Page last updated: 2024-10-27

fentanyl and Aura

fentanyl has been researched along with Aura in 25 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Research Excerpts

ExcerptRelevanceReference
"This prospective study evaluated the effects of propofol sedation on the incidence of intraoperative seizures and the adequacy of electrocorticographic (ECoG) recordings during awake craniotomy performed for the management of refractory epilepsy."9.08Propofol sedation during awake craniotomy for seizures: electrocorticographic and epileptogenic effects. ( Craen, RA; Eliasziw, M; Gelb, AW; Girvin, JP; Herrick, IA; Kirkby, J; McLachlan, RS; Parrent, AG, 1997)
"A 6-year-old girl with severe epilepsy received an orthopedic surgery of the right hand under new total intravenous anesthesia with droperidol, fentanyl and ketamine."7.68[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--5. An anesthetic experience of a pediatric patient with severe epilepsy]. ( Araki, I; Ishihara, H; Koh, H; Matsuki, A; Shirasaki, S; Takagi, H, 1991)
"This prospective study evaluated the effects of propofol sedation on the incidence of intraoperative seizures and the adequacy of electrocorticographic (ECoG) recordings during awake craniotomy performed for the management of refractory epilepsy."5.08Propofol sedation during awake craniotomy for seizures: electrocorticographic and epileptogenic effects. ( Craen, RA; Eliasziw, M; Gelb, AW; Girvin, JP; Herrick, IA; Kirkby, J; McLachlan, RS; Parrent, AG, 1997)
"A 6-year-old girl with severe epilepsy received an orthopedic surgery of the right hand under new total intravenous anesthesia with droperidol, fentanyl and ketamine."3.68[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--5. An anesthetic experience of a pediatric patient with severe epilepsy]. ( Araki, I; Ishihara, H; Koh, H; Matsuki, A; Shirasaki, S; Takagi, H, 1991)
", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule."1.43Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016)
"Seizure outcome was graded: I (seizure free without medication), II (seizure free with medication), III (> 50% seizure reduction) or IV (< 50% seizure reduction)."1.35Anesthesia and electrocorticography for epilepsy surgery: a Jordanian experience. ( Al-Ghanem, SS; Al-Oweidi, AS; Al-Qudah, AA; Tamimi, AF, 2009)
"When sevoflurane concentration was reduced to 1."1.31[Fentanyl administration during sevoflurane anesthesia suppresses spike waves from epileptic focus on electrocorticogram]. ( Asada, A; Koyama, S; Makino, Y; Morino, M; Nishikawa, K; Tanaka, K, 2002)
"Propofol has been proposed as a sedative agent during awake craniotomies."1.31The effect of propofol on intraoperative electrocorticography and cortical stimulation during awake craniotomies in children. ( Black, PM; Eldredge, EA; Kull, L; Madsen, JR; Riviello, JJ; Rockoff, MA; Soriano, SG; Wang, FK, 2000)
"Electroencephalographic (EEG) seizures, grouped and isolated spikes, and significant increases of multineuronal activity (MUA) were elicited by fentanyl, 50 micrograms/kg iv, in these brain structures."1.29Effects of diazepam on fentanyl-induced epileptoid EEG activity and increase of multineuronal firing in limbic and mesencephalic brain structures. ( Antonio-Ocampo, A; Cervantes, M; Chávez-Carrillo, I; Contreras-Gómez, A; Ruelas, R, 1996)
" In order to define the minimal dosage of fentanyl required, the MD was titrated according to increases or decreases in the heart rate and/or mean arterial pressure exceeding 15 per cent of baseline ward values."1.28Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy. ( Modica, PA; Spitznagel, EL; Tempelhoff, R, 1990)
"Fentanyl was administered intravenously at two dose levels (200 micrograms X kg-1, n = 5; and 400 micrograms X kg-1, n = 8)."1.27Fentanyl-induced seizures activate subcortical brain metabolism. ( Keifer-Goodman, J; Kohlenberger, RW; Maekawa, T; Shapiro, HM; Tommasino, C, 1984)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19906 (24.00)18.7374
1990's9 (36.00)18.2507
2000's9 (36.00)29.6817
2010's1 (4.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Waszkielewicz, AM1
Gunia-Krzyżak, A1
Powroźnik, B1
Słoczyńska, K1
Pękala, E1
Walczak, M1
Bednarski, M1
Żesławska, E1
Nitek, W1
Marona, H1
Al-Ghanem, SS1
Al-Oweidi, AS1
Tamimi, AF1
Al-Qudah, AA1
Stricker, PA1
Kraemer, FW1
Ganesh, A1
König, MW1
Mahmoud, MA1
Fujiwara, H1
Hemasilpin, N1
Lee, KH1
Rose, DF1
Koyama, S1
Makino, Y1
Tanaka, K1
Morino, M1
Nishikawa, K1
Asada, A1
Szmuk, P1
Kee, S1
Pivalizza, EG1
Warters, RD1
Abramson, DC1
Ezri, T1
Nersesyan, H1
Hyder, F1
Rothman, DL1
Blumenfeld, H1
Almeida, AN1
Tavares, C1
Tibano, A1
Sasaki, S1
Murata, KN1
Marino, R1
Jugovac, I1
Imas, O1
Hudetz, AG1
McLachlan, RS2
Gloor, P1
Avoli, M1
Rudehill, A1
Gordon, E1
Grepe, A1
Widén, L1
Tommasino, C1
Maekawa, T1
Shapiro, HM1
Keifer-Goodman, J1
Kohlenberger, RW1
Opitz, A1
Marschall, M1
Degen, R1
Koch, D1
Gignac, E1
Manninen, PH1
Gelb, AW2
Cervantes, M1
Antonio-Ocampo, A1
Ruelas, R1
Contreras-Gómez, A1
Chávez-Carrillo, I1
Herrick, IA1
Craen, RA1
Girvin, JP1
Parrent, AG1
Eliasziw, M1
Kirkby, J1
Decoo, D1
Destée, A1
Cascino, GD1
Velasco, M1
Brito, F1
Jimenez, F1
Gallegos, M1
Velasco, AL1
Velasco, F1
Soriano, SG1
Eldredge, EA1
Wang, FK1
Kull, L1
Madsen, JR1
Black, PM1
Riviello, JJ1
Rockoff, MA1
Fisher, RS1
Frost, JJ1
Koh, H1
Takagi, H1
Araki, I1
Shirasaki, S1
Ishihara, H1
Matsuki, A1
Tempelhoff, R1
Modica, PA1
Spitznagel, EL1
Welling, EC1
Donegan, J1
Brindle, GF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Magnesium Sulphate Versus Fentanyl as Adjuvants to Propofol for Monitored Anesthesia Care During Burr-hole Surgery for Chronic Subdural Hematoma: Randomized Clinical Trial[NCT03854812]Phase 232 participants (Actual)Interventional2019-03-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for fentanyl and Aura

