Page last updated: 2024-10-27

fentanyl and Apnea

fentanyl has been researched along with Apnea in 67 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Apnea: A transient absence of spontaneous respiration.

Research Excerpts

ExcerptRelevanceReference
"In cats sedated with dexmedetomidine, fentanyl could be considered to reduce the alfaxalone induction dose, cough reflex and laryngeal response to ETI and to improve the overall quality of ETI."9.69Effect of intravenous fentanyl on cough reflex and quality of endotracheal intubation in cats. ( Martín Bellido, V; Martínez I Ferré, B; McDonald, H; Vettorato, E, 2023)
"Apnea occurrence and duration of manual ventilation, as well as frequency and severity of movement, coughing, breath holding, and laryngospasm were recorded."9.19Effects of fentanyl administration before induction of anesthesia and placement of the Laryngeal Mask Airway: a randomized, placebo-controlled trial. ( Gasanova, I; Joshi, GP; Kamali, A; Meng, J; Rosero, E, 2014)
" Identifying mechanisms to counter progression to fatal respiratory apnea during opioid overdose is desirable, but difficult to study in vivo."7.96Kölliker-Fuse/Parabrachial complex mu opioid receptors contribute to fentanyl-induced apnea and respiratory rate depression. ( Levitt, ES; Saunders, SE, 2020)
"The objective of this study was to characterize the propofol-fentanyl interaction in Beagles for four pharmacodynamic endpoints: apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation."7.85Propofol-fentanyl interaction in Beagles - Apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation. ( Iizuka, T; Kanazawa, H; Masui, K; Miyabe-Nishiwaki, T; Nishimura, R, 2017)
" We intubated the patient immediately for apnea that occurred after extubation."7.79[A case of tracheal intubation for apnea with epidural opioid in recovery room after operation under general anesthesia]. ( Ouchi, K; Sugiyama, K; Uno, H, 2013)
"Our previous study has shown that activating peripheral μ-receptors is necessary for switching the bronchopulmonary C-fibers (PCFs)-mediated rapid shallow breathing (RSB) into an apnea by systemic administration of fentanyl."7.78Contribution of central μ-receptors to switching pulmonary C-fibers-mediated rapid shallow breathing into an apnea by fentanyl in anesthetized rats. ( Xu, F; Zhang, C; Zhang, Z; Zhuang, J, 2012)
" Specifically, to determine if the ampakine CX717, which has been proven metabolically stable and safe for human use, can prevent and rescue from severe fentanyl-induced apnea."7.75Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats. ( Ding, X; Funk, GD; Greer, JJ; Ren, J, 2009)
" The incidence of hypoxemia (oxyhemoglobin saturation less than 90%) and apnea (no spontaneous respiratory effort for 15 s) and the ventilatory response to carbon dioxide were evaluated."7.68Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. ( Ashburn, MA; Bailey, PL; East, KA; Moll, JW; Pace, NL; Stanley, TH, 1990)
"In cats sedated with dexmedetomidine, fentanyl could be considered to reduce the alfaxalone induction dose, cough reflex and laryngeal response to ETI and to improve the overall quality of ETI."5.69Effect of intravenous fentanyl on cough reflex and quality of endotracheal intubation in cats. ( Martín Bellido, V; Martínez I Ferré, B; McDonald, H; Vettorato, E, 2023)
" Complications including apnea, hypotension, hypoxia, nausea, and vomiting, along with gastroenterologist satisfaction and patients' pain score (based on Wong-Baker faces pain assessment scale), were recorded by a checklist."5.51Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial. ( Aghaali, M; Ahmadpour, S; Alemi, F; Aminnejad, R; Hormati, A; Hormati, M; Sabouri, SM; Saeidi, M; Shafiee, H, 2022)
" Our main outcomes were pain assessed during the procedure and up to 10 minutes after the procedure with a validated scale; episodes of bradycardia; episodes of apnea; and hypotension requiring medical therapy."5.41Non-opioid analgesics for procedural pain in neonates. ( Bruschettini, M; Persad, E; Pizarro, AB, 2023)
" Opioids may result in an increase in episodes of apnea."5.41Opioids for procedural pain in neonates. ( Borys, F; Bruschettini, M; Kinoshita, M; Olsson, E, 2023)
" The evidence is very uncertain about the effect of opioids on episodes of bradycardia, hypotension or severe apnea."5.41Opioids for procedural pain in neonates. ( Borys, F; Bruschettini, M; Kinoshita, M; Olsson, E, 2023)
" Our main outcomes were successful LP on first attempt, total number of LP attempts, episodes of bradycardia, pain assessed with validated scales, episodes of desaturation, number of episodes of apnea, and number of infants with one or more episodes of apnea."5.41Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants. ( Bruschettini, M; Hedayati, E; Olsson, E; Pessano, S; Romantsik, O, 2023)
