fentanyl and Anxiety studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

Excerpt	Relevance	Reference
"This study investigates the effects of COMTval158met gene polymorphism on maternal anxiety and pain during delivery and on the analgesic and anxiety efficacy of dexmedetomidine during delivery."	9.51	Comparative study of the efficacy of dexmedetomidine and fentanyl on anxiety and pain of parturients with different COMTva1158met genotypes. ( Feng, YJ; Han, J; Pu, CX; Tang, LJ; Zhang, Y, 2022)
"We sought to evaluate the efficacy of using a quick response (QR) code within video education to guide proper use of fentanyl transdermal patches and control pain, depression, and anxiety levels in cancer patients."	9.34	Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial. ( Chen, J; Hu, X; Mao, X; Rao, Y; Xuan, Z; Yang, S; Ye, Z; Zhang, Y, 2020)
"Preoperative pregabalin administration (75-300 mg po) increased perioperative sedation in a dose-related fashion, but failed to reduce preoperative state anxiety, postoperative pain, or to improve the recovery process after minor elective surgery procedures."	9.14	The effect of pregabalin on preoperative anxiety and sedation levels: a dose-ranging study. ( Klein, K; Taylor, J; Tufanogullari, B; White, PF, 2009)
" The purpose of this study was to determine whether families of children with acute leukemia prefer propofol alone or propofol plus fentanyl for lumbar puncture (LP) sedation."	9.13	Sedative preference of families for lumbar punctures in children with acute leukemia: propofol alone or propofol and fentanyl. ( Cechvala, MM; Christenson, D; Eickhoff, JC; Hollman, GA, 2008)
"Our aim was to find out whether intravenous fentanyl was effective in reducing the pain of first-trimester abortion."	9.09	A randomized controlled trial of fentanyl for abortion pain. ( Rawling, MJ; Wiebe, ER, 2001)
"Ketamine, 5 mg iv, is as effective as 50 microg fentanyl, iv, in alleviating patient anxiety and in providing adequate sedation during the procedures necessary for epidural catheter placement, without inducing severe complications."	9.09	Patient anxiety scores after low-dose ketamine or fentanyl for epidural catheter placement. ( Dohi, S; Iida, H; Oda, A, 2000)
"This exploratory study shows that IV Fentanyl can alleviate dyspnea in some patients but is an example of the difficulties conducting dyspnea research."	7.83	Intravenous Fentanyl for Dyspnea at the End of Life: Lessons for Future Research in Dyspnea. ( Pang, GS; Qu, LM; Tan, YY; Yee, AC, 2016)
"Midazolam was found to be the drug of preference for the majority of patients."	6.67	Midazolam versus fentanyl as premedication for painful procedures in children with cancer. ( Conner, K; Dickson, N; Luzins, J; McGorray, S; Reilly, K; Sandler, ES; Weyman, C, 1992)
"This study investigates the effects of COMTval158met gene polymorphism on maternal anxiety and pain during delivery and on the analgesic and anxiety efficacy of dexmedetomidine during delivery."	5.51	Comparative study of the efficacy of dexmedetomidine and fentanyl on anxiety and pain of parturients with different COMTva1158met genotypes. ( Feng, YJ; Han, J; Pu, CX; Tang, LJ; Zhang, Y, 2022)
"Fentanyl-induced ALB was also prevented by a single 50% N(2)O exposure."	5.38	A high-dose of fentanyl induced delayed anxiety-like behavior in rats. Prevention by a NMDA receptor antagonist and nitrous oxide (N(2)O). ( Ben Boujema, M; Bessière, B; Laboureyras, E; Laulin, JP; Simonnet, G, 2012)
"We sought to evaluate the efficacy of using a quick response (QR) code within video education to guide proper use of fentanyl transdermal patches and control pain, depression, and anxiety levels in cancer patients."	5.34	Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial. ( Chen, J; Hu, X; Mao, X; Rao, Y; Xuan, Z; Yang, S; Ye, Z; Zhang, Y, 2020)
"Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES."	5.34	Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007)
"Effective labour analgesia lasting up to 120 minutes was observed in the fentanyl-bupivacaine group but with high incidence of breakthrough pain."	5.17	A COMPARATIVE STUDY ON THE EFFICACY OF TWO REGIMENS OF SINGLE- SHOT SPINAL BLOCK FOR PAIN RELIEF IN WOMEN PRESENTING IN ESTABLISHED LABOUR. ( Chokwe, TM; Ogutu, O; Olang, PO; Tshibuyl, PN, 2013)
"Preoperative pregabalin administration (75-300 mg po) increased perioperative sedation in a dose-related fashion, but failed to reduce preoperative state anxiety, postoperative pain, or to improve the recovery process after minor elective surgery procedures."	5.14	The effect of pregabalin on preoperative anxiety and sedation levels: a dose-ranging study. ( Klein, K; Taylor, J; Tufanogullari, B; White, PF, 2009)
" The purpose of this study was to determine whether families of children with acute leukemia prefer propofol alone or propofol plus fentanyl for lumbar puncture (LP) sedation."	5.13	Sedative preference of families for lumbar punctures in children with acute leukemia: propofol alone or propofol and fentanyl. ( Cechvala, MM; Christenson, D; Eickhoff, JC; Hollman, GA, 2008)
" Although the visual analog scale, Observer's Assessment of Alertness/Sedation Scale, and State and Trait Anxiety Inventory-State Anxiety test did not show statistically significant differences, the State and Trait Anxiety Inventory-Trait Anxiety score was found to be lower in the music group (group 2) than in the midazolam group (group 1)."	5.10	Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy. ( Basar, H; Basar, M; Batislam, E; Ferhat, M; Ozcan, S; Yilmaz, E, 2003)
"Demographic data, hemodynamic variables, sedation and anxiety scores, amnesia, patient and cardiologist satisfaction, and adverse effects were evaluated and compared among coronary angiography patients taking midazolam, midazolam and fentanyl, or placebo before the procedure."	5.09	Comparison of midazolam with or without fentanyl for conscious sedation and hemodynamics in coronary angiography. ( Aykent, R; Baris, S; Karakaya, D; Kirdar, K; Sagkan, O; Tür, A, 2001)
"Our aim was to find out whether intravenous fentanyl was effective in reducing the pain of first-trimester abortion."	5.09	A randomized controlled trial of fentanyl for abortion pain. ( Rawling, MJ; Wiebe, ER, 2001)
"This study was designed to assess the efficacy of oral transmucosal fentanyl citrate (OTFC) for premedication in an adult population and to determine its effects on anxiety, sedation, gastric volume, and gastric fluid acidity."	5.08	Oral transmucosal fentanyl citrate for premedication in adults. ( Connelly, AM; Hayes, WB; Hein, HA; Holub, MC; Macaluso, AD; Ramsay, MA; Suit, CT; Swygert, TH, 1996)
