diazepam and Multiple Sclerosis
diazepam has been researched along with Multiple Sclerosis in 30 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"This double-blind cross-over study of 14 severely spastic inpatients with chronic multiple sclerosis reveals that once-daily doses of ketazolam, a new drug, are effective in reducing spasticity in a significant proportion of patients without significant side-effects." | 5.06 | Ketazolam once daily for spasticity: double-blind cross-over study. ( Basmajian, JV; Russell, D; Shankardass, K, 1986) |
"The effects of dantrolene sodium and diazepam were compared in a double crossover study of 42 patients with spasticity due to stable multiple sclerosis." | 5.04 | Comparison of dantrolene sodium and diazepam in the treatment of spasticity. ( Lee, RH; Schmidt, RT; Spehlmann, R, 1976) |
"The effects of diazepam on reflex pathways in patients having complete spinal lesions and in patients having incomplete lesions of the spinal cord or multiple sclerosis are compared to determine whether diazepam has an action at spinal level." | 3.65 | Diazepam effect on reflex activity in patients with complete spinal lesions and in those with other causes of spasticity. ( Ashby, P; MacLeod, S; Verrier, M, 1977) |
" Percentages of improved patients' spasticity scale, mild adverse effect and severe adverse effect were extracted as outcomes." | 2.58 | A mixed treatment comparison on efficacy and safety of treatments for spasticity caused by multiple sclerosis: a systematic review and network meta-analysis. ( Fu, X; Li, J; Li, M; Ma, Q; Wang, C; Wang, Y; Wu, H; Yang, W, 2018) |
"Treatment of spasticity poses a major challenge given the complex clinical presentation and variable efficacy and safety profiles of available drugs." | 2.53 | Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper. ( Comi, G; Gold, R; Hartung, HP; Montalban, X; Otero-Romero, S; Sastre-Garriga, J; Soelberg Sørensen, P; Thompson, AJ; Vermersch, P, 2016) |
Research
Studies (30)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 26 (86.67) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (6.67) | 29.6817 |
2010's | 2 (6.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Fu, X | 1 |
Wang, Y | 1 |
Wang, C | 1 |
Wu, H | 1 |
Li, J | 1 |
Li, M | 1 |
Ma, Q | 1 |
Yang, W | 1 |
Otero-Romero, S | 1 |
Sastre-Garriga, J | 1 |
Comi, G | 1 |
Hartung, HP | 1 |
Soelberg Sørensen, P | 1 |
Thompson, AJ | 1 |
Vermersch, P | 1 |
Gold, R | 1 |
Montalban, X | 1 |
CANAL, N | 1 |
Hung, YY | 1 |
Huang, TL | 1 |
McLeod, JG | 1 |
Dimitrijevic, MR | 1 |
Sherwood, AM | 1 |
Losada de Azpiazu, FJ | 1 |
Sánchez Del Mazo, T | 1 |
Rodríguez Alvarez, E | 1 |
Villar Mirabal, I | 1 |
Fraga García, M | 1 |
Pose Cambeiro, P | 1 |
Schoenberg, HW | 1 |
Gutrich, JM | 1 |
Inobe, J | 1 |
Arakawa, T | 1 |
Mori, T | 1 |
Kumamoto, T | 1 |
Tsuda, T | 1 |
Schmidt, RT | 2 |
Lee, RH | 2 |
Spehlmann, R | 2 |
Verrier, M | 2 |
Ashby, P | 2 |
MacLeod, S | 2 |
From, A | 1 |
Heltberg, A | 1 |
Basmajian, JV | 2 |
Shankardass, K | 1 |
Russell, D | 1 |
Lhermitte, F | 1 |
Roullet, E | 1 |
Lyon-Caen, O | 1 |
Metrot, J | 1 |
Villey, T | 1 |
Bach, MA | 1 |
Tournier-Lasserve, E | 1 |
Chabassol, E | 1 |
Rascol, A | 1 |
Clanet, M | 1 |
Brogden, RN | 1 |
Speight, TM | 1 |
Avery, GS | 1 |
Chyatte, SB | 1 |
Glass, A | 1 |
Hannah, A | 1 |
Kentsmith, DK | 1 |
Carter, TN | 1 |
Ketelaer, P | 1 |
Tyberghein, JM | 1 |
Ketelaer, CJ | 1 |
Cartlidge, NE | 1 |
Hudgson, P | 1 |
Weightman, D | 1 |
Tyler, HR | 1 |
Cendrowski, W | 1 |
Majkowski, J | 1 |
Nathan, PW | 1 |
Höök, O | 1 |
Landin, S | 1 |
Evine, IM | 1 |
Jossmann, PB | 1 |
Friend, DG | 1 |
DeAngelis, V | 1 |
Kane, M | 1 |
Neill, RW | 1 |
Simpson, CA | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
The Effects of EXOPULSE Mollii Suit on Spasticity and Muscular Oxygenation in Patients With Multiple Sclerosis.[NCT05912595] | 36 participants (Anticipated) | Interventional | 2023-05-18 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
5 reviews available for diazepam and Multiple Sclerosis
Article | Year |
---|---|
A mixed treatment comparison on efficacy and safety of treatments for spasticity caused by multiple sclerosis: a systematic review and network meta-analysis.
