citalopram has been researched along with Ache in 29 studies
Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Escitalopram may have pain-alleviating effects for patients with comorbid pain and depression." | 9.51 | Pain severity and pain interference during major depressive episodes treated with escitalopram and aripiprazole adjunctive therapy: a CAN-BIND-1 report. ( Bhat, V; Diep, C; Frey, BN; Gandhi, W; Kennedy, SH; Khoo, Y; Ladha, KS; Lam, RW; Lou, W; Milev, RV; Ravindran, AV; Rosenek, N; Rotzinger, S; Salomons, T; van Reekum, CM, 2022) |
| " We investigated the antiallodynic and antihyperalgesic effects of intrathecally administered morphine, citalopram, paroxetine, and combinations thereof, in a rat model in which peripheral inflammation was induced by complete Freund's adjuvant (CFA)." | 7.78 | Interaction of morphine and selective serotonin receptor inhibitors in rats experiencing inflammatory pain. ( Jun, IG; Kim, SH; Lee, BS; Park, JY, 2012) |
| " This study compared adherence and persistence rates among MDD patients with comorbid chronic pain-related diseases (CPD, including fibromyalgia, diabetes with neurological manifestations, osteoarthritis, low back pain, and headache) for three antidepressants: duloxetine, venlafaxine XR, and escitalopram." | 7.77 | Treatment adherence and persistence with duloxetine, venlafaxine XR, and escitalopram among patients with major depressive disorder and chronic pain-related diseases. ( Liu, X; Mullins, CD; Wang, J, 2011) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 7.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "Pain is common among opioid-dependent patients, yet pharmacologic strategies are limited." | 6.76 | Escitalopram is associated with reductions in pain severity and pain interference in opioid dependent patients with depressive symptoms. ( Anderson, BJ; Herman, DS; Kettavong, M; Stein, MD; Tsui, JI, 2011) |
| "Escitalopram may have pain-alleviating effects for patients with comorbid pain and depression." | 5.51 | Pain severity and pain interference during major depressive episodes treated with escitalopram and aripiprazole adjunctive therapy: a CAN-BIND-1 report. ( Bhat, V; Diep, C; Frey, BN; Gandhi, W; Kennedy, SH; Khoo, Y; Ladha, KS; Lam, RW; Lou, W; Milev, RV; Ravindran, AV; Rosenek, N; Rotzinger, S; Salomons, T; van Reekum, CM, 2022) |
| "In MDD patients with moderate to severe painful physical symptoms not improving after 4 weeks of treatment with escitalopram, an earlier switch to duloxetine may lead to better pain and functional outcomes." | 5.16 | Early vs. conventional switching of antidepressants in patients with MDD and moderate to severe pain: a double-blind randomized study. ( Abbar, M; Gilaberte, I; Menchón, JM; Neuhauser, D; Papen, R; Pérez, V; Picard, H; Romera, I; Schacht, A, 2012) |
| "Tramadol is widely prescribed for treating acute and chronic forms of pain." | 4.95 | Use of tramadol in psychiatric care: A comprehensive review and report of two cases. ( Gamma, F; Panksepp, J; Rougemont-Bücking, A, 2017) |
| " We investigated the antiallodynic and antihyperalgesic effects of intrathecally administered morphine, citalopram, paroxetine, and combinations thereof, in a rat model in which peripheral inflammation was induced by complete Freund's adjuvant (CFA)." | 3.78 | Interaction of morphine and selective serotonin receptor inhibitors in rats experiencing inflammatory pain. ( Jun, IG; Kim, SH; Lee, BS; Park, JY, 2012) |