" A high incidence of pain with drug injection was noted among patients receiving propofol (80%)."	5.08	Propofol patient-controlled sedation during hip or knee arthroplasty in elderly patients. ( Ganapathy, S; Gelb, AW; Herrick, IA; Kirkby, J, 1997)
"All children were given oral transmucosal fentanyl, 15 to 20 microgram/kg, prior to the procedure; at its conclusion they were asked to rate the associated pain."	5.08	Consequences of inadequate analgesia during painful procedures in children. ( Bernstein, B; Schechter, NL; Weisman, SJ, 1998)
"To investigate the effects of preanesthetic oral clonidine on total propofol requirement for uniform minor surgery (breast conservative surgery: breast cancer removal with axillary lymph node dissection), and to compare the action of clonidine with that of preanesthetic oral diazepam, a commonly used benzodiazepine."	5.08	The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia. ( Imai, Y; Kagawa, K; Kirita, T; Kishi, Y; Kita, T; Mammoto, T; Murakami, K; Sakai, T; Sugimura, M, 1998)
"Given as a peroral premedicant for geriatric patients having cataract surgery under regional block, a butyrophenone neuroleptic melperon (15-30 mg, n = 50) ranked equally with diazepam (4-10 mg, n = 50), assessed using a qualitative subjective estimation of the patients' anxiety."	5.07	Melperon premedication for cataract surgery. A comparison with diazepam. ( Oikkonen, M, 1994)
" The results of the studies reviewed suggest that intravenous diazepam accomplishes the therapeutic objectives of anxiety relief, decreased pain perception, and amnesia."	5.05	Differential pharmacology of drugs used for intravenous pre-medication. ( Dionne, RA, 1984)
"Patients with IBS who underwent elective colonoscopy procedures expressed higher pre-procedural anxiety scores, required more propofol consumption, and experienced more disruptive movements compared with controls."	3.88	Ambulatory colonoscopy under sedoanalgesia in adult patients with and without irritable bowel syndrome: A prospective, cross-sectional, and double-blind comparison. ( Araz, C; Çelebi, A; Tuncalı, B, 2018)
"This exploratory study shows that IV Fentanyl can alleviate dyspnea in some patients but is an example of the difficulties conducting dyspnea research."	3.83	Intravenous Fentanyl for Dyspnea at the End of Life: Lessons for Future Research in Dyspnea. ( Pang, GS; Qu, LM; Tan, YY; Yee, AC, 2016)
" Hypotension was treated by standardized protocol (fluid bolus and ephedrine or phenylephrine depending on maternal heart rate)."	3.78	Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. ( Abu-Lil, M; Eidelman, LA; Elliston, J; Fadon, C; Ginosar, Y; Goshen-Gottstein, Y; Orbach-Zinger, S; Raz, A, 2012)
" Anxiety level and intraoperative fentanyl use were also analyzed."	3.73	[An association between tobacco smoking and basic haemodynamic parameters during induction of anaesthesia in gynecologic patients--a pilot study]. ( Adamski, D; Billert, H; Gaca, M, 2006)
"Induction agent doses, peroperative complications, complaints about pain and emesis during the postoperative period, and time to discharge were studied."	2.68	Anaesthesia for short outpatient procedures. A comparison between thiopentone and propofol in combination with fentanyl or alfentanil. ( Jakobsson, J; Rane, K, 1995)
"The study compared the safety and efficacy of 400-vs 800-micrograms dosage forms for their sedative and anxiolytic effects in adults undergoing a variety of dermatologic outpatient surgical procedures."	2.67	Oral transmucosal fentanyl citrate premedication in patients undergoing outpatient dermatologic procedures. ( Bezzant, JL; Gerwels, JW; Le Maire, L; Pauley, LF; Streisand, JB, 1994)
"Fentanyl was required more often in MF group: median 3."	2.67	Intramuscular dexmedetomidine premedication--an alternative to midazolam-fentanyl-combination in elective hysterectomy? ( Jaakola, ML; Kallio, A; Kanto, J; Scheinin, H, 1994)
"Midazolam was found to be the drug of preference for the majority of patients."	2.67	Midazolam versus fentanyl as premedication for painful procedures in children with cancer. ( Conner, K; Dickson, N; Luzins, J; McGorray, S; Reilly, K; Sandler, ES; Weyman, C, 1992)
" The low- and high-dose nalbuphine groups clinically resembled the fentanyl group in terms of dosing frequency and patients' self-ratings of postoperative analgesia."	2.66	A comparison of clinical and psychological effects of fentanyl and nalbuphine in ambulatory gynecologic patients. ( Earls, F; Garfield, FB; Garfield, JM; Philip, BK; Roaf, E, 1987)
"The combination of fentanyl and droperidol, Innovar, was compared to flunitrazepam (1-2 mg) in a higher dosage (2."	2.65	[High-dose thalamonal-rohypnol for premedication. A randomized double-blind study]. ( Schmidt, R; Tolksdorf, W; Wagener, M, 1984)
"To advance the behavioral genetics of prescription opioid abuse, our prior work identified the 129S1/SvlmJ (S1) and related 129P3/J (P3) mouse substrains, respectively, as low and high opioid-taking."	1.56	Who is HOT and who is LOT? Detailed characterization of prescription opioid-induced changes in behavior between 129P3/J and 129S1/SvlmJ mouse substrains. ( Brewin, LW; Coelho, MA; Ferdousian, S; Gabriella, I; Lieberman, D; Stailey, N; Swauncy, I; Szumlinski, KK; Tran, T, 2020)
" The mean dosage of propofol in group A was significantly higher (62."	1.56	Pre-endoscopic tachycardia predicts increased sedation dose and lower adenoma detection rate in patients undergoing endoscopic procedures: a case control study. ( Ahmad, HS; Baker, FA; Kadah, A; Khoury, T; Mahajnah, M; Mahamid, M; Mari, A; Pellicano, R; Sbeit, W, 2020)
"Our results suggest that the combination of INM and INF may be a safe and effective strategy for procedural sedation in young children undergoing simple laceration repair."	1.51	Safety and effectiveness of intranasal midazolam and fentanyl used in combination in the pediatric emergency department. ( Cosgrove, P; Kienstra, AJ; Ryan, PM; Vezzetti, R; Wilkinson, M, 2019)
" The hot plate test revealed that chronic administration of fentanyl reduced pain sensitivity."	1.51	Effects of chronic fentanyl administration on behavioral characteristics of mice. ( Adachi, M; Fujii, K; Koshidaka, Y; Takao, K, 2019)
" Demographic data, time in ED, and dosage of each medication given were abstracted."	1.35	Inadequate provision of postintubation anxiolysis and analgesia in the ED. ( Bonomo, JB; Butler, AS; Lindsell, CJ; Venkat, A, 2008)
"Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES."	1.34	Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007)