"Apnea occurrence and duration of manual ventilation, as well as frequency and severity of movement, coughing, breath holding, and laryngospasm were recorded."5.19Effects of fentanyl administration before induction of anesthesia and placement of the Laryngeal Mask Airway: a randomized, placebo-controlled trial. ( Gasanova, I; Joshi, GP; Kamali, A; Meng, J; Rosero, E, 2014)
" Apnea periods >20 seconds and decreases in SaO2 <90% occurred more frequently in group R (31."5.14Remifentanil versus fentanyl for esophagogastroduodenoscopy in children. ( Hirsh, I; Lerner, A; Pacht, A; Pizov, R; Reuveni, A; Segol, O; Shnaider, I, 2010)
" Frequency of apnea was significantly higher in the remifentanil group (P < 0."5.13Intravenous remifentanil and propofol for gastroscopy. ( Liu, J; Si, YY; Wang, X; Wu, JC; Xu, ZY; Xue, FS; Zuo, YX, 2008)
"The incidence of typical airway irritation events was lower with fentanyl than with saline (cough, 2."5.12Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children. ( Kim, C; Kim, H; Kim, S; Lee, J; Oh, Y; Park, H, 2006)
"4%), including hypotension in 5, hypoxemia in 7, and apnea in 5."5.11Propofol for deep procedural sedation in the ED. ( Baire, M; Frazee, BW; Lowery, D; Park, RS, 2005)
"To assess effects of anesthesia and opioids, we studied 13 children with obstructive sleep apnea (OSA, age 4."5.10Effects of OSA, inhalational anesthesia, and fentanyl on the airway and ventilation of children. ( Hinder, M; McBrien, F; Stewart, P; Waters, KA; Wharton, S, 2002)
"In phase 1, apnea occurred in eight of nine B patients (89%) compared with one of seven C patients (14%; P < ."5.08Comparison of continuous infusion of fentanyl to bolus dosing in neonates after surgery. ( Denver, KK; McKenzie, S; Moreland, S; Thilo, EH; Townsend, SF; Vaughn, PR, 1996)
" Despite the same duration of preoxygenation, younger children were more susceptible than elder ones to the risk of hypoxemia during apnea."5.08Study of the safe threshold of apneic period in children during anesthesia induction. ( An, G; Deng, XM; Liao, X; Luo, LK; Tong, SY; Xue, FS, 1996)
" Postextubation apnea characteristics were similar between the groups."5.08Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial. ( Asokumar, B; Carroll, J; Cheng, DC; David, T; Karski, J; Mickle, D; Nierenberg, H; Peniston, C; Raveendran, G; Roger, S; Sandler, A; Tong, J; Zelovitsky, J, 1996)
" Low-dose intravenous ketamine as the primary anesthetic following premedication with fentanyl and midazolam, and in conjunction with nitrous oxide, appeared to produce less hypoxia, hypercarbia, and apnea than when methohexital was used."5.07A double-blind comparison of low-dose intravenous ketamine and methohexital in adults. ( Anderson, JA; Blankstein, KC, 1991)
" While these results are consistent with those for apnea, contingency analyses of the oxygen saturation and EtCO2 results were not statistically significant."5.07The safety and efficacy of outpatient midazolam intravenous sedation for oral surgery with and without fentanyl. ( Beirne, OR; Fiset, L; Martin, M; Milgrom, P; Tay, KM; Weinstein, P, 1993)
" Data from the D and C patients was treated separately from that for TOP and ERPC patients; marked differences were found in incremental requirements for methohexitone, the frequency of apnea, the observed respiratory rates, and the mean arterial pressure."5.05A clinical trial of alfentanil as an adjuvant for short anaesthetic procedures. ( Hull, CJ; Jacobson, L, 1983)
" Patients in whom anesthesia was induced with etomidate had a greater incidence of pain on injection and myoclonus and a lesser incidence of apnea than patients in whom anesthesia was induced with thiopental."5.05Etomidate versus thiopental for induction of anesthesia. ( Giese, JL; Nelissen, RH; Pace, NL; Stanley, TH; Stockham, RJ, 1985)
" The following 4 cardiopulmonary complications were assessed: hypoxia, hypotension, arrhythmias, and apnea."4.82Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis. ( Khandwala, F; Lopez, R; Qadeer, MA; Vargo, JJ; Zuccaro, G, 2005)
" Inspiratory neurons and a subset of inspiratory/expiratory phase-spanning neurons were either silenced or had reduced firing frequency during fentanyl-induced apnea, which was reversed upon administration of naloxone."4.12Fentanyl effects on respiratory neuron activity in the dorsolateral pons. ( Baekey, DM; Levitt, ES; Saunders, SE, 2022)