| " This study compared adherence and persistence rates among MDD patients with comorbid chronic pain-related diseases (CPD, including fibromyalgia, diabetes with neurological manifestations, osteoarthritis, low back pain, and headache) for three antidepressants: duloxetine, venlafaxine XR, and escitalopram." | 3.77 | Treatment adherence and persistence with duloxetine, venlafaxine XR, and escitalopram among patients with major depressive disorder and chronic pain-related diseases. ( Liu, X; Mullins, CD; Wang, J, 2011) |
| "Out-patients (n=2876) with MDD were treated in the first step of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial with citalopram up to 60 mg/day for up to 14 weeks." | 3.76 | Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D (Sequenced Treatment Alternatives to Relieve Depression) report. ( Cook, IA; Fava, M; Gilmer, WS; Husain, MM; Leuchter, AF; Luther, JF; Rush, AJ; Trivedi, MH; Wisniewski, SR, 2010) |
| " The case presentation illustrates the role of pregabalin in successful medical management of this chronic pain disorder, as well as the management of common psychiatric morbidities associated with this condition." | 3.74 | Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia. ( Jerome, L, 2007) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 3.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "The effect of acute and chronic treatment with three antidepressant drugs on the cortical L-type calcium channel (measured as [3H]nitrendipine binding sites) and on the responsiveness to pain (assessed in the hot-plate test) was tested on the Wistar rat." | 3.68 | Role of calcium channels in effects of antidepressant drugs on responsiveness to pain. ( Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J, 1991) |
| "Pain is common among opioid-dependent patients, yet pharmacologic strategies are limited." | 2.76 | Escitalopram is associated with reductions in pain severity and pain interference in opioid dependent patients with depressive symptoms. ( Anderson, BJ; Herman, DS; Kettavong, M; Stein, MD; Tsui, JI, 2011) |
| "Pain is a significant public health problem, and assessment of pain-related impairment of behavior is a key clinical indicator and treatment target." | 1.51 | Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice. ( Alexander, KS; Miller, LL; Patton, TB; Rodriguez, TR; Sarfo, AN, 2019) |
| "Neuropathic pain is characterized by pain hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to known treatments such as non-steroidal anti-inflammatory drugs or even opioids." | 1.35 | Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief. ( Imai, T; Inoue, K; Nagata, K; Tozaki-Saitoh, H; Tsuda, M; Yamashita, T, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.90) | 18.7374 |
| 1990's | 3 (10.34) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 13 (44.83) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Diep, C | 1 |
| Rosenek, N | 1 |
| Khoo, Y | 1 |
| Gandhi, W | 1 |
| van Reekum, CM | 1 |
| Ravindran, AV | 1 |
| Ladha, KS | 1 |
| Frey, BN | 1 |
| Milev, RV | 1 |
| Rotzinger, S | 1 |
| Lam, RW | 1 |
