diclofenac has been researched along with Edema in 228 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to compare the clinical efficacies of naproxen sodium-codeine phosphate in combination, benzydamine hydrochloride, and diclofenac potassium for pain, edema, and trismus after lower third molar extraction." | 9.27 | Comparison of Clinical Efficacies of Preoperatively Initiated Naproxen Sodium-Codeine Phosphate in Combination, Diclofenac Potassium, and Benzydamine Hydrochloride for Pain, Edema, and Trismus After Extraction of Impacted Lower Third Molar: A Randomized D ( Cigerim, L; Eroglu, CN, 2018) |
| "According to these results, diclofenac and paracetamol had the same effect on pain reduction of ankle sprains but more acute ankle edema was present in patients who were treated with diclofenac than in patients who were treated with paracetamol." | 9.15 | Efficacy of paracetamol versus diclofenac for Grade II ankle sprains. ( Lyrtzis, C; Natsis, K; Noussios, G; Papadopoulos, C; Papathanasiou, E, 2011) |
| " This safety study compared the GI tolerability, the blood pressure (BP) profile and the incidence of oedema with lumiracoxib and rofecoxib in the treatment of OA." | 9.13 | A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients. ( Krammer, G; Stricker, K; Yu, S, 2008) |
| "A previously published study comparing the efficacy of comfrey extract to a commercial diclofenac (CAS 78213-16-8) preparation in the treatment of unilateral ankle sprains is critically re-evaluated." | 9.12 | Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions). ( Bulitta, M; D'Anchise, R; Giannetti, B, 2007) |
| "The efficacy and safety of aceclofenac (100 mg bid), a new nonsteroidal anti-inflammatory/anti-rheumatic agent, were compared with those of naproxen (500 mg bid) in a multi-centre, twelve-week, randomized, double-blind, parallel-group clinical trial in outpatients with active osteoarthritis of the knee." | 9.08 | Aceclofenac is a well-tolerated alternative to naproxen in the treatment of osteoarthritis. ( Bowdler, J; Frerick, H; Kornasoff, D; Montull, E, 1997) |
| "The aim of present research was to complex aceclofenac with lysine (LYS) and the developed aceclofenac-LYS cocrystal was encapsulated in lipid bilayers of liposomes by employing dual carrier approach for the treatment of pain-related disorders in rheumatoid arthritis (RA)." | 7.85 | Aceclofenac cocrystal nanoliposomes for rheumatoid arthritis with better dermatokinetic attributes: a preclinical study. ( Garg, NK; Goni, VG; Kapil, N; Katare, OP; Pareek, A; Raza, K; Saini, MK; Sharma, G; Thakur, K, 2017) |
| "In this work a diclofenac acid nanosuspension formulation was produced as a novel approach for the treatment of skin inflammation." | 7.83 | Diclofenac acid nanocrystals as an effective strategy to reduce in vivo skin inflammation by improving dermal drug bioavailability. ( Caddeo, C; Ennas, G; Fadda, AM; Lai, F; Marongiu, F; Pireddu, R; Scano, A; Sinico, C; Valenti, D, 2016) |
| "Soft-tissue edema volumes in all diclofenac-treated groups were significantly lower than those observed in the rhBMP-2 alone." | 7.81 | Effects of Diclofenac Sodium on BMP-induced Inflammation in a Rodent Model. ( Jang, KY; Kim, JR; Lee, KB; Wang, H; Wang, JC; Ye, S; Yim, JH, 2015) |
| " Additionally, anti-inflammatory function of gelsolin (8 mg/mouse) compared with anti-inflammatory drug diclofenac sodium (10 mg/kg)] was confirmed in the carrageenan injection induced paw edema where latter was measured by vernier caliper and fluorescent tomography imaging." | 7.81 | Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice. ( Chopra, BS; Choudhary, V; Garg, R; Gupta, AK; Khatri, N; Parasar, D; Sagar, A, 2015) |
| "The study was aimed to investigate the effect of technologically treated diclofenac (release-active dilutions of diclofenac (RAD of diclofenac)) on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model." | 7.80 | Release-active dilutions of diclofenac enhance anti-inflammatory effect of diclofenac in carrageenan-induced rat paw edema model. ( Demidchenko, YO; Epstein, OI; Gorbunov, EA; Mani, K; Mathur, A; Sakat, SS; Tarasov, SA, 2014) |
| " In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats." | 7.79 | Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. ( Eghdami, K; Erfanparast, A; Farshid, AA; Samadi, F; Tamaddonfard, E, 2013) |
| "The aim of this study was to compare the anti-edema effects of a stable prostacyclin analogue, iloprost, with parenteral and local forms of a non-steroidal anti-inflammatory drug, diclofenac sodium, on traumatic soft tissue edema." | 7.76 | Comparison of anti-edema effects of iloprost and diclofenac sodium on traumatic rat paw edema. ( Doğan, A; Kalender, AM; Kılınçoğlu, V; Sebik, A; Toker, S; Uslu, M, 2010) |
| "Swertiamarin, a secoiridoid isolated from the ethyl acetate extract of Enicostemma axillare, was evaluated for antiedematogenic activity using carrageenan-, formalin-, and histamine-induced paw edema methods in rats." | 7.75 | Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare. ( Badami, S; Vaijanathappa, J, 2009) |
| " We have investigated alterations in the glutathione (GSH) level and the activities of anti-oxidative enzymes (superoxide dismutase, catalase, glutathione s-transferase and glutathione reductase) and myeloperoxidase, as marker of acute inflammation, following oral administration of amiodarone and diclofenac in rats with carrageenan-induced paw edema." | 7.74 | Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema. ( Cadirci, E; Dengiz, GO; Halici, M; Halici, Z; Odabasoglu, F; Suleyman, H, 2007) |
| "Combining allopurinol with either diclofenac or indomethacin produced synergistic inhibitory action on rat's paw edema." | 7.72 | Interaction of allopurinol and non-steroidal anti-inflammatory drugs on the carrageenan-induced rat paw edema. ( Al-Arfaj, AS; Al-Dalaan, AN; Alballa, SR; Mustafa, AA; Tuwaijri, AS, 2003) |
| " Diclofenac significantly reduced the carrageenan-induced edema in rat paw at all the time points studied." | 7.72 | Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide. ( Al-Majed, AA; Al-Shabanah, OA; Khattab, M; Mostafa, AM; Raza, M, 2003) |
| "The anti-inflammatory effect of diclofenac alone or in combination with double strength grapefruit juice was investigated on carrageenan-induced rat's paw oedema." | 7.71 | Grapefruit juice potentiates the anti-inflammatory effects of diclofenac on the carrageenan-induced rat's paw oedema. ( Mahgoub, AA, 2002) |
| "The incidence of lower extremity edema (LEE) AEs was generally similar between rofecoxib 12." | 7.71 | A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. ( Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS, 2002) |
| "This study determines the effects of dexamethasone versus co-administered dexamethasone and diclofenac, on carrageenan-evoked spinal c-Fos expression and peripheral oedema in the freely moving rat." | 7.69 | Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and associated spinal c-Fos expression in the rat. ( Besson, JM; Buritova, J; Chapman, V; Honoré, P, 1996) |
| "The mechanical hyperalgesia was assessed by the Randall Selitto paw pressure test, which determines the paw withdrawal thresholds." | 5.43 | Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation. ( Almeida, FR; Cunha, FV; Lopes, EM; Macedo, EM; Oliveira, FA; Piauilino, CA; Santos, WC; Sousa, BP; Sousa, DP, 2016) |
| " Preliminary pharmacokinetic studies have shown in vivo bioconversion of prodrug to diclofenac." | 5.38 | Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. ( Barbieri, KP; Bosquesi, PL; Campos, ML; Chelucci, RC; Chin, CM; de Castro Souto, PC; Matsubara, MH; Moreira, V; Peccinini, RG; Santos, JL; Teixeira, C, 2012) |
| " Importance of aceclofenac as a new generational NSAID has inspired the development of topical dosage forms." | 5.36 | Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats. ( Dua, K; Pabreja, K; Padi, SS, 2010) |
| "When verapamil was combined with diclofenac, in vitro, the inhibitory effect on PMA or OPZ-induced CL response was synergistic." | 5.28 | Verapamil enhances the inhibitory effect of diclofenac on the chemiluminescence of human polymorphonuclear leukocytes and carrageenan-induced rat's paw oedema. ( al-Tuwaijri, AS; Mustafa, AA, 1992) |
| "Diclofenac pretreatment prevented PGI2 synthesis and significantly reduced fluid extravasation." | 5.28 | Bradykinin-induced oedema formation proceeds from B2 receptor stimulation and is potentiated by concomitantly released prostaglandins. ( Afflerbach, F; Berghöfer, A; Llach Puig Neppl, J; Neppl, H; Neuhof, H, 1991) |
| "The aim of this study was to compare the clinical efficacies of naproxen sodium-codeine phosphate in combination, benzydamine hydrochloride, and diclofenac potassium for pain, edema, and trismus after lower third molar extraction." | 5.27 | Comparison of Clinical Efficacies of Preoperatively Initiated Naproxen Sodium-Codeine Phosphate in Combination, Diclofenac Potassium, and Benzydamine Hydrochloride for Pain, Edema, and Trismus After Extraction of Impacted Lower Third Molar: A Randomized D ( Cigerim, L; Eroglu, CN, 2018) |
| "To evaluate whether a diclofenac epolamine + heparin topical (plaster) is more effective than diclofenac plaster alone in reducing deep somatic hyperalgesia in subjects without spontaneous pain and whether the effect is linked to or independent of the anti-edematous action of heparin." | 5.20 | Effects of topical diclofenac plus heparin (DHEP+H plaster) on somatic pain sensitivity in healthy subjects with a latent algogenic condition of the lower limb. ( Affaitati, G; Costantini, R; Fabrizio, A; Frangione, V; Giamberardino, MA; Lanzarotti, A; Lapenna, D; Lopopolo, M; Tafuri, E, 2015) |
