Page last updated: 2024-10-16

choline and Heart Failure

choline has been researched along with Heart Failure in 32 studies

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF)."8.02Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. ( Alonso-Gómez, A; Bulló, M; Clish, C; Corella, D; Estruch, R; Fiol, M; Fitó, M; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Li, J; Liang, L; Martínez-González, MA; Papandreou, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Santos-Lozano, JM; Serra-Majem, L; Toledo, E, 2021)
"We had previously reported an increase in trimethylamine N-oxide (TMAO) levels in patients with both compensated and decompensated heart failure (HF) and alteration in gut microbiota composition using 16S rRNA gene amplicon analysis."8.02Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure. ( Emoto, T; Gotoh, Y; Hayashi, T; Hirata, KI; Kami, K; Matsumoto, K; Saito, Y; Tabata, T; Takahashi, T; Tanaka, H; Watanabe, H; Yamada, T; Yamashita, T; Yoshida, N, 2021)
"A high-choline diet exacerbates cardiac dysfunction, myocardial fibrosis, and inflammation in HFpEF mice, and 3,3-dimethyl-1-butanol ameliorates the high-choline diet-induced cardiac remodeling."7.96High-Choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. ( Li, X; Li, Y; Shuai, W; Wang, D; Wen, J; Xiang, J, 2020)
"Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis."7.83Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016)
"A panel of gut-related biomarkers including metabolites of the choline/carnitine- pathway (acetyl-L-carnitine, betaine, choline, γ-butyrobetaine, L-carnitine and trimethylamine-N-oxide [TMAO]) and the gut peptide, Trefoil factor-3 (TFF-3), were investigated in 1,783 patients with worsening HF enrolled in the systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF) cohort and associations with HF severity and outcomes, and use in risk stratification were assessed."4.12Surrogate markers of gut dysfunction are related to heart failure severity and outcome-from the BIOSTAT-CHF consortium. ( Anker, SD; Cleland, JG; Israr, MZ; Lang, CC; Metra, M; Ng, LL; Salzano, A; Samani, NJ; Suzuki, T; van Veldhuisen, DJ; Voors, AA; Zannad, F; Zhan, H, 2022)
"Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF)."4.02Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. ( Alonso-Gómez, A; Bulló, M; Clish, C; Corella, D; Estruch, R; Fiol, M; Fitó, M; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Li, J; Liang, L; Martínez-González, MA; Papandreou, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Santos-Lozano, JM; Serra-Majem, L; Toledo, E, 2021)
"Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes."4.02Association of gut-related metabolites with outcome in acute heart failure. ( Bernieh, D; Cassambai, S; Heaney, LM; Israr, MZ; Jones, DJL; Ng, LL; Salzano, A; Suzuki, T; Yazaki, Y, 2021)
"We had previously reported an increase in trimethylamine N-oxide (TMAO) levels in patients with both compensated and decompensated heart failure (HF) and alteration in gut microbiota composition using 16S rRNA gene amplicon analysis."4.02Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure. ( Emoto, T; Gotoh, Y; Hayashi, T; Hirata, KI; Kami, K; Matsumoto, K; Saito, Y; Tabata, T; Takahashi, T; Tanaka, H; Watanabe, H; Yamada, T; Yamashita, T; Yoshida, N, 2021)
"Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine."3.96Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure. ( Goodchild, TT; Gupta, N; Hazen, SL; Lefer, DJ; Li, Z; Organ, CL; Polhemus, DJ; Sharp, TE; Tang, WHW, 2020)
"A high-choline diet exacerbates cardiac dysfunction, myocardial fibrosis, and inflammation in HFpEF mice, and 3,3-dimethyl-1-butanol ameliorates the high-choline diet-induced cardiac remodeling."3.96High-Choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. ( Li, X; Li, Y; Shuai, W; Wang, D; Wen, J; Xiang, J, 2020)
"To determine if differences exist in plasma concentrations of TMAO, choline, or l-carnitine among dogs with DMVD and congestive heart failure (CHF), dogs with asymptomatic DMVD, and healthy control dogs."3.91A pilot study investigating circulating trimethylamine N-oxide and its precursors in dogs with degenerative mitral valve disease with or without congestive heart failure. ( Freeman, LM; Karlin, ET; Rush, JE, 2019)
"Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis."3.83Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016)
" Thirty-nine dogs were divided into five groups: rapid atrial pacing (RAP), chronic mitral regurgitation (MR), congestive heart failure (CHF), methylcholine (Meth), and control."3.73Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling. ( Everett, TH; Foreman, S; Guerra, JM; Olgin, JE; Verheule, S; Wilson, EE, 2006)
"Choline was not a marker for myocardial necrosis but indicated high-risk unstable angina in patients without acute myocardial infarction (sensitivity 86."1.32Prognostic implications of elevated whole blood choline levels in acute coronary syndromes. ( Danne, O; Frei, U; Lueders, C; Lufft, H; Möckel, M; Mügge, C; Müller, C; Zschunke, GA, 2003)
"The creatine level was independently correlated with half-recovery time and duration of heart failure symptoms in PWM (r = -0."1.30Cerebral metabolic abnormalities in congestive heart failure detected by proton magnetic resonance spectroscopy. ( Hong, MK; Kim, JJ; Kim, ST; Lee, CW; Lee, JH; Lim, TH; Park, SJ; Park, SW, 1999)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19909 (28.13)18.7374
1990's1 (3.13)18.2507
2000's5 (15.63)29.6817
2010's4 (12.50)24.3611
2020's13 (40.63)2.80