" Clinical features included typical opioid symptoms such as unconsciousness, respiratory depression, and apnea."3.81Opioid intoxications involving butyrfentanyl, 4-fluorobutyrfentanyl, and fentanyl from the Swedish STRIDA project. ( Bäckberg, M; Beck, O; Helander, A; Jönsson, KH, 2015)
" We intubated the patient immediately for apnea that occurred after extubation."3.79[A case of tracheal intubation for apnea with epidural opioid in recovery room after operation under general anesthesia]. ( Ouchi, K; Sugiyama, K; Uno, H, 2013)
"Intravenous bolus injection of morphine causes a vagal-mediated brief apnea (∼3 s), while continuous injection, via action upon central μ-opioid receptor (MOR), arrests ventilation (>20 s) that is eliminated by stimulating central 5-hydroxytryptamine 1A receptors (5HT(1A)Rs)."3.788-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT1A receptors in the nucleus tractus solitarius. ( Xu, F; Zhang, C; Zhang, Z; Zhuang, J, 2012)
" We report a case of a 19-month-old girl who presented in coma and who was later found to have a fentanyl patch adhered to her back."3.77Toxic leukoencephalopathy due to transdermal fentanyl overdose. ( Bradin, SA; Foy, L; Seeyave, DM, 2011)
"Individual Foxy-paO(2), Foxy-ptiO(2), and Licox-ptiO(2) courses were related to episodes of apnea."3.77A novel technique for monitoring of fast variations in brain oxygen tension using an uncoated fluorescence quenching probe (Foxy AL-300). ( Boehme, S; David, M; Engelhard, K; Hartmann, EK; Klein, KU; Markstaller, K; Szczyrba, M, 2011)
"The desaturation response time of SpO(2) to 95% after apnea was 82."3.76Comparison of desaturation and resaturation response times between transmission and reflectance pulse oximeters. ( Ahn, HJ; Choi, SJ; Kang, JG; Kang, JY; Kim, CS; Kim, JA; Kim, JK; Sim, WS; Yang, MK, 2010)
" Specifically, to determine if the ampakine CX717, which has been proven metabolically stable and safe for human use, can prevent and rescue from severe fentanyl-induced apnea."3.75Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats. ( Ding, X; Funk, GD; Greer, JJ; Ren, J, 2009)
" The adverse event (AE) rate was 18% and included apnea (10%), inadequate sedation (3%), bradycardia (2%), desaturation (1%), hypotension (1%) and bag-valve-mask use (1%)."3.73Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS). ( Mensour, M; Michaud, J; Pineau, R; Sahai, V, 2006)
" They also increased reactivity to CO(2) by lowering the phrenic nerve apnea threshold and shifting the phrenic nerve-CO(2) response curve to lower et(CO(2)) levels."3.72Dopamine1 receptor agonists reverse opioid respiratory network depression, increase CO2 reactivity. ( Lalley, PM, 2004)
" Additionally, fentanyl produced immediate apnea necessitating tracheal intubation and mechanical ventilation."3.69Interaction of fentanyl and nitrous oxide on peripheral and cerebral hemodynamics in newborn lambs. ( Koehler, RC; Traystman, RJ; Yaster, M, 1994)
" The incidence of hypoxemia (oxyhemoglobin saturation less than 90%) and apnea (no spontaneous respiratory effort for 15 s) and the ventilatory response to carbon dioxide were evaluated."3.68Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. ( Ashburn, MA; Bailey, PL; East, KA; Moll, JW; Pace, NL; Stanley, TH, 1990)
" The potency ratios of the fentanyl drugs to produce apnea and depress minute volume were dissimilar."3.68Multiple opioid receptors mediate the respiratory depressant effects of fentanyl-like drugs in the rat. ( Kitchen, I; Yeadon, M, 1990)
" The major possible complication is that of apnea, which requires that resuscitation equipment be available."3.67Use of i.v. fentanyl in the outpatient treatment of pediatric facial trauma. ( Billmire, DA; Gregory, RO; Neale, HW, 1985)
"Buprenorphine causes limited respiratory depression with a ceiling effect at higher doses, while fentanyl causes dose-dependent respiratory depression with apnoea at high dose levels."2.72Opioid-induced respiratory effects: new data on buprenorphine. ( Dahan, A, 2006)
"Sevoflurane is an alternative to propofol for induction of anaesthesia and has a lower incidence of apnoea."2.71Comparison of propofol and sevoflurane for laryngeal mask airway insertion. ( Coskuner, I; Demirel, CB; Huseyinoglu, UA; Kati, I; Silay, E; Yagmur, C, 2003)
"Midazolam pretreatment was associated with a significant reduction in propofol dose requirement in both younger and older patients."2.70Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults. ( Bhaskaran, NC; Claydon, P; Cressey, DM; Reilly, CS, 2001)
" With a dosage of ratio of 1:10, i."2.64[The hypnotic effect of fentanyl and sulfentanil. An electro-encephalographic comparison (author's transl)]. ( Dick, E; Doenicke, A; Grote, B; Kugler, J; Laub, M, 1977)

