Page last updated: 2024-10-18

ethanolamine and Neuroblastoma

ethanolamine has been researched along with Neuroblastoma in 16 studies

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"A concentration-related stimulation of anandamide (arachidonylethanolamide) synthesis by delta 9-tetrahydrocannabinol (THC) was observed in N-18TG2 neuroblastoma cells."7.69Stimulation of anandamide biosynthesis in N-18TG2 neuroblastoma cells by delta 9-tetrahydrocannabinol (THC). ( Burstein, SH; Hunter, SA, 1995)
"After mouse neuroblastoma cells were cultured with [15N]glycine in Dulbecco's modified Eagle's medium for total four days, they gave significant amounts of 15N-atom% excess in phosphatidylserine, phosphatidylethanolamine, ethanolamine plasmalogen, phosphatidylcholine, sphingomyelin and ceramide."7.69Evidence for indirect utilization of glycine for production of N-bases of glycerophospholipids and sphingolipids in mouse neuroblastoma cells by using 15N-labeled glycine. ( Hara, A; Kurahashi, H; Taketomi, T; Uemura, K, 1995)
"The sequential methylation of ethanolamine (Etn) or phosphorylethanolamine to the corresponding choline (Cho) derivatives was studied in both undifferentiated and retinoic acid (RA) differentiated human neuroblastoma clones LA-N-1 and LA-N-2."7.69The conversion of ethanolamine and of its metabolites to choline in human neuroblastoma clones: effect of differentiation induced by retinoic acid. ( Andriamampandry, C; Carrara, M; Dreyfus, H; Freysz, L; Haidar, NE; Kanfer, JN; Massarelli, R, 1994)
"Human neuroblastoma cholinergic LA-N-2 cells were used as an experimental model to test the possibility that the methylation of phosphoethanolamine (PEtn) to phosphocholine (PCho) and free choline (Cho) (Andriamampandry et al."7.69Incorporation of [3H]ethanolamine into acetylcholine by a human cholinergic neuroblastoma clone. ( Andriamampandry, C; Carrara, M; Dreyfus, H; Freysz, L; Haidar, NE; Kanfer, JN; Massarelli, R, 1994)
" Here we present data (1) substantiating further the mechanism by which AnNH is produced by phospholipase D (PLD)-catalysed hydrolysis of N-arachidonoylphosphatidylethanolamine in mouse neuroblastoma N18TG2 cells, and (2) suggesting for the first time that AnNH is biosynthesized via the same mechanism in a non-neuronal cell line, mouse J774 macrophages, together with other acylethanolamides and is possibly involved in the control of the immune/inflammatory response."7.69Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells. ( Buono, A; De Petrocellis, L; Di Marzo, V; Sepe, N, 1996)
"Neuroblastoma cells were used to determine the effect of high carbohydrate and polyol levels on myo-inositol metabolism."7.67myo-Inositol metabolism in 41A3 neuroblastoma cells: effects of high glucose and sorbitol levels. ( Dunlap, JA; Ginsberg, BH; Yorek, MA, 1987)
"We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15."7.67Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986)
" In this study, we used a mitochondrial uncoupler, niclosamide ethanolamine (NEN), to activate mitochondrial respiration, which induced neural differentiation in neuroblastoma cells."4.31Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. ( Banuelos, S; Chiu, B; Forgo, B; Greathouse, RL; Gruber, JJ; He, B; Hu, Z; Jiang, H; Li, A; Li, AM; Li, Y; Rankin, EB; Shih, M; Shimada, H; Tiche, SJ; Ye, J; Yip, M; Zhao, M; Zhou, MN, 2023)
" Herein, quantitative assays were used to examine the endogenous amounts of a panel of PFAMs, as well as the amounts produced after incubation of mouse neuroblastoma N(18)TG(2) and sheep choroid plexus (SCP) cells with the corresponding fatty acids or N-tridecanoylethanolamine."3.78Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2 and SCP cells. ( Barazanji, M; Cameroamortegui, F; Chen, Y; Farrell, EK; Jeffries, KA; Merkler, DJ, 2012)
"A concentration-related stimulation of anandamide (arachidonylethanolamide) synthesis by delta 9-tetrahydrocannabinol (THC) was observed in N-18TG2 neuroblastoma cells."3.69Stimulation of anandamide biosynthesis in N-18TG2 neuroblastoma cells by delta 9-tetrahydrocannabinol (THC). ( Burstein, SH; Hunter, SA, 1995)
"After mouse neuroblastoma cells were cultured with [15N]glycine in Dulbecco's modified Eagle's medium for total four days, they gave significant amounts of 15N-atom% excess in phosphatidylserine, phosphatidylethanolamine, ethanolamine plasmalogen, phosphatidylcholine, sphingomyelin and ceramide."3.69Evidence for indirect utilization of glycine for production of N-bases of glycerophospholipids and sphingolipids in mouse neuroblastoma cells by using 15N-labeled glycine. ( Hara, A; Kurahashi, H; Taketomi, T; Uemura, K, 1995)