| "According to these results, diclofenac and paracetamol had the same effect on pain reduction of ankle sprains but more acute ankle edema was present in patients who were treated with diclofenac than in patients who were treated with paracetamol." | 5.15 | Efficacy of paracetamol versus diclofenac for Grade II ankle sprains. ( Lyrtzis, C; Natsis, K; Noussios, G; Papadopoulos, C; Papathanasiou, E, 2011) |
| " The efficacy and tolerability of a novel plaster containing both diclofenac epolamine (DHEP) and heparin in the treatment of acute painful ankle sprains with oedema was investigated in a randomized, double-blind, placebo-controlled study." | 5.14 | Effect of a plaster containing DHEP and heparin in acute ankle sprains with oedema: a randomized, double-blind, placebo-controlled, clinical study. ( Coudreuse, JM; de Vathaire, F, 2010) |
| " This safety study compared the GI tolerability, the blood pressure (BP) profile and the incidence of oedema with lumiracoxib and rofecoxib in the treatment of OA." | 5.13 | A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients. ( Krammer, G; Stricker, K; Yu, S, 2008) |
| "The cardiorenal safety database from the Celecoxib Long-term Arthritis Safety Study (CLASS) was analyzed to examine whether supratherapeutic doses of celecoxib are associated with decreased renal function and blood pressure (BP) effects compared with standard doses of diclofenac and ibuprofen in osteoarthritis (OA) and rheumatoid arthritis (RA) patients." | 5.12 | Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen. ( Lefkowith, JL; Verburg, KM; West, CR; Whelton, A, 2006) |
| "The purpose of this study was to evaluate the effect of a single intramuscular dose of prednisolone and the prednisolone-diclofenac combination on postoperative pain, trismus, and edema after the removal of third molars." | 5.12 | The effect of a single dose prednisolone with and without diclofenac on pain, trismus, and swelling after removal of mandibular third molars. ( Buyukkurt, MC; Gungormus, M; Kaya, O, 2006) |
| "A previously published study comparing the efficacy of comfrey extract to a commercial diclofenac (CAS 78213-16-8) preparation in the treatment of unilateral ankle sprains is critically re-evaluated." | 5.12 | Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions). ( Bulitta, M; D'Anchise, R; Giannetti, B, 2007) |
| "The efficacy and safety of aceclofenac (100 mg bid), a new nonsteroidal anti-inflammatory/anti-rheumatic agent, were compared with those of naproxen (500 mg bid) in a multi-centre, twelve-week, randomized, double-blind, parallel-group clinical trial in outpatients with active osteoarthritis of the knee." | 5.08 | Aceclofenac is a well-tolerated alternative to naproxen in the treatment of osteoarthritis. ( Bowdler, J; Frerick, H; Kornasoff, D; Montull, E, 1997) |
| " Anti-inflammatory activity was carried carrageenan-induced paw edema model in which indomethacin was used as standard and analgesic activity was evaluated by eddy's hot plate method using diclofenac as standard drug." | 4.12 | Water Mediated One-Pot, Stepwise Green Synthesis, Anti-Inflammatory and Analgesic Activities of (3-Amino-1-Phenyl-1H-Benzo[f]Chromen-2-yl) (1H-Indol-3-yl) Methanone Catalysed by L-Proline. ( Reddy, BS; Reddy, CVR; Reddy, GG, 2022) |
| " The acetylcholinesterase inhibitor (ACHEI); neostigmine, is known clinically for its analgesic effect in the perioperative phases proving high efficacy; besides possessing anti-inflammatory properties controlling immune cells and cytokine level." | 4.02 | The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation. ( Abdel-Bary, A; El-Tahan, RA; Gowayed, MA, 2021) |
| " The methanolic and aqueous leaves extracts of Croton bonplandianus were exposed to anti-inflammatory activity in the carrageenan induced paw edema against standard diclofenac sodium, followed by the histopathlogical examination." | 4.02 | Anti-inflammatory and histopathological studies of leaves extracts of Croton bonplandianus in Albino rats. ( Abrar, H; Arsalan, A; Bano, R; Fatima, K; Hussain, RA; Islam, M; Jahan, N; Mahmud, S; Yasin, H, 2021) |
| " Compounds that showed promising COX-2 selectivity were further subjected to in vivo anti-inflammatory screening applying formalin induced paw edema (acute model) and cotton-pellet induced granuloma (chronic model) assays using celecoxib and diclofenac sodium as reference drugs." | 3.88 | Design, synthesis and evaluation of some pyrazolo[3,4-d]pyrimidine derivatives bearing thiazolidinone moiety as anti-inflammatory agents. ( Ashour, HM; Fahmy, SM; Khalil, MA; Labouta, IM; Nassra, RA; Tageldin, GN, 2018) |
| " The synthesized compounds were screened for their in vivo anti-inflammatory activity in carrageenan-induced rat hind paw edema model at dose 20mg/kg body weight using diclofenac sodium as a standard drug." | 3.88 | Synthesis and Biological Evaluation of Novel 2-(4-acetyl-3-methyl- 5-(arylamino) thiophen-2-yl)-3-arylquinazolin-4(3H)-one Derivatives as Potential Anti-inflammatory and Antioxidant Agents. ( Chaudhari, PS; Chitlange, SS; Nanda, RK, 2018) |
| " Amongst all the synthesized derivatives, compound 56 showed the significant anti-inflammatory activity in both rat paw edema models with very less ulcerogenic liability in comparison to standard diclofenac, celecoxib, and zileuton." | 3.85 | Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity. ( Bandresh, R; Shrivastava, SK; Srivastava, P; Tripathi, A; Tripathi, PN, 2017) |
| "The aim of present research was to complex aceclofenac with lysine (LYS) and the developed aceclofenac-LYS cocrystal was encapsulated in lipid bilayers of liposomes by employing dual carrier approach for the treatment of pain-related disorders in rheumatoid arthritis (RA)." | 3.85 | Aceclofenac cocrystal nanoliposomes for rheumatoid arthritis with better dermatokinetic attributes: a preclinical study. ( Garg, NK; Goni, VG; Kapil, N; Katare, OP; Pareek, A; Raza, K; Saini, MK; Sharma, G; Thakur, K, 2017) |
| "In this work a diclofenac acid nanosuspension formulation was produced as a novel approach for the treatment of skin inflammation." | 3.83 | Diclofenac acid nanocrystals as an effective strategy to reduce in vivo skin inflammation by improving dermal drug bioavailability. ( Caddeo, C; Ennas, G; Fadda, AM; Lai, F; Marongiu, F; Pireddu, R; Scano, A; Sinico, C; Valenti, D, 2016) |
| " Acetic acid-induced writhing test and carrageenan-induced paw edema model were used for evaluation." | 3.83 | Studies on anti-inflammatory and analgesic properties of Lactobacillus rhamnosus in experimental animal models. ( Amdekar, S; Singh, V, 2016) |
| " All the compounds were found to cause less gastric ulceration than the standard drug diclofenac." | 3.83 | Synthesis and Pharmacological Evaluation of Tetrazolobenzimidazoles as Novel Anti-inflammatory Agents. ( Kale, MA; Kuberkar, SV; Nawale, RB; Peharkar, MR, 2016) |
| "Anti-inflammatory activity of SiE was investigated in rats using ethyl phenylpropiolate (EPP)-induced ear edema, carrageenan- and arachidonic acid (AA)-induced hind paw edema, and cotton pellet-induced granuloma formation models." | 3.81 | Investigation of anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract. ( Chiranthanut, N; Khonsung, P; Kunanusorn, P; Panthong, A; Pingsusaen, P; Rujjanawate, C, 2015) |
| "Cissus gum has been employed as polymer with sodium alginate in the formulation of diclofenac microbeads and the in vivo mucoprotective properties of the polymer in anti-inflammatory therapy assessed in rats with carrageenan-induced paw edema in comparison to diclofenac powder and commercial diclofenac tablet." | 3.81 | Design of cissus-alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy. ( Aina, OO; Lamprecht, A; Odeku, OA; Okunlola, A; Oridupa, OA; Oyagbemi, AA, 2015) |
| "Soft-tissue edema volumes in all diclofenac-treated groups were significantly lower than those observed in the rhBMP-2 alone." | 3.81 | Effects of Diclofenac Sodium on BMP-induced Inflammation in a Rodent Model. ( Jang, KY; Kim, JR; Lee, KB; Wang, H; Wang, JC; Ye, S; Yim, JH, 2015) |
| " Additionally, anti-inflammatory function of gelsolin (8 mg/mouse) compared with anti-inflammatory drug diclofenac sodium (10 mg/kg)] was confirmed in the carrageenan injection induced paw edema where latter was measured by vernier caliper and fluorescent tomography imaging." | 3.81 | Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice. ( Chopra, BS; Choudhary, V; Garg, R; Gupta, AK; Khatri, N; Parasar, D; Sagar, A, 2015) |
| "The study was aimed to investigate the effect of technologically treated diclofenac (release-active dilutions of diclofenac (RAD of diclofenac)) on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model." | 3.80 | Release-active dilutions of diclofenac enhance anti-inflammatory effect of diclofenac in carrageenan-induced rat paw edema model. ( Demidchenko, YO; Epstein, OI; Gorbunov, EA; Mani, K; Mathur, A; Sakat, SS; Tarasov, SA, 2014) |
| "Aceclofenac, a nonsteroidal anti-inflammatory drug, has a propensity to cause gastric ulcers, while zinc ions are known to possess anti-ulcer and anti-inflammatory activities." | 3.80 | Zinc-aceclofenac complex: synthesis, hydrolysis study and antiinflammatory studies. ( Kale, MA; Nawale, RB; Shelke, R, 2014) |
| " In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats." | 3.79 | Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. ( Eghdami, K; Erfanparast, A; Farshid, AA; Samadi, F; Tamaddonfard, E, 2013) |
| "The anti-edematous and anti-allodynic effects of JZL184 were compared to those of PF-3845, an inhibitor of fatty acid amide hydrolase (FAAH), and diclofenac, a non-selective cyclooxygenase inhibitor." | 3.79 | The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model. ( Chen, Y; Cravatt, BF; Ghosh, S; Gujjar, R; Lichtman, AH; Mahadevan, A; Wise, LE, 2013) |
