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cimetidine and Ulcer

cimetidine has been researched along with Ulcer in 20 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Research Excerpts

ExcerptRelevanceReference
"Twenty patients took part in a controlled double blind study comparing the efficacy of colloidal bismuth and cimetidine (800 mg at night) with cimetidine alone in the treatment of ulcerative reflux oesophagitis."9.06Treatment of ulcerative reflux oesophagitis with colloidal bismuth subcitrate in combination with cimetidine. ( Beker, JA; Borkent, MV, 1988)
"The effect of various gastric cytoprotective drugs was studied on the development of indomethacin induced intestinal ulcers."7.67The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats. ( Beró, T; Jávor, T; Mózsik, G; Németh, A, 1984)
"Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats."7.67Naloxone is protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Ligumsky, M; Marcus, H; Nitzan, M; Rosenbach, Y; Waisman, Y; Zahavi, I, 1985)
"The effect of cimetidine (400 mg twice a day) on the short-term healing of chronic peptic ulcer is reported."7.66Twice-a-day dosage of cimetidine in the short-term treatment of peptic ulcer. ( Eaves, R; Korman, MG, 1982)
"This long-term study in a patient with Barrett's esophagus showed 1) that cimetidine can be effective in treating such patients; 2) the prophylactic value of multitherapy as a maintenance regimen, and 3) the importance of careful follow-up."5.27Prolonged cimetidine therapy in ulcerated Barrett's columnar-lined esophagus. ( Avidor, I; Delpre, G; Glanz, I; Kadish, U, 1984)
"Stress ulcers were formed by a standard method after fasting and restraining each rat in a performed conduit tube and placing them in a cold room head inverted at 4 degrees C for three hours."5.26The preventive effect of cimetidine on producing stress ulcer in rats. ( Inokuchi, K; Matsumoto, T; Nakamura, T; Sufian, S; Sugimachi, K, 1978)
"Twenty patients took part in a controlled double blind study comparing the efficacy of colloidal bismuth and cimetidine (800 mg at night) with cimetidine alone in the treatment of ulcerative reflux oesophagitis."5.06Treatment of ulcerative reflux oesophagitis with colloidal bismuth subcitrate in combination with cimetidine. ( Beker, JA; Borkent, MV, 1988)
"Perhaps older drugs to treat ulcers, such as antacids, are just as effective as the newer drugs, but veterinarians have all but abandoned these drugs in favor of H2-receptor antagonists, sucralfate, and omeprazole."4.78Antiulcer therapy. ( Papich, MG, 1993)
"The effect of various gastric cytoprotective drugs was studied on the development of indomethacin induced intestinal ulcers."3.67The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats. ( Beró, T; Jávor, T; Mózsik, G; Németh, A, 1984)
"The effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on various experimental gastric ulcers and gastric secretion in experimental animals was compared with that of cimetidine and cetraxate."3.67Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals. ( Aratani, S; Enomoto, H; Kimura, K; Mimura, K; Nomura, A; Ueda, F, 1984)
"Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats."3.67Naloxone is protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Ligumsky, M; Marcus, H; Nitzan, M; Rosenbach, Y; Waisman, Y; Zahavi, I, 1985)
"The effect of cimetidine (400 mg twice a day) on the short-term healing of chronic peptic ulcer is reported."3.66Twice-a-day dosage of cimetidine in the short-term treatment of peptic ulcer. ( Eaves, R; Korman, MG, 1982)
"Stress ulcers are a frequently encountered problem in critically ill medical patients."2.37Stress ulcer prophylaxis in medical patients: who, what, and how much? ( Spenney, JG; Wilcox, CM, 1988)
"A 60-year-old woman with chronic renal failure, hyperphosphatemia, normocalcemia and hyperparathyroidism presented with skin and subcutaneous tissue necrosis over the upper lateral aspects of both thighs which became progressively worse with subsequent ulceration over the period of 1 week."1.29Calcifying panniculitis with renal failure: a new management approach. ( Elamin, EM; McDonald, AB, 1996)
"This long-term study in a patient with Barrett's esophagus showed 1) that cimetidine can be effective in treating such patients; 2) the prophylactic value of multitherapy as a maintenance regimen, and 3) the importance of careful follow-up."1.27Prolonged cimetidine therapy in ulcerated Barrett's columnar-lined esophagus. ( Avidor, I; Delpre, G; Glanz, I; Kadish, U, 1984)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199016 (80.00)18.7374
1990's3 (15.00)18.2507
2000's1 (5.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kumazawa, T1
Harakawa, H1
Obase, H1
Oiji, Y1
Tanaka, H1
Shuto, K1
Ishii, A1
Oka, T1
Nakamizo, N1
Brassinne, A1
Delpre, G1
Kadish, U1
Glanz, I1
Avidor, I1
Beró, T1
Németh, A1
Mózsik, G1
Jávor, T1
Ueda, F1
Aratani, S1
Mimura, K1
Kimura, K1
Nomura, A1
Enomoto, H1
Khan, F1
Parekh, A1
Patel, S1
Chitkara, R1
Rehman, M1
Goyal, R1
Eaves, R1
Korman, MG1
Brier, KL1
Dasta, JF1
Kidwell, GA1
Schonfeld, SA1
Couri, D1
Yuki, H1
Kamato, T1
Nishida, A1
Ohta, M1
Shikama, H1
Yanagisawa, I1
Miyata, K1
Papich, MG1
Elamin, EM1
McDonald, AB1
Kauffman, GL1
Foley, KT1
Grossman, MI1
Sugimachi, K1
Sufian, S1
Matsumoto, T1
Nakamura, T1
Inokuchi, K1
Cooper, BT1
Barbezat, GO1
Arias, J1
Aller, MA1
Lorente, L1
Jiménez, G1
Rodríguez, J1
Estébanez, E1
Gómez de Enterría, F1
Arias, L1
Durán, M1
Brandau, D1
Borowitz, SM1
Waisman, Y1
Dinari, G1
Marcus, H1
Ligumsky, M1
Rosenbach, Y1
Zahavi, I1
Nitzan, M1
Wilcox, CM1
Spenney, JG1
Borkent, MV1
Beker, JA1

