cimetidine and Edema
cimetidine has been researched along with Edema in 27 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral cimetidine for the treatment of verruca continues to be a topic of discussion and controversy." | 8.80 | Cimetidine and a delayed hypersensitivity reaction. ( Donohoe, S; Eberly, M; Evans, RD; Yoho, R, 2000) |
| "The effect of three histamine H2-antagonists, cimetidine, ranitidine, and loxtidine, on acute rat paw oedema induced by histamine, carrageenan or complete Freund's adjuvant, have been examined." | 7.67 | Effect of histamine H2-receptor antagonists on acute inflammatory of the rat paw oedema. ( Ezeamuzie, CI; Umezurike, CC, 1989) |
| " In contrast to when mepyramine was used, there was a significant inhibition of carrageenan oedema when cimetidine was used." | 7.66 | Carrageenan-induced oedema in the rat paw - histamine participation. ( Maśliński, S; Stochla, K, 1982) |
| " Mepyramine maleate at a dose maximally effective on histamine-induced paw oedema (1 mg X kg-1 i." | 7.66 | Re-appraisal of the role of histamine in carrageenan-induced paw oedema. ( Al-Haboubi, HA; Zeitlin, IJ, 1983) |
| "Previous studies in stressed animals have shown a subjective decrease in shock-related gastric submucosal edema formation associated with the administration of H2-receptor antagonist cimetidine." | 7.66 | Cimetidine prevents gastrointestinal edema associated with stress. ( Levine, BA; Pruitt, BA; Sirinek, KR, 1980) |
| "Large doses of cimetidine significantly inhibit edema formation in thermally injured rat skeletal muscle." | 7.66 | Cimetidine inhibits burn edema formation. ( Ayvazian, VH; Deitz, F; Flynn, D; Monafo, WW; Yoshioka, T, 1978) |
| "Oral cimetidine for the treatment of verruca continues to be a topic of discussion and controversy." | 4.80 | Cimetidine and a delayed hypersensitivity reaction. ( Donohoe, S; Eberly, M; Evans, RD; Yoho, R, 2000) |
| " Treatment with the cytochrome P-450 inhibitor cimetidine or 8-methoxypsoralen did not improve survival or reduce lung edema in rats exposed to 100% oxygen." | 3.68 | Effects of inhibition and induction of cytochrome P-450 isozymes on hyperoxic lung injury in rats. ( Hunt, CM; Kennedy, TP; Piantadosi, CA; Todd, NW; Whorton, AR, 1992) |
| " The edematogenic reaction appeared 5 min after the intraplantar injection of ovalbumin, peaked at 30 min after the antigenic challenge, and decreased thereafter." | 3.68 | Effect of PAF-acether antagonists on active anaphylactic mouse paw edema. ( Amorim, CZ; Cordeiro, RS; Henriques, MG; Vargaftig, BB; Weg, VB, 1991) |
| "The effect of three histamine H2-antagonists, cimetidine, ranitidine, and loxtidine, on acute rat paw oedema induced by histamine, carrageenan or complete Freund's adjuvant, have been examined." | 3.67 | Effect of histamine H2-receptor antagonists on acute inflammatory of the rat paw oedema. ( Ezeamuzie, CI; Umezurike, CC, 1989) |
| "The pathogenesis of burn edema in the skin of rats appears to be related to a role for histamine, xanthine oxidase and oxygen radicals." | 3.67 | Roles of histamine, complement and xanthine oxidase in thermal injury of skin. ( Friedl, HP; Till, GO; Trentz, O; Ward, PA, 1989) |
| " In contrast to when mepyramine was used, there was a significant inhibition of carrageenan oedema when cimetidine was used." | 3.66 | Carrageenan-induced oedema in the rat paw - histamine participation. ( Maśliński, S; Stochla, K, 1982) |
| " Mepyramine maleate at a dose maximally effective on histamine-induced paw oedema (1 mg X kg-1 i." | 3.66 | Re-appraisal of the role of histamine in carrageenan-induced paw oedema. ( Al-Haboubi, HA; Zeitlin, IJ, 1983) |
| "Previous studies in stressed animals have shown a subjective decrease in shock-related gastric submucosal edema formation associated with the administration of H2-receptor antagonist cimetidine." | 3.66 | Cimetidine prevents gastrointestinal edema associated with stress. ( Levine, BA; Pruitt, BA; Sirinek, KR, 1980) |