| " Carrageenan induced paw edema model was used for anti-inflammatory and acetic acid induced model used for analgesic activity." | 3.78 | Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum. ( Afzal, M; Afzal, O; Alam, J; Anwar, F; Gupta, G; Gupta, R; Hakeem, KR; Kazmi, I; Pravez, M; Rahman, M, 2012) |
| " Anti-inflammatory activity screening of some synthesized compounds utilizing in vivo acute carrageenan-induced paw edema standard method in rats exhibited that the prepared heterocycles possess considerable pharmacological properties especially, 4a, 4b, 10a, and 10b which reveal remarkable activities relative to diclofenac sodium (reference standard)." | 3.77 | Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides. ( Barsoum, FF, 2011) |
| " dose with respect to standard diclofenac in carrageenan induced rat paw edema model with lessened propensity to cause gastro-intestinal hypermotility and were found to have nil tendencies to generate gastric ulcers." | 3.77 | Aminocarbonyl arylvinylbenzamides as gastric sparing anti-inflammatory agents. ( Agrawal, SS; Khadse, SC; Talele, GS, 2011) |
| "The aim of this study was to compare the anti-edema effects of a stable prostacyclin analogue, iloprost, with parenteral and local forms of a non-steroidal anti-inflammatory drug, diclofenac sodium, on traumatic soft tissue edema." | 3.76 | Comparison of anti-edema effects of iloprost and diclofenac sodium on traumatic rat paw edema. ( Doğan, A; Kalender, AM; Kılınçoğlu, V; Sebik, A; Toker, S; Uslu, M, 2010) |
| " Among the 12 prepared compounds, Compounds 3d, e, i and j exhibited significant anti-inflammatory activity in model of acute inflammation such as carrageenan-induced rat edema paw while compounds 3d and e showed considerable activity in model of chronic inflammation such as adjuvant-induced arthritis and were compared with diclofenac (13." | 3.75 | Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents. ( Aragade, P; Khode, S; Maddi, V; Mamledesai, S; Palkar, M; Ronad, PK; Satyanarayana, D; Thippeswamy, AH, 2009) |
| "Swertiamarin, a secoiridoid isolated from the ethyl acetate extract of Enicostemma axillare, was evaluated for antiedematogenic activity using carrageenan-, formalin-, and histamine-induced paw edema methods in rats." | 3.75 | Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare. ( Badami, S; Vaijanathappa, J, 2009) |
| " We have investigated alterations in the glutathione (GSH) level and the activities of anti-oxidative enzymes (superoxide dismutase, catalase, glutathione s-transferase and glutathione reductase) and myeloperoxidase, as marker of acute inflammation, following oral administration of amiodarone and diclofenac in rats with carrageenan-induced paw edema." | 3.74 | Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema. ( Cadirci, E; Dengiz, GO; Halici, M; Halici, Z; Odabasoglu, F; Suleyman, H, 2007) |
| " Efficacy of lumiracoxib in rat models of hyperalgesia, oedema, pyresis and arthritis was dose-dependent and similar to diclofenac." | 3.73 | Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. ( Berry, C; Dawson, J; Du, Z; Esser, R; Fox, A; Fujimoto, RA; Haston, W; Kimble, EF; Koehler, J; Marshall, PJ; Peppard, J; Quadros, E; Quintavalla, J; Toscano, K; Urban, L; van Duzer, J; Zhang, X; Zhou, S, 2005) |
| "The anti-inflammatory effect of propolis was compared with that of diclofenac, a non-steroidal anti-inflammatory drug, and L-N(G)-nitro arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, using carrageenin-induced mouse paw edema." | 3.73 | Anti-inflammatory effect of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema. ( Endo, Y; Ishikawa, M; Nakagawasai, O; Nakajima, T; Niijima, F; Sato, T; Satoh, S; Shoji, T; Tadano, T; Tan-No, K, 2006) |
| " The antiinflammatory activity of some synthesized compounds was determined by carrageenan-induced rat paw edema technique using diclofenac as reference drug." | 3.72 | Synthesis and antiinflammatory activity of novel indazolones. ( Abouzid, KA; el-Abhar, HS, 2003) |
| " Hydroxyproline content, edema, and mechanical properties were also evaluated at 1, 3, 7, 14, and 28 days post-trauma." | 3.72 | Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration. ( Côté, CH; Frenette, J; Marsolais, D, 2003) |
| "Combining allopurinol with either diclofenac or indomethacin produced synergistic inhibitory action on rat's paw edema." | 3.72 | Interaction of allopurinol and non-steroidal anti-inflammatory drugs on the carrageenan-induced rat paw edema. ( Al-Arfaj, AS; Al-Dalaan, AN; Alballa, SR; Mustafa, AA; Tuwaijri, AS, 2003) |
| " Diclofenac significantly reduced the carrageenan-induced edema in rat paw at all the time points studied." | 3.72 | Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide. ( Al-Majed, AA; Al-Shabanah, OA; Khattab, M; Mostafa, AM; Raza, M, 2003) |
| "The significant inhibitory action of diclofenac formulated in mixed micelles of lecithin with cholate or deoxycholate was observed on the rat hind paw edema induced by carrageenan." | 3.72 | Effect of mixed micelle formulations including terpenes on the transdermal delivery of diclofenac. ( Hendradi, E; Isowa, K; Nagai, T; Obata, Y; Takayama, K, 2003) |
| "5, 5 and 10 mg kg (-1)) was investigated and compared with diclofenac sodium (5 mg kg (-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests." | 3.71 | Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. ( Büyükokuroğlu, ME, 2002) |
| "The present study was designed to assess the anti-inflammatory activity of hyperbaric oxygen treatment by comparing it with that of diclofenac, a nonsteroidal anti-inflammatory drug, and also to investigate whether hyperbaric oxygen treatment enhances the anti-inflammatory effect of diclofenac in carrageenan-induced paw edema which is commonly employed as an acute inflammation model in rats." | 3.71 | Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats. ( Cimşit, M; Eroglu, L; Sümen, G, 2001) |
| "The anti-inflammatory effect of diclofenac alone or in combination with double strength grapefruit juice was investigated on carrageenan-induced rat's paw oedema." | 3.71 | Grapefruit juice potentiates the anti-inflammatory effects of diclofenac on the carrageenan-induced rat's paw oedema. ( Mahgoub, AA, 2002) |
| " The effect of the extracts against acute inflammation was studied by acetic acid increased vascular permeability and xylene-induced ear edema in mice." | 3.71 | Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats. ( Fadishei, M; Hosseinzadeh, H; Mahmoudi, M; Ramezani, M, 2002) |
| "The incidence of lower extremity edema (LEE) AEs was generally similar between rofecoxib 12." | 3.71 | A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. ( Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS, 2002) |
| "This study determines the effects of dexamethasone versus co-administered dexamethasone and diclofenac, on carrageenan-evoked spinal c-Fos expression and peripheral oedema in the freely moving rat." | 3.69 | Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and associated spinal c-Fos expression in the rat. ( Besson, JM; Buritova, J; Chapman, V; Honoré, P, 1996) |
| " Flutrimazole inhibited mouse ear oedema induced by arachidonic acid, tetradecanoylphorbol-acetate and dithranol, with IC50 values of 3." | 3.69 | Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent. ( Forn, J; García-Rafanell, J; Merlos, M; Vericat, ML, 1996) |
| " In adjuvant arthritis, 50 mg of nimesulide, diclofenac or piroxicam were applied daily to injected paws for 14 days." | 3.69 | Anti-inflammatory activity of topical nimesulide gel in various experimental models. ( Awor, L; Gupta, SK; Joshi, S; Prakash, J; Sengupta, S; Velpandian, T, 1996) |
| "Anti-inflammatory activity of baicalein (5,6,7-trioxyflavone-7-O-beta-D-glucuronide) was greater in the chronic inflammation model (rat adjuvant arthritis, ED50 = 120." | 3.68 | Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots. ( Butenko, IG; Galushko, SV; Gladtchenko, SV, 1993) |
| " The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| "Repeat oral dosing of nabumetone for 1 month maintains anti-inflammatory efficacy in a carrageenan model of paw oedema yet does not cause gastrointestinal damage." | 3.68 | Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac. ( Blower, PR; Gentry, C; Melarange, R; O'Connell, C, 1991) |
| "Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a seleno-organic compound with glutathione peroxidase-like activity in vitro, was compared with indomethacin, BW 755C, and levamisole as an inhibitor of carrageenan- and CVF (cobra venom factor)-induced paw oedema in the rat." | 3.68 | Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen. ( Leyck, S; Parnham, MJ, 1990) |
| ") administered arachidonic acid, the PG precursor, produced a statistically insignificant increase in the inflammatory response, though PG synthesis inhibitors, administered by the same route, markedly attenuated the oedema." | 3.67 | Effect of central prostaglandins on carrageenan-induced pedal oedema in rats. ( Bhattacharya, SK; Das, N, 1984) |
| "Sequential potentiation of antiinflammatory activity of dexamethasone was obtained by co-administration of diclofenac-Na (and indomethacin), but not of phenylbutazone and, apparently, of acetylsalicylic acid (ASA) in the carrageenin rat paw edema." | 3.67 | On steroid-saving drug combinations in carrageenin paw edema and adjuvant arthritis. ( Bekemeier, H; Hirschelmann, R, 1986) |
| "Postoperative pain was self-recorded by the patients using a numerical rating scale at 24-hour intervals for a period of 72 hours." | 2.87 | Pre-Emptive Effect of Dexamethasone and Diclofenac Sodium Associated With Codeine on Pain, Swelling, and Trismus After Third Molar Surgery: A Split-Mouth, Randomized, Triple-Blind, Controlled Clinical Trial. ( Bagordakis, E; Dos Santos, CRR; Falci, SGM; Lima, TC; Pinheiro, MLP, 2018) |