Research

Studies (87)

Authors

Clinical Trials (19)

Trial Overview

Trial Outcomes

Anxiety Reduction

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (24.14)	18.7374
1990's	22 (25.29)	18.2507
2000's	19 (21.84)	29.6817
2010's	17 (19.54)	24.3611
2020's	8 (9.20)	2.80

Authors	Studies
Tang, LJ	1
Han, J	1
Feng, YJ	1
Pu, CX	1
Zhang, Y	2
Arya, S	1
Nagappala, S	1
Krawczyk, N	1
Gi, Y	1
Meacham, MC	1
Bunting, AM	1
Szumlinski, KK	1
Coelho, MA	1
Tran, T	1
Stailey, N	1
Lieberman, D	1
Gabriella, I	1
Swauncy, I	1
Brewin, LW	1
Ferdousian, S	1
Mari, A	1
Khoury, T	1
Mahajnah, M	1
Kadah, A	1
Ahmad, HS	1
Baker, FA	1
Pellicano, R	1
Mahamid, M	1
Sbeit, W	1
Alipio, JB	1
Brockett, AT	1
Fox, ME	1
Tennyson, SS	1
deBettencourt, CA	1
El-Metwally, D	1
Francis, NA	1
Kanold, PO	1
Lobo, MK	1
Roesch, MR	1
Keller, A	1
Rezniczek, GA	1
Hecken, JM	1
Rehman, S	1
Dogan, A	1
Tempfer, CB	1
Hilal, Z	1
Ye, Z	1
Chen, J	1
Hu, X	1
Xuan, Z	1
Yang, S	1
Mao, X	1
Rao, Y	1
Guitart, J	1
Vargas, MI	1
De Sanctis, V	1
Folch, J	1
Salazar, R	1
Fuentes, J	1
Coma, J	1
Ferreras, J	1
Moya, J	1
Tomás, A	1
Estivill, P	1
Rodelas, F	1
Jiménez, AJ	1
Sanz, A	1
Tuncalı, B	1
Araz, C	1
Çelebi, A	1
Ryan, PM	1
Kienstra, AJ	1
Cosgrove, P	1
Vezzetti, R	1
Wilkinson, M	1
Tomaszek, L	1
Cepuch, G	1
Fenikowski, D	1
Fujii, K	1
Koshidaka, Y	1
Adachi, M	1
Takao, K	1
Williams, JM	1
Schuman, S	1
Regen, R	1
Berg, A	1
Stuart, L	1
Raju, J	1
Mabry, W	1
Kink, RJ	1
Nguyen, NQ	1
Toscano, L	1
Lawrence, M	1
Moore, J	1
Holloway, RH	1
Bartholomeusz, D	1
Lidums, I	1
Tam, W	1
Roberts-Thomson, IC	1
Mahesh, VN	1
Debreceni, TL	1
Schoeman, MN	1
Bortone, L	1
Bertolizio, G	1
Engelhardt, T	1
Frawley, G	1
Somaini, M	1
Ingelmo, PM	1
Pang, GS	1
Qu, LM	1
Tan, YY	1
Yee, AC	1
De Franceschi, L	1
Mura, P	1
Schweiger, V	1
Vencato, E	1
Quaglia, FM	1
Delmonte, L	1
Evangelista, M	1
Polati, E	1
Olivieri, O	1
Finco, G	1
Tshibuyl, PN	1
Olang, PO	1
Ogutu, O	1
Chokwe, TM	1
Hoeffe, J	1
Doyon Trottier, E	1
Bailey, B	1
Shellshear, D	1
Lagacé, M	1
Sutter, C	1
Grimard, G	1
Cook, R	1
Babl, FE	1
White, PF	1
Tufanogullari, B	1
Taylor, J	1
Klein, K	1
Lesage, S	1
Drolet, P	1
Donati, F	1
Racine, S	1
Fortier, LP	1
Audy, D	1
Shabanov, PD	1
Lebedev, AA	1
Tramullas, M	1
Dinan, TG	1
Cryan, JF	1
Kulkarni, S	1
Johnson, PC	1
Kettles, S	1
Kasthuri, RS	1
Tuominen, L	1
Salo, J	1
Hirvonen, J	1
Någren, K	1
Laine, P	1
Melartin, T	1
Isometsä, E	1
Viikari, J	1
Raitakari, O	1
Keltikangas-Järvinen, L	1
Hietala, J	1
Bessière, B	2
Laboureyras, E	2
Ben Boujema, M	1
Laulin, JP	2
Simonnet, G	2
Orbach-Zinger, S	1
Ginosar, Y	1
Elliston, J	1
Fadon, C	1
Abu-Lil, M	1
Raz, A	1
Goshen-Gottstein, Y	1
Eidelman, LA	1
Howell, TK	1
Smith, S	1
Rushman, SC	1
Walker, RW	1
Radivan, F	1
Yilmaz, E	1
Ozcan, S	1
Basar, M	1
Basar, H	1
Batislam, E	1
Ferhat, M	1
Hasen, KV	1
Samartzis, D	1
Casas, LA	1
Mustoe, TA	1
Marucci, M	1
Diele, C	1
Bruno, F	1
Fiore, T	1
Martin, ML	1
Lennox, PH	1
Buckley, BT	1
Schupp, CJ	1
Berbaum, K	1
Berbaum, M	1
Lang, EV	2
Billert, H	1
Gaca, M	1
Adamski, D	1
Bytzer, P	1
Lindeberg, B	1
Richebé, P	1
Contarino, A	1
Cechvala, MM	1
Christenson, D	1
Eickhoff, JC	1
Hollman, GA	1
Marc, I	1
Rainville, P	1
Masse, B	1
Verreault, R	1
Vaillancourt, L	1
Vallée, E	1
Dodin, S	1
Bonomo, JB	1
Butler, AS	1
Lindsell, CJ	1
Venkat, A	1
Tolksdorf, W	3
Berlin, J	1
Bethke, U	1
Nieder, G	1
Dionne, RA	1
Wagener, M	1
Schmidt, R	1
Höfling, S	1
Dworzak, H	1
Butollo, W	1
Neef, W	1
Ginsberg, B	1
Gil, KM	1
Muir, M	1
Sullivan, F	1
Williams, DA	1
Glass, PSA	1
Jakobsson, J	1
Rane, K	1
Gerwels, JW	1
Bezzant, JL	1
Le Maire, L	1
Pauley, LF	1
Streisand, JB	2
Oikkonen, M	2
Heine, H	1
Salminen, U	1
Romppanen, O	1
Inberg, P	1
Jaakola, ML	1
Kanto, J	1
Scheinin, H	1
Kallio, A	1
Schutzman, SA	1
Burg, J	1
Liebelt, E	1
Strafford, M	1
Schechter, N	1
Wisk, M	1
Fleisher, G	1
Baraff, LJ	1
Hamilton, D	1
Macaluso, AD	1
Connelly, AM	1
Hayes, WB	1
Holub, MC	1
Ramsay, MA	1
Suit, CT	1
Hein, HA	1
Swygert, TH	1
Epstein, RH	1
Mendel, HG	1
Witkowski, TA	1
Waters, R	1
Guarniari, KM	1
Marr, AT	1
Lessin, JB	1
Manninen, PH	1
Chan, AS	1
Papworth, D	1
Cruise, CJ	1
Chung, F	1
Yogendran, S	1
Little, D	1
Ganapathy, S	1
Herrick, IA	1
Gelb, AW	1
Kirkby, J	1
Davies, SJ	1
Paech, MJ	1
Welch, H	1
Evans, SF	1
Pavy, TJ	1
Weisman, SJ	1
Bernstein, B	1
Schechter, NL	1
Kennedy, RM	1
Porter, FL	1
Miller, JP	1
Jaffe, DM	1
Imai, Y	1
Mammoto, T	1
Murakami, K	1
Kita, T	1
Sakai, T	1
Kagawa, K	1
Kirita, T	1
Sugimura, M	1
Kishi, Y	1
Oda, A	1
Iida, H	1
Dohi, S	1
Baris, S	1
Karakaya, D	1
Aykent, R	1
Kirdar, K	1
Sagkan, O	1
Tür, A	1
Fendt, M	1
Mucha, RF	1
Rawling, MJ	1
Wiebe, ER	1
Gelfman, SS	1
Gracely, RH	1
Driscoll, EJ	1
Wirdzek, PR	1
Sweet, JB	1
Butler, DP	1
Conner, JT	1
Herr, G	1
Katz, RL	1
Dorey, F	1
Pagano, RR	1
Schehl, D	1
Sandler, ES	1
Weyman, C	1
Conner, K	1
Reilly, K	1
Dickson, N	1
Luzins, J	1
McGorray, S	1
Guise, PA	1
Ashburn, MA	1
Tarver, SD	1