| "Large doses of cimetidine significantly inhibit edema formation in thermally injured rat skeletal muscle." | 3.66 | Cimetidine inhibits burn edema formation. ( Ayvazian, VH; Deitz, F; Flynn, D; Monafo, WW; Yoshioka, T, 1978) |
| "The effects of the H2-antagonists, metiamide and cimetidine, on the oedema following limb ischaemia or scald have been investigated in two strains of rat." | 3.66 | H2-receptors and traumatic oedema. ( Little, RA; Savic, J; Stoner, HB, 1978) |
| "Docetaxel is active for metastatic breast cancer." | 2.68 | Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer. ( Balmaceda, C; Baselga, J; Bruno, R; Crown, JP; Currie, V; Freilich, R; Gilewski, TA; Gollub, M; Hakes, TB; Hudis, CA; Lebwohl, DE; Norton, L; Raptis, G; Robles, M; Seidman, AD, 1996) |
| " However, a number of facts involving the occurrence of gastrointestinal lesions have limited the chronic use of NSAIDs." | 1.32 | Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine. ( Cardoso, LG; Carvalho, JC; Ferreira, LR; Maciel, HP; Perazzo, FF, 2004) |
Research
Studies (27)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (51.85) | 18.7374 |
| 1990's | 8 (29.63) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Duplancic, B | 1 |
| Stambolija, V | 1 |
| Holjevac, J | 1 |
| Zemba, M | 1 |
| Balenovic, I | 1 |
| Drmic, D | 1 |
| Suran, J | 1 |
| Radic, B | 1 |
| Filipovic, M | 1 |
| Blagaic, AB | 1 |
| Brcic, L | 1 |
| Kolenc, D | 1 |
| Grabarevic, Z | 1 |
| Seiwerth, S | 1 |
| Sikiric, P | 1 |
| Maciel, HP | 1 |
| Cardoso, LG | 1 |
| Ferreira, LR | 1 |
| Perazzo, FF | 1 |
| Carvalho, JC | 1 |
| de Paula, L | 1 |
| Santos, WF | 1 |
| Malheiro, A | 1 |
| Carlos, D | 1 |
| Faccioli, LH | 1 |
| Liu, T | 1 |
| Bai, ZT | 1 |
| Pang, XY | 1 |
| Chai, ZF | 1 |
| Jiang, F | 1 |
| Ji, YH | 1 |
| Stochla, K | 1 |
| Maśliński, S | 1 |
| Villar, A | 1 |
| Gasco, MA | 1 |
| Alcaraz, MJ | 1 |
| Boykin, JV | 1 |
| Eriksson, E | 1 |
| Sholley, MM | 1 |
| Pittman, RN | 1 |
| Lundberg, JM | 1 |
| Saria, A | 1 |
| Rosell, S | 1 |
| Folkers, K | 1 |
| Casula, G | 1 |
| Angioy, F | 1 |
| Sirigu, P | 1 |
| Scattone, S | 1 |
| Uccheddu, A | 1 |
| Björk, J | 1 |
| Arturson, G | 1 |
| Al-Haboubi, HA | 1 |
| Zeitlin, IJ | 1 |
| Jacob, H | 1 |
| Brandt, LJ | 1 |
| Berkowitz, D | 1 |
| Bernstein, LH | 1 |
| Levine, BA | 1 |
| Sirinek, KR | 1 |
| Pruitt, BA | 1 |
| Winkler, T | 1 |
| Sharma, HS | 1 |
| Stålberg, E | 1 |
| Olsson, Y | 1 |
| Nyberg, F | 1 |
| Hudis, CA | 1 |
| Seidman, AD | 1 |
| Crown, JP | 1 |
| Balmaceda, C | 1 |
| Freilich, R | 1 |
| Gilewski, TA | 1 |
| Hakes, TB | 1 |
| Currie, V | 1 |
| Lebwohl, DE | 1 |
| Baselga, J | 1 |
| Raptis, G | 1 |
| Gollub, M | 1 |
| Robles, M | 1 |
| Bruno, R | 1 |
| Norton, L | 1 |
| Desouza, IA | 1 |
| Ribeiro-DaSilva, G | 1 |
| Rolland, Y | 1 |
| Mazières, B | 1 |
| Behar, M | 1 |
| Kahn, MF | 1 |
| Cantagrel, A | 1 |
| Laroche, M | 1 |
| Evans, RD | 1 |
| Yoho, R | 1 |
| Eberly, M | 1 |
| Donohoe, S | 1 |
| Yoshioka, T | 1 |
| Monafo, WW | 1 |
| Ayvazian, VH | 1 |
| Deitz, F | 1 |
| Flynn, D | 1 |
| Little, RA | 1 |
| Savic, J | 1 |
| Stoner, HB | 1 |
| Todd, NW | 1 |
| Hunt, CM | 1 |
| Kennedy, TP | 1 |
| Piantadosi, CA | 1 |
| Whorton, AR | 1 |
| Amorim, CZ | 1 |
| Henriques, MG | 1 |
| Weg, VB | 1 |
| Cordeiro, RS | 1 |
| Vargaftig, BB | 1 |
| Morini, G | 1 |
| Ortolani, F | 1 |
| Impicciatore, M | 1 |
| Banks, BE | 1 |
| Dempsey, CE | 1 |
| Vernon, CA | 1 |
| Warner, JA | 1 |
| Yamey, J | 1 |
| Ezeamuzie, CI | 1 |
| Umezurike, CC | 1 |
| Friedl, HP | 1 |
| Till, GO | 1 |
| Trentz, O | 1 |
| Ward, PA | 1 |
| Ikai, K | 1 |
| Danno, K | 1 |
| Horio, T | 1 |
| Narumiya, S | 1 |
Reviews
1 review available for cimetidine and Edema
| Article | Year |
|---|---|
Cimetidine and a delayed hypersensitivity reaction.
