fasudil and Sepsis
fasudil has been researched along with Sepsis in 2 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil, which is primarily prescribed to treat cerebral vasospasm, may also inhibit systemic inflammation and prevent sepsis‑induced acute lung injury (ALI) in rats, although the mechanisms remain elusive." | 7.88 | Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats. ( Liu, W; Wang, X; Wang, Y; Zhang, L, 2018) |
| "Fasudil, which is primarily prescribed to treat cerebral vasospasm, may also inhibit systemic inflammation and prevent sepsis‑induced acute lung injury (ALI) in rats, although the mechanisms remain elusive." | 3.88 | Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats. ( Liu, W; Wang, X; Wang, Y; Zhang, L, 2018) |
| "It was picked a model of acute renal injury by an intraperitoneal organization of fasudil." | 1.48 | Fabrication of fasudil hydrochloride modified graphene oxide biocomposites and its defensive effect acute renal injury in septicopyemia rats. ( Chang, L; Fu, J, 2018) |
Research
Studies (2)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Fu, J | 1 |
| Chang, L | 1 |
| Wang, Y | 1 |
| Wang, X | 1 |
| Liu, W | 1 |
| Zhang, L | 1 |
Other Studies
2 other studies available for fasudil and Sepsis
| Article | Year |
|---|---|
Fabrication of fasudil hydrochloride modified graphene oxide biocomposites and its defensive effect acute renal injury in septicopyemia rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Animals; Biocompatible Materials | 2018 |
Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Lung Injury; Animals; Apoptosis; Bronchoalveola | 2018 |