Page last updated: 2024-10-27

fentanyl and Amnesia

fentanyl has been researched along with Amnesia in 21 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to determine the duration of amnesia associated with the intravenous usage of midazolam and fentanyl."9.06Duration of amnesia associated with midazolam/fentanyl intravenous sedation. ( Bullard, DE; Miller, RI; Patrissi, GA, 1989)
"Dexmedetomidine is characterized with effects of sedation, analgesia, amnesia and lack of respiratory depression."5.14The effectiveness of dexmedetomidine infusion for sedating oral cancer patients undergoing awake fibreoptic nasal intubation. ( Chu, KS; Hsu, HT; Lu, IC; Tsai, CJ; Wang, FY; Wang, HM, 2010)
" Low-dose intravenous ketamine as the primary anesthetic following premedication with fentanyl and midazolam, and in conjunction with nitrous oxide, appeared to produce less hypoxia, hypercarbia, and apnea than when methohexital was used."5.07A double-blind comparison of low-dose intravenous ketamine and methohexital in adults. ( Anderson, JA; Blankstein, KC, 1991)
"The purpose of this study was to determine the duration of amnesia associated with the intravenous usage of midazolam and fentanyl."5.06Duration of amnesia associated with midazolam/fentanyl intravenous sedation. ( Bullard, DE; Miller, RI; Patrissi, GA, 1989)
" The results of the studies reviewed suggest that intravenous diazepam accomplishes the therapeutic objectives of anxiety relief, decreased pain perception, and amnesia."5.05Differential pharmacology of drugs used for intravenous pre-medication. ( Dionne, RA, 1984)
"An opioid-associated amnestic syndrome (OAS) characterized by acute onset memory loss and bilateral hippocampal signal abnormalities on brain imaging in the setting of a history of opioid use, most notably fentanyl, has been reported."3.96Opioid-associated amnestic syndrome: Description of the syndrome and validation of a proposed definition. ( Barash, JA; Boyle, K; DeMaria, A; Ganetsky, M; Lev, MH; Lim, C; Watson, CJ; Whitledge, J, 2020)
"0 mg midazolam alone (n = 160), midazolam combined with either 50-100 mg fentanyl intramuscularly (n = 160), or 0."2.76Sedation, analgesia, and cardiorespiratory function in colonoscopy using midazolam combined with fentanyl or propofol. ( Shen, SR; Tang, WL; Wang, F; Xiao, DH; Xu, CX, 2011)
"Thiopental has mild memory effects whereas fentanyl has none."2.68The comparative amnestic effects of midazolam, propofol, thiopental, and fentanyl at equisedative concentrations. ( Feshchenko, VA; Reinsel, RA; Veselis, RA; Wroński, M, 1997)
" Dosage was: propofol, bolus 1."2.67Total i.v. anaesthesia with propofol-alfentanil or propofol-fentanyl. ( Fruergård, K; Jenstrup, M; Møller, AM; Nielsen, J; Wiberg-Jørgensen, F, 1990)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19907 (33.33)18.7374
1990's3 (14.29)18.2507
2000's0 (0.00)29.6817
2010's9 (42.86)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Barash, JA4
Kofke, WA1
DeMaria, A3
Gallagher, RE1
Taylor, RG2
Mirsattari, SM2
Lee, DH2
Whitledge, J1
Watson, CJ1
Boyle, K1
Lim, C1
Lev, MH2
Ganetsky, M2
Duru, UB1
Pawar, G1
Miller, LE1
Thiruselvam, IK1
Haut, MW1
Boyle, KL1
Raman, V1
Toce, MS1
Kaplan, S1
Worth, JL1
Budhram, A1
Melcer, T1
Walker, J1
Sechriest, VF1
Lebedda, M1
Quinn, K1
Galarneau, M1
Chu, KS1
Wang, FY1
Hsu, HT1
Lu, IC1
Wang, HM1
Tsai, CJ1
Wang, F1
Shen, SR1
Xiao, DH1
Xu, CX1
Tang, WL1
Rinehart, JB1
Baker, B1
Raphael, D1
Tolksdorf, W1
Berlin, J1
Bethke, U1
Nieder, G1
Dionne, RA1
Shane, SM1
Sebel, PS1
Bovill, JG1
Wauquier, A1
Rog, P1
Veselis, RA1
Reinsel, RA1
Feshchenko, VA1
Wroński, M1
Gelfman, SS1
Gracely, RH1
Driscoll, EJ1
Wirdzek, PR1
Sweet, JB1
Butler, DP1
Blankstein, KC1
Anderson, JA1
Jenstrup, M1
Nielsen, J1
Fruergård, K1
Møller, AM1
Wiberg-Jørgensen, F1
Miller, RI1
Bullard, DE1
Patrissi, GA1
d' Hollander, AA1
Monteny, E1
Dewachter, B1
Sanders, M1
Dubois-Primo, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT02039453]160 participants (Anticipated)Interventional2013-09-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

8 trials available for fentanyl and Amnesia

ArticleYear
The effectiveness of dexmedetomidine infusion for sedating oral cancer patients undergoing awake fibreoptic nasal intubation.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:1

    Topics: Adult; Aged; Amnesia; Anesthetics, Intravenous; Conscious Sedation; Dexmedetomidine; Female; Fentany

2010
Sedation, analgesia, and cardiorespiratory function in colonoscopy using midazolam combined with fentanyl or propofol.
    International journal of colorectal disease, 2011, Volume: 26, Issue:6

    Topics: Amnesia; Analgesia; Blood Pressure; Colonoscopy; Demography; Drug Therapy, Combination; Female; Fent

