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cimetidine and Edema

cimetidine has been researched along with Edema in 27 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
"Oral cimetidine for the treatment of verruca continues to be a topic of discussion and controversy."8.80Cimetidine and a delayed hypersensitivity reaction. ( Donohoe, S; Eberly, M; Evans, RD; Yoho, R, 2000)
"The effect of three histamine H2-antagonists, cimetidine, ranitidine, and loxtidine, on acute rat paw oedema induced by histamine, carrageenan or complete Freund's adjuvant, have been examined."7.67Effect of histamine H2-receptor antagonists on acute inflammatory of the rat paw oedema. ( Ezeamuzie, CI; Umezurike, CC, 1989)
" In contrast to when mepyramine was used, there was a significant inhibition of carrageenan oedema when cimetidine was used."7.66Carrageenan-induced oedema in the rat paw - histamine participation. ( Maśliński, S; Stochla, K, 1982)
" Mepyramine maleate at a dose maximally effective on histamine-induced paw oedema (1 mg X kg-1 i."7.66Re-appraisal of the role of histamine in carrageenan-induced paw oedema. ( Al-Haboubi, HA; Zeitlin, IJ, 1983)
"Previous studies in stressed animals have shown a subjective decrease in shock-related gastric submucosal edema formation associated with the administration of H2-receptor antagonist cimetidine."7.66Cimetidine prevents gastrointestinal edema associated with stress. ( Levine, BA; Pruitt, BA; Sirinek, KR, 1980)
"Large doses of cimetidine significantly inhibit edema formation in thermally injured rat skeletal muscle."7.66Cimetidine inhibits burn edema formation. ( Ayvazian, VH; Deitz, F; Flynn, D; Monafo, WW; Yoshioka, T, 1978)
"Oral cimetidine for the treatment of verruca continues to be a topic of discussion and controversy."4.80Cimetidine and a delayed hypersensitivity reaction. ( Donohoe, S; Eberly, M; Evans, RD; Yoho, R, 2000)
" Treatment with the cytochrome P-450 inhibitor cimetidine or 8-methoxypsoralen did not improve survival or reduce lung edema in rats exposed to 100% oxygen."3.68Effects of inhibition and induction of cytochrome P-450 isozymes on hyperoxic lung injury in rats. ( Hunt, CM; Kennedy, TP; Piantadosi, CA; Todd, NW; Whorton, AR, 1992)
" The edematogenic reaction appeared 5 min after the intraplantar injection of ovalbumin, peaked at 30 min after the antigenic challenge, and decreased thereafter."3.68Effect of PAF-acether antagonists on active anaphylactic mouse paw edema. ( Amorim, CZ; Cordeiro, RS; Henriques, MG; Vargaftig, BB; Weg, VB, 1991)
"The effect of three histamine H2-antagonists, cimetidine, ranitidine, and loxtidine, on acute rat paw oedema induced by histamine, carrageenan or complete Freund's adjuvant, have been examined."3.67Effect of histamine H2-receptor antagonists on acute inflammatory of the rat paw oedema. ( Ezeamuzie, CI; Umezurike, CC, 1989)
"The pathogenesis of burn edema in the skin of rats appears to be related to a role for histamine, xanthine oxidase and oxygen radicals."3.67Roles of histamine, complement and xanthine oxidase in thermal injury of skin. ( Friedl, HP; Till, GO; Trentz, O; Ward, PA, 1989)
" In contrast to when mepyramine was used, there was a significant inhibition of carrageenan oedema when cimetidine was used."3.66Carrageenan-induced oedema in the rat paw - histamine participation. ( Maśliński, S; Stochla, K, 1982)
" Mepyramine maleate at a dose maximally effective on histamine-induced paw oedema (1 mg X kg-1 i."3.66Re-appraisal of the role of histamine in carrageenan-induced paw oedema. ( Al-Haboubi, HA; Zeitlin, IJ, 1983)
"Previous studies in stressed animals have shown a subjective decrease in shock-related gastric submucosal edema formation associated with the administration of H2-receptor antagonist cimetidine."3.66Cimetidine prevents gastrointestinal edema associated with stress. ( Levine, BA; Pruitt, BA; Sirinek, KR, 1980)
"Large doses of cimetidine significantly inhibit edema formation in thermally injured rat skeletal muscle."3.66Cimetidine inhibits burn edema formation. ( Ayvazian, VH; Deitz, F; Flynn, D; Monafo, WW; Yoshioka, T, 1978)
"The effects of the H2-antagonists, metiamide and cimetidine, on the oedema following limb ischaemia or scald have been investigated in two strains of rat."3.66H2-receptors and traumatic oedema. ( Little, RA; Savic, J; Stoner, HB, 1978)
"Docetaxel is active for metastatic breast cancer."2.68Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer. ( Balmaceda, C; Baselga, J; Bruno, R; Crown, JP; Currie, V; Freilich, R; Gilewski, TA; Gollub, M; Hakes, TB; Hudis, CA; Lebwohl, DE; Norton, L; Raptis, G; Robles, M; Seidman, AD, 1996)
" However, a number of facts involving the occurrence of gastrointestinal lesions have limited the chronic use of NSAIDs."1.32Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine. ( Cardoso, LG; Carvalho, JC; Ferreira, LR; Maciel, HP; Perazzo, FF, 2004)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199014 (51.85)18.7374
1990's8 (29.63)18.2507
2000's4 (14.81)29.6817
2010's1 (3.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Duplancic, B1
Stambolija, V1
Holjevac, J1
Zemba, M1
Balenovic, I1
Drmic, D1
Suran, J1
Radic, B1
Filipovic, M1
Blagaic, AB1
Brcic, L1
Kolenc, D1
Grabarevic, Z1
Seiwerth, S1
Sikiric, P1
Maciel, HP1
Cardoso, LG1
Ferreira, LR1
Perazzo, FF1
Carvalho, JC1
de Paula, L1
Santos, WF1
Malheiro, A1
Carlos, D1
Faccioli, LH1
Liu, T1
Bai, ZT1
Pang, XY1
Chai, ZF1
Jiang, F1
Ji, YH1
Stochla, K1
Maśliński, S1
Villar, A1
Gasco, MA1
Alcaraz, MJ1
Boykin, JV1
Eriksson, E1
Sholley, MM1
Pittman, RN1
Lundberg, JM1
Saria, A1
Rosell, S1
Folkers, K1
Casula, G1
Angioy, F1
Sirigu, P1
Scattone, S1
Uccheddu, A1
Björk, J1
Arturson, G1
Al-Haboubi, HA1
Zeitlin, IJ1
Jacob, H1
Brandt, LJ1
Berkowitz, D1
Bernstein, LH1
Levine, BA1
Sirinek, KR1
Pruitt, BA1
Winkler, T1
Sharma, HS1
Stålberg, E1
Olsson, Y1
Nyberg, F1
Hudis, CA1
Seidman, AD1
Crown, JP1
Balmaceda, C1
Freilich, R1
Gilewski, TA1
Hakes, TB1
Currie, V1
Lebwohl, DE1
Baselga, J1
Raptis, G1
Gollub, M1
Robles, M1
Bruno, R1
Norton, L1
Desouza, IA1
Ribeiro-DaSilva, G1
Rolland, Y1
Mazières, B1
Behar, M1
Kahn, MF1
Cantagrel, A1
Laroche, M1
Evans, RD1
Yoho, R1
Eberly, M1
Donohoe, S1
Yoshioka, T1
Monafo, WW1
Ayvazian, VH1
Deitz, F1
Flynn, D1
Little, RA1
Savic, J1
Stoner, HB1
Todd, NW1
Hunt, CM1
Kennedy, TP1
Piantadosi, CA1
Whorton, AR1
Amorim, CZ1
Henriques, MG1
Weg, VB1
Cordeiro, RS1
Vargaftig, BB1
Morini, G1
Ortolani, F1
Impicciatore, M1
Banks, BE1
Dempsey, CE1
Vernon, CA1
Warner, JA1
Yamey, J1
Ezeamuzie, CI1
Umezurike, CC1
Friedl, HP1
Till, GO1
Trentz, O1
Ward, PA1
Ikai, K1
Danno, K1
Horio, T1
Narumiya, S1

