Page last updated: 2024-10-26

emodin and Sepsis

emodin has been researched along with Sepsis in 18 studies

Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"Emodin exerts protective effects on lung injury in septic rats, which is related to the inhibition of p38 MAPK pathway and the reduction of oxidative stress and inflammation response during sepsis."7.83Emodin alleviates lung injury in rats with sepsis. ( Chen, Y; Fu, HY; Liu, DD; Wan, B; Wan, SX; Wan, Y; Yin, JT; Zhang, H, 2016)
"Emodin is an anthraquinone derived from Chinese herb that exerts anti-inflammation effects."7.83Emodin alleviates jejunum injury in rats with sepsis by inhibiting inflammation response. ( Chen, YK; Fan, X; Fu, HY; Liu, DD; Wan, B; Xu, YK; Yin, JT; Zhang, H, 2016)
"To investigate the effects of emodin on aquaporin 5 (AQP5) expression in rats with sepsis-induced acute lung injury."7.81Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury. ( Cheng, J; Liu, J; Liu, S; Song, J; Sun, L; Sun, Y, 2015)
"To investigate the impact of monocyte releasing tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) stimulated by lipopolysaccharide (LPS) in severe sepsis (SS) patients, and the regulatory effect of emodin and Shenmai Injection (SMI) on monocyte response."7.73[Monocyte response and regulatory effect of emodin and shenmai injection on it in patients with severe sepsis]. ( Cui, NQ; Wang, GL; Yu, YH, 2006)
"Emodin (Emo) has received much attention for its notable anti-inflammatory and antibacterial properties."5.91Emodin protects against intestinal dysfunction and enhances survival in rat model of septic peritonitis through anti-inflammatory actions. ( Chen, W; Hua, Z; Li, W; Shen, J; Wang, Y, 2023)
"Emodin was found to upregulate AQP and TJ expression in the CLP model."5.56Emodin attenuates acute lung injury in Cecal-ligation and puncture rats. ( Guo, R; Han, M; Li, Y; Liu, J; Sun, Y, 2020)
"Emodin exerts protective effects on lung injury in septic rats, which is related to the inhibition of p38 MAPK pathway and the reduction of oxidative stress and inflammation response during sepsis."3.83Emodin alleviates lung injury in rats with sepsis. ( Chen, Y; Fu, HY; Liu, DD; Wan, B; Wan, SX; Wan, Y; Yin, JT; Zhang, H, 2016)
"Emodin is an anthraquinone derived from Chinese herb that exerts anti-inflammation effects."3.83Emodin alleviates jejunum injury in rats with sepsis by inhibiting inflammation response. ( Chen, YK; Fan, X; Fu, HY; Liu, DD; Wan, B; Xu, YK; Yin, JT; Zhang, H, 2016)
"To investigate the effects of emodin on aquaporin 5 (AQP5) expression in rats with sepsis-induced acute lung injury."3.81Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury. ( Cheng, J; Liu, J; Liu, S; Song, J; Sun, L; Sun, Y, 2015)
"To investigate the impact of monocyte releasing tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) stimulated by lipopolysaccharide (LPS) in severe sepsis (SS) patients, and the regulatory effect of emodin and Shenmai Injection (SMI) on monocyte response."3.73[Monocyte response and regulatory effect of emodin and shenmai injection on it in patients with severe sepsis]. ( Cui, NQ; Wang, GL; Yu, YH, 2006)
"Sepsis is a serious disease with high mortality and has been a hot research topic in medical research in recent years."3.01Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis. ( Su, J; Tong, Z; Wu, S; Zhou, F, 2023)
" Next, the bioavailability of active ingredients (Rhein, Emodin and Aloe emodin) in R."1.91UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang. ( Chen, Q; Fang, B; Feng, L; Huo, X; Lv, X; Ma, X; Mei, Q; Sun, C; Tian, X; Wang, C; Wang, Y; Wu, F; Zhang, Y, 2023)
"Emodin (Emo) has received much attention for its notable anti-inflammatory and antibacterial properties."1.91Emodin protects against intestinal dysfunction and enhances survival in rat model of septic peritonitis through anti-inflammatory actions. ( Chen, W; Hua, Z; Li, W; Shen, J; Wang, Y, 2023)
"Emodin is a natural anthraquinone derivative in many plants with promising bioactivities."1.72Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice. ( Bai, Y; Guo, Y; He, S; Lian, B; Lin, Y; Liu, Q; Wang, N; Wang, X; Xu, X; Zhang, M; Zhang, R; Zhao, J, 2022)
"Emodin was found to upregulate AQP and TJ expression in the CLP model."1.56Emodin attenuates acute lung injury in Cecal-ligation and puncture rats. ( Guo, R; Han, M; Li, Y; Liu, J; Sun, Y, 2020)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (11.11)29.6817
2010's7 (38.89)24.3611
2020's9 (50.00)2.80

