emodin and Sepsis
emodin has been researched along with Sepsis in 18 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emodin exerts protective effects on lung injury in septic rats, which is related to the inhibition of p38 MAPK pathway and the reduction of oxidative stress and inflammation response during sepsis." | 7.83 | Emodin alleviates lung injury in rats with sepsis. ( Chen, Y; Fu, HY; Liu, DD; Wan, B; Wan, SX; Wan, Y; Yin, JT; Zhang, H, 2016) |
| "Emodin is an anthraquinone derived from Chinese herb that exerts anti-inflammation effects." | 7.83 | Emodin alleviates jejunum injury in rats with sepsis by inhibiting inflammation response. ( Chen, YK; Fan, X; Fu, HY; Liu, DD; Wan, B; Xu, YK; Yin, JT; Zhang, H, 2016) |
| "To investigate the effects of emodin on aquaporin 5 (AQP5) expression in rats with sepsis-induced acute lung injury." | 7.81 | Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury. ( Cheng, J; Liu, J; Liu, S; Song, J; Sun, L; Sun, Y, 2015) |
| "To investigate the impact of monocyte releasing tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) stimulated by lipopolysaccharide (LPS) in severe sepsis (SS) patients, and the regulatory effect of emodin and Shenmai Injection (SMI) on monocyte response." | 7.73 | [Monocyte response and regulatory effect of emodin and shenmai injection on it in patients with severe sepsis]. ( Cui, NQ; Wang, GL; Yu, YH, 2006) |
| "Emodin (Emo) has received much attention for its notable anti-inflammatory and antibacterial properties." | 5.91 | Emodin protects against intestinal dysfunction and enhances survival in rat model of septic peritonitis through anti-inflammatory actions. ( Chen, W; Hua, Z; Li, W; Shen, J; Wang, Y, 2023) |
| "Emodin was found to upregulate AQP and TJ expression in the CLP model." | 5.56 | Emodin attenuates acute lung injury in Cecal-ligation and puncture rats. ( Guo, R; Han, M; Li, Y; Liu, J; Sun, Y, 2020) |
| "Emodin exerts protective effects on lung injury in septic rats, which is related to the inhibition of p38 MAPK pathway and the reduction of oxidative stress and inflammation response during sepsis." | 3.83 | Emodin alleviates lung injury in rats with sepsis. ( Chen, Y; Fu, HY; Liu, DD; Wan, B; Wan, SX; Wan, Y; Yin, JT; Zhang, H, 2016) |
| "Emodin is an anthraquinone derived from Chinese herb that exerts anti-inflammation effects." | 3.83 | Emodin alleviates jejunum injury in rats with sepsis by inhibiting inflammation response. ( Chen, YK; Fan, X; Fu, HY; Liu, DD; Wan, B; Xu, YK; Yin, JT; Zhang, H, 2016) |
| "To investigate the effects of emodin on aquaporin 5 (AQP5) expression in rats with sepsis-induced acute lung injury." | 3.81 | Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury. ( Cheng, J; Liu, J; Liu, S; Song, J; Sun, L; Sun, Y, 2015) |
| "To investigate the impact of monocyte releasing tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) stimulated by lipopolysaccharide (LPS) in severe sepsis (SS) patients, and the regulatory effect of emodin and Shenmai Injection (SMI) on monocyte response." | 3.73 | [Monocyte response and regulatory effect of emodin and shenmai injection on it in patients with severe sepsis]. ( Cui, NQ; Wang, GL; Yu, YH, 2006) |