Reviews

3 reviews available for cimetidine and Ulcer

ArticleYear
[Cimetidine treatment. Current state of the question].
    Revue medicale de Liege, 1980, Apr-15, Volume: 35, Issue:8

    Topics: Cimetidine; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Guanidines; Gynecomastia; Humans

1980
Antiulcer therapy.
    The Veterinary clinics of North America. Small animal practice, 1993, Volume: 23, Issue:3

    Topics: Animals; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cats; Cimetidine; Dog

1993
Stress ulcer prophylaxis in medical patients: who, what, and how much?
    The American journal of gastroenterology, 1988, Volume: 83, Issue:11

    Topics: Antacids; Cimetidine; Enteral Nutrition; Gastrointestinal Hemorrhage; Humans; Ranitidine; Risk Facto

1988

Trials

1 trial available for cimetidine and Ulcer

ArticleYear
Treatment of ulcerative reflux oesophagitis with colloidal bismuth subcitrate in combination with cimetidine.
    Gut, 1988, Volume: 29, Issue:3

    Topics: Aged; Anti-Ulcer Agents; Campylobacter Infections; Cimetidine; Clinical Trials as Topic; Double-Blin

1988

Other Studies

16 other studies available for cimetidine and Ulcer

ArticleYear
Synthesis and antiulcer activity of 5,11-dihydro[1]benzoxepino[3,4-b]pyridines.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Benzoxepins; Gastric Acid; Pyridines; Rats; Receptors, Muscarinic; Stres

1988
Visions of drug discovery. Cimetidine (Tagamet).
    Molecular interventions, 2009, Volume: 9, Issue:1

    Topics: Anti-Ulcer Agents; Cimetidine; Drug Discovery; History, 20th Century; History, 21st Century; Humans;

2009
Prolonged cimetidine therapy in ulcerated Barrett's columnar-lined esophagus.
    The American journal of gastroenterology, 1984, Volume: 79, Issue:1

    Topics: Aged; Aluminum Hydroxide; Barrett Esophagus; Cimetidine; Drug Combinations; Drug Therapy, Combinatio

1984
The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats.
    Acta physiologica Hungarica, 1984, Volume: 64, Issue:3-4

    Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Indomethacin; Intestinal Diseases;

1984
Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:4

    Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidine; Female; Gastric Acid; Gastric Mucosa;

1984
Results of gastric neutralization with hourly antacids and cimetidine in 320 intubated patients with respiratory failure.
    Chest, 1981, Volume: 79, Issue:4

    Topics: Aged; Antacids; Cimetidine; Female; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Guanidin

1981
Twice-a-day dosage of cimetidine in the short-term treatment of peptic ulcer.
    The Medical journal of Australia, 1982, Nov-27, Volume: 2, Issue:11

    Topics: Adult; Aged; Aluminum Hydroxide; Antacids; Cimetidine; Drug Combinations; Duodenal Ulcer; Endoscopy;

1982
Cimetidine and mental confusion.
    Critical care medicine, 1980, Volume: 8, Issue:12

    Topics: Adult; Cimetidine; Cognition Disorders; Confusion; Guanidines; Humans; Male; Ulcer

1980
Antisecretory and antiulcer effects of YM020, a new H+,K(+)-ATPase inhibitor, in rats and dogs.
    Japanese journal of pharmacology, 1995, Volume: 67, Issue:1

    Topics: Administration, Oral; Animals; Cimetidine; Dogs; Dose-Response Relationship, Drug; Gastric Acid; His

1995
Calcifying panniculitis with renal failure: a new management approach.
    Dermatology (Basel, Switzerland), 1996, Volume: 192, Issue:2

    Topics: Anti-Inflammatory Agents; Biopsy, Needle; Calcinosis; Cimetidine; Drug Therapy, Combination; Female;

1996
Cimetidine does not inhibit indomethacin-induced small bowel ulceration in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1979, Volume: 161, Issue:4

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Cimetidine; Guanidines; Indomethacin; Intestinal Diseases;

1979
The preventive effect of cimetidine on producing stress ulcer in rats.
    The Japanese journal of surgery, 1978, Volume: 8, Issue:3

    Topics: Animals; Cimetidine; Guanidines; Male; Rats; Stress, Physiological; Ulcer

1978
Treatment of Barrett's esophagus with H2 blockers.
    Journal of clinical gastroenterology, 1987, Volume: 9, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Barrett Esophagus; Cimetidine; Esophageal Diseases; Female; Histamin

1987
[Gastrointestinal pathology following orthotopic transplantation of the liver in the pig].
    Revista espanola de las enfermedades del aparato digestivo, 1987, Volume: 72, Issue:3

    Topics: Animals; Cimetidine; Cyclosporins; Digestive System Diseases; Esophageal Diseases; Female; Histamine

1987
Ulcerative esophagitis. A rare source of upper gastrointestinal bleeding in a neonate. Use of fiberoptic endoscopy for diagnosis.
    Clinical pediatrics, 1989, Volume: 28, Issue:2

    Topics: Cimetidine; Esophagitis; Esophagoscopy; Female; Fiber Optic Technology; Hematemesis; Humans; Infant,

1989
Naloxone is protective against indomethacin-induced intestinal ulceration in the rat.
    Gastroenterology, 1985, Volume: 89, Issue:1

    Topics: Animals; Cimetidine; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Intes

1985