fentanyl and Apnea
fentanyl has been researched along with Apnea in 67 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Apnea: A transient absence of spontaneous respiration.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "In cats sedated with dexmedetomidine, fentanyl could be considered to reduce the alfaxalone induction dose, cough reflex and laryngeal response to ETI and to improve the overall quality of ETI." | 9.69 | Effect of intravenous fentanyl on cough reflex and quality of endotracheal intubation in cats. ( Martín Bellido, V; Martínez I Ferré, B; McDonald, H; Vettorato, E, 2023) |
| "Apnea occurrence and duration of manual ventilation, as well as frequency and severity of movement, coughing, breath holding, and laryngospasm were recorded." | 9.19 | Effects of fentanyl administration before induction of anesthesia and placement of the Laryngeal Mask Airway: a randomized, placebo-controlled trial. ( Gasanova, I; Joshi, GP; Kamali, A; Meng, J; Rosero, E, 2014) |
| " Identifying mechanisms to counter progression to fatal respiratory apnea during opioid overdose is desirable, but difficult to study in vivo." | 7.96 | Kölliker-Fuse/Parabrachial complex mu opioid receptors contribute to fentanyl-induced apnea and respiratory rate depression. ( Levitt, ES; Saunders, SE, 2020) |
| "The objective of this study was to characterize the propofol-fentanyl interaction in Beagles for four pharmacodynamic endpoints: apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation." | 7.85 | Propofol-fentanyl interaction in Beagles - Apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation. ( Iizuka, T; Kanazawa, H; Masui, K; Miyabe-Nishiwaki, T; Nishimura, R, 2017) |
| " We intubated the patient immediately for apnea that occurred after extubation." | 7.79 | [A case of tracheal intubation for apnea with epidural opioid in recovery room after operation under general anesthesia]. ( Ouchi, K; Sugiyama, K; Uno, H, 2013) |
| "Our previous study has shown that activating peripheral μ-receptors is necessary for switching the bronchopulmonary C-fibers (PCFs)-mediated rapid shallow breathing (RSB) into an apnea by systemic administration of fentanyl." | 7.78 | Contribution of central μ-receptors to switching pulmonary C-fibers-mediated rapid shallow breathing into an apnea by fentanyl in anesthetized rats. ( Xu, F; Zhang, C; Zhang, Z; Zhuang, J, 2012) |
| " Specifically, to determine if the ampakine CX717, which has been proven metabolically stable and safe for human use, can prevent and rescue from severe fentanyl-induced apnea." | 7.75 | Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats. ( Ding, X; Funk, GD; Greer, JJ; Ren, J, 2009) |
| " The incidence of hypoxemia (oxyhemoglobin saturation less than 90%) and apnea (no spontaneous respiratory effort for 15 s) and the ventilatory response to carbon dioxide were evaluated." | 7.68 | Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. ( Ashburn, MA; Bailey, PL; East, KA; Moll, JW; Pace, NL; Stanley, TH, 1990) |
| "In cats sedated with dexmedetomidine, fentanyl could be considered to reduce the alfaxalone induction dose, cough reflex and laryngeal response to ETI and to improve the overall quality of ETI." | 5.69 | Effect of intravenous fentanyl on cough reflex and quality of endotracheal intubation in cats. ( Martín Bellido, V; Martínez I Ferré, B; McDonald, H; Vettorato, E, 2023) |
| " Complications including apnea, hypotension, hypoxia, nausea, and vomiting, along with gastroenterologist satisfaction and patients' pain score (based on Wong-Baker faces pain assessment scale), were recorded by a checklist." | 5.51 | Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial. ( Aghaali, M; Ahmadpour, S; Alemi, F; Aminnejad, R; Hormati, A; Hormati, M; Sabouri, SM; Saeidi, M; Shafiee, H, 2022) |
| " Our main outcomes were pain assessed during the procedure and up to 10 minutes after the procedure with a validated scale; episodes of bradycardia; episodes of apnea; and hypotension requiring medical therapy." | 5.41 | Non-opioid analgesics for procedural pain in neonates. ( Bruschettini, M; Persad, E; Pizarro, AB, 2023) |
| " Opioids may result in an increase in episodes of apnea." | 5.41 | Opioids for procedural pain in neonates. ( Borys, F; Bruschettini, M; Kinoshita, M; Olsson, E, 2023) |