| Kennedy, SH | 1 |
| Lou, W | 1 |
| Salomons, T | 1 |
| Bhat, V | 1 |
| Jessop, JP | 1 |
| Russell, J | 1 |
| DeJesus, A | 1 |
| Bardolia, C | 1 |
| Hanna, A | 1 |
| Turgeon, J | 1 |
| Michaud, V | 1 |
| Amin, NS | 1 |
| Rougemont-Bücking, A | 1 |
| Gamma, F | 1 |
| Panksepp, J | 1 |
| Jaracz, J | 1 |
| Gattner, K | 1 |
| Jaracz, K | 1 |
| Górna, K | 1 |
| Moczko, J | 1 |
| Hauser, J | 1 |
| Alexander, KS | 1 |
| Rodriguez, TR | 1 |
| Sarfo, AN | 1 |
| Patton, TB | 1 |
| Miller, LL | 1 |
| Pujia, F | 1 |
| Serrao, M | 1 |
| Brienza, M | 1 |
| Vestrini, E | 1 |
| Valente, GO | 1 |
| Coppola, G | 1 |
| Pierelli, F | 1 |
| Hong, J | 1 |
| Novick, D | 1 |
| Montgomery, W | 1 |
| Moneta, MV | 1 |
| Dueñas, H | 1 |
| Peng, X | 1 |
| Haro, JM | 1 |
| John, A | 1 |
| Marchant, AL | 1 |
| Fone, DL | 1 |
| McGregor, JI | 1 |
| Dennis, MS | 1 |
| Tan, JO | 1 |
| Lloyd, K | 1 |
| Nagata, K | 1 |
| Imai, T | 1 |
| Yamashita, T | 1 |
| Tsuda, M | 1 |
| Tozaki-Saitoh, H | 1 |
| Inoue, K | 1 |
| Leuchter, AF | 1 |
| Husain, MM | 2 |
| Cook, IA | 1 |
| Trivedi, MH | 2 |
| Wisniewski, SR | 2 |
| Gilmer, WS | 1 |
| Luther, JF | 2 |
| Fava, M | 2 |
| Rush, AJ | 2 |
| Noehr-Jensen, L | 1 |
| Zwisler, ST | 1 |
| Larsen, F | 1 |
| Sindrup, SH | 1 |
| Damkier, P | 1 |
| Brosen, K | 1 |
| Pettersen, VL | 1 |
| Zapata-Sudo, G | 1 |
| Raimundo, JM | 1 |
| Trachez, MM | 1 |
| Sudo, RT | 1 |
| Kayiran, S | 1 |
| Dursun, E | 1 |
| Dursun, N | 1 |
| Ermutlu, N | 1 |
| Karamürsel, S | 1 |
| Go, AC | 1 |
| Golightly, LK | 1 |
| Barber, GR | 1 |
| Barron, MA | 1 |
| Wang, J | 1 |
| Liu, X | 1 |
| Mullins, CD | 1 |
| Tsui, JI | 1 |
| Herman, DS | 1 |
| Kettavong, M | 1 |
| Anderson, BJ | 1 |
| Stein, MD | 1 |
| Lee, BS | 1 |
| Jun, IG | 1 |
| Kim, SH | 1 |
| Park, JY | 1 |
| Romera, I | 1 |
| Pérez, V | 1 |
| Menchón, JM | 1 |
| Schacht, A | 1 |
| Papen, R | 1 |
| Neuhauser, D | 1 |
| Abbar, M | 1 |
| Picard, H | 1 |
| Gilaberte, I | 1 |
| Mahlberg, R | 1 |
| Kunz, D | 1 |
| Sasse, J | 1 |
| Kirchheiner, J | 1 |
| Bomholt, SF | 1 |
| Mikkelsen, JD | 1 |
| Blackburn-Munro, G | 1 |
| Lenze, EJ | 1 |
| Karp, JF | 1 |
| Mulsant, BH | 1 |
| Blank, S | 1 |
| Shear, MK | 1 |
| Houck, PR | 1 |
| Reynolds, CF | 1 |
| McClintock, SM | 1 |
| Davis, L | 1 |
| Zisook, S | 1 |
| Jerome, L | 1 |
| Baraczka, K | 1 |
| Jankó, Z | 1 |
| Vargha, K | 1 |
| Márkus, H | 1 |
| Karch, AM | 1 |
| Karch, FE | 1 |
| Millan, MJ | 1 |
| Gobert, A | 1 |
| Rivet, JM | 1 |
| Adhumeau-Auclair, A | 1 |
| Cussac, D | 1 |
| Newman-Tancredi, A | 1 |
| Dekeyne, A | 1 |
| Nicolas, JP | 1 |
| Lejeune, F | 1 |
| Antkiewicz-Michaluk, L | 1 |
| Romańska, I | 1 |
| Michaluk, J | 1 |
| Vetulani, J | 1 |
| Testa, R | 1 |
| Angelico, P | 1 |
| Abbiati, GA | 1 |
| Larsen, JJ | 1 |
| Arnt, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sequenced Treatment Alternatives to Relieve Depression[NCT00021528] | Phase 4 | 4,000 participants | Interventional | 2001-07-31 | Completed | ||
| Vortioxetine Monotherapy for Major Depressive Disorder in Type 2 Diabetes: Role of Inflammation, Kynurenine Pathway, and Structural and Functional Brain Connectivity as Biomarkers[NCT03580967] | Phase 4 | 0 participants (Actual) | Interventional | 2019-07-01 | Withdrawn (stopped due to COVID-19 Pandemic interfered with Pt recruitment) | ||