Authors

AuthorsStudies
Lv, S1
Wang, Y1
Zhang, W1
Shang, H1
Bin-Jumah, MN1
Gilani, SJ1
Hosawi, S1
Al-Abbasi, FA1
Zeyadi, M1
Imam, SS1
Alshehri, S1
Ghoneim, MM1
Nadeem, MS1
Kazmi, I1
Israr, MZ3
Zhan, H1
Salzano, A3
Voors, AA1
Cleland, JG1
Anker, SD1
Metra, M1
van Veldhuisen, DJ1
Lang, CC1
Zannad, F1
Samani, NJ1
Ng, LL2
Suzuki, T3
Cassambai, S2
Yazaki, Y2
Bernieh, D2
Wong, M1
Wargny, M1
Croyal, M1
Ragot, S1
Gand, E1
Jacobi, D1
Trochu, JN1
Prieur, X1
Le May, C1
Goronflot, T1
Cariou, B1
Saulnier, PJ1
Hadjadj, S1
Yoshida, Y2
Shimizu, I1
Shimada, A1
Nakahara, K1
Yanagisawa, S1
Kubo, M1
Fukuda, S1
Ishii, C1
Yamamoto, H1
Ishikawa, T1
Kano, K1
Aoki, J1
Katsuumi, G1
Suda, M1
Ozaki, K1
Okuda, S1
Ohta, S1
Okamoto, S1
Minokoshi, Y1
Oda, K1
Sasaoka, T1
Abe, M1
Sakimura, K1
Kubota, Y1
Yoshimura, N1
Kajimura, S1
Zuriaga, M1
Walsh, K1
Soga, T1
Minamino, T1
Organ, CL2
Li, Z1
Sharp, TE1
Polhemus, DJ2
Gupta, N1
Goodchild, TT1
Tang, WHW1
Hazen, SL2
Lefer, DJ2
Shuai, W1
Wen, J1
Li, X1
Wang, D1
Li, Y1
Xiang, J1
Esposito, G1
Schiattarella, GG1
Papandreou, C1
Bulló, M1
Hernández-Alonso, P1
Ruiz-Canela, M1
Li, J1
Guasch-Ferré, M1
Toledo, E1
Clish, C1
Corella, D1
Estruch, R1
Ros, E1
Fitó, M1
Alonso-Gómez, A1
Fiol, M1
Santos-Lozano, JM1
Serra-Majem, L1
Liang, L1
Martínez-González, MA1
Hu, FB1
Salas-Salvadó, J1
Heaney, LM1
Jones, DJL1
Emoto, T1
Hayashi, T2
Tabata, T1
Yamashita, T1
Watanabe, H1
Takahashi, T1
Gotoh, Y1
Kami, K1
Yoshida, N1
Saito, Y1
Tanaka, H1
Matsumoto, K1
Yamada, T1
Hirata, KI1
Wei, H1
Zhao, M1
Huang, M1
Li, C1
Gao, J1
Yu, T1
Zhang, Q1
Shen, X1
Ji, L1
Ni, L1
Zhao, C1
Wang, Z2
Dong, E1
Zheng, L1
Wang, DW1
Karlin, ET1
Rush, JE1
Freeman, LM1
SANDRI, A1
Woo, MA1
Yadav, SK1
Macey, PM1
Fonarow, GC1
Harper, RM1
Kumar, R1
Trøseid, M1
Ueland, T1
Hov, JR1
Svardal, A1
Gregersen, I1