Mears, SL	1
Mulder, SM	1
Floet Wilms, AW	1
Luijendijk, RW	1
Elwyn, RA	1
Pace, NL	1
Stanley, TH	1
Mandle, CL	1
Domar, AD	1
Harrington, DP	1
Leserman, J	1
Bozadjian, EM	1
Friedman, R	1
Benson, H	1
Pandit, SK	1
Kothary, SP	1
Feld, LH	1
Champeau, MW	1
van Steennis, CA	1
Scott, JC	1
Klapproth, CE	1
Bein, T	1
Bauer, C	1
Garfield, JM	1
Garfield, FB	1
Philip, BK	1
Earls, F	1
Roaf, E	1
Daub, D	1
Kirschner-Hermanns, R	1
Goldmann, L	1
Ogg, TW	1
Levey, AB	1
van Wijhe, M	1
de Voogt-Frenkel, E	1
Stijnen, T	1
Seibert, W	1
Podlesch, I	1
Klieser, HP	1
Rabanus, T	1
Boulanger, M	1
Dowdy, EG	1
Moore, WT	1
Luczak, J	1
Brodzińska, K	1
Skubiszyńska, A	1
Szmydt, W	1
Morrison, JD	1
Gemperle, M	1
Bühler, JC	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Large Loop Excision of the Transformation Zone (LLETZ) With Versus Without Intraoperative Application of Lugol's Iodine in Women With Cervical Dysplasia: a Prospective Randomized Trial[NCT05132114]		216 participants (Anticipated)	Interventional	2022-01-17	Recruiting
Large Loop Excision of the Transformatione Zone Under General Versus Local Anesthesia: a Randomized Trial.[NCT03494686]		229 participants (Actual)	Interventional	2018-04-03	Completed
A Randomized Controlled Trial of Intranasal Fentanyl in Combination With Midazolam Versus Midazolam Alone for Analgesia and Anxiolysis During Pediatric Facial Laceration Repair[NCT04745260]		100 participants (Anticipated)	Interventional	2021-03-01	Not yet recruiting
Influence of Preoperative Support on Anxiety, Pain and Satisfaction With Postoperative Analgesia in Children and Adolescents After Thoracic Surgeries: a Randomized Double Blind Study[NCT03488459]		112 participants (Actual)	Interventional	2012-03-01	Completed
Preoperative Use of Pregabalin and Analgesia Levels After Laparoscopic Cholecystectomy[NCT01321801]		50 participants (Actual)	Interventional	2009-11-30	Completed
Low Dose Fentanyl/Midazolam Improves Sevoflurane Induction in Adults[NCT00723164]		80 participants (Actual)	Interventional	2005-10-31	Completed
Music Therapy in Procedural Sedation in the Emergency Department[NCT02676206]		60 participants (Actual)	Interventional	2016-02-29	Completed
Effects of Sedation on Spinal Anesthesia-induced Maternal Hypotension in Preoperatively Anxious Parturients Undergoing Urgent Category-1 Cesarean Section: A Historical Cohort Study[NCT02732197]		102 participants (Actual)	Observational	2014-08-31	Completed
Association Between Preoperative Shock Index and Hypotension After Spinal Anaesthesia for Non-elective Caesarean Section: A Prospective Observational Study[NCT04692870]		337 participants (Actual)	Observational	2021-01-06	Completed
The Effect of Preoperative Anxiety on Phenylephrine Dosage During Cesarean Delivery Under Spinal Anesthesia, A Prospective Observational Study.[NCT03696732]		100 participants (Anticipated)	Observational	2018-10-20	Recruiting
A Randomized Prospective Placebo-Controlled Study of the Effects of Lavender Aromatherapy on Preoperative Anxiety in Breast Surgery Patients[NCT01837966]		93 participants (Actual)	Interventional	2013-01-31	Completed
Comparison of Two Different Distraction Methods Affecting the Level of Pain and Anxiety During Extracorporeal Shock Wave Lithotripsy[NCT02725281]		120 participants (Actual)	Interventional	2014-04-30	Completed
A Randomized Controlled Trial to Evaluate the Effects of Music Therapy on Breastfeeding Rates Among Mothers of Premature Newborns[NCT00930761]		101 participants (Actual)	Interventional	2004-03-31	Completed
Randomized Controlled Trial of the Use of Intramuscular Fentanyl for the Incision and Drainage of Abscess in the Emergency Department[NCT01881997]	Phase 4	0 participants (Actual)	Interventional	2011-06-30	Withdrawn (stopped due to IRB modifications made study impractical.)
Tetracaine (Ametop®) Compared to Placebo for Reducing Pain Associated With Intramuscular Injection of Palivizumab (Synagis®) - A Pilot Study[NCT00484393]	Phase 4	7 participants (Actual)	Interventional	2007-11-30	Completed
Distraction in the Emergency Using Virtual Reality for Intravenous Needs in Children to Improve Comfort (DEVINCI): A Pilot Randomized Controlled Trial[NCT03750578]		62 participants (Actual)	Interventional	2018-12-17	Completed
Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions[NCT00596050]	Phase 4	50 participants (Actual)	Interventional	2006-08-31	Completed
Systemic Absorption of Lidocaine After Ultrasound Guided Hematoma Block for Reduction of Different Types of Pediatric Distal Radius Fractures[NCT04359017]	Phase 4	0 participants (Actual)	Interventional	2020-11-01	Withdrawn (stopped due to Sponsoring staff have left institution)
Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090]	Phase 3	30 participants (Actual)	Interventional	2014-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