"The sequential methylation of ethanolamine (Etn) or phosphorylethanolamine to the corresponding choline (Cho) derivatives was studied in both undifferentiated and retinoic acid (RA) differentiated human neuroblastoma clones LA-N-1 and LA-N-2."3.69The conversion of ethanolamine and of its metabolites to choline in human neuroblastoma clones: effect of differentiation induced by retinoic acid. ( Andriamampandry, C; Carrara, M; Dreyfus, H; Freysz, L; Haidar, NE; Kanfer, JN; Massarelli, R, 1994)
"Human neuroblastoma cholinergic LA-N-2 cells were used as an experimental model to test the possibility that the methylation of phosphoethanolamine (PEtn) to phosphocholine (PCho) and free choline (Cho) (Andriamampandry et al."3.69Incorporation of [3H]ethanolamine into acetylcholine by a human cholinergic neuroblastoma clone. ( Andriamampandry, C; Carrara, M; Dreyfus, H; Freysz, L; Haidar, NE; Kanfer, JN; Massarelli, R, 1994)
" Here we present data (1) substantiating further the mechanism by which AnNH is produced by phospholipase D (PLD)-catalysed hydrolysis of N-arachidonoylphosphatidylethanolamine in mouse neuroblastoma N18TG2 cells, and (2) suggesting for the first time that AnNH is biosynthesized via the same mechanism in a non-neuronal cell line, mouse J774 macrophages, together with other acylethanolamides and is possibly involved in the control of the immune/inflammatory response."3.69Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells. ( Buono, A; De Petrocellis, L; Di Marzo, V; Sepe, N, 1996)
" In this study, we describe the effect of ethanol on the incorporation of radioactive serine, choline and ethanolamine into their respective phospholipids in a neuroblastoma x glioma hybrid cell line (NG 108-15)."3.69Ethanol potentiates the uptake of [14C]serine into phosphatidylserine by base-exchange reaction in NG 108-15 cells. ( Alling, C; Gustavsson, L; Rodríguez, FD, 1996)
"Differences between the influences of phorbol esters (such as 4 beta-12-O-tetradecanoylphorbol 13-acetate) and of fatty acids (such as oleic acid) on the synthesis and turnover of phosphatidylcholine (PtdCho) and other phospholipids have been studied in glioma (C6), neuroblastoma (N1E-115), and hybrid (NG108-15) cells in culture using [methyl-3H]choline, [32P]Pi, [1,2-14C]ethanolamine, or 1-14C-labeled fatty acids as lipid precursors."3.67Alterations of phospholipid metabolism by phorbol esters and fatty acids occur by different intracellular mechanisms in cultured glioma, neuroblastoma, and hybrid cells. ( Byers, DM; Cook, HW; Palmer, FB; Spence, MW, 1989)
"Neuroblastoma cells were used to determine the effect of high carbohydrate and polyol levels on myo-inositol metabolism."3.67myo-Inositol metabolism in 41A3 neuroblastoma cells: effects of high glucose and sorbitol levels. ( Dunlap, JA; Ginsberg, BH; Yorek, MA, 1987)
"We have examined the effects of phorbol esters on phosphatidylcholine (PtdCho) metabolism in the neuroblastoma-glioma hybrid cell line NG108-15."3.67Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters. ( Blusztajn, JK; Freese, A; Liscovitch, M; Wurtman, RJ, 1986)
"Anandamide (AEA) is a lipid molecule belonging to the family of endocannabinoids."1.34Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine. ( Juknat, A; Klin, Y; Matas, D; Pietr, M; Vogel, Z, 2007)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19903 (18.75)18.7374
1990's9 (56.25)18.2507
2000's1 (6.25)29.6817
2010's1 (6.25)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Jiang, H1
Greathouse, RL1
Tiche, SJ1
Zhao, M1
He, B1
Li, Y1
Li, AM1
Forgo, B1
Yip, M1
Li, A1
Shih, M1
Banuelos, S1
Zhou, MN1
Gruber, JJ1
Rankin, EB1
Hu, Z1
Shimada, H1
Chiu, B1
Ye, J1
Byrne, FL1
Bell, JL1
Farrell, EK1
Chen, Y1
Barazanji, M1
Jeffries, KA1
Cameroamortegui, F1
Merkler, DJ1
Matas, D1
Juknat, A1
Pietr, M1
Klin, Y1
Vogel, Z1
Burstein, SH1
Hunter, SA1
Kurahashi, H1
Uemura, K1
Hara, A1
Taketomi, T1
Haidar, NE2
Andriamampandry, C2
Carrara, M2
Kanfer, JN3
Freysz, L2
Dreyfus, H2
Massarelli, R3
Sorrentino, G1
Singh, IN1
Bonavita, V1
Murphy, EJ1
Horrocks, LA1
Di Marzo, V1
De Petrocellis, L1
Sepe, N1
Buono, A1
Rodríguez, FD1
Alling, C1
Gustavsson, L1
Sheff, KY1
Yorek, MA2
Long, JP1
Cook, HW1
Byers, DM1
Palmer, FB1
Spence, MW1
Dunlap, JA1
Ginsberg, BH1
Liscovitch, M1
Freese, A1
Blusztajn, JK1
Wurtman, RJ1