Dahl, CP1
Aakhus, S1
Gude, E1
Bjørndal, B1
Halvorsen, B1
Karlsen, TH1
Aukrust, P1
Gullestad, L1
Berge, RK1
Yndestad, A1
Otsuka, H1
Bhushan, S1
Bradley, J1
Trivedi, R1
Tang, WH1
Wu, Y1
Danne, O1
Möckel, M1
Lueders, C1
Mügge, C1
Zschunke, GA1
Lufft, H1
Müller, C1
Frei, U1
GOVIER, WM1
FREYBURGER, WA1
GIBBONS, AJ1
HOWES, BG1
SMITS, E1
PEARSON, S1
HAAR, H1
BROH-KAHN, RH1
McGAVACK, TH1
BATTERMAN, RC2
GROSSMAN, AJ1
BLACKMAN, AL2
BROOKS, AM1
SCHWIMMER, J2
CROSSMAN, AJ1
PELECH, JT1
VALERIO, VM1
FROLLO, A1
Lee, CW3
Lee, JH3
Yang, HS2
Lim, KH1
Ahn, JM1
Hong, MK3
Park, SW3
Park, SJ3
Song, MG1
Kim, JJ3
Everett, TH1
Wilson, EE1
Verheule, S1
Guerra, JM1
Foreman, S1
Olgin, JE1
SPADOLINI, I1
Al-Damluji, S1
Nathan, AW1
Johnston, A1
Banim, SO1
Spurrell, RA1
Camm, AJ1
Kim, ST1
Lim, TH2
Malloy, CR1
Song, JK1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
GutHeart: Targeting Gut Microbiota to Treat Heart Failure[NCT02637167]Phase 2150 participants (Anticipated)Interventional2016-03-11Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for choline and Heart Failure

ArticleYear
Trimethylamine oxide: a potential target for heart failure therapy.
    Heart (British Cardiac Society), 2022, 05-25, Volume: 108, Issue:12

    Topics: Cardiotonic Agents; Carnitine; Choline; Diuretics; Gastrointestinal Microbiome; Heart Failure; Human

2022
Pathobiological Relationship of Excessive Dietary Intake of Choline/L-Carnitine: A TMAO Precursor-Associated Aggravation in Heart Failure in Sarcopenic Patients.
    Nutrients, 2021, Sep-29, Volume: 13, Issue:10

    Topics: Biodiversity; Biomarkers; Carnitine; Choline; Dietary Supplements; Disease Susceptibility; Dysbiosis

2021
The Gut Axis Involvement in Heart Failure: Focus on Trimethylamine N-oxide.
    Cardiology clinics, 2022, Volume: 40, Issue:2

