diflunisal has been researched along with Pain in 26 studies
Diflunisal: A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN.
diflunisal : An organofluorine compound comprising salicylic acid having a 2,4-difluorophenyl group at the 5-position.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of diflunisal in cancer pain was evaluated and compared with dipyrone." | 9.08 | A comparison of two nonsteroidal antiinflammatory drugs (diflunisal versus dipyrone) in the treatment of moderate to severe cancer pain: a randomized crossover study. ( Firat, D; Güllü, IH; Savaş, C; Tekuzman, G; Yalçin, S, 1998) |
| "The efficacy and tolerability of diflunisal (500 mg orally, twice daily) and piroxicam (20 mg orally, once daily) were compared in a 12-week open-label study in 44 patients with active rheumatoid arthritis." | 9.06 | Comparison of diflunisal and piroxicam in the management of patients with rheumatoid arthritis. ( Rice, DM, 1987) |
| "Fifty college athletes with acute sprains and strains from football-related activities were randomly assigned to treatment with either diflunisal or acetaminophen with codeine for seven days." | 9.06 | Comparison of diflunisal and acetaminophen with codeine in the treatment of mild to moderate pain due to strains and sprains. ( Indelicato, PA, 1986) |
| "Two nonsteroidal anti-inflammatory drugs, diflunisal and naproxen, were compared for efficacy in relieving anterior knee pain of mild to moderate severity." | 9.06 | Comparison of diflunisal and naproxen for relief of anterior knee pain. ( Folcik, MA; Fulkerson, JP, 1986) |
| "The efficacy and safety of diflunisal versus placebo in the treatment of pain were compared in a multicenter, double-blind study of 1,037 patients treated for seven days by general practitioners." | 9.05 | Diflunisal versus placebo for treatment of pain in general practice. ( Ageorges, P; Ankri, J; Chastang, JF; Fermanian, J; Lancrenon, S; Puech, A; Simon, P; Soubrie, C, 1982) |
| "A single-blind study was carried out in 52 patients with severe pain after Colles' fracture to assess the analgesic efficacy and tolerability of 500 mg diflunisal twice daily compared with that of 500 mg mefenamic acid given 3-times daily over a period of 5 days." | 9.05 | Single-blind study of diflunisal versus mefenamic acid in the treatment of pain after Colles' fracture. ( Barrington, R, 1980) |
| "A double-blind study of 43 patients undergoing excision of haemorrhoids under spinal anaesthesia was carried out to compare the analgesic effects of diflunisal (DFL, 21 patients) and dextropropoxyphene napsylate (DPN, 22 patients) on post-operative pain." | 9.05 | Comparison of diflunisal and dextropropoxyphene napsylate in the treatment of post-operative pain. ( Jalovaara, P; Kiviniemi, H; Ståhlberg, M, 1985) |
| "Diflunisal, a long acting antiinflammatory analgesic was compared in high (1000 mg daily) and low (750 mg daily) doses with placebo in a randomized, double blind study of 6 weeks' duration in patients with osteoarthritis of the knee." | 9.05 | The efficacy of diflunisal in osteoarthritis of the knee. A Canadian Multicenter Study. ( Davis, P; Lee, P; Prat, A, 1985) |
| "A randomized double-blind study in ambulatory patients with osteoarthritis of hip and/or knee was conducted, comparing the efficacy and safety of diflunisal 500 mg daily with ibuprofen 1200 mg daily, and a period of 8 weeks." | 9.04 | A comparative clinical trial of diflunisal and ibuprofen in the control of pain in osteoarthritis. ( Keet, JG, 1979) |
| "In an open study in patients with tumour-induced pain the analgetic effects of the prostaglandin-inhibiting compound diflunisal and the centrally-acting analgetic tilidine N were compared." | 7.67 | [Comparison of diflunisal and tilidine in tumor pain]. ( Brückle, W; Lydtin, H, 1984) |
| "The analgesic activity of diflunisal was evaluated through the measurement of cutaneous sensory and pain thresholds after electrical stimulation." | 7.67 | Effects of diflunisal on cutaneous sensory and pain thresholds. ( Dragani, L; Giamberardino, MA; Obletter, G; Vecchiet, L, 1988) |