| "No difference was noted regarding trismus in any of the groups." | 2.79 | Comparison of the effect of naproxen, etodolac and diclofenac on postoperative sequels following third molar surgery: a randomised, double-blind, crossover study. ( Akbulut, N; Atakan, C; Çölok, G; Üstüner, E, 2014) |
| "A nonsignificant reduction in trismus occurred in both treatment groups compared with the placebo group." | 2.79 | Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial. ( Al-Mashhadani, BA; Majid, OW, 2014) |
| "Postoperative pain was assessed with a visual analogue scale at 4, 6, 12, 24, and 48 h postoperatively (p." | 2.77 | Comparative study of tramadol combined with dexamethasone and diclofenac sodium in third-molar surgery. ( Brandão, JR; da Silva, LC; de Assunção Oliveira, AC; de Santana Santos, T; de Sousa Santos, JA; Menezes Júnior, LR, 2012) |
| "Diclofenac intake was lower in the Viscoseal group from Day 3 to Day 28 with a proven superiority (LB-CI > 0." | 2.72 | Effects of Viscoseal, a synovial fluid substitute, on recovery after arthroscopic partial meniscectomy and joint lavage. ( Mathies, B, 2006) |
| "Changes in facial swelling and trismus were compared on days 2 and 7 postoperatively." | 2.67 | Randomized double-blind comparison of tiaprofenic acid and diclophenac sodium after third molar surgery. ( Becker, PJ; Grotepass, FW; Roelofse, JA; van der Westhuijzen, AJ, 1994) |
| " Local adverse events were minimum for both groups." | 2.67 | Single blind study to evaluate the efficacy and safety of naproxen gel compared with diclophenac emulgel in the treatment of soft tissue injuries. ( Butrón, F; Galicia, A; Martinez-Zurita, F; Zamora, G, 1994) |
| " The study indicates that visual analogue scales may also be useful in assessment of swelling and that Voltaren in a fixed dosage offers a promising alternative against postoperative pain and swelling." | 2.66 | Voltaren as an analgesic after surgical removal of a lower wisdom tooth. ( Henrikson, PA; Thilander, H; Wåhlander, LA, 1985) |
| " But its long-term administration increases the risk of complications of pharmacotherapy." | 1.51 | Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels. ( Beskhmelnitsyna, EA; Kulikov, AL; Peresypkina, AA; Pokrovskii, MV; Varavin, EI, 2019) |
| "Aceclofenac is a popular analgesic, antipyretic, and nonsteroidal anti-inflammatory drug (NSAID) used for prolonged treatment (at least three months) in musculoskeletal disorders." | 1.48 | Aceclofenac-Galactose Conjugate: Design, Synthesis, Characterization, and Pharmacological and Toxicological Evaluations. ( Boatto, G; Burrai, L; Chegaev, K; Cristiano, C; De Caro, C; Gazzano, E; Lazzarato, L; Magliocca, S; Marabello, D; Marini, E; Nieddu, M; Riganti, C; Rimoli, MG; Rolando, B; Russo, R; Sodano, F, 2018) |
| "Diclofenac was used as standard antiinflammatory drug, and amoxicillin was used as standard antimicrobial agent." | 1.43 | Antibacterial and Antiinflammatory Properties of Bovine Colostrum. ( Angolkar, T; Buttar, HS; Kaur, G; Yadav, R, 2016) |
| "The mechanical hyperalgesia was assessed by the Randall Selitto paw pressure test, which determines the paw withdrawal thresholds." | 1.43 | Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation. ( Almeida, FR; Cunha, FV; Lopes, EM; Macedo, EM; Oliveira, FA; Piauilino, CA; Santos, WC; Sousa, BP; Sousa, DP, 2016) |
| "Diclofenac was used as the standard drug." | 1.43 | Antioxidant, Anti-Inflammatory, and Antitumor Activities of Cultured Mycelia and Fruiting Bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes). ( Greeshma, P; Janardhanan, KK; Neethu, MN; Pandey, M; Ravikumar, KS; Zuhara, KF, 2016) |
| "Curcumin has diverse biological activities including antioxidant and anti-inflammatory activity." | 1.42 | Development and evaluation of curcumin-loaded elastic vesicles as an effective topical anti-inflammatory formulation. ( Agrawal, R; Kaur, IP; Sandhu, SK; Sharma, I, 2015) |
| "Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, antinociceptive, and antipyretic activities." | 1.42 | Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice. ( Chiong, HS; Goh, JZ; Hakim, MN; Tang, SN; Yong, YK; Zuraini, A, 2015) |
| "Tricin treatment also inhibited the pro-inflammatory effect of LPS by blocking the TLR4 signaling mediated activation of cytosolic phospholipase A2 (cPLA2), which is confirmed by specific inhibition of COX-2." | 1.42 | Mechanism of anti-inflammatory effect of tricin, a flavonoid isolated from Njavara rice bran in LPS induced hPBMCs and carrageenan induced rats. ( Helen, A; Jayalekshmi, A; Shalini, V, 2015) |
| "Because atherosclerosis is an inflammatory process involving a series of pathological events such as dyslipidemia, oxidative stress, and blood clotting mechanisms, we hereby report the synthesis and evaluation of novel compounds in which antioxidant, anti-inflammatory, and squalene synthase (SQS) inhibitory/hypolipidemic activities are combined in simple molecules through design." | 1.40 | Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity. ( Kourounakis, AP; Matralis, AN, 2014) |
| "A major concern in the treatment of acute pain/inflammation is the potential for drug-drug interactions resulting from P-gp induction by therapeutic agents co-administered with opioids." | 1.40 | P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac. ( Davis, TP; DeMarco, KM; Laracuente, ML; Ronaldson, PT; Sanchez-Covarrubias, L; Slosky, LM; Thompson, BJ; Zhang, Y, 2014) |
| " Preliminary pharmacokinetic studies have shown in vivo bioconversion of prodrug to diclofenac." | 1.38 | Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. ( Barbieri, KP; Bosquesi, PL; Campos, ML; Chelucci, RC; Chin, CM; de Castro Souto, PC; Matsubara, MH; Moreira, V; Peccinini, RG; Santos, JL; Teixeira, C, 2012) |
| "Cryptosporidiosis has been reported in more than 30 avian species worldwide." | 1.36 | Cryptosporidium baileyi infection associated with an outbreak of ocular and respiratory disease in otus owls (Otus scops) in a rehabilitation centre. ( Ares-Mazas, E; Caccio, SM; Darwich, L; Gomez-Couso, H; Leiva, M; Martin-Vazquez, S; Molina-Lopez, RA; Ramis, A, 2010) |
| " Importance of aceclofenac as a new generational NSAID has inspired the development of topical dosage forms." | 1.36 | Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats. ( Dua, K; Pabreja, K; Padi, SS, 2010) |
| "Aceclofenac is a new generation non-steroidal anti-inflammatory drug showing effective anti-inflammatory and analgesic properties." | 1.36 | Aceclofenac topical dosage forms: in vitro and in vivo characterization. ( Dua, K; Pabreja, K; Ramana, MV, 2010) |
| "When there is osteopenia in the radiographs, the condition is called transient osteoporosis." | 1.36 | Migrating bone marrow edema syndrome: a cause of recurring knee pain. ( Suresh, SS, 2010) |
| "The objective of present study was to improve the solubility, dissolution rate, micromeritic properties and bioavailability of aceclofenac (NSAID) by formulating its spherical agglomerates." | 1.34 | Improved bioavailability of aceclofenac from spherical agglomerates: development, in vitro and preclinical studies. ( Muatlik, S; Pandey, S; Ranjith, AK; Reddy, MS; Usha, AN, 2007) |
| "Losartan has an antimigratory effect, reducing leukocyte migration by reducing ICAM-1 and P-selectin expression." | 1.33 | Losartan attenuates the antimigratory effect of diclofenac in spontaneously hypertensive rats. ( Carvalho, MH; Cruz, JW; Fortes, ZB; Martinez, LL; Miguel, AS; Nigro, D; Oliveira, MA; Rastelli, VM; Tostes, RC, 2005) |
| " Owing to sticky and waxy nature of GMO, preparation of oral solid dosage form utilizing GMO is still a challenge for pharmaceutical researchers." | 1.33 | Spray dried glyceryl monooleate-magnesium trisilicate dry powder as cubic phase precursor. ( Biradar, SV; Paradkar, AR; Shah, MH, 2006) |
| "Diclofenac sodium was used as a standard drug." | 1.32 | Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation. ( Jegadeesan, M; Vetrichelvan, T, 2003) |
| " The pharmacodynamic study was carried out to evaluate the effect of Trikatu on the anti-inflammatory activity of diclofenac sodium using carragenin-induced rat paw edema model." | 1.32 | Pharmacokinetic and pharmacodynamic studies on interaction of "Trikatu" with diclofenac sodium. ( D'Mello, PM; Lala, LG; Naik, SR, 2004) |
| "Diclofenac sodium was formulated as novel enteric microcapsules for improved delivery to the intestine using the polymers cellulose acetate phthalate (CAP) and ethyl cellulose (EC)." | 1.32 | Dual coated erodible microcapsules for modified release of diclofenac sodium. ( Biju, SS; Mishra, PR; Rajan, NS; Saisivam, S, 2004) |
| "In the model of adjuvant arthritis VUFB-16066 improves most of disease symptoms including immunopathological disturbances, which indicates possible disease-modifying activity of the drug." | 1.30 | Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid. ( Andĕrova, E; Jandera, A; Kuchar, M; Panajotova, V, 1997) |
| "Nimesulide was administered intramuscularly at increasing doses of 1." | 1.30 | Anti-inflammatory activity and pharmacokinetic profile of a new parenteral formulation of nimesulide. ( Bhardwaj, RK; Gupta, SK; Sengupta, S; Tyagi, P; Velpandian, T, 1999) |
| "When verapamil was combined with diclofenac, in vitro, the inhibitory effect on PMA or OPZ-induced CL response was synergistic." | 1.28 | Verapamil enhances the inhibitory effect of diclofenac on the chemiluminescence of human polymorphonuclear leukocytes and carrageenan-induced rat's paw oedema. ( al-Tuwaijri, AS; Mustafa, AA, 1992) |
| "Diclofenac pretreatment prevented PGI2 synthesis and significantly reduced fluid extravasation." | 1.28 | Bradykinin-induced oedema formation proceeds from B2 receptor stimulation and is potentiated by concomitantly released prostaglandins. ( Afflerbach, F; Berghöfer, A; Llach Puig Neppl, J; Neppl, H; Neuhof, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (4.82) | 18.7374 |
