diclofenac and Spasm studies

Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.

Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.

Research Excerpts

Excerpt	Relevance	Reference
"Pain intensity and muscle spasm, assessed respectively by the patient-reported visual analogue scale and investigator-performed finger-to-floor distance test, were determined prior to the injection as well as 1 and 3 h post-injection in 123 patients (per-protocol population)."	3.30	A randomized controlled trial evaluating the short-term efficacy of a single-administration intramuscular injection with the fixed combination of thiocolchicoside-diclofenac versus diclofenac monotherapy in patients with acute moderate-to-severe low back ( Avramidis, K; Iliopoulos, K; Koufaki, P; Mavragani, C; Tsagkalis, A; Tsilikas, S; Zintzaras, E, 2023)
"Non-steroidal anti-inflammatory drugs (NSAIDs) are an effective and common treatment for chronic pain disorders, but long-term use is associated with risk of potentially life-threatening gastrointestinal adverse events (AEs)."	2.78	Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs. ( Kinoshita, Y; Miwa, H; Sugano, K; Takeuchi, T, 2013)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (25.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	1 (25.00)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
A Long Term Study to Investigate the Efficacy and Safety Study of D961H (Esomeprazole) (20 mg Once Daily) for the Prevention of Gastric and/or Duodenal Ulcers Associated With Daily Nonsteroidal Anti-inflammatory Drug (NSAID) Use[NCT00595517]			Phase 3	395 participants (Actual)	Interventional	2007-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
A randomized controlled trial evaluating the short-term efficacy of a single-administration intramuscular injection with the fixed combination of thiocolchicoside-diclofenac versus diclofenac monotherapy in patients with acute moderate-to-severe low back BMC musculoskeletal disorders, 2023, Jun-10, Volume: 24, Issue:1 Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Inject	2023
Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs. BMC gastroenterology, 2013, Mar-26, Volume: 13 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Esomeprazole; Fema	2013
Relief of spasm with diclofenac. Clinical rheumatology, 1988, Volume: 7, Issue:1 Topics: Clinical Trials as Topic; Diclofenac; Humans; Orphenadrine; Spasm	1988

diclofenac and Spasm

Research Excerpts

Research

Studies (4)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Number of Participants Without Gastric and/or Duodenal Ulcer Throughout the Treatment Period

Number of Participants Without Gastric and/or Duodenal Ulcer up to 12 Weeks After Treatment

Number of Participants Without Gastric and/or Duodenal Ulcer up to 24 Weeks After Treatment

Number of Participants Without Gastric and/or Duodenal Ulcer up to 4 Weeks After Treatment

Trials

Other Studies

Authors	Studies
Iliopoulos, K	1
Koufaki, P	1
Tsilikas, S	1
Avramidis, K	1
Tsagkalis, A	1
Mavragani, C	1
Zintzaras, E	1
Sugano, K	1
Kinoshita, Y	1
Miwa, H	1
Takeuchi, T	1
Kulkarni, SK	1
Patil, CS	1
Jain, NK	1
Singh, A	1
Flygare, U	1
Seuri, M	1
Hurme, J	1
Wuolijoki, E	1