Topics: Baclofen; Botulinum Toxins, Type A; Cannabinoids; Clonidine; Diazepam; Humans; Multiple Sclerosis; M | 2018 |
Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper.
Topics: Amines; Analgesics; Baclofen; Cannabidiol; Clonidine; Cyclohexanecarboxylic Acids; Dantrolene; Diaze | 2016 |
Spasticity: medical and surgical treatment.
Topics: Ambulatory Care; Ataxia; Baclofen; Dantrolene; Diazepam; Electric Stimulation; Electrodes; Electroen | 1980 |
Baclofen: a preliminary report of its pharmacological properties and therapeutic efficacy in spasticity.
Topics: Adolescent; Adult; Aminobutyrates; Animals; Chlorobenzenes; Chronic Disease; Clinical Trials as Topi | 1974 |
Advances in neurology.
Topics: Analgesics; Anticoagulants; Brain; Brain Neoplasms; Carbamazepine; Cerebrovascular Disorders; Contra | 1968 |
Trials
10 trials available for diazepam and Multiple Sclerosis
Article | Year |
---|---|
Lorazepam and diazepam for relieving catatonic features in multiple sclerosis.
Topics: Adult; Catatonia; Diazepam; Drug Therapy, Combination; Electroshock; Female; Humans; Hypnotics and S | 2007 |
Comparison of dantrolene sodium and diazepam in the treatment of spasticity.
Topics: Clinical Trials as Topic; Dantrolene; Diazepam; Humans; Hydantoins; Multiple Sclerosis; Muscle Spast | 1976 |
A double-blind trial with baclofen (Lioresal) and diazepam in spasticity due to multiple sclerosis.
Topics: Adult; Aged; Aminobutyrates; Chlorobenzenes; Clinical Trials as Topic; Diazepam; Drug Evaluation; Fe | 1975 |
Ketazolam once daily for spasticity: double-blind cross-over study.
Topics: Acute Disease; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clinical Trials as Topic; Di | 1986 |
[Double-blind treatment of 49 cases of chronic multiple sclerosis using hyperbaric oxygen].
Topics: Brain; Clinical Trials as Topic; Diazepam; Double-Blind Method; Evoked Potentials; Humans; Hyperbari | 1986 |
Baclofen: a preliminary report of its pharmacological properties and therapeutic efficacy in spasticity.
Topics: Adolescent; Adult; Aminobutyrates; Animals; Chlorobenzenes; Chronic Disease; Clinical Trials as Topi | 1974 |
Dantrolene sodium: long-term effects in severe spasticity.
Topics: Activities of Daily Living; Adolescent; Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Ce | 1973 |
A comparative trial of dimethothiazine in spastic conditions.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Cerebrovascular Disorders; Clinical Trials as T | 1974 |
A comparison of dantrolene sodium and diazepam in the treatment of spasticity.
Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Dantrolene; Diazepam; | 1974 |
Diazepam in the treatment of spasticity. A preliminary quantitative evaluation.
Topics: Adult; Diazepam; Electrodes; Electromyography; Female; Humans; Male; Middle Aged; Multiple Sclerosis | 1969 |
Other Studies
16 other studies available for diazepam and Multiple Sclerosis
Article | Year |
---|---|
[CLINICAL EXPERIENCES WITH A NEW DRUG OF THE BENZODIAZEPINE SERIES: METHYLDIAZEPINONE].
Topics: Anxiety; Anxiety Disorders; Benzodiazepines; Brain Injuries; Depression; Diazepam; Humans; Mental Di | 1963 |
When drugs can help in multiple sclerosis.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Baclofen; Dantrolene; Diazepam; Humans; Immuno | 1980 |
[Anesthesia in multiple sclerosis patients: a proso of a clinical case].
Topics: Adult; Anesthesia; Diazepam; Epinephrine; Humans; Ketamine; Male; Multiple Sclerosis; Urinary Bladde | 1982 |
Management of vesical dysfunction in multiple sclerosis.
Topics: Bethanechol Compounds; Diazepam; Humans; Multiple Sclerosis; Phenoxybenzamine; Reflex, Abnormal; Uri | 1980 |
[Acquired pendular nystagmus associated with the lesion of tegmentum mesencephali in a patient with probable multiple sclerosis].
Topics: Adult; Brain Diseases; Clonazepam; Diazepam; Female; gamma-Aminobutyric Acid; Humans; Multiple Scler | 2000 |
Diazepam effect on reflex activity in patients with complete spinal lesions and in those with other causes of spasticity.
Topics: Achilles Tendon; Action Potentials; Adult; Diazepam; Female; H-Reflex; Humans; Male; Middle Aged; Mu | 1977 |
The effect of diazepam on presynaptic inhibition in patients with complete and incomplete spinal cord lesions.
Topics: Adult; Diazepam; Electric Stimulation; Female; H-Reflex; Humans; Male; Middle Aged; Multiple Scleros | 1975 |
Treatment of spasticity in multiple sclerosis: comparison of dantrolene sodium and diazepam.
Topics: Dantrolene; Diazepam; Humans; Hydantoins; Multiple Sclerosis; Spasm | 1975 |
Progressive cerebellar dyssynergia. The use of diazepam.
Topics: Adult; Cerebellar Diseases; Diagnosis, Differential; Diazepam; Humans; Male; Middle Aged; Multiple S | 1973 |
[C34.647-Ba (Lioresal) in the treatment of hypertonic manifestations of multiple sclerosis].
Topics: Adult; Aged; Aminobutyrates; Chlorobenzenes; Diazepam; Electromyography; Humans; Middle Aged; Multip | 1973 |
A comparison of baclofen and diazepam in the treatment of spasticity.
Topics: Adult; Aminobutyrates; Body Weight; Chlorine; Diazepam; Female; Humans; Male; Middle Aged; Multiple | 1974 |
Epilepsy in multiple sclerosis.
Topics: Adolescent; Adult; Barbiturates; Basal Ganglia; Carbamazepine; Cerebral Cortex; Demyelinating Diseas | 1972 |
The action of diazepam in neurological disorders with excessive motor activity.
Topics: Brain Diseases; Decerebrate State; Diazepam; Diencephalon; Electromyography; Epilepsy; Hemiplegia; H | 1970 |
[Multiple sclerosis. 7. Rehabilitation].
Topics: Ataxia; Diazepam; Exercise Therapy; Humans; Multiple Sclerosis; Self-Help Devices; Spasm; Urination | 1970 |
Diazepam in the relief of muscle spasm resulting from spinal-cord lesions.
Topics: Adolescent; Adult; Cerebrovascular Disorders; Cervical Vertebrae; Diazepam; Female; Humans; Male; Mi | 1964 |
Use of diazepam for the relief of spasticity in multiple sclerosis.
Topics: Diazepam; Humans; Multiple Sclerosis; Muscles; Spasm | 1964 |