Page last updated: 2024-10-28

fasudil and Sepsis

fasudil has been researched along with Sepsis in 2 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"Fasudil, which is primarily prescribed to treat cerebral vasospasm, may also inhibit systemic inflammation and prevent sepsis‑induced acute lung injury (ALI) in rats, although the mechanisms remain elusive."7.88Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats. ( Liu, W; Wang, X; Wang, Y; Zhang, L, 2018)
"Fasudil, which is primarily prescribed to treat cerebral vasospasm, may also inhibit systemic inflammation and prevent sepsis‑induced acute lung injury (ALI) in rats, although the mechanisms remain elusive."3.88Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats. ( Liu, W; Wang, X; Wang, Y; Zhang, L, 2018)
"It was picked a model of acute renal injury by an intraperitoneal organization of fasudil."1.48Fabrication of fasudil hydrochloride modified graphene oxide biocomposites and its defensive effect acute renal injury in septicopyemia rats. ( Chang, L; Fu, J, 2018)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fu, J1
Chang, L1
Wang, Y1
Wang, X1
Liu, W1
Zhang, L1

Other Studies

2 other studies available for fasudil and Sepsis

ArticleYear
Fabrication of fasudil hydrochloride modified graphene oxide biocomposites and its defensive effect acute renal injury in septicopyemia rats.
    Journal of photochemistry and photobiology. B, Biology, 2018, Volume: 186

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Animals; Biocompatible Materials

2018
Role of the Rho/ROCK signaling pathway in the protective effects of fasudil against acute lung injury in septic rats.
    Molecular medicine reports, 2018, Volume: 18, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Lung Injury; Animals; Apoptosis; Bronchoalveola

2018