diclofenac has been researched along with Melanoma in 7 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Potentially, non-melanoma skin cancer in humans may be prevented with these agents with few adverse effects." | 5.39 | Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice. ( Burcharth, J; Pommergaard, HC; Raskov, H; Rosenberg, J, 2013) |
| "Melanoma is an aggressive cutaneous cancer, whose incidence is growing in recent years, especially in the younger population." | 5.39 | Markers of mitochondrial dysfunction during the diclofenac-induced apoptosis in melanoma cell lines. ( Albano, F; Arcucci, A; De Vendittis, E; Granato, G; Montagnani, S; Romano, S; Ruocco, MR, 2013) |
| "Epithelial non-melanoma skin cancer (NMSC) like actinic keratosis (AK), Bowen's disease (BD) and basal cell carcinoma (BCC) represent the most common malignancies in the fair skinned population." | 2.46 | Taking treatment decisions in non-melanoma skin cancer--the place for topical photodynamic therapy (PDT). ( Sidoroff, A; Thaler, P, 2010) |
| "Melanoma is characterized by high glucose uptake, partially mediated through elevated pyruvate dehydrogenase kinase (PDK), making PDK a potential treatment target in melanoma." | 1.72 | Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities. ( Bakker, BM; de Jong, S; Evers, B; Jalving, M; Tiersma, JF, 2022) |
| "Potentially, non-melanoma skin cancer in humans may be prevented with these agents with few adverse effects." | 1.39 | Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice. ( Burcharth, J; Pommergaard, HC; Raskov, H; Rosenberg, J, 2013) |
| "Melanoma is an aggressive cutaneous cancer, whose incidence is growing in recent years, especially in the younger population." | 1.39 | Markers of mitochondrial dysfunction during the diclofenac-induced apoptosis in melanoma cell lines. ( Albano, F; Arcucci, A; De Vendittis, E; Granato, G; Montagnani, S; Romano, S; Ruocco, MR, 2013) |
| "Cotreatment with sorafenib and diclofenac interrupts a positive feedback signaling loop involving extracellular signal-regulated kinase, cellular phospholipase A2, and COX." | 1.38 | Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma. ( Axelrod, M; Capaldo, BJ; Gioeli, D; Jensen, K; Mackey, A; Roller, DG; Weber, MJ, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Tiersma, JF | 1 |
| Evers, B | 1 |
| Bakker, BM | 1 |
| Jalving, M | 1 |
| de Jong, S | 1 |
| Brummer, C | 1 |
| Faerber, S | 1 |
| Bruss, C | 1 |
| Blank, C | 1 |
| Lacroix, R | 1 |
| Haferkamp, S | 1 |
| Herr, W | 1 |
| Kreutz, M | 2 |
| Renner, K | 2 |
| Gottfried, E | 1 |
| Lang, SA | 1 |
| Bosserhoff, A | 1 |
| Gronwald, W | 1 |
| Rehli, M | 1 |
| Einhell, S | 1 |
| Gedig, I | 1 |
| Singer, K | 1 |
| Seilbeck, A | 1 |
| Mackensen, A | 1 |
| Grauer, O | 1 |
| Hau, P | 1 |
| Dettmer, K | 1 |
| Andreesen, R | 1 |
| Oefner, PJ | 1 |
| Pommergaard, HC | 1 |
| Burcharth, J | 1 |
| Rosenberg, J | 1 |
| Raskov, H | 1 |
| Sidoroff, A | 1 |
| Thaler, P | 1 |
| Roller, DG | 1 |
| Axelrod, M | 1 |
| Capaldo, BJ | 1 |
| Jensen, K | 1 |
| Mackey, A | 1 |
| Weber, MJ | 1 |
| Gioeli, D | 1 |
| Albano, F | 1 |
| Arcucci, A | 1 |
| Granato, G | 1 |
| Romano, S | 1 |
| Montagnani, S | 1 |
| De Vendittis, E | 1 |
| Ruocco, MR | 1 |
1 review available for diclofenac and Melanoma
| Article | Year |
|---|---|
Taking treatment decisions in non-melanoma skin cancer--the place for topical photodynamic therapy (PDT).
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Dermatology; Diclofenac; Humans; M | 2010 |
6 other studies available for diclofenac and Melanoma
| Article | Year |
|---|---|
Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities.
Topics: Dichloroacetic Acid; Diclofenac; Glucose; Humans; Melanoma; Pyruvate Dehydrogenase Acetyl-Transferri | 2022 |
Metabolic targeting synergizes with MAPK inhibition and delays drug resistance in melanoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; | 2019 |
New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carcinoma; Cell Line, Tumor; | 2013 |
Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Calcitriol; Chemoprevention; D | 2013 |
Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Line, Tumor; | 2012 |
Markers of mitochondrial dysfunction during the diclofenac-induced apoptosis in melanoma cell lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Biomarkers, Tumor; Caspase 9; Cell Line, Tumor; | 2013 |