donepezil has been researched along with Emesis in 12 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this 10-week, randomized, double-blind, placebo-controlled multicenter study was to assess the efficacy and safety of donepezil for the treatment of cognitive dysfunction exhibited by children with Down syndrome (DS)." | 9.14 | Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17. ( Escobar, L; Heller, JH; Kishnani, PS; Lott, I; McRae, T; Richardson, S; Spiridigliozzi, GA; Zhang, R, 2010) |
| "Even after a single-tablet ingestion, donepezil may cause prolonged altered mental status and bradycardia in young children." | 7.80 | Prolonged altered mental status and bradycardia following pediatric donepezil ingestion. ( Balakrishnan, K; Fong, J; Garlich, FM; Howland, MA; Nelson, LS; Shah, SK, 2014) |
| "The objective of this 10-week, randomized, double-blind, placebo-controlled multicenter study was to assess the efficacy and safety of donepezil for the treatment of cognitive dysfunction exhibited by children with Down syndrome (DS)." | 5.14 | Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17. ( Escobar, L; Heller, JH; Kishnani, PS; Lott, I; McRae, T; Richardson, S; Spiridigliozzi, GA; Zhang, R, 2010) |
| "Donepezil, an acetylcholinesterase inhibitor, is associated with gastrointestinal symptoms, such as nausea, vomiting, and anorexia, which may affect adherence to continuous therapy." | 4.12 | Effects of Rikkunshi-To, a Japanese kampo medicine, on donepezil-induced gastrointestinal side effects in mice. ( Hagihara, K; Jotaki, A; Kirikihira, K; Michihara, A; Miyake, Y; Sato, Y; Yamamoto, K, 2022) |
| "Even after a single-tablet ingestion, donepezil may cause prolonged altered mental status and bradycardia in young children." | 3.80 | Prolonged altered mental status and bradycardia following pediatric donepezil ingestion. ( Balakrishnan, K; Fong, J; Garlich, FM; Howland, MA; Nelson, LS; Shah, SK, 2014) |
| " Experiment 1 tested the effects of 5 mg/per day dosage on cognitive and EEG markers at 6-hour, 2-week and 4-week follow-ups." | 2.76 | Donepezil impairs memory in healthy older subjects: behavioural, EEG and simultaneous EEG/fMRI biomarkers. ( Balsters, JH; Bokde, AL; Brennan, S; Cassidy, SM; Delmonte, S; Fagan, AJ; Galli, A; Kilcullen, SM; Lai, R; Laruelle, M; Lawlor, B; Martin, MP; Meaney, JF; O'Connell, RG; Robertson, IH; Upton, N, 2011) |
| "Donepezil (Aricept) is a highly selective acetylcholinesterase inhibitors with a pharmacokinetic profile allowing once-daily dosing." | 2.42 | Donepezil (Aricept) for treatment of Alzheimer's disease and other dementing conditions. ( Geldmacher, DS, 2004) |
| "The objective was to investigate the frequency of adverse events (AE) as a cause for discontinuation of donepezil treatment for Alzheimer's dementia (DAT) in a geriatric memory unit." | 1.35 | [Adverse events causing discontinuation of donepezil for Alzheimer's dementia]. ( Carøe, TK; Moe, C, 2009) |
| " It is important to prevent dosing errors in cooperation with medical providers, patients and families." | 1.32 | [A case of acute cholinergic adverse effects induced by donepezil overdose: a follow-up of clinical course and plasma concentration of donepezil]. ( Fukuhara, Y; Kowa, H; Nakashima, K; Wada, K; Yano, H, 2003) |
| "Donepezil is an acetylcholinesterase inhibitor indicated for the symptomatic treatment of mild to moderate Alzheimer's disease." | 1.31 | Adverse effects associated with the use of donepezil in general practice in England. ( Dunn, NR; Pearce, GL; Shakir, SA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, J | 1 |
| Huang, YY | 1 |
| Zhou, Q | 1 |
| Gao, Y | 1 |
| Li, Z | 1 |
| Wu, D | 1 |
| Yu, S | 1 |
| Guo, L | 1 |
| Chen, Z | 1 |
| Huang, L | 1 |
| Liang, SH | 1 |
| He, X | 1 |
| Wu, R | 1 |
| Luo, HB | 1 |
| Yamamoto, K | 1 |
| Sato, Y | 1 |
| Hagihara, K | 1 |
| Kirikihira, K | 1 |
| Jotaki, A | 1 |
| Michihara, A | 1 |
| Miyake, Y | 1 |