| "Diflunisal was found to be an effective analgesic in mild to moderate pain of acute soft tissue injuries, and caused fewer and more tolerable side effects than did acetaminophen with codeine." | 6.66 | Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine. ( DeForge, B; King, DE; Muncie, HL, 1986) |
| "Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity." | 6.36 | Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| " Thus, the increase in diflunisal analgesic response in arthritis may be attributed to pharmacokinetic perturbations, resulting from alterations in serum protein binding and not to changes in drug pharmacodynamics." | 5.27 | Diflunisal pharmacodynamics in experimental arthritis in rats. ( Kasmerski, L; Walker, JS, 1988) |
| "The efficacy of diflunisal in cancer pain was evaluated and compared with dipyrone." | 5.08 | A comparison of two nonsteroidal antiinflammatory drugs (diflunisal versus dipyrone) in the treatment of moderate to severe cancer pain: a randomized crossover study. ( Firat, D; Güllü, IH; Savaş, C; Tekuzman, G; Yalçin, S, 1998) |
| "The efficacy and tolerability of diflunisal (500 mg orally, twice daily) and piroxicam (20 mg orally, once daily) were compared in a 12-week open-label study in 44 patients with active rheumatoid arthritis." | 5.06 | Comparison of diflunisal and piroxicam in the management of patients with rheumatoid arthritis. ( Rice, DM, 1987) |
| "Fifty college athletes with acute sprains and strains from football-related activities were randomly assigned to treatment with either diflunisal or acetaminophen with codeine for seven days." | 5.06 | Comparison of diflunisal and acetaminophen with codeine in the treatment of mild to moderate pain due to strains and sprains. ( Indelicato, PA, 1986) |
| "Two nonsteroidal anti-inflammatory drugs, diflunisal and naproxen, were compared for efficacy in relieving anterior knee pain of mild to moderate severity." | 5.06 | Comparison of diflunisal and naproxen for relief of anterior knee pain. ( Folcik, MA; Fulkerson, JP, 1986) |
| "The efficacy and safety of diflunisal versus placebo in the treatment of pain were compared in a multicenter, double-blind study of 1,037 patients treated for seven days by general practitioners." | 5.05 | Diflunisal versus placebo for treatment of pain in general practice. ( Ageorges, P; Ankri, J; Chastang, JF; Fermanian, J; Lancrenon, S; Puech, A; Simon, P; Soubrie, C, 1982) |
| "A single-blind study was carried out in 52 patients with severe pain after Colles' fracture to assess the analgesic efficacy and tolerability of 500 mg diflunisal twice daily compared with that of 500 mg mefenamic acid given 3-times daily over a period of 5 days." | 5.05 | Single-blind study of diflunisal versus mefenamic acid in the treatment of pain after Colles' fracture. ( Barrington, R, 1980) |
| "A double-blind study of 43 patients undergoing excision of haemorrhoids under spinal anaesthesia was carried out to compare the analgesic effects of diflunisal (DFL, 21 patients) and dextropropoxyphene napsylate (DPN, 22 patients) on post-operative pain." | 5.05 | Comparison of diflunisal and dextropropoxyphene napsylate in the treatment of post-operative pain. ( Jalovaara, P; Kiviniemi, H; Ståhlberg, M, 1985) |
| "Diflunisal, a long acting antiinflammatory analgesic was compared in high (1000 mg daily) and low (750 mg daily) doses with placebo in a randomized, double blind study of 6 weeks' duration in patients with osteoarthritis of the knee." | 5.05 | The efficacy of diflunisal in osteoarthritis of the knee. A Canadian Multicenter Study. ( Davis, P; Lee, P; Prat, A, 1985) |
| "A randomized double-blind study in ambulatory patients with osteoarthritis of hip and/or knee was conducted, comparing the efficacy and safety of diflunisal 500 mg daily with ibuprofen 1200 mg daily, and a period of 8 weeks." | 5.04 | A comparative clinical trial of diflunisal and ibuprofen in the control of pain in osteoarthritis. ( Keet, JG, 1979) |
