Page last updated: 2024-10-27

fentanyl and Abscess

fentanyl has been researched along with Abscess in 3 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Abscess: Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.

Research Excerpts

ExcerptRelevanceReference
"We tested the following hypothesis: The addition of intranasal fentanyl to the standard practice of local infiltration with lidocaine would provide better pain control than lidocaine alone for adult ED patients undergoing I&D."9.51A Randomized, Placebo-Controlled Study of Intranasal Fentanyl as an Analgesic Adjunct For Incision and Drainage of Abscess. ( Baer, J; Feliciano, C; Friedman, BW; Gupta, C; Latev, A; Sharpe, S, 2022)
"In a small sample of children aged 4 to 18 years undergoing abscess I&D, IN fentanyl was noninferior, and potentially superior, to IV morphine for reducing procedural pain and distress."9.27Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage. ( Aponte-Patel, L; Babineau, J; Dayan, PS; Fenster, DB; Tsze, DS, 2018)
"We tested the following hypothesis: The addition of intranasal fentanyl to the standard practice of local infiltration with lidocaine would provide better pain control than lidocaine alone for adult ED patients undergoing I&D."5.51A Randomized, Placebo-Controlled Study of Intranasal Fentanyl as an Analgesic Adjunct For Incision and Drainage of Abscess. ( Baer, J; Feliciano, C; Friedman, BW; Gupta, C; Latev, A; Sharpe, S, 2022)
"In a small sample of children aged 4 to 18 years undergoing abscess I&D, IN fentanyl was noninferior, and potentially superior, to IV morphine for reducing procedural pain and distress."5.27Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage. ( Aponte-Patel, L; Babineau, J; Dayan, PS; Fenster, DB; Tsze, DS, 2018)
" We experienced a case of pentazocine inhibiting itch evoked by intrathecal fentanyl in a patient with idiopathic pulmonary fibrosis (IPF)."3.80[Treatment of intrathecal fentanyl-induced itch with pentazocine: a case report]. ( Hirabayashi, M; Imamachi, N; Saito, Y; Sakakihara, M, 2014)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Latev, A1
Baer, J1
Sharpe, S1
Gupta, C1
Feliciano, C1
Friedman, BW1
Hirabayashi, M1
Imamachi, N1
Sakakihara, M1
Saito, Y1
Fenster, DB1
Dayan, PS1
Babineau, J1
Aponte-Patel, L1
Tsze, DS1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Two Methods Using Intranasal Lidocaine to Alleviate Discomfort Associated With Administration of Intranasal Midazolam in Children.[NCT03054844]Phase 255 participants (Actual)Interventional2017-04-03Completed
Efficacy of Intranasal Fentanyl at Reducing Pain During Abscess Incision and Drainage (I&D) in Children[NCT01549002]Phase 320 participants (Actual)Interventional2012-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Parental Satisfaction

If my child needed medications to stay calm for a procedure, I would like to use these same medications again. (NCT03054844)
Timeframe: 1 minute

InterventionParticipants (Count of Participants)
PREMED10
PREMIX12

Procedural Distress, Cry Duration

Cry duration was measured in seconds and defined as the time from onset of crying following administration of an IN medication until the cessation of crying sounds and/or tears. If a patient did not cry, the cry duration was zero (NCT03054844)
Timeframe: 10 minutes

Interventionseconds (Mean)
PREMED84
PREMIX73

Procedural Distress, FLACC

The Faces, Legs, Activity, Cry, Consolability (FLACC) scale is comprised of five criteria (face, legs, activity, cry, consolability), with a possible score of 0 to 2 units on a scale for each criteria and a possible total score of 0 to 10 units on a scale (0 meaning no pain, 10 meaning most pain). (NCT03054844)
Timeframe: 10 minutes

InterventionUnits on a scale (Mean)
PREMED6.7
PREMIX7

Procedural Distress, OSBD-R

The Observational Scale of Behavioral Distress-Revised (OSBD-R) is an observational measure of pain and distress shown to have strong validity in children. The scale is an 8-factor, weighted observational scale used to measure distress associated with medical procedures, which has been validated in children and adults aged 1 to 20 years. The total Observational Scale of Behavioral Distress-Revised score is the sum of the scale scores for each phase, with each phase assigned a score from 0 to 23.5 units on a scale (0=no distress, 23.5=maximum distress), based on the frequency and types of behaviors observed during a predetermined number of 15-second intervals during each phase. There were four phases so the range of scores for the total OSBD-R was 0 to 94 units on a scale, with a higher score indicated a greater degree of distress. (NCT03054844)
Timeframe: 10 minutes