| 1990's | 25 (10.96) | 18.2507 |
| 2000's | 58 (25.44) | 29.6817 |
| 2010's | 115 (50.44) | 24.3611 |
| 2020's | 19 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Boettcher, I | 1 |
| Elger, W | 1 |
| Kirsch, G | 1 |
| Siegmund, F | 1 |
| Wachtel, H | 1 |
| Closse, A | 1 |
| Haefliger, W | 1 |
| Hauser, D | 1 |
| Gubler, HU | 1 |
| Dewald, B | 1 |
| Baggiolini, M | 1 |
| Khanna, IK | 1 |
| Weier, RM | 1 |
| Yu, Y | 1 |
| Xu, XD | 1 |
| Koszyk, FJ | 1 |
| Collins, PW | 1 |
| Koboldt, CM | 1 |
| Veenhuizen, AW | 1 |
| Perkins, WE | 1 |
| Casler, JJ | 1 |
| Masferrer, JL | 1 |
| Zhang, YY | 1 |
| Gregory, SA | 1 |
| Seibert, K | 1 |
| Isakson, PC | 1 |
| Khode, S | 1 |
| Maddi, V | 1 |
| Aragade, P | 1 |
| Palkar, M | 1 |
| Ronad, PK | 1 |
| Mamledesai, S | 1 |
| Thippeswamy, AH | 1 |
| Satyanarayana, D | 1 |
| Sujith, KV | 1 |
| Rao, JN | 1 |
| Shetty, P | 1 |
| Kalluraya, B | 1 |
| Bhandari, SV | 1 |
| Dangre, SC | 1 |
| Bothara, KG | 1 |
| Patil, AA | 1 |
| Sarkate, AP | 1 |
| Lokwani, DK | 1 |
| Gore, ST | 1 |
| Deshmane, BJ | 1 |
| Raparti, VT | 1 |
| Khachane, CV | 1 |
| Mokale, SN | 1 |
| Shinde, SS | 1 |
| Elgire, RD | 1 |
| Sangshetti, JN | 1 |
| Shinde, DB | 1 |
| Abdel-Aziz, AA | 2 |
| ElTahir, KE | 2 |
| Asiri, YA | 2 |
| Rajanarendar, E | 1 |
| Ramakrishna, S | 1 |
| Govardhan Reddy, K | 1 |
| Nagaraju, D | 1 |
| Reddy, YN | 1 |
| Matralis, AN | 1 |
| Kourounakis, AP | 1 |
| Palkar, MB | 1 |
| Singhai, AS | 1 |
| Ronad, PM | 1 |
| Vishwanathswamy, AH | 1 |
| Boreddy, TS | 1 |
| Veerapur, VP | 1 |
| Shaikh, MS | 1 |
| Rane, RA | 1 |
| Karpoormath, R | 1 |
| Alanazi, AM | 1 |
| El-Azab, AS | 1 |
| Al-Suwaidan, IA | 1 |
| Abdel-Aziz, NI | 1 |
| Theodosis-Nobelos, P | 2 |
| Kourti, M | 2 |
| Tziona, P | 1 |
| Kourounakis, PN | 1 |
| Rekka, EA | 2 |
| Gavalas, A | 1 |
| Undare, SS | 1 |
| Valekar, NJ | 1 |
| Patravale, AA | 1 |
| Jamale, DK | 1 |
| Vibhute, SS | 1 |
| Walekar, LS | 1 |
| Kolekar, GB | 1 |
| Deshmukh, MB | 1 |
| Anbhule, PV | 1 |
| Sun, J | 1 |
| Wang, S | 1 |
| Sheng, GH | 1 |
| Lian, ZM | 1 |
| Liu, HY | 1 |
| Zhu, HL | 1 |
| Shchegol'kov, EV | 1 |
| Shchur, IV | 1 |
| Burgart, YV | 1 |
| Saloutin, VI | 1 |
| Trefilova, AN | 1 |
| Ljushina, GA | 1 |
| Solodnikov, SY | 1 |
| Markova, LN | 1 |
| Maslova, VV | 1 |
| Krasnykh, OP | 1 |
| Borisevich, SS | 1 |
| Khursan, SL | 1 |
| Chen, LZ | 1 |
| Sun, WW | 1 |
| Bo, L | 1 |
| Wang, JQ | 1 |
| Xiu, C | 1 |
| Tang, WJ | 1 |
| Shi, JB | 1 |
| Zhou, HP | 1 |
| Liu, XH | 1 |
| Shrivastava, SK | 1 |
| Srivastava, P | 1 |
| Bandresh, R | 1 |
| Tripathi, PN | 1 |
| Tripathi, A | 1 |
| Jan, MS | 1 |
| Ahmad, S | 2 |
| Hussain, F | 1 |
| Ahmad, A | 1 |
| Mahmood, F | 1 |
| Rashid, U | 1 |
| Abid, OU | 1 |
| Ullah, F | 1 |
| Ayaz, M | 1 |
| Sadiq, A | 1 |
| Han, Y | 1 |
| Huang, D | 1 |
| Xu, S | 1 |
| Li, L | 2 |
| Tian, Y | 1 |
| Li, S | 1 |
| Chen, C | 1 |
| Li, Y | 1 |
| Sun, Y | 2 |
| Hou, Y | 1 |
| Qin, M | 1 |
| Gong, P | 1 |
| Gao, Z | 1 |
| Zhao, Y | 1 |
| Chávez-Riveros, A | 1 |
| Hernández-Vázquez, E | 1 |
| Ramírez-Trinidad, Á | 1 |
| Nieto-Camacho, A | 1 |
| Miranda, LD | 1 |
| Sagar, SR | 1 |
| Singh, DP | 1 |
| Das, RD | 1 |
| Panchal, NB | 1 |
| Sudarsanam, V | 1 |
| Nivsarkar, M | 1 |
| Vasu, KK | 1 |
| Kumari, P | 1 |
| Singh, P | 1 |
| Kaur, J | 1 |
| Bhatti, R | 1 |
| Reddy, GG | 1 |
| Reddy, CVR | 1 |
| Reddy, BS | 1 |
| Albarakati, AJA | 1 |
| Nwaehujor, C | 1 |
| Sharma, V | 1 |
| Lal Gupta, G | 1 |
| Sharma, M | 1 |
| Rauf, B | 1 |
| Alyasi, S | 1 |
| Zahra, N | 1 |
| Sarwar, A | 1 |
| Aziz, T | 1 |
| Alharbi, M | 1 |
| Alshammari, A | 1 |
| Alasmari, AF | 1 |
| Karami, Z | 1 |
| Zanjani, MS | 1 |
| Andalib, S | 1 |
| Babaie, H | 1 |
| Aminoroaia, P | 1 |
| Hamdi, BA | 1 |
| Amin, ZA | 1 |
| Shareef, AMY | 1 |
| Al-Bustany, HA | 1 |
| Elmowafy, E | 1 |
| Cespi, M | 1 |
| Bonacucina, G | 1 |
| Soliman, ME | 1 |
| Chaitanya, NC | 1 |
| Badam, R | 1 |
| Siva Prasad Reddy, G | 1 |
| Alwala, A | 1 |
| Srinivas, P | 1 |
| Saawarn, N | 1 |
| Chintada, S | 1 |
| Akhila, M | 1 |
| Bontala, P | 1 |
| Inamdar, P | 1 |
| Mannava, H | 1 |
| Gandhewar, T | 1 |
| Andrade, NN | 1 |
| Aggarwal, N | 1 |
| Choradia, S | 1 |
| Mathai, PC | 1 |
| Nerurkar, S | 1 |
| El-Dash, Y | 1 |
| Khalil, NA | 1 |
| Ahmed, EM | 1 |
| Hassan, MSA | 1 |
| Ragab, FAE | 1 |
| Nissan, YM | 2 |
| Salem, MA | 1 |
| Ali, MM | 1 |
| Selim, AAMA | 1 |
| Pham, TV | 1 |
| Hoang, HNT | 1 |
| Nguyen, HT | 1 |
| Nguyen, HM | 1 |
| Huynh, CT | 1 |
| Vu, TY | 1 |
| Do, AT | 1 |
| Nguyen, NH | 1 |
| Do, BH | 1 |
| Gowayed, MA | 1 |
| Abdel-Bary, A | 1 |
| El-Tahan, RA | 1 |
| Eltom, SEM | 1 |
| Abdellatif, AAH | 1 |
| Maswadeh, H | 1 |
| Al-Omar, MS | 1 |
| Abdel-Hafez, AA | 1 |
| Mohammed, HA | 1 |
| Agabein, EM | 1 |
| Alqasoomi, I | 1 |
| Alrashidi, SA | 1 |
| Sajid, MSM | 1 |
| Mobark, MA | 1 |
| Yasin, H | 1 |
| Mahmud, S | 1 |
| Abrar, H | 1 |
| Arsalan, A | 1 |
| Jahan, N | 1 |
| Fatima, K | 1 |
| Bano, R | 1 |
| Hussain, RA | 1 |
| Islam, M | 1 |
| Lima, CAA | 1 |
| Favarini, VT | 1 |
| Torres, AM | 1 |
| da Silva, RA | 1 |
| Sato, FRL | 1 |
| Lima, TC | 1 |
| Bagordakis, E | 1 |
| Falci, SGM | 1 |
| Dos Santos, CRR | 1 |
| Pinheiro, MLP | 1 |
| Arunkumar, S | 1 |
| Shivakumar, HN | 1 |
| Narasimha Murthy, S | 1 |
| Brignardello-Petersen, R | 1 |
| Cigerim, L | 1 |
| Eroglu, CN | 2 |
| Ahmad, H | 1 |
| Verma, S | 1 |
| Kumar, VL | 3 |
| Prasad, GS | 1 |
| Govardhan, P | 1 |
| Deepika, G | 1 |
| Vakdevi, V | 1 |
| Sashidhar, RB | 1 |
| Quiñones, OG | 1 |
| Hossy, BH | 1 |
| Padua, TA | 1 |
| Miguel, NCO | 1 |
| Rosas, EC | 1 |
| Ramos, MFS | 1 |
| Pierre, MBR | 1 |
| Magliocca, S | 1 |
| De Caro, C | 1 |
| Lazzarato, L | 1 |
| Russo, R | 1 |
| Rolando, B | 1 |
| Chegaev, K | 1 |
| Marini, E | 1 |
| Nieddu, M | 1 |
| Burrai, L | 1 |
| Boatto, G | 1 |
| Cristiano, C | 1 |
| Marabello, D | 1 |
| Gazzano, E | 1 |
| Riganti, C | 1 |
| Sodano, F | 1 |
| Rimoli, MG | 1 |
| Tageldin, GN | 2 |
| Fahmy, SM | 2 |
| Ashour, HM | 2 |
| Khalil, MA | 2 |
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| Mörsdorf, K | 1 |
| Wolf, G | 1 |
| Rainsford, KD | 1 |
| Whitehouse, MW | 1 |
| el-Ghazaly, M | 1 |
| Okpanyi, SN | 1 |
| Arens-Corell, M | 1 |
| al-Tuwaijri, AS | 1 |
| Neppl, H | 1 |
| Neuhof, H | 1 |
| Afflerbach, F | 1 |
| Llach Puig Neppl, J | 1 |
| Berghöfer, A | 1 |
| Wiesenberg-Boettcher, I | 1 |
| Pfeilschifter, J | 1 |
| Schweizer, A | 1 |
| Sallmann, A | 1 |
| Wenk, P | 1 |
| Grau, M | 1 |
| Guasch, J | 1 |
| Montero, JL | 1 |
| Felipe, A | 1 |
| Carrasco, E | 1 |
| Juliá, S | 1 |
| Melarange, R | 1 |
| Gentry, C | 1 |
| O'Connell, C | 1 |
| Blower, PR | 1 |
| Leyck, S | 1 |
| Parnham, MJ | 1 |
| Bekemeier, H | 1 |
| Hirschelmann, R | 1 |
| Symons, AM | 1 |
| Dowling, EJ | 1 |
| Parke, DV | 1 |
| Diebschlag, W | 1 |
| Henrikson, PA | 1 |
| Thilander, H | 1 |
| Wåhlander, LA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 6-Week Multicenter, Randomized, Double-Blind, Double-Dummy, Active-Controlled Parallel Group Clinical Saftey Study to Evaluate Incidence of Predefined Gastrointestinal Adverse Events and Peripheral Edema in Subjects With Primary Osteoarthritis Treated W[NCT00637949] | Phase 3 | 309 participants (Actual) | Interventional | 2000-12-31 | Completed | ||
| Randomized Trial of Mannitol Cream for Pain Relief After a Long Run[NCT01843088] | Phase 1 | 170 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| Early Viscosupplementation After Partial Meniscectomy: a Double Blind, Placebo Controlled Randomized Trial[NCT02629380] | Phase 4 | 90 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diclofenac and Edema
| Article | Year |
|---|---|
[Are there any differences in the cardiovascular tolerance between classical NSAIDs and coxibs?].
Topics: Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseas | 2006 |
The emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Conjunctivitis, | 1996 |
27 trials available for diclofenac and Edema
| Article | Year |
|---|---|
The effects of systemic proteolytic enzyme therapy on pain and swelling in third molar surgery equal to diclofenac therapy: a prospective randomized double blinded clinical trial.
Topics: Diclofenac; Double-Blind Method; Edema; Enzyme Therapy; Humans; Molar, Third; Pain, Postoperative; P | 2020 |
Oral dexamethasone decreases postoperative pain, swelling, and trismus more than diclofenac following third molar removal: a randomized controlled clinical trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Dexamethasone; Diclofenac; Double-Blind Method; Edema; | 2017 |
Pre-Emptive Effect of Dexamethasone and Diclofenac Sodium Associated With Codeine on Pain, Swelling, and Trismus After Third Molar Surgery: A Split-Mouth, Randomized, Triple-Blind, Controlled Clinical Trial.
Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Stero | 2018 |
Comparison of Clinical Efficacies of Preoperatively Initiated Naproxen Sodium-Codeine Phosphate in Combination, Diclofenac Potassium, and Benzydamine Hydrochloride for Pain, Edema, and Trismus After Extraction of Impacted Lower Third Molar: A Randomized D
Topics: Adolescent; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Benzydamine; Codeine | 2018 |
Comparison of the effect of naproxen, etodolac and diclofenac on postoperative sequels following third molar surgery: a randomised, double-blind, crossover study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Double-B | 2014 |
Effects of topical diclofenac plus heparin (DHEP+H plaster) on somatic pain sensitivity in healthy subjects with a latent algogenic condition of the lower limb.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Diclofenac; | 2015 |
Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial.
