Page last updated: 2024-10-27

fentanyl and Nausea

fentanyl has been researched along with Nausea in 129 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Research Excerpts

ExcerptRelevanceReference
"The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain."9.69Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023)
"The aims of this study were to explore the efficacy of intranasal fentanyl spray* (INFS) 400 μg to evaluate 12-week tolerability of the nasal mucosa and to explore safety data for all dose strengths of INFS in patients with cancer-related breakthrough pain (BTP)."9.20Efficacy and tolerability of intranasal fentanyl spray in cancer patients with breakthrough pain. ( Eeg, M; Jaatun, E; Kaasa, S; Kvitberg, M; Popper, L; Thronæs, M, 2015)
"In this study we evaluated the efficacy and tolerability of sublingual fentanyl (SLF) for breakthrough pain (BTP) in adult opioid-tolerant cancer patients."9.14Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study. ( Derrick, R; Frank-Lissbrant, I; Howell, J; Kälkner, KM; Lennernäs, B; Lennernäs, H, 2010)
"Omission of fentanyl did not reduce the overall incidence of postoperative nausea and vomiting, but did reduce the incidence of vomiting and/or moderate to severe nausea prior to discharge from 20% and 17% with fentanyl and fentanyl-dexamethasone, respectively, to 5% (P = 0."9.13Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery. ( Bridgman, S; Smith, I; Walley, G, 2008)
"We investigated the efficacy and safety of transdermal fentanyl for severe mucositis pain caused by chemotherapy."9.13Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy. ( Cai, Q; Guo, Y; Huang, H; Li, Y; Lin, X; Sun, X; Xia, Z, 2008)
"The use of OTFC can provide improved pain control when compared with IV morphine."9.12A randomized clinical trial of oral transmucosal fentanyl citrate versus intravenous morphine sulfate for initial control of pain in children with extremity injuries. ( Christopher, NC; Kennedy, CS; Mahar, PJ; Rana, JA, 2007)
" This difference was still significant when controlling for age, body weight, history of motion sickness, previous PONV episodes, duration of anesthesia, and intraoperative fentanyl consumption using a logistic model."9.08Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting. ( Finco, G; Gottin, L; Grosso, S; Ischia, S; Mosaner, W; Pinaroli, AM; Polati, E; Verlato, G, 1997)
"A prospective, comparative, randomized study to assess rectal acetaminophen (n = 45) to intravenous fentanyl-droperidol (n = 45) to resolve recovery profile, emesis rate, and adequacy of analgesia in a pediatric strabismus repair population was performed, with standardization of the anesthetic technique."9.08Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol. ( Cruz, OA; Krock, JL; Padda, GS, 1997)
"We compared the incidence of postoperative nausea and vomiting after total intravenous propofol-fentanyl anesthesia (TIVA group) and that after thiamylal-nitrous oxide-isoflurane anesthesia (GOI group) in 60 ASA physical I and II patients for elective abdominal simple total hysterectomy."9.08[A comparison of the incidence of postoperative nausea and vomiting after propofol-fentanyl anesthesia and that after nitrous oxide-isoflurane anesthesia]. ( Asada, A; Koh, H; Koyama, S; Noda, K; Tagami, N, 1998)
"At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy."9.07Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993)
"All communications on the use of transdermal fentanyl as well as the recommendations of the manufacturer include the direction that patients should be titrated with a short-acting narcotic to control their cancer pain before they are converted to a fentanyl transdermal therapeutic system (TTS)."9.07Transdermal fentanyl in uncontrolled cancer pain: titration on a day-to-day basis as a procedure for safe and effective dose finding--a pilot study in 20 patients. ( Korte, W; Morant, R, 1994)
"The findings indicate comparability of transdermal buprenorphine and transdermal fentanyl for pain measures with significantly fewer adverse events (nausea and treatment discontinuation due to adverse events) caused by transdermal buprenorphine."8.88Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain. ( Aune, D; Hernandez, AV; Kleijnen, J; Misso, K; Riemsma, R; Truyers, C; Wolff, RF, 2012)
"Transdermal fentanyl is a useful opioid-agonist for the treatment of moderate to severe chronic cancer pain."8.81Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control. ( Muijsers, RB; Wagstaff, AJ, 2001)
"The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement."7.74[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine]. ( Abe, F; Furuya, A; Nagamine, N; Nonaka, A; Suzuki, S, 2007)
"The fentanyl transdermal matrix patch is approved in Japan for the management of moderate to severe cancer-related pain in adults."7.74Fentanyl transdermal matrix patch (Durotep MT patch; Durogesic DTrans; Durogesic SMAT): in adults with cancer-related pain. ( Hoy, SM; Keating, GM, 2008)
"A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas."7.67Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986)
"One-hundred and eighty patients undergoing elective abdominal hysterectomy were anaesthetized in random order with isoflurane, enflurane or fentanyl in combination with nitrous oxide and oxygen."6.66Nausea and vomiting after general anaesthesia with isoflurane, enflurane or fentanyl in combination with nitrous oxide and oxygen. ( Erkola, O; Hovorka, J; Korttila, K, 1988)
"The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain."5.69Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023)
" After thyroidectomy, we evaluated postoperative pain, nausea, fentanyl consumption, frequency of pushing the button (FPB) for patient-controlled analgesia (PCA), High-sensitivity C-reactive protein (hs-CRP) in serum, and patient satisfaction scores regarding the recovery process."5.22Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. ( Ahn, EJ; Baek, CW; Choi, GJ; Jung, YH; Kang, H; Kim, JY; Oh, JI, 2016)
"The aims of this study were to explore the efficacy of intranasal fentanyl spray* (INFS) 400 μg to evaluate 12-week tolerability of the nasal mucosa and to explore safety data for all dose strengths of INFS in patients with cancer-related breakthrough pain (BTP)."5.20Efficacy and tolerability of intranasal fentanyl spray in cancer patients with breakthrough pain. ( Eeg, M; Jaatun, E; Kaasa, S; Kvitberg, M; Popper, L; Thronæs, M, 2015)
" Nausea was significantly more common in the fentanyl group compared with both other groups."5.19The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study. ( Choi, DK; Choi, IC; Kim, K; Kim, WJ; Lee, YK; Sim, JY, 2014)
"The purpose of this trial was to evaluate the effect of long-term treatment with oral sustained-release hydromorphone, transdermal fentanyl, and transdermal buprenorphine on nausea, emesis and constipation."5.14Gastrointestinal symptoms under opioid therapy: a prospective comparison of oral sustained-release hydromorphone, transdermal fentanyl, and transdermal buprenorphine. ( Kloecker, N; Mueller, M; Nadstawek, J; Schaefer, N; Schenk, M; Schroeck, A; Standop, J; Wirz, S; Wittmann, M, 2009)
"In this study we evaluated the efficacy and tolerability of sublingual fentanyl (SLF) for breakthrough pain (BTP) in adult opioid-tolerant cancer patients."5.14Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study. ( Derrick, R; Frank-Lissbrant, I; Howell, J; Kälkner, KM; Lennernäs, B; Lennernäs, H, 2010)
"We investigated the efficacy and safety of transdermal fentanyl for severe mucositis pain caused by chemotherapy."5.13Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy. ( Cai, Q; Guo, Y; Huang, H; Li, Y; Lin, X; Sun, X; Xia, Z, 2008)
"Omission of fentanyl did not reduce the overall incidence of postoperative nausea and vomiting, but did reduce the incidence of vomiting and/or moderate to severe nausea prior to discharge from 20% and 17% with fentanyl and fentanyl-dexamethasone, respectively, to 5% (P = 0."5.13Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery. ( Bridgman, S; Smith, I; Walley, G, 2008)
"At all recorded intervals, the average degree of nausea was greater in the sodium citrate group compared to the famotidine group."5.12Oral sodium citrate increases nausea amongst elective Cesarean delivery patients. ( Abramovitz, S; Comerford, M; DiMaria, L; Gadalla, F; Kiselev, M; Kjaer, K; Kondilis, L; Leighton, BL; Samuels, J, 2006)
"The addition of small dose of morphine to the spinal component of the CSE technique improved the effectiveness of epidural labour analgesia and reduced the need for pain medications over 24 h, but resulted in a small increase in nausea."5.12Intrathecal morphine reduces breakthrough pain during labour epidural analgesia. ( Hess, PE; Sarge, TW; Snowman, CE; Sundar, S; Vasudevan, A, 2007)
"The use of OTFC can provide improved pain control when compared with IV morphine."5.12A randomized clinical trial of oral transmucosal fentanyl citrate versus intravenous morphine sulfate for initial control of pain in children with extremity injuries. ( Christopher, NC; Kennedy, CS; Mahar, PJ; Rana, JA, 2007)
"PCIA with sufentanil provides better efficacy of analgesia and sedation with lower incidence of nausea and vomiting than with fentanyl in postoperative patients with thoracotomy."5.12[Patient-controlled intravenous analgesia with sufentanil and fentanyl after thoracotomy: a comparative study]. ( Gu, MN; Lin, CS; Lu, G; Ruan, LY, 2006)
"5 mg bupivacaine given intrathecally via combined spinal epidural (CSE) for labour pain relief in the first stage."5.09Combined spinal epidural for labour analgesia--duration, efficacy and side effects of adding sufentanil or fentanyl to bupivacaine intrathecally vs plain bupivacaine. ( Chen, LH; Chong, JL; Lo, WK, 1999)
" We recorded pain as assessed on a visual analog scale, extension of sensory and motor block, maternal hemodynamic constants, number of boluses of bupivacaine used, total doses of bupivacaine and oxytocin, instruments needed for childbirth, and side effects (pruritus, nausea and vomiting)."5.09[The efficacy and safety of continuous epidural analgesia versus intradural-epidural analgesia during labor]. ( Caba, F; Calderón, J; Echevarría, M; Gómez, P; Martínez, A; Rodríguez, R, 2001)
"Propofol-fentanyl seems to be a better anesthetic than isoflurane-fentanyl in reducing the incidence of nausea and vomiting after middle ear surgery."5.08Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery. ( Fowles, S; Jellish, WS; Leonetti, JP; Murdoch, JR, 1995)
"Controversy exists regarding the effectiveness of propofol to prevent postoperative nausea and vomiting."5.08Antiemetic activity of propofol after sevoflurane and desflurane anesthesia for outpatient laparoscopic cholecystectomy. ( Song, D; White, PF; Whitten, CW; Yu, SY; Zarate, E, 1998)
"We compared the incidence of postoperative nausea and vomiting after total intravenous propofol-fentanyl anesthesia (TIVA group) and that after thiamylal-nitrous oxide-isoflurane anesthesia (GOI group) in 60 ASA physical I and II patients for elective abdominal simple total hysterectomy."5.08[A comparison of the incidence of postoperative nausea and vomiting after propofol-fentanyl anesthesia and that after nitrous oxide-isoflurane anesthesia]. ( Asada, A; Koh, H; Koyama, S; Noda, K; Tagami, N, 1998)
"05 mg kg(-1) +droperidol 20 microg kg(-1) was given as prophylaxis for postoperative pain and emesis, respectively."5.08Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy. ( Aasbø, V; Buanes, T; Grøgaard, B; Mjåland, O; Raeder, JC, 1998)
"A prospective, comparative, randomized study to assess rectal acetaminophen (n = 45) to intravenous fentanyl-droperidol (n = 45) to resolve recovery profile, emesis rate, and adequacy of analgesia in a pediatric strabismus repair population was performed, with standardization of the anesthetic technique."5.08Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol. ( Cruz, OA; Krock, JL; Padda, GS, 1997)
" Data extracted from surgery and the initial 48 hours postoperatively included gender, age, supratentorial versus infratentorial craniotomy, type of anesthesia (general versus monitored anesthesia care), intraoperative fentanyl dose, duration of anesthesia, antiemetic administration intraoperatively and postoperatively, and incidence of postoperative nausea, emesis, and opioid use."5.08Postoperative nausea and vomiting. A retrospective analysis in patients undergoing elective craniotomy. ( Borel, CO; el-Moalem, HE; Fabling, JM; Gan, TJ; Guy, J; Warner, DS, 1997)
" This difference was still significant when controlling for age, body weight, history of motion sickness, previous PONV episodes, duration of anesthesia, and intraoperative fentanyl consumption using a logistic model."5.08Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting. ( Finco, G; Gottin, L; Grosso, S; Ischia, S; Mosaner, W; Pinaroli, AM; Polati, E; Verlato, G, 1997)
"At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy."5.07Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993)
"One hundred and sixty-four patients scheduled for elective termination of pregnancy under general anaesthesia were randomly assigned to receive one of three different supplements to propofol and oxygen in nitrous oxide anaesthesia: 0."5.07Opioid supplementation to propofol anaesthesia for outpatient abortion: a comparison between alfentanil, fentanyl and placebo. ( Andreen, M; Davidson, S; Jakobsson, J; Westgreen, M, 1991)