InterventionUnits on a scale (Mean)
PREMED6.4
PREMIX7

Procedural Pain

The Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) utilizes six observational factors (cry, facial, verbal, torso, touch, and legs) to evaluate pain in young children and can be used to monitor the effectiveness of interventions for reducing the pain and discomfort of an intervention. This scale rates each behavior numerically, with a score of 4-6 units on a scale representing no pain, and a maximum score of 13 units on a scale representing (most pain perceived). (NCT03054844)
Timeframe: 10 minutes

InterventionUnits on a scale (Mean)
PREMED10.6
PREMIX10.5

Provider Satisfaction

I would like to use this method of administering intranasal midazolam and lidocaine again in the future (NCT03054844)
Timeframe: 1 minute

InterventionParticipants (Count of Participants)
PREMED8
PREMIX24

Number of Patients Satisfied With Analgesia Administered

"Number of patients satisfied with analgesia administered will be evaluated by determining the number of patients who report a Likert scale response of somewhat satisfied, very satisfied, or extremely satisfied (i.e. any patient who selects any of these three responses will be considered to have been satisfied with analgesia administered). Patients will be asked 10 minutes after procedure completion. If the patient is 8 years of age and older, both the patient and the parent or guardian will complete a satisfaction survey. If the patients is younger than 8 years, their parent or guardian will complete the satisfaction survey." (NCT01549002)
Timeframe: 10 minutes after procedure completion

InterventionParticipants (Count of Participants)
Intranasal Fentanyl10
Intravenous Morphine4

Score on the Observational Scale of Behavioral Distress Revised (OSBD-R)

Our primary outcome is the Observational Scale of Behavioral Distress - Revised (OSBD-R) to assess observed intra-procedural pain. The total OSBD-R score is a summation of the OSBD-R score of each individual phase. The score in each phase can range from 0 to 23.5. There were four phases in our study, so the range of scores for the total OSBD-R was 0 to 94, with a higher score indicating a greater degree of pain and distress. The four phases in the study are (1) before analgesia administration, (2) ten minutes after analgesia administration but before beginning I&D, (3) immediately post I&D procedure (to ascertain the pain perceived during procedure), and (4) ten minutes after procedure completion. The scores documented here are the total OSBD-R scores. (NCT01549002)
Timeframe: Up to 10 minutes after the procedure completion

Interventionunits on a scale (Mean)
Intranasal Fentanyl5.48
Intravenous Morphine18.92

Score on the Faces Pain Scale Revised (FPS-R)

"The Faces Pain Scale - Revised (FPS-R) is a self-report measure of pain has strong validity and reliability in children 4 - 17 years of age undergoing painful procedures, and will be used to assess patients' self reported pain. A score of 0 means no pain, a score of 10 means very much pain. Therefore, a lower score indicates that a patient is experiencing a lower degree of pain intensity.~Patients will complete the FPS-R at four times during their medical encounter: (1) before analgesia administration, (2) ten minutes after analgesia administration but before beginning I&D, (3) immediately post I&D procedure (to ascertain the pain perceived during procedure), and (4) ten minutes after procedure completion." (NCT01549002)
Timeframe: Up to 10 minutes after procedure completion

,
Interventionunits on a scale (Median)
Before analgesia administration10 min after analgesia, before I&DImmediately post-I&D10 min after procedure completion
Intranasal Fentanyl6241
Intravenous Morphine44105

Trials

2 trials available for fentanyl and Abscess

ArticleYear
A Randomized, Placebo-Controlled Study of Intranasal Fentanyl as an Analgesic Adjunct For Incision and Drainage of Abscess.
    The Journal of emergency medicine, 2022, Volume: 62, Issue:3

    Topics: Abscess; Administration, Intranasal; Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Dra

2022
Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage.
    Pediatric emergency care, 2018, Volume: 34, Issue:9

    Topics: Abscess; Administration, Intranasal; Administration, Intravenous; Adolescent; Analgesics, Opioid; Ch

2018
Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage.
    Pediatric emergency care, 2018, Volume: 34, Issue:9

    Topics: Abscess; Administration, Intranasal; Administration, Intravenous; Adolescent; Analgesics, Opioid; Ch

2018
Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage.
    Pediatric emergency care, 2018, Volume: 34, Issue:9

    Topics: Abscess; Administration, Intranasal; Administration, Intravenous; Adolescent; Analgesics, Opioid; Ch

2018
Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage.
    Pediatric emergency care, 2018, Volume: 34, Issue:9

    Topics: Abscess; Administration, Intranasal; Administration, Intravenous; Adolescent; Analgesics, Opioid; Ch

2018

Other Studies

1 other study available for fentanyl and Abscess

ArticleYear
[Treatment of intrathecal fentanyl-induced itch with pentazocine: a case report].
    Masui. The Japanese journal of anesthesiology, 2014, Volume: 63, Issue:6

    Topics: Abscess; Analgesics, Opioid; Anesthesia, General; Antipruritics; Emergency Medical Services; Fallopi

2014