curcumin and Aneurysm

This study investigated the curcumin effect on the cerebral aneurysm. Apoptosis is known to play a fundamental role in the pathogenesis of a cerebral aneurysm. Therefore, we investigated the effect of curcumin on apoptosis of smooth muscle cells of a cerebral aneurysm-induced male albino rats.. Curcumin reduced altered mitochondrial morphology significantly, evidenced through fluorescence and confocal study. Curcumin treatment reduced the expression of p53, caspase-3, and bax/bxl-2 ratio significantly. Curcumin treatment also reversed the cellular architecture of smooth muscle cell wall significantly. Fluorescence and the confocal study confirmed the reduction in apoptosis in a cerebral aneurysm-induced smooth muscle cells of male albino rats.. Taking all these data together, it may suggest that the curcumin could significantly reduce the CaCl

Topics: Aneurysm; Animals; Apoptosis; Caspase 3; Cerebral Arterial Diseases; Curcumin; Enzyme Inhibitors; Male; Myocytes, Smooth Muscle; Rats