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Cimetidine; Drug Eruptions; Edema; Female; Foll | 2000 |
Trials
1 trial available for cimetidine and Edema
| Article | Year |
|---|---|
Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenh | 1996 |
Other Studies
25 other studies available for cimetidine and Edema
| Article | Year |
|---|---|
Pentadecapeptide BPC 157 and anaphylactoid reaction in rats and mice after intravenous dextran and white egg administration.
Topics: Administration, Intravenous; Anaphylaxis; Animals; Anti-Allergic Agents; Cimetidine; Dextrans; Disea | 2014 |
Anti-inflammatory and ulcerogenic effects of indomethacin and tenoxicam in combination with cimetidine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Drug Therapy, Combination; Edema; Indo | 2004 |
Differential modulation of cell recruitment and acute edema in a model of Polybia paulista venom-induced inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Dose-Response Relations | 2006 |
Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom.
Topics: Animals; Chlorpheniramine; Cimetidine; Dose-Response Relationship, Drug; Edema; Histamine Antagonist | 2007 |
Carrageenan-induced oedema in the rat paw - histamine participation.
Topics: Animals; Carrageenan; Cimetidine; Edema; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonis | 1982 |
Anti-inflammatory and anti-ulcer properties of hypolaetin-8-glucoside, a novel plant flavonoid.
Topics: Abscess; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agen | 1984 |
Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment.
Topics: Animals; Burns; Cell Membrane Permeability; Cimetidine; Cold Temperature; Edema; Guanidines; Histami | 1980 |
A substance P antagonist inhibits heat-induced oedema in the rat skin.
Topics: Animals; Cimetidine; Edema; Electric Stimulation; Hot Temperature; Male; Nerve Fibers; Peptide Fragm | 1984 |
[Effect of gastrectomy on edematous pancreatitis in the mouse treated with cimetidine].
Topics: Animals; Cimetidine; Drug Evaluation, Preclinical; Edema; Female; Gastrectomy; Mice; Pancreas; Pancr | 1983 |
Effect of cimetidine, hydrocortisone superoxide dismutase and catalase on the development of oedema after thermal injury.
Topics: Animals; Blood Pressure; Burns; Capillary Permeability; Catalase; Cimetidine; Edema; Guanidines; Hyd | 1983 |
Re-appraisal of the role of histamine in carrageenan-induced paw oedema.
Topics: Animals; Carrageenan; Cimetidine; Edema; Histamine; Indomethacin; Male; Rats; Rats, Inbred Strains; | 1983 |
Massive hemorrhage from suture line ulceration: documentation by endoscopy.
Topics: Cimetidine; Edema; Endoscopes; Endoscopy; Female; Gastrectomy; Hematemesis; Humans; Middle Aged; Sto | 1982 |
Cimetidine prevents gastrointestinal edema associated with stress.
Topics: Animals; Blood Urea Nitrogen; Body Water; Cimetidine; Cold Temperature; Edema; Fasting; Female; Gast | 1980 |
Role of histamine in spinal cord evoked potentials and edema following spinal cord injury: experimental observations in the rat.
Topics: Animals; Cimetidine; Edema; Evoked Potentials; Histamine; Histamine H2 Antagonists; Male; Rats; Rats | 1995 |
The pharmacological profile of mouse hind paw inflammation induced by staphylococcal enterotoxin type A.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Capsaicin; Cimetidi | 1997 |
Does the atopic ("allergic") rheumatism of NERDS really exist? Report of a case.
Topics: Adult; Cetirizine; Cimetidine; Dermatitis; Diagnosis, Differential; Edema; Eosinophilia; Follow-Up S | 1997 |
Cimetidine inhibits burn edema formation.
Topics: Animals; Burns; Cimetidine; Dose-Response Relationship, Drug; Edema; Guanidines; Potassium; Rats; So | 1978 |
H2-receptors and traumatic oedema.
Topics: Animals; Body Temperature; Burns; Cimetidine; Depression, Chemical; Edema; Guanidines; Male; Metiami | 1978 |
Effects of inhibition and induction of cytochrome P-450 isozymes on hyperoxic lung injury in rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cimetidine; Cytochrome P-450 CYP1A1; | 1992 |
Effect of PAF-acether antagonists on active anaphylactic mouse paw edema.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; A | 1991 |
Histological examination of gastric mucosal lesions induced by isolation in saline and cimetidine treated rat.
Topics: Animals; Cimetidine; Edema; Epithelium; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Hyperem | 1990 |
Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo.
Topics: Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bee Venoms; Carrageenan; Cimetidine; Cy | 1990 |
Effect of histamine H2-receptor antagonists on acute inflammatory of the rat paw oedema.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cimetidine; Edema; Freund's Adjuvant; | 1989 |
Roles of histamine, complement and xanthine oxidase in thermal injury of skin.
Topics: Animals; Burns; Cimetidine; Complement Inactivator Proteins; Complement System Proteins; Cromolyn So | 1989 |
Ear swelling in response to UVB irradiation.
Topics: Animals; Betamethasone; Cimetidine; Diphenhydramine; Ear, External; Edema; Erythema; Indomethacin; M | 1986 |