cimetidine and Ulcer
cimetidine has been researched along with Ulcer in 20 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty patients took part in a controlled double blind study comparing the efficacy of colloidal bismuth and cimetidine (800 mg at night) with cimetidine alone in the treatment of ulcerative reflux oesophagitis." | 9.06 | Treatment of ulcerative reflux oesophagitis with colloidal bismuth subcitrate in combination with cimetidine. ( Beker, JA; Borkent, MV, 1988) |
| "The effect of various gastric cytoprotective drugs was studied on the development of indomethacin induced intestinal ulcers." | 7.67 | The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats. ( Beró, T; Jávor, T; Mózsik, G; Németh, A, 1984) |
| "Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats." | 7.67 | Naloxone is protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Ligumsky, M; Marcus, H; Nitzan, M; Rosenbach, Y; Waisman, Y; Zahavi, I, 1985) |
| "The effect of cimetidine (400 mg twice a day) on the short-term healing of chronic peptic ulcer is reported." | 7.66 | Twice-a-day dosage of cimetidine in the short-term treatment of peptic ulcer. ( Eaves, R; Korman, MG, 1982) |
| "This long-term study in a patient with Barrett's esophagus showed 1) that cimetidine can be effective in treating such patients; 2) the prophylactic value of multitherapy as a maintenance regimen, and 3) the importance of careful follow-up." | 5.27 | Prolonged cimetidine therapy in ulcerated Barrett's columnar-lined esophagus. ( Avidor, I; Delpre, G; Glanz, I; Kadish, U, 1984) |
| "Stress ulcers were formed by a standard method after fasting and restraining each rat in a performed conduit tube and placing them in a cold room head inverted at 4 degrees C for three hours." | 5.26 | The preventive effect of cimetidine on producing stress ulcer in rats. ( Inokuchi, K; Matsumoto, T; Nakamura, T; Sufian, S; Sugimachi, K, 1978) |
| "Twenty patients took part in a controlled double blind study comparing the efficacy of colloidal bismuth and cimetidine (800 mg at night) with cimetidine alone in the treatment of ulcerative reflux oesophagitis." | 5.06 | Treatment of ulcerative reflux oesophagitis with colloidal bismuth subcitrate in combination with cimetidine. ( Beker, JA; Borkent, MV, 1988) |
| "Perhaps older drugs to treat ulcers, such as antacids, are just as effective as the newer drugs, but veterinarians have all but abandoned these drugs in favor of H2-receptor antagonists, sucralfate, and omeprazole." | 4.78 | Antiulcer therapy. ( Papich, MG, 1993) |
| "The effect of various gastric cytoprotective drugs was studied on the development of indomethacin induced intestinal ulcers." | 3.67 | The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats. ( Beró, T; Jávor, T; Mózsik, G; Németh, A, 1984) |
| "The effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on various experimental gastric ulcers and gastric secretion in experimental animals was compared with that of cimetidine and cetraxate." | 3.67 | Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals. ( Aratani, S; Enomoto, H; Kimura, K; Mimura, K; Nomura, A; Ueda, F, 1984) |
| "Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats." | 3.67 | Naloxone is protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Ligumsky, M; Marcus, H; Nitzan, M; Rosenbach, Y; Waisman, Y; Zahavi, I, 1985) |