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-199015 (22.39)18.7374
1990's17 (25.37)18.2507
2000's12 (17.91)29.6817
2010's14 (20.90)24.3611
2020's9 (13.43)2.80

Authors

AuthorsStudies
Aminnejad, R1
Hormati, A1
Shafiee, H1
Alemi, F1
Hormati, M1
Saeidi, M1
Ahmadpour, S1
Sabouri, SM1
Aghaali, M1
Saunders, SE2
Baekey, DM1
Levitt, ES2
Persad, E1
Pizarro, AB1
Bruschettini, M4
Kinoshita, M2
Olsson, E3
Borys, F2
Martín Bellido, V1
Martínez I Ferré, B1
McDonald, H1
Vettorato, E1
Pessano, S1
Romantsik, O1
Hedayati, E1
Algera, MH1
Olofsen, E1
Moss, L1
Dobbins, RL1
Niesters, M1
van Velzen, M1
Groeneveld, GJ1
Heuberger, J1
Laffont, CM1
Dahan, A2
Ouchi, K1
Uno, H1
Sugiyama, K1
Joshi, GP1
Kamali, A1
Meng, J1
Rosero, E1
Gasanova, I1
Lewis, SR1
Nicholson, A1
Reed, SS1
Kenth, JJ1
Alderson, P1
Smith, AF1
Bäckberg, M1
Beck, O1
Jönsson, KH1
Helander, A1
Iizuka, T1
Masui, K1
Miyabe-Nishiwaki, T1
Kanazawa, H1
Nishimura, R1
Xu, ZY1
Wang, X1
Si, YY1
Wu, JC1
Zuo, YX1
Xue, FS2
Liu, J1
Ren, J1
Ding, X1
Funk, GD1
Greer, JJ1
Choi, SJ1
Ahn, HJ1
Yang, MK1
Kim, CS1
Sim, WS1
Kim, JA1
Kang, JG1
Kim, JK1
Kang, JY1
Bektas, F1
Eken, C1
Sayrac, V1
Tan, AS1
Wang, CY1
Taha, SK1
El-Khatib, MF1
Baraka, AS1
Haidar, YA1
Abdallah, FW1
Zbeidy, RA1
Siddik-Sayyid, SM1
Hirsh, I1
Lerner, A1
Shnaider, I1
Reuveni, A1
Pacht, A1
Segol, O1
Pizov, R1
Klein, KU1
Boehme, S1
Hartmann, EK1
Szczyrba, M1
David, M1
Markstaller, K1
Engelhard, K1
Foy, L1
Seeyave, DM1
Bradin, SA1
Levitzky, BE1
Lopez, R2
Dumot, JA1
Vargo, JJ2
Zhuang, J2
Zhang, Z2
Zhang, C2
Xu, F2
Kati, I1
Demirel, CB1
Huseyinoglu, UA1
Silay, E1
Yagmur, C1
Coskuner, I1
Lalley, PM1
Frazee, BW1
Park, RS1
Lowery, D1
Baire, M1
Qadeer, MA1
Khandwala, F1
Zuccaro, G1
Lee, J1
Oh, Y1
Kim, C1
Kim, S1
Park, H1
Kim, H1
Mensour, M1
Pineau, R1
Sahai, V1
Michaud, J1
Hull, CJ1
Jacobson, L1
Cooper, GM1
O'Connor, M1
Mark, J1
Harvey, J1
Milgrom, P1
Beirne, OR1
Fiset, L1
Weinstein, P1
Tay, KM1
Martin, M1
Kanmura, Y1
Hagihira, Y1
Higashi, M1
Yamashita, K1
Sameshima, K1
Toda, H1
Yoshimura, N1
Yaster, M1
Koehler, RC1
Traystman, RJ1
Cheng, DC1
Karski, J1
Peniston, C1
Asokumar, B1
Raveendran, G1
Carroll, J1
Nierenberg, H1
Roger, S1
Mickle, D1
Tong, J1
Zelovitsky, J1
David, T1
Sandler, A1
Luo, LK1
Tong, SY1
Liao, X1
Deng, XM1
An, G1
Vaughn, PR1
Townsend, SF1
Thilo, EH1
McKenzie, S1
Moreland, S1
Denver, KK1
Ostermeier, AM1
Roizen, MF1
Hautkappe, M1
Klock, PA1
Klafta, JM1
Cressey, DM1
Claydon, P1
Bhaskaran, NC1
Reilly, CS2
Waters, KA1
McBrien, F1
Stewart, P1
Hinder, M1
Wharton, S1
Kugler, J1
Grote, B1
Laub, M1
Doenicke, A1
Dick, E1
Hug, CC1
Murphy, MR1
Lui, PW1
Lu, PK1
Hsieh, JC1
Lee, TY1
Weisman, SJ1
Schechter, NL1
Smart, NG1
Gibson, P1
Murrell, D1
Gill, SS1
O'Donohoe, B1
Paech, M1
Blankstein, KC1
Anderson, JA1
Bailey, PL1
Pace, NL2
Ashburn, MA1
Moll, JW1
East, KA1
Stanley, TH2
Yeadon, M1
Kitchen, I1
Doolittle, GM1
Greiner, AS1
Overweg-van Kints, J1
Blackburn, CL1
Groen, HD1
Stricker, BH1
Chang, J1
Fish, KJ1
Campbell, RL1
Villacèque, E1
Caussade, D1
Mengelle, F1
Ducassé, JL1
Virenque, C1
Cartwright, DP1
Giese, JL1
Stockham, RJ1
Nelissen, RH1
Billmire, DA1
Neale, HW1
Gregory, RO1
Heissen, E1
Teske, HJ1
Haller, J1
Chopdar, A1
Gordon, M1
Sellars, S1
Benzer, H1
Kunz, H1
Lempert, J1
Mayrhofer, O1
Muhar, F1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Reversal of Opioid-induced Respiratory Depression With Opioid Antagonists - a Study in Opioid naïve Individuals and Chronic Opioid Users Under Real-life Conditions[NCT05338632]Phase 124 participants (Anticipated)Interventional2022-06-24Recruiting
"A Less-rapid Sequence Anesthetic Induction/Intubation Sequence? Does Apneic Oxygenation by Means of an Oxygenating Laryngoscope Blade Prolong the Duration of Apnea Without Desaturation in Paralyzed Non-obese and Morbidly Obese Patients?"[NCT02943629]0 participants (Actual)Interventional2016-11-30Withdrawn (stopped due to Lack of feasibility)
[NCT02039453]160 participants (Anticipated)Interventional2013-09-30Recruiting
A Psychomotor Recuperation Study After Deep Sedation for Colonoscopy Between Target Controlled and Manual Titration of Propofol.[NCT02314559]Phase 4164 participants (Actual)Interventional2015-02-28Completed
Postoperative Management of Obstructive Sleep Apnea With CPAP vs. an Autoadjusting CPAP Device: a Randomized Controlled Single Center Trial[NCT00588848]11 participants (Actual)Interventional2008-01-31Terminated (stopped due to Difficulty with enrollment)
The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800]Phase 36 participants (Actual)Interventional2016-05-20Terminated (stopped due to Difficulties with recruitment)
Dex vs Dazzle: Dexmedetomidine vs Midazolam for Intraoperative Sedation[NCT02878837]Phase 4120 participants (Actual)Interventional2016-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Apnea-Hypopnea Index (AHI)