We hoped to show that lavender aroma therapy reduces preoperative anxiety in patients undergoing breast. The Trait subscale (STAI-TRAID) of the Spielberger State-Trait Anxiety Inventory was administered before and after 10 minutes of aromatherapy treatment pre-surgery. The TRAIT subscale contains 20 questions scored on a Likert scale from 1-4; item scores are summed for a total score ranging from 20 to 80, with higher scores indicating higher anxiety. Change in anxiety was calculated as the score pre-aromatherapy minus the score post-aromatherapy. Higher positive change scores indicate greater reductions in anxiety. (NCT01837966)
Timeframe: 20 minutes before surgery (pre aromatherapy) and 10 minutes before surgery (post aromatherapy)

Maternal Breastfeeding 7-15 Days After Discharge

Intervention	units on a scale (Mean)
Lavender Oil	0.89
Placebo	.74

Maternal breastfeeding means: exclusive maternal breastfeeding, predominant maternal breastfeeding (maternal milk associated to other liquid, except formula) and continuous maternal breastfeeding (maternal milk associate to other food, including formula). (NCT00930761)
Timeframe: At the first follow-up visit (7-15 days after discharge)

Maternal Breastfeeding at 30 Days After Discharge

Intervention	participants (Number)
Control	32
Music Therapy	42

Maternal breastfeeding means exclusive maternal breastfeeding, predominant maternal breastfeeding (maternal milk associated to other liquid, except formula) and continuous maternal breastfeeding (maternal milk associate to other food, including formula). (NCT00930761)
Timeframe: At 30 days after the infant hospital discharge

Maternal Breastfeeding at 60 Days After Discharge

Intervention	participants (Number)
Control	30
Music Therapy	38

Maternal Breastfeeding at Infant Discharge

Intervention	participants (Number)
Control	27
Music Therapy	36

To Determine if a Difference in Pain Scale Ratings is Detectable Following Intramuscular Palivizumab Injection That Was Pre-treated With Placebo or Tetracaine.

Intervention	participants (Number)
Control	33
Music Therapy	42

Parent score 1-10 (1 representing no pain and 10 representing extreme pain) FLACC (Face, Legs, Activity, Cry, Consolability) Score 0-10 (at baseline and post injection) (0 representing no pain and 10 representing extreme pain) Change in FLACC score (NCT00484393)
Timeframe: 2 visits, 1 month apart

Intervention	units on a scale (Mean)
	Parent score	FLACC at baseline	FLACC post injection	Change in FLACC
Placebo	7.3	1.6	9.3	7.7
Tetracaine	7.3	1.7	8.4	6.7