    Topics: Choline; Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines

2022

Trials

1 trial available for choline and Heart Failure

ArticleYear
Prognostic significance of cerebral metabolic abnormalities in patients with congestive heart failure.
    Circulation, 2001, Jun-12, Volume: 103, Issue:23

    Topics: Adult; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Female; Follow-Up Studies

2001

Other Studies

28 other studies available for choline and Heart Failure

ArticleYear
Surrogate markers of gut dysfunction are related to heart failure severity and outcome-from the BIOSTAT-CHF consortium.
    American heart journal, 2022, Volume: 248

    Topics: Acetylcarnitine; Biomarkers; Carnitine; Choline; Chronic Disease; Heart Failure; Humans

2022
Nutritional biomarkers and heart failure requiring hospitalization in patients with type 2 diabetes: the SURDIAGENE cohort.
    Cardiovascular diabetology, 2022, 06-09, Volume: 21, Issue:1

    Topics: Aged; Betaine; Biomarkers; Carnitine; Choline; Cohort Studies; Cysteine; Diabetes Mellitus, Type 2;

2022
Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism.
    Scientific reports, 2022, 09-01, Volume: 12, Issue:1

    Topics: Adipocytes, Brown; Adipose Tissue, Brown; Animals; Choline; Heart Failure; Methylamines; Mice; Myoca

2022
Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.
    Journal of the American Heart Association, 2020, 05-18, Volume: 9, Issue:10

    Topics: Animals; Bacteria; Bacterial Proteins; Choline; Disease Models, Animal; Down-Regulation; Enzyme Inhi

2020
High-Choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction.
    Journal of cardiac failure, 2020, Volume: 26, Issue:8

    Topics: Animals; Choline; Diet; Fibrosis; Heart Failure; Humans; Inflammation; Mice; Mice, Inbred C57BL; Str

2020
Feeding Diastolic Dysfunction: Is It a Bug?
    Journal of cardiac failure, 2020, Volume: 26, Issue:8

    Topics: Animals; Choline; Diet; Fibrosis; Heart Diseases; Heart Failure; Inflammation; Mice; Stroke Volume

2020
Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study.
    Clinical chemistry, 2021, 01-08, Volume: 67, Issue:1

    Topics: Aged; Atrial Fibrillation; Betaine; Carnitine; Case-Control Studies; Choline; Female; Heart Failure;

2021
Association of gut-related metabolites with outcome in acute heart failure.
    American heart journal, 2021, Volume: 234

    Topics: Acetylcarnitine; Acute Disease; Aged; Aged, 80 and over; Betaine; Carnitine; Choline; Female; Gastro

2021
Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure.
    International journal of cardiology, 2021, 09-01, Volume: 338

    Topics: Choline; Gastrointestinal Microbiome; Heart Failure; Humans; Metagenome; Methylamines; RNA, Ribosoma

2021
FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population.
    Frontiers of medicine, 2022, Volume: 16, Issue:2

    Topics: Carnitine; Choline; Chronic Disease; Heart Failure; Humans; Methylamines; Oxygenases; Prospective St

2022
A pilot study investigating circulating trimethylamine N-oxide and its precursors in dogs with degenerative mitral valve disease with or without congestive heart failure.
    Journal of veterinary internal medicine, 2019, Volume: 33, Issue:1

    Topics: Animals; Carnitine; Case-Control Studies; Choline; Cross-Sectional Studies; Dog Diseases; Dogs; Echo

2019
[Use of lipotropic factors in the therapy of chronic cardiac insufficiency].
    L' Arcispedale S. Anna di Ferrara, 1950, Volume: 3, Issue:4

    Topics: Choline; Heart Failure; Humans; Lipotropic Agents

1950
Brain metabolites in autonomic regulatory insular sites in heart failure.
    Journal of the neurological sciences, 2014, Nov-15, Volume: 346, Issue:1-2

    Topics: Adult; Autonomic Nervous System; Cerebral Cortex; Choline; Creatine; Female; Heart Failure; Humans;