"Respiratory effects, nausea, somnolence, and pruritus were compared during a 48-hr period of continuous epidural morphine (n = 34) and fentanyl (n = 32) infusion in 66 patients following elective total replacement of the hip or knee joint."5.07Side effects during continuous epidural infusion of morphine and fentanyl. ( Berghausen, EJ; Dumont, SW; Heine, MF; Huang, KC; Schroeder, JA; Tsueda, K; Vogel, RL; White, MJ, 1992)
"All communications on the use of transdermal fentanyl as well as the recommendations of the manufacturer include the direction that patients should be titrated with a short-acting narcotic to control their cancer pain before they are converted to a fentanyl transdermal therapeutic system (TTS)."5.07Transdermal fentanyl in uncontrolled cancer pain: titration on a day-to-day basis as a procedure for safe and effective dose finding--a pilot study in 20 patients. ( Korte, W; Morant, R, 1994)
"In two prospective, randomized studies the frequency of headache, nausea, vomiting, and analgesic requirement during the first postoperative 24 h was observed in order to study differences between the sexes and the inhalation anesthetics halothane, enflurane, isoflurane, or balanced anesthesia with enflurane/alfentanil."5.06[Complaints in the postoperative phase related to anesthetics]. ( Fritz, T; Guggenberger, E; Guggenberger, H; Heuser, D; Warth, H; Wittkowski, KM, 1988)
" (n=54) or the combination droperidol-fentanylatropine (n=123) complain significantly less frequently about nausea and/or vomiting than patients receiving pentazocine-atropine (n=64)."5.05[The influence of the premedication on subjective postanaesthetic complaints in out-patients (author's transl)]. ( Kreienbühl, G, 1980)
" Patients in whom anesthesia was induced with etomidate had a greater incidence of pain on injection and myoclonus and a lesser incidence of apnea than patients in whom anesthesia was induced with thiopental."5.05Etomidate versus thiopental for induction of anesthesia. ( Giese, JL; Nelissen, RH; Pace, NL; Stanley, TH; Stockham, RJ, 1985)
"The findings indicate comparability of transdermal buprenorphine and transdermal fentanyl for pain measures with significantly fewer adverse events (nausea and treatment discontinuation due to adverse events) caused by transdermal buprenorphine."4.88Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain. ( Aune, D; Hernandez, AV; Kleijnen, J; Misso, K; Riemsma, R; Truyers, C; Wolff, RF, 2012)
"Transdermal fentanyl is a useful opioid-agonist for the treatment of moderate to severe chronic cancer pain."4.81Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control. ( Muijsers, RB; Wagstaff, AJ, 2001)
" However, PCA with sufentanil was more frequently discontinued due to nausea or vomiting compared to fentanyl-based PCA."3.96Comparison of the Effects of Sufentanil and Fentanyl in Intravenous Patient-Controlled Analgesia after Pediatric Moyamoya Surgery: A Retrospective Study. ( Jang, YE; Kim, EH; Kim, HS; Kim, JT; Lee, JH; Lim, L, 2020)
"The fentanyl transdermal matrix patch is approved in Japan for the management of moderate to severe cancer-related pain in adults."3.74Fentanyl transdermal matrix patch (Durotep MT patch; Durogesic DTrans; Durogesic SMAT): in adults with cancer-related pain. ( Hoy, SM; Keating, GM, 2008)
"The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement."3.74[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine]. ( Abe, F; Furuya, A; Nagamine, N; Nonaka, A; Suzuki, S, 2007)
"To determine the incidence of nausea and vomiting after radiofrequency catheter ablation, determine factors related to nausea and vomiting, and evaluate the antiemetic efficacy of promethazine given during the procedure."3.69Nausea and vomiting in patients undergoing radiofrequency catheter ablation. ( Funk, M; Nyström, KV; Tyndall, A, 1997)
"A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas."3.67Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986)
"The administration of alfentanil by continuous infusion as supplementation to nitrous oxide for shortlasting anesthesias has been studied in 51 patients."3.66Continuous infusion of alfentanil. ( Booij, LH; Pelgrom, R; Steegers, PA, 1982)
"PCA-fentanyl consumption was significantly higher in Group 1 compared to Group 2 and 3 (P = ."3.30Comparison of the Efficacies of Three Different Intrathecal Doses of Morphine in Achieving Postcesarean Delivery Analgesia. ( Kocamanoğlu, İS; Tamdoğan, İ; Turunç, E, 2023)
"The rates of respiratory depression (1."3.11Effect of additional equipotent fentanyl or sufentanil administration on recovery profiles during propofol-remifentanil-based anaesthesia in patients undergoing gynaecologic laparoscopic surgery: a randomized clinical trial. ( Huang, D; Huang, J; Jian, Q; Li, P; Ma, J; Xie, H; Zeng, W; Zhang, C, 2022)
" Safety assessments, including adverse event (AE) monitoring, occurred from dosing through Day 7."2.84Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a single ascending dose study in opioid-naïve healthy volunteers. ( Koch, C; Nalamachu, S; Oh, DA; Parikh, N; Rauck, R; Singla, N; Vetticaden, S; Yu, J, 2017)
"Modafinil 200 mg was administered to the treatment group patients 1 h before sedation/analgesia."2.75Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010)
"The purpose of this retrospective study was to determine whether epidural fentanyl-bupivacaine patient-controlled analgesia (PCA) was more efficacious and had fewer adverse effects than epidural or intravenous morphine PCA."2.71Efficacy and adverse effects of patient-controlled epidural or intravenous analgesia after major surgery. ( Hu, JS; Liew, C; Lui, PW; Teng, YH; Tsai, SK, 2004)
"This study examined the intra-operative and postoperative characteristics of a remifentanil infusion alone, or intermittent fentanyl bolus admistration combined with a propofol infusion, for the anaesthetic management of patients undergoing shock wave lithotripsy."2.70A comparison of anaesthetic techniques for shock wave lithotripsy: the use of a remifentanil infusion alone compared to intermittent fentanyl boluses combined with a low dose propofol infusion. ( Blanc, I; Brauer, P; Burmeister, MA; Graefen, M; Standl, TG; Wintruff, M, 2002)
"TTS fentanyl was shown to be an effective, safe and simple method for long-term pain relief in cancer patients and presents an interesting novel option in the treatment of cancer pain."2.68Transdermal fentanyl in combination with initial intravenous dose titration by patient-controlled analgesia. ( Lehmann, KA; Zech, DF, 1995)
"Midazolam was associated with impairment of performance on the TDT and DSST after premedication administration and 15 (TDT and DSST) and 30 (DSST) min after postanesthesia care unit (PACU) arrival."2.68Midazolam premedication increases sedation but does not prolong discharge times after brief outpatient general anesthesia for laparoscopic tubal sterilization. ( Hussain, A; Richardson, MG; Wu, CL, 1997)
"Propofol, 2 mg/kg, was administered intravenously for induction of anesthesia and followed by propofol, 50 to 250 micrograms/kg/min, for maintenance anesthesia."2.68Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery. ( Fowles, S; Jellish, WS; Leonetti, JP; Murdoch, JR, 1995)
"Pruritus was more pronounced within the first six hours in Group 1 and at 18 hr in Group 2."2.68Epidural morphine vs hydromorphone in post-caesarean section patients. ( Arellano, R; Carstoniu, J; Halpern, SH; O'Leary, G; Preston, R; Roger, S; Sandler, A, 1996)
"This study was designed to determine and compare the dose-response characteristics, speed of onset, and relative potency of single-dose epidural fentanyl (F) and sufentanil (S) for postoperative pain relief."2.68A randomized, double-blind, dose-response comparison of epidural fentanyl versus sufentanil analgesia after cesarean section. ( Grass, JA; Harris, AP; Michitsch, R; Sakima, NT; Schmidt, R; Zuckerman, RL, 1997)
"Nausea was noted in 61% of the parturients in the lateral group and in 22% (P < 0."2.67Posture and the spread of hyperbaric bupivacaine in parturients using the combined spinal epidural technique. ( Morgan, B; Patel, M; Samsoon, G; Swami, A, 1993)
"Oral transmucosal fentanyl citrate (OTFC) is a novel lozenge dosage form of fentanyl used for premedication."2.67Oral transmucosal fentanyl citrate premedication in patients undergoing outpatient dermatologic procedures. ( Bezzant, JL; Gerwels, JW; Le Maire, L; Pauley, LF; Streisand, JB, 1994)
"Postoperative pain was scored with Hannalah and Broadman's score (0 to 10) 2, 4, 8 and 24 h after the caudal block."2.67[Caudal block in children: analgesia and respiratory effect of the combination bupivacaine-fentanyl]. ( Ecoffey, C; Moine, P, 1992)
"Postoperative pain was reported in 35% of patients, with no significant difference between treated and control patients."2.67Prophylactic paracetamol for analgesia after vaginal termination of pregnancy. ( Ashley, J; Cade, L, 1993)
" The low- and high-dose nalbuphine groups clinically resembled the fentanyl group in terms of dosing frequency and patients' self-ratings of postoperative analgesia."2.66A comparison of clinical and psychological effects of fentanyl and nalbuphine in ambulatory gynecologic patients. ( Earls, F; Garfield, FB; Garfield, JM; Philip, BK; Roaf, E, 1987)
"Isoflurane and fentanyl have been compared as anaesthetic agents for outpatient laparoscopy."2.66Isoflurane v fentanyl for outpatient laparoscopy. ( Dodgson, MS; Rising, S; Steen, PA, 1985)
"One-hundred and eighty patients undergoing elective abdominal hysterectomy were anaesthetized in random order with isoflurane, enflurane or fentanyl in combination with nitrous oxide and oxygen."2.66Nausea and vomiting after general anaesthesia with isoflurane, enflurane or fentanyl in combination with nitrous oxide and oxygen. ( Erkola, O; Hovorka, J; Korttila, K, 1988)
"Fentanyl ITS was equally effective when compared with morphine IV PCA for patient subpopulations (age, surgery type, and BMI)."2.44The safety and efficacy of fentanyl iontophoretic transdermal system compared with morphine intravenous patient-controlled analgesia for postoperative pain management: an analysis of pooled data from three randomized, active-controlled clinical studies. ( Damaraju, CV; Hewitt, DJ; Kershaw, P; Siccardi, M; Viscusi, ER, 2007)
"Uterine fibroid embolization (UFE) procedures performed from 2013 to 2019 were reviewed."1.91Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols. ( Brahler, T; Hastings, G; Howles-Banerji, G; Kotton, M; Price, A; Singer, D; Wrenn, SJ, 2023)
"Although opioids have been shown to be effective for cancer pain, opioid-induced adverse events (AEs) are common."1.91Prevalence of opioid-induced adverse events across opioids commonly used for analgesic treatment in Japan: a multicenter prospective longitudinal study. ( Arakawa, S; Chiu, SW; Hiratsuka, Y; Hirayama, H; Inoue, A; Ishiki, H; Kosugi, K; Kubo, E; Matsuda, Y; Miyashita, M; Morita, T; Natsume, M; Nishijima, K; Ouchi, K; Sato, M; Satomi, E; Shigeno, T; Shimizu, M; Shimoda, M; Shimoi, T; Tagami, K; Yamaguchi, T; Yokomichi, N, 2023)
"7%) reduced benzodiazepines dosage when prescribing potent opioids."1.56Strong opioids and non-cancer chronic pain in Catalonia. An analysis of the family physicians prescription patterns. ( Adriyanov, B; Álvarez Carrera, MA; Dürsteler, C; Perelló Bratescu, A; Riera Nadal, N; Sisó-Almirall, A, 2020)
"Fentanyl was administered at a dose of 0."1.42[Side Effects of Continuous Fentanyl Infusion for Postoperative Pain Relief in Children]. ( Ikejima, N; Kabara, S; Kagawa, T; Sueda, A; Takatsuji, S, 2015)
"IV-PCA provided timely, safe and useful analgesia for patients with severe breakthrough pain and may be useful to help titration of opioids, weaning to oral analgesia and to decide for interventional procedures."1.40Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study. ( Ashmawi, HA; Cascudo, GM; de Santana Neto, J; Guimaraes, GM; Neto, JO; Sousa, AM, 2014)
"Lacking enough knowledge of pediatric cancer pain and pediatric dosage form of analgesics, current treatment of pediatric cancer pain in China is unsatisfactory."1.34[Feasibility to treat pediatric cancer pain with analgesics for adults and their efficacy]. ( Lin, H; Ling, JY; Luo, WB; Sun, XF; Xia, Y; Zhen, ZJ; Zheng, L, 2007)
"The risk of respiratory depression increased with age."1.32Side effects of opioids during short-term administration: effect of age, gender, and race. ( Baumgarten, M; Boston, R; Carr, DB; Cepeda, MS; Farrar, JT; Strom, BL, 2003)
"To assess the effect of opioid substitution (substituting one member of the opioid class for another) on the incidence and severity of adverse effects in palliative care patients who experience unacceptable, refractory adverse effects when taking an opioid drug."1.30Opioid substitution to reduce adverse effects in cancer pain management. ( Ashby, MA; Jackson, KA; Martin, P, 1999)
"Severe hyponatremia has been described after elective surgery with subsequent permanent brain damage."1.30Severe hyponatremia after transsphenoidal surgery for pituitary adenomas. ( Boehnert, M; Buchfelder, M; Fahlbusch, R; Gross, P; Henig, A; Hensen, J, 1998)

