Page last updated: 2024-10-25

diazepam and Multiple Sclerosis

diazepam has been researched along with Multiple Sclerosis in 30 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

Research Excerpts

ExcerptRelevanceReference
"This double-blind cross-over study of 14 severely spastic inpatients with chronic multiple sclerosis reveals that once-daily doses of ketazolam, a new drug, are effective in reducing spasticity in a significant proportion of patients without significant side-effects."5.06Ketazolam once daily for spasticity: double-blind cross-over study. ( Basmajian, JV; Russell, D; Shankardass, K, 1986)
"The effects of dantrolene sodium and diazepam were compared in a double crossover study of 42 patients with spasticity due to stable multiple sclerosis."5.04Comparison of dantrolene sodium and diazepam in the treatment of spasticity. ( Lee, RH; Schmidt, RT; Spehlmann, R, 1976)
"The effects of diazepam on reflex pathways in patients having complete spinal lesions and in patients having incomplete lesions of the spinal cord or multiple sclerosis are compared to determine whether diazepam has an action at spinal level."3.65Diazepam effect on reflex activity in patients with complete spinal lesions and in those with other causes of spasticity. ( Ashby, P; MacLeod, S; Verrier, M, 1977)
" Percentages of improved patients' spasticity scale, mild adverse effect and severe adverse effect were extracted as outcomes."2.58A mixed treatment comparison on efficacy and safety of treatments for spasticity caused by multiple sclerosis: a systematic review and network meta-analysis. ( Fu, X; Li, J; Li, M; Ma, Q; Wang, C; Wang, Y; Wu, H; Yang, W, 2018)
"Treatment of spasticity poses a major challenge given the complex clinical presentation and variable efficacy and safety profiles of available drugs."2.53Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper. ( Comi, G; Gold, R; Hartung, HP; Montalban, X; Otero-Romero, S; Sastre-Garriga, J; Soelberg Sørensen, P; Thompson, AJ; Vermersch, P, 2016)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199026 (86.67)18.7374
1990's0 (0.00)18.2507
2000's2 (6.67)29.6817
2010's2 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fu, X1
Wang, Y1
Wang, C1
Wu, H1
Li, J1
Li, M1
Ma, Q1
Yang, W1
Otero-Romero, S1
Sastre-Garriga, J1
Comi, G1
Hartung, HP1
Soelberg Sørensen, P1
Thompson, AJ1
Vermersch, P1
Gold, R1
Montalban, X1
CANAL, N1
Hung, YY1
Huang, TL1
McLeod, JG1
Dimitrijevic, MR1
Sherwood, AM1
Losada de Azpiazu, FJ1
Sánchez Del Mazo, T1
Rodríguez Alvarez, E1
Villar Mirabal, I1
Fraga García, M1
Pose Cambeiro, P1
Schoenberg, HW1
Gutrich, JM1
Inobe, J1
Arakawa, T1
Mori, T1
Kumamoto, T1
Tsuda, T1
Schmidt, RT2
Lee, RH2
Spehlmann, R2
Verrier, M2
Ashby, P2
MacLeod, S2
From, A1
Heltberg, A1
Basmajian, JV2
Shankardass, K1
Russell, D1
Lhermitte, F1
Roullet, E1
Lyon-Caen, O1
Metrot, J1
Villey, T1
Bach, MA1
Tournier-Lasserve, E1
Chabassol, E1
Rascol, A1
Clanet, M1
Brogden, RN1
Speight, TM1
Avery, GS1
Chyatte, SB1
Glass, A1
Hannah, A1
Kentsmith, DK1
Carter, TN1
Ketelaer, P1
Tyberghein, JM1
Ketelaer, CJ1
Cartlidge, NE1
Hudgson, P1
Weightman, D1
Tyler, HR1
Cendrowski, W1
Majkowski, J1
Nathan, PW1
Höök, O1
Landin, S1
Evine, IM1
Jossmann, PB1
Friend, DG1
DeAngelis, V1
Kane, M1
Neill, RW1
Simpson, CA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of EXOPULSE Mollii Suit on Spasticity and Muscular Oxygenation in Patients With Multiple Sclerosis.[NCT05912595]36 participants (Anticipated)Interventional2023-05-18Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for diazepam and Multiple Sclerosis

ArticleYear
A mixed treatment comparison on efficacy and safety of treatments for spasticity caused by multiple sclerosis: a systematic review and network meta-analysis.
    Clinical rehabilitation, 2018, Volume: 32, Issue:6

