphine.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Fentanyl; Humans; Injections, Intramuscular; I | 1983 |
[The influence of the premedication on subjective postanaesthetic complaints in out-patients (author's transl)].
Topics: Ambulatory Care; Atropine; Droperidol; Fentanyl; Humans; Nausea; Pentazocine; Preanesthetic Medicati | 1980 |
Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Anesthesia, Intravenous; Anesthetics, Inhalation; An | 1995 |
Transdermal fentanyl in combination with initial intravenous dose titration by patient-controlled analgesia.
Topics: Administration, Cutaneous; Analgesia, Patient-Controlled; Analgesics; Constipation; Dose-Response Re | 1995 |
The introduction of patient-controlled analgesia into an isolated rural hospital.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Feasibility Studies; Fentanyl; Hospit | 1995 |
Oral transmucosal fentanyl citrate premedication in patients undergoing outpatient dermatologic procedures.
Topics: Administration, Oral; Adult; Aged; Ambulatory Surgical Procedures; Anti-Anxiety Agents; Anxiety; Blo | 1994 |
Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Droperidol; Ear, | 1995 |
Patient-controlled analgesia following caesarean section under general anaesthesia: a comparison of fentanyl with morphine.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthesia, General; Anesthesia, Obste | 1995 |
Transdermal fentanyl in uncontrolled cancer pain: titration on a day-to-day basis as a procedure for safe and effective dose finding--a pilot study in 20 patients.
Topics: Administration, Cutaneous; Administration, Oral; Fentanyl; Gastrointestinal Motility; Humans; Morphi | 1994 |
Ketorolac versus fentanyl for gynaecological day-case surgery.
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Female; Fentanyl; Genital Diseases, Female; Human | 1993 |
Posture and the spread of hyperbaric bupivacaine in parturients using the combined spinal epidural technique.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia, Epidural; Anesthesia, Obstetrical; A | 1993 |
Prophylactic paracetamol for analgesia after vaginal termination of pregnancy.
Topics: Abortion, Induced; Acetaminophen; Ambulatory Surgical Procedures; Analgesia; Analgesics; Anesthesia, | 1993 |
Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy.
Topics: Acetaminophen; Adult; Ambulatory Care; Diclofenac; Double-Blind Method; Female; Fentanyl; Humans; In | 1993 |
[Laparoscopic cholecystectomy: evaluation of intraoperative complications with respect to 2 different kinds of anesthesia].
Topics: Adult; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous; Cholecystectomy, Laparoscopic; | 1995 |
Incidence of nausea and vomiting in outpatients undergoing general anesthesia in relation to selection of intraoperative opioid.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alfentanil; Ambulatory Surgical Procedures; Analgesics, | 1996 |
Epidural morphine vs hydromorphone in post-caesarean section patients.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Epidural; Anesth | 1996 |
Comparison of diclofenac and tenoxicam for postoperative analgesia with and without fentanyl in children undergoing adenotonsillectomy or tonsillectomy.
Topics: Adenoidectomy; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Blood Loss, Surgical; Ch | 1996 |
The safety and efficacy of oral transmucosal fentanyl citrate for preoperative sedation in young children.
Topics: Administration, Oral; Analgesics, Opioid; Anesthesia Recovery Period; Anxiety; Anxiety, Separation; | 1996 |
A comparison: the efficacy of sevoflurane-nitrous oxide or propofol-nitrous oxide for the induction and maintenance of general anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Inhalation; An | 1996 |
Evaluation of morphine versus fentanyl for postoperative analgesia after ambulatory surgical procedures.
Topics: Adult; Aged; Ambulatory Care; Female; Fentanyl; Humans; Male; Middle Aged; Morphine; Nausea; Palliat | 1997 |
Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol.
Topics: Acetaminophen; Administration, Rectal; Analgesia; Analgesics; Anesthesia Recovery Period; Child; Chi | 1997 |
Transdermal fentanyl system plus im ketorolac for the treatment of postoperative pain.
Topics: Administration, Cutaneous; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 1997 |
Midazolam premedication increases sedation but does not prolong discharge times after brief outpatient general anesthesia for laparoscopic tubal sterilization.
Topics: Adult; Age Factors; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; | 1997 |
A randomized, double-blind, dose-response comparison of epidural fentanyl versus sufentanil analgesia after cesarean section.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Epidural; Anesth | 1997 |
Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting.
Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Antiemet | 1997 |
[Total intravenous anesthesia with propofol and fentanyl for laparoscopic cholecystectomy].