Events are defined as apneas and hypopneas. AHI values are typically categorized as 5-14.9 events/hr = mild; 15-29.9 events/hr = moderate; and >= 30 events/hr = severe (NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.

Interventionevents per hour (Mean)
AUTOCPAP2.1
CPAP1.2

Cardiopulmonary Complications

Predefined cardiopulmonary complications: Myocardial Infarction, Arrhythmia, new onset Heart Failure, Stroke (NCT00588848)
Timeframe: 72 hours

InterventionParticipants (Count of Participants)
Autoadjusting CPAP (VPAP Auto)0
CPAP Arm (Usual Care)0

Sleep Related Hypoxemia

(NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.

InterventionPercentage of time < 90% saturation (Mean)
AUTOCPAP10.5
CPAP7.1

Reviews

7 reviews available for fentanyl and Apnea

ArticleYear
Non-opioid analgesics for procedural pain in neonates.
    The Cochrane database of systematic reviews, 2023, 04-04, Volume: 4

    Topics: Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Body Wei

2023
Opioids for procedural pain in neonates.
    The Cochrane database of systematic reviews, 2023, 04-05, Volume: 4

    Topics: Analgesics; Analgesics, Opioid; Apnea; Bradycardia; Fentanyl; Humans; Hypotension; Infant; Infant, N

2023
Opioids for procedural pain in neonates.
    The Cochrane database of systematic reviews, 2023, 06-23, Volume: 6

    Topics: Analgesics; Analgesics, Opioid; Apnea; Bradycardia; Fentanyl; Humans; Hypotension; Infant, Newborn;

2023
Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants.
    The Cochrane database of systematic reviews, 2023, 09-28, Volume: 9

    Topics: Analgesics; Anesthetics, Local; Apnea; Bradycardia; Fentanyl; Humans; Hypnotics and Sedatives; Infan

2023
Anaesthetic and sedative agents used for electrical cardioversion.
    The Cochrane database of systematic reviews, 2015, Mar-22, Issue:3

    Topics: Anesthetics; Apnea; Diazepam; Electric Countershock; Etomidate; Fentanyl; Humans; Hypnotics and Seda

2015
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe

1997
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe

1997
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe

1997
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe

1997

Trials

25 trials available for fentanyl and Apnea

ArticleYear
Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial.
    CNS & neurological disorders drug targets, 2022, Volume: 21, Issue:8

    Topics: Apnea; Colonoscopy; Dexmedetomidine; Double-Blind Method; Fentanyl; Humans; Hypnotics and Sedatives;

2022
Effect of intravenous fentanyl on cough reflex and quality of endotracheal intubation in cats.
    Veterinary anaesthesia and analgesia, 2023, Volume: 50, Issue:3

    Topics: Anesthesia, General; Anesthetics, Intravenous; Animals; Apnea; Cat Diseases; Cats; Cough; Dexmedetom

2023
Effects of fentanyl administration before induction of anesthesia and placement of the Laryngeal Mask Airway: a randomized, placebo-controlled trial.
    Journal of clinical anesthesia, 2014, Volume: 26, Issue:2

    Topics: Adult; Analgesics, Opioid; Anesthesia; Apnea; Double-Blind Method; Female; Fentanyl; Humans; Larynge

2014
Intravenous remifentanil and propofol for gastroscopy.
    Journal of clinical anesthesia, 2008, Volume: 20, Issue:5

    Topics: Adult; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Intravenous; Apnea; Cognition

2008
Fentanyl dose for the insertion of Classic Laryngeal Mask Airways in non-paralysed patients induced with propofol 2.5 mg/kg.
    Anaesthesia and intensive care, 2010, Volume: 38, Issue:1