| Antidepressants During Office-Based Buprenorphine[NCT00475878] | Phase 3 | 147 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Depressive symptoms, as measured by self-report during study interviews, using the Beck Depression Inventory II. Scores ranged from 0-63; higher scores indicate more depressive symptoms. (NCT00475878)
Timeframe: 3 months
| Intervention | units on a scale (Mean) |
|---|---|
| 10 mg Escitalopram | 12.31 |
| Placebo | 11.35 |
Drop-out is defined as 7 or more days of missed Buprenorphine doses (NCT00475878)
Timeframe: 3 months
| Intervention | percentage of participants (Number) |
|---|---|
| 10 mg Escitalopram | 33.3 |
| Placebo | 44.0 |
2 reviews available for citalopram and Ache
| Article | Year |
|---|---|
Use of tramadol in psychiatric care: A comprehensive review and report of two cases.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Second-Generation; Citalopram; Depressive Disorder | 2017 |
Somatic symptoms in late-life anxiety: treatment issues.
Topics: Age of Onset; Aged; Anxiety Disorders; Citalopram; Female; Health Status; Humans; Male; Middle Aged; | 2005 |
8 trials available for citalopram and Ache
| Article | Year |
|---|---|
Pain severity and pain interference during major depressive episodes treated with escitalopram and aripiprazole adjunctive therapy: a CAN-BIND-1 report.
Topics: Antidepressive Agents; Aripiprazole; Citalopram; Depressive Disorder, Major; Double-Blind Method; Dr | 2022 |
Effects of a selective serotonin reuptake inhibitor escitalopram on the cutaneous silent period: a randomized controlled study in healthy volunteers.
Topics: Adult; Citalopram; Double-Blind Method; Electric Stimulation; Female; Humans; Isometric Contraction; | 2014 |
Escitalopram is a weak inhibitor of the CYP2D6-catalyzed O-demethylation of (+)-tramadol but does not reduce the hypoalgesic effect in experimental pain.
Topics: Adult; Analgesics, Opioid; Biotransformation; Citalopram; Cross-Over Studies; Cytochrome P-450 CYP2D | 2009 |
Neurofeedback intervention in fibromyalgia syndrome; a randomized, controlled, rater blind clinical trial.
Topics: Adolescent; Adult; Anxiety; Citalopram; Depression; Female; Fibromyalgia; Humans; Middle Aged; Neuro | 2010 |
Escitalopram is associated with reductions in pain severity and pain interference in opioid dependent patients with depressive symptoms.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Second-Generation; Citalopram; Depression; Female; | 2011 |
Early vs. conventional switching of antidepressants in patients with MDD and moderate to severe pain: a double-blind randomized study.
Topics: Activities of Daily Living; Adult; Aged; Antidepressive Agents; Citalopram; Depressive Disorder, Maj | 2012 |
Somatic symptoms in late-life anxiety: treatment issues.
Topics: Age of Onset; Aged; Anxiety Disorders; Citalopram; Female; Health Status; Humans; Male; Middle Aged; | 2005 |
[Clinical experiences with the analgesic effects of citalopram].
Topics: Analgesics; Antidepressive Agents, Second-Generation; Chronic Disease; Citalopram; Fibromyalgia; Hum | 1997 |
20 other studies available for citalopram and Ache
| Article | Year |
|---|---|
Pharmacogenetic Testing in a 70-Year-Old Woman with Polypharmacy and Multiple Comorbidities: A Case Report.