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Inhalatio | 1997 |
Postoperative nausea and vomiting. A retrospective analysis in patients undergoing elective craniotomy.
Topics: Adolescent; Adult; Age Factors; Aged; Analysis of Variance; Anesthesia; Craniotomy; Female; Fentanyl | 1997 |
Epidural infusion of bupivacaine 0.0625% plus fentanyl 3.3 micrograms/ml provides better postoperative analgesia than patient-controlled analgesia with intravenous morphine after gynaecological laparotomy.
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Bupivaca | 1997 |
Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy.
Topics: Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthetics, D | 1998 |
[A comparison of the incidence of postoperative nausea and vomiting after propofol-fentanyl anesthesia and that after nitrous oxide-isoflurane anesthesia].
Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Inhalati | 1998 |
Therapeutic suggestions given during neurolept-anaesthesia decrease post-operative nausea and vomiting.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Antiemetics; Antipsychotic A | 1998 |
Antiemetic activity of propofol after sevoflurane and desflurane anesthesia for outpatient laparoscopic cholecystectomy.
Topics: Adult; Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation; Antiemetics; Cholecystectom | 1998 |
[Our negative experience with meperidine for the prevention of coughing during cataract surgery].
Topics: Antitussive Agents; Cataract Extraction; Cough; Double-Blind Method; Fentanyl; Humans; Intraocular P | 1999 |
Intra-subject variability in post-operative patient-controlled analgesia (PCA): is the patient equally satisfied with morphine, pethidine and fentanyl?
Topics: Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Fentanyl; Humans; Meperidi | 1999 |
Combined spinal epidural for labour analgesia--duration, efficacy and side effects of adding sufentanil or fentanyl to bupivacaine intrathecally vs plain bupivacaine.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Female; Fentany | 1999 |
Pain relief following day case laparoscopic tubal ligation with intra-peritoneal ropivacaine: a randomised double blind control study.
Topics: Adult; Ambulatory Surgical Procedures; Amides; Analgesics, Opioid; Anesthetics, Local; Double-Blind | 2000 |
[Comparison of ropivacaine and bupivacaine for epidural analgesia during labor].
Topics: Adolescent; Adult; Amides; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Apgar Sc | 2001 |
[The efficacy and safety of continuous epidural analgesia versus intradural-epidural analgesia during labor].
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia Recovery Period; Bupivacaine; Cesarea | 2001 |
The antagonist effect of naloxone hydrochloride after neuroleptanaesthesia during neurosurgery.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Blood Pressure; Clinical Trials as Topic; Dose-Respons | 1976 |
Double blind comparison of fentanyl and sulfentanil in anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Blood Pressure; Clinical Trials as Topic; Double-Blind | 1976 |
[Caudal block in children: analgesia and respiratory effect of the combination bupivacaine-fentanyl].
Topics: Anesthesia, Caudal; Bupivacaine; Child; Child, Preschool; Drug Combinations; Fentanyl; Humans; Nause | 1992 |
The incidence of postoperative nausea and vomiting: a retrospective comparison of alfentanil versus sufentanil.
Topics: Adolescent; Adult; Age Factors; Alfentanil; Anesthetics; Female; Fentanyl; Humans; Incidence; Male; | 1992 |
Does epidural fentanyl decrease the efficacy of epidural morphine after cesarean delivery?
Topics: Adult; Anesthesia, Obstetrical; Cesarean Section; Female; Fentanyl; Humans; Injections, Epidural; In | 1992 |
Side effects during continuous epidural infusion of morphine and fentanyl.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Carbon Dioxide; Female; Fentanyl; Hip Prosthesi | 1992 |
Pain following thoracotomy. A randomised, double-blind comparison of lumbar versus thoracic epidural fentanyl.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Double-Blind Method; Female; Fentan | 1991 |
Opioid supplementation to propofol anaesthesia for outpatient abortion: a comparison between alfentanil, fentanyl and placebo.
Topics: Abortion, Induced; Adolescent; Adult; Alfentanil; Anesthesia Recovery Period; Anesthesia, Intravenou | 1991 |
Ibuprofen provides longer lasting analgesia than fentanyl after laparoscopic surgery.
Topics: Administration, Oral; Double-Blind Method; Female; Fentanyl; Humans; Ibuprofen; Injections, Intraven | 1991 |
Total intravenous anaesthesia with propofol or etomidate.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Blood Pressure; Carbon Dioxide; Consciou | 1991 |
A comparison of recovery in outpatients receiving fentanyl versus those receiving butorphanol.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Butorphanol; Dizziness; Double-Blind Met | 1989 |
A comparison of clinical and psychological effects of fentanyl and nalbuphine in ambulatory gynecologic patients.