ArticleYear
PET studies in epilepsy.
    Acta neurologica Belgica, 1997, Volume: 97, Issue:3

    Topics: Brain; Carbon Radioisotopes; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Fentanyl; Flumaze

1997
Pharmacological activation.
    Electroencephalography and clinical neurophysiology. Supplement, 1998, Volume: 48

    Topics: Alfentanil; Anesthetics, Intravenous; Convulsants; Electroencephalography; Epilepsy; Fentanyl; Human

1998
Epilepsy.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1991, Volume: 32, Issue:4

    Topics: Adult; Carbon Radioisotopes; Child; Epilepsy; Fentanyl; Humans; Receptors, Opioid; Tomography, Emiss

1991

Trials

2 trials available for fentanyl and Aura

ArticleYear
Comparison of fentanyl, sufentanil and alfentanil during awake craniotomy for epilepsy.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:5 Pt 1

    Topics: Adult; Alfentanil; Anesthesia, Intravenous; Cerebral Cortex; Consciousness; Craniotomy; Double-Blind

1993
Propofol sedation during awake craniotomy for seizures: electrocorticographic and epileptogenic effects.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:6

    Topics: Adjuvants, Anesthesia; Adult; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Cerebral Cort

1997

Other Studies

20 other studies available for fentanyl and Aura

ArticleYear
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru

2016
Anesthesia and electrocorticography for epilepsy surgery: a Jordanian experience.
    Middle East journal of anaesthesiology, 2009, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Anesthesia, General; Anesthetics; Child; Craniotomy; Electroencephalography; Epil

2009
Severe remifentanil-induced acute opioid tolerance following awake craniotomy in an adolescent.
    Journal of clinical anesthesia, 2009, Volume: 21, Issue:2

    Topics: Adolescent; Analgesics, Opioid; Anesthesia; Consciousness; Craniotomy; Drug Tolerance; Epilepsy; Fen

2009
Influence of anesthetic management on quality of magnetoencephalography scan data in pediatric patients: a case series.
    Paediatric anaesthesia, 2009, Volume: 19, Issue:5