Authors

AuthorsStudies
Liu, FJ1
Gu, TJ1
Wei, DY1
Zhang, M1
Lian, B1
Zhang, R1
Guo, Y1
Zhao, J1
He, S1
Bai, Y1
Wang, N1
Lin, Y1
Wang, X1
Liu, Q1
Xu, X1
Wu, F1
Wang, Y2
Mei, Q1
Chen, Q2
Sun, C1
Lv, X1
Feng, L1
Wang, C1
Zhang, Y1
Fang, B1
Huo, X1
Tian, X1
Ma, X1
Su, J2
Chen, S1
Xiao, J1
Feng, Z1
Hu, S1
Su, Q1
Chen, D1
Zhou, F1
Wu, S1
Tong, Z1
Hua, Z1
Chen, W1
Li, W1
Shen, J1
Guo, R1
Li, Y1
Han, M1
Liu, J2
Sun, Y2
Fan, TT1
Cheng, BL1
Fang, XM1
Chen, YC1
Su, F1
Dai, S1
Ye, B1
Chen, L1
Hong, G1
Zhao, G1
Lu, Z1
Fu, WJ1
Tang, JJ1
Wang, H1
Wei, HY1
Cai, SM1
Zeng, ZH1
Chen, H1
Chen, ZQ1
Lee, W3
Jeong, GS1
Baek, MC1
Ku, SK3
Bae, JS3
Sun, L1
Liu, S1
Song, J1
Cheng, J2
Yin, JT2
Wan, B2
Liu, DD2
Wan, SX1
Fu, HY2
Wan, Y1
Zhang, H2
Chen, Y2
Chen, YK1
Xu, YK1
Fan, X1
Liu, X1
Zheng, X1
Wu, C1
Li, B1
Fu, J1
Cao, H1
Lu, Y1
Li, J1
Zheng, J1
Zhou, H1
Kim, TH1
Yu, YH1
Cui, NQ1
Wang, GL1

Reviews

2 reviews available for emodin and Sepsis

ArticleYear
Research Progress on Natural Small-Molecule Compounds for the Prevention and Treatment of Sepsis.
    International journal of molecular sciences, 2023, Aug-12, Volume: 24, Issue:16

    Topics: Biomedical Research; Emodin; Ginsenosides; Humans; Immunosuppression Therapy; Sepsis

2023
Application of Chinese Medicine in the Management of Critical Conditions: A Review on Sepsis.
    The American journal of Chinese medicine, 2020, Volume: 48, Issue:6

    Topics: Anti-Inflammatory Agents; Artemisinins; Astragalus propinquus; Berberine; Betacoronavirus; Coronavir

2020

Other Studies

16 other studies available for emodin and Sepsis

ArticleYear
Emodin alleviates sepsis-mediated lung injury via inhibition and reduction of NF-kB and HMGB1 pathways mediated by SIRT1.
    The Kaohsiung journal of medical sciences, 2022, Volume: 38, Issue:3