| "In an open study in patients with tumour-induced pain the analgetic effects of the prostaglandin-inhibiting compound diflunisal and the centrally-acting analgetic tilidine N were compared." | 3.67 | [Comparison of diflunisal and tilidine in tumor pain]. ( Brückle, W; Lydtin, H, 1984) |
| "The analgesic activity of diflunisal was evaluated through the measurement of cutaneous sensory and pain thresholds after electrical stimulation." | 3.67 | Effects of diflunisal on cutaneous sensory and pain thresholds. ( Dragani, L; Giamberardino, MA; Obletter, G; Vecchiet, L, 1988) |
| "Diflunisal was found to be an effective analgesic in mild to moderate pain of acute soft tissue injuries, and caused fewer and more tolerable side effects than did acetaminophen with codeine." | 2.66 | Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine. ( DeForge, B; King, DE; Muncie, HL, 1986) |
| "Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity." | 2.36 | Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| " Thus, the increase in diflunisal analgesic response in arthritis may be attributed to pharmacokinetic perturbations, resulting from alterations in serum protein binding and not to changes in drug pharmacodynamics." | 1.27 | Diflunisal pharmacodynamics in experimental arthritis in rats. ( Kasmerski, L; Walker, JS, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (76.92) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Küçükgüzel, SG | 1 |
| Küçükgüzel, I | 1 |
| Tatar, E | 1 |
| Rollas, S | 1 |
| Sahin, F | 1 |
| Güllüce, M | 1 |
| De Clercq, E | 1 |
| Kabasakal, L | 1 |
| Abd El-Alim, SH | 1 |
| Kassem, AA | 1 |
| Basha, M | 1 |
| Salama, A | 1 |
| Walker, JS | 2 |
| Arroyo, JF | 1 |
| Nguyen, T | 1 |
| Day, RO | 1 |
| Cooper, SA | 1 |
| Amadio, P | 1 |
| Brückle, W | 1 |
| Lydtin, H | 1 |
| Forbes, JA | 1 |
| Beaver, WT | 1 |
| White, EH | 1 |
| White, RW | 1 |
| Neilson, GB | 1 |
| Shackleford, RW | 1 |
| Ankri, J | 1 |
| Ageorges, P | 1 |
| Soubrie, C | 1 |
| Puech, A | 1 |
| Simon, P | 1 |
| Chastang, JF | 1 |
| Lancrenon, S | 1 |
| Fermanian, J | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Pakes, GE | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Azanza Perea, JR | 1 |
| Honorato Pérez, JM | 1 |
| Cuena Boy, R | 1 |
| Barrington, R | 1 |
| Yalçin, S | 1 |
| Güllü, IH | 1 |
| Tekuzman, G | 1 |
| Savaş, C | 1 |
| Firat, D | 1 |
| Kizu, J | 1 |
| Tsuchiya, M | 1 |
| Watanabe, S | 1 |
| Yasuno, N | 1 |
| Arakawa, Y | 1 |
| Saijyo, H | 1 |
| Okuda, O | 1 |
| Keet, JG | 1 |
| Garg, A | 1 |
| Jalovaara, P | 1 |
| Kiviniemi, H | 1 |
| Ståhlberg, M | 1 |
| Muncie, HL | 1 |
| King, DE | 1 |
| DeForge, B | 1 |
| Nyström, E | 1 |
| Gustafsson, I | 1 |
| Quiding, H | 1 |
| Aghababian, RV | 1 |
| Kasmerski, L | 1 |
| Dragani, L | 1 |
| Giamberardino, MA | 1 |
| Obletter, G | 1 |
| Vecchiet, L | 1 |
| Rice, DM | 1 |
| Indelicato, PA | 2 |
| Fulkerson, JP | 1 |
| Folcik, MA | 1 |
| Lee, P | 1 |
| Davis, P | 1 |
| Prat, A | 1 |
2 reviews available for diflunisal and Pain
| Article | Year |
|---|---|
New peripherally-acting oral analgesic agents.
Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials | 1983 |
Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis.
Topics: Diflunisal; Drug Interactions; Humans; Kinetics; Osteoarthritis; Pain; Salicylates; Sprains and Stra | 1980 |
17 trials available for diflunisal and Pain
| Article | Year |
|---|---|
Analgesic efficacy of non-steroidal anti-inflammatory drugs in experimental pain in humans.
Topics: Adult; Analgesia; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curv | 1993 |
New peripherally-acting oral analgesic agents.
Topics: Administration, Oral; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials | 1983 |
Diflunisal. A new oral analgesic with an unusually long duration of action.
Topics: Acetaminophen; Administration, Oral; Clinical Trials as Topic; Codeine; Delayed-Action Preparations; | 1982 |
Diflunisal versus placebo for treatment of pain in general practice.