| " The evidence is very uncertain about the effect of opioids on episodes of bradycardia, hypotension or severe apnea." | 5.41 | Opioids for procedural pain in neonates. ( Borys, F; Bruschettini, M; Kinoshita, M; Olsson, E, 2023) |
| " Our main outcomes were successful LP on first attempt, total number of LP attempts, episodes of bradycardia, pain assessed with validated scales, episodes of desaturation, number of episodes of apnea, and number of infants with one or more episodes of apnea." | 5.41 | Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants. ( Bruschettini, M; Hedayati, E; Olsson, E; Pessano, S; Romantsik, O, 2023) |
| "Apnea occurrence and duration of manual ventilation, as well as frequency and severity of movement, coughing, breath holding, and laryngospasm were recorded." | 5.19 | Effects of fentanyl administration before induction of anesthesia and placement of the Laryngeal Mask Airway: a randomized, placebo-controlled trial. ( Gasanova, I; Joshi, GP; Kamali, A; Meng, J; Rosero, E, 2014) |
| " Apnea periods >20 seconds and decreases in SaO2 <90% occurred more frequently in group R (31." | 5.14 | Remifentanil versus fentanyl for esophagogastroduodenoscopy in children. ( Hirsh, I; Lerner, A; Pacht, A; Pizov, R; Reuveni, A; Segol, O; Shnaider, I, 2010) |
| " Frequency of apnea was significantly higher in the remifentanil group (P < 0." | 5.13 | Intravenous remifentanil and propofol for gastroscopy. ( Liu, J; Si, YY; Wang, X; Wu, JC; Xu, ZY; Xue, FS; Zuo, YX, 2008) |
| "The incidence of typical airway irritation events was lower with fentanyl than with saline (cough, 2." | 5.12 | Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children. ( Kim, C; Kim, H; Kim, S; Lee, J; Oh, Y; Park, H, 2006) |
| "4%), including hypotension in 5, hypoxemia in 7, and apnea in 5." | 5.11 | Propofol for deep procedural sedation in the ED. ( Baire, M; Frazee, BW; Lowery, D; Park, RS, 2005) |
| "To assess effects of anesthesia and opioids, we studied 13 children with obstructive sleep apnea (OSA, age 4." | 5.10 | Effects of OSA, inhalational anesthesia, and fentanyl on the airway and ventilation of children. ( Hinder, M; McBrien, F; Stewart, P; Waters, KA; Wharton, S, 2002) |
| "In phase 1, apnea occurred in eight of nine B patients (89%) compared with one of seven C patients (14%; P < ." | 5.08 | Comparison of continuous infusion of fentanyl to bolus dosing in neonates after surgery. ( Denver, KK; McKenzie, S; Moreland, S; Thilo, EH; Townsend, SF; Vaughn, PR, 1996) |
| " Despite the same duration of preoxygenation, younger children were more susceptible than elder ones to the risk of hypoxemia during apnea." | 5.08 | Study of the safe threshold of apneic period in children during anesthesia induction. ( An, G; Deng, XM; Liao, X; Luo, LK; Tong, SY; Xue, FS, 1996) |
| " Postextubation apnea characteristics were similar between the groups." | 5.08 | Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. ( Asokumar, B; Carroll, J; Cheng, DC; David, T; Karski, J; Mickle, D; Nierenberg, H; Peniston, C; Raveendran, G; Roger, S; Sandler, A; Tong, J; Zelovitsky, J, 1996) |
| " Low-dose intravenous ketamine as the primary anesthetic following premedication with fentanyl and midazolam, and in conjunction with nitrous oxide, appeared to produce less hypoxia, hypercarbia, and apnea than when methohexital was used." | 5.07 | A double-blind comparison of low-dose intravenous ketamine and methohexital in adults. ( Anderson, JA; Blankstein, KC, 1991) |
| " While these results are consistent with those for apnea, contingency analyses of the oxygen saturation and EtCO2 results were not statistically significant." | 5.07 | The safety and efficacy of outpatient midazolam intravenous sedation for oral surgery with and without fentanyl. ( Beirne, OR; Fiset, L; Martin, M; Milgrom, P; Tay, KM; Weinstein, P, 1993) |
| " Data from the D and C patients was treated separately from that for TOP and ERPC patients; marked differences were found in incremental requirements for methohexitone, the frequency of apnea, the observed respiratory rates, and the mean arterial pressure." | 5.05 | A clinical trial of alfentanil as an adjuvant for short anaesthetic procedures. ( Hull, CJ; Jacobson, L, 1983) |
