fentanyl has been researched along with Miosis in 6 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Miosis: Pupillary constriction. This may result from congenital absence of the dilatator pupillary muscle, defective sympathetic innervation, or irritation of the CONJUNCTIVA or CORNEA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In humans, fentanyl-induced miosis was completely blocked by 50mg naltrexone, and LY2456302 dose-dependently blocked miosis at 25 and 60 mg (minimal-to-no blockade at 4-10mg)." | 5.19 | Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human. ( Bell, RL; Gonzales, CR; Hart, JC; Lowe, SL; McKinzie, DL; McKinzie, JH; Mitch, CH; Need, AB; Rorick-Kehn, LM; Statnick, MA; Stoltz, RR; Suico, JG; Tauscher-Wisniewski, S; Weller, MA; Witcher, JW; Wong, CJ, 2014) |
| " We report a case of a 19-month-old girl who presented in coma and who was later found to have a fentanyl patch adhered to her back." | 3.77 | Toxic leukoencephalopathy due to transdermal fentanyl overdose. ( Bradin, SA; Foy, L; Seeyave, DM, 2011) |
| "5 microg/kg), dosed 1 hour after oral quinidine (600 mg) or placebo." | 2.71 | Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl. ( Altuntas, TG; Hoffer, C; Kharasch, ED; Whittington, D, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Helland, A | 1 |
| Brede, WR | 1 |
| Michelsen, LS | 1 |
| Gundersen, POM | 1 |
| Aarset, H | 1 |
| Skjølås, JE | 1 |
| Slørdal, L | 1 |
| Rorick-Kehn, LM | 1 |
| Witcher, JW | 1 |
| Lowe, SL | 1 |
| Gonzales, CR | 1 |
| Weller, MA | 1 |
| Bell, RL | 1 |
| Hart, JC | 1 |
| Need, AB | 1 |
| McKinzie, JH | 1 |
| Statnick, MA | 1 |
| Suico, JG | 1 |
| McKinzie, DL | 1 |
| Tauscher-Wisniewski, S | 1 |
| Mitch, CH | 1 |
| Stoltz, RR | 1 |
| Wong, CJ | 1 |
| Dey, M | 1 |
| Madill, SA | 1 |
| Pagano, D | 1 |
| Matthews, TD | 1 |
| Foy, L | 1 |
| Seeyave, DM | 1 |
| Bradin, SA | 1 |
| Kharasch, ED | 1 |
| Hoffer, C | 1 |
| Altuntas, TG | 1 |
| Whittington, D | 1 |
| Stuerenburg, HJ | 1 |
| Claassen, J | 1 |
| Eggers, C | 1 |
| Hansen, HC | 1 |
2 trials available for fentanyl and Miosis
| Article | Year |
|---|---|
Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human.
Topics: Adolescent; Adult; Animals; Benzamides; Cross-Over Studies; Dose-Response Relationship, Drug; Double | 2014 |
Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl.
Topics: Administration, Oral; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member | 2004 |
4 other studies available for fentanyl and Miosis
| Article | Year |
|---|---|
Two Hospitalizations and One Death After Exposure to Ortho-Fluorofentanyl.
Topics: Adult; Analgesics, Opioid; Drug Overdose; Fatal Outcome; Fentanyl; Hospitalization; Humans; Male; Mi | 2017 |
Transient visual loss secondary to retinitis pigmentosa and opioid-induced miosis.
Topics: Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Miosis; Mydriatics; Postoperative Complicat | 2008 |
Toxic leukoencephalopathy due to transdermal fentanyl overdose.
Topics: Accidents, Home; Administration, Cutaneous; Apnea; Child, Preschool; Coma; Decerebrate State; Delaye | 2011 |
Acute adverse reaction to fentanyl in a 55 year old man.
Topics: Cerebral Angiography; Chest Pain; Coma; Confusion; Diagnosis, Differential; Drug-Related Side Effect | 2000 |