Topics: Clinical Trials as Topic; Diflunisal; Double-Blind Method; Family Practice; Female; Humans; Male; Mi | 1982 |
Single-blind study of diflunisal versus mefenamic acid in the treatment of pain after Colles' fracture.
Topics: Adult; Aged; Colles' Fracture; Diflunisal; Female; Humans; Male; Mefenamic Acid; Middle Aged; Pain; | 1980 |
A comparison of two nonsteroidal antiinflammatory drugs (diflunisal versus dipyrone) in the treatment of moderate to severe cancer pain: a randomized crossover study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase Inhibitors; | 1998 |
Preparation and clinical application of 2% diflunisal oral ointment for painful lesions of the oral mucosa.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diflunisal; Drug Evaluation; Drug Stability | 2001 |
A comparative clinical trial of diflunisal and ibuprofen in the control of pain in osteoarthritis.
Topics: Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Hip Joint; Humans; Ibuprofen; Kne | 1979 |
Comparison of diflunisal and dextropropoxyphene napsylate in the treatment of post-operative pain.
Topics: Administration, Oral; Adult; Aged; Benzilates; Benzophenones; Dextropropoxyphene; Diflunisal; Dipyro | 1985 |
Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine.
Topics: Acetaminophen; Acute Disease; Adult; Back Pain; Clinical Trials as Topic; Codeine; Diflunisal; Drug | 1986 |
The pain intensity at analgesic intake, and the efficacy of diflunisal in single doses and effervescent acetaminophen in single and repeated doses.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Diflunisal; Female; Humans; Male; Pain; Salicylates; | 1988 |
Comparison of diflunisal and acetaminophen with codeine in the management of grade 2 ankle sprain.
Topics: Acetaminophen; Adult; Ankle Injuries; Codeine; Diflunisal; Drug Combinations; Edema; Female; Humans; | 1986 |
Comparison of diflunisal and piroxicam in the management of patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Female; Humans; Male; Midd | 1987 |
Comparison of diflunisal and acetaminophen with codeine in the treatment of mild to moderate pain due to strains and sprains.
Topics: Acetaminophen; Adolescent; Adult; Athletic Injuries; Clinical Trials as Topic; Codeine; Diflunisal; | 1986 |
Comparison of diflunisal and naproxen for relief of anterior knee pain.
Topics: Adult; Clinical Trials as Topic; Diflunisal; Female; Humans; Knee Joint; Male; Naproxen; Pain; Salic | 1986 |
Efficacy of diflunisal versus acetaminophen with codeine in controlling mild to moderate pain after arthroscopy.
Topics: Acetaminophen; Adolescent; Adult; Arthroscopy; Codeine; Diflunisal; Drug Combinations; Drug Evaluati | 1986 |
The efficacy of diflunisal in osteoarthritis of the knee. A Canadian Multicenter Study.
Topics: Adult; Aged; Clinical Trials as Topic; Diflunisal; Digestive System; Female; Humans; Knee Joint; Mal | 1985 |
8 other studies available for diflunisal and Pain
| Article | Year |
|---|---|
Synthesis of some novel heterocyclic compounds derived from diflunisal hydrazide as potential anti-infective and anti-inflammatory agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Diflunisal; Femal | 2007 |
Comparative study of liposomes, ethosomes and transfersomes as carriers for enhancing the transdermal delivery of diflunisal: In vitro and in vivo evaluation.
Topics: Acetic Acid; Administration, Cutaneous; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; | 2019 |
Peripherally acting analgesics.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Aspirin; Diflunisal; Fenoprofen; Humans; Ibupro | 1984 |
[Comparison of diflunisal and tilidine in tumor pain].
Topics: Aged; Cyclohexanecarboxylic Acids; Diflunisal; Dose-Response Relationship, Drug; Humans; Male; Neopl | 1984 |
[Diflunisal].
Topics: Diflunisal; Drug Interactions; Humans; Pain; Salicylates | 1982 |
Pharmacological agents used in implant dentistry.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Dental Implantation, Endosseous; | 1992 |
Diflunisal pharmacodynamics in experimental arthritis in rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Diflunisal; Dose-Response Relationship, Drug; Injection | 1988 |
Effects of diflunisal on cutaneous sensory and pain thresholds.
Topics: Administration, Oral; Adult; Diflunisal; Female; Humans; Male; Pain; Pain Measurement; Sensory Thres | 1988 |