| " Patients in whom anesthesia was induced with etomidate had a greater incidence of pain on injection and myoclonus and a lesser incidence of apnea than patients in whom anesthesia was induced with thiopental." | 5.05 | Etomidate versus thiopental for induction of anesthesia. ( Giese, JL; Nelissen, RH; Pace, NL; Stanley, TH; Stockham, RJ, 1985) |
| " The following 4 cardiopulmonary complications were assessed: hypoxia, hypotension, arrhythmias, and apnea." | 4.82 | Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis. ( Khandwala, F; Lopez, R; Qadeer, MA; Vargo, JJ; Zuccaro, G, 2005) |
| " Inspiratory neurons and a subset of inspiratory/expiratory phase-spanning neurons were either silenced or had reduced firing frequency during fentanyl-induced apnea, which was reversed upon administration of naloxone." | 4.12 | Fentanyl effects on respiratory neuron activity in the dorsolateral pons. ( Baekey, DM; Levitt, ES; Saunders, SE, 2022) |
| " Clinical features included typical opioid symptoms such as unconsciousness, respiratory depression, and apnea." | 3.81 | Opioid intoxications involving butyrfentanyl, 4-fluorobutyrfentanyl, and fentanyl from the Swedish STRIDA project. ( Bäckberg, M; Beck, O; Helander, A; Jönsson, KH, 2015) |
| " We intubated the patient immediately for apnea that occurred after extubation." | 3.79 | [A case of tracheal intubation for apnea with epidural opioid in recovery room after operation under general anesthesia]. ( Ouchi, K; Sugiyama, K; Uno, H, 2013) |
| "Intravenous bolus injection of morphine causes a vagal-mediated brief apnea (∼3 s), while continuous injection, via action upon central μ-opioid receptor (MOR), arrests ventilation (>20 s) that is eliminated by stimulating central 5-hydroxytryptamine 1A receptors (5HT(1A)Rs)." | 3.78 | 8-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT1A receptors in the nucleus tractus solitarius. ( Xu, F; Zhang, C; Zhang, Z; Zhuang, J, 2012) |
| " We report a case of a 19-month-old girl who presented in coma and who was later found to have a fentanyl patch adhered to her back." | 3.77 | Toxic leukoencephalopathy due to transdermal fentanyl overdose. ( Bradin, SA; Foy, L; Seeyave, DM, 2011) |
| "Individual Foxy-paO(2), Foxy-ptiO(2), and Licox-ptiO(2) courses were related to episodes of apnea." | 3.77 | A novel technique for monitoring of fast variations in brain oxygen tension using an uncoated fluorescence quenching probe (Foxy AL-300). ( Boehme, S; David, M; Engelhard, K; Hartmann, EK; Klein, KU; Markstaller, K; Szczyrba, M, 2011) |
| "The desaturation response time of SpO(2) to 95% after apnea was 82." | 3.76 | Comparison of desaturation and resaturation response times between transmission and reflectance pulse oximeters. ( Ahn, HJ; Choi, SJ; Kang, JG; Kang, JY; Kim, CS; Kim, JA; Kim, JK; Sim, WS; Yang, MK, 2010) |
| " Specifically, to determine if the ampakine CX717, which has been proven metabolically stable and safe for human use, can prevent and rescue from severe fentanyl-induced apnea." | 3.75 | Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats. ( Ding, X; Funk, GD; Greer, JJ; Ren, J, 2009) |
| " The adverse event (AE) rate was 18% and included apnea (10%), inadequate sedation (3%), bradycardia (2%), desaturation (1%), hypotension (1%) and bag-valve-mask use (1%)." | 3.73 | Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS). ( Mensour, M; Michaud, J; Pineau, R; Sahai, V, 2006) |
| " They also increased reactivity to CO(2) by lowering the phrenic nerve apnea threshold and shifting the phrenic nerve-CO(2) response curve to lower et(CO(2)) levels." | 3.72 | Dopamine1 receptor agonists reverse opioid respiratory network depression, increase CO2 reactivity. ( Lalley, PM, 2004) |
| " Additionally, fentanyl produced immediate apnea necessitating tracheal intubation and mechanical ventilation." | 3.69 | Interaction of fentanyl and nitrous oxide on peripheral and cerebral hemodynamics in newborn lambs. ( Koehler, RC; Traystman, RJ; Yaster, M, 1994) |
| " The incidence of hypoxemia (oxyhemoglobin saturation less than 90%) and apnea (no spontaneous respiratory effort for 15 s) and the ventilatory response to carbon dioxide were evaluated." | 3.68 | Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. ( Ashburn, MA; Bailey, PL; East, KA; Moll, JW; Pace, NL; Stanley, TH, 1990) |