2014
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure.
    Journal of internal medicine, 2015, Volume: 277, Issue:6

    Topics: Aged; Betaine; Biomarkers; Choline; Chronic Disease; Female; Heart Failure; Humans; Intestinal Mucos

2015
Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.
    Circulation. Heart failure, 2016, Volume: 9, Issue:1

    Topics: Animals; Bacteria; Cardiomegaly; Choline; Diet; Disease Models, Animal; Disease Progression; Fibrosi

2016
Prognostic implications of elevated whole blood choline levels in acute coronary syndromes.
    The American journal of cardiology, 2003, May-01, Volume: 91, Issue:9

    Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Arrhythmias, Cardiac; Biomarkers; Choline; Female;

2003
The relation of the choline cycle to cardiac decompensation; acetylcholine metabolism in the dog heart-lung preparation.
    American heart journal, 1953, Volume: 45, Issue:1

    Topics: Acetylcholine; Animals; Choline; Dogs; Heart; Heart Failure; Humans

1953
The inhibition by choline theophyllinate of water retention induced by pitressin.
    International record of medicine and general practice clinics, 1954, Volume: 167, Issue:5

    Topics: Arginine Vasopressin; Choline; Heart Failure; Theophylline; Vasopressins

1954
Choline theophyllinate, a new xanthine drug for the effective oral treatment of congestive heart failure; a preliminary report.
    International record of medicine and general practice clinics, 1954, Volume: 167, Issue:5

    Topics: Choline; Heart Failure; Humans; Theophylline; Treatment Outcome; Xanthine; Xanthines

1954
Treatment of congestive heart failure and anginal syndrome with choline theophyllinate.
    Journal of the American Medical Association, 1955, Jan-15, Volume: 157, Issue:3

    Topics: Angina Pectoris; Choline; Heart Failure; Humans; Theophylline

1955
Management of chronic congestive failure and angina pectoris in geriatric patients with choline theophyllinate.
    Virginia medical monthly, 1957, Volume: 84, Issue:9

    Topics: Aged; Angina Pectoris; Choline; Disease Management; Heart Failure; Humans; Lung Diseases; Theophylli

1957
[Clinical observations on the therapeutic use of choline theophyllinate].
    Gazzetta medica italiana, 1959, Volume: 118

    Topics: Choline; Coronary Disease; Heart Failure; Humans; Hypertension; Theophylline

1959
Effects of heart transplantation on cerebral metabolic abnormalities in patients with congestive heart failure.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2006, Volume: 25, Issue:3

    Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Female; Heart Failure; Heart Transplantation; Humans

2006
Structural atrial remodeling alters the substrate and spatiotemporal organization of atrial fibrillation: a comparison in canine models of structural and electrical atrial remodeling.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Function, Left; Atrial Function, Right; C

2006
Graduated reactions and maximal reactions (T. or N.) in the ventricular myocardium of amphibians in relation to the release of neurohormone factors (acetylcholine)
    Archivio di fisiologia, 1949, Volume: 48, Issue:3-4

    Topics: Choline; Heart Failure

1949
Oral theophylline in chronic heart failure.
    Postgraduate medical journal, 1982, Volume: 58, Issue:678

    Topics: Choline; Heart Failure; Heart Function Tests; Humans; Male; Theophylline; Time Factors

1982
Cerebral metabolic abnormalities in congestive heart failure detected by proton magnetic resonance spectroscopy.
    Journal of the American College of Cardiology, 1999, Volume: 33, Issue:5

    Topics: Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Echocardiography, Doppler; Exercise Test;

1999
Correlation of cerebral metabolites with clinical outcome among patients with severe congestive heart failure.
    Circulation, 2001, Jun-12, Volume: 103, Issue:23

    Topics: Aspartic Acid; Brain; Choline; Cognition Disorders; Creatine; Disease Progression; Heart Failure; Hu

2001