    Topics: Adult; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Apnea; Female; Fentany

2010
Effect of suxamethonium vs rocuronium on onset of oxygen desaturation during apnoea following rapid sequence induction.
    Anaesthesia, 2010, Volume: 65, Issue:4

    Topics: Adult; Androstanols; Anesthesia, General; Anesthetics, Intravenous; Anesthetics, Local; Apnea; Fasci

2010
Remifentanil versus fentanyl for esophagogastroduodenoscopy in children.
    Journal of pediatric gastroenterology and nutrition, 2010, Volume: 51, Issue:5

    Topics: Analgesics, Opioid; Apnea; Child; Endoscopy, Digestive System; Female; Fentanyl; Hemodynamics; Human

2010
Moderate sedation for elective upper endoscopy with balanced propofol versus fentanyl and midazolam alone: a randomized clinical trial.
    Endoscopy, 2012, Volume: 44, Issue:1

    Topics: Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Deep Sedation; Endoscopy, Digesti

2012
Comparison of propofol and sevoflurane for laryngeal mask airway insertion.
    The Tohoku journal of experimental medicine, 2003, Volume: 200, Issue:3

    Topics: Adult; Analysis of Variance; Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Blood Pressur

2003
Propofol for deep procedural sedation in the ED.
    The American journal of emergency medicine, 2005, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Analgesics, Opioid; Apnea; Conscious Sedation; Dose-Response Relationship, Drug;

2005
Opioid-induced respiratory effects: new data on buprenorphine.
    Palliative medicine, 2006, Volume: 20 Suppl 1

    Topics: Analgesics, Opioid; Apnea; Buprenorphine; Dose-Response Relationship, Drug; Double-Blind Method; Fen

2006
Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children.
    Acta anaesthesiologica Scandinavica, 2006, Volume: 50, Issue:9

    Topics: Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation; Apnea; Blood Pressure; Child; Chil

2006
A clinical trial of alfentanil as an adjuvant for short anaesthetic procedures.
    British journal of anaesthesia, 1983, Volume: 55 Suppl 2

    Topics: Abortion, Induced; Adjuvants, Anesthesia; Adolescent; Adult; Aged; Alfentanil; Anesthesia, Intraveno

1983
Effect of alfentanil and fentanyl on recovery from brief anaesthesia.
    British journal of anaesthesia, 1983, Volume: 55 Suppl 2

    Topics: Adolescent; Adult; Alfentanil; Anesthesia, General; Anesthesia, Intravenous; Apnea; Female; Fentanyl

1983
The safety and efficacy of outpatient midazolam intravenous sedation for oral surgery with and without fentanyl.
    Anesthesia progress, 1993, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Anesthesia, Dental; Apnea; Chi-Square Distribution; Conscious Sedation; Dental An

1993
Morbidity outcome in early versus conventional tracheal extubation after coronary artery bypass grafting: a prospective randomized controlled trial.
    The Journal of thoracic and cardiovascular surgery, 1996, Volume: 112, Issue:3

    Topics: Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Apnea; Catecholamines;

1996
Study of the safe threshold of apneic period in children during anesthesia induction.
    Journal of clinical anesthesia, 1996, Volume: 8, Issue:7

    Topics: Age Factors; Anesthesia, Intravenous; Anesthetics, Intravenous; Apnea; Body Height; Body Weight; Bra

1996
Comparison of continuous infusion of fentanyl to bolus dosing in neonates after surgery.
    Journal of pediatric surgery, 1996, Volume: 31, Issue:12

    Topics: Analgesics, Opioid; Apnea; Double-Blind Method; Fentanyl; Humans; Hydrocortisone; Infant, Newborn; I

1996
Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults.
    Anaesthesia, 2001, Volume: 56, Issue:2

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aging; Analysis of Variance; Anesthetics, Intravenou

2001
Effects of OSA, inhalational anesthesia, and fentanyl on the airway and ventilation of children.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 92, Issue:5

    Topics: Analgesics, Opioid; Anesthetics, Inhalation; Apnea; Carbon Dioxide; Child; Child, Preschool; Drug Sy

2002
[The hypnotic effect of fentanyl and sulfentanil. An electro-encephalographic comparison (author's transl)].
    Der Anaesthesist, 1977, Volume: 26, Issue:7

    Topics: Adult; Anilides; Apnea; Blood Pressure; Dose-Response Relationship, Drug; Electroencephalography; Fe

1977
Changes in oxygen saturation following propofol induction of anaesthesia at different rates in the elderly.
    European journal of anaesthesiology, 1991, Volume: 8, Issue:6

    Topics: Aged; Anesthesia, Intravenous; Apnea; Fentanyl; Humans; Oximetry; Oxygen; Oxygen Consumption; Propof

1991
A double-blind comparison of low-dose intravenous ketamine and methohexital in adults.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1991, Volume: 49, Issue:5

    Topics: Adolescent; Adult; Amnesia; Anesthesia, Dental; Apnea; Carbon Dioxide; Double-Blind Method; Female;

