diclofenac has been researched along with Aging in 13 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, the small intestines in old rats of both genders given the 50 mg/kg dosage had >30% fewer ulcers and a fourfold decrease in area of ulceration compared to young rats." | 5.31 | Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy. ( Atchison, CR; Balakumaran, A; Hoffmann, WE; Treinen-Moslen, M; West, AB, 2000) |
| "Diclofenac sodium (DS) may affect the number of Purkinje cells in the developing cerebellum since DS can easily be transported from the maternal to the fetal physiological system during the pregnancy." | 3.76 | Prenatal diclofenac sodium administration increases the number of Purkinje cells in female rats: a stereological study. ( Aslan, H; Cihan, OF; Kaplan, S; Odaci, E; Ragbetli, MC, 2010) |
| "For diclofenac, area under the concentration-time curve over the dosage interval (AUC(tau)) was larger in young subjects (3." | 2.71 | Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib. ( Brenner, SS; Dilger, K; Herrlinger, C; Hofmann, U; Klotz, U; Marx, C; Mürdter, TE, 2003) |
| " In contrast, the small intestines in old rats of both genders given the 50 mg/kg dosage had >30% fewer ulcers and a fourfold decrease in area of ulceration compared to young rats." | 1.31 | Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy. ( Atchison, CR; Balakumaran, A; Hoffmann, WE; Treinen-Moslen, M; West, AB, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Ribeiro, H | 1 |
| Rodrigues, I | 1 |
| Napoleão, L | 1 |
| Lira, L | 1 |
| Marques, D | 1 |
| Veríssimo, M | 1 |
| Andrade, JP | 1 |
| Dourado, M | 1 |
| Madzuki, IN | 1 |
| Lau, SF | 1 |
| Mohamad Shalan, NAA | 1 |
| Mohd Ishak, NI | 1 |
| Mohamed, S | 1 |
| Rocha-Rodrigues, S | 1 |
| Santos-Alves, E | 1 |
| Coxito, PM | 1 |
| Marques-Aleixo, I | 1 |
| Passos, E | 1 |
| Guimarães, JT | 1 |
| Martins, MJ | 1 |
| Oliveira, PJ | 1 |
| Magalhães, J | 1 |
| Ascensão, A | 1 |
| Odaci, E | 1 |
| Cihan, OF | 1 |
| Aslan, H | 1 |
| Ragbetli, MC | 1 |
| Kaplan, S | 1 |
| Dilger, K | 2 |
| Herrlinger, C | 2 |
| Peters, J | 1 |
| Seyberth, HW | 1 |
| Schweer, H | 1 |
| Klotz, U | 2 |
| Brenner, SS | 1 |
| Mürdter, TE | 1 |
| Hofmann, U | 1 |
| Marx, C | 1 |
| Ishihata, A | 2 |
| Sakai, M | 1 |
| Katano, Y | 2 |
| Ogaki, T | 1 |
| Aita, T | 1 |
| Heimpel, H | 1 |
| Heit, W | 1 |
| Graham, MJ | 1 |
| Kent, JE | 1 |
| Molony, V | 1 |
| Atchison, CR | 1 |
| Balakumaran, A | 1 |
| West, AB | 1 |
| Hoffmann, WE | 1 |
| Treinen-Moslen, M | 1 |
| Ngawhirunpat, T | 1 |
| Yoshikawa, H | 1 |
| Hatanaka, T | 1 |
| Koizumi, T | 1 |
| Adachi, I | 1 |
| Peltier, AP | 1 |
| Rivet, JP | 1 |
2 reviews available for diclofenac and Aging
| Article | Year |
|---|---|
Non-steroidal anti-inflammatory drugs (NSAIDs), pain and aging: Adjusting prescription to patient features.
Topics: Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclofenac; Etori | 2022 |
Drug-induced aplastic anaemia: clinical aspects.
Topics: Adolescent; Adult; Aged; Aging; Anemia, Aplastic; Child; Child, Preschool; Chloramphenicol; Colchici | 1980 |
3 trials available for diclofenac and Aging
| Article | Year |
|---|---|
Effects of celecoxib and diclofenac on blood pressure, renal function, and vasoactive prostanoids in young and elderly subjects.
Topics: Adult; Aged; Aging; Biomarkers; Blood Pressure; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 2002 |
Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib.
Topics: Adult; Aged; Aging; Alleles; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Celecoxib; Cross-Over | 2003 |
Effects of four analgesic treatments on the behavioural and cortisol responses of 3-week-old lambs to tail docking.
Topics: Administration, Topical; Aging; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavi | 1997 |
8 other studies available for diclofenac and Aging
| Article | Year |
|---|---|
Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from
Topics: Aging; Animals; Bone Development; Cartilage; Chondrocytes; Diclofenac; Disease Models, Animal; Estro | 2019 |
Combined effects of aging and in vitro non-steroid anti-inflammatory drugs on kidney and liver mitochondrial physiology.
Topics: Age Factors; Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calcium; Diclofenac | 2013 |
Prenatal diclofenac sodium administration increases the number of Purkinje cells in female rats: a stereological study.
Topics: Aging; Animals; Cell Proliferation; Diclofenac; Female; Photogrammetry; Pregnancy; Prenatal Exposure | 2010 |
Vascular contractile effect of urotensin II in young and aged rats: influence of aging and contribution of endothelial nitric oxide.
Topics: Aging; Animals; Aorta, Thoracic; Diclofenac; Endothelium, Vascular; Male; Muscle Contraction; Nitric | 2006 |
Role of prostaglandins in urotensin II-induced vasodilatation in the coronary arteries of aged rats.
Topics: Aging; Analysis of Variance; Animals; Coronary Circulation; Coronary Vessels; Cyclooxygenase Inhibit | 2005 |
Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Diclofenac; Female; | 2000 |
Age-related changes in skin permeability of hydrophilic and lipophilic compounds in rats.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry, Physical; De | 2001 |
[Effect of anti-inflammatory treatment by diclofenac on blood sedimentation especially during arthroses].
Topics: Adolescent; Adult; Aged; Aging; Blood Sedimentation; Diclofenac; Female; Humans; Joint Diseases; Mal | 1978 |