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage; Cell Line; Emodin; HMGB1 Protein; Interleukin-1b

2022
Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice.
    Mediators of inflammation, 2022, Volume: 2022

    Topics: Animals; Emodin; Gastrointestinal Microbiome; Intestinal Mucosa; Lipopolysaccharides; Mice; NF-kappa

2022
UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang.
    Journal of ethnopharmacology, 2023, Mar-25, Volume: 304

    Topics: Animals; Anti-Inflammatory Agents; COVID-19; Emodin; Humans; Lipopolysaccharides; Mice; Rats; Sepsis

2023
Aloe-Emodin Ameliorates Cecal Ligation and Puncture-Induced Sepsis.
    International journal of molecular sciences, 2023, Jul-26, Volume: 24, Issue:15

    Topics: Aloe; Animals; Anti-Inflammatory Agents; Cecum; Disease Models, Animal; Emodin; Ligation; Mice; Punc

2023
Emodin protects against intestinal dysfunction and enhances survival in rat model of septic peritonitis through anti-inflammatory actions.
    Immunity, inflammation and disease, 2023, Volume: 11, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Emodin; Peritonitis; Rats; Rats, Sprague-Dawley; S

2023
Emodin attenuates acute lung injury in Cecal-ligation and puncture rats.
    International immunopharmacology, 2020, Volume: 85

    Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Aquaporin 1; Aquaporin 5; Cecum; Cl

2020
Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation.
    Phytotherapy research : PTR, 2021, Volume: 35, Issue:9

    Topics: Animals; Emodin; Heart; Inflammasomes; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Myocardium; My

2021
In vivo and in vitro anti-sepsis effects of physcion 8-O-β-glucopyranoside extracted from Rumex japonicus.
    Chinese journal of natural medicines, 2017, Volume: 15, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Drugs, Chinese Herbal; Emodin; Glucosides; Humans; Interleukin-1b

2017
Renal protective effects of aloin in a mouse model of sepsis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 132

    Topics: Animals; Cell Line; Emodin; I-kappa B Proteins; Interleukin-6; Kidney; Kidney Diseases; Lipid Peroxi

2019
Emodin-6-O-β-D-glucoside down-regulates endothelial protein C receptor shedding.
    Archives of pharmacal research, 2013, Volume: 36, Issue:9

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Cells

2013
Effect of emodin on Aquaporin 5 expression in rats with sepsis-induced acute lung injury.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2015, Volume: 35, Issue:6

    Topics: Acute Lung Injury; Animals; Aquaporin 5; Disease Models, Animal; Down-Regulation; Emodin; Humans; Lu

2015
Emodin alleviates lung injury in rats with sepsis.
    The Journal of surgical research, 2016, 05-15, Volume: 202, Issue:2

    Topics: Animals; Biomarkers; Blotting, Western; Emodin; Enzyme-Linked Immunosorbent Assay; Injections, Intra

2016
Emodin alleviates jejunum injury in rats with sepsis by inhibiting inflammation response.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Animals; Apoptosis; Calcitonin; Emodin; In Situ Nick-End Labeling; Inflammation; Interleukin-6; Inte

2016
Targeting CpG DNA to screen and isolate anti-sepsis fraction and monomers from traditional Chinese herbs using affinity biosensor technology.
    International immunopharmacology, 2009, Volume: 9, Issue:9

    Topics: Aconitum; Animals; Anthraquinones; Biosensing Techniques; Cell Line; Chemical Fractionation; Chromat

2009
Emodin-6-O-β-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 52

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Cell Adhesion; Cell Movement; Cytoskeleton;

2013
[Monocyte response and regulatory effect of emodin and shenmai injection on it in patients with severe sepsis].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2006, Volume: 26 Suppl

    Topics: Adult; Drug Combinations; Drugs, Chinese Herbal; Emodin; Humans; Immunologic Factors; Injections; In

2006