Article	Year
Comparative study of the efficacy of dexmedetomidine and fentanyl on anxiety and pain of parturients with different COMTva1158met genotypes. BMC anesthesiology, 2022, 03-28, Volume: 22, Issue:1 Topics: Analgesia, Epidural; Analgesics, Opioid; Anxiety; Dexmedetomidine; Female; Fentanyl; Genotype; Human	2022
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial. American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:6 Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes	2020
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial. American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:6 Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes	2020
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial. American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:6 Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes	2020
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial. American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:6 Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes	2020
Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial. Drug design, development and therapy, 2020, Volume: 14 Topics: Adult; Aged; Aged, 80 and over; Anxiety; Female; Fentanyl; Health Education; Humans; Male; Middle Ag	2020
Influence of preoperative information support on anxiety, pain and satisfaction with postoperative analgesia in children and adolescents after thoracic surgery: A randomized double blind study. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2019, Volume: 163, Issue:2 Topics: Adolescent; Analgesics; Anxiety; Bupivacaine; Child; Double-Blind Method; Female; Fentanyl; Humans;	2019
Patient-controlled analgesia with inhaled methoxyflurane versus conventional endoscopist-provided sedation for colonoscopy: a randomized multicenter trial. Gastrointestinal endoscopy, 2013, Volume: 78, Issue:6 Topics: Administration, Inhalation; Analgesia, Patient-Controlled; Anesthesia Recovery Period; Anesthetics,	2013
The effect of fentanyl and clonidine on early postoperative negative behavior in children: a double-blind placebo controlled trial. Paediatric anaesthesia, 2014, Volume: 24, Issue:6 Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anxiety; Child; Child Behavior; Child, Preschool; Clo	2014
A COMPARATIVE STUDY ON THE EFFICACY OF TWO REGIMENS OF SINGLE- SHOT SPINAL BLOCK FOR PAIN RELIEF IN WOMEN PRESENTING IN ESTABLISHED LABOUR. East African medical journal, 2013, Volume: 90, Issue:1 Topics: Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Combined; Anesthetics,	2013
The effect of pregabalin on preoperative anxiety and sedation levels: a dose-ranging study. Anesthesia and analgesia, 2009, Volume: 108, Issue:4 Topics: Administration, Oral; Adult; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Antiemetics; Anxie	2009
Low-dose fentanyl-midazolam combination improves sevoflurane induction in adults. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2009, Volume: 56, Issue:10 Topics: Adult; Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Anxiety; Double	2009
Music during interventional radiological procedures, effect on sedation, pain and anxiety: a randomised controlled trial. The British journal of radiology, 2012, Volume: 85, Issue:1016 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anxiety; Female; Fentanyl; Humans; Hypnotics	2012
A comparison of oral transmucosal fentanyl and oral midazolam for premedication in children. Anaesthesia, 2002, Volume: 57, Issue:8 Topics: Administration, Oral; Analgesics, Opioid; Anesthesia Recovery Period; Anxiety; Child; Child, Prescho	2002
Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy. Urology, 2003, Volume: 61, Issue:2 Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Anxiety; Blood Pressure; Fem	2003
Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy. Urology, 2003, Volume: 61, Issue:2 Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Anxiety; Blood Pressure; Fem	2003
Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy. Urology, 2003, Volume: 61, Issue:2 Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Anxiety; Blood Pressure; Fem	2003
Music decreases anxiety and provides sedation in extracorporeal shock wave lithotripsy. Urology, 2003, Volume: 61, Issue:2 Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Anti-Anxiety Agents; Anxiety; Blood Pressure; Fem	2003
Subarachnoid anaesthesia in caesarean delivery: effects on alertness. Minerva anestesiologica, 2003, Volume: 69, Issue:11 Topics: Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Anxiety;	2003
Pain and anxiety during interventional radiologic procedures: effect of patients' state anxiety at baseline and modulation by nonpharmacologic analgesia adjuncts. Journal of vascular and interventional radiology : JVIR, 2005, Volume: 16, Issue:12 Topics: Adaptation, Psychological; Aged; Analgesia, Patient-Controlled; Analysis of Variance; Anesthetics, I	2005
Impact of an information video before colonoscopy on patient satisfaction and anxiety - a randomized trial. Endoscopy, 2007, Volume: 39, Issue:8 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anxiety; Audiovisual Aids; Colonoscopy; Con	2007
Sedative preference of families for lumbar punctures in children with acute leukemia: propofol alone or propofol and fentanyl. Journal of pediatric hematology/oncology, 2008, Volume: 30, Issue:2 Topics: Acute Disease; Adolescent; Anxiety; Child; Child, Preschool; Cross-Over Studies; Double-Blind Method	2008
Hypnotic analgesia intervention during first-trimester pregnancy termination: an open randomized trial. American journal of obstetrics and gynecology, 2008, Volume: 199, Issue:5 Topics: Abortion, Induced; Adolescent; Adult; Anxiety; Female; Fentanyl; Humans; Hypnosis, Anesthetic; Hypno	2008
[Psychosomatic effects of intramuscular premedication wtih flunitrazepam, innovar and a placebo in combination with atropine (author's transl)]. Anasthesie, Intensivtherapie, Notfallmedizin, 1981, Volume: 16, Issue:1 Topics: Adult; Amnesia; Anti-Anxiety Agents; Anxiety; Atropine; Droperidol; Drug Combinations; Drug Therapy,	1981
Differential pharmacology of drugs used for intravenous pre-medication. Journal of dental research, 1984, Volume: 63, Issue:6 Topics: Amnesia; Analgesics; Analgesics, Opioid; Anesthesia, Dental; Anesthesia, Intravenous; Anti-Anxiety A	1984
[High-dose thalamonal-rohypnol for premedication. A randomized double-blind study]. Der Anaesthesist, 1984, Volume: 33, Issue:10 Topics: Adolescent; Adult; Aged; Anesthetics; Anxiety; Blood Pressure; Body Weight; Clinical Trials as Topic	1984
[The anxiety process under various high doses of thalamonal for premedication]. Der Anaesthesist, 1983, Volume: 32, Issue:11 Topics: Anxiety; Droperidol; Drug Combinations; Female; Fentanyl; Humans; Male; Preanesthetic Medication; Ti	1983
The influence of lockout intervals and drug selection on patient-controlled analgesia following gynecological surgery. Pain, 1995, Volume: 62, Issue:1 Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anxiety; Female; Fentany	1995
Anaesthesia for short outpatient procedures. A comparison between thiopentone and propofol in combination with fentanyl or alfentanil. Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:4 Topics: Abortion, Induced; Adult; Alfentanil; Ambulatory Surgical Procedures; Anesthesia Recovery Period; An	1995
Oral transmucosal fentanyl citrate premedication in patients undergoing outpatient dermatologic procedures. The Journal of dermatologic surgery and oncology, 1994, Volume: 20, Issue:12 Topics: Administration, Oral; Adult; Aged; Ambulatory Surgical Procedures; Anti-Anxiety Agents; Anxiety; Blo	1994
Melperon premedication for cataract surgery. A comparison with diazepam. Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:3 Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesia; Antipsychotic Agents; Anxiety; Blood Press	1994
Dixyrazine premedication for cataract surgery. A comparison with diazepam. Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:3 Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesia; Antipsychotic Agents; Anxiety; Blood Press	1994
Intramuscular dexmedetomidine premedication--an alternative to midazolam-fentanyl-combination in elective hysterectomy? Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:3 Topics: Adrenergic alpha-Agonists; Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Anxiety; Bloo	1994
