Page last updated: 2024-10-27

fentanyl and Glioma

fentanyl has been researched along with Glioma in 19 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"We have observed that treatment of human glioma cells with morphine in the nanomolar range of concentration affects the mitochondrial membrane potential."7.72Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells. ( Arcuri, E; Arese, M; Bacchi, A; Cardelli, P; Citro, G; Mastronicola, D; Mercadante, S; Sarti, P, 2004)
"A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas."7.67Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986)
"Gliomas are the most common primary tumors in the central nervous system with poor prognosis."5.91Fentanyl inhibits cell invasion and migration by modulating NF-κB activation in glioma. ( Liu, DZ; Xu, SY, 2023)
"We have observed that treatment of human glioma cells with morphine in the nanomolar range of concentration affects the mitochondrial membrane potential."3.72Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells. ( Arcuri, E; Arese, M; Bacchi, A; Cardelli, P; Citro, G; Mastronicola, D; Mercadante, S; Sarti, P, 2004)
"Opiate receptors from NG108-15 neuroblastoma-glioma hybrid cell membranes were purified to apparent homogeneity in a form covalently labeled with the opiate affinity ligand 3-methylfentanylisothiocyanate (super-FIT)."3.67Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells. ( Burke, TR; Jacobson, AE; Klee, WA; Rice, KC; Simonds, WF, 1985)
"A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas."3.67Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986)
"Gliomas are the most common primary tumors in the central nervous system with poor prognosis."1.91Fentanyl inhibits cell invasion and migration by modulating NF-κB activation in glioma. ( Liu, DZ; Xu, SY, 2023)
" We describe here an analogue of 1 with an added C-terminal β-glucosylserine residue, Ser(β-Glc)NH2, a modification that has previously been shown to improve bioavailability of opioid peptides."1.40Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. ( Anand, JP; Jutkiewicz, EM; Mosberg, HI; Porter, V; Sobczyk-Kojiro, K; Traynor, JR; Yeomans, L, 2014)
"In animals without tumors, the temperature subcutaneously on the foot was 0."1.29Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model. ( Dahl, O; Krossnes, BK; Mella, O, 1996)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19906 (31.58)18.7374
1990's7 (36.84)18.2507
2000's2 (10.53)29.6817
2010's3 (15.79)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Mosberg, HI1
Yeomans, L1
Anand, JP1
Porter, V1
Sobczyk-Kojiro, K1
Traynor, JR1
Jutkiewicz, EM1
Liu, DZ1
Xu, SY1
Lin, YC1
Liu, YT1
Wu, ZF1
Chan, SM1
Wang, Y1
Barker, K1
Shi, S1
Diaz, M1
Mo, B1
Gutstein, HB2
Moulédous, L1
Diaz, MF1
Mastronicola, D1
Arcuri, E1
Arese, M1
Bacchi, A1
Mercadante, S1
Cardelli, P1
Citro, G1
Sarti, P1
Burke, TR2
Bajwa, BS1
Jacobson, AE3
Rice, KC3
Streaty, RA2
Klee, WA3
Uchida, M1
Mima, M1
Imanishi, T1
Nitsu, T1
Saito, K1
Sawaragi, S1
Todd, MM1
Warner, DS1
Sokoll, MD1
Maktabi, MA1
Hindman, BJ1
Scamman, FL1
Kirschner, J1
Krossnes, BK1
Mella, O1
Dahl, O1
Jiang, C3
Pechstein, U1
Nadstawek, J1
Zentner, J1
Schramm, J1
Yan, H1
Liang, W1
Tobias, JD1
Heideman, RL1
Kim, CH1
Rothman, RB1
Mattson, MV1
Bykov, V1
George, C1
Long, JB1
Simonds, WF1
Klein, DS1
Klein, PW1
Mahaley, MS1
Jennett, WB1
Barker, J1
Fitch, W1
McDowall, DG1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Anaesthesia for Supratentorial Tumor Resection : a Double-blind Comparison of Target Plasma Concentration of Propofol-remifentanil and Sevoflurane-sufentanil[NCT00389883]Phase 369 participants (Actual)Interventional2006-11-30Completed
Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial[NCT00741351]Phase 3411 participants (Actual)Interventional2007-12-31Completed
The Effect of Furosemide Versus Placebo on Brain Relaxation and Incidence of Significant Intravascular Volume Depletion in Human Subjects Receiving Mannitol[NCT01054404]23 participants (Actual)Interventional2010-02-28Terminated (stopped due to Concern for volume depletion and electrolyte abnormalities in furosemide arm.)
Clinical Effectiveness of Hypertonic Sodium Lactate Infusion for Intraoperative Brain Relaxation in Patients Undergoing Scheduled Craniotomy for Supratentorial Brain Tumor Resection: Study Protocol of a Single Center Double-blind Randomized Controlled Pha[NCT04488874]Phase 350 participants (Actual)Interventional2020-09-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Acceptable vs. Unacceptable Brain Relaxation at Dural Opening

"Rating of brain relaxation will be on a 4-point scale:~0 = brain very relaxed under dura, acceptable~= brain adequately relaxed under dura, acceptable~= brain slightly tense under dura, acceptable~= brain very tense under bulging dura, unacceptable" (NCT01054404)
Timeframe: just prior to dural opening for each subject