Research

Studies (129)

TimeframeStudies, this research(%)All Research%
pre-199026 (20.16)18.7374
1990's50 (38.76)18.2507
2000's27 (20.93)29.6817
2010's18 (13.95)24.3611
2020's8 (6.20)2.80

Authors

AuthorsStudies
Zhang, C1
Huang, D1
Zeng, W1
Ma, J1
Li, P1
Jian, Q1
Huang, J1
Xie, H1
Brant, AR1
Reeves, MF1
Ye, PP1
Scott, RK1
Floyd, S1
Tefera, E1
Lotke, PS1
LA Via, L3
Santonocito, C3
Bartolotta, N3
Lanzafame, B3
Morgana, A3
Continella, C3
Cirica, G3
Astuto, M3
Sanfilippo, F3
Hastings, G2
Brahler, T2
Howles-Banerji, G2
Kotton, M2
Price, A2
Singer, D2
Wrenn, SJ2
Tamdoğan, İ1
Turunç, E1
Kocamanoğlu, İS1
Hiratsuka, Y1
Tagami, K1
Inoue, A1
Sato, M1
Matsuda, Y1
Kosugi, K1
Kubo, E1
Natsume, M1
Ishiki, H1
Arakawa, S1
Shimizu, M1
Yokomichi, N1
Chiu, SW1
Shimoda, M1
Hirayama, H1
Nishijima, K1
Ouchi, K1
Shimoi, T1
Shigeno, T1
Yamaguchi, T1
Miyashita, M1
Morita, T1
Satomi, E1
Perelló Bratescu, A1
Adriyanov, B1
Dürsteler, C1
Sisó-Almirall, A1
Álvarez Carrera, MA1
Riera Nadal, N1
Lim, L1
Jang, YE1
Kim, EH1
Lee, JH1
Kim, JT1
Kim, HS1
Rauck, R1
Oh, DA1
Parikh, N1
Koch, C1
Singla, N1
Yu, J1
Nalamachu, S1
Vetticaden, S1
Clivatti, J1
Siddiqui, N1
Goel, A1
Shaw, M1
Crisan, I1
Carvalho, JC1
Martin, CM1
Sousa, AM1
de Santana Neto, J1
Guimaraes, GM1
Cascudo, GM1
Neto, JO1
Ashmawi, HA1
Kim, K1
Kim, WJ1
Choi, DK1
Lee, YK1
Choi, IC1
Sim, JY1
Sundarathiti, P1
Sangdee, N1
Sangasilpa, I1
Prayoonhong, W1
Papoun, S1
Thronæs, M1
Popper, L1
Eeg, M1
Jaatun, E1
Kvitberg, M1
Kaasa, S1
Kabara, S1
Kagawa, T1
Ikejima, N1
Takatsuji, S1
Sueda, A1
Garnock-Jones, KP1
Choi, GJ1
Kang, H1
Ahn, EJ1
Oh, JI1
Baek, CW1
Jung, YH1
Kim, JY1
Choi, JW1
Joo, JD1
Kim, DW1
In, JH1
Kwon, SY1
Seo, K1
Han, D1
Cheon, GY1
Jung, HS1
Khanna, A1
Saxena, R1
Dutta, A1
Ganguly, N1
Sood, J1
Smith, I1
Walley, G1
Bridgman, S1
Hoy, SM1
Keating, GM1
Wirz, S1
Wittmann, M1
Schenk, M1
Schroeck, A1
Schaefer, N1
Mueller, M1
Standop, J1
Kloecker, N1
Nadstawek, J1
Cai, Q1
Huang, H1
Sun, X1
Xia, Z1
Li, Y1
Lin, X1
Guo, Y1
Galvin, E1
Boesjes, H1
Hol, J1
Ubben, JF1
Klein, J1
Verbrugge, SJ1
Lennernäs, B1
Frank-Lissbrant, I1
Lennernäs, H1
Kälkner, KM1
Derrick, R1
Howell, J1
Minkowski, CP1
Epstein, D1
Frost, JJ1
Gorelick, DA1
Hosokawa, Y1
Morisaki, H1
Nakatsuka, I1
Hashiguchi, S1
Miyakoshi, K1
Tanaka, M1
Yoshimura, Y1
Takeda, J1
Wolff, RF1
Aune, D1
Truyers, C1
Hernandez, AV1
Misso, K1
Riemsma, R1
Kleijnen, J1
Russell, T1
Mitchell, C1
Paech, MJ1
Pavy, T2
Yao, L1
Wang, T1
Yang, B1
Burmeister, MA1
Brauer, P1
Wintruff, M1
Graefen, M1
Blanc, I1
Standl, TG1
Obara, M1
Sawamura, S1
Satoh, Y1
Chinzei, M1
Sekiyama, H1
Tamai, H1
Yamamoto, H1
Hanaoka, K1
Cepeda, MS2
Farrar, JT1
Baumgarten, M1
Boston, R1
Carr, DB2
Strom, BL1
Zeng, L1
Wu, X1
Ma, Q1
Su, Y1
Teng, YH1
Hu, JS1
Tsai, SK1
Liew, C1
Lui, PW1
Vicente, JM1
Guasch, EV1
Bermejo, JM1
Gilsanz, F1
Lin, CS1
Lu, G1
Ruan, LY1
Gu, MN1
Kjaer, K1
Comerford, M1
Kondilis, L1
DiMaria, L1
Abramovitz, S1
Kiselev, M1
Samuels, J1
Gadalla, F1
Leighton, BL1
Lu, DP1
Lu, WI1
Ko, JS1
Kim, CS1
Cho, HS1
Choi, DH1
Vasudevan, A1
Snowman, CE1
Sundar, S1
Sarge, TW1
Hess, PE1
Zhen, ZJ1
Sun, XF1
Xia, Y1
Ling, JY1
Zheng, L1
Luo, WB1
Lin, H1
Mahar, PJ1
Rana, JA1
Kennedy, CS1
Christopher, NC1
Viscusi, ER1
Siccardi, M1
Damaraju, CV1
Hewitt, DJ1
Kershaw, P1
Nonaka, A1
Suzuki, S1
Nagamine, N1
Furuya, A1
Abe, F1
Darwish, M1
Kirby, M1
Jiang, JG1
Tracewell, W1
Robertson, P1
Scamman, FL1
Ghoneim, MM1
Korttila, K3
Welchew, EA1
Steegers, PA1
Booij, LH1
Pelgrom, R1
Smith, M1
Kroll, D1
Breckenridge, J1
Kreienbühl, G1
Jellish, WS2
Leonetti, JP2
Murdoch, JR2
Fowles, S2
Zech, DF1
Lehmann, KA1
Watts, RW1
Fletcher, IA1
Kiroff, GK1
Weber, C1
Owen, H1
Plummer, JL1
Gerwels, JW1
Bezzant, JL1
Le Maire, L1
Pauley, LF1
Streisand, JB1
Howell, PR1
Gambling, DR1
McMorland, G1
Douglas, MJ1
Korte, W1
Morant, R1
Monagle, J1
Wongprasartsuk, P1
Shearer, W1
Patel, M1
Samsoon, G1
Swami, A1
Morgan, B1
Hayashi, H1
Nishiuchi, T1
Tamura, H1
Takeda, K1
Cade, L2
Ashley, J1
Hovorka, J2
Kallela, H1
Delogu, G1
Tomasello, C1
Tellan, G1
Pennacchiotti, ML1
Marandola, M1
Vecchia, P1
Gonzalez, F1
Granados, V1
Cuervo, R1
Halpern, SH1
Arellano, R1
Preston, R1
Carstoniu, J1
O'Leary, G1
Roger, S1
Sandler, A1
Lauretti, GR1
Azevedo, VM1
Mendham, JE1
Mather, SJ1
Epstein, RH1
Mendel, HG1
Witkowski, TA1
Waters, R1
Guarniari, KM1
Marr, AT1
Lessin, JB1
Lien, CA1
Hemmings, HC1
Belmont, MR1
Abalos, A1
Hollmann, C1
Kelly, RE1
Claxton, AR1
McGuire, G1
Chung, F1
Cruise, C1
Padda, GS1
Cruz, OA1
Krock, JL1
Reinhart, DJ1
Goldberg, ME1
Roth, JV1
Dua, R1
Nevo, I1
Klein, KW1
Torjman, M1
Vekeman, D1
Richardson, MG1
Wu, CL1
Hussain, A1
Grass, JA1
Sakima, NT1
Schmidt, R1
Michitsch, R1
Zuckerman, RL1
Harris, AP1
Polati, E1
Verlato, G1
Finco, G1
Mosaner, W1
Grosso, S1
Gottin, L1
Pinaroli, AM1
Ischia, S1
Morimoto, Y1
Matsumoto, S1
Nakamura, M1
Makino, A1
Tamura, T1
Oka, H1
Shimizu, K1
Miyauchi, Y1
Fabling, JM1
Gan, TJ1
Guy, J1
Borel, CO1
el-Moalem, HE1
Warner, DS1
Tsui, SL1
Lee, DK1
Ng, KF1
Chan, TY1
Chan, WS1
Lo, JW1
Tyndall, A1
Nyström, KV1
Funk, M1
Boehnert, M1
Hensen, J1
Henig, A1
Fahlbusch, R1
Gross, P1
Buchfelder, M1
Raeder, JC1
Mjåland, O1
Aasbø, V1
Grøgaard, B1
Buanes, T1
Koyama, S1
Koh, H1
Noda, K1
Tagami, N1
Asada, A1
Eberhart, LH1
Döring, HJ1
Holzrichter, P1
Roscher, R1
Seeling, W1
Song, D1
Whitten, CW1
White, PF2
Yu, SY1
Zarate, E1
Ashby, MA1
Martin, P1
Jackson, KA1
Carrero Cardenal, EJ1
Valero Castell, R1
Roux Carmona, C1
Lapena Bayo, C1
Ortells Ribé, J1
Artigas Rubio, X1
Woodhouse, A1
Ward, EM1
Mather, LE1
Lo, WK1
Chong, JL1
Chen, LH1
Fernández-Guisasola, J1
García del Valle, S1
Gómez-Arnau, JI1
Vercauteren, MP1
Van de Velde, M1
Dreher, JK1
Nemeth, D1
Limb, R1
Sánchez-Conde, P1
Nicolás, J1
Rodríguez, J1
García-Castaño, M1
del Barrio, E1
Muriel, C1
Gómez, P1
Echevarría, M1
Calderón, J1
Caba, F1
Martínez, A1
Rodríguez, R1
Muijsers, RB1
Wagstaff, AJ1
Arnér, S1
Gordon, E1
Van De Walle, J1
Lauwers, P1
Adriaensen, H1
Freye, E1
Rose, DK1
Cohen, MM1
Soutter, DI1
Moine, P1
Ecoffey, C1
Bloomfield, EL1
Vincent, RD1
Chestnut, DH2
Choi, WW2
Ostman, PL1
Bates, JN2
Ross, AW1
White, MJ1
Berghausen, EJ1
Dumont, SW1
Tsueda, K1
Schroeder, JA1
Vogel, RL1
Heine, MF1
Huang, KC1
Coe, A1
Sarginson, R1
Smith, MW1
Donnelly, RJ1
Russell, GN1
Jakobsson, J1
Davidson, S1
Andreen, M1
Westgreen, M1
Rosenblum, M1
Weller, RS1
Conard, PL1
Falvey, EA1
Gross, JB1
Lytle, SA1
Goldsmith, DM1
Neuendorf, TL1
Lowry, ME1
Fruergaard, K1
Jenstrup, M1
Schierbeck, J1
Wiberg-Jørgensen, F1
Goundrey, J1
Wetchler, BV1
Alexander, CD1
Shariff, MS1
Gaudzels, GM1
Garfield, JM1
Garfield, FB1
Philip, BK1
Earls, F1
Roaf, E1
Coe, V1
Shafer, A1
Sung, ML1
Guggenberger, H1
Fritz, T1
Guggenberger, E1
Warth, H1
Wittkowski, KM1
Heuser, D1
Rising, S1
Dodgson, MS1
Steen, PA1
Erkola, O1
Vandewalker, GE1
Owen, CL1
Gaskey, NJ1
Ferriero, L1
Pournaras, L1
Seecof, J1
Klein, DS1
Klein, PW1
Mahaley, MS1
Carcey, J1
Rosencher, N1
Guillaume, F1
Berthet, J1
Giese, JL1
Stockham, RJ1
Stanley, TH1
Pace, NL1
Nelissen, RH1
Vandam, LD1
Bernhoff, A1
Jakt, L1
Graham, TP1
Atwood, GF1
Werner, B1
Norris, W1
Telfer, AB1
Morrison, JD1
Loan, WB1
Dundee, JW1
McDowell, SA1
Brown, SS1
Shamash, R1
Gutman, D1
Birkhan, J1
Knape, H1