Other Studies

16 other studies available for ethanolamine and Neuroblastoma

ArticleYear
Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma.
    Cancer research, 2023, 01-18, Volume: 83, Issue:2

    Topics: Animals; beta Catenin; Cell Differentiation; Cell Line, Tumor; Epigenome; Ethanolamine; Ethanolamine

2023
Neuroblastoma Differentiation: The Untapped Potential of Mitochondrial Uncouplers.
    Cancer research, 2023, 01-18, Volume: 83, Issue:2

    Topics: Antineoplastic Agents; Cell Differentiation; Epigenome; Ethanolamine; Humans; Neuroblastoma; Niclosa

2023
Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2 and SCP cells.
    Journal of lipid research, 2012, Volume: 53, Issue:2

    Topics: Amides; Animals; Cells, Cultured; Choroid Plexus; Ethanolamine; Ethanolamines; Fatty Acids; Fatty Ac

2012
Anandamide protects from low serum-induced apoptosis via its degradation to ethanolamine.
    The Journal of biological chemistry, 2007, Mar-16, Volume: 282, Issue:11

    Topics: Amidohydrolases; Animals; Apoptosis; Arachidonic Acids; Caspase 3; Caspase 7; Cell Line, Tumor; DNA

2007
Stimulation of anandamide biosynthesis in N-18TG2 neuroblastoma cells by delta 9-tetrahydrocannabinol (THC).
    Biochemical pharmacology, 1995, Mar-15, Volume: 49, Issue:6

