cimetidine and Acute Brain Injuries
cimetidine has been researched along with Acute Brain Injuries in 10 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The possibility that histamine plays a role in the formation of traumatic brain edema was investigated in the rat." | 7.67 | Role of histamine in traumatic brain edema. An experimental study in the rat. ( Chansouria, JP; Dey, PK; Mohanty, S; Olsson, Y; Sharma, HS; Singh, S, 1989) |
| "The possibility that histamine plays a role in the formation of traumatic brain edema was investigated in the rat." | 3.67 | Role of histamine in traumatic brain edema. An experimental study in the rat. ( Chansouria, JP; Dey, PK; Mohanty, S; Olsson, Y; Sharma, HS; Singh, S, 1989) |
| "Cimetidine prophylaxis was not shown to reduce the incidence of these lesions in this study but did diminish their severity and the likelihood that they would complicate the management of these patients." | 2.65 | Prevention of acute gastrointestinal complications after severe head injury: a controlled trial of cimetidine prophylaxis. ( Gayle, WE; Halloran, LG; Miller, JD; Wheeler, CB; Zfass, AM, 1980) |
| "Cimetidine disposition was best described by a biphasic elimination curve with t1/2 values for cimetidine, cimetidine sulfoxide, and hydroxymethyl cimetidine of 1." | 1.27 | Pharmacokinetics and pharmacodynamics of cimetidine and metabolites in critically ill children. ( Hauser, AR; Lloyd, CW; Martin, WJ; Taylor, BD, 1985) |
| "The pharmacokinetic behavior of cimetidine has not been described in children, and there is no authoritative guideline on cimetidine dosage for children." | 1.26 | Pharmacokinetics of cimetidine in critically ill children. ( Baltodano, A; Chin, TW; Edmonds, JF; Fenje, P; MacLeod, SM; Soldin, SJ, 1982) |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (90.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Silvestri, N | 1 |
| Curzio, M | 1 |
| Motta, U | 1 |
| de Pietri, P | 1 |
| Bonacina, F | 1 |
| Minoja, G | 1 |
| Holtermüller, KH | 1 |
| Ebener, B | 1 |
| Kühl, HJ | 1 |
| Rolfs, A | 1 |
| Mouawad, E | 1 |
| Deloof, T | 1 |
| Genette, F | 1 |
| Vandesteene, A | 1 |
| Chin, TW | 1 |
| MacLeod, SM | 1 |
| Fenje, P | 1 |
| Baltodano, A | 1 |
| Edmonds, JF | 1 |
| Soldin, SJ | 1 |
| Halloran, LG | 1 |
| Zfass, AM | 1 |
| Gayle, WE | 1 |
| Wheeler, CB | 1 |
| Miller, JD | 1 |
| Lareng, L | 1 |
| Jeannot, MJ | 1 |
| Clergue, ML | 1 |
| Scavazza, R | 1 |
| Fouet, P | 1 |
| Elefterion, A | 1 |
| Patnaik, R | 1 |
| Mohanty, S | 2 |
| Sharma, HS | 2 |
| Dey, PK | 1 |
| Singh, S | 1 |
| Chansouria, JP | 1 |
| Olsson, Y | 1 |
| Senoo, K | 1 |
| Ookubo, T | 1 |
| Sugimoto, M | 1 |
| Nara, M | 1 |
| Lloyd, CW | 1 |
| Martin, WJ | 1 |
| Taylor, BD | 1 |
| Hauser, AR | 1 |
Trials
2 trials available for cimetidine and Acute Brain Injuries
| Article | Year |
|---|---|
Cimetidine to prevent stress ulcers.
Topics: Adult; Brain Injuries; Cimetidine; Clinical Trials as Topic; Female; Guanidines; Humans; Male; Middl | 1980 |
Prevention of acute gastrointestinal complications after severe head injury: a controlled trial of cimetidine prophylaxis.
Topics: Adolescent; Adult; Brain Injuries; Child; Cimetidine; Clinical Trials as Topic; Double-Blind Method; | 1980 |
Other Studies
8 other studies available for cimetidine and Acute Brain Injuries
| Article | Year |
|---|---|
[Stress ulcerations: pathogenesis and prevention].
Topics: Animals; Antacids; Brain Injuries; Burns; Cimetidine; Histamine H2 Antagonists; Humans; Peptic Ulcer | 1983 |
Open trial of cimetidine in the prevention of upper gastro-intestinal haemorrhage in patients with severe intracranial injury.
Topics: Adolescent; Adult; Aged; Brain Injuries; Cimetidine; Drug Evaluation; Female; Gastrointestinal Hemor | 1983 |
Pharmacokinetics of cimetidine in critically ill children.
Topics: Age Factors; Brain Injuries; Child; Child, Preschool; Cimetidine; Gastric Acidity Determination; Hal | 1982 |
[Cimetidine and gastric secretion in acutely ill neurosurgical patients].
Topics: Adolescent; Adult; Aged; Brain Diseases; Brain Injuries; Cimetidine; Gastric Juice; Guanidines; Huma | 1982 |
Blockade of histamine H2 receptors attenuate blood-brain barrier permeability, cerebral blood flow disturbances, edema formation and cell reactions following hyperthermic brain injury in the rat.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Capillary Permeability; Cimetidine | 2000 |
Role of histamine in traumatic brain edema. An experimental study in the rat.
Topics: Animals; Brain Edema; Brain Injuries; Cimetidine; Histamine; Male; Pyrilamine; Rats; Rats, Inbred St | 1989 |
[Prophylactic effect of anti-ulcerative drugs on acute upper gastrointestinal lesions (AUGL) associated with cerebro-vascular disease (OVD) and head trauma].
Topics: Adult; Aged; Aluminum Hydroxide; Brain Injuries; Cerebrovascular Disorders; Cimetidine; Drug Combina | 1986 |
Pharmacokinetics and pharmacodynamics of cimetidine and metabolites in critically ill children.
Topics: Adolescent; Brain Injuries; Child; Child, Preschool; Cimetidine; Critical Care; Female; Humans; Kine | 1985 |