    Topics: Baclofen; Botulinum Toxins, Type A; Cannabinoids; Clonidine; Diazepam; Humans; Multiple Sclerosis; M

2018
Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2016, Volume: 22, Issue:11

    Topics: Amines; Analgesics; Baclofen; Cannabidiol; Clonidine; Cyclohexanecarboxylic Acids; Dantrolene; Diaze

2016
Spasticity: medical and surgical treatment.
    Neurology, 1980, Volume: 30, Issue:7 Pt 2

    Topics: Ambulatory Care; Ataxia; Baclofen; Dantrolene; Diazepam; Electric Stimulation; Electrodes; Electroen

1980
Baclofen: a preliminary report of its pharmacological properties and therapeutic efficacy in spasticity.
    Drugs, 1974, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Aminobutyrates; Animals; Chlorobenzenes; Chronic Disease; Clinical Trials as Topi

1974
Advances in neurology.
    The Practitioner, 1968, Volume: 201, Issue:204

    Topics: Analgesics; Anticoagulants; Brain; Brain Neoplasms; Carbamazepine; Cerebrovascular Disorders; Contra

1968

Trials

10 trials available for diazepam and Multiple Sclerosis

ArticleYear
Lorazepam and diazepam for relieving catatonic features in multiple sclerosis.
    Progress in neuro-psychopharmacology & biological psychiatry, 2007, Oct-01, Volume: 31, Issue:7

    Topics: Adult; Catatonia; Diazepam; Drug Therapy, Combination; Electroshock; Female; Humans; Hypnotics and S

2007
Comparison of dantrolene sodium and diazepam in the treatment of spasticity.
    Journal of neurology, neurosurgery, and psychiatry, 1976, Volume: 39, Issue:4

    Topics: Clinical Trials as Topic; Dantrolene; Diazepam; Humans; Hydantoins; Multiple Sclerosis; Muscle Spast

1976
A double-blind trial with baclofen (Lioresal) and diazepam in spasticity due to multiple sclerosis.
    Acta neurologica Scandinavica, 1975, Volume: 51, Issue:2

    Topics: Adult; Aged; Aminobutyrates; Chlorobenzenes; Clinical Trials as Topic; Diazepam; Drug Evaluation; Fe

1975
Ketazolam once daily for spasticity: double-blind cross-over study.
    Archives of physical medicine and rehabilitation, 1986, Volume: 67, Issue:8

    Topics: Acute Disease; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clinical Trials as Topic; Di

1986
[Double-blind treatment of 49 cases of chronic multiple sclerosis using hyperbaric oxygen].
    Revue neurologique, 1986, Volume: 142, Issue:3

    Topics: Brain; Clinical Trials as Topic; Diazepam; Double-Blind Method; Evoked Potentials; Humans; Hyperbari

1986
Baclofen: a preliminary report of its pharmacological properties and therapeutic efficacy in spasticity.
    Drugs, 1974, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Aminobutyrates; Animals; Chlorobenzenes; Chronic Disease; Clinical Trials as Topi

1974
Dantrolene sodium: long-term effects in severe spasticity.
    Archives of physical medicine and rehabilitation, 1973, Volume: 54, Issue:7

    Topics: Activities of Daily Living; Adolescent; Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Ce

1973
A comparative trial of dimethothiazine in spastic conditions.
    The Practitioner, 1974, Volume: 213, Issue:1273

    Topics: Activities of Daily Living; Adolescent; Adult; Aged; Cerebrovascular Disorders; Clinical Trials as T

1974
A comparison of dantrolene sodium and diazepam in the treatment of spasticity.
    Paraplegia, 1974, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Dantrolene; Diazepam;

1974
Diazepam in the treatment of spasticity. A preliminary quantitative evaluation.
    Journal of chronic diseases, 1969, Volume: 22, Issue:1

    Topics: Adult; Diazepam; Electrodes; Electromyography; Female; Humans; Male; Middle Aged; Multiple Sclerosis

1969

Other Studies

16 other studies available for diazepam and Multiple Sclerosis

ArticleYear
[CLINICAL EXPERIENCES WITH A NEW DRUG OF THE BENZODIAZEPINE SERIES: METHYLDIAZEPINONE].
    Minerva medica, 1963, Oct-10, Volume: 54