| " The potency ratios of the fentanyl drugs to produce apnea and depress minute volume were dissimilar." | 3.68 | Multiple opioid receptors mediate the respiratory depressant effects of fentanyl-like drugs in the rat. ( Kitchen, I; Yeadon, M, 1990) |
| " The major possible complication is that of apnea, which requires that resuscitation equipment be available." | 3.67 | Use of i.v. fentanyl in the outpatient treatment of pediatric facial trauma. ( Billmire, DA; Gregory, RO; Neale, HW, 1985) |
| "Buprenorphine causes limited respiratory depression with a ceiling effect at higher doses, while fentanyl causes dose-dependent respiratory depression with apnoea at high dose levels." | 2.72 | Opioid-induced respiratory effects: new data on buprenorphine. ( Dahan, A, 2006) |
| "Sevoflurane is an alternative to propofol for induction of anaesthesia and has a lower incidence of apnoea." | 2.71 | Comparison of propofol and sevoflurane for laryngeal mask airway insertion. ( Coskuner, I; Demirel, CB; Huseyinoglu, UA; Kati, I; Silay, E; Yagmur, C, 2003) |
| "Midazolam pretreatment was associated with a significant reduction in propofol dose requirement in both younger and older patients." | 2.70 | Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults. ( Bhaskaran, NC; Claydon, P; Cressey, DM; Reilly, CS, 2001) |
| " With a dosage of ratio of 1:10, i." | 2.64 | [The hypnotic effect of fentanyl and sulfentanil. An electro-encephalographic comparison (author's transl)]. ( Dick, E; Doenicke, A; Grote, B; Kugler, J; Laub, M, 1977) |
Research
Studies (67)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (22.39) | 18.7374 |
| 1990's | 17 (25.37) | 18.2507 |
| 2000's | 12 (17.91) | 29.6817 |
| 2010's | 14 (20.90) | 24.3611 |
| 2020's | 9 (13.43) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Aminnejad, R | 1 |
| Hormati, A | 1 |
| Shafiee, H | 1 |
| Alemi, F | 1 |
| Hormati, M | 1 |
| Saeidi, M | 1 |
| Ahmadpour, S | 1 |
| Sabouri, SM | 1 |
| Aghaali, M | 1 |
| Saunders, SE | 2 |
| Baekey, DM | 1 |
| Levitt, ES | 2 |
| Persad, E | 1 |
| Pizarro, AB | 1 |
| Bruschettini, M | 4 |
| Kinoshita, M | 2 |
| Olsson, E | 3 |
| Borys, F | 2 |
| Martín Bellido, V | 1 |
| Martínez I Ferré, B | 1 |
| McDonald, H | 1 |
| Vettorato, E | 1 |
| Pessano, S | 1 |
| Romantsik, O | 1 |
| Hedayati, E | 1 |
| Algera, MH | 1 |
| Olofsen, E | 1 |
| Moss, L | 1 |
| Dobbins, RL | 1 |
| Niesters, M | 1 |
| van Velzen, M | 1 |
| Groeneveld, GJ | 1 |
| Heuberger, J | 1 |
| Laffont, CM | 1 |
| Dahan, A | 2 |
| Ouchi, K | 1 |
| Uno, H | 1 |
| Sugiyama, K | 1 |
| Joshi, GP | 1 |
| Kamali, A | 1 |
| Meng, J | 1 |
| Rosero, E | 1 |
| Gasanova, I | 1 |
| Lewis, SR | 1 |
| Nicholson, A | 1 |
| Reed, SS | 1 |
| Kenth, JJ | 1 |
| Alderson, P | 1 |
| Smith, AF | 1 |
| Bäckberg, M | 1 |
| Beck, O | 1 |
| Jönsson, KH | 1 |
| Helander, A | 1 |
| Iizuka, T | 1 |
| Masui, K | 1 |
| Miyabe-Nishiwaki, T | 1 |
| Kanazawa, H | 1 |
| Nishimura, R | 1 |
| Xu, ZY | 1 |
| Wang, X | 1 |
| Si, YY | 1 |
| Wu, JC | 1 |
| Zuo, YX | 1 |
| Xue, FS | 2 |
| Liu, J | 1 |
| Ren, J | 1 |
| Ding, X | 1 |
| Funk, GD | 1 |
| Greer, JJ | 1 |
| Choi, SJ | 1 |
| Ahn, HJ | 1 |
| Yang, MK | 1 |
| Kim, CS | 1 |
| Sim, WS | 1 |
| Kim, JA | 1 |
| Kang, JG | 1 |
| Kim, JK | 1 |
| Kang, JY | 1 |
| Bektas, F | 1 |
| Eken, C | 1 |
| Sayrac, V | 1 |
| Tan, AS | 1 |
| Wang, CY | 1 |
| Taha, SK | 1 |
| El-Khatib, MF | 1 |
| Baraka, AS | 1 |
| Haidar, YA | 1 |
| Abdallah, FW | 1 |
| Zbeidy, RA | 1 |
| Siddik-Sayyid, SM | 1 |
| Hirsh, I | 1 |
| Lerner, A | 1 |
| Shnaider, I | 1 |
| Reuveni, A | 1 |
| Pacht, A | 1 |
| Segol, O | 1 |
| Pizov, R | 1 |
| Klein, KU | 1 |
| Boehme, S | 1 |
| Hartmann, EK | 1 |
| Szczyrba, M | 1 |
| David, M | 1 |
| Markstaller, K | 1 |
| Engelhard, K | 1 |
| Foy, L | 1 |
| Seeyave, DM | 1 |
| Bradin, SA | 1 |
| Levitzky, BE | 1 |
| Lopez, R | 2 |
| Dumot, JA | 1 |
| Vargo, JJ | 2 |
| Zhuang, J | 2 |
| Zhang, Z | 2 |
| Zhang, C | 2 |
| Xu, F | 2 |
| Kati, I | 1 |
| Demirel, CB | 1 |
| Huseyinoglu, UA | 1 |
| Silay, E | 1 |
| Yagmur, C | 1 |
| Coskuner, I | 1 |
| Lalley, PM | 1 |
| Frazee, BW | 1 |
| Park, RS | 1 |
| Lowery, D | 1 |
| Baire, M | 1 |
| Qadeer, MA | 1 |
| Khandwala, F | 1 |
| Zuccaro, G | 1 |