| "The effect of cimetidine (400 mg twice a day) on the short-term healing of chronic peptic ulcer is reported." | 3.66 | Twice-a-day dosage of cimetidine in the short-term treatment of peptic ulcer. ( Eaves, R; Korman, MG, 1982) |
| "Stress ulcers are a frequently encountered problem in critically ill medical patients." | 2.37 | Stress ulcer prophylaxis in medical patients: who, what, and how much? ( Spenney, JG; Wilcox, CM, 1988) |
| "A 60-year-old woman with chronic renal failure, hyperphosphatemia, normocalcemia and hyperparathyroidism presented with skin and subcutaneous tissue necrosis over the upper lateral aspects of both thighs which became progressively worse with subsequent ulceration over the period of 1 week." | 1.29 | Calcifying panniculitis with renal failure: a new management approach. ( Elamin, EM; McDonald, AB, 1996) |
| "This long-term study in a patient with Barrett's esophagus showed 1) that cimetidine can be effective in treating such patients; 2) the prophylactic value of multitherapy as a maintenance regimen, and 3) the importance of careful follow-up." | 1.27 | Prolonged cimetidine therapy in ulcerated Barrett's columnar-lined esophagus. ( Avidor, I; Delpre, G; Glanz, I; Kadish, U, 1984) |
Research
Studies (20)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (80.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Kumazawa, T | 1 |
| Harakawa, H | 1 |
| Obase, H | 1 |
| Oiji, Y | 1 |
| Tanaka, H | 1 |
| Shuto, K | 1 |
| Ishii, A | 1 |
| Oka, T | 1 |
| Nakamizo, N | 1 |
| Brassinne, A | 1 |
| Delpre, G | 1 |
| Kadish, U | 1 |
| Glanz, I | 1 |
| Avidor, I | 1 |
| Beró, T | 1 |
| Németh, A | 1 |
| Mózsik, G | 1 |
| Jávor, T | 1 |
| Ueda, F | 1 |
| Aratani, S | 1 |
| Mimura, K | 1 |
| Kimura, K | 1 |
| Nomura, A | 1 |
| Enomoto, H | 1 |
| Khan, F | 1 |
| Parekh, A | 1 |
| Patel, S | 1 |
| Chitkara, R | 1 |
| Rehman, M | 1 |
| Goyal, R | 1 |
| Eaves, R | 1 |
| Korman, MG | 1 |
| Brier, KL | 1 |
| Dasta, JF | 1 |
| Kidwell, GA | 1 |
| Schonfeld, SA | 1 |
| Couri, D | 1 |
| Yuki, H | 1 |
| Kamato, T | 1 |
| Nishida, A | 1 |
| Ohta, M | 1 |
| Shikama, H | 1 |
| Yanagisawa, I | 1 |
| Miyata, K | 1 |
| Papich, MG | 1 |
| Elamin, EM | 1 |
| McDonald, AB | 1 |
| Kauffman, GL | 1 |
| Foley, KT | 1 |
| Grossman, MI | 1 |
| Sugimachi, K | 1 |
| Sufian, S | 1 |
| Matsumoto, T | 1 |
| Nakamura, T | 1 |
| Inokuchi, K | 1 |
| Cooper, BT | 1 |
| Barbezat, GO | 1 |
| Arias, J | 1 |
| Aller, MA | 1 |
| Lorente, L | 1 |
| Jiménez, G | 1 |
| Rodríguez, J | 1 |
| Estébanez, E | 1 |
| Gómez de Enterría, F | 1 |
| Arias, L | 1 |
| Durán, M | 1 |
| Brandau, D | 1 |
| Borowitz, SM | 1 |
| Waisman, Y | 1 |
| Dinari, G | 1 |
| Marcus, H | 1 |
| Ligumsky, M | 1 |
| Rosenbach, Y | 1 |
| Zahavi, I | 1 |
| Nitzan, M | 1 |
| Wilcox, CM | 1 |
| Spenney, JG | 1 |
| Borkent, MV | 1 |
| Beker, JA | 1 |
Reviews
3 reviews available for cimetidine and Ulcer
| Article | Year |
|---|---|
[Cimetidine treatment. Current state of the question].
Topics: Cimetidine; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Guanidines; Gynecomastia; Humans | 1980 |
Antiulcer therapy.
Topics: Animals; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cats; Cimetidine; Dog | 1993 |
Stress ulcer prophylaxis in medical patients: who, what, and how much?
