fenbufen has been researched along with Seizures in 10 studies
fenbufen: structure; RN given refers to parent cpd
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " None of the quinolones tested including BMY-40062 modified the seizures induced by bicuculline, a specific GABA A antagonist." | 3.68 | Pharmacological properties of a new fluoroquinolone on the central nervous system in rodents. ( Guiol, C; Ledoussal, C; Surgé, JM, 1993) |
| "The suppression of the convulsions by 7-nitroindazole was not reversed by the pretreatment of L-arginine." | 1.30 | Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice. ( Masukawa, T; Nakanishi, K; Natsuki, R, 1998) |
| "The effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, were studied in mice." | 1.28 | [Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice]. ( Ally, A; Hara, Y; Murayama, S; Suzuki, T, 1992) |
| " Although treatment with each quinolone or fenbufen alone at a dosage level tested in mice showed no changes, coadministration of a large dose of all quinolones and fenbufen caused convulsant death." | 1.28 | Interaction of the new quinolone antibacterial agent levofloxacin with fenbufen in mice. ( Akahane, K; Furuhama, K; Takayama, S; Tawara, K, 1992) |
| "Mice were observed for convulsions for 90 minutes after the administration of temafloxacin HCl (100 mg/kg orally [p." | 1.28 | Assessment of temafloxacin neurotoxicity in rodents. ( Giardina, WJ, 1991) |
| "Comparing with other pyridonecarboxylic acids (PCAs), the neurotoxicity of (+/-)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4- dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate hydrate (T-3262), which is a new PCA, was investigated in mice in a combination with fenbufen (FBF)." | 1.28 | [Adverse drug interactions between pyridonecarboxylic acids and nonsteroidal antiinflammatory drugs: convulsion after oral or intracerebral administration in mice]. ( Hirai, S; Makino, S; Narita, H; Tanaka, K, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 8 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Sarro, G | 1 |
| Renne, S | 1 |
| Nava, F | 1 |
| De Sarro, A | 1 |
| Guiol, C | 1 |
| Ledoussal, C | 1 |
| Surgé, JM | 1 |
| Masukawa, T | 2 |
| Nakanishi, K | 2 |
| Natsuki, R | 1 |
| Hara, Y | 1 |
| Ally, A | 1 |
| Suzuki, T | 1 |
| Murayama, S | 1 |
| Furuhama, K | 1 |
| Akahane, K | 1 |
| Tawara, K | 1 |
| Takayama, S | 1 |
| Motomura, M | 1 |
| Kataoka, Y | 1 |
| Takeo, G | 1 |
| Shibayama, K | 1 |
| Ohishi, K | 1 |
| Nakamura, T | 1 |
| Niwa, M | 1 |
| Tsujihata, M | 1 |
| Nagataki, S | 1 |
| Giardina, WJ | 1 |
| Hirai, S | 1 |
| Tanaka, K | 1 |
| Makino, S | 1 |
| Narita, H | 1 |
| Morita, H | 1 |
| Maemura, K | 1 |
| Sakai, Y | 1 |
| Kaneda, Y | 1 |
10 other studies available for fenbufen and Seizures
| Article | Year |
|---|---|
Fenbufen pretreatment potentiates the anticonvulsant activity of CPPene and NBQX in DBA/2 mice.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antico | 1994 |
Pharmacological properties of a new fluoroquinolone on the central nervous system in rodents.
Topics: Animals; Anti-Infective Agents; Behavior, Animal; Bicuculline; Body Temperature; Central Nervous Sys | 1993 |
Circadian variation in enoxacin-induced convulsions in mice coadministered with fenbufen.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Brain; Circadian Rhythm; Dr | 1997 |
Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Brain; Enoxacin; Enzyme Inh | 1998 |
[Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice].
Topics: Amino Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Diazepam; Dizocilpin | 1992 |
Interaction of the new quinolone antibacterial agent levofloxacin with fenbufen in mice.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Levoflox | 1992 |
Hippocampus and frontal cortex are the potential mediatory sites for convulsions induced by new quinolones and non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Cortex; Drug Combinations; Enoxacin; Hipp | 1991 |
Assessment of temafloxacin neurotoxicity in rodents.
Topics: Animals; Anti-Infective Agents; Central Nervous System; Ciprofloxacin; Enoxacin; Fluoroquinolones; M | 1991 |
[Adverse drug interactions between pyridonecarboxylic acids and nonsteroidal antiinflammatory drugs: convulsion after oral or intracerebral administration in mice].
Topics: 4-Quinolones; Administration, Oral; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-St | 1989 |
[A case of convulsion, loss of consciousness and subsequent acute renal failure caused by enoxacin and fenbufen].
Topics: Acute Kidney Injury; Adult; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Consciou | 1988 |