| Lee, J | 1 |
| Oh, Y | 1 |
| Kim, C | 1 |
| Kim, S | 1 |
| Park, H | 1 |
| Kim, H | 1 |
| Mensour, M | 1 |
| Pineau, R | 1 |
| Sahai, V | 1 |
| Michaud, J | 1 |
| Hull, CJ | 1 |
| Jacobson, L | 1 |
| Cooper, GM | 1 |
| O'Connor, M | 1 |
| Mark, J | 1 |
| Harvey, J | 1 |
| Milgrom, P | 1 |
| Beirne, OR | 1 |
| Fiset, L | 1 |
| Weinstein, P | 1 |
| Tay, KM | 1 |
| Martin, M | 1 |
| Kanmura, Y | 1 |
| Hagihira, Y | 1 |
| Higashi, M | 1 |
| Yamashita, K | 1 |
| Sameshima, K | 1 |
| Toda, H | 1 |
| Yoshimura, N | 1 |
| Yaster, M | 1 |
| Koehler, RC | 1 |
| Traystman, RJ | 1 |
| Cheng, DC | 1 |
| Karski, J | 1 |
| Peniston, C | 1 |
| Asokumar, B | 1 |
| Raveendran, G | 1 |
| Carroll, J | 1 |
| Nierenberg, H | 1 |
| Roger, S | 1 |
| Mickle, D | 1 |
| Tong, J | 1 |
| Zelovitsky, J | 1 |
| David, T | 1 |
| Sandler, A | 1 |
| Luo, LK | 1 |
| Tong, SY | 1 |
| Liao, X | 1 |
| Deng, XM | 1 |
| An, G | 1 |
| Vaughn, PR | 1 |
| Townsend, SF | 1 |
| Thilo, EH | 1 |
| McKenzie, S | 1 |
| Moreland, S | 1 |
| Denver, KK | 1 |
| Ostermeier, AM | 1 |
| Roizen, MF | 1 |
| Hautkappe, M | 1 |
| Klock, PA | 1 |
| Klafta, JM | 1 |
| Cressey, DM | 1 |
| Claydon, P | 1 |
| Bhaskaran, NC | 1 |
| Reilly, CS | 2 |
| Waters, KA | 1 |
| McBrien, F | 1 |
| Stewart, P | 1 |
| Hinder, M | 1 |
| Wharton, S | 1 |
| Kugler, J | 1 |
| Grote, B | 1 |
| Laub, M | 1 |
| Doenicke, A | 1 |
| Dick, E | 1 |
| Hug, CC | 1 |
| Murphy, MR | 1 |
| Lui, PW | 1 |
| Lu, PK | 1 |
| Hsieh, JC | 1 |
| Lee, TY | 1 |
| Weisman, SJ | 1 |
| Schechter, NL | 1 |
| Smart, NG | 1 |
| Gibson, P | 1 |
| Murrell, D | 1 |
| Gill, SS | 1 |
| O'Donohoe, B | 1 |
| Paech, M | 1 |
| Blankstein, KC | 1 |
| Anderson, JA | 1 |
| Bailey, PL | 1 |
| Pace, NL | 2 |
| Ashburn, MA | 1 |
| Moll, JW | 1 |
| East, KA | 1 |
| Stanley, TH | 2 |
| Yeadon, M | 1 |
| Kitchen, I | 1 |
| Doolittle, GM | 1 |
| Greiner, AS | 1 |
| Overweg-van Kints, J | 1 |
| Blackburn, CL | 1 |
| Groen, HD | 1 |
| Stricker, BH | 1 |
| Chang, J | 1 |
| Fish, KJ | 1 |
| Campbell, RL | 1 |
| Villacèque, E | 1 |
| Caussade, D | 1 |
| Mengelle, F | 1 |
| Ducassé, JL | 1 |
| Virenque, C | 1 |
| Cartwright, DP | 1 |
| Giese, JL | 1 |
| Stockham, RJ | 1 |
| Nelissen, RH | 1 |
| Billmire, DA | 1 |
| Neale, HW | 1 |
| Gregory, RO | 1 |
| Heissen, E | 1 |
| Teske, HJ | 1 |
| Haller, J | 1 |
| Chopdar, A | 1 |
| Gordon, M | 1 |
| Sellars, S | 1 |
| Benzer, H | 1 |
| Kunz, H | 1 |
| Lempert, J | 1 |
| Mayrhofer, O | 1 |
| Muhar, F | 1 |
Clinical Trials (7)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists - a Study in Opioid naïve Individuals and Chronic Opioid Users Under Real-life Conditions[NCT05338632] | Phase 1 | 24 participants (Anticipated) | Interventional | 2022-06-24 | Recruiting | ||
| "A Less-rapid Sequence Anesthetic Induction/Intubation Sequence? Does Apneic Oxygenation by Means of an Oxygenating Laryngoscope Blade Prolong the Duration of Apnea Without Desaturation in Paralyzed Non-obese and Morbidly Obese Patients?"[NCT02943629] | 0 participants (Actual) | Interventional | 2016-11-30 | Withdrawn (stopped due to Lack of feasibility) | |||
| [NCT02039453] | 160 participants (Anticipated) | Interventional | 2013-09-30 | Recruiting | |||
| A Psychomotor Recuperation Study After Deep Sedation for Colonoscopy Between Target Controlled and Manual Titration of Propofol.[NCT02314559] | Phase 4 | 164 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Postoperative Management of Obstructive Sleep Apnea With CPAP vs. an Autoadjusting CPAP Device: a Randomized Controlled Single Center Trial[NCT00588848] | 11 participants (Actual) | Interventional | 2008-01-31 | Terminated (stopped due to Difficulty with enrollment) | |||
| The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800] | Phase 3 | 6 participants (Actual) | Interventional | 2016-05-20 | Terminated (stopped due to Difficulties with recruitment) | ||
| Dex vs Dazzle: Dexmedetomidine vs Midazolam for Intraoperative Sedation[NCT02878837] | Phase 4 | 120 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Apnea-Hypopnea Index (AHI)
Events are defined as apneas and hypopneas. AHI values are typically categorized as 5-14.9 events/hr = mild; 15-29.9 events/hr = moderate; and >= 30 events/hr = severe (NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.