Oral transmucosal fentanyl citrate for premedication of children undergoing laceration repair. Annals of emergency medicine, 1994, Volume: 24, Issue:6 Topics: Administration, Oral; Anxiety; Child; Child, Preschool; Conscious Sedation; Emergencies; Fentanyl; H	1994
Oral transmucosal fentanyl citrate for premedication in adults. Anesthesia and analgesia, 1996, Volume: 82, Issue:1 Topics: Administration, Oral; Adult; Analgesics, Opioid; Anxiety; Blood Pressure; Double-Blind Method; Femal	1996
The safety and efficacy of oral transmucosal fentanyl citrate for preoperative sedation in young children. Anesthesia and analgesia, 1996, Volume: 83, Issue:6 Topics: Administration, Oral; Analgesics, Opioid; Anesthesia Recovery Period; Anxiety; Anxiety, Separation;	1996
Conscious sedation for interventional neuroradiology: a comparison of midazolam and propofol infusion. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:1 Topics: Adult; Anesthetics, Intravenous; Anxiety; Attitude of Health Personnel; Cerebrovascular Disorders; C	1997
Music increases satisfaction in elderly outpatients undergoing cataract surgery. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:1 Topics: Aged; Alfentanil; Ambulatory Surgical Procedures; Analysis of Variance; Anesthesia, Intravenous; Ane	1997
Propofol patient-controlled sedation during hip or knee arthroplasty in elderly patients. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:4 Topics: Adjuvants, Anesthesia; Aged; Anesthesia, Conduction; Anxiety; Arthroplasty; Cognition; Conscious Sed	1997
Maternal experience during epidural or combined spinal-epidural anesthesia for cesarean section: a prospective, randomized trial. Anesthesia and analgesia, 1997, Volume: 85, Issue:3 Topics: Adult; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesth	1997
Consequences of inadequate analgesia during painful procedures in children. Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:2 Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa	1998
Consequences of inadequate analgesia during painful procedures in children. Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:2 Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa	1998
Consequences of inadequate analgesia during painful procedures in children. Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:2 Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa	1998
Consequences of inadequate analgesia during painful procedures in children. Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:2 Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa	1998
Consequences of inadequate analgesia during painful procedures in children. Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:2 Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa	1998
Consequences of inadequate analgesia during painful procedures in children. Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:2 Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa	1998
Consequences of inadequate analgesia during painful procedures in children. Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:2 Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa	1998
Consequences of inadequate analgesia during painful procedures in children. Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:2 Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa	1998
Consequences of inadequate analgesia during painful procedures in children. Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:2 Topics: Administration, Oral; Adolescent; Analgesics, Opioid; Analysis of Variance; Anxiety; Bone Marrow Exa	1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics, 1998, Volume: 102, Issue:4 Pt 1 Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil	1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics, 1998, Volume: 102, Issue:4 Pt 1 Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil	1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics, 1998, Volume: 102, Issue:4 Pt 1 Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil	1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics, 1998, Volume: 102, Issue:4 Pt 1 Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil	1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics, 1998, Volume: 102, Issue:4 Pt 1 Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil	1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics, 1998, Volume: 102, Issue:4 Pt 1 Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil	1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics, 1998, Volume: 102, Issue:4 Pt 1 Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil	1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics, 1998, Volume: 102, Issue:4 Pt 1 Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil	1998
Comparison of fentanyl/midazolam with ketamine/midazolam for pediatric orthopedic emergencies. Pediatrics, 1998, Volume: 102, Issue:4 Pt 1 Topics: Adolescent; Analgesics, Opioid; Anesthetics, Dissociative; Anti-Anxiety Agents; Anxiety; Child; Chil	1998
The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia. Journal of clinical anesthesia, 1998, Volume: 10, Issue:8 Topics: Administration, Oral; Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous;	1998
Patient anxiety scores after low-dose ketamine or fentanyl for epidural catheter placement. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2000, Volume: 47, Issue:9 Topics: Adult; Analgesia, Epidural; Anesthetics, Dissociative; Anesthetics, Intravenous; Anxiety; Female; Fe	2000
Comparison of midazolam with or without fentanyl for conscious sedation and hemodynamics in coronary angiography. The Canadian journal of cardiology, 2001, Volume: 17, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anxiety; Conscious Sedation; Coronary Angiograph	2001
A randomized controlled trial of fentanyl for abortion pain. American journal of obstetrics and gynecology, 2001, Volume: 185, Issue:1 Topics: Abortion, Induced; Adult; Analgesics, Opioid; Anxiety; Depression; Female; Fentanyl; Humans; Pain; P	2001
Droperidol, fentanyl and morphine for i.v. surgical premedication. British journal of anaesthesia, 1978, Volume: 50, Issue:5 Topics: Adolescent; Adult; Aged; Anxiety; Clinical Trials as Topic; Double-Blind Method; Droperidol; Female;	1978
Midazolam versus fentanyl as premedication for painful procedures in children with cancer. Pediatrics, 1992, Volume: 89, Issue:4 Pt 1 Topics: Adolescent; Anxiety; Bone Marrow Examination; Child; Child, Preschool; Conscious Sedation; Double-Bl	1992
Oral transmucosal fentanyl citrate for premedication in paediatric outpatients. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:8 Topics: Administration, Oral; Adolescent; Ambulatory Surgical Procedures; Analysis of Variance; Anesthesia,	1990
Relaxation response in femoral angiography. Radiology, 1990, Volume: 174, Issue:3 Pt 1 Topics: Angiography; Anxiety; Diazepam; Femoral Artery; Fentanyl; Humans; Music; Pain; Random Allocation; Re	1990
Intravenous narcotics for premedication in outpatient anaesthesia. Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:5 Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Analgesics; Anesthesia, Inhalation; Anxiety; Doub	1989
Preanesthetic medication in children: a comparison of oral transmucosal fentanyl citrate versus placebo. Anesthesiology, 1989, Volume: 71, Issue:3 Topics: Administration, Oral; Anxiety; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Metho	1989
A comparison of clinical and psychological effects of fentanyl and nalbuphine in ambulatory gynecologic patients. Anesthesia and analgesia, 1987, Volume: 66, Issue:12 Topics: Ambulatory Care; Anxiety; Clinical Trials as Topic; Double-Blind Method; Dreams; Female; Fentanyl; H	1987
[Reduction of preoperative anxiety. A study comparing music, Thalamonal and no premedication]. Der Anaesthesist, 1988, Volume: 37, Issue:9 Topics: Adolescent; Adult; Anxiety; Clinical Trials as Topic; Droperidol; Drug Combinations; Fentanyl; Human	1988
Midazolam versus fentanyl/droperidol and placebo as intramuscular premedicant. Acta anaesthesiologica Scandinavica, 1985, Volume: 29, Issue:4 Topics: Adolescent; Adult; Aged; Anxiety; Benzodiazepines; Clinical Trials as Topic; Double-Blind Method; Dr	1985
Studies of drugs given before anaesthesia. XXII. Phenoperidine and fentanyl, alone and in combination with droperidol. British journal of anaesthesia, 1970, Volume: 42, Issue:12 Topics: Analgesics; Anxiety; Benperidol; Drug Synergism; Female; Fentanyl; Heart Rate; Humans; Isonipecotic	1970