2011
[Psychosomatic effects of intramuscular premedication wtih flunitrazepam, innovar and a placebo in combination with atropine (author's transl)].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1981, Volume: 16, Issue:1

    Topics: Adult; Amnesia; Anti-Anxiety Agents; Anxiety; Atropine; Droperidol; Drug Combinations; Drug Therapy,

1981
Differential pharmacology of drugs used for intravenous pre-medication.
    Journal of dental research, 1984, Volume: 63, Issue:6

    Topics: Amnesia; Analgesics; Analgesics, Opioid; Anesthesia, Dental; Anesthesia, Intravenous; Anti-Anxiety A

1984
The comparative amnestic effects of midazolam, propofol, thiopental, and fentanyl at equisedative concentrations.
    Anesthesiology, 1997, Volume: 87, Issue:4

    Topics: Adult; Amnesia; Double-Blind Method; Female; Fentanyl; Humans; Hypnotics and Sedatives; Male; Memory

1997
A double-blind comparison of low-dose intravenous ketamine and methohexital in adults.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1991, Volume: 49, Issue:5

    Topics: Adolescent; Adult; Amnesia; Anesthesia, Dental; Apnea; Carbon Dioxide; Double-Blind Method; Female;

1991
Total i.v. anaesthesia with propofol-alfentanil or propofol-fentanyl.
    British journal of anaesthesia, 1990, Volume: 64, Issue:6

    Topics: Adult; Alfentanil; Amnesia; Anesthesia, Intravenous; Blood Pressure; Cognition; Drug Combinations; F

1990
Duration of amnesia associated with midazolam/fentanyl intravenous sedation.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1989, Volume: 47, Issue:2

    Topics: Adolescent; Adult; Amnesia; Anesthesia, Dental; Anesthesia, Intravenous; Double-Blind Method; Fentan

1989

Other Studies

13 other studies available for fentanyl and Amnesia

ArticleYear
Amnesia as an Adverse Event Associated With Fentanyl: An Analysis of the US Food and Drug Administration Adverse Event Reporting System, 2011-2021.
    Journal of neurosurgical anesthesiology, 2024, Jan-01, Volume: 36, Issue:1

    Topics: Amnesia; Fentanyl; Humans; United States; United States Food and Drug Administration

2024
Fentanyl patch probably not related to amnesia in case.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2019, 11-04, Volume: 191, Issue:44

    Topics: Amnesia; Analgesics, Opioid; Fentanyl; Humans; Transdermal Patch

2019
The authors respond to "Fentanyl patch probably not related to amnesia in case".
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2019, 11-04, Volume: 191, Issue:44

    Topics: Amnesia; Analgesics, Opioid; Fentanyl; Humans; Transdermal Patch

2019
Opioid-associated amnestic syndrome: Description of the syndrome and validation of a proposed definition.
    Journal of the neurological sciences, 2020, Oct-15, Volume: 417

    Topics: Amnesia; Analgesics, Opioid; Fentanyl; Hippocampus; Humans; Syndrome

2020
An Unusual Amnestic Syndrome Associated With Combined Fentanyl and Cocaine Use.
    Annals of internal medicine, 2018, 05-15, Volume: 168, Issue:10

    Topics: Adult; Amnesia; Cocaine-Related Disorders; Fentanyl; Globus Pallidus; Hippocampus; Humans; Male; Opi

2018
Acute Amnestic Syndrome Associated with Fentanyl Overdose.
    The New England journal of medicine, 2018, Mar-22, Volume: 378, Issue:12

    Topics: Acute Disease; Adult; Amnesia; Drug Overdose; Fentanyl; Humans

2018
Opioid-associated amnestic syndrome observed with fentanyl patch use.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2019, 03-25, Volume: 191, Issue:12

    Topics: Administration, Cutaneous; Amnesia; Analgesics, Opioid; Chronic Pain; Female; Fentanyl; Humans; Midd

2019
Glasgow Coma Scores, early opioids, and posttraumatic stress disorder among combat amputees.
    Journal of traumatic stress, 2014, Volume: 27, Issue:2

    Topics: Afghan Campaign 2001-; Amnesia; Amputees; Analgesics, Opioid; Comorbidity; Drug Therapy, Combination

2014
Postoperative global amnesia reversed with flumazenil.
    The neurologist, 2012, Volume: 18, Issue:4

    Topics: Amnesia; Analgesics; Anesthesia, General; Cholangiopancreatography, Endoscopic Retrograde; Desfluran

2012
Conscious sedation and behavioral modification with local standby anesthesia for ophthalmologic surgery.
    Ophthalmic surgery, 1982, Volume: 13, Issue:1

    Topics: Amnesia; Anesthesia, Local; Behavior Therapy; Diazepam; Drug Therapy, Combination; Fentanyl; Humans;

1982
Effects of high-dose fentanyl anesthesia on the electroencephalogram.
    Anesthesiology, 1981, Volume: 55, Issue:3

    Topics: Amnesia; Analgesia; Anesthesia, General; Cardiac Surgical Procedures; Electroencephalography; Fentan

1981
Conscious sedation with intravenous drugs: a study of amnesia.
    Journal of oral surgery (American Dental Association : 1965), 1978, Volume: 36, Issue:3

    Topics: Adult; Amnesia; Anesthesia, Dental; Anesthesia, Intravenous; Anxiety; Diazepam; Drug Combinations; F

1978
Intubation under topical supra-glottic analgesia in unpremedicated and non-fasting patients: amnesic effects of sub-hypnotic doses of diazepam and Innovar.
    Canadian Anaesthetists' Society journal, 1974, Volume: 21, Issue:5

    Topics: Adolescent; Adult; Aged; Amnesia; Analgesia; Cough; Diazepam; Droperidol; Drug Combinations; Female;

1974