e 4031 and Heart Failure
e 4031 has been researched along with Heart Failure in 4 studies
E 4031: class III anti-arrhythmia agent; structure given in UD
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of E 4031, a sodium calcium exchanger (NCX) agonist, on the isolated cardiac function and resting Ca2+ level in myocardial cells from rats with chronic heart failure." | 7.80 | [Effects of E 4031 on isolated cardiac function and resting Ca2+ level of myocardial cells from rats with chronic heart failure]. ( Bai, XJ; Hao, JT, 2014) |
| "To investigate the effects of E 4031, a sodium calcium exchanger (NCX) agonist, on the isolated cardiac function and resting Ca2+ level in myocardial cells from rats with chronic heart failure." | 3.80 | [Effects of E 4031 on isolated cardiac function and resting Ca2+ level of myocardial cells from rats with chronic heart failure]. ( Bai, XJ; Hao, JT, 2014) |
| "The effects of congestive heart failure (CHF) on the ionic properties of PCs are unknown." | 1.31 | Ionic remodeling of cardiac Purkinje cells by congestive heart failure. ( Chartier, D; Han, W; Li, D; Nattel, S, 2001) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bai, XJ | 1 |
| Hao, JT | 1 |
| Holzem, KM | 1 |
| Gomez, JF | 1 |
| Glukhov, AV | 1 |
| Madden, EJ | 1 |
| Koppel, AC | 1 |
| Ewald, GA | 1 |
| Trenor, B | 1 |
| Efimov, IR | 1 |
| Tsuji, Y | 1 |
| Opthof, T | 1 |
| Kamiya, K | 1 |
| Yasui, K | 1 |
| Liu, W | 1 |
| Lu, Z | 1 |
| Kodama, I | 1 |
| Han, W | 1 |
| Chartier, D | 1 |
| Li, D | 1 |
| Nattel, S | 1 |
Other Studies
4 other studies available for e 4031 and Heart Failure
| Article | Year |
|---|---|
[Effects of E 4031 on isolated cardiac function and resting Ca2+ level of myocardial cells from rats with chronic heart failure].
Topics: Animals; Calcium; Disease Models, Animal; Heart; Heart Failure; In Vitro Techniques; Male; Myocardiu | 2014 |
Reduced response to IKr blockade and altered hERG1a/1b stoichiometry in human heart failure.
Topics: Action Potentials; Adolescent; Adult; Anti-Arrhythmia Agents; Computer Simulation; ERG1 Potassium Ch | 2016 |
Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channels, L-Type; Cardiac Pacing, Artifi | 2000 |
Ionic remodeling of cardiac Purkinje cells by congestive heart failure.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Barium; Calcium; Calcium Channels, L-Type; Calci | 2001 |