    Topics: Arachidonic Acid; Arachidonic Acids; Chromatography, Thin Layer; Dronabinol; Endocannabinoids; Ethan

1995
Evidence for indirect utilization of glycine for production of N-bases of glycerophospholipids and sphingolipids in mouse neuroblastoma cells by using 15N-labeled glycine.
    Biochemical and biophysical research communications, 1995, May-05, Volume: 210, Issue:1

    Topics: Animals; Cell Line; Choline; Ethanolamine; Ethanolamines; Glycine; Mice; Neuroblastoma; Phosphatidic

1995
The conversion of ethanolamine and of its metabolites to choline in human neuroblastoma clones: effect of differentiation induced by retinoic acid.
    Neurochemical research, 1994, Volume: 19, Issue:4

    Topics: Biological Transport; Cell Differentiation; Choline; Clone Cells; Ethanol; Ethanolamine; Ethanolamin

1994
Incorporation of [3H]ethanolamine into acetylcholine by a human cholinergic neuroblastoma clone.
    Neurochemical research, 1994, Volume: 19, Issue:1

    Topics: Acetylcholine; Choline; Clone Cells; Ethanolamine; Ethanolamines; Humans; Kinetics; Neuroblastoma; P

1994
Possible involvement of the base exchange enzymes in the phospholipid metabolism in LAN-2 cells.
    Italian journal of neurological sciences, 1993, Volume: 14, Issue:3

    Topics: Choline; Ethanolamine; Ethanolamines; Humans; Neuroblastoma; Phospholipids; Serine; Tetradecanoylpho

1993
Effects of differentiation on the phospholipid and phospholipid fatty acid composition of N1E-115 neuroblastoma cells.
    Biochimica et biophysica acta, 1993, Apr-07, Volume: 1167, Issue:2

    Topics: Cell Differentiation; Choline; Ethanolamine; Ethanolamines; Fatty Acids; Humans; Neuroblastoma; Phos

1993
Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells.
    The Biochemical journal, 1996, Jun-15, Volume: 316 ( Pt 3)

    Topics: Animals; Arachidonic Acids; Cannabinoids; Carbon Radioisotopes; Cell Line; Chromatography, High Pres

1996
Ethanol potentiates the uptake of [14C]serine into phosphatidylserine by base-exchange reaction in NG 108-15 cells.
    Neurochemical research, 1996, Volume: 21, Issue:3

    Topics: Animals; Carbon Radioisotopes; Choline; Ethanol; Ethanolamine; Ethanolamines; Glioma; Hybrid Cells;

1996
Hemicholinium-3 derivatives A-4 and A-5 alter choline metabolism in NB41A3 neuroblastoma cells.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1

    Topics: Animals; Biphenyl Compounds; Choline; Ethanolamine; Ethanolamines; Mice; Neuroblastoma; Phosphatidyl

1991
Alterations of phospholipid metabolism by phorbol esters and fatty acids occur by different intracellular mechanisms in cultured glioma, neuroblastoma, and hybrid cells.
    The Journal of biological chemistry, 1989, Feb-15, Volume: 264, Issue:5

    Topics: Animals; Cell Line; Choline; Ethanolamine; Ethanolamines; Fatty Acids; Glioma; Hybrid Cells; Kinetic

1989
myo-Inositol metabolism in 41A3 neuroblastoma cells: effects of high glucose and sorbitol levels.
    Journal of neurochemistry, 1987, Volume: 48, Issue:1

    Topics: Animals; Cell Division; Cell Line; Choline; Ethanolamine; Ethanolamines; Glucose; Inositol; Kinetics

1987
Phosphatidylcholine biosynthesis in the neuroblastoma-glioma hybrid cell line NG108-15: stimulation by phorbol esters.
    Journal of neurochemistry, 1986, Volume: 47, Issue:6

    Topics: Animals; Cell Line; Choline; Ethanolamine; Ethanolamines; Glioma; Inositol; Neuroblastoma; Phorbol E

1986
chemdatabank.com