| "Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years." | 3.01 | Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis. ( Su, J; Tong, Z; Wu, S; Zhou, F, 2023) |
| " Next, the bioavailability of active ingredients (Rhein, Emodin and Aloe emodin) in R." | 1.91 | UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang. ( Chen, Q; Fang, B; Feng, L; Huo, X; Lv, X; Ma, X; Mei, Q; Sun, C; Tian, X; Wang, C; Wang, Y; Wu, F; Zhang, Y, 2023) |
| "Emodin (Emo) has received much attention for its notable anti-inflammatory and antibacterial properties." | 1.91 | Emodin protects against intestinal dysfunction and enhances survival in rat model of septic peritonitis through anti-inflammatory actions. ( Chen, W; Hua, Z; Li, W; Shen, J; Wang, Y, 2023) |
| "Emodin is a natural anthraquinone derivative in many plants with promising bioactivities." | 1.72 | Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice. ( Bai, Y; Guo, Y; He, S; Lian, B; Lin, Y; Liu, Q; Wang, N; Wang, X; Xu, X; Zhang, M; Zhang, R; Zhao, J, 2022) |
| "Emodin was found to upregulate AQP and TJ expression in the CLP model." | 1.56 | Emodin attenuates acute lung injury in Cecal-ligation and puncture rats. ( Guo, R; Han, M; Li, Y; Liu, J; Sun, Y, 2020) |
Research
Studies (18)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 9 (50.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Liu, FJ | 1 |
| Gu, TJ | 1 |
| Wei, DY | 1 |
| Zhang, M | 1 |
| Lian, B | 1 |
| Zhang, R | 1 |
| Guo, Y | 1 |
| Zhao, J | 1 |
| He, S | 1 |
| Bai, Y | 1 |
| Wang, N | 1 |
| Lin, Y | 1 |
| Wang, X | 1 |
| Liu, Q | 1 |
| Xu, X | 1 |
| Wu, F | 1 |
| Wang, Y | 2 |
| Mei, Q | 1 |
| Chen, Q | 2 |
| Sun, C | 1 |
| Lv, X | 1 |
| Feng, L | 1 |
| Wang, C | 1 |
| Zhang, Y | 1 |
| Fang, B | 1 |
| Huo, X | 1 |
| Tian, X | 1 |
| Ma, X | 1 |
| Su, J | 2 |
| Chen, S | 1 |
| Xiao, J | 1 |
| Feng, Z | 1 |
| Hu, S | 1 |
| Su, Q | 1 |
| Chen, D | 1 |
| Zhou, F | 1 |
| Wu, S | 1 |
| Tong, Z | 1 |
| Hua, Z | 1 |
| Chen, W | 1 |
| Li, W | 1 |
| Shen, J | 1 |
| Guo, R | 1 |
| Li, Y | 1 |
| Han, M | 1 |
| Liu, J | 2 |
| Sun, Y | 2 |
| Fan, TT | 1 |
| Cheng, BL | 1 |
| Fang, XM | 1 |
| Chen, YC | 1 |
| Su, F | 1 |
| Dai, S | 1 |
| Ye, B | 1 |
| Chen, L | 1 |
| Hong, G | 1 |
| Zhao, G | 1 |
| Lu, Z | 1 |
| Fu, WJ | 1 |
| Tang, JJ | 1 |
| Wang, H | 1 |
| Wei, HY | 1 |
| Cai, SM | 1 |
| Zeng, ZH | 1 |
| Chen, H | 1 |
| Chen, ZQ | 1 |
| Lee, W | 3 |
| Jeong, GS | 1 |
| Baek, MC | 1 |
| Ku, SK | 3 |
| Bae, JS | 3 |
| Sun, L | 1 |
| Liu, S | 1 |
| Song, J | 1 |
| Cheng, J | 2 |
| Yin, JT | 2 |
| Wan, B | 2 |
| Liu, DD | 2 |
| Wan, SX | 1 |
| Fu, HY | 2 |
| Wan, Y | 1 |
| Zhang, H | 2 |
| Chen, Y | 2 |
| Chen, YK | 1 |
| Xu, YK | 1 |
| Fan, X | 1 |
| Liu, X | 1 |
| Zheng, X | 1 |
| Wu, C | 1 |
| Li, B | 1 |
| Fu, J | 1 |
| Cao, H | 1 |
| Lu, Y | 1 |
| Li, J | 1 |
| Zheng, J | 1 |
| Zhou, H | 1 |
| Kim, TH | 1 |
| Yu, YH | 1 |
| Cui, NQ | 1 |
| Wang, GL | 1 |
Reviews
2 reviews available for emodin and Sepsis
| Article | Year |
|---|---|
Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis.