    Topics: Adolescent; Analgesics, Non-Narcotic; Anesthesia; Anesthetics, Intravenous; Artifacts; Child; Child,

2009
[Fentanyl administration during sevoflurane anesthesia suppresses spike waves from epileptic focus on electrocorticogram].
    Masui. The Japanese journal of anesthesiology, 2002, Volume: 51, Issue:7

    Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Inhalation; Anesthetics, Combined; Anesthetics, Inhalation

2002
Anaesthesia for magnetoencephalography in children with intractable seizures.
    Paediatric anaesthesia, 2003, Volume: 13, Issue:9

    Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Child, Preschool; Chloral Hy

2003
Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2004, Volume: 24, Issue:6

    Topics: Animals; Bicuculline; Brain Mapping; Cerebral Cortex; Cerebrovascular Circulation; Convulsants; Drop

2004
Dexmedetomidine for awake craniotomy without laryngeal mask.
    Arquivos de neuro-psiquiatria, 2005, Volume: 63, Issue:3B

    Topics: Adult; Anesthetics, Combined; Conscious Sedation; Craniotomy; Dexmedetomidine; Epilepsy; Female; Fen

2005
Supraspinal anesthesia: behavioral and electroencephalographic effects of intracerebroventricularly infused pentobarbital, propofol, fentanyl, and midazolam.
    Anesthesiology, 2006, Volume: 105, Issue:4

    Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Brain; Consciousness; Data Interpretation, Stat

2006
Differential participation of some 'specific' and 'non-specific' thalamic nuclei in generalized spike and wave discharges of feline generalized penicillin epilepsy.
    Brain research, 1984, Jul-30, Volume: 307, Issue:1-2

    Topics: Animals; Cats; Cerebral Cortex; Computers; Electroencephalography; Epilepsy; Evoked Potentials; Fent

1984
The epileptogenicity of neurolept anaesthesia in patients during and after neuroradiological examinations with metrizamide.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:4

    Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Child, Preschool; Electroencephalography; Epilepsy;

1983
Fentanyl-induced seizures activate subcortical brain metabolism.
    Anesthesiology, 1984, Volume: 60, Issue:4

    Topics: Action Potentials; Animals; Autoradiography; Brain; Cerebral Cortex; Dose-Response Relationship, Dru

1984
General anesthesia in patients with epilepsy and status epilepticus.
    Advances in neurology, 1983, Volume: 34

    Topics: Anesthesia, General; Anesthesia, Inhalation; Droperidol; Electroencephalography; Epilepsy; Etomidate

1983
Effects of diazepam on fentanyl-induced epileptoid EEG activity and increase of multineuronal firing in limbic and mesencephalic brain structures.
    Archives of medical research, 1996,Winter, Volume: 27, Issue:4

    Topics: Animals; Cats; Diazepam; Electroencephalography; Epilepsy; Fentanyl; Limbic System; Male; Mesencepha

1996
Effect of fentanyl and naloxone on a thalamic induced painful response in intractable epileptic patients.
    Stereotactic and functional neurosurgery, 1998, Volume: 71, Issue:2

    Topics: Adult; Analgesics, Opioid; Electric Stimulation Therapy; Electrocardiography; Electroencephalography

1998
The effect of propofol on intraoperative electrocorticography and cortical stimulation during awake craniotomies in children.
    Paediatric anaesthesia, 2000, Volume: 10, Issue:1

    Topics: Adolescent; Anesthetics, Intravenous; Cerebral Cortex; Child; Cognition; Craniotomy; Electroencephal

2000
[Clinical study on total intravenous anesthesia with droperidol, fentanyl and ketamine--5. An anesthetic experience of a pediatric patient with severe epilepsy].
    Masui. The Japanese journal of anesthesiology, 1991, Volume: 40, Issue:3

    Topics: Anesthesia, Intravenous; Child; Droperidol; Epilepsy; Female; Fentanyl; Humans; Ketamine; Orthopedic

1991
Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Anesthesia, Intravenous; Anticonvulsants; Carbamazepine; Craniotomy; Drug Interac

1990
Neuroleptanalgesia using alfentanil for awake craniotomy.
    Anesthesia and analgesia, 1989, Volume: 68, Issue:1

    Topics: Adolescent; Adult; Alfentanil; Awareness; Brain Mapping; Cognition; Consciousness; Epilepsy; Female;

1989
The use of neuroleptic agents in a neurosurgical unit.
    Clinical neurosurgery, 1969, Volume: 16

    Topics: Benperidol; Cerebral Angiography; Chlorpromazine; Craniocerebral Trauma; Electrodes; Epilepsy; Fenta

1969