Article	Year
Fentanyl in Pressed Oxycodone Pills: A Qualitative Analysis of Online Community Experiences with an Emerging Drug Trend. Substance use & misuse, 2022, Volume: 57, Issue:13 Topics: Anxiety; Fentanyl; Harm Reduction; Humans; Oxycodone; Social Media	2022
Who is HOT and who is LOT? Detailed characterization of prescription opioid-induced changes in behavior between 129P3/J and 129S1/SvlmJ mouse substrains. Genes, brain, and behavior, 2020, Volume: 19, Issue:5 Topics: Analgesics, Opioid; Animals; Anxiety; Choice Behavior; Conditioning, Operant; Female; Fentanyl; Geno	2020
Pre-endoscopic tachycardia predicts increased sedation dose and lower adenoma detection rate in patients undergoing endoscopic procedures: a case control study. Minerva medica, 2020, Volume: 111, Issue:2 Topics: Adenoma; Adult; Aged; Anxiety; Case-Control Studies; Colonoscopy; Endoscopy, Gastrointestinal; Femal	2020
Enduring consequences of perinatal fentanyl exposure in mice. Addiction biology, 2021, Volume: 26, Issue:2 Topics: Animals; Anxiety; Behavior, Animal; Female; Fentanyl; Litter Size; Maternal Behavior; Mice; Narcotic	2021
Breakthrough Pain Management with Sublingual Fentanyl Tablets in Patients with Cancer: Age Subgroup Analysis of a Multicenter Prospective Study. Drugs in R&D, 2017, Volume: 17, Issue:3 Topics: Administration, Sublingual; Age Factors; Aged; Analgesics, Opioid; Anxiety; Breakthrough Pain; Cance	2017
Ambulatory colonoscopy under sedoanalgesia in adult patients with and without irritable bowel syndrome: A prospective, cross-sectional, and double-blind comparison. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2018, Volume: 29, Issue:3 Topics: Aged; Analgesia; Anxiety; Colonoscopy; Cross-Sectional Studies; Dose-Response Relationship, Drug; Do	2018
Safety and effectiveness of intranasal midazolam and fentanyl used in combination in the pediatric emergency department. The American journal of emergency medicine, 2019, Volume: 37, Issue:2 Topics: Administration, Intranasal; Analgesics, Opioid; Anxiety; Child; Child, Preschool; Drug Therapy, Comb	2019
Effects of chronic fentanyl administration on behavioral characteristics of mice. Neuropsychopharmacology reports, 2019, Volume: 39, Issue:1 Topics: Animals; Anxiety; Fentanyl; Locomotion; Male; Maze Learning; Mice; Mice, Inbred C57BL; Narcotics	2019
Intranasal Fentanyl and Midazolam for Procedural Analgesia and Anxiolysis in Pediatric Urgent Care Centers. Pediatric emergency care, 2020, Volume: 36, Issue:9 Topics: Administration, Intranasal; Adolescent; Ambulatory Care; Analgesia; Analgesics, Opioid; Anxiety; Chi	2020
Intravenous Fentanyl for Dyspnea at the End of Life: Lessons for Future Research in Dyspnea. The American journal of hospice & palliative care, 2016, Volume: 33, Issue:3 Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anxiety; Dyspnea; Female; Fentanyl; Humans; Infusions,	2016
Fentanyl Buccal Tablet: A New Breakthrough Pain Medication in Early Management of Severe Vaso-Occlusive Crisis in Sickle Cell Disease. Pain practice : the official journal of World Institute of Pain, 2016, Volume: 16, Issue:6 Topics: Administration, Buccal; Adolescent; Adult; Analgesics, Opioid; Anemia, Sickle Cell; Anti-Inflammator	2016
Intranasal fentanyl and inhaled nitrous oxide for fracture reduction: The FAN observational study. The American journal of emergency medicine, 2017, Volume: 35, Issue:5 Topics: Adolescent; Analgesia; Anesthetics, Inhalation; Anxiety; Australia; Canada; Child; Child, Preschool;	2017
[Behavioral correlations of gradual forced administration of psychoactive drugs]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:6 Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Dexamethasone; Dose-Response Relationship, Drug; Dr	2011
Chronic psychosocial stress induces visceral hyperalgesia in mice. Stress (Amsterdam, Netherlands), 2012, Volume: 15, Issue:3 Topics: Adrenal Glands; Analgesics, Opioid; Animals; Anxiety; Atropine; Body Weight; Chronic Disease; Colon;	2012
Temperament trait Harm Avoidance associates with μ-opioid receptor availability in frontal cortex: a PET study using [(11)C]carfentanil. NeuroImage, 2012, Jul-02, Volume: 61, Issue:3 Topics: Adult; Aging; Analgesics, Opioid; Anxiety; Brain Mapping; Carbon Radioisotopes; Fear; Female; Fentan	2012
A high-dose of fentanyl induced delayed anxiety-like behavior in rats. Prevention by a NMDA receptor antagonist and nitrous oxide (N(2)O). Pharmacology, biochemistry, and behavior, 2012, Volume: 102, Issue:4 Topics: Animals; Anxiety; Excitatory Amino Acid Antagonists; Fentanyl; Male; Nitrous Oxide; Rats; Rats, Spra	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery. British journal of anaesthesia, 2012, Volume: 109, Issue:6 Topics: Adult; Amylases; Analysis of Variance; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Int	2012
[Pain therapy. Exaggerated anxiety regarding opioid administration]. MMW Fortschritte der Medizin, 2002, Jul-26, Volume: 144, Issue:29-30 Topics: Administration, Cutaneous; Analgesics, Opioid; Anxiety; Chronic Disease; Fentanyl; Humans; Pain	2002
An outcome study comparing intravenous sedation with midazolam/fentanyl (conscious sedation) versus propofol infusion (deep sedation) for aesthetic surgery. Plastic and reconstructive surgery, 2003, Volume: 112, Issue:6 Topics: Adult; Aged; Anesthetics, Intravenous; Anxiety; Conscious Sedation; Female; Fentanyl; Humans; Hypnot	2003
Pain and anxiety: two problems, two solutions. Journal of vascular and interventional radiology : JVIR, 2005, Volume: 16, Issue:12 Topics: Adaptation, Psychological; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Anxiety; Attenti	2005
[An association between tobacco smoking and basic haemodynamic parameters during induction of anaesthesia in gynecologic patients--a pilot study]. Przeglad lekarski, 2006, Volume: 63, Issue:10 Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Obstetrical; Anxiety; Blood Pressure; Blood Pressure Monit	2006
Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. Neuropharmacology, 2007, Volume: 53, Issue:6 Topics: Analgesics, Opioid; Animals; Anxiety; Atmosphere Exposure Chambers; Behavior, Animal; Disease Models	2007
Inadequate provision of postintubation anxiolysis and analgesia in the ED. The American journal of emergency medicine, 2008, Volume: 26, Issue:4 Topics: Adult; Aged; Analgesics, Opioid; Anti-Anxiety Agents; Anxiety; Cohort Studies; Emergency Service, Ho	2008
[The anxiety process during various high doses of thalamonal as premedication]. Der Anaesthesist, 1984, Volume: 33, Issue:6 Topics: Anxiety; Droperidol; Drug Combinations; Fentanyl; Humans; Preanesthetic Medication	1984
Conscious sedation of children. Annals of emergency medicine, 1994, Volume: 24, Issue:6 Topics: Anxiety; Child; Conscious Sedation; Emergencies; Fentanyl; Humans; Midazolam; Pain	1994
Anodyne imagery: an alternative to i.v. sedation in interventional radiology. AJR. American journal of roentgenology, 1994, Volume: 162, Issue:5 Topics: Aged; Analgesia; Anxiety; Conscious Sedation; Female; Fentanyl; Humans; Hypnosis; Imagination; Male;	1994
Anxiogenic-like effects of opiate withdrawal seen in the fear-potentiated startle test, an interdisciplinary probe for drug-related motivational states. Psychopharmacology, 2001, Volume: 155, Issue:3 Topics: Acoustic Stimulation; Analgesics, Opioid; Animals; Anxiety; Behavior, Animal; Body Weight; Fear; Fen	2001
Conscious sedation with intravenous drugs: a study of amnesia. Journal of oral surgery (American Dental Association : 1965), 1978, Volume: 36, Issue:3 Topics: Adult; Amnesia; Anesthesia, Dental; Anesthesia, Intravenous; Anxiety; Diazepam; Drug Combinations; F	1978
Asystole following propofol and fentanyl in an anxious patient. Anaesthesia and intensive care, 1991, Volume: 19, Issue:1 Topics: Adult; Ambulatory Surgical Procedures; Anxiety; Female; Fentanyl; Heart Arrest; Humans; Propofol	1991
[Perioperative anxiety behavior of IVF patients and a suitable simplified analgo-sedation procedure in transvaginal follicle puncture]. Geburtshilfe und Frauenheilkunde, 1989, Volume: 49, Issue:7 Topics: Adult; Analgesia; Anesthesia, Intravenous; Anxiety; Arousal; Female; Fentanyl; Fertilization in Vitr	1989
Hypnosis and daycase anaesthesia. A study to reduce pre-operative anxiety and intra-operative anaesthetic requirements. Anaesthesia, 1988, Volume: 43, Issue:6 Topics: Adult; Alfentanil; Ambulatory Surgical Procedures; Anesthesia, General; Anxiety; Female; Fentanyl; H	1988
[Thalamonal premedication as a solution for extreme anxiety and its postoperative consequences]. Der Anaesthesist, 1987, Volume: 36, Issue:11 Topics: Adult; Anesthetics; Anxiety; Droperidol; Drug Combinations; Fentanyl; Humans; Postoperative Complica	1987
[Measures for the sedation of uncooperative and anxious patients in dental practice]. Deutsche zahnarztliche Zeitschrift, 1974, Volume: 29, Issue:9 Topics: Anesthesia, Dental; Anthracenes; Anxiety; Atropine; Dental Care; Diazepam; Droperidol; Drug Therapy,	1974
[A case of "cerebral curarization"]. Canadian Anaesthetists' Society journal, 1972, Volume: 19, Issue:2 Topics: Aged; Anesthesia, Local; Anxiety; Benperidol; Cardiac Surgical Procedures; Female; Fentanyl; Humans;	1972
Droperidol and fentanyl combination: effect on the human labyrinth. Anesthesiology, 1969, Volume: 30, Issue:6 Topics: Adult; Anxiety; Benperidol; Calorimetry; Drug Synergism; Ear, Inner; Fentanyl; Galvanic Skin Respons	1969
Neuroleptanalgesia II in recent myocardial infarction. Polish medical journal, 1969, Volume: 8, Issue:6 Topics: Adult; Aged; Anxiety; Butyrophenones; Female; Fentanyl; Humans; Injections, Intravenous; Male; Middl	1969
[Does the neuroleptoanalgesia have a place in the intensive care units?]. Schweizerische medizinische Wochenschrift, 1966, Feb-05, Volume: 96, Issue:5 Topics: Anxiety; Benperidol; Cardiovascular Diseases; Fentanyl; Humans; Intensive Care Units; Neuroleptanalg	1966

fentanyl and Anxiety