Topics: Activities of Daily Living; Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents; Anti- | 2014 |
A randomized clinical trial of the effects of submucosal dexamethasone after surgery for mandibular fractures.
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents; Dexamethasone; Diclofenac; Double-Blind Met | 2015 |
Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Edema; | 2016 |
Comparison of the Effects of Daily Single-Dose Use of Flurbiprofen, Diclofenac Sodium, and Tenoxicam on Postoperative Pain, Swelling, and Trismus: A Randomized Double-Blind Study.
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anti-Inflammatory Agents, Non-Steroidal; D | 2016 |
A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients.
Topics: Aged; Arthralgia; Blood Pressure; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationshi | 2008 |
Effect of a plaster containing DHEP and heparin in acute ankle sprains with oedema: a randomized, double-blind, placebo-controlled, clinical study.
Topics: Administration, Topical; Adolescent; Adult; Aged; Ankle Injuries; Anti-Inflammatory Agents, Non-Ster | 2010 |
Diclofenac epolamine plus heparin plaster versus diclofenac epolamine plaster in mild to moderate ankle sprain: a randomized, double-blind, parallel-group, placebo-controlled, multicentre, phase III trial.
Topics: Adolescent; Adult; Aged; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Di | 2011 |
Efficacy of paracetamol versus diclofenac for Grade II ankle sprains.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Ankle Injuries; Anti-Inflammatory Agents | 2011 |
Comparative study of tramadol combined with dexamethasone and diclofenac sodium in third-molar surgery.
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid | 2012 |
Steroidal and non-steroidal cyclooxygenase-2 inhibitor anti-inflammatory drugs as pre-emptive medication in patients undergoing periodontal surgery.
Topics: Adult; Alveolectomy; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Crown Length | 2012 |
Effects of Viscoseal, a synovial fluid substitute, on recovery after arthroscopic partial meniscectomy and joint lavage.
Topics: Activities of Daily Living; Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Arthros | 2006 |
Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen.
Topics: Acid-Base Equilibrium; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, | 2006 |
The effect of a single dose prednisolone with and without diclofenac on pain, trismus, and swelling after removal of mandibular third molars.
Topics: Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agents; Diclofenac; Double-Blind Method; | 2006 |
Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Delayed-Action Preparations; Dic | 2007 |
Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions).
Topics: Acute Disease; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under C | 2007 |
Randomized double-blind comparison of tiaprofenic acid and diclophenac sodium after third molar surgery.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-S | 1994 |
Single blind study to evaluate the efficacy and safety of naproxen gel compared with diclophenac emulgel in the treatment of soft tissue injuries.
Topics: Adult; Contusions; Diclofenac; Edema; Female; Gels; Humans; Male; Middle Aged; Naproxen; Pain Measur | 1994 |
Aceclofenac is a well-tolerated alternative to naproxen in the treatment of osteoarthritis.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Diclof | 1997 |
Double-blind controlled clinical study of the efficacy and tolerability of diclofenac-N-(2-hydroxyethyl)-pyrrolidine lecithin gel compared with diclofenac-N-(2-hydroxyethyl)-pyrrolidine gel in patients with peri and extraarticular inflammatory diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Phar | 1999 |
[Diclofenac in blunt traumatic ankle joint swelling. Volumetric monitoring in a placebo controlled double-blind trial].
Topics: Adolescent; Adult; Ankle Injuries; Athletic Injuries; Clinical Trials as Topic; Contusions; Diclofen | 1986 |
Voltaren as an analgesic after surgical removal of a lower wisdom tooth.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Edema; | 1985 |
199 other studies available for diclofenac and Edema
| Article | Year |
|---|---|
Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Indans; Indenes; M | 1984 |
2,3-Dihydrobenzofuran-2-ones: a new class of highly potent antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Benzofurans; Cattle; Chemical Phenomena; | 1981 |
1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1997 |
Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Female; Male; Mic | 2009 |
Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspergillus; Edema; Esch | 2009 |
Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Edema; Female; Male; Mice; Model | 2009 |
Synthesis and anti-inflammatory activity of some 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Edema; Propionates; Rats; Thiourea | 2010 |
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Crystallography, X-Ray; Cyclooxygenas | 2011 |
A facile synthesis, anti-inflammatory and analgesic activity of isoxazolyl-2,3-dihydrospiro[benzo[f]isoindole-1,3'-indoline]-2',4,9-triones.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dos | 2013 |
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds; | 2014 |
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Computer Simulation; Cyclooxygenase 1 | 2014 |
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2 Inhibito | 2015 |
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine ma | 2015 |
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hype | 2016 |
Synthesis, anti-inflammatory, ulcerogenic and cyclooxygenase activities of indenopyrimidine derivatives.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Binding Sites; Carrageenan; Catalytic Domain; | 2016 |
Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Catalytic Domain; Cyclooxygenase 2; C | 2016 |
Polyfluorinated salicylic acid derivatives as analogs of known drugs: Synthesis, molecular docking and biological evaluation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase Inhib | 2017 |
New arylpyrazoline-coumarins: Synthesis and anti-inflammatory activity.
Topics: Animals; Ankle Joint; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Survival; Cells, Cu | 2017 |
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Cyclooxygenase Inhi | 2017 |
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Carrageenan | 2020 |
Ligand-based optimization to identify novel 2-aminobenzo[d]thiazole derivatives as potent sEH inhibitors with anti-inflammatory effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Carrageenan; Cell Survival; Dose-R | 2021 |
Multicomponent synthesis and preliminary anti-inflammatory activity of lipophilic diphenylamines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Artemia; Cell Survival; Diphenylamine; Disease Mod | 2021 |
Investigations on substituted (2-aminothiazol-5-yl)(imidazo[1,2-a]pyridin-3-yl)methanones for the treatment of Alzheimer's disease.
Topics: Aluminum Chloride; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Respons | 2021 |
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 In | 2021 |
Water Mediated One-Pot, Stepwise Green Synthesis, Anti-Inflammatory and Analgesic Activities of (3-Amino-1-Phenyl-1H-Benzo[f]Chromen-2-yl) (1H-Indol-3-yl) Methanone Catalysed by L-Proline.
Topics: Analgesics; Animals; Anthocyanins; Anti-Inflammatory Agents; Benzopyrans; Carrageenan; Catalysis; Di | 2022 |
Protocatechuic acid counteracts oxidative stress and inflammation in carrageenan-induced paw edema in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Diclofenac; Edema; Hydroxybenzoates; I | 2022 |
Ficus vogelii methanol leaf extract ameliorates inflammation and arthritis by modulating osmotic fragility in C57BL/6J mice.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Diclofenac; Edema; Ficus; G | 2021 |
Oxidative Coupling Assembly Induced Bio-engineered Quercetin Microspheres for the Gastrosparing Delivery of Diclofenac Sodium.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; | 2024 |
Evaluating the influence of Aloe barbadensis extracts on edema induced changes in C-reactive protein and interleukin-6 in albino rats through in vivo and in silico approaches.
Topics: Aloe; Animals; C-Reactive Protein; Diclofenac; Edema; Interleukin-6; Ligands; Molecular Docking Simu | 2023 |
Influence of Poloxamer 188 on Anti-Inflammatory and Analgesic Effects of Diclofenac-Loaded Nanoemulsion: Formulation, Optimization and in Vitro/in Vivo Evaluation.
Topics: Analgesics; Anti-Inflammatory Agents; Diclofenac; Edema; Emulsions; Humans; Pain; Poloxamer; Seizure | 2023 |
Diclofenac sodium and dexamethasone co-therapy restores brain neuron-specific enolase (NSE), S-100 Beta and glial fibrillary acid protein (GFAP) proteins in experimental rat's model: A possible inhibition of P-glycoprotein.
Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; D | 2023 |
Topics: Acrylic Resins; Administration, Buccal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac | 2019 |
ANALGESIC EFFECT OF INTRAVENOUS ASCORBIC ACID VERSUS ACELCOFENAC POST-TRANSALVEOLAR EXTRACTION: A CASE-CONTROL STUDY.
Topics: Administration, Intravenous; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Dic | 2019 |
Synthesis and biological evaluation of new nicotinate derivatives as potential anti-inflammatory agents targeting COX-2 enzyme.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Binding Sites; Catalytic Domain; Cyclooxygenas | 2021 |
Non-ulcerogenic pyrazolyl 2-hydroxychalcones and pyrazolylpyrazolines derived from naturally existing furochromone (khellin): semi-synthesis, docking study and anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenas | 2022 |
Anti-Inflammatory and Antimicrobial Activities of Compounds Isolated from
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Binding Sites; Carrageenan; Coum | 2021 |
The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Dic | 2021 |
The Anti-Inflammatory Effect of a γ-Lactone Isolated from Ostrich Oil of
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Diclofenac; Edema; | 2021 |
Anti-inflammatory and histopathological studies of leaves extracts of Croton bonplandianus in Albino rats.
Topics: Animals; Anti-Inflammatory Agents; Croton; Diclofenac; Disease Models, Animal; Dose-Response Relatio | 2021 |
Effect of terpenes on transdermal iontophoretic delivery of diclofenac potassium under constant voltage.
Topics: Acyclic Monoterpenes; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; C | 2018 |
Dexamethasone seems to reduce pain, swelling, and mouth opening reduction compared with diclofenac after third-molar extraction.
Topics: Dexamethasone; Diclofenac; Edema; Humans; Molar, Third; Pain, Postoperative; Tooth Extraction; Trism | 2017 |
Effect of roxithromycin on mucosal damage, oxidative stress and pro-inflammatory markers in experimental model of colitis.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diclofenac; Edema; | 2018 |
Anti-inflammatory activity of anti-hyperlipidemic drug, fenofibrate, and its phase-I metabolite fenofibric acid: in silico, in vitro, and in vivo studies.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Computer Simulation; Cyclooxygenase 1; Cyclooxygenas | 2018 |
Copaiba oil enhances in vitro/in vivo cutaneous permeability and in vivo anti-inflammatory effect of celecoxib.
Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Diclofenac; Diethylamines; Drug Synergism; Edema; Faba | 2018 |
Aceclofenac-Galactose Conjugate: Design, Synthesis, Characterization, and Pharmacological and Toxicological Evaluations.
Topics: Acute Pain; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Avail | 2018 |
Design, synthesis and evaluation of some pyrazolo[3,4-d]pyrimidine derivatives bearing thiazolidinone moiety as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 I | 2018 |
Synthesis and Biological Evaluation of Novel 2-(4-acetyl-3-methyl- 5-(arylamino) thiophen-2-yl)-3-arylquinazolin-4(3H)-one Derivatives as Potential Anti-inflammatory and Antioxidant Agents.