Clinical Trials (16)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Gabapentin as an Adjunct for Pain Management During Dilation and Evacuation: A Double-blind Randomized Controlled Trial[NCT03635905]Phase 4130 participants (Actual)Interventional2017-05-26Completed
A Phase 1, Open-label, Randomized, Single Ascending Dose Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fentanyl Sublingual Spray and Fentanyl Citrate Intravenous (IV) in Opioid Naive Subjects[NCT02576353]Phase 150 participants (Actual)Interventional2015-10-31Completed
Adjuvant Continuous Infusion of Nefopam Versus Standard of Care in Mechanically Ventilated Critically Ill Patients: Randomized Double-blind Controlled Study[NCT05071352]Phase 360 participants (Anticipated)Interventional2021-10-01Recruiting
A Dose Titrated Clinical Trial With a Placebo-controlled, Double-blind, Randomised, Cross-over Phase to Demonstrate the Efficacy of 400 μg Intranasal Fentanyl (INFS) Dose Strength, and to Evaluate 12 Weeks Safety and Nasal Tolerability of All Dose Strengt[NCT01429051]Phase 346 participants (Actual)Interventional2011-08-31Completed
Intravenous Lidocaine for Effective Pain Relief After Thyroidectomy: a Prospective, Randomized, Double-blind, Placebo-controlled Study[NCT01608360]Phase 456 participants (Anticipated)Interventional2011-07-31Recruiting
Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs[NCT04741880]Phase 2/Phase 366 participants (Anticipated)Interventional2021-06-17Recruiting
Comparison of the Effect of Intra-articular Administration of 2% Ropivacaine vs. 7.5% Ropivacaine as an Analgesic in the Immediate Postoperative Period of Knee Arthroscopy in Acute Injuries at the ABC Medical Center[NCT05807945]Phase 468 participants (Actual)Interventional2020-04-01Completed
A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102]Phase 4105 participants (Actual)Interventional2016-02-29Terminated
Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597]Phase 410 participants (Actual)Interventional2017-07-29Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.)
Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461]137 participants (Actual)Observational2009-07-31Completed
Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery[NCT02346110]Phase 440 participants (Actual)Interventional2015-04-30Completed
An Open Label Evaluation of the Safety and Clinical Utility of the Active, Separated System With Enhanced Controller (SSEC) Fentanyl 40 mcg for the Management of Acute Postoperative Pain in Pediatric Patients 12 to Less Than 18 Years of Age[NCT02395653]Phase 371 participants (Actual)Interventional2015-06-29Completed
Evaluating the Use of Sublingual Sufentanil in Patients With Suboxone Treatment Who Are Undergoing Ambulatory Surgery- a Case Series[NCT04716413]Phase 43 participants (Actual)Interventional2021-09-27Terminated (stopped due to Terminated early due to funding, lack of participants)
[NCT00440960]Phase 40 participants InterventionalCompleted
Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325]Phase 324 participants (Actual)Interventional2011-07-31Completed
Non-Interventional Pharmacogenetic Study of Patient / Proxy Controlled Analgesia in Children Undergoing Surgery[NCT01731873]182 participants (Actual)Observational2012-01-17Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Efficacy Phase: General Impression (GI) Score at 60 Minutes After First Dose

"Participants assessed their general impression (GI) of treatment efficacy for treated BTP episodes at 60 minutes after first dose of study drug. The validated, categorical 5-point Verbal Rating Scale (VRS) was used for this assessment and scored as follows:~0 =poor;~1 =fair;~2 =good;~3 =very good;~4 =excellent." (NCT01429051)
Timeframe: During the efficacy phase (II), at each episode of breakthrough pain, 60 minutes after first dose of study drug.

Interventionunits on a scale (Least Squares Mean)
Intranasal Fentanyl Spray (INFS)1.9
Placebo1.1

Induction Phase: Pain Intensity Difference at 10 Minutes (PID10) After Treatment

"During the efficacy phase participants assessed their pain intensity at each breakthrough pain (BTP) episode at 0 and 10 minutes after first dose using the 11-point Numerical Rating Scale (NRS) on a scale from 0 to 10, where 0 represents the absence of pain and 10 is worst possible pain. PID10 is calculated as the difference in pain intensity from time 0 to 10 minutes. A positive value is a decrease (improvement) of the pain; a ≥ 2-point difference is considered as clinically important." (NCT01429051)
Timeframe: During the efficacy phase (II), at each episode of breakthrough pain, at 0 and 10 minutes after first dose of study drug.

