ethacrynic acid and Cholera
ethacrynic acid has been researched along with Cholera in 7 studies
Ethacrynic Acid: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
etacrynic acid : An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Cholera: An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ethacrynic acid (EA) has been reported to reduce cholera toxin-induced intestinal fluid secretion in the intact animal." | 3.65 | Reversal of cyclic AMP-mediated intestinal secretion by ethacrynic acid. ( al-Awqati, Q; Field, M; Greenough, WB, 1974) |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Pierce, NF | 1 |
| Greenough, WB | 3 |
| Carpenter, CC | 2 |
| al-Awqati, Q | 1 |
| Field, M | 1 |
| Sladen, GE | 1 |
| Boyle, JM | 1 |
| Gardner, JD | 1 |
| Jacoby, HI | 1 |
| Marshall, CH | 1 |
| Lexomboon, U | 1 |
| Goth, A | 1 |
| Finkelstein, RA | 1 |
| Curlin, GT | 1 |
Reviews
2 reviews available for ethacrynic acid and Cholera
| Article | Year |
|---|---|
Vibrio cholerae enterotoxin and its mode of action.
Topics: Alkaline Phosphatase; Animals; Antacids; Biological Transport, Active; Capillary Permeability; Cell | 1971 |
The pathogenesis of cholera and some wider implications.
Topics: Acetazolamide; Amphotericin B; Animals; Cholera; Cyclic AMP; Diarrhea; Dogs; Duodenum; Escherichia c | 1973 |
Other Studies
5 other studies available for ethacrynic acid and Cholera
| Article | Year |
|---|---|
Reversal of cyclic AMP-mediated intestinal secretion by ethacrynic acid.
Topics: Animals; Biological Transport; Chlorides; Cholera; Cyclic AMP; Enterotoxins; Ethacrynic Acid; Ileum; | 1974 |
Sequence of events mediating the effect of cholera toxin on rat thymocytes.
Topics: Aminoisobutyric Acids; Animals; Calcium; Cholera; Cyclic AMP; Cycloheximide; Epinephrine; Ethacrynic | 1974 |
Antagonism of cholera enterotoxin by anti-inflammatory agents in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Body Fluids; Body Weight; Cholera; | 1972 |
Applications of the mouse foot edema test in evaluation of anti-cholera drugs.
Topics: Animals; Anti-Infective Agents; Aspirin; Chloramphenicol; Cholera; Cycloheximide; Dactinomycin; Diur | 1971 |
Response of canine Thiry-Vella jejunal loops to cholera exotoxin and its modification by ethacrynic acid.
Topics: Animals; Catheterization; Cholera; Dogs; Enterotoxins; Ethacrynic Acid; Furosemide; Injections, Intr | 1969 |