Page last updated: 2024-10-27

fentanyl and Coma

fentanyl has been researched along with Coma in 21 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"Time to first coma was associated with fentanyl and midazolam doses (p=0."7.79Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. ( Cossette, M; Leger, C; Michaud, V; Skrobik, Y; Turgeon, J, 2013)
"Illicit opioids, consisting largely of fentanyl, novel synthetic opioids, and adulterants, are the primary cause of drug overdose fatality in the United States."4.31Opioid overdoses involving xylazine in emergency department patients: a multicenter study. ( Aldy, K; Amaducci, A; Brent, J; Calello, D; Hendrickson, R; Hughes, A; Judge, B; Krotulski, AJ; Kurt, A; Levine, M; Logan, BK; Love, JS; Manini, AF; Pizon, A; Schwarz, E; Shulman, J; Vargas-Torres, C; Walton, SE; Wax, P; Wiegan, T, 2023)
"We compared two sedation regimens (propofol-remifentanil, period P2, vs midazolam-fentanyl, period P1) among comatose TTM-treated CA survivors."3.88Comparison of two sedation regimens during targeted temperature management after cardiac arrest. ( Ben Hadj Salem, O; Bougouin, W; Cariou, A; Champigneulle, B; Charpentier, J; Chiche, JD; Dumas, F; Geri, G; Guillemet, L; Legriel, S; Mira, JP; Paul, M; Sandroni, C, 2018)
"Time to first coma was associated with fentanyl and midazolam doses (p=0."3.79Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. ( Cossette, M; Leger, C; Michaud, V; Skrobik, Y; Turgeon, J, 2013)
" We report a case of a 19-month-old girl who presented in coma and who was later found to have a fentanyl patch adhered to her back."3.77Toxic leukoencephalopathy due to transdermal fentanyl overdose. ( Bradin, SA; Foy, L; Seeyave, DM, 2011)
"Five cases of post narcotic delirium, somnolence or coma are interpreted as central anticholinergic syndromes as they were reversed by physostigmine."3.66[Physostigmine reversal of central anticholinergic syndrome induced by midazolam/fentanyl, benzoctamine/buprenorphine and etomidate/carticaine or by atropine/promethazine/pethidine for premedication? (author's transl)]. ( Jost, U; Ruppert, M; Schmid, A, 1982)
"The early recognition of psychogenic coma can result in reduced iatrogenic complications, hospital cost, and physician anxiety."2.44Psychogenic coma following upper endoscopy: a case report and review of the literature. ( Downs, JW; Durning, SJ; Young, PE, 2008)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19905 (23.81)18.7374
1990's0 (0.00)18.2507
2000's4 (19.05)29.6817
2010's10 (47.62)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Love, JS1
Levine, M1
Aldy, K1
Brent, J1
Krotulski, AJ1
Logan, BK1
Vargas-Torres, C1
Walton, SE1
Amaducci, A1
Calello, D1
Hendrickson, R1
Hughes, A1
Kurt, A1
Judge, B1
Pizon, A1
Schwarz, E1
Shulman, J1
Wiegan, T1
Wax, P1
Manini, AF1
Tanios, M1
Nguyen, HM1
Le, QA1
Park, H1
Devlin, JW1
Müller, S1
Nussbaumer, S1
Plitzko, G1
Ludwig, R1
Weinmann, W1
Krähenbühl, S1
Liakoni, E1
Paul, M1
Bougouin, W1
Dumas, F1
Geri, G1
Champigneulle, B1
Guillemet, L1
Ben Hadj Salem, O1
Legriel, S1
Chiche, JD1
Charpentier, J1
Mira, JP1
Sandroni, C2
Cariou, A1
Fraser, GL1
Worby, CP1
Riker, RR1
Gusmao-Flores, D1
Carvalho, JP1
Quarantini, LC1
Granata, R1
Bossi, P1
Bertulli, R1
Saita, L1
Soar, J1
Friberg, H1
Downs, JW1
Young, PE1
Durning, SJ1
Bektas, F1
Eken, C1
Sayrac, V1
Chamorro, C1
Borrallo, JM1
Romera, MA1
Foy, L1
Seeyave, DM1
Bradin, SA1
Skrobik, Y1
Leger, C1
Cossette, M1
Michaud, V1
Turgeon, J1
Behrman, A1
Goertemoeller, S1
Boulard, G1
Maurette, P2
Pouguet, P1
Dautheriben, M1
Viallefont, E1
Besse, JL1
Dabadie, P2
Sabathié, M1
Jost, U1
Schmid, A1
Ruppert, M1
Stuerenburg, HJ1
Claassen, J1
Eggers, C1
Hansen, HC1
Chang, J1
Fish, KJ1
Brule, JF1
Thicoipe, M1
Claverie, JP1
Mostert, JW1
Evers, JL1
Hobika, GH1
Moore, RH1
Ambrus, JL1

Reviews

1 review available for fentanyl and Coma

ArticleYear
Psychogenic coma following upper endoscopy: a case report and review of the literature.
    Military medicine, 2008, Volume: 173, Issue:5

    Topics: Adult; Anesthetics, Intravenous; Coma; Endoscopy, Gastrointestinal; Female; Fentanyl; Fundoplication

2008

Other Studies

20 other studies available for fentanyl and Coma

ArticleYear
Opioid overdoses involving xylazine in emergency department patients: a multicenter study.
    Clinical toxicology (Philadelphia, Pa.), 2023, Volume: 61, Issue:3

