fentanyl and Glioma
fentanyl has been researched along with Glioma in 19 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have observed that treatment of human glioma cells with morphine in the nanomolar range of concentration affects the mitochondrial membrane potential." | 7.72 | Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells. ( Arcuri, E; Arese, M; Bacchi, A; Cardelli, P; Citro, G; Mastronicola, D; Mercadante, S; Sarti, P, 2004) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 7.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| "Gliomas are the most common primary tumors in the central nervous system with poor prognosis." | 5.91 | Fentanyl inhibits cell invasion and migration by modulating NF-κB activation in glioma. ( Liu, DZ; Xu, SY, 2023) |
| "We have observed that treatment of human glioma cells with morphine in the nanomolar range of concentration affects the mitochondrial membrane potential." | 3.72 | Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells. ( Arcuri, E; Arese, M; Bacchi, A; Cardelli, P; Citro, G; Mastronicola, D; Mercadante, S; Sarti, P, 2004) |
| "Opiate receptors from NG108-15 neuroblastoma-glioma hybrid cell membranes were purified to apparent homogeneity in a form covalently labeled with the opiate affinity ligand 3-methylfentanylisothiocyanate (super-FIT)." | 3.67 | Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells. ( Burke, TR; Jacobson, AE; Klee, WA; Rice, KC; Simonds, WF, 1985) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 3.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| "Gliomas are the most common primary tumors in the central nervous system with poor prognosis." | 1.91 | Fentanyl inhibits cell invasion and migration by modulating NF-κB activation in glioma. ( Liu, DZ; Xu, SY, 2023) |
| " We describe here an analogue of 1 with an added C-terminal β-glucosylserine residue, Ser(β-Glc)NH2, a modification that has previously been shown to improve bioavailability of opioid peptides." | 1.40 | Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. ( Anand, JP; Jutkiewicz, EM; Mosberg, HI; Porter, V; Sobczyk-Kojiro, K; Traynor, JR; Yeomans, L, 2014) |
| "In animals without tumors, the temperature subcutaneously on the foot was 0." | 1.29 | Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model. ( Dahl, O; Krossnes, BK; Mella, O, 1996) |
Research
Studies (19)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (31.58) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Mosberg, HI | 1 |
| Yeomans, L | 1 |
| Anand, JP | 1 |
| Porter, V | 1 |
| Sobczyk-Kojiro, K | 1 |
| Traynor, JR | 1 |
| Jutkiewicz, EM | 1 |
| Liu, DZ | 1 |
| Xu, SY | 1 |
| Lin, YC | 1 |
| Liu, YT | 1 |
| Wu, ZF | 1 |
| Chan, SM | 1 |
| Wang, Y | 1 |
| Barker, K | 1 |
| Shi, S | 1 |
| Diaz, M | 1 |
| Mo, B | 1 |
| Gutstein, HB | 2 |
| Moulédous, L | 1 |
| Diaz, MF | 1 |
| Mastronicola, D | 1 |
| Arcuri, E | 1 |
| Arese, M | 1 |
| Bacchi, A | 1 |
| Mercadante, S | 1 |
| Cardelli, P | 1 |
| Citro, G | 1 |
| Sarti, P | 1 |
| Burke, TR | 2 |
| Bajwa, BS | 1 |
| Jacobson, AE | 3 |
| Rice, KC | 3 |
| Streaty, RA | 2 |
| Klee, WA | 3 |
| Uchida, M | 1 |
| Mima, M | 1 |
| Imanishi, T | 1 |
| Nitsu, T | 1 |
| Saito, K | 1 |
| Sawaragi, S | 1 |
| Todd, MM | 1 |
| Warner, DS | 1 |
| Sokoll, MD | 1 |
| Maktabi, MA | 1 |
| Hindman, BJ | 1 |
| Scamman, FL | 1 |
| Kirschner, J | 1 |
| Krossnes, BK | 1 |
| Mella, O | 1 |
| Dahl, O | 1 |
| Jiang, C | 3 |
| Pechstein, U | 1 |
| Nadstawek, J | 1 |
| Zentner, J | 1 |
| Schramm, J | 1 |
| Yan, H | 1 |
| Liang, W | 1 |
| Tobias, JD | 1 |
| Heideman, RL | 1 |
| Kim, CH | 1 |
| Rothman, RB | 1 |
| Mattson, MV | 1 |
| Bykov, V | 1 |
| George, C | 1 |
| Long, JB | 1 |
| Simonds, WF | 1 |
| Klein, DS | 1 |
| Klein, PW | 1 |
| Mahaley, MS | 1 |
| Jennett, WB | 1 |
| Barker, J | 1 |
| Fitch, W | 1 |
| McDowall, DG | 1 |
Clinical Trials (4)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anaesthesia for Supratentorial Tumor Resection : a Double-blind Comparison of Target Plasma Concentration of Propofol-remifentanil and Sevoflurane-sufentanil[NCT00389883] | Phase 3 | 69 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial[NCT00741351] | Phase 3 | 411 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| The Effect of Furosemide Versus Placebo on Brain Relaxation and Incidence of Significant Intravascular Volume Depletion in Human Subjects Receiving Mannitol[NCT01054404] | 23 participants (Actual) | Interventional | 2010-02-28 | Terminated (stopped due to Concern for volume depletion and electrolyte abnormalities in furosemide arm.) | |||