Interventionunits on a scale (Least Squares Mean)
Intranasal Fentanyl Spray (INFS)2.5
Placebo1.4

Efficacy Phase: Pain Intensity Difference (PID) at 5, 30, and 60 Minutes After First Dose of Study Drug

"During the efficacy phase participants assessed their pain intensity at each breakthrough pain (BTP) episode at 0, 5, 30 and 60 minutes after first dose using the 11-point Numerical Rating Scale (NRS) on a scale from 0 to 10, where 0 represents the absence of pain and 10 is worst possible pain. PID is calculated as the difference in pain intensity from time 0 to each time point. A positive value is a decrease (improvement) of the pain; a ≥ 2-point difference is considered as clinically important." (NCT01429051)
Timeframe: During the efficacy phase (II) each episode of breakthrough pain, at 0, 5, 30 and 60 minutes after study drug.

,
Interventionunits on a scale (Least Squares Mean)
PID at 5 minutesPID at 30 minutesPID at 60 minutes
Intranasal Fentanyl Spray (INFS)1.33.03.3
Placebo0.81.82.2

Efficacy Phase: Proportion of BTP Episodes With a Positive Response Defined as a ≥ 1, 2 or 3 Point Reduction in Pain Intensity

"Overall responder rate is defined as the proportion of breakthrough pain (BTP) episodes with a positive response to treatment. The following definitions of a positive response were analyzed: • greater than or equal to 1 point reduction in pain intensity (PI) from time 0, • greater than or equal to 2 point reduction in PI from time 0, and • greater than or equal to 3 point reduction in PI from time 0. Pain intensity was assessed using the 11-point Numerical Rating Scale (NRS) on a scale from 0 to 10, where 0 represents the absence of pain and 10 is worst possible pain." (NCT01429051)
Timeframe: During the efficacy phase (II) each episode of breakthrough pain, at 0, 5, 30 and 60 minutes after study drug

,
Interventionproportion of breakthrough pain episodes (Number)
≥ 1 point reduction in PI at 5 minutes≥ 1 point reduction in PI at 10 minutes≥ 1 point reduction in PI at 30 minutes≥ 1 point reduction in PI at 60 minutes≥ 2 point reduction in PI at 5 minutes≥ 2 point reduction in PI at 10 minutes≥ 2 point reduction in PI at 30 minutes≥ 2 point reduction in PI at 60 minutes≥ 3 point reduction in PI at 5 minutes≥ 3 point reduction in PI at 10 minutes≥ 3 point reduction in PI at 30 minutes≥ 3 point reduction in PI at 60 minutes
Intranasal Fentanyl Spray (INFS)0.610.740.810.860.330.510.600.650.180.320.450.50
Placebo0.450.550.660.690.240.310.410.480.170.240.340.48

Efficacy Phase: Proportion of BTP Episodes With a Positive Response Defined as a ≥ 33% or 50% Reduction in Pain Intensity

"Overall responder rate is defined as the proportion of breakthrough pain (BTP) episodes with a positive response to treatment. The following definitions of a positive response were analyzed: • Greater than 33% reduction in PI from time 0; • Greater than or equal to 50% reduction in PI from time 0. Pain intensity was assessed using the 11-point Numerical Rating Scale (NRS) on a scale from 0 to 10, where 0 represents the absence of pain and 10 is worst possible pain." (NCT01429051)
Timeframe: During the efficacy phase (II) each episode of breakthrough pain, at 0, 5, 30 and 60 minutes after study drug

,
Interventionproportion of breakthrough pain episodes (Number)
> 33% reduction in PI at 5 minutes> 33% reduction in PI at 10 minutes> 33% reduction in PI at 30 minutes> 33% reduction in PI at 60 minutes≥ 50% reduction in PI at 5 minutes≥ 50% reduction in PI at 10 minutes≥ 50% reduction in PI at 30 minutes≥ 50% reduction in PI at 60 minutes
Intranasal Fentanyl Spray (INFS)0.230.440.550.580.110.310.490.52
Placebo0.170.240.340.480.070.210.310.34

Efficacy Phase: Sum of Pain Intensity Differences (SPID0-60 and SPID0-30) Derived From PI Scores

"The SPID30 and SPID60 represent the average improvement in pain intensity over the 30 minute interval and 60 minute interval, respectively. SPIDt was calculated as the area under the curve (AUC) for Pain Intensity Difference over the time interval 0 to t minutes, respectively, divided by the length of the time interval (t minutes). A positive value is a decrease (improvement) of the pain.~Pain intensity was assessed at 0, 5, 30 and 60 minutes after study drug using the 11-point Numerical Rating Scale (NRS) on a scale from 0 to 10, where 0 represents the absence of pain and 10 is worst possible pain. PID is calculated as the difference in pain intensity from time 0 to each time point." (NCT01429051)
Timeframe: During the efficacy phase (II) each episode of breakthrough pain, at 0, 5, 30 and 60 minutes after study drug

,
Interventionunits on a scale (Least Squares Mean)
SPID30SPID60
Intranasal Fentanyl Spray (INFS)0.60.7
Placebo0.40.5

Incidence of Improvement or Worsening in Nasal Mucosa Sign or Abnormality Score

Medical examination of the nasal cavity by rhinoscopy was performed by an oto-rhino-laryngologist before the start of study treatment and at 12 weeks. Signs and any abnormalities were observed for each nostril using the following 4 points assessment scale: • 0 =not present; • 1 =present in a mild degree; • 2 =present in a moderate degree; • 3 =present in a severe degree. A difference in score of 1 or more from Baseline to the end of treatment represented a worsening, while a negative value indicated an improvement of the observed clinical sign. The oto-rhino-laryngologist also assessed whether worsening of a sign was related to study drug. Assessments for both left and right nostrils are presented together. The incidence is calculated as the number of assessments (n) in the improvement or worsening category divided by the number of assessments with a non-missing score for the Nasal Mucosa or Abnormality assessment. Only those signs or abnormalities with n>0 were included (NCT01429051)
Timeframe: Baseline and at 12 weeks

Interventionproportion of nostril assessments (Number)
Change of color: ImprovementChange of color: WorseningChange of color: Worsening related to study drugInflammation: ImprovementInflammation: WorseningInflammation: Worsening related to study drugSore nose: ImprovementSore nose: WorseningSore nose: Worsening related to study drugUlceration: ImprovementUlceration: WorseningUlceration: Worsening related to study drugDry nose: ImprovementDry nose: WorseningDry nose: Worsening related to study drugRunny nose: ImprovementRunny nose: WorseningRunny nose: Worsening related to study drugStuffed nose: ImprovementStuffed nose: WorseningStuffed nose: Worsening related to study drugOedema: ImprovementOedema: WorseningOedema: Worsening related to study drugEpistaxis: ImprovementEpistaxis: WorseningEpistaxis: Worsening related to study drug
Intranasal Fentanyl Spray (INFS)0.060.090.090.040.070.070.040.040.04NA0.040.040.090.06NA0.040.130.100.060.170.080.040.170.080.020.020.02

Number of Participants With Adverse Events (AEs)

The severity (intensity of each AE was assessed as mild (transient symptoms, no interference with daily activities), moderate (marked symptoms, moderate interference with daily activities), or severe (considerable interference with daily activities) by the investigator. Serious adverse events are defined as any untoward medical occurrence that at any dose results in death or is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity or is a congenital anomaly/birth defect. The investigator assessed each AE as either related or not related to study treatment. (NCT01429051)
Timeframe: 12 weeks

,,
Interventionparticipants (Number)
Any AEAny AE reported as related to treatmentNon-serious adverse eventsSerious adverse eventsDeathsSevere adverse eventsAEs leading to withdrawalAEs possibly associated with nasal intolerabilityAEs with an onset within 30 minutes of first dose
Efficacy Phase645212203
Titration Phase2314222222211
Tolerability Phase22617857365

Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit

Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours

Interventionminutes (Mean)
Placebo53.5
Modafinil61.0

Postanesthesia Quality Recovery Scale Score

Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery

Interventionunits on a scale (Mean)
Placebo-5.67
Modafinil-8.91

Assessment Of Adherence Of The SSEC System To Skin

The adhesion of each SSEC was evaluated immediately prior to removal at each 24-hour time point, or at early withdrawal. Adhesion was recorded using the following classification: System adhered to at least 90% of the application area with no edges unattached; System adhered between 75% and 89%; System was <75% adhered and not taped; System was secured with tape. The number of SSEC systems for all time points in each category is presented. Because of the descriptive nature of this study, no formal statistical hypothesis testing was performed. (NCT02395653)
Timeframe: Immediately prior to removal at each 24-hour time point, or at early withdrawal, for up to 3 consecutive days (up to 72 hours)

InterventionSSEC systems (Number)
≥90% of area with no edges unattached75% to 89%<75% adhered and not tapedSystem was secured with tapeNot assessed
SSEC Fentanyl976310

Assessment Of Participant's Ability To Use The SSEC

Investigator's assessment of participant's ability to use the SSEC system safely and effectively. The assessment consisted of a 4-level categorical evaluation (poor, fair, good, and excellent). Because of the descriptive nature of this study, no formal statistical hypothesis testing was performed. (NCT02395653)
Timeframe: Completed at the time of the participant's termination of study treatment (up to 72 hours after study drug administration)

Interventionparticipants (Number)
PoorFairGoodExcellentMissing
SSEC Fentanyl1210480

Change From Baseline To 1 Hour And 24 Hours In Skin Irritation Score After SSEC Removal

Skin irritation at the SSEC application site was to be assessed immediately prior to placement of the study system and at 1 and 24 hours after removal of each study system. The application site was to be scored using the following scale: 0=No evidence of irritation; 1=Minimal erythema, barely perceptible; 2=Definite erythema, readily visible, minimal edema, or minimal papular response; 3=Erythema and papules; 4=Definite edema; 5=Erythema, edema, and papules; 6=Vesicular eruption; 7=Strong reaction spreading beyond the application site. (NCT02395653)
Timeframe: Baseline, 1 hour and 24 hours after SSEC removal.

Interventionunits on a scale (Mean)
System 1, Hour 1System 1, Hour 24System 2, Hour 1System 2, Hour 24System 3, Hour 1System 3, Hour 24
SSEC Fentanyl1.11.81.01.61.00.8

Number Of Participants To Experience Clinically Relevant Respiratory Depression (CRRD)

Respiratory function and occurrence of CRRD was defined as simultaneous occurrence of bradypnoea (respiratory rate <10 breaths per minute for participants 9-15 years of age and sustained for 1 minute, or <8 breaths per minute for participants 16-17 years of age), with excessive sedation (that is, the participant is not easily aroused). (NCT02395653)
Timeframe: From the time of application of the first system through 7 days following end of study drug administration.