| Intervention | events per hour (Mean) |
|---|---|
| AUTOCPAP | 2.1 |
| CPAP | 1.2 |
Cardiopulmonary Complications
Predefined cardiopulmonary complications: Myocardial Infarction, Arrhythmia, new onset Heart Failure, Stroke (NCT00588848)
Timeframe: 72 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Autoadjusting CPAP (VPAP Auto) | 0 |
| CPAP Arm (Usual Care) | 0 |
Sleep Related Hypoxemia
(NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.
| Intervention | Percentage of time < 90% saturation (Mean) |
|---|---|
| AUTOCPAP | 10.5 |
| CPAP | 7.1 |
Reviews
7 reviews available for fentanyl and Apnea
| Article | Year |
|---|---|
Non-opioid analgesics for procedural pain in neonates.
Topics: Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Body Wei | 2023 |
Opioids for procedural pain in neonates.
Topics: Analgesics; Analgesics, Opioid; Apnea; Bradycardia; Fentanyl; Humans; Hypotension; Infant; Infant, N | 2023 |
Opioids for procedural pain in neonates.
Topics: Analgesics; Analgesics, Opioid; Apnea; Bradycardia; Fentanyl; Humans; Hypotension; Infant, Newborn; | 2023 |
Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants.
Topics: Analgesics; Anesthetics, Local; Apnea; Bradycardia; Fentanyl; Humans; Hypnotics and Sedatives; Infan | 2023 |
Anaesthetic and sedative agents used for electrical cardioversion.
Topics: Anesthetics; Apnea; Diazepam; Electric Countershock; Etomidate; Fentanyl; Humans; Hypnotics and Seda | 2015 |
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy | 2005 |
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy | 2005 |
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy | 2005 |
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy | 2005 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Trials
25 trials available for fentanyl and Apnea
| Article | Year |
|---|---|
Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial.
Topics: Apnea; Colonoscopy; Dexmedetomidine; Double-Blind Method; Fentanyl; Humans; Hypnotics and Sedatives; | 2022 |
Effect of intravenous fentanyl on cough reflex and quality of endotracheal intubation in cats.
Topics: Anesthesia, General; Anesthetics, Intravenous; Animals; Apnea; Cat Diseases; Cats; Cough; Dexmedetom | 2023 |
Effects of fentanyl administration before induction of anesthesia and placement of the Laryngeal Mask Airway: a randomized, placebo-controlled trial.
Topics: Adult; Analgesics, Opioid; Anesthesia; Apnea; Double-Blind Method; Female; Fentanyl; Humans; Larynge | 2014 |
Intravenous remifentanil and propofol for gastroscopy.
Topics: Adult; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Intravenous; Apnea; Cognition | 2008 |
Fentanyl dose for the insertion of Classic Laryngeal Mask Airways in non-paralysed patients induced with propofol 2.5 mg/kg.
Topics: Adult; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Apnea; Female; Fentany | 2010 |
Effect of suxamethonium vs rocuronium on onset of oxygen desaturation during apnoea following rapid sequence induction.
Topics: Adult; Androstanols; Anesthesia, General; Anesthetics, Intravenous; Anesthetics, Local; Apnea; Fasci | 2010 |
Remifentanil versus fentanyl for esophagogastroduodenoscopy in children.
Topics: Analgesics, Opioid; Apnea; Child; Endoscopy, Digestive System; Female; Fentanyl; Hemodynamics; Human | 2010 |
Moderate sedation for elective upper endoscopy with balanced propofol versus fentanyl and midazolam alone: a randomized clinical trial.
Topics: Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Deep Sedation; Endoscopy, Digesti | 2012 |
Comparison of propofol and sevoflurane for laryngeal mask airway insertion.
Topics: Adult; Analysis of Variance; Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Blood Pressur | 2003 |
Propofol for deep procedural sedation in the ED.
Topics: Adolescent; Adult; Analgesics, Opioid; Apnea; Conscious Sedation; Dose-Response Relationship, Drug; | 2005 |
Opioid-induced respiratory effects: new data on buprenorphine.
Topics: Analgesics, Opioid; Apnea; Buprenorphine; Dose-Response Relationship, Drug; Double-Blind Method; Fen | 2006 |
Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children.
Topics: Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation; Apnea; Blood Pressure; Child; Chil | 2006 |
A clinical trial of alfentanil as an adjuvant for short anaesthetic procedures.
Topics: Abortion, Induced; Adjuvants, Anesthesia; Adolescent; Adult; Aged; Alfentanil; Anesthesia, Intraveno | 1983 |
Effect of alfentanil and fentanyl on recovery from brief anaesthesia.