Reviews

1 review available for cimetidine and Edema

ArticleYear
Cimetidine and a delayed hypersensitivity reaction.
    Clinics in podiatric medicine and surgery, 2000, Volume: 17, Issue:2

    Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Cimetidine; Drug Eruptions; Edema; Female; Foll

2000

Trials

1 trial available for cimetidine and Edema

ArticleYear
Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenh

1996

Other Studies

25 other studies available for cimetidine and Edema

ArticleYear
Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration.
    European journal of pharmacology, 2014, Mar-15, Volume: 727

    Topics: Administration, Intravenous; Anaphylaxis; Animals; Anti-Allergic Agents; Cimetidine; Dextrans; Disea

2014
Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine.
    Inflammopharmacology, 2004, Volume: 12, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Drug Therapy, Combination; Edema; Indo

2004
Differential modulation of cell recruitment and acute edema in a model of Polybia paulista venom-induced inflammation.
    International immunopharmacology, 2006, Volume: 6, Issue:2

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Dose-Response Relations

2006
Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom.
    European journal of pharmacology, 2007, Dec-01, Volume: 575, Issue:1-3

    Topics: Animals; Chlorpheniramine; Cimetidine; Dose-Response Relationship, Drug; Edema; Histamine Antagonist

2007
Carrageenan-induced oedema in the rat paw - histamine participation.
    Agents and actions, 1982, Volume: 12, Issue:1-2

    Topics: Animals; Carrageenan; Cimetidine; Edema; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonis

1982
Anti-inflammatory and anti-ulcer properties of hypolaetin-8-glucoside, a novel plant flavonoid.
    The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:12