Topics: Antacids; Cimetidine; Enteral Nutrition; Gastrointestinal Hemorrhage; Humans; Ranitidine; Risk Facto | 1988 |
Trials
1 trial available for cimetidine and Ulcer
| Article | Year |
|---|---|
Treatment of ulcerative reflux oesophagitis with colloidal bismuth subcitrate in combination with cimetidine.
Topics: Aged; Anti-Ulcer Agents; Campylobacter Infections; Cimetidine; Clinical Trials as Topic; Double-Blin | 1988 |
Other Studies
16 other studies available for cimetidine and Ulcer
| Article | Year |
|---|---|
Synthesis and antiulcer activity of 5,11-dihydro[1]benzoxepino[3,4-b]pyridines.
Topics: Animals; Anti-Ulcer Agents; Benzoxepins; Gastric Acid; Pyridines; Rats; Receptors, Muscarinic; Stres | 1988 |
Visions of drug discovery. Cimetidine (Tagamet).
Topics: Anti-Ulcer Agents; Cimetidine; Drug Discovery; History, 20th Century; History, 21st Century; Humans; | 2009 |
Prolonged cimetidine therapy in ulcerated Barrett's columnar-lined esophagus.
Topics: Aged; Aluminum Hydroxide; Barrett Esophagus; Cimetidine; Drug Combinations; Drug Therapy, Combinatio | 1984 |
The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats.
Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Indomethacin; Intestinal Diseases; | 1984 |
Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals.
Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidine; Female; Gastric Acid; Gastric Mucosa; | 1984 |
Results of gastric neutralization with hourly antacids and cimetidine in 320 intubated patients with respiratory failure.
Topics: Aged; Antacids; Cimetidine; Female; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Guanidin | 1981 |
Twice-a-day dosage of cimetidine in the short-term treatment of peptic ulcer.
Topics: Adult; Aged; Aluminum Hydroxide; Antacids; Cimetidine; Drug Combinations; Duodenal Ulcer; Endoscopy; | 1982 |
Cimetidine and mental confusion.
Topics: Adult; Cimetidine; Cognition Disorders; Confusion; Guanidines; Humans; Male; Ulcer | 1980 |
Antisecretory and antiulcer effects of YM020, a new H+,K(+)-ATPase inhibitor, in rats and dogs.
Topics: Administration, Oral; Animals; Cimetidine; Dogs; Dose-Response Relationship, Drug; Gastric Acid; His | 1995 |
Calcifying panniculitis with renal failure: a new management approach.
Topics: Anti-Inflammatory Agents; Biopsy, Needle; Calcinosis; Cimetidine; Drug Therapy, Combination; Female; | 1996 |
Cimetidine does not inhibit indomethacin-induced small bowel ulceration in the rat.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Cimetidine; Guanidines; Indomethacin; Intestinal Diseases; | 1979 |
The preventive effect of cimetidine on producing stress ulcer in rats.
Topics: Animals; Cimetidine; Guanidines; Male; Rats; Stress, Physiological; Ulcer | 1978 |
Treatment of Barrett's esophagus with H2 blockers.
Topics: Adult; Aged; Aged, 80 and over; Barrett Esophagus; Cimetidine; Esophageal Diseases; Female; Histamin | 1987 |
[Gastrointestinal pathology following orthotopic transplantation of the liver in the pig].
Topics: Animals; Cimetidine; Cyclosporins; Digestive System Diseases; Esophageal Diseases; Female; Histamine | 1987 |
Ulcerative esophagitis. A rare source of upper gastrointestinal bleeding in a neonate. Use of fiberoptic endoscopy for diagnosis.
Topics: Cimetidine; Esophagitis; Esophagoscopy; Female; Fiber Optic Technology; Hematemesis; Humans; Infant, | 1989 |
Naloxone is protective against indomethacin-induced intestinal ulceration in the rat.
Topics: Animals; Cimetidine; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Intes | 1985 |