| Davoren, JE | 1 |
| Garnsey, M | 1 |
| Pettersen, B | 1 |
| Brodney, MA | 1 |
| Edgerton, JR | 1 |
| Fortin, JP | 1 |
| Grimwood, S | 1 |
| Harris, AR | 1 |
| Jenkinson, S | 1 |
| Kenakin, T | 1 |
| Lazzaro, JT | 1 |
| Lee, CW | 1 |
| Lotarski, SM | 1 |
| Nottebaum, L | 1 |
| O'Neil, SV | 1 |
| Popiolek, M | 1 |
| Ramsey, S | 1 |
| Steyn, SJ | 1 |
| Thorn, CA | 1 |
| Zhang, L | 1 |
| Webb, D | 1 |
| Garlich, FM | 1 |
| Balakrishnan, K | 1 |
| Shah, SK | 1 |
| Howland, MA | 1 |
| Fong, J | 1 |
| Nelson, LS | 1 |
| Vanmierlo, T | 1 |
| Creemers, P | 1 |
| Akkerman, S | 1 |
| van Duinen, M | 1 |
| Sambeth, A | 1 |
| De Vry, J | 1 |
| Uz, T | 1 |
| Blokland, A | 1 |
| Prickaerts, J | 1 |
| Carøe, TK | 1 |
| Moe, C | 1 |
| Kishnani, PS | 1 |
| Heller, JH | 1 |
| Spiridigliozzi, GA | 1 |
| Lott, I | 1 |
| Escobar, L | 1 |
| Richardson, S | 1 |
| Zhang, R | 1 |
| McRae, T | 1 |
| Balsters, JH | 1 |
| O'Connell, RG | 1 |
| Martin, MP | 1 |
| Galli, A | 1 |
| Cassidy, SM | 1 |
| Kilcullen, SM | 1 |
| Delmonte, S | 1 |
| Brennan, S | 1 |
| Meaney, JF | 1 |
| Fagan, AJ | 1 |
| Bokde, AL | 1 |
| Upton, N | 1 |
| Lai, R | 1 |
| Laruelle, M | 1 |
| Lawlor, B | 1 |
| Robertson, IH | 1 |
| Yano, H | 1 |
| Fukuhara, Y | 1 |
| Wada, K | 1 |
| Kowa, H | 1 |
| Nakashima, K | 1 |
| Geldmacher, DS | 1 |
| Dunn, NR | 1 |
| Pearce, GL | 1 |
| Shakir, SA | 1 |
| Lam, W | 1 |
1 review available for donepezil and Emesis
| Article | Year |
|---|---|
Donepezil (Aricept) for treatment of Alzheimer's disease and other dementing conditions.
Topics: Alzheimer Disease; Anorexia; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorder | 2004 |
2 trials available for donepezil and Emesis
| Article | Year |
|---|---|
Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17.
Topics: Adolescent; Behavior; Caregivers; Child; Cholinesterase Inhibitors; Cognition Disorders; Diarrhea; D | 2010 |
Donepezil impairs memory in healthy older subjects: behavioural, EEG and simultaneous EEG/fMRI biomarkers.
Topics: Aged; Analysis of Variance; Cholinesterase Inhibitors; Cognition; Cross-Over Studies; Diarrhea; Done | 2011 |
9 other studies available for donepezil and Emesis
| Article | Year |
|---|---|
Discovery and Optimization of α-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia.
Topics: Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; De | 2020 |
Effects of Rikkunshi-To, a Japanese kampo medicine, on donepezil-induced gastrointestinal side effects in mice.
Topics: Acetylcholinesterase; Animals; Anorexia; Donepezil; Drugs, Chinese Herbal; Ghrelin; Humans; Kaolin; | 2022 |
Design and Synthesis of γ- and δ-Lactam M
Topics: Allosteric Regulation; Amphetamine; Animals; Ataxia; Diarrhea; Dogs; Donepezil; Drug Design; Female; | 2017 |
Prolonged altered mental status and bradycardia following pediatric donepezil ingestion.
Topics: Accidents, Home; Bradycardia; Cholinesterase Inhibitors; Donepezil; Emergency Service, Hospital; Hum | 2014 |
The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses.
Topics: Aminopyridines; Animals; Benzamides; Cyclopropanes; Donepezil; Indans; Male; Memory; Mice; Mice, Inb | 2016 |
[Adverse events causing discontinuation of donepezil for Alzheimer's dementia].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Appetite; Cholinesterase Inhibitors; Diarrhea; Donepezil | 2009 |
[A case of acute cholinergic adverse effects induced by donepezil overdose: a follow-up of clinical course and plasma concentration of donepezil].
Topics: Aged; Alzheimer Disease; Arrhythmia, Sinus; Bradycardia; Cholinesterase Inhibitors; Donepezil; Drug | 2003 |
Adverse effects associated with the use of donepezil in general practice in England.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Drug Prescriptions; E | 2000 |
Pharmacological treatment of cognitive deficits in Alzheimer's disease.
Topics: Alzheimer Disease; Diarrhea; Donepezil; Humans; Indans; Nausea; Nootropic Agents; Piperidines; Vomit | 2002 |