Interventionparticipants (Number)
BradypnoeaExcessive SedationSimultaneous Bradypnoea and Excessive Sedation
SSEC Fentanyl000

Reviews

7 reviews available for fentanyl and Nausea

ArticleYear
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
    Minerva anestesiologica, 2023, Volume: 89, Issue:5

    Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp

2023
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
    Minerva anestesiologica, 2023, Volume: 89, Issue:5

    Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp

2023
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
    Minerva anestesiologica, 2023, Volume: 89, Issue:5

    Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp

2023
α-2 agonists vs. fentanyl as adjuvants for spinal anesthesia in elective cesarean section: a meta-analysis.
    Minerva anestesiologica, 2023, Volume: 89, Issue:5

    Topics: Adjuvants, Anesthesia; Adjuvants, Pharmaceutic; Adrenergic alpha-2 Receptor Agonists; Anesthesia, Sp

2023
Fentanyl Buccal Soluble Film: A Review in Breakthrough Cancer Pain.
    Clinical drug investigation, 2016, Volume: 36, Issue:5

    Topics: Administration, Buccal; Analgesics, Opioid; Breakthrough Pain; Disease Management; Fentanyl; Humans;

2016
Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain.
    Current medical research and opinion, 2012, Volume: 28, Issue:5

    Topics: Administration, Oral; Analgesics, Opioid; Buprenorphine; Chronic Pain; Constipation; Fentanyl; Human

2012
The safety and efficacy of fentanyl iontophoretic transdermal system compared with morphine intravenous patient-controlled analgesia for postoperative pain management: an analysis of pooled data from three randomized, active-controlled clinical studies.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:5

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Female; Fentanyl; Fever; Humans; Iontophore

2007
[Combined subarachnoid-epidural technique for obstetric analgesia].
    Revista espanola de anestesiologia y reanimacion, 2000, Volume: 47, Issue:5

    Topics: Adjuvants, Anesthesia; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia,

2000
Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control.
    Drugs, 2001, Volume: 61, Issue:15

    Topics: Absorption; Administration, Cutaneous; Analgesia; Analgesics, Opioid; Digestive System; Drug Interac

2001
Drug therapy: analgetic drugs--the potent analgetics.
    The New England journal of medicine, 1972, Feb-03, Volume: 286, Issue:5

    Topics: Analgesics; Blood Circulation; Fentanyl; Humans; Intestines; Levallorphan; Meperidine; Methadone; Me

1972

Trials

84 trials available for fentanyl and Nausea

ArticleYear
Effect of additional equipotent fentanyl or sufentanil administration on recovery profiles during propofol-remifentanil-based anaesthesia in patients undergoing gynaecologic laparoscopic surgery: a randomized clinical trial.
    BMC anesthesiology, 2022, 04-29, Volume: 22, Issue:1

    Topics: Anesthesia; Delirium; Dizziness; Female; Fentanyl; Humans; Laparoscopy; Nausea; Propofol; Remifentan

2022
Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial.
    Contraception, 2023, Volume: 118

    Topics: Dilatation; Double-Blind Method; Female; Fentanyl; Gabapentin; Humans; Midazolam; Nausea; Pain; Pain

2023
Comparison of the Efficacies of Three Different Intrathecal Doses of Morphine in Achieving Postcesarean Delivery Analgesia.
    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2023, Volume: 38, Issue:5

    Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Cesarean Section; Double-Blind Method; Female; Fe

2023
Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a single ascending dose study in opioid-naïve healthy volunteers.
    Current medical research and opinion, 2017, Volume: 33, Issue:11

    Topics: Administration, Intravenous; Administration, Sublingual; Adult; Analgesics, Opioid; Female; Fentanyl

2017
The analgesic efficacy and safety of nefopam in patient-controlled analgesia after cardiac surgery: A randomized, double-blind, prospective study.
    The Journal of international medical research, 2014, Volume: 42, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Analgesics,

2014
Comparison of intrathecal bupivacaine, levobupivacaine for cesarean section.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2014, Volume: 97, Issue:7

    Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Section; Double-Blind Method; F

2014
Efficacy and tolerability of intranasal fentanyl spray in cancer patients with breakthrough pain.
    Clinical therapeutics, 2015, Mar-01, Volume: 37, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Breakthrough Pain; Cross-Over Studies; Double-Blind Method; Female;

2015
Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
    World journal of surgery, 2016, Volume: 40, Issue:12

    Topics: Administration, Intravenous; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opi

2016
Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
    World journal of surgery, 2016, Volume: 40, Issue:12

    Topics: Administration, Intravenous; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opi

2016
Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
    World journal of surgery, 2016, Volume: 40, Issue:12

    Topics: Administration, Intravenous; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opi

2016
Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.
    World journal of surgery, 2016, Volume: 40, Issue:12

    Topics: Administration, Intravenous; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opi

2016
Comparison of an Intraoperative Infusion of Dexmedetomidine, Fentanyl, and Remifentanil on Perioperative Hemodynamics, Sedation Quality, and Postoperative Pain Control.
    Journal of Korean medical science, 2016, Volume: 31, Issue:9

    Topics: Adolescent; Adult; Analgesics, Opioid; Blood Pressure; Dexmedetomidine; Double-Blind Method; Female;

2016
Comparison of ropivacaine with and without fentanyl vs bupivacaine with fentanyl for postoperative epidural analgesia in bilateral total knee replacement surgery.
    Journal of clinical anesthesia, 2017, Volume: 37

    Topics: Aged; Amides; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, L

2017
Omitting fentanyl reduces nausea and vomiting, without increasing pain, after sevoflurane for day surgery.
    European journal of anaesthesiology, 2008, Volume: 25, Issue:10

    Topics: Adult; Ambulatory Surgical Procedures; Female; Fentanyl; Humans; Male; Methyl Ethers; Nausea; Pain;

2008
Gastrointestinal symptoms under opioid therapy: a prospective comparison of oral sustained-release hydromorphone, transdermal fentanyl, and transdermal buprenorphine.
    European journal of pain (London, England), 2009, Volume: 13, Issue:7

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Antiemetics; Buprenor

2009
Efficacy and safety of transdermal fentanyl for treatment of oral mucositis pain caused by chemotherapy.
    Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:18

    Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Analgesics, Opioid; Antineoplastic Combined Chem

2008
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha

2010
Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study.
    Palliative medicine, 2010, Volume: 24, Issue:3

    Topics: Administration, Sublingual; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cross-Ov

2010
[Effects of preincisional epidural administration of lidocaine and fentanyl on postoperative pain management following hysterectomy].
    Zhonghua yi xue za zhi, 2002, Jun-10, Volume: 82, Issue:11

    Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Drug Therapy, Combination;

2002
A comparison of anaesthetic techniques for shock wave lithotripsy: the use of a remifentanil infusion alone compared to intermittent fentanyl boluses combined with a low dose propofol infusion.
    Anaesthesia, 2002, Volume: 57, Issue:9

    Topics: Adult; Ambulatory Care; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Combined; Anesthet

2002
[The effect of intrathecal fentanyl added to hyperbaric bupivacaine for caesarean section].
    Masui. The Japanese journal of anesthesiology, 2003, Volume: 52, Issue:4

    Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Endotracheal; Anesthesia, Obstetrical; Anesthesia, Spinal;

2003
[Effect of different methods for postoperative pain management on catecholamine response to abdominal surgery].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2003, Apr-18, Volume: 35, Issue:2

    Topics: Abdomen; Amides; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid;

2003
Efficacy and adverse effects of patient-controlled epidural or intravenous analgesia after major surgery.
    Chang Gung medical journal, 2004, Volume: 27, Issue:12

    Topics: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Intraveno

2004
[Low-dose 0.25% spinal levobupivacaine with epidural extension for cesarean section: comparison with 0.5% hyperbaric bupivacaine].
    Revista espanola de anestesiologia y reanimacion, 2006, Volume: 53, Issue:1

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local

2006
[Patient-controlled intravenous analgesia with sufentanil and fentanyl after thoracotomy: a comparative study].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2006, Volume: 26, Issue:2

    Topics: Adult; Analgesia, Patient-Controlled; Esophageal Neoplasms; Female; Fentanyl; Humans; Infusions, Int

2006
Oral sodium citrate increases nausea amongst elective Cesarean delivery patients.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2006, Volume: 53, Issue:8

    Topics: Administration, Oral; Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Intravenous;

2006
A randomized trial of crystalloid versus colloid solution for prevention of hypotension during spinal or low-dose combined spinal-epidural anesthesia for elective cesarean delivery.
    International journal of obstetric anesthesia, 2007, Volume: 16, Issue:1

    Topics: Adult; Analysis of Variance; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Combined; Bupiva

2007
Intrathecal morphine reduces breakthrough pain during labour epidural analgesia.
    British journal of anaesthesia, 2007, Volume: 98, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Spinal; Anesthet

2007
A randomized clinical trial of oral transmucosal fentanyl citrate versus intravenous morphine sulfate for initial control of pain in children with extremity injuries.
    Pediatric emergency care, 2007, Volume: 23, Issue:8

    Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Arm Injuries; Child; Female; Fentanyl; Humans;

2007
Bioequivalence following buccal and sublingual placement of fentanyl buccal tablet 400 microg in healthy subjects.
    Clinical drug investigation, 2008, Volume: 28, Issue:1

    Topics: Administration, Buccal; Administration, Sublingual; Adult; Analgesics, Opioid; Area Under Curve; Chr

2008
On-demand analgesia. A double-blind comparison of on-demand intravenous fentanyl with regular intramuscular morphine.
    Anaesthesia, 1983, Volume: 38, Issue:1

    Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Fentanyl; Humans; Injections, Intramuscular; I

1983
[The influence of the premedication on subjective postanaesthetic complaints in out-patients (author's transl)].
    Der Anaesthesist, 1980, Volume: 29, Issue:8

    Topics: Ambulatory Care; Atropine; Droperidol; Fentanyl; Humans; Nausea; Pentazocine; Preanesthetic Medicati

1980
Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery.
    Journal of clinical anesthesia, 1995, Volume: 7, Issue:4

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Anesthesia, Intravenous; Anesthetics, Inhalation; An

1995
Transdermal fentanyl in combination with initial intravenous dose titration by patient-controlled analgesia.
    Anti-cancer drugs, 1995, Volume: 6 Suppl 3

    Topics: Administration, Cutaneous; Analgesia, Patient-Controlled; Analgesics; Constipation; Dose-Response Re

1995
The introduction of patient-controlled analgesia into an isolated rural hospital.
    The Australian and New Zealand journal of surgery, 1995, Volume: 65, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Feasibility Studies; Fentanyl; Hospit

1995
Oral transmucosal fentanyl citrate premedication in patients undergoing outpatient dermatologic procedures.
    The Journal of dermatologic surgery and oncology, 1994, Volume: 20, Issue:12

    Topics: Administration, Oral; Adult; Aged; Ambulatory Surgical Procedures; Anti-Anxiety Agents; Anxiety; Blo

1994
Propofol-based anesthesia as compared with standard anesthetic techniques for middle ear surgery.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1995, Volume: 112, Issue:2

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Droperidol; Ear,

1995
Patient-controlled analgesia following caesarean section under general anaesthesia: a comparison of fentanyl with morphine.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:1

    Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthesia, General; Anesthesia, Obste

1995
Transdermal fentanyl in uncontrolled cancer pain: titration on a day-to-day basis as a procedure for safe and effective dose finding--a pilot study in 20 patients.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1994, Volume: 2, Issue:2

    Topics: Administration, Cutaneous; Administration, Oral; Fentanyl; Gastrointestinal Motility; Humans; Morphi

1994
Ketorolac versus fentanyl for gynaecological day-case surgery.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1993, Volume: 33, Issue:4