1991
Recovery after anaesthesia with alfentanil or halothane.
    Canadian Anaesthetists' Society journal, 1985, Volume: 32, Issue:5

    Topics: Adult; Aged; Alfentanil; Anesthesia Recovery Period; Apnea; Clinical Trials as Topic; Dose-Response

1985
Etomidate versus thiopental for induction of anesthesia.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:9

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Anesthesia, General; Anesthesia, Inhalation; Anesthes

1985

Other Studies

35 other studies available for fentanyl and Apnea

ArticleYear
Fentanyl effects on respiratory neuron activity in the dorsolateral pons.
    Journal of neurophysiology, 2022, 11-01, Volume: 128, Issue:5

    Topics: Analgesics, Opioid; Animals; Apnea; Fentanyl; Naloxone; Neurons; Pons; Rats; Respiration

2022
Kölliker-Fuse/Parabrachial complex mu opioid receptors contribute to fentanyl-induced apnea and respiratory rate depression.
    Respiratory physiology & neurobiology, 2020, Volume: 275

    Topics: Analgesics, Opioid; Animals; Apnea; Female; Fentanyl; Kolliker-Fuse Nucleus; Male; Narcotic Antagoni

2020
Tolerance to Opioid-Induced Respiratory Depression in Chronic High-Dose Opioid Users: A Model-Based Comparison With Opioid-Naïve Individuals.
    Clinical pharmacology and therapeutics, 2021, Volume: 109, Issue:3

    Topics: Adult; Analgesics, Opioid; Apnea; Computer Simulation; Drug Tolerance; Female; Fentanyl; Humans; Inf

2021
[A case of tracheal intubation for apnea with epidural opioid in recovery room after operation under general anesthesia].
    Masui. The Japanese journal of anesthesiology, 2013, Volume: 62, Issue:10

    Topics: Adjuvants, Anesthesia; Adnexa Uteri; Aged; Anesthesia, General; Apnea; Female; Fentanyl; Humans; Int

2013
Opioid intoxications involving butyrfentanyl, 4-fluorobutyrfentanyl, and fentanyl from the Swedish STRIDA project.
    Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:7

    Topics: Adult; Analgesics, Opioid; Apnea; Chromatography, Liquid; Dose-Response Relationship, Drug; Emergenc

2015
Propofol-fentanyl interaction in Beagles - Apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation.
    Research in veterinary science, 2017, Volume: 115

    Topics: Analgesics, Opioid; Anesthetics, Intravenous; Animals; Apnea; Dogs; Female; Fentanyl; Hypnotics and

2017
Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats.
    Anesthesiology, 2009, Volume: 110, Issue:6

    Topics: Analgesics, Opioid; Animals; Apnea; Brain Stem; Fentanyl; Heart; Injections, Intraperitoneal; Inject

2009
Comparison of desaturation and resaturation response times between transmission and reflectance pulse oximeters.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2

    Topics: Adult; Androstanols; Anesthetics, Intravenous; Apnea; Breast; Equipment Design; Female; Fentanyl; Fi

2010
Opioid toxicity as a result of oral/transmucosal administration of transdermal fentanyl patch.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2009, Volume: 16, Issue:6

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Apnea; Coma; Fentanyl; G

2009
A novel technique for monitoring of fast variations in brain oxygen tension using an uncoated fluorescence quenching probe (Foxy AL-300).
    Journal of neurosurgical anesthesiology, 2011, Volume: 23, Issue:4

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Apnea; Blood Gas Analysis; Calibration;

2011
Toxic leukoencephalopathy due to transdermal fentanyl overdose.
    Pediatric emergency care, 2011, Volume: 27, Issue:9

    Topics: Accidents, Home; Administration, Cutaneous; Apnea; Child, Preschool; Coma; Decerebrate State; Delaye

2011
8-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT1A receptors in the nucleus tractus solitarius.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Aug-15, Volume: 303, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apnea; Blood Pressure; Fentanyl; Heart Rate; Male;

2012
Contribution of central μ-receptors to switching pulmonary C-fibers-mediated rapid shallow breathing into an apnea by fentanyl in anesthetized rats.
    Brain research, 2012, Aug-21, Volume: 1469

    Topics: Analgesics, Opioid; Animals; Apnea; Fentanyl; Lung; Male; Nerve Fibers, Unmyelinated; Rats; Rats, Sp

2012
Dopamine1 receptor agonists reverse opioid respiratory network depression, increase CO2 reactivity.
    Respiratory physiology & neurobiology, 2004, Feb-25, Volume: 139, Issue:3

    Topics: Action Potentials; Analgesics, Opioid; Analysis of Variance; Animals; Apnea; Carbon Dioxide; Cats; D

2004
Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS).
    CJEM, 2006, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Apnea; Blood Gas Monitoring, Transcutaneous; Bradycardia; Cana

2006
[Anesthetic management of cesarean section in a patient with dilated cardiomyopathy].
    Masui. The Japanese journal of anesthesiology, 1995, Mar-03, Volume: 44, Issue:3

    Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Apnea; Cardiomyopathy, Dilated; Cesarean Sectio