    Topics: Abscess; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen

1984
Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment.
    Science (New York, N.Y.), 1980, Aug-15, Volume: 209, Issue:4458

    Topics: Animals; Burns; Cell Membrane Permeability; Cimetidine; Cold Temperature; Edema; Guanidines; Histami

1980
A substance P antagonist inhibits heat-induced oedema in the rat skin.
    Acta physiologica Scandinavica, 1984, Volume: 120, Issue:1

    Topics: Animals; Cimetidine; Edema; Electric Stimulation; Hot Temperature; Male; Nerve Fibers; Peptide Fragm

1984
[Effect of gastrectomy on edematous pancreatitis in the mouse treated with cimetidine].
    Chirurgia e patologia sperimentale, 1983, Volume: 31, Issue:1

    Topics: Animals; Cimetidine; Drug Evaluation, Preclinical; Edema; Female; Gastrectomy; Mice; Pancreas; Pancr

1983
Effect of cimetidine, hydrocortisone superoxide dismutase and catalase on the development of oedema after thermal injury.
    Burns, including thermal injury, 1983, Volume: 9, Issue:4

    Topics: Animals; Blood Pressure; Burns; Capillary Permeability; Catalase; Cimetidine; Edema; Guanidines; Hyd

1983
Re-appraisal of the role of histamine in carrageenan-induced paw oedema.
    European journal of pharmacology, 1983, Mar-25, Volume: 88, Issue:2-3

    Topics: Animals; Carrageenan; Cimetidine; Edema; Histamine; Indomethacin; Male; Rats; Rats, Inbred Strains;

1983
Massive hemorrhage from suture line ulceration: documentation by endoscopy.
    Gastrointestinal endoscopy, 1982, Volume: 28, Issue:3

    Topics: Cimetidine; Edema; Endoscopes; Endoscopy; Female; Gastrectomy; Hematemesis; Humans; Middle Aged; Sto

1982
Cimetidine prevents gastrointestinal edema associated with stress.
    The Journal of trauma, 1980, Volume: 20, Issue:6

    Topics: Animals; Blood Urea Nitrogen; Body Water; Cimetidine; Cold Temperature; Edema; Fasting; Female; Gast

1980
Role of histamine in spinal cord evoked potentials and edema following spinal cord injury: experimental observations in the rat.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 1

    Topics: Animals; Cimetidine; Edema; Evoked Potentials; Histamine; Histamine H2 Antagonists; Male; Rats; Rats

1995
The pharmacological profile of mouse hind paw inflammation induced by staphylococcal enterotoxin type A.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46, Issue:9

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Capsaicin; Cimetidi

1997
Does the atopic ("allergic") rheumatism of NERDS really exist? Report of a case.
    Revue du rhumatisme (English ed.), 1997, Volume: 64, Issue:10

    Topics: Adult; Cetirizine; Cimetidine; Dermatitis; Diagnosis, Differential; Edema; Eosinophilia; Follow-Up S

1997
Cimetidine inhibits burn edema formation.
    American journal of surgery, 1978, Volume: 136, Issue:6

    Topics: Animals; Burns; Cimetidine; Dose-Response Relationship, Drug; Edema; Guanidines; Potassium; Rats; So

1978
H2-receptors and traumatic oedema.
    The Journal of pathology, 1978, Volume: 125, Issue:4

    Topics: Animals; Body Temperature; Burns; Cimetidine; Depression, Chemical; Edema; Guanidines; Male; Metiami

1978
Effects of inhibition and induction of cytochrome P-450 isozymes on hyperoxic lung injury in rats.
    American journal of respiratory cell and molecular biology, 1992, Volume: 7, Issue:2

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cimetidine; Cytochrome P-450 CYP1A1;

1992
Effect of PAF-acether antagonists on active anaphylactic mouse paw edema.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; A

1991
Histological examination of gastric mucosal lesions induced by isolation in saline and cimetidine treated rat.
    The Italian journal of gastroenterology, 1990, Volume: 22, Issue:6

    Topics: Animals; Cimetidine; Edema; Epithelium; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Hyperem

1990
Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo.
    British journal of pharmacology, 1990, Volume: 99, Issue:2

    Topics: Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bee Venoms; Carrageenan; Cimetidine; Cy

1990
Effect of histamine H2-receptor antagonists on acute inflammatory of the rat paw oedema.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cimetidine; Edema; Freund's Adjuvant;

1989
Roles of histamine, complement and xanthine oxidase in thermal injury of skin.
    The American journal of pathology, 1989, Volume: 135, Issue:1

    Topics: Animals; Burns; Cimetidine; Complement Inactivator Proteins; Complement System Proteins; Cromolyn So

1989
Ear swelling in response to UVB irradiation.
    Archives of dermatological research, 1986, Volume: 278, Issue:6

    Topics: Animals; Betamethasone; Cimetidine; Diphenhydramine; Ear, External; Edema; Erythema; Indomethacin; M

1986