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Carrageenan; Diclofenac; Disease Models, Anim | 2018 |
In Vivo Evaluation of Anti-inflammatory Activity of 2-[3-Acetyl- 5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-4-methylsulfanylbutyric Acid.
Topics: Animals; Anti-Inflammatory Agents; Butyrates; Carrageenan; Diclofenac; Edema; Foot; Hindlimb; Inflam | 2018 |
Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents; Diclofenac; D | 2019 |
Effect of formulation parameters on pharmacokinetics, pharmacodynamics, and safety of diclofenac nanomedicine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Survival; Diclofenac; Drug Compo | 2019 |
Eutexia for enhanced dissolution rate and anti-inflammatory activity of nonsteroidal anti-inflammatory agents: Caffeine as a melting point modulator.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Carrageenan; Diclofenac; Dru | 2019 |
Synthesis, modeling and biological evaluation of some pyrazolo[3,4-d]pyrimidinones and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidinones as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhi | 2019 |
Effect of IKK-2 inhibitor on local Th1 and Th2 type inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Edema; Female; Hypersensitivity, Delay | 2013 |
Effect of ascophyllan from brown algae Padina tetrastromatica on inflammation and oxidative stress in carrageenan-induced rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Diclofenac; Dinoprostone; Edema; Infla | 2013 |
Microemulsion and poloxamer microemulsion-based gel for sustained transdermal delivery of diclofenac epolamine using in-skin drug depot: in vitro/in vivo evaluation.
Topics: Administration, Cutaneous; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Carra | 2013 |
The anti-inflammatory effect of diclofenac is considerably augmented by topical capsaicinoids-containing patch in carrageenan-induced paw oedema of rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Capsicum; Carrageenan; Diclofenac; Dise | 2013 |
Release-active dilutions of diclofenac enhance anti-inflammatory effect of diclofenac in carrageenan-induced rat paw edema model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Diclofenac | 2014 |
Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carotenoids; Carrageenan; Cyclohexenes; Diclofenac; D | 2013 |
Modifying anti-inflammatory effect of Diclofenac with Murraya koenigii.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Drug Synergism; Drug Therapy, Combinatio | 2014 |
Modulating drug release profiles by lipid semi solid matrix formulations for BCS class II drug--an in vitro and an in vivo study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chemistry, Pharmaceutical; Delayed-Actio | 2015 |
Zinc-aceclofenac complex: synthesis, hydrolysis study and antiinflammatory studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, Pharmaceutical; Computer S | 2014 |
Application of artificial neural networks in prediction of diclofenac sodium release from drug-modified zeolites physical mixtures and antiedematous activity assessment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Carriers; Edema; Male; Mice; Mode | 2014 |
P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B, Mem | 2014 |
Optimization of aceclofenac solid dispersion using Box-Behnken design: in-vitro and in-vivo evaluation.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cellulose; C | 2014 |
Metal ion-induced alginate-locust bean gum IPN microspheres for sustained oral delivery of aceclofenac.
Topics: Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents; Diclofenac; Drug Delivery System | 2015 |
Antiinflammatory properties of the stem-bark of Anopyxis klaineana and its major constituent, methyl angolensate.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Chickens; Diclofenac; Edema; Medicine, African Tradi | 2014 |
Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Costus; Diclofenac; Dinoprostone; Disease Models, An | 2014 |
Development and evaluation of curcumin-loaded elastic vesicles as an effective topical anti-inflammatory formulation.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Biological Availability; Chemistry, Ph | 2015 |
Synthesis, hydrolysis kinetics and pharmacological evaluation of aceclofenac prodrugs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Investigation of anti-inflammatory, antinociceptive and antipyretic activities of Stahlianthus involucratus rhizome ethanol extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Arachidonic Acid; Carragee | 2015 |
Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; | 2015 |
Formulation and Characterization of Aceclofenac -Aloe vera Transemulgel.
Topics: Aloe; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Diclofenac; Disea | 2015 |
[AntI-inflammatory, antipyretic and antimicrobial activity of flavonoid-containing extract of Gratiola officinalis L].
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antipyretics; Diclofenac; Edema; Fever; Fl | 2015 |
Mechanism of anti-inflammatory effect of tricin, a flavonoid isolated from Njavara rice bran in LPS induced hPBMCs and carrageenan induced rats.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan | 2015 |
Design of cissus-alginate microbeads revealing mucoprotection properties in anti-inflammatory therapy.
Topics: Acetates; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Compounds; Carrageena | 2015 |
Effects of Diclofenac Sodium on BMP-induced Inflammation in a Rodent Model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Back; Bone Morphogenetic Protein 2; Cytokines; Dic | 2015 |
Effect of Hautriwaic Acid Isolated from Dodonaea viscosa in a Model of Kaolin/Carrageenan-Induced Monoarthritis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Car | 2015 |
Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, | 2015 |
Antiinflammatory and analgesic effects of Eurycoma longifolia extracts.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cells, Cultured; Cyclooxygenase 2; Diclofena | 2016 |
Antibacterial and Antiinflammatory Properties of Bovine Colostrum.
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Cattle | 2016 |
Diclofenac acid nanocrystals as an effective strategy to reduce in vivo skin inflammation by improving dermal drug bioavailability.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability | 2016 |
Studies on anti-inflammatory and analgesic properties of Lactobacillus rhamnosus in experimental animal models.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Diclofenac; Dise | 2016 |
Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bixaceae; Bromelains; Calcium Chloride; Carrageena | 2016 |
Synthesis and Biological Evaluation of New N-(4-Substituted phenyl)glycine Derivatives as Potential Anti-inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Drug Design; Dru | 2016 |
Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclohexane Monoterpe | 2016 |
Antioxidant, Anti-Inflammatory, and Antitumor Activities of Cultured Mycelia and Fruiting Bodies of the Elm Oyster Mushroom, Hypsizygus ulmarius (Agaricomycetes).
Topics: Agaricales; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Benzothiazoles; | 2016 |
Protective Effect of Metformin against Acute Inflammation and Oxidative Stress in Rat.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Catalase; Diclofenac; Disease Models, | 2016 |
Gelatin-carboxymethyl tamarind gum biocomposites: In vitro characterization & anti-inflammatory pharmacodynamics.
Topics: Animals; Anti-Inflammatory Agents; Calorimetry, Differential Scanning; Diclofenac; Disease Models, A | 2016 |
Synthesis and Pharmacological Evaluation of Tetrazolobenzimidazoles as Novel Anti-inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Benzimidazoles; Carrageenan; Diclofenac; Disease Models, Animal; | 2016 |
Polymer based microspheres of aceclofenac as sustained release parenterals for prolonged anti-inflammatory effect.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Diclofenac; Dr | 2017 |
Aceclofenac cocrystal nanoliposomes for rheumatoid arthritis with better dermatokinetic attributes: a preclinical study.
Topics: Animals; Arthritis, Rheumatoid; Delayed-Action Preparations; Diclofenac; Edema; Humans; Inflammation | 2017 |
Analgesic and anti-inflammatory activities of 80% methanol root extract of Jasminum abyssinicum Hochst. ex. Dc. (Oleaceae) in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-R | 2017 |
Synthesis and pharmacological evaluation of some 3-(2-methylphenyl)-2-substituted amino-quinazolin-4(3H)-ones as analgesic and antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Female; Indicators | 2008 |
Synergistic effect of Kalpaamruthaa on antiarthritic and antiinflammatory properties--its mechanism of action.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Cotton Fiber; Diclofenac; D | 2008 |
Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Edema; Female; Formaldehyde; Free Radica | 2009 |
Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Disease Models, Animal; Edema; F | 2009 |
In vivo transdermal delivery of diclofenac by ion-exchange iontophoresis with geraniol.
Topics: Acyclic Monoterpenes; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; C | 2009 |
Anti-inflammatory and antioxidant effects of Jeevaneeya Rasayana: an ayurvedic polyherbal formulation on acute and chronic models of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonate 5-Lipoxygenase; Arthrit | 2010 |
Case of remitting seronegative symmetrical synovitis with pitting edema (RS3PE syndrome) showing dermatomyositis-like eruption.
Topics: Aged; Antibodies, Antinuclear; Blood Sedimentation; C-Reactive Protein; Dermatomyositis; Diclofenac; | 2010 |
Synthesis and pharmacological characterization of a novel nitric oxide-releasing diclofenac derivative containing a benzofuroxan moiety.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Carrageenan; Cyclooxygenase 2; Diclo | 2010 |
Synthesis, analgesic and anti-inflammatory activities of some novel pyrazolines derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Drug Design; Edema; Hydrazines; Mice; Pai | 2010 |
Cryptosporidium baileyi infection associated with an outbreak of ocular and respiratory disease in otus owls (Otus scops) in a rehabilitation centre.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blepharoptosis; Conjuncti | 2010 |
The antiinflammatory potential of phenolic compounds from Emblica officinalis L. in rat.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Carrageenan; Chromatography, High Pressure Liquid; Di | 2011 |
Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats.
Topics: Acrylic Resins; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrage | 2010 |
Effects of histidine and N-acetylcysteine on diclofenac-induced anti-inflammatory response in acute inflammation in rats.
Topics: Acetylcysteine; Acute Disease; Animals; Carrageenan; Cyclooxygenase Inhibitors; Diclofenac; Drug Syn | 2010 |
Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis.
Topics: Adhesiveness; Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Del | 2010 |
Aceclofenac topical dosage forms: in vitro and in vivo characterization.
Topics: Acrylic Resins; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageen | 2010 |
Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Edema; Female; H | 2011 |
Synthesis, characterization, and biological evaluation of novel diclofenac prodrugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Carrageenan; Crystallography, X | 2011 |
Migrating bone marrow edema syndrome: a cause of recurring knee pain.
Topics: Alendronate; Anti-Inflammatory Agents, Non-Steroidal; Bone Density; Bone Density Conservation Agents | 2010 |
Aminocarbonyl arylvinylbenzamides as gastric sparing anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Carrageenan; Diclofenac; Dose-Response | 2011 |
Protective effect of proteins derived from the latex of Calotropis procera against inflammatory hyperalgesia in monoarthritic rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Calotropis; Carrageenan; Diclofenac; Edema; Female; Fr | 2011 |
Comparison of anti-edema effects of iloprost and diclofenac sodium on traumatic rat paw edema.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Edema; Gels; Iloprost; Infusions, Pare | 2010 |
Anti-inflammatory activities of aqueous/ethanol and methanol extracts of Perna viridis Linn. in mice.
Topics: Animals; Anti-Inflammatory Agents; Bivalvia; Carrageenan; Diclofenac; Edema; Ethanol; Formaldehyde; | 2011 |
Antioxidant and anti-inflammatory effect of polysaccharides from Lobophora variegata on zymosan-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis; Diclofenac; Edema; Hydroxyl Radical; Imm | 2011 |
Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2011 |
Antiinflammatory activities of Hungarian Stachys species and their iridoids.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dos | 2012 |
Phytochemical screening and anti-inflammatory actions of Alangium salviifolium root extract.