Interventionunits on a scale 0-3 (Mean)
Furosemide1.5
Placebo1.3

Trials

3 trials available for fentanyl and Glioma

ArticleYear
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.
    Anesthesiology, 1993, Volume: 78, Issue:6

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma;

1993
Isoflurane plus nitrous oxide versus propofol for recording of motor evoked potentials after high frequency repetitive electrical stimulation.
    Electroencephalography and clinical neurophysiology, 1998, Volume: 108, Issue:2

    Topics: Adolescent; Adult; Alfentanil; Anesthetics, Inhalation; Anesthetics, Intravenous; Cerebellar Neoplas

1998
Effect of anaesthesia on intracranial pressure in patients with space-occupying lesions.
    Lancet (London, England), 1969, Jan-11, Volume: 1, Issue:7585

    Topics: Adolescent; Adult; Aged; Anesthesia, Endotracheal; Benperidol; Blood Pressure; Blood Volume; Brain A

1969

Other Studies

16 other studies available for fentanyl and Glioma

ArticleYear
Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance.
    Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7

    Topics: Analgesics; Animals; Biological Availability; Drug Tolerance; Female; Glioma; Male; Mice; Mice, Inbr

2014
Fentanyl inhibits cell invasion and migration by modulating NF-κB activation in glioma.
    Brain research, 2023, 06-15, Volume: 1809

    Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Fentanyl; Glioma; Humans; Narc

2023
The successful application of high flow nasal cannula for awake craniotomy.
    Journal of clinical anesthesia, 2019, Volume: 55

    Topics: Adult; Airway Management; Analgesia; Analgesics, Opioid; Brain Neoplasms; Cannula; Conscious Sedatio

2019
Blockade of PDGFR-β activation eliminates morphine analgesic tolerance.
    Nature medicine, 2012, Feb-19, Volume: 18, Issue:3

    Topics: Animals; Benzamides; Chronic Pain; Dose-Response Relationship, Drug; Drug Combinations; Drug Toleran

2012
Modulation of extracellular signal-regulated kinase (ERK) activity by acute and chronic opioid treatment in neuronal and glial cell lines.
    Journal of neurochemistry, 2004, Volume: 90, Issue:6

    Topics: Animals; Blotting, Western; Cell Line, Tumor; Diprenorphine; Drug Administration Schedule; Enzyme Ac

2004
Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells.
    Cellular and molecular life sciences : CMLS, 2004, Volume: 61, Issue:23

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Cell Line, Tumor; Electron Transport Complex IV; Fentanyl

2004
Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Benzimidazoles; Cell Line; Cell Membrane; Chemical Phenomena; Chemistry; Drug Evaluation, P

1984
[Cerebral herniation during anesthesia].
    Masui. The Japanese journal of anesthesiology, 1984, Volume: 33, Issue:4

    Topics: Adult; Brain; Brain Neoplasms; Cerebral Hemorrhage; Encephalocele; Female; Fentanyl; Glioma; Humans;

1984
Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model.
    International journal of radiation oncology, biology, physics, 1996, Sep-01, Volume: 36, Issue:2

    Topics: Animals; Blood Pressure; Body Temperature; Butyrophenones; Fentanyl; Glioma; Hyperthermia, Induced;

1996
[Normalization of acupuncture anesthesia used in operation of neoplasm in functional area or deep site of brain].
    Zhen ci yan jiu = Acupuncture research, 1996, Volume: 21, Issue:2

    Topics: Acupuncture Analgesia; Acupuncture Points; Adjuvants, Anesthesia; Adolescent; Adult; Aged; Brain Neo

1996
[Clinical application of combined acupuncture-drug anesthesia in cerebral functional area operation].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1998, Volume: 18, Issue:3

    Topics: Acupuncture Analgesia; Adult; Aged; Anesthetics, Combined; Anesthetics, Intravenous; Brain Neoplasms

1998
[Normalization of acupuncture anesthesia used in neurosurgery].
    Zhen ci yan jiu = Acupuncture research, 1992, Volume: 17, Issue:1

    Topics: Acupuncture Analgesia; Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cerebellar Neopl

1992
Primary central hyperventilation in a child with a brainstem glioma: management with continuous intravenous fentanyl.
    Pediatrics, 1991, Volume: 88, Issue:4

    Topics: Brain Neoplasms; Brain Stem; Child; Fentanyl; Glioma; Humans; Hyperventilation; Infusions, Intraveno

1991
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Acylation; Adenylyl Cyclase Inhibitors; Analgesia; Animals; Brain; Cell Membrane; Chemical Phenomena

1989
Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:15

    Topics: Affinity Labels; Animals; Cell Line; Fentanyl; Glioma; Glycoproteins; Macromolecular Substances; Mem

1985
Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion.
    Journal of neuro-oncology, 1986, Volume: 3, Issue:4

    Topics: Adult; Aged; Brain Neoplasms; Carmustine; Carotid Arteries; Diazepam; Droperidol; Drug Therapy, Comb

1986