Topics: Ambulatory Care; Anxiety; Clinical Trials as Topic; Double-Blind Method; Dreams; Female; Fentanyl; H | 1987 |
[Complaints in the postoperative phase related to anesthetics].
Topics: Adolescent; Adult; Alfentanil; Analgesics; Anesthesia, Inhalation; Clinical Trials as Topic; Enflura | 1988 |
Isoflurane v fentanyl for outpatient laparoscopy.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Anesthetics; Drug Evaluation; Female; Fentanyl; Humans; | 1985 |
Nausea and vomiting after general anaesthesia with isoflurane, enflurane or fentanyl in combination with nitrous oxide and oxygen.
Topics: Adult; Anesthesia, Inhalation; Enflurane; Female; Fentanyl; Humans; Hysterectomy; Isoflurane; Middle | 1988 |
[Blood loss and nausea during legal abortion].
Topics: Abortion, Legal; Adolescent; Adult; Anesthesia, Intravenous; Blood Volume; Female; Fentanyl; Humans; | 1985 |
Etomidate versus thiopental for induction of anesthesia.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anesthesia, General; Anesthesia, Inhalation; Anesthes | 1985 |
Thalamonal as a pre-operative sedative.
Topics: Analysis of Variance; Benperidol; Blood Pressure; Clinical Trials as Topic; Drug Synergism; Female; | 1968 |
Studies of drugs given before anaesthesia. 18. The synthetic opiates.
Topics: Analgesics; Clinical Trials as Topic; Dextromoramide; Female; Fentanyl; Humans; Hypotension; Levorph | 1969 |
Other Studies
38 other studies available for fentanyl and Nausea
| Article | Year |
|---|---|
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea; | 2023 |
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea; | 2023 |
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea; | 2023 |
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea; | 2023 |
Prevalence of opioid-induced adverse events across opioids commonly used for analgesic treatment in Japan: a multicenter prospective longitudinal study.
Topics: Analgesics, Opioid; Cancer Pain; Constipation; Delirium; Fentanyl; Humans; Hydromorphone; Japan; Lon | 2023 |
Strong opioids and non-cancer chronic pain in Catalonia. An analysis of the family physicians prescription patterns.
Topics: Analgesics, Opioid; Benzodiazepines; Chronic Pain; Female; Fentanyl; Health Care Surveys; Humans; La | 2020 |
Comparison of the Effects of Sufentanil and Fentanyl in Intravenous Patient-Controlled Analgesia after Pediatric Moyamoya Surgery: A Retrospective Study.
Topics: Administration, Intravenous; Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Child; C | 2020 |
Quality of labour neuraxial analgesia and maternal satisfaction at a tertiary care teaching hospital: a prospective observational study.
Topics: Adjuvants, Anesthesia; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Contro | 2013 |
Lessons learned from hospice care.
Topics: Aged; Aged, 80 and over; Amitriptyline; Analgesics, Opioid; Drug Monitoring; Fentanyl; Health Servic | 2013 |
Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Breakthrough Pain; Constipation; Female; Fentanyl; | 2014 |
[Side Effects of Continuous Fentanyl Infusion for Postoperative Pain Relief in Children].
Topics: Adolescent; Anesthetics, Intravenous; Child; Child, Preschool; Fentanyl; Humans; Infant; Nausea; Pai | 2015 |
Fentanyl transdermal matrix patch (Durotep MT patch; Durogesic DTrans; Durogesic SMAT): in adults with cancer-related pain.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Area Under Curve; Clinical Trials, Phase II as | 2008 |
Differential response to IV carfentanil in chronic cocaine users and healthy controls.
Topics: Adult; Analgesics, Opioid; Brain; Cocaine-Related Disorders; Dizziness; Female; Fentanyl; Half-Life; | 2012 |
Retrospective evaluation of intravenous fentanyl patient-controlled analgesia during labor.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthesia, Intravenous; Apgar Score; | 2012 |
Efficacy and safety of intraoperative intravenous methadone during general anaesthesia for caesarean delivery: a retrospective case-control study.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Genera | 2013 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
Practical oral sedation in dentistry. Part II--Clinical application of various oral sedatives and discussion.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, Dental; Child; Child, | 2006 |
[Feasibility to treat pediatric cancer pain with analgesics for adults and their efficacy].
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Co | 2007 |
[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine].