Topics: Alangiaceae; Animals; Anti-Inflammatory Agents; Diclofenac; Edema; Plant Extracts; Plant Roots; Rats | 2012 |
Anti-inflammatory effect with high intensity focused ultrasound-mediated pulsatile delivery of diclofenac.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Capsules; Carrageenan; Delayed-Action Preparations; Di | 2012 |
Synthesis and anti-inflammatory activity of some benzofuran and benzopyran-4-one derivatives.
Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Benzopyrans; Binding Sites; Carrageenan; Catalytic D | 2012 |
Topical mannitol reduces inflammatory edema in a rat model of arthritis.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Diclofenac; E | 2012 |
Evaluation of analgesic and anti-inflammatory activity of diospyros cordifolia extract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2011 |
In vitro and in vivo evaluation of drug release from semisolid dosage forms.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, Pharmaceutical | 2011 |
Design, synthesis, computational and biological evaluation of some new hydrazino derivatives of DHA and pyranopyrazoles.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Computational Biology; Cycl | 2012 |
Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Diclofena | 2012 |
Preparation and in vitro in vivo evaluation of aceclofenac loaded alginate microspheres: an investigation of effects of polymer using multiple comparison analysis.
Topics: Adhesiveness; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Chloride; Carrage | 2012 |
The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Carrageenan; Diclo | 2013 |
Novel 3-substituted-1-aryl-5-phenyl-6-anilinopyrazolo[3,4-d]pyrimidin-4-ones: docking, synthesis and pharmacological evaluation as a potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Diclofenac; Dose-Response Relationship, Drug; Edema; M | 2012 |
Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Diclofenac; Dinopro | 2012 |
Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Carrageenan; C | 2013 |
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dantrolene; | 2002 |
Oligoethylene ester derivatives of ketoprofen, naproxen and diclofenac as oral prodrugs: a pharmacological evaluation.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Ester | 2002 |
Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation.
Topics: Achyranthes; Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Dose-Response Relationship, | 2003 |
Role of volatile oil pretreatment and skin cholesterol on permeation of ion-paired diclofenac sodium.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cholesterol | 2000 |
Synthesis and antiinflammatory activity of novel indazolones.
Topics: Animals; Anti-Inflammatory Agents; Diclofenac; Edema; Indazoles; Male; Pyrazoles; Pyridazines; Pyrid | 2003 |
[Synthesis and anti-inflammatory analgesic activities of phenylfuroxan-coupled diclofenac].
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic N-Oxides; Diclofenac; Digestive | 2002 |
Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cyclooxygenase Inhibitors; Diclofenac; | 2003 |
Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration.
Topics: Achilles Tendon; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Edema; Female; Hindli | 2003 |
Interaction of allopurinol and non-steroidal anti-inflammatory drugs on the carrageenan-induced rat paw edema.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dose-Respons | 2003 |
Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Drug Syner | 2003 |
Effect of mixed micelle formulations including terpenes on the transdermal delivery of diclofenac.
Topics: Administration, Cutaneous; Animals; Bile Acids and Salts; Biological Availability; Biological Transp | 2003 |
Pharmacokinetic and pharmacodynamic studies on interaction of "Trikatu" with diclofenac sodium.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Car | 2004 |
Anti-inflammatory and antinociceptive activities of Lippia nodiflora Linn.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; | 2004 |
Effects of different protocol doses of low power gallium-aluminum-arsenate (Ga-Al-As) laser radiation (650 nm) on carrageenan induced rat paw ooedema.
Topics: Adrenalectomy; Aluminum; Animals; Arsenates; Carrageenan; Diclofenac; Edema; Extremities; Gallium; I | 2004 |
Dual coated erodible microcapsules for modified release of diclofenac sodium.
Topics: Animals; Capsules; Delayed-Action Preparations; Diclofenac; Edema; Gastric Mucosa; Male; Rats; Rats, | 2004 |
Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Drug Combinations; Drug Eval | 2004 |
Biopharmaceutical and pharmacodynamic studies on topically applied diclofenac gel available in Indian market.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopharmaceutics; Chemist | 2004 |
Synthesis, biological evaluation and kinetic studies of glyceride prodrugs of diclofenac.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Chromatography, High Pressu | 2004 |
Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Availability; | 2005 |
Parvovirus B19: another agent associated with remitting seronegative symmetrical synovitis with pitting edema.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Viral; Arthritis, Infectious; Diclofenac | 2005 |
Optimization of pulsed electromagnetic field therapy for management of arthritis in rats.
Topics: Acid Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthrit | 2005 |
Losartan attenuates the antimigratory effect of diclofenac in spontaneously hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure; Cell Adhe | 2005 |
Arginine, omega-3 fatty acids and nucleotide-enriched diet augment the anti-inflammatory effect of diclofenac on carrageenan-induced rat paw edema.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Carrageenan; Diclofenac; Diet; Edema; Fa | 2005 |
Anti-inflammatory effect of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Arginine; Carrageenan; Diclofena | 2006 |
Formulation and evaluation of once-a-day transdermal gels of diclofenac diethylamine.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical | 2006 |
Antioxidant and anti-inflammatory activity of extract obtained from Aspergillus candidus MTCC 2202 broth filtrate.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Aspergillus; Biphenyl Compounds; But | 2006 |
Anti-inflammatory, anti-nociceptive and antipyretic effects of extracts of Phrygilanthus acutifolius flowers.
Topics: Acetic Acid; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non- | 2006 |
Spray dried glyceryl monooleate-magnesium trisilicate dry powder as cubic phase precursor.
Topics: Animals; Biological Availability; Carrageenan; Delayed-Action Preparations; Diclofenac; Drug Deliver | 2006 |
Synthesis and pharmacological evaluation of some 3-(4-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema.
Topics: Amiodarone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carrageenan; Catalase; D | 2007 |
Synthesis and pharmacological investigation of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Improved bioavailability of aceclofenac from spherical agglomerates: development, in vitro and preclinical studies.
Topics: Alginates; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Av | 2007 |
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dinoprostone; Disease Mod | 2007 |
Analgesic and antiinflammatory effects of mollic acid glucoside, a 1 alpha-hydroxycycloartenoid saponin extractive from Combretum molle R. Br. ex G. Don (Combretaceae) leaf.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Combretum; Diclofenac; Edema; Female; Hi | 2008 |
Pro-inflammatory effect in mice of CvL, a lectin from the marine sponge Cliona varians.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemotaxis, Leukocyte; Dexamethasone; D | 2008 |
Nanoemulsions as vehicles for transdermal delivery of aceclofenac.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, | 2007 |
Diclofenac attenuates the regional effect of lambda-carrageenan on blood-brain barrier function and cytoarchitecture.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Brain; Carrageenan; Cyclooxyg | 2008 |
Effect of central prostaglandins on carrageenan-induced pedal oedema in rats.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Carrageenan; Diclofenac; Dinoprost; Dinoprost | 1984 |
[Comparative study on the shrinking effect of diclofenac-sodium and an aescin preparation in traumatology].
Topics: Adult; Diclofenac; Edema; Escin; Female; Fractures, Bone; Humans; Male; Middle Aged; Phenylacetates; | 1981 |
Mechanisms involved in the antiinflammatory effect of propolis extract.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Diclofenac; | 1993 |
Acute anti-inflammatory activity and gastrointestinal tolerability of diclofenac and nitrofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Female; Gastrointe | 1993 |
Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Arthritis, | 1993 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |
Comparison of the anti-inflammatory effect and gastrointestinal tolerability of aceclofenac and diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Male; Rats; Rats, | 1996 |
Enhanced effects of co-administered dexamethasone and diclofenac on inflammatory pain processing and associated spinal c-Fos expression in the rat.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dexamethaso | 1996 |
Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent.
Topics: Administration, Topical; Animals; Anthralin; Anti-Inflammatory Agents; Antifungal Agents; Arachidoni | 1996 |
Anti-inflammatory activity of topical nimesulide gel in various experimental models.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1996 |
Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid.
Topics: Abdominal Pain; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Art | 1997 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1998 |
Anti-inflammatory properties of diclofenac transition metalloelement complexes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Edema; Female; In Vitro Techniques; Li | 1998 |
Anti-inflammatory activity and pharmacokinetic profile of a new parenteral formulation of nimesulide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dose-Response Relationshi | 1999 |
Transition metal complexes of diclofenac with potentially interesting anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cobalt; Copper; Crystallography, X-Ra | 2000 |
Hyperbaric oxygen treatment reduces carrageenan-induced acute inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Combined Modality Therapy; Diclofenac | 2001 |
Grapefruit juice potentiates the anti-inflammatory effects of diclofenac on the carrageenan-induced rat's paw oedema.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Citrus; Diclofenac; Drug Synergism; E | 2002 |
BALB/c mice orally pretreated with diclofenac have augmented and accelerated PLNA responses to diclofenac.
Topics: Adjuvants, Immunologic; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dicl | 2002 |
Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Ag | 2002 |
A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Clinical Trials, Phase II as Topic; Clinic | 2002 |
[Anti-edematous, anti-inflammatory and analgesics activity of fentiazac, naproxen and diclofenac sodium].
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Edema; Mice; Naproxen; Perit | 1977 |
[On the efficiency of new antiinflammatory agents. A comparative study (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Benzylidene Compounds; Carrageenan; Diclofenac; Edema; Fenoprofen | 1977 |
Non-steroid anti-inflammatory drugs: combined assay for anti-edemic potency and gastric ulcerogenesis in the same animal.
Topics: Acacia; Adjuvants, Pharmaceutic; Animals; Aspartic Acid; Aspirin; Carrageenan; Diclofenac; Drug Eval | 1977 |
Study of the anti-inflammatory activity of Populus tremula, Solidago virgaurea and Fraxinus excelsior.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Diclofenac; Edema; Male; Pl | 1992 |
Verapamil enhances the inhibitory effect of diclofenac on the chemiluminescence of human polymorphonuclear leukocytes and carrageenan-induced rat's paw oedema.
Topics: Animals; Cell Survival; Diclofenac; Drug Synergism; Edema; Luminescent Measurements; Male; Neutrophi | 1992 |
Bradykinin-induced oedema formation proceeds from B2 receptor stimulation and is potentiated by concomitantly released prostaglandins.
Topics: Animals; Bradykinin; Capillary Permeability; Diclofenac; Edema; Endothelium, Vascular; Epoprostenol; | 1991 |
Pharmacological properties of five diclofenac metabolites identified in human plasma.
Topics: Animals; Arthritis, Experimental; Diclofenac; Dinoprostone; Edema; Humans; In Vitro Techniques; Macr | 1991 |
Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoquinones; Capillary | 1991 |
Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Butanones; Carrageenan; Diclofenac; E | 1991 |
Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non | 1990 |
On steroid-saving drug combinations in carrageenin paw edema and adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Carrageenan; Cyclooxygenase Inhibitors; Dexame | 1986 |
Lipid peroxidation, free radicals and experimental inflammation.
Topics: Animals; Diclofenac; Disease Models, Animal; Edema; Free Radicals; Indomethacin; Inflammation; Lipid | 1988 |