    Topics: Adult; Analgesics, Opioid; Coma; Drug Overdose; Emergency Service, Hospital; Fentanyl; Humans; Opiat

2023
Fentanyl- and midazolam-induced coma each influence days of mechanical ventilation and 28-day mortality.
    Intensive care medicine, 2021, Volume: 47, Issue:7

    Topics: Coma; Fentanyl; Humans; Hypnotics and Sedatives; Midazolam; Respiration, Artificial

2021
Recreational use of carfentanil - a case report with laboratory confirmation.
    Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:2

    Topics: Adolescent; Analgesics, Opioid; Coma; Fentanyl; Glasgow Coma Scale; Humans; Illicit Drugs; Male; Tre

2018
Comparison of two sedation regimens during targeted temperature management after cardiac arrest.
    Resuscitation, 2018, Volume: 128

    Topics: Adult; Aged; Anesthetics, Intravenous; Coma; Deep Sedation; Drug Therapy, Combination; Female; Fenta

2018
Dissecting sedation-induced delirium.
    Critical care medicine, 2013, Volume: 41, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member

2013
Benzodiazepines and delirium: the best option for the right patient.
    Critical care medicine, 2013, Volume: 41, Issue:10

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Coma; Cy

2013
Rapid-onset opioids for the treatment of breakthrough cancer pain: two cases of drug abuse.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:5

    Topics: Analgesics, Opioid; Breakthrough Pain; Chemoradiotherapy; Coma; Fentanyl; Gastrointestinal Stromal T

2014
Does this comatose survivor of cardiac arrest have a poor prognosis?
    Intensive care medicine, 2016, Volume: 42, Issue:1

    Topics: Analgesics, Opioid; Anesthetics, Intravenous; Body Temperature; Coma; Electrocardiography; Electroen

2016
Letters.
    The Ulster medical journal, 2016, Volume: 85, Issue:3

    Topics: Administration, Inhalation; Adult; Analgesics, Opioid; Coma; Drug Packaging; Fentanyl; Humans; Male;

2016
Opioid toxicity as a result of oral/transmucosal administration of transdermal fentanyl patch.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2009, Volume: 16, Issue:6

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Apnea; Coma; Fentanyl; G

2009
Therapeutic hypothermia after cardiac arrest.
    The New England journal of medicine, 2011, 01-13, Volume: 364, Issue:2

    Topics: Analgesics; Coma; Fentanyl; Heart Arrest; Humans; Hypnotics and Sedatives; Hypothermia, Induced; Mid

2011
Toxic leukoencephalopathy due to transdermal fentanyl overdose.
    Pediatric emergency care, 2011, Volume: 27, Issue:9

    Topics: Accidents, Home; Administration, Cutaneous; Apnea; Child, Preschool; Coma; Decerebrate State; Delaye

2011
Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors.
    Critical care medicine, 2013, Volume: 41, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member

2013
A sticky situation: toxicity of clonidine and fentanyl transdermal patches in pediatrics.
    Journal of emergency nursing, 2007, Volume: 33, Issue:3

    Topics: Accidents; Administration, Cutaneous; Analgesics, Opioid; Antihypertensive Agents; Clonidine; Coma;

2007
[Withdrawal syndrome after stopping fentanyl sedation in neurological intensive care].
    Annales francaises d'anesthesie et de reanimation, 1983, Volume: 2, Issue:2

    Topics: Coma; Critical Care; Fentanyl; Humans; Neurologic Examination; Pupil; Substance Withdrawal Syndrome

1983
[Physostigmine reversal of central anticholinergic syndrome induced by midazolam/fentanyl, benzoctamine/buprenorphine and etomidate/carticaine or by atropine/promethazine/pethidine for premedication? (author's transl)].
    Der Anaesthesist, 1982, Volume: 31, Issue:1

    Topics: Adult; Aged; Anthracenes; Atropine; Benzodiazepines; Buprenorphine; Carticaine; Coma; Delirium; Etom

1982
Acute adverse reaction to fentanyl in a 55 year old man.
    Journal of neurology, neurosurgery, and psychiatry, 2000, Volume: 69, Issue:2

    Topics: Cerebral Angiography; Chest Pain; Coma; Confusion; Diagnosis, Differential; Drug-Related Side Effect

2000
Acute respiratory arrest and rigidity after anesthesia with sufentanil: a case report.
    Anesthesiology, 1985, Volume: 63, Issue:6

    Topics: Acute Disease; Adult; Anesthesia, General; Anesthetics; Apnea; Coma; Fentanyl; Humans; Male; Muscle

1985
[Role of early care and cerebral lesions in the mortality of young patients with cranial injuries. Preliminary study concerning 92 deaths].
    Minerva anestesiologica, 1985, Volume: 51, Issue:10

    Topics: Adolescent; Adult; Brain Injuries; Child; Child, Preschool; Coma; Female; Fentanyl; Humans; Infant;

1985
Cardiorespiratory effects of anaesthesia with morphine or fentanyl in chronic renal failure and cerebral toxicity after morphine.
    British journal of anaesthesia, 1971, Volume: 43, Issue:11

    Topics: Anesthesia, Intravenous; Blood Pressure; Blood Volume; Carbon Dioxide; Cardiac Output; Coma; Fentany

1971