    Topics: Anxiety; Anxiety Disorders; Benzodiazepines; Brain Injuries; Depression; Diazepam; Humans; Mental Di

1963
When drugs can help in multiple sclerosis.
    Drugs, 1980, Volume: 19, Issue:6

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Baclofen; Dantrolene; Diazepam; Humans; Immuno

1980
[Anesthesia in multiple sclerosis patients: a proso of a clinical case].
    Revista espanola de anestesiologia y reanimacion, 1982, Volume: 29, Issue:5

    Topics: Adult; Anesthesia; Diazepam; Epinephrine; Humans; Ketamine; Male; Multiple Sclerosis; Urinary Bladde

1982
Management of vesical dysfunction in multiple sclerosis.
    Urology, 1980, Volume: 16, Issue:4

    Topics: Bethanechol Compounds; Diazepam; Humans; Multiple Sclerosis; Phenoxybenzamine; Reflex, Abnormal; Uri

1980
[Acquired pendular nystagmus associated with the lesion of tegmentum mesencephali in a patient with probable multiple sclerosis].
    Rinsho shinkeigaku = Clinical neurology, 2000, Volume: 40, Issue:10

    Topics: Adult; Brain Diseases; Clonazepam; Diazepam; Female; gamma-Aminobutyric Acid; Humans; Multiple Scler

2000
Diazepam effect on reflex activity in patients with complete spinal lesions and in those with other causes of spasticity.
    Archives of physical medicine and rehabilitation, 1977, Volume: 58, Issue:4

    Topics: Achilles Tendon; Action Potentials; Adult; Diazepam; Female; H-Reflex; Humans; Male; Middle Aged; Mu

1977
The effect of diazepam on presynaptic inhibition in patients with complete and incomplete spinal cord lesions.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1975, Volume: 2, Issue:3

    Topics: Adult; Diazepam; Electric Stimulation; Female; H-Reflex; Humans; Male; Middle Aged; Multiple Scleros

1975
Treatment of spasticity in multiple sclerosis: comparison of dantrolene sodium and diazepam.
    Transactions of the American Neurological Association, 1975, Volume: 100

    Topics: Dantrolene; Diazepam; Humans; Hydantoins; Multiple Sclerosis; Spasm

1975
Progressive cerebellar dyssynergia. The use of diazepam.
    The Journal of the Kansas Medical Society, 1973, Volume: 74, Issue:4

    Topics: Adult; Cerebellar Diseases; Diagnosis, Differential; Diazepam; Humans; Male; Middle Aged; Multiple S

1973
[C34.647-Ba (Lioresal) in the treatment of hypertonic manifestations of multiple sclerosis].
    Bruxelles medical, 1973, Volume: 53, Issue:11

    Topics: Adult; Aged; Aminobutyrates; Chlorobenzenes; Diazepam; Electromyography; Humans; Middle Aged; Multip

1973
A comparison of baclofen and diazepam in the treatment of spasticity.
    Journal of the neurological sciences, 1974, Volume: 23, Issue:1

    Topics: Adult; Aminobutyrates; Body Weight; Chlorine; Diazepam; Female; Humans; Male; Middle Aged; Multiple

1974
Epilepsy in multiple sclerosis.
    Journal of the neurological sciences, 1972, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Barbiturates; Basal Ganglia; Carbamazepine; Cerebral Cortex; Demyelinating Diseas

1972
The action of diazepam in neurological disorders with excessive motor activity.
    Journal of the neurological sciences, 1970, Volume: 10, Issue:1

    Topics: Brain Diseases; Decerebrate State; Diazepam; Diencephalon; Electromyography; Epilepsy; Hemiplegia; H

1970
[Multiple sclerosis. 7. Rehabilitation].
    Lakartidningen, 1970, Jul-15, Volume: 67, Issue:29

    Topics: Ataxia; Diazepam; Exercise Therapy; Humans; Multiple Sclerosis; Self-Help Devices; Spasm; Urination

1970
Diazepam in the relief of muscle spasm resulting from spinal-cord lesions.
    Annals of physical medicine, 1964, Volume: Suppl

    Topics: Adolescent; Adult; Cerebrovascular Disorders; Cervical Vertebrae; Diazepam; Female; Humans; Male; Mi

1964
Use of diazepam for the relief of spasticity in multiple sclerosis.
    Annals of physical medicine, 1964, Volume: Suppl

    Topics: Diazepam; Humans; Multiple Sclerosis; Muscles; Spasm

1964
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