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Female; Fentanyl; Genital Diseases, Female; Human

1993
Posture and the spread of hyperbaric bupivacaine in parturients using the combined spinal epidural technique.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:10

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia, Epidural; Anesthesia, Obstetrical; A

1993
Prophylactic paracetamol for analgesia after vaginal termination of pregnancy.
    Anaesthesia and intensive care, 1993, Volume: 21, Issue:1

    Topics: Abortion, Induced; Acetaminophen; Ambulatory Surgical Procedures; Analgesia; Analgesics; Anesthesia,

1993
Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy.
    European journal of anaesthesiology, 1993, Volume: 10, Issue:2

    Topics: Acetaminophen; Adult; Ambulatory Care; Diclofenac; Double-Blind Method; Female; Fentanyl; Humans; In

1993
[Laparoscopic cholecystectomy: evaluation of intraoperative complications with respect to 2 different kinds of anesthesia].
    Minerva chirurgica, 1995, Volume: 50, Issue:10

    Topics: Adult; Anesthesia; Anesthesia, Intravenous; Anesthetics, Intravenous; Cholecystectomy, Laparoscopic;

1995
Incidence of nausea and vomiting in outpatients undergoing general anesthesia in relation to selection of intraoperative opioid.
    Journal of clinical anesthesia, 1996, Volume: 8, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alfentanil; Ambulatory Surgical Procedures; Analgesics,

1996
Epidural morphine vs hydromorphone in post-caesarean section patients.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:6

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Epidural; Anesth

1996
Comparison of diclofenac and tenoxicam for postoperative analgesia with and without fentanyl in children undergoing adenotonsillectomy or tonsillectomy.
    Paediatric anaesthesia, 1996, Volume: 6, Issue:6

    Topics: Adenoidectomy; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Blood Loss, Surgical; Ch

1996
The safety and efficacy of oral transmucosal fentanyl citrate for preoperative sedation in young children.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:6

    Topics: Administration, Oral; Analgesics, Opioid; Anesthesia Recovery Period; Anxiety; Anxiety, Separation;

1996
A comparison: the efficacy of sevoflurane-nitrous oxide or propofol-nitrous oxide for the induction and maintenance of general anesthesia.
    Journal of clinical anesthesia, 1996, Volume: 8, Issue:8

    Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Inhalation; An

1996
Evaluation of morphine versus fentanyl for postoperative analgesia after ambulatory surgical procedures.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:3

    Topics: Adult; Aged; Ambulatory Care; Female; Fentanyl; Humans; Male; Middle Aged; Morphine; Nausea; Palliat

1997
Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair. Rectal acetaminophen versus intravenous fentanyl-droperidol.
    Ophthalmology, 1997, Volume: 104, Issue:3

    Topics: Acetaminophen; Administration, Rectal; Analgesia; Analgesics; Anesthesia Recovery Period; Child; Chi

1997
Transdermal fentanyl system plus im ketorolac for the treatment of postoperative pain.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:4

    Topics: Administration, Cutaneous; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N

1997
Midazolam premedication increases sedation but does not prolong discharge times after brief outpatient general anesthesia for laparoscopic tubal sterilization.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Age Factors; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period;

1997
A randomized, double-blind, dose-response comparison of epidural fentanyl versus sufentanil analgesia after cesarean section.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Epidural; Anesth

1997
Ondansetron versus metoclopramide in the treatment of postoperative nausea and vomiting.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Antiemet

1997
[Total intravenous anesthesia with propofol and fentanyl for laparoscopic cholecystectomy].
    Masui. The Japanese journal of anesthesiology, 1997, Volume: 46, Issue:9

    Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Inhalatio

1997
Postoperative nausea and vomiting. A retrospective analysis in patients undergoing elective craniotomy.
    Journal of neurosurgical anesthesiology, 1997, Volume: 9, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Analysis of Variance; Anesthesia; Craniotomy; Female; Fentanyl

1997
Epidural infusion of bupivacaine 0.0625% plus fentanyl 3.3 micrograms/ml provides better postoperative analgesia than patient-controlled analgesia with intravenous morphine after gynaecological laparotomy.
    Anaesthesia and intensive care, 1997, Volume: 25, Issue:5

    Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Bupivaca

1997
Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:1

    Topics: Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthetics, D

1998
[A comparison of the incidence of postoperative nausea and vomiting after propofol-fentanyl anesthesia and that after nitrous oxide-isoflurane anesthesia].
    Masui. The Japanese journal of anesthesiology, 1998, Volume: 47, Issue:3

    Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Inhalati

1998
Therapeutic suggestions given during neurolept-anaesthesia decrease post-operative nausea and vomiting.
    European journal of anaesthesiology, 1998, Volume: 15, Issue:4

    Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Antiemetics; Antipsychotic A

1998
Antiemetic activity of propofol after sevoflurane and desflurane anesthesia for outpatient laparoscopic cholecystectomy.
    Anesthesiology, 1998, Volume: 89, Issue:4

    Topics: Adult; Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation; Antiemetics; Cholecystectom

1998
[Our negative experience with meperidine for the prevention of coughing during cataract surgery].
    Revista espanola de anestesiologia y reanimacion, 1999, Volume: 46, Issue:3

    Topics: Antitussive Agents; Cataract Extraction; Cough; Double-Blind Method; Fentanyl; Humans; Intraocular P

1999
Intra-subject variability in post-operative patient-controlled analgesia (PCA): is the patient equally satisfied with morphine, pethidine and fentanyl?
    Pain, 1999, Volume: 80, Issue:3

    Topics: Adult; Aged; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Fentanyl; Humans; Meperidi

1999
Combined spinal epidural for labour analgesia--duration, efficacy and side effects of adding sufentanil or fentanyl to bupivacaine intrathecally vs plain bupivacaine.
    Singapore medical journal, 1999, Volume: 40, Issue:10

    Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Female; Fentany

1999
Pain relief following day case laparoscopic tubal ligation with intra-peritoneal ropivacaine: a randomised double blind control study.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2000, Volume: 40, Issue:4

    Topics: Adult; Ambulatory Surgical Procedures; Amides; Analgesics, Opioid; Anesthetics, Local; Double-Blind

2000
[Comparison of ropivacaine and bupivacaine for epidural analgesia during labor].
    Revista espanola de anestesiologia y reanimacion, 2001, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Amides; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Apgar Sc

2001
[The efficacy and safety of continuous epidural analgesia versus intradural-epidural analgesia during labor].
    Revista espanola de anestesiologia y reanimacion, 2001, Volume: 48, Issue:5

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia Recovery Period; Bupivacaine; Cesarea

2001
The antagonist effect of naloxone hydrochloride after neuroleptanaesthesia during neurosurgery.
    Acta anaesthesiologica Scandinavica, 1976, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Blood Pressure; Clinical Trials as Topic; Dose-Respons

1976
Double blind comparison of fentanyl and sulfentanil in anesthesia.
    Acta anaesthesiologica Belgica, 1976, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Aged; Anesthesia, General; Blood Pressure; Clinical Trials as Topic; Double-Blind

1976
[Caudal block in children: analgesia and respiratory effect of the combination bupivacaine-fentanyl].
    Annales francaises d'anesthesie et de reanimation, 1992, Volume: 11, Issue:2

    Topics: Anesthesia, Caudal; Bupivacaine; Child; Child, Preschool; Drug Combinations; Fentanyl; Humans; Nause

1992
The incidence of postoperative nausea and vomiting: a retrospective comparison of alfentanil versus sufentanil.
    Military medicine, 1992, Volume: 157, Issue:2

    Topics: Adolescent; Adult; Age Factors; Alfentanil; Anesthetics; Female; Fentanyl; Humans; Incidence; Male;

1992
Does epidural fentanyl decrease the efficacy of epidural morphine after cesarean delivery?
    Anesthesia and analgesia, 1992, Volume: 74, Issue:5

    Topics: Adult; Anesthesia, Obstetrical; Cesarean Section; Female; Fentanyl; Humans; Injections, Epidural; In

1992
Side effects during continuous epidural infusion of morphine and fentanyl.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Carbon Dioxide; Female; Fentanyl; Hip Prosthesi

1992
Pain following thoracotomy. A randomised, double-blind comparison of lumbar versus thoracic epidural fentanyl.
    Anaesthesia, 1991, Volume: 46, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Double-Blind Method; Female; Fentan

1991
Opioid supplementation to propofol anaesthesia for outpatient abortion: a comparison between alfentanil, fentanyl and placebo.
    Acta anaesthesiologica Scandinavica, 1991, Volume: 35, Issue:8

    Topics: Abortion, Induced; Adolescent; Adult; Alfentanil; Anesthesia Recovery Period; Anesthesia, Intravenou

1991
Ibuprofen provides longer lasting analgesia than fentanyl after laparoscopic surgery.
    Anesthesia and analgesia, 1991, Volume: 73, Issue:3

    Topics: Administration, Oral; Double-Blind Method; Female; Fentanyl; Humans; Ibuprofen; Injections, Intraven

1991
Total intravenous anaesthesia with propofol or etomidate.
    European journal of anaesthesiology, 1991, Volume: 8, Issue:5

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Blood Pressure; Carbon Dioxide; Consciou

1991
A comparison of recovery in outpatients receiving fentanyl versus those receiving butorphanol.
    Journal of clinical anesthesia, 1989, Volume: 1, Issue:5

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Butorphanol; Dizziness; Double-Blind Met

1989
A comparison of clinical and psychological effects of fentanyl and nalbuphine in ambulatory gynecologic patients.
    Anesthesia and analgesia, 1987, Volume: 66, Issue:12

    Topics: Ambulatory Care; Anxiety; Clinical Trials as Topic; Double-Blind Method; Dreams; Female; Fentanyl; H

1987
[Complaints in the postoperative phase related to anesthetics].
    Der Anaesthesist, 1988, Volume: 37, Issue:12

    Topics: Adolescent; Adult; Alfentanil; Analgesics; Anesthesia, Inhalation; Clinical Trials as Topic; Enflura

1988
Isoflurane v fentanyl for outpatient laparoscopy.
    Acta anaesthesiologica Scandinavica, 1985, Volume: 29, Issue:3

    Topics: Adolescent; Adult; Akathisia, Drug-Induced; Anesthetics; Drug Evaluation; Female; Fentanyl; Humans;

1985
Nausea and vomiting after general anaesthesia with isoflurane, enflurane or fentanyl in combination with nitrous oxide and oxygen.
    European journal of anaesthesiology, 1988, Volume: 5, Issue:3

    Topics: Adult; Anesthesia, Inhalation; Enflurane; Female; Fentanyl; Humans; Hysterectomy; Isoflurane; Middle

1988
[Blood loss and nausea during legal abortion].
    Annales francaises d'anesthesie et de reanimation, 1985, Volume: 4, Issue:3

    Topics: Abortion, Legal; Adolescent; Adult; Anesthesia, Intravenous; Blood Volume; Female; Fentanyl; Humans;