1995
Interaction of fentanyl and nitrous oxide on peripheral and cerebral hemodynamics in newborn lambs.
    Anesthesiology, 1994, Volume: 80, Issue:2

    Topics: Anesthesia, General; Animals; Animals, Newborn; Apnea; Cerebrovascular Circulation; Drug Interaction

1994
Fentanyl disposition in cerebrospinal fluid and plasma and its relationship to ventilatory depression in the dog.
    Anesthesiology, 1979, Volume: 50, Issue:4

    Topics: Animals; Apnea; Carbon Dioxide; Dogs; Dose-Response Relationship, Drug; Fentanyl; Lung; Tidal Volume

1979
Post-operative muscle rigidity in an infant.
    European journal of anaesthesiology, 1992, Volume: 9, Issue:5

    Topics: Anesthesia, Intravenous; Apnea; Drug Interactions; Fentanyl; Humans; Hydrocephalus; Infant; Male; Mu

1992
Therapeutic orphans.
    Pediatrics, 1992, Volume: 89, Issue:4 Pt 1

    Topics: Anesthesia, Intravenous; Apnea; Bone Marrow Examination; Child; Fentanyl; Humans; Midazolam

1992
Epidural LA/opioid.
    Anaesthesia and intensive care, 1991, Volume: 19, Issue:4

    Topics: Analgesia, Epidural; Apnea; Bupivacaine; Fentanyl; Humans; Lumbar Vertebrae; Respiratory Insufficien

1991
Complications of epidural analgesia.
    Anaesthesia and intensive care, 1991, Volume: 19, Issue:4

    Topics: Adult; Analgesia, Epidural; Apnea; Bupivacaine; Child; Fentanyl; Humans; Infant; Respiratory Insuffi

1991
Epidural bupivacaine-fentanyl infusions.
    Anaesthesia and intensive care, 1991, Volume: 19, Issue:4

    Topics: Analgesia, Epidural; Apnea; Bupivacaine; Fentanyl; Humans; Respiratory Insufficiency

1991
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Multiple opioid receptors mediate the respiratory depressant effects of fentanyl-like drugs in the rat.
    General pharmacology, 1990, Volume: 21, Issue:5

    Topics: Alfentanil; Anesthesia; Animals; Apnea; Blood Gas Analysis; Fentanyl; Hemodynamics; In Vitro Techniq

1990
Anesthetic complications in an infant with hyperexplexia.
    Anesthesiology, 1990, Volume: 73, Issue:1

    Topics: Anesthesia; Apnea; Fentanyl; Hernia, Inguinal; Humans; Infant; Intraoperative Complications; Male; M

1990
[Apnea following epidural administration of sufentanil].
    Nederlands tijdschrift voor geneeskunde, 1989, May-13, Volume: 133, Issue:19

    Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics; Apnea; Female; Fentanyl; Humans; Mi

1989
Acute respiratory arrest and rigidity after anesthesia with sufentanil: a case report.
    Anesthesiology, 1985, Volume: 63, Issue:6

    Topics: Acute Disease; Adult; Anesthesia, General; Anesthetics; Apnea; Coma; Fentanyl; Humans; Male; Muscle

1985
Prevention of complications associated with intravenous sedation and general anesthesia.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1986, Volume: 44, Issue:4

    Topics: Adult; Anesthesia, Dental; Anesthesia, General; Anesthesia, Intravenous; Anesthetics; Apnea; Arrhyth

1986
[Propofol in scheduled orthopedic surgery].
    Cahiers d'anesthesiologie, 1987, Volume: 35, Issue:6

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics; Apnea; Drug Evaluation; Fem

1987
Use of i.v. fentanyl in the outpatient treatment of pediatric facial trauma.
    The Journal of trauma, 1985, Volume: 25, Issue:11

    Topics: Ambulatory Surgical Procedures; Apnea; Child; Child, Preschool; Emergencies; Facial Injuries; Fentan

1985
[Advantages of neuroleptic analgesia in arteriographic studies (experiences with Thalamonal)].
    Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1971, Volume: 114, Issue:5

    Topics: Adolescent; Adult; Aged; Angiography; Apnea; Benperidol; Blood Pressure; Drug Eruptions; Drug Hypers

1971
Sedation for cataract surgery. Comparison of Carbrital and neuroleptanalgesia.
    The British journal of ophthalmology, 1970, Volume: 54, Issue:10

    Topics: Aged; Apnea; Arrhythmias, Cardiac; Benperidol; Butyrates; Cataract Extraction; Fentanyl; Humans; Hyp

1970
Anaesthesia for microsurgery of the larynx. General anaesthesia combined with neuroleptanalgesia.
    Anaesthesia, 1971, Volume: 26, Issue:2

    Topics: Anesthesia, General; Apnea; Benperidol; Blood Pressure; Child; Fentanyl; Halothane; Humans; Larynx;

1971
[On the significance of oxygen supply in drug induced central respiratory depression].
    Wiener klinische Wochenschrift, 1967, Jun-16, Volume: 79, Issue:24

    Topics: Animals; Apnea; Carbon Dioxide; Fentanyl; Hypercapnia; Hypoxia; Neuroleptanalgesia; Oxygen Consumpti

1967