Topics: Aged; Citalopram; Depressive Disorder, Major; Female; Humans; Hydroxymethylglutaryl-CoA Reductase In | 2023 |
Is Venlafaxine More Effective than Escitalopram and Nortriptyline in the Management of Painful Symptoms in Patients with Major Depression?
Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Female; Follow-Up Studies; Hum | 2018 |
Effects of monoamine uptake inhibitors on pain-related depression of nesting in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bupropion; Citalopram; Conditioning, Operant; Dopamin | 2019 |
Real-world outcomes in patients with depression treated with duloxetine or a selective serotonin reuptake inhibitor in East Asia.
Topics: Adult; Asia, Eastern; Citalopram; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Fluo | 2016 |
Recent trends in primary-care antidepressant prescribing to children and young people: an e-cohort study.
Topics: Adolescent; Antidepressive Agents; Anxiety; Child; Citalopram; Cohort Studies; Databases, Factual; D | 2016 |
Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief.
Topics: Action Potentials; Animals; Antidepressive Agents; Cell Line, Tumor; Citalopram; Disease Models, Ani | 2009 |
Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D (Sequenced Treatment Alternatives to Relieve Depression) report.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Citalopram; Cost of Illness; Depression; Drug Admini | 2010 |
Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D (Sequenced Treatment Alternatives to Relieve Depression) report.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Citalopram; Cost of Illness; Depression; Drug Admini | 2010 |
Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D (Sequenced Treatment Alternatives to Relieve Depression) report.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Citalopram; Cost of Illness; Depression; Drug Admini | 2010 |
Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D (Sequenced Treatment Alternatives to Relieve Depression) report.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Citalopram; Cost of Illness; Depression; Drug Admini | 2010 |
The synergistic interaction between morphine and maprotiline after intrathecal injection in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Anima | 2009 |
Linezolid interaction with serotonin reuptake inhibitors: report of two cases and incidence assessment.
Topics: Acetamides; Anti-Infective Agents; Citalopram; Drug Interactions; Female; Humans; Linezolid; Male; M | 2010 |
Treatment adherence and persistence with duloxetine, venlafaxine XR, and escitalopram among patients with major depressive disorder and chronic pain-related diseases.
Topics: Adolescent; Adult; Algorithms; Antidepressive Agents; Chronic Disease; Citalopram; Cyclohexanols; De | 2011 |
Interaction of morphine and selective serotonin receptor inhibitors in rats experiencing inflammatory pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Citalopram; Disease Models, Animal; Hyperalgesia; Inf | 2012 |
Serotonin syndrome with tramadol and citalopram.
Topics: Aged; Citalopram; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Narcotics; Pain; S | 2004 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra | 2005 |
Pain in depression: STAR*D study findings.
Topics: Adolescent; Adult; Aged; Citalopram; Depressive Disorder; Female; Follow-Up Studies; Humans; Male; M | 2007 |
Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia.
Topics: Amitriptyline; Analgesics; Anti-Ulcer Agents; Anticoagulants; Antidepressive Agents; Anxiety; Cardio | 2007 |
What did you say? I can't quite understand your spoken order.
Topics: Antidepressive Agents, Second-Generation; Arthritis; Celecoxib; Citalopram; Cyclooxygenase Inhibitor | 1999 |
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha2-adrenergic and serotonin2C receptors: a comparison with citalopram.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents, Tricyclic; Cerebral Cortex; | 2000 |
Role of calcium channels in effects of antidepressant drugs on responsiveness to pain.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Calcium Channels; Cerebral Cortex | 1991 |
Effect of citalopram, amineptine, imipramine and nortriptyline on stress-induced (footshock) analgesia in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Dibenzocycloheptenes; | 1987 |
Reduction in locomotor activity of arthritic rats as parameter for chronic pain: effect of morphine, acetylsalicylic acid and citalopram.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Chronic Disease; Citalopram; Exploratory Behav | 1985 |