Topics: Adolescent; Adult; Alfentanil; Anesthesia, General; Anesthesia, Intravenous; Apnea; Female; Fentanyl | 1983 |
The safety and efficacy of outpatient midazolam intravenous sedation for oral surgery with and without fentanyl.
Topics: Adolescent; Adult; Anesthesia, Dental; Apnea; Chi-Square Distribution; Conscious Sedation; Dental An | 1993 |
Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial.
Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Catecholamines; | 1996 |
Study of the safe threshold of apneic period in children during anesthesia induction.
Topics: Age Factors; Anesthesia, Intravenous; Anesthetics, Intravenous; Apnea; Body Height; Body Weight; Bra | 1996 |
Comparison of continuous infusion of fentanyl to bolus dosing in neonates after surgery.
Topics: Analgesics, Opioid; Apnea; Double-Blind Method; Fentanyl; Humans; Hydrocortisone; Infant, Newborn; I | 1996 |
Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aging; Analysis of Variance; Anesthetics, Intravenou | 2001 |
Effects of OSA, inhalational anesthesia, and fentanyl on the airway and ventilation of children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Apnea; Carbon Dioxide; Child; Child, Preschool; Drug Sy | 2002 |
[The hypnotic effect of fentanyl and sulfentanil. An electro-encephalographic comparison (author's transl)].
Topics: Adult; Anilides; Apnea; Blood Pressure; Dose-Response Relationship, Drug; Electroencephalography; Fe | 1977 |
Changes in oxygen saturation following propofol induction of anaesthesia at different rates in the elderly.
Topics: Aged; Anesthesia, Intravenous; Apnea; Fentanyl; Humans; Oximetry; Oxygen; Oxygen Consumption; Propof | 1991 |
A double-blind comparison of low-dose intravenous ketamine and methohexital in adults.
Topics: Adolescent; Adult; Amnesia; Anesthesia, Dental; Apnea; Carbon Dioxide; Double-Blind Method; Female; | 1991 |
Recovery after anaesthesia with alfentanil or halothane.
Topics: Adult; Aged; Alfentanil; Anesthesia Recovery Period; Apnea; Clinical Trials as Topic; Dose-Response | 1985 |
Etomidate versus thiopental for induction of anesthesia.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anesthesia, General; Anesthesia, Inhalation; Anesthes | 1985 |
Other Studies
35 other studies available for fentanyl and Apnea
| Article | Year |
|---|---|
Fentanyl effects on respiratory neuron activity in the dorsolateral pons.
Topics: Analgesics, Opioid; Animals; Apnea; Fentanyl; Naloxone; Neurons; Pons; Rats; Respiration | 2022 |
Kölliker-Fuse/Parabrachial complex mu opioid receptors contribute to fentanyl-induced apnea and respiratory rate depression.
Topics: Analgesics, Opioid; Animals; Apnea; Female; Fentanyl; Kolliker-Fuse Nucleus; Male; Narcotic Antagoni | 2020 |
Tolerance to Opioid-Induced Respiratory Depression in Chronic High-Dose Opioid Users: A Model-Based Comparison With Opioid-Naïve Individuals.
Topics: Adult; Analgesics, Opioid; Apnea; Computer Simulation; Drug Tolerance; Female; Fentanyl; Humans; Inf | 2021 |
[A case of tracheal intubation for apnea with epidural opioid in recovery room after operation under general anesthesia].
Topics: Adjuvants, Anesthesia; Adnexa Uteri; Aged; Anesthesia, General; Apnea; Female; Fentanyl; Humans; Int | 2013 |
Opioid intoxications involving butyrfentanyl, 4-fluorobutyrfentanyl, and fentanyl from the Swedish STRIDA project.
Topics: Adult; Analgesics, Opioid; Apnea; Chromatography, Liquid; Dose-Response Relationship, Drug; Emergenc | 2015 |
Propofol-fentanyl interaction in Beagles - Apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Animals; Apnea; Dogs; Female; Fentanyl; Hypnotics and | 2017 |
Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats.
Topics: Analgesics, Opioid; Animals; Apnea; Brain Stem; Fentanyl; Heart; Injections, Intraperitoneal; Inject | 2009 |
Comparison of desaturation and resaturation response times between transmission and reflectance pulse oximeters.
Topics: Adult; Androstanols; Anesthetics, Intravenous; Apnea; Breast; Equipment Design; Female; Fentanyl; Fi | 2010 |
Opioid toxicity as a result of oral/transmucosal administration of transdermal fentanyl patch.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Apnea; Coma; Fentanyl; G | 2009 |
A novel technique for monitoring of fast variations in brain oxygen tension using an uncoated fluorescence quenching probe (Foxy AL-300).
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Apnea; Blood Gas Analysis; Calibration; | 2011 |
Toxic leukoencephalopathy due to transdermal fentanyl overdose.