| Clinical Effectiveness of Hypertonic Sodium Lactate Infusion for Intraoperative Brain Relaxation in Patients Undergoing Scheduled Craniotomy for Supratentorial Brain Tumor Resection: Study Protocol of a Single Center Double-blind Randomized Controlled Pha[NCT04488874] | Phase 3 | 50 participants (Actual) | Interventional | 2020-09-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Acceptable vs. Unacceptable Brain Relaxation at Dural Opening
"Rating of brain relaxation will be on a 4-point scale:~0 = brain very relaxed under dura, acceptable~= brain adequately relaxed under dura, acceptable~= brain slightly tense under dura, acceptable~= brain very tense under bulging dura, unacceptable" (NCT01054404)
Timeframe: just prior to dural opening for each subject
| Intervention | units on a scale 0-3 (Mean) |
|---|---|
| Furosemide | 1.5 |
| Placebo | 1.3 |
Trials
3 trials available for fentanyl and Glioma
Other Studies
16 other studies available for fentanyl and Glioma
| Article | Year |
|---|---|
Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance.
Topics: Analgesics; Animals; Biological Availability; Drug Tolerance; Female; Glioma; Male; Mice; Mice, Inbr | 2014 |
Fentanyl inhibits cell invasion and migration by modulating NF-κB activation in glioma.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Fentanyl; Glioma; Humans; Narc | 2023 |
The successful application of high flow nasal cannula for awake craniotomy.
Topics: Adult; Airway Management; Analgesia; Analgesics, Opioid; Brain Neoplasms; Cannula; Conscious Sedatio | 2019 |
Blockade of PDGFR-β activation eliminates morphine analgesic tolerance.
Topics: Animals; Benzamides; Chronic Pain; Dose-Response Relationship, Drug; Drug Combinations; Drug Toleran | 2012 |
Modulation of extracellular signal-regulated kinase (ERK) activity by acute and chronic opioid treatment in neuronal and glial cell lines.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Diprenorphine; Drug Administration Schedule; Enzyme Ac | 2004 |
Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Cell Line, Tumor; Electron Transport Complex IV; Fentanyl | 2004 |
Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors.
Topics: Animals; Benzimidazoles; Cell Line; Cell Membrane; Chemical Phenomena; Chemistry; Drug Evaluation, P | 1984 |
[Cerebral herniation during anesthesia].
Topics: Adult; Brain; Brain Neoplasms; Cerebral Hemorrhage; Encephalocele; Female; Fentanyl; Glioma; Humans; | 1984 |
Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model.
Topics: Animals; Blood Pressure; Body Temperature; Butyrophenones; Fentanyl; Glioma; Hyperthermia, Induced; | 1996 |
[Normalization of acupuncture anesthesia used in operation of neoplasm in functional area or deep site of brain].
Topics: Acupuncture Analgesia; Acupuncture Points; Adjuvants, Anesthesia; Adolescent; Adult; Aged; Brain Neo | 1996 |
[Clinical application of combined acupuncture-drug anesthesia in cerebral functional area operation].
Topics: Acupuncture Analgesia; Adult; Aged; Anesthetics, Combined; Anesthetics, Intravenous; Brain Neoplasms | 1998 |
[Normalization of acupuncture anesthesia used in neurosurgery].
Topics: Acupuncture Analgesia; Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cerebellar Neopl | 1992 |
Primary central hyperventilation in a child with a brainstem glioma: management with continuous intravenous fentanyl.
Topics: Brain Neoplasms; Brain Stem; Child; Fentanyl; Glioma; Humans; Hyperventilation; Infusions, Intraveno | 1991 |
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.
Topics: Acylation; Adenylyl Cyclase Inhibitors; Analgesia; Animals; Brain; Cell Membrane; Chemical Phenomena | 1989 |
Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.
Topics: Affinity Labels; Animals; Cell Line; Fentanyl; Glioma; Glycoproteins; Macromolecular Substances; Mem | 1985 |
Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion.
Topics: Adult; Aged; Brain Neoplasms; Carmustine; Carotid Arteries; Diazepam; Droperidol; Drug Therapy, Comb | 1986 |