Topics: Acetaminophen; Anesthetics, Intravenous; Aspirin; Chlorpheniramine; Cholecystectomy, Laparoscopic; D | 2007 |
Ventilatory and mental effects of alfentanil and fentanyl.
Topics: Adult; Alfentanil; Analgesics, Opioid; Depression, Chemical; Double-Blind Method; Female; Fentanyl; | 1984 |
Continuous infusion of alfentanil.
Topics: Adult; Alfentanil; Anesthesia; Blood Pressure; Domperidone; Droperidol; Female; Fentanyl; Heart Rate | 1982 |
Enflurane suppression of complex ventricular dysrhythmias.
Topics: Anesthesia; Arrhythmias, Cardiac; Enflurane; Fentanyl; Heart Ventricles; Humans; Male; Middle Aged; | 1982 |
[Comparison of buprenorphine and fentanyl for postoperative pain relief by continuous epidural infusion].
Topics: Abdomen; Aged; Buprenorphine; Dizziness; Female; Fentanyl; Humans; Injections, Epidural; Male; Middl | 1993 |
Intravenous ketamine or fentanyl prolongs postoperative analgesia after intrathecal neostigmine.
Topics: Analgesia; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Dissociative; Anesthetics, Intraveno | 1996 |
Nausea and vomiting in patients undergoing radiofrequency catheter ablation.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Intravenous; Antiemetics; Cath | 1997 |
Severe hyponatremia after transsphenoidal surgery for pituitary adenomas.
Topics: Adenoma; Adolescent; Adult; Aged; Anesthetics, Intravenous; Female; Fentanyl; Headache; Humans; Hypo | 1998 |
Opioid substitution to reduce adverse effects in cancer pain management.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hospice Care; Humans; Male; Medical A | 1999 |
Neostigmine as the fourth spinal component for labor analgesia?
Topics: Analgesia, Obstetrical; Analgesics; Bupivacaine; Clonidine; Drug Compounding; Drug Therapy, Combinat | 2000 |
[High doses of fentanyl as the sole anaesthetic agent and naloxone as its antagonist (author's transl)].
Topics: Adolescent; Adult; Aged; Analgesia; Autonomic Nervous System; Child; Child, Preschool; Female; Fenta | 1975 |
Laparoscopic cholecystectomy: the anaesthetist's point of view.
Topics: Age Factors; Anesthesia; Anesthesia Recovery Period; Anesthesia, Intravenous; Antiemetics; Cholecyst | 1992 |
Is fentanyl effective for postoperative analgesia in day-surgery?
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesia; Anesthesia | 1992 |
Postoperative analgesia with epidural fentanyl.
Topics: Analgesia, Epidural; Drug Eruptions; Fentanyl; Humans; Nausea; Pain, Postoperative; Retrospective St | 1991 |
Vertigo after epidural morphine.
Topics: Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Female; Fentanyl; Humans; | 1990 |
Comparison of alfentanil with fentanyl for outpatient anesthesia.
Topics: Adult; Alfentanil; Ambulatory Surgical Procedures; Analgesia; Anesthesia; Fentanyl; Humans; Nausea; | 1986 |
Administration of metoclopramide for prevention of nausea and vomiting during epidural anesthesia for elective cesarean section.
Topics: Anesthesia, Epidural; Cesarean Section; Female; Fentanyl; Gestational Age; Humans; Metoclopramide; M | 1987 |
Use of fentanyl markedly increases nausea and vomiting in gynecological short stay patients.
Topics: Ambulatory Care; Female; Fentanyl; Genital Diseases, Female; Humans; Nausea; Vomiting | 1986 |
Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion.
Topics: Adult; Aged; Brain Neoplasms; Carmustine; Carotid Arteries; Diazepam; Droperidol; Drug Therapy, Comb | 1986 |
[A clinical comparison between 3 varieties of neuroleptic anesthesia].
Topics: Anesthesia, Intravenous; Benperidol; Blood Pressure; Diazepam; Female; Fentanyl; Humans; Hydroxyzine | 1973 |
Use of droperidol-fentanyl sedation for cardiac catheterization in children.
Topics: Adolescent; Bradycardia; Cardiac Catheterization; Cardiac Volume; Child; Child, Preschool; Cognition | 1974 |
Neuroleptanalgesia: a new concept in premedication.
Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Anesthesia, Intravenous; Benperidol; Child; Dental Serv | 1971 |
A comparison of neuroleptanesthesia and halothane in neurosurgery.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Blood Pressure; Child; Consciousness; Female; Fenta | 1970 |