Topics: Accidents, Home; Administration, Cutaneous; Apnea; Child, Preschool; Coma; Decerebrate State; Delaye | 2011 |
8-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT1A receptors in the nucleus tractus solitarius.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apnea; Blood Pressure; Fentanyl; Heart Rate; Male; | 2012 |
Contribution of central μ-receptors to switching pulmonary C-fibers-mediated rapid shallow breathing into an apnea by fentanyl in anesthetized rats.
Topics: Analgesics, Opioid; Animals; Apnea; Fentanyl; Lung; Male; Nerve Fibers, Unmyelinated; Rats; Rats, Sp | 2012 |
Dopamine1 receptor agonists reverse opioid respiratory network depression, increase CO2 reactivity.
Topics: Action Potentials; Analgesics, Opioid; Analysis of Variance; Animals; Apnea; Carbon Dioxide; Cats; D | 2004 |
Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS).
Topics: Adolescent; Adult; Age Factors; Aged; Apnea; Blood Gas Monitoring, Transcutaneous; Bradycardia; Cana | 2006 |
[Anesthetic management of cesarean section in a patient with dilated cardiomyopathy].
Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Apnea; Cardiomyopathy, Dilated; Cesarean Sectio | 1995 |
Interaction of fentanyl and nitrous oxide on peripheral and cerebral hemodynamics in newborn lambs.
Topics: Anesthesia, General; Animals; Animals, Newborn; Apnea; Cerebrovascular Circulation; Drug Interaction | 1994 |
Fentanyl disposition in cerebrospinal fluid and plasma and its relationship to ventilatory depression in the dog.
Topics: Animals; Apnea; Carbon Dioxide; Dogs; Dose-Response Relationship, Drug; Fentanyl; Lung; Tidal Volume | 1979 |
Post-operative muscle rigidity in an infant.
Topics: Anesthesia, Intravenous; Apnea; Drug Interactions; Fentanyl; Humans; Hydrocephalus; Infant; Male; Mu | 1992 |
Therapeutic orphans.
Topics: Anesthesia, Intravenous; Apnea; Bone Marrow Examination; Child; Fentanyl; Humans; Midazolam | 1992 |
Epidural LA/opioid.
Topics: Analgesia, Epidural; Apnea; Bupivacaine; Fentanyl; Humans; Lumbar Vertebrae; Respiratory Insufficien | 1991 |
Complications of epidural analgesia.
Topics: Adult; Analgesia, Epidural; Apnea; Bupivacaine; Child; Fentanyl; Humans; Infant; Respiratory Insuffi | 1991 |
Epidural bupivacaine-fentanyl infusions.
Topics: Analgesia, Epidural; Apnea; Bupivacaine; Fentanyl; Humans; Respiratory Insufficiency | 1991 |
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi | 1990 |
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi | 1990 |
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi | 1990 |
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi | 1990 |
Multiple opioid receptors mediate the respiratory depressant effects of fentanyl-like drugs in the rat.
Topics: Alfentanil; Anesthesia; Animals; Apnea; Blood Gas Analysis; Fentanyl; Hemodynamics; In Vitro Techniq | 1990 |
Anesthetic complications in an infant with hyperexplexia.
Topics: Anesthesia; Apnea; Fentanyl; Hernia, Inguinal; Humans; Infant; Intraoperative Complications; Male; M | 1990 |
[Apnea following epidural administration of sufentanil].
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Apnea; Female; Fentanyl; Humans; Mi | 1989 |
Acute respiratory arrest and rigidity after anesthesia with sufentanil: a case report.
Topics: Acute Disease; Adult; Anesthesia, General; Anesthetics; Apnea; Coma; Fentanyl; Humans; Male; Muscle | 1985 |
Prevention of complications associated with intravenous sedation and general anesthesia.
Topics: Adult; Anesthesia, Dental; Anesthesia, General; Anesthesia, Intravenous; Anesthetics; Apnea; Arrhyth | 1986 |
[Propofol in scheduled orthopedic surgery].
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics; Apnea; Drug Evaluation; Fem | 1987 |
Use of i.v. fentanyl in the outpatient treatment of pediatric facial trauma.
Topics: Ambulatory Surgical Procedures; Apnea; Child; Child, Preschool; Emergencies; Facial Injuries; Fentan | 1985 |
[Advantages of neuroleptic analgesia in arteriographic studies (experiences with Thalamonal)].
Topics: Adolescent; Adult; Aged; Angiography; Apnea; Benperidol; Blood Pressure; Drug Eruptions; Drug Hypers | 1971 |
Sedation for cataract surgery. Comparison of Carbrital and neuroleptanalgesia.
Topics: Aged; Apnea; Arrhythmias, Cardiac; Benperidol; Butyrates; Cataract Extraction; Fentanyl; Humans; Hyp | 1970 |
Anaesthesia for microsurgery of the larynx. General anaesthesia combined with neuroleptanalgesia.
Topics: Anesthesia, General; Apnea; Benperidol; Blood Pressure; Child; Fentanyl; Halothane; Humans; Larynx; | 1971 |
[On the significance of oxygen supply in drug induced central respiratory depression].
Topics: Animals; Apnea; Carbon Dioxide; Fentanyl; Hypercapnia; Hypoxia; Neuroleptanalgesia; Oxygen Consumpti | 1967 |