Topics: Biomedical Research; Emodin; Ginsenosides; Humans; Immunosuppression Therapy; Sepsis | 2023 |
Application of Chinese Medicine in the Management of Critical Conditions: A Review on Sepsis.
Topics: Anti-Inflammatory Agents; Artemisinins; Astragalus propinquus; Berberine; Betacoronavirus; Coronavir | 2020 |
Other Studies
16 other studies available for emodin and Sepsis
| Article | Year |
|---|---|
Emodin alleviates sepsis-mediated lung injury via inhibition and reduction of NF-kB and HMGB1 pathways mediated by SIRT1.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage; Cell Line; Emodin; HMGB1 Protein; Interleukin-1b | 2022 |
Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice.
Topics: Animals; Emodin; Gastrointestinal Microbiome; Intestinal Mucosa; Lipopolysaccharides; Mice; NF-kappa | 2022 |
UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang.
Topics: Animals; Anti-Inflammatory Agents; COVID-19; Emodin; Humans; Lipopolysaccharides; Mice; Rats; Sepsis | 2023 |
Aloe-Emodin Ameliorates Cecal Ligation and Puncture-Induced Sepsis.
Topics: Aloe; Animals; Anti-Inflammatory Agents; Cecum; Disease Models, Animal; Emodin; Ligation; Mice; Punc | 2023 |
Emodin protects against intestinal dysfunction and enhances survival in rat model of septic peritonitis through anti-inflammatory actions.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Emodin; Peritonitis; Rats; Rats, Sprague-Dawley; S | 2023 |
Emodin attenuates acute lung injury in Cecal-ligation and puncture rats.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Aquaporin 1; Aquaporin 5; Cecum; Cl | 2020 |
Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation.
Topics: Animals; Emodin; Heart; Inflammasomes; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Myocardium; My | 2021 |
In vivo and in vitro anti-sepsis effects of physcion 8-O-β-glucopyranoside extracted from Rumex japonicus.
Topics: Animals; Anti-Inflammatory Agents; Drugs, Chinese Herbal; Emodin; Glucosides; Humans; Interleukin-1b | 2017 |
Renal protective effects of aloin in a mouse model of sepsis.
Topics: Animals; Cell Line; Emodin; I-kappa B Proteins; Interleukin-6; Kidney; Kidney Diseases; Lipid Peroxi | 2019 |
Emodin-6-O-β-D-glucoside down-regulates endothelial protein C receptor shedding.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Cells | 2013 |
Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Aquaporin 5; Disease Models, Animal; Down-Regulation; Emodin; Humans; Lu | 2015 |
Emodin alleviates lung injury in rats with sepsis.
Topics: Animals; Biomarkers; Blotting, Western; Emodin; Enzyme-Linked Immunosorbent Assay; Injections, Intra | 2016 |
Emodin alleviates jejunum injury in rats with sepsis by inhibiting inflammation response.
Topics: Animals; Apoptosis; Calcitonin; Emodin; In Situ Nick-End Labeling; Inflammation; Interleukin-6; Inte | 2016 |
Targeting CpG DNA to screen and isolate anti-sepsis fraction and monomers from traditional Chinese herbs using affinity biosensor technology.
Topics: Aconitum; Animals; Anthraquinones; Biosensing Techniques; Cell Line; Chemical Fractionation; Chromat | 2009 |
Emodin-6-O-β-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Cell Adhesion; Cell Movement; Cytoskeleton; | 2013 |
[Monocyte response and regulatory effect of emodin and shenmai injection on it in patients with severe sepsis].
Topics: Adult; Drug Combinations; Drugs, Chinese Herbal; Emodin; Humans; Immunologic Factors; Injections; In | 2006 |