1985
Etomidate versus thiopental for induction of anesthesia.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:9

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Anesthesia, General; Anesthesia, Inhalation; Anesthes

1985
Thalamonal as a pre-operative sedative.
    British journal of anaesthesia, 1968, Volume: 40, Issue:7

    Topics: Analysis of Variance; Benperidol; Blood Pressure; Clinical Trials as Topic; Drug Synergism; Female;

1968
Studies of drugs given before anaesthesia. 18. The synthetic opiates.
    British journal of anaesthesia, 1969, Volume: 41, Issue:11

    Topics: Analgesics; Clinical Trials as Topic; Dextromoramide; Female; Fentanyl; Humans; Hypotension; Levorph

1969

Other Studies

38 other studies available for fentanyl and Nausea

ArticleYear
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
    Journal of vascular and interventional radiology : JVIR, 2023, Volume: 34, Issue:4

    Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea;

2023
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
    Journal of vascular and interventional radiology : JVIR, 2023, Volume: 34, Issue:4

    Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea;

2023
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
    Journal of vascular and interventional radiology : JVIR, 2023, Volume: 34, Issue:4

    Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea;

2023
Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols.
    Journal of vascular and interventional radiology : JVIR, 2023, Volume: 34, Issue:4

    Topics: Embolization, Therapeutic; Female; Fentanyl; Hospitalization; Hospitals; Humans; Leiomyoma; Nausea;

2023
Prevalence of opioid-induced adverse events across opioids commonly used for analgesic treatment in Japan: a multicenter prospective longitudinal study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023, Oct-16, Volume: 31, Issue:12

    Topics: Analgesics, Opioid; Cancer Pain; Constipation; Delirium; Fentanyl; Humans; Hydromorphone; Japan; Lon

2023
Strong opioids and non-cancer chronic pain in Catalonia. An analysis of the family physicians prescription patterns.
    Revista espanola de anestesiologia y reanimacion, 2020, Volume: 67, Issue:2

    Topics: Analgesics, Opioid; Benzodiazepines; Chronic Pain; Female; Fentanyl; Health Care Surveys; Humans; La

2020
Comparison of the Effects of Sufentanil and Fentanyl in Intravenous Patient-Controlled Analgesia after Pediatric Moyamoya Surgery: A Retrospective Study.
    Pediatric neurosurgery, 2020, Volume: 55, Issue:1

    Topics: Administration, Intravenous; Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Child; C

2020
Quality of labour neuraxial analgesia and maternal satisfaction at a tertiary care teaching hospital: a prospective observational study.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2013, Volume: 60, Issue:8

    Topics: Adjuvants, Anesthesia; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Contro

2013
Lessons learned from hospice care.
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2013, Volume: 28, Issue:10

    Topics: Aged; Aged, 80 and over; Amitriptyline; Analgesics, Opioid; Drug Monitoring; Fentanyl; Health Servic

2013
Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014, Volume: 22, Issue:3

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Breakthrough Pain; Constipation; Female; Fentanyl;

2014
[Side Effects of Continuous Fentanyl Infusion for Postoperative Pain Relief in Children].
    Masui. The Japanese journal of anesthesiology, 2015, Volume: 64, Issue:8

    Topics: Adolescent; Anesthetics, Intravenous; Child; Child, Preschool; Fentanyl; Humans; Infant; Nausea; Pai

2015
Fentanyl transdermal matrix patch (Durotep MT patch; Durogesic DTrans; Durogesic SMAT): in adults with cancer-related pain.
    Drugs, 2008, Volume: 68, Issue:12

    Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Area Under Curve; Clinical Trials, Phase II as

2008
Differential response to IV carfentanil in chronic cocaine users and healthy controls.
    Addiction biology, 2012, Volume: 17, Issue:1

    Topics: Adult; Analgesics, Opioid; Brain; Cocaine-Related Disorders; Dizziness; Female; Fentanyl; Half-Life;

2012
Retrospective evaluation of intravenous fentanyl patient-controlled analgesia during labor.
    Journal of anesthesia, 2012, Volume: 26, Issue:2

    Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthesia, Intravenous; Apgar Score;

2012
Efficacy and safety of intraoperative intravenous methadone during general anaesthesia for caesarean delivery: a retrospective case-control study.
    International journal of obstetric anesthesia, 2013, Volume: 22, Issue:1

    Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Genera

2013
Side effects of opioids during short-term administration: effect of age, gender, and race.
    Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta

2003
Side effects of opioids during short-term administration: effect of age, gender, and race.
    Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta

2003
Side effects of opioids during short-term administration: effect of age, gender, and race.
    Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta

2003
Side effects of opioids during short-term administration: effect of age, gender, and race.
    Clinical pharmacology and therapeutics, 2003, Volume: 74, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta

2003
Practical oral sedation in dentistry. Part II--Clinical application of various oral sedatives and discussion.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2006, Volume: 27, Issue:9

    Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, Dental; Child; Child,

2006
[Feasibility to treat pediatric cancer pain with analgesics for adults and their efficacy].
    Ai zheng = Aizheng = Chinese journal of cancer, 2007, Volume: 26, Issue:8

    Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Co

2007
[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine].
    Masui. The Japanese journal of anesthesiology, 2007, Volume: 56, Issue:11

    Topics: Acetaminophen; Anesthetics, Intravenous; Aspirin; Chlorpheniramine; Cholecystectomy, Laparoscopic; D

2007
Ventilatory and mental effects of alfentanil and fentanyl.
    Acta anaesthesiologica Scandinavica, 1984, Volume: 28, Issue:1

    Topics: Adult; Alfentanil; Analgesics, Opioid; Depression, Chemical; Double-Blind Method; Female; Fentanyl;

1984
Continuous infusion of alfentanil.
    Acta anaesthesiologica Belgica, 1982, Volume: 33, Issue:2

    Topics: Adult; Alfentanil; Anesthesia; Blood Pressure; Domperidone; Droperidol; Female; Fentanyl; Heart Rate

1982
Enflurane suppression of complex ventricular dysrhythmias.
    Anesthesiology, 1982, Volume: 56, Issue:2

    Topics: Anesthesia; Arrhythmias, Cardiac; Enflurane; Fentanyl; Heart Ventricles; Humans; Male; Middle Aged;

1982
[Comparison of buprenorphine and fentanyl for postoperative pain relief by continuous epidural infusion].
    Masui. The Japanese journal of anesthesiology, 1993, Volume: 42, Issue:12

    Topics: Abdomen; Aged; Buprenorphine; Dizziness; Female; Fentanyl; Humans; Injections, Epidural; Male; Middl

1993
Intravenous ketamine or fentanyl prolongs postoperative analgesia after intrathecal neostigmine.
    Anesthesia and analgesia, 1996, Volume: 83, Issue:4

    Topics: Analgesia; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Dissociative; Anesthetics, Intraveno

1996
Nausea and vomiting in patients undergoing radiofrequency catheter ablation.
    American journal of critical care : an official publication, American Association of Critical-Care Nurses, 1997, Volume: 6, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Intravenous; Antiemetics; Cath

1997
Severe hyponatremia after transsphenoidal surgery for pituitary adenomas.
    Kidney international. Supplement, 1998, Volume: 64

    Topics: Adenoma; Adolescent; Adult; Aged; Anesthetics, Intravenous; Female; Fentanyl; Headache; Humans; Hypo

1998
Opioid substitution to reduce adverse effects in cancer pain management.
    The Medical journal of Australia, 1999, Jan-18, Volume: 170, Issue:2

    Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hospice Care; Humans; Male; Medical A

1999
Neostigmine as the fourth spinal component for labor analgesia?
    Anesthesiology, 2000, Volume: 93, Issue:6

    Topics: Analgesia, Obstetrical; Analgesics; Bupivacaine; Clonidine; Drug Compounding; Drug Therapy, Combinat

2000
[High doses of fentanyl as the sole anaesthetic agent and naloxone as its antagonist (author's transl)].
    Der Anaesthesist, 1975, Volume: 24, Issue:4

    Topics: Adolescent; Adult; Aged; Analgesia; Autonomic Nervous System; Child; Child, Preschool; Female; Fenta

1975
Laparoscopic cholecystectomy: the anaesthetist's point of view.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:8

    Topics: Age Factors; Anesthesia; Anesthesia Recovery Period; Anesthesia, Intravenous; Antiemetics; Cholecyst

1992
Is fentanyl effective for postoperative analgesia in day-surgery?
    Anaesthesia and intensive care, 1992, Volume: 20, Issue:1

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesia; Anesthesia

1992
Postoperative analgesia with epidural fentanyl.
    The Journal of the American Osteopathic Association, 1991, Volume: 91, Issue:6

    Topics: Analgesia, Epidural; Drug Eruptions; Fentanyl; Humans; Nausea; Pain, Postoperative; Retrospective St

1991
Vertigo after epidural morphine.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:7

    Topics: Adult; Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Obstetrical; Female; Fentanyl; Humans;

1990
Comparison of alfentanil with fentanyl for outpatient anesthesia.
    Anesthesiology, 1986, Volume: 64, Issue:1

    Topics: Adult; Alfentanil; Ambulatory Surgical Procedures; Analgesia; Anesthesia; Fentanyl; Humans; Nausea;

1986
Administration of metoclopramide for prevention of nausea and vomiting during epidural anesthesia for elective cesarean section.
    Anesthesiology, 1987, Volume: 66, Issue:4

    Topics: Anesthesia, Epidural; Cesarean Section; Female; Fentanyl; Gestational Age; Humans; Metoclopramide; M

1987
Use of fentanyl markedly increases nausea and vomiting in gynecological short stay patients.
    AANA journal, 1986, Volume: 54, Issue:4

    Topics: Ambulatory Care; Female; Fentanyl; Genital Diseases, Female; Humans; Nausea; Vomiting

1986
Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion.
    Journal of neuro-oncology, 1986, Volume: 3, Issue:4

    Topics: Adult; Aged; Brain Neoplasms; Carmustine; Carotid Arteries; Diazepam; Droperidol; Drug Therapy, Comb

1986
[A clinical comparison between 3 varieties of neuroleptic anesthesia].
    Lakartidningen, 1973, Apr-18, Volume: 70, Issue:16

    Topics: Anesthesia, Intravenous; Benperidol; Blood Pressure; Diazepam; Female; Fentanyl; Humans; Hydroxyzine

1973
Use of droperidol-fentanyl sedation for cardiac catheterization in children.
    American heart journal, 1974, Volume: 87, Issue:3

    Topics: Adolescent; Bradycardia; Cardiac Catheterization; Cardiac Volume; Child; Child, Preschool; Cognition

1974
Neuroleptanalgesia: a new concept in premedication.
    Journal of oral surgery (American Dental Association : 1965), 1971, Volume: 29, Issue:6

    Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Anesthesia, Intravenous; Benperidol; Child; Dental Serv

1971
A comparison of neuroleptanesthesia and halothane in neurosurgery.
    Archivum chirurgicum Neerlandicum, 1970, Volume: 22, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Blood Pressure; Child; Consciousness; Female; Fenta

1970