Page last updated: 2024-10-26

donepezil and Tics

donepezil has been researched along with Tics in 1 studies

Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.

Tics: Habitual, repeated, rapid contraction of certain muscles, resulting in stereotyped individualized actions that can be voluntarily suppressed for only brief periods. They often involve the face, vocal cords, neck, and less often the extremities. Examples include repetitive throat clearing, vocalizations, sniffing, pursing the lips, and excessive blinking. Tics tend to be aggravated by emotional stress. When frequent they may interfere with speech and INTERPERSONAL RELATIONS. Conditions which feature frequent and prominent tics as a primary manifestation of disease are referred to as TIC DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, pp109-10)

Research Excerpts

ExcerptRelevanceReference
"Donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate Alzheimer's disease."5.32Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. ( Hayslett, RL; Tizabi, Y, 2003)
"Donepezil is an acetylcholinesterase inhibitor approved for use in mild to moderate Alzheimer's disease."1.32Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome. ( Hayslett, RL; Tizabi, Y, 2003)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hayslett, RL1
Tizabi, Y1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pilot Examination of Galantamine in the Management of Tic Disorders[NCT00226824]Phase 41 participants (Actual)Interventional2005-09-30Terminated (stopped due to Unable to recruit subjects into the trial.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

1 other study available for donepezil and Tics

ArticleYear
Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 76, Issue:3-4

    Topics: Amphetamines; Animals; Donepezil; Drug Synergism; Head